158 results match your criteria BBA clinical[Journal]


Time resolved amplified FRET identifies protein kinase B activation state as a marker for poor prognosis in clear cell renal cell carcinoma.

BBA Clin 2017 Dec 13;8:97-102. Epub 2017 Oct 13.

Cell Biophysics Laboratory, Ikerbasque, Basque Foundation for Science, FASTBASE SOLUTIONