11,549 results match your criteria BJU Int.[Journal]


The Clinical Features and Predictive Factors of Nocturnal Enuresis in Adult Men.

BJU Int 2020 May 31. Epub 2020 May 31.

Bristol Urological Institute, Southmead Hospital, Bristol, UK.

Objectives: To characterize the clinical features and to discover predictive factors of adult male with nocturnal enuresis (NE).

Subjects And Methods: Forty-three eligible adult male subjects (mean age was 57.8 years), were recruited prospectively over a 2-year period. Read More

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http://dx.doi.org/10.1111/bju.15126DOI Listing

How can we motivate patients with bladder cancer to help themselves?

BJU Int 2020 Jun;125(6):751-752

Department of Urology, University of North Carolina, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1111/bju.15090DOI Listing

Optimal medical therapy for male urinary symptoms.

Authors:
Blayne Welk

BJU Int 2020 Jun;125(6):E1-E2

Department of Surgery and Epidemiology and Biostatistics, Western University, London, ON, Canada.

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http://dx.doi.org/10.1111/bju.15067DOI Listing

Low-dose-rate brachytherapy for prostate cancer stands the test of time - the Swiss experience.

BJU Int 2020 Jun;125(6):750-751

St Luke's Cancer Centre, Royal Surrey Hospital, Guildford, Surrey, UK.

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http://dx.doi.org/10.1111/bju.15070DOI Listing

Covid-19 and urology.

Authors:
Prokar Dasgupta

BJU Int 2020 06;125(6):749

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http://dx.doi.org/10.1111/bju.15104DOI Listing

A reflection on an adapted approach from face-to-face to telephone consultations in our Urology outpatient department during the COVID-19 pandemic - a pathway for change to future practice?

BJU Int 2020 May 29. Epub 2020 May 29.

Department of Urology, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom of Great Britain and Northern Ireland.

The sudden and unanticipated COVID-19 viral pandemic of 2020 and its profound impact on the NHS prompted an almost overnight change in the services we are able to offer our patients to fulfil clinical demands. From March 2020 we have changed outpatient appointments from face-to-face to telephone led consultations. We have performed an early review of this service to ensure its sustainability during the unknown duration of this current crisis and to establish its potential utility when normal services resume in the future. Read More

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http://dx.doi.org/10.1111/bju.15119DOI Listing

Understanding Virtual Urology Clinics: A Systematic Review.

BJU Int 2020 May 28. Epub 2020 May 28.

Division of Surgery, Imperial Prostate, Department of Surgery and Cancer, Imperial College London, Charing Cross Campus, W6 8RF, UK.

Objective: To perform a systematic review to identify the clinical, fiscal and environmental evidence on the use of urological telehealth and/or virtual clinic strategies. Our secondary aim was to highlight research gaps in this rapidly evolving field.

Methods: Our PROSPERO registered (CRD42019151946) systematic search of Embase, Medline and Cochrane Review Database was performed for original research articles pertaining to adult urology telehealth or virtual clinic strategies. Read More

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http://dx.doi.org/10.1111/bju.15125DOI Listing

British Association of Urological Surgeons' suprapubic catheter practice guidelines - revised.

BJU Int 2020 May 28. Epub 2020 May 28.

Nottingham City Hospital, Hucknall Road, Nottingham, NG5 1PB.

Aims: To report the updated and revised British Association of Urological Surgeons' (BAUS) guideline on indications, safe insertion and subsequent care of suprapubic catheters.

Methods: The existing BAUS guideline on the insertion of suprapubic catheters was reviewed and has been updated in light of both activity and outcome data published since the original guideline was written. A systematic review of all new data from 2010 onwards was carried out. Read More

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http://dx.doi.org/10.1111/bju.15123DOI Listing

Detection of Clinically Significant Cancer in the Anterior Prostate by Transperineal Biopsy.

BJU Int 2020 May 28. Epub 2020 May 28.

Ballarat Urology, Ballarat Health Services, Department of Surgery.

Objectives: The objective was to determine the incidence of clinically significant prostate cancer detected exclusively in the anterior prostate using transperineal prostate biopsy.

Patients And Methods: Histopathology results of all patients who underwent transperineal prostate biopsy between February 2016 and March 2018 at a single institution were assessed for distribution of cancer within the prostate. Patients with cancer found exclusively in the anterior prostate were then compared to those with any cancer found in the posterior or lateral prostate with International Society of Urological Pathology (ISUP) grade group 2-5 cancers being considered clinically significant. Read More

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http://dx.doi.org/10.1111/bju.15124DOI Listing

Transperineal free-hand mpMRI fusion targeted biopsies under local anesthesia for Prostate Cancer Diagnosis: a multicenter prospective study of 1,014 cases.

BJU Int 2020 May 26. Epub 2020 May 26.

Department of Urology, San Giovanni Battista Hospital, Città della Salute e della Scienza and University of Turin, Turin, Italy.

Background: No large multicentre prospective studies ever addressed the outcomes of mpMRI targeted fusion transperineal biopsy (TPFBx) under local anesthesia (LA). The debate upon best biopsy modality is still open.

Patients And Methods: We prospectively screened for inclusion 1,327 men with a positive mpMRI undergoing TPFBx (targeted cores and systematic cores) under LA, at two tertiary referral institutions, from Sep2016 to May2019. Read More

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http://dx.doi.org/10.1111/bju.15121DOI Listing

Development and validation of explainable AI-based decision-supporting tool for prostate biopsy.

BJU Int 2020 May 26. Epub 2020 May 26.

Department of Urology, Seoul Metropolitan Government - Seoul National University Boramae Medical Center, Seoul, South Korea.

Objectives: To develop and validate a risk calculator for prostate cancer (PC) and clinically significant PC (csPC) using explainable artificial intelligence (XAI).

Materials And Methods: We used data of 3791 patients to develop and validate the risk calculator. We initially divided the data into development and validation sets. Read More

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http://dx.doi.org/10.1111/bju.15122DOI Listing

Our First Month of Delivering the Prostate Cancer Diagnostic Pathway within the Limitations of COVID-19 Using Local Anaesthetic Transperineal Biopsy.

BJU Int 2020 May 26. Epub 2020 May 26.

Department of Urology, Guy's at St Thomas' Hospitals, London, UK.

The COVID-19 pandemic is impacting all urological cancer services. On March 19 the British Association of Urological Surgeons (BAUS) provided pragmatic guidance for prostate cancer diagnostic services (Table 1).(1). Read More

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http://dx.doi.org/10.1111/bju.15120DOI Listing

Multiparametric MRI-Ultrasound Software Fusion Prostate Biopsy - Initial Results Using A Stereotactic Robotic Assisted Transperineal Prostate Biopsy Platform Comparing Systematic Versus Targeted Biopsy.

BJU Int 2020 May 21. Epub 2020 May 21.

Department of Urology, Singapore General Hospital.

Objectives: To compare the detection rates of prostate cancer between systematic biopsy and targeted biopsy using a stereotactic robot-assisted transperineal prostate platform.

Materials And Methods: We identified consecutive men with suspicious lesion(s) on multi-parametric magnetic resonance imaging (mpMRI) who underwent both systematic and MRI-transrectal ultrasound (US) fusion targeted biopsy using our proprietary transperineal robot-assisted prostate biopsy platform between January 2015 to January 2019 at our institution for retrospectively analysis. Comparative analysis between systematic and targeted biopsy using McNemar's test and further stratified by prior biopsy status and PI-RADS v2. Read More

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http://dx.doi.org/10.1111/bju.15118DOI Listing
May 2020
3.533 Impact Factor

Chronic Prostatitis/Chronic Pelvic Pain Syndrome patients show Th1 and Th17 self-reactive immune responses specific to prostate and seminal antigens and decreased semen quality.

BJU Int 2020 May 21. Epub 2020 May 21.

Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.

Objectives: To assess the presence of self-reactive immune responses to seminal and prostate antigens (PAg), biomarkers of inflammation of the male genital tract and semen quality parameters in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).

Subjects And Methods: peripheral blood and semen samples were collected from CP/CPPS patients and age-matched healthy control volunteers. The analysis of lymphoproliferative responses of peripheral blood mononuclear cells (PBMC) to different seminal plasma-derived and purified PAg, serum autoantibodies specific to PAg, leukocyte subpopulations and inflammatory cytokines in semen, sperm apoptosis/necrosis, and semen quality parameters were performed. Read More

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http://dx.doi.org/10.1111/bju.15117DOI Listing

Martini-Klinik experience on prostate cancer surgery during the early phase of COVID-19.

BJU Int 2020 May 18. Epub 2020 May 18.

Martini-Klinik Prostate Cancer Center Hamburg, Hamburg, Germany.

In order to restrain an uncontrolled spread of the 2019 Coronavirus-Disease (COVID-19) and to provide sufficient intensive-care unit (ICU) capacity, medical specializations needed to develop new routines and risk-strategy protocols. Those restrictions have also impacted the urologic community. Several medical organisations developed specific information-hubs, blogs and resource centers on how to tackle the COVID-19 situation (1-3). Read More

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http://dx.doi.org/10.1111/bju.15115DOI Listing

Delivering urgent urological surgery during the COVID-19 pandemic in the United Kingdom: Outcomes from our initial 52 patients.

BJU Int 2020 May 14. Epub 2020 May 14.

Urology Department, Royal Hampshire County Hospital, Romsey Rd, Winchester, SO22 5DG, United Kingdom.

Since first reported in December 2019, the novel RNA betacoronavirus disease (COVID-19) has spread rapidly across the world with, as of the 3rd May 2020, 3.3 million confirmed cases with more than 230,000 deaths worldwide and more than 200 countries affected. The most common symptoms reported include dry cough, fever and fatigue with ground-glass opacification bilaterally in the lungs on imaging and lymphopenia on haematological analysis. Read More

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http://dx.doi.org/10.1111/bju.15110DOI Listing

The impact of the COVID-19 pandemic on the utilization of emergency urological services.

BJU Int 2020 May 14. Epub 2020 May 14.

Department of Urology, Centro Hospitalar Universitário do Porto, Portugal.

Objectives: To compare the number of patients attending the Urology ED of Centro Hospitalar Universitário do Porto (CHUP), as well as their demographic characteristics, the reasons for admission, the clinical severity under the Manchester triage system (MTS), and the need for emergency surgery or hospitalization, during the pandemic and the equivalent period in 2019.

Patients And Methods: Data were collected from patients attending the Urology emergency ward of CHUP during three weeks - from March 11th 2020 to April 1st 2020 - and from the same period the previous year (from March 11th to April 1st 2019).

Results: During the pandemic, 46. Read More

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http://dx.doi.org/10.1111/bju.15109DOI Listing

Robot-assisted intracorporeal orthotopic bladder substitution after radical cystectomy: perioperative morbidity and oncological outcomes - a single institution experience.

BJU Int 2020 May 13. Epub 2020 May 13.

Department of Molecular Medicine and Surgery, Section of Urology, Karolinska Institutet, Stockholm, Sweden.

Objective: To report a single institution experience with totally intracorporeal neobladder urinary diversion after robot-assisted laparoscopic radical cystectomy (RARC).

Patients And Methods: A total of 158 patients underwent totally intracorporeal neobladder urinary diversion after RARC between 2003 - 2016. Patient demographics, intraoperative- and pathologic data, 30-d and 90-d perioperative mortality and complications were recorded. Read More

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http://dx.doi.org/10.1111/bju.15112DOI Listing

Transvesical robot-assisted radical prostatectomy: initial experience and surgical outcomes.

BJU Int 2020 May 13. Epub 2020 May 13.

Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, China.

Objectives: To describe in detail the techniques for transvesical robot-assisted radical prostatectomy (RARP) using the da Vinci Si/Xi system (Intuitive Surgical, Sunnyvale, CA, USA) and to evaluate functional and oncological outcomes in 35 patients with prostate cancer.

Patients And Methods: Thirty-five patients with localized prostate cancer were enrolled for transvesical RARP. The patients' preoperative data (mean ± sd age 63. Read More

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http://dx.doi.org/10.1111/bju.15111DOI Listing

Digital frozen section of the prostate surface during radical prostatectomy: a novel approach to evaluate surgical margins.

BJU Int 2020 May 13. Epub 2020 May 13.

Department of Pathology, Ospedale Policlinico e Nuovo Ospedale Civile S.Agostino Estense Modena, University of Modena and Reggio Emilia, Modena, Italy.

Intra-operative tailoring of surgical dissection during radical prostatectomy (RP) can be performed with the help of either 3D-augmented reality or frozen section analysis [1]. The latter with the purpose of maximizing nerve-sparing (NS) RP has evolved into the NeuroSAFE, a dissection technique of the prostatic surface limited to the neurovascular(NV)-structure-adjacent-prostatic-tissue aiming to detect cancer persisting at the NV-area [2]. Read More

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http://dx.doi.org/10.1111/bju.15108DOI Listing

Avoiding Deep Pelvic Complications Using "Five-Step" Technique for High Submuscular Placement of Inflatable Penile Prosthesis Reservoirs.

BJU Int 2020 May 13. Epub 2020 May 13.

Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX.

Objectives: To compare our extended experience with high submuscular (HSM) reservoir placement to traditional space of Retzius (SOR) placement and to present our current, refined "Five-Step" technique (FST) for HSM placement.

Materials And Methods: Data was retrospectively collected on patients undergoing inflatable penile prosthesis (IPP) placement between January 2009 and June 2019. Reoperative cases were excluded. Read More

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http://dx.doi.org/10.1111/bju.15106DOI Listing

Challenges, applications and future directions of precision medicine in prostate cancer - the role of organoids and patient-derived xenografts.

BJU Int 2020 May 8. Epub 2020 May 8.

Department of Urology, Princess Alexandra Hospital, Brisbane, Qld, Australia.

Objective: To provide a clinically relevant outline of various current precision medicine principles and available evidence on the application and potential for a precision medicine approach in prostate cancer.

Methods: Narrative review of the current literature in the field.

Conclusion: Precision medicine is the concept of individualising patient management based on specific tumour characteristics and biology, rather than traditional histological subtypes. Read More

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http://dx.doi.org/10.1111/bju.15103DOI Listing

Society of Robotic Surgery Review: Recommendations Regarding the Risk of COVID-19 Transmission During Minimally Invasive Surgery.

BJU Int 2020 May 8. Epub 2020 May 8.

Global Robotics Institute, Florida Hospital-Celebration Health Celebration, Orlando, FL.

The COVID-19 pandemic has created uncertainty regarding the safety and appropriate utilization of minimally invasive surgery (MIS) during this current outbreak. Surgical governing bodies such as Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) and the Royal Colleges of Surgery of Great Britain and Ireland have made statements regarding the possibility of COVID-19 release into CO2 insufflant during MIS. The basis for this concern is prior evidence in the literature of other viral pathogen release during laparoscopic surgery. Read More

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http://dx.doi.org/10.1111/bju.15105DOI Listing

Prostate Health Index and multiparametric magnetic resonance imaging to predict prostate cancer grade reclassification in active surveillance.

BJU Int 2020 May 4. Epub 2020 May 4.

Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Objective: To identify the value of combining the Prostate Health Index (PHI) and multiparametric magnetic resonance imaging (mpMRI), tools which have previously been shown to be independently predictive of prostate cancer (PCa) grade reclassification (GR; Gleason score >6), for the purpose of predicting GR at the next surveillance biopsy to reduce unnecessary prostate biopsies for men in PCa active surveillance (AS).

Patients And Methods: Between 2014 and 2019, we retrospectively identified 253 consecutive men in the Johns Hopkins AS programme who had mpMRI and PHI followed by a systematic ± targeted biopsy. PHI and PHI density (PHID) were evaluated across Prostate Imaging-Reporting and Data System version 2. Read More

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http://dx.doi.org/10.1111/bju.15101DOI Listing

Comparing confirmatory biopsy outcomes between MRI-targeted biopsy and standard systematic biopsy among men being enrolled in prostate cancer active surveillance.

BJU Int 2020 May 1. Epub 2020 May 1.

Department of Urology, The University of Texas, M.D. Anderson Cancer Center, Houston, TX, USA.

Objectives: To evaluate the ability of MRI-targeted biopsy combined with systematic biopsy (MRI-biopsy) to reduce negative biopsies and detect clinically significant prostate cancer compared to systematic biopsy (SB) alone in the confirmatory biopsy setting using matched cohorts.

Patients And Methods: Patients were identified from an active surveillance (AS) database who had a previously positive transrectal ultrasound (TRUS) guided SB followed by a confirmatory biopsy at a single institution between 2006-2019. Patients were divided into two cohorts based on confirmatory biopsy technique, either a SB alone or MRI-biopsy (which included MRI-targeted and systematic biopsies). Read More

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http://dx.doi.org/10.1111/bju.15100DOI Listing

Prostate cancer and kidney transplantation - exclusion or co-existence?

BJU Int 2020 May;125(5):628-629

Division of Urological Surgery and Center for Surgery and Public Health, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1111/bju.15078DOI Listing

Corrigendum.

Authors:

BJU Int 2020 May 28;125(5):747. Epub 2020 Feb 28.

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http://dx.doi.org/10.1111/bju.14984DOI Listing

Guidelines on urinary incontinence: it is time to join forces!

Authors:
Thomas M Kessler

BJU Int 2020 May;125(5):625-626

Department of Neuro-Urology, Balgrist University Hospital, University of Zürich, Zürich, Switzerland.

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http://dx.doi.org/10.1111/bju.15075DOI Listing

The provision of comfort: addressing barriers to sleep in prostate cancer.

Authors:
Junaid Nabi

BJU Int 2020 May;125(5):627-628

Department of Surgery, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1111/bju.15053DOI Listing

A randomised Phase II trial of carboplatin and gemcitabine ± vandetanib in first-line treatment of patients with advanced urothelial cell cancer not suitable to receive cisplatin.

BJU Int 2020 Apr 25. Epub 2020 Apr 25.

Southampton Clinical Trials Unit, University of Southampton, Southampton, UK.

Objectives: To assess the efficacy and tolerability of the dual epidermal growth factor receptor/vascular endothelial growth factor receptor inhibitor, vandetanib, in combination with carboplatin and gemcitabine in the first-line treatment of patients with advanced transitional cell carcinoma urothelial cancer (UC) who were unsuitable for cisplatin.

Patients And Methods: From 2011 to 2014, 82 patients were randomised from 16 hospitals across the UK into the TOUCAN double-blind, placebo-controlled randomised Phase II trial, receiving six 21-day cycles of intravenous carboplatin (target area under the concentration versus time curve 4.5, day 1) and gemcitabine (1000 mg/m days 1 and 8) combined with either oral vandetanib 100 mg or placebo (once daily). Read More

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http://dx.doi.org/10.1111/bju.15096DOI Listing

Primary Urethral Cancer - Treatment Patterns and Associated Outcomes.

BJU Int 2020 Apr 26. Epub 2020 Apr 26.

Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, United States.

Objectives: To evaluate treatment patterns and associated outcomes of patients with urethral cancer.

Patients And Methods: After obtaining IRB approval we identified 165 patients treated for primary urethral cancer between 1956-2017. Treatment included monotherapy (surgery or radiation), dual-therapy (surgery+radiation, surgery+chemotherapy, or chemotherapy+radiation) or triple-therapy (surgery+radiation+chemotherapy). Read More

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http://dx.doi.org/10.1111/bju.15095DOI Listing

Long-term Follow-up After Radiotherapy for Prostate Cancer with and without Rectal Hydrogel Spacer: A Pooled Prospective Evaluation of Bowel Associated Quality of Life.

BJU Int 2020 Apr 25. Epub 2020 Apr 25.

RWTH Aachen University, Department of Radiotherapy, Aachen, Germany.

Purpose: Hydrogel spacers are a tool to improve dosimetry and overall quality of life in men receiving radiotherapy for prostate cancer. This study is a pooled analysis of a prospective cohort with long-term quality of life (QOL) follow-up data with or without hydrogel spacers to minimize the dose to adjacent organs at risk.

Methods And Materials: QOL was examined using the Expanded Prostate Cancer Index Composite (EPIC) and mean changes from baseline to EPIC domains were evaluated. Read More

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http://dx.doi.org/10.1111/bju.15097DOI Listing

A modified sequential vascular control strategy in robot-assisted level III-IV inferior vena cava thrombectomy: initial series mimicking the open 'milking' technique principle.

BJU Int 2020 Apr 24. Epub 2020 Apr 24.

Department of Urology/State Key Laboratory of Kidney Diseases, The First Medical Center of Chinese PLA General Hospital/Medical School of Chinese PLA, Beijing, China.

Objective: To introduce a modified sequential vascular control strategy, mimicking the open 'milking' technique principle, for the early release of the first porta hepatis (FPH) and to stop cardiopulmonary bypass (CPB) in level III-IV robot-assisted inferior vena cava (IVC) thrombectomy (RA-IVCTE).

Patients And Methods: From November 2014 to June 2019, 27 patients with a level III-IV IVC tumour thrombus (IVCTT) underwent RA-IVCTE in our department. The modified sequential control strategy was used in 12 cases. Read More

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http://dx.doi.org/10.1111/bju.15094DOI Listing
April 2020
3.533 Impact Factor

International Consultation on Incontinence Questionnaire-Satisfaction: psychometric testing of a new patient-reported outcome measure for the evaluation of satisfaction after urological surgery.

BJU Int 2020 Apr 22. Epub 2020 Apr 22.

Bristol Urological Institute, Southmead Hospital, Bristol, UK.

Objectives: To evaluate the psychometric properties of a new patient-reported outcome measure (PROM), the International Consultation on Incontinence Questionnaire-Satisfaction (ICIQ-S), to assess satisfaction after urological surgery.

Subjects/patients And Methods: Following item development, the developmental ICIQ-S (dICIQ-S) was used within in a randomised control trial comparing two types of surgery for male prostatic obstruction at 1.5, 3, and 12 months after surgery. Read More

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http://dx.doi.org/10.1111/bju.15091DOI Listing

Pelvic exenteration surgery in patients with locally advanced castration-naïve and castration-resistant, symptomatic prostate cancer.

BJU Int 2020 Apr 22. Epub 2020 Apr 22.

Department of Urology, Uro-Oncology, Robot-Assisted and Specialized Urological Surgery, University Hospital Cologne, Cologne, Germany.

Objectives: To evaluate retrospectively the surgical, symptomatic and oncological outcomes of pelvic exenteration surgery (PES) in men with significant intrapelvic complications of locally advanced castration-sensitive (CSPC) and castration-resistant prostate cancer (CRPC).

Patients And Methods: A total of 103 patients with locally advanced progressive and symptomatic CSPC or CRPC underwent PES (radical cystoprostatectomy, n = 71 [68.9%]; radical prostatectomy with continent vesicostomy, n = 9 [8. Read More

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http://dx.doi.org/10.1111/bju.15088DOI Listing

Targeted and systematic cognitive freehand-guided transperineal biopsy: is there still a role for systematic biopsy?

BJU Int 2020 Apr 22. Epub 2020 Apr 22.

Department of Urology, Guy's and Saint Thomas' NHS Foundation Trust, London, UK.

Objectives: To assess whether targeted cognitive freehand-assisted transperineal biopsies using a Precisionpoint device still require additional systematic biopsies to avoid missing clinically significant prostate cancer, and to investigate the benefit of a quadrant-only biopsy approach to analyse whether a quadrant or extended target of the quadrant containing the target only would have been equivalent to systematic biopsy.

Patients And Methods: Patients underwent combined systematic mapping and targeted transperineal prostate biopsies at a single institution. Biopsies were performed using the Precisionpoint device (Perineologic, Cumberland, MD, USA) under either local anaesthetic (58%, 163/282), i. Read More

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http://dx.doi.org/10.1111/bju.15092DOI Listing

Near-infrared fluorescence imaging for intraoperative margin assessment during robot-assisted partial nephrectomy.

BJU Int 2020 Apr 22. Epub 2020 Apr 22.

OhioHealth Robotic Urologic and Cancer Surgery, OhioHealth Dublin Methodist Hospital, Dublin, OH, USA.

Objectives: To demonstrate how using a standardised dosing strategy of indocyanine green (ICG) dye with near-infrared fluorescence (NIRF) imaging can be used to differentiate renal tumours from normal renal parenchyma during robot-assisted partial nephrectomy (RAPN).

Patients And Methods: We reviewed a prospectively collected database of 361 consecutive RAPNs using NIRF between June 2011 and March 2018, and determined the rate at which differential fluorescence was achieved. Tumour and kidney fluorescence or afluorescence were recorded intraoperatively and compared to histological results on final pathology. Read More

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http://dx.doi.org/10.1111/bju.15089DOI Listing

Predicting intra-operative and postoperative consequential events using machine-learning techniques in patients undergoing robot-assisted partial nephrectomy: a Vattikuti Collective Quality Initiative database study.

BJU Int 2020 Apr 21. Epub 2020 Apr 21.

Vattikuti Urology Institute, Henry Ford Hospital, Detroit, MI, USA.

Objective: To predict intra-operative (IOEs) and postoperative events (POEs) consequential to the derailment of the ideal clinical course of patient recovery.

Materials And Methods: The Vattikuti Collective Quality Initiative is a multi-institutional dataset of patients who underwent robot-assisted partial nephectomy for kidney tumours. Machine-learning (ML) models were constructed to predict IOEs and POEs using logistic regression, random forest and neural networks. Read More

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http://dx.doi.org/10.1111/bju.15087DOI Listing

Detection of clinically significant prostate cancer in biopsy-naïve men: direct comparison of systematic biopsy, multiparametric MRI- and contrast-ultrasound-dispersion imaging-targeted biopsy.

BJU Int 2020 Apr 21. Epub 2020 Apr 21.

Department of Urology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.

Objectives: To compare and evaluate a multiparametric magnetic resonance imaging (mpMRI)-targeted biopsy (TBx) strategy, contrast-ultrasound-dispersion imaging (CUDI)-TBx strategy and systematic biopsy (SBx) strategy for the detection of clinically significant prostate cancer (csPCa) in biopsy-naïve men.

Patients And Methods: A prospective, single-centre paired diagnostic study included 150 biopsy-naïve men, from November 2015 to November 2018. All men underwent pre-biopsy mpMRI and CUDI followed by a 12-core SBx taken by an operator blinded from the imaging results. Read More

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http://dx.doi.org/10.1111/bju.15093DOI Listing

Comprehensive analysis of serum chromogranin A and neuron-specific enolase levels in localized and castration-resistant prostate cancer.

BJU Int 2020 Apr 20. Epub 2020 Apr 20.

Department of Urology, Medical University of Vienna, Vienna, Austria.

Objectives: To assess chromogranin A (CGA) and neuron-specific enolase (NSE) levels and changes in these at different stages of prostatic adenocarcinoma (PCA).

Methods: Overall, 1095 serum samples from 395 patients, divided into three treatment groups, were analysed; the radical prostatectomy (RP) cohort (n = 157) included patients with clinically localized PCA, while the docetaxel (DOC) and the abiraterone (ABI)/enzalutamide (ENZA) cohorts included 95 and 143 patients, respectively, with metastatic castration-resistant prostate cancer. CGA, NSE and total PSA levels were measured using the KRYPTOR method. Read More

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http://dx.doi.org/10.1111/bju.15086DOI Listing

The genetic landscapes of urological cancers and their clinical implications in the era of high-throughput genome analysis.

BJU Int 2020 Apr 19. Epub 2020 Apr 19.

Department of Urology, Guy's and St Thomas' NHS Foundation Trust, London, UK.

Objective: With the advent of high-throughput genome analysis, we are increasingly able to sequence and hence understand the pathogenic processes underlying individual cancers. Recently, consortiums such as The Cancer Genome Atlas (TCGA) have performed large-scale projects to this end, providing significant amounts of information regarding the genetic landscapes of several cancers.

Patients And Methods: We performed a narrative review of studies from the TCGA and other major studies. Read More

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http://dx.doi.org/10.1111/bju.15084DOI Listing

A comparative propensity score-matched analysis of perioperative outcomes of intracorporeal vs extracorporeal urinary diversion after robot-assisted radical cystectomy: results from the International Robotic Cystectomy Consortium.

BJU Int 2020 Apr 19. Epub 2020 Apr 19.

Roswell Park Cancer Institute, Buffalo, NY, USA.

Objective: To compare the perioperative outcomes of intracorporeal (ICUD) vs extracorporeal urinary diversion (ECUD) after robot-assisted radical cystectomy (RARC).

Patients And Methods: We retrospectively reviewed the prospectively maintained International Robotic Cystectomy Consortium (IRCC) database. A total of 972 patients from 28 institutions who underwent RARC were included. Read More

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http://dx.doi.org/10.1111/bju.15083DOI Listing

Management of large renal stones with super-mini percutaneous nephrolithotomy: an international multicentre comparative study.

BJU Int 2020 Apr 11. Epub 2020 Apr 11.

Department of Urology, Guangdong Key Laboratory of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Objectives: To comparatively evaluate the clinical outcomes of super-mini percutaneous nephrolithotomy (SMP) and mini-percutaneous nephrolithotomy (Miniperc) for treating urinary tract calculi of >2 cm.

Patients And Methods: An international multicentre, retrospective cohort study was conducted at 20 tertiary care hospitals across five countries (China, the Philippines, Qatar, UK, and Kuwait) between April 2016 and May 2019. SMP and Miniperc were performed in 3525 patients with renal calculi with diameters of >2 cm. Read More

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http://dx.doi.org/10.1111/bju.15066DOI Listing
April 2020
3.533 Impact Factor

Half the message is just mess: judging the value of urodynamics based on partial or poor-quality results.

BJU Int 2020 Apr 11. Epub 2020 Apr 11.

Department of Neuro-Urology, Balgrist University Hospital, University of Zürich, Zürich, Switzerland.

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http://dx.doi.org/10.1111/bju.15063DOI Listing

Effect of temporal pulse shape on urinary stone phantom retropulsion rate and ablation efficiency using holmium:YAG and super-pulse thulium fibre lasers.

BJU Int 2020 Apr 10. Epub 2020 Apr 10.

GRC n°20, Groupe de Recherche Clinique sur la Lithiase Urinaire, Hôpital Tenon, Sorbonne Université, Paris, France.

Objective: To investigate the effects of laser temporal pulse shaping of the super-pulse thulium fibre laser (SPTFL) and to compare these in controlled in vitro conditions with various holmium: yttrium aluminium garnet (Ho:YAG) pulse delivery modes.

Materials And Methods: The SPTFL (Urolase SP, IRE-Polus, Fryazino, Russia), with an emission wavelength of 1.94 μm, and a Ho:YAG laser (P120H; Lumenis, Yokneam, Israel) with Moses technology were compared. Read More

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http://dx.doi.org/10.1111/bju.15079DOI Listing

Global challenges to urology practice during the COVID-19 pandemic.

BJU Int 2020 06 15;125(6):E5-E6. Epub 2020 May 15.

MRC Centre for Transplantation, King's Health Partners, King's College London, London, UK.

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http://dx.doi.org/10.1111/bju.15082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262148PMC
June 2020
3.533 Impact Factor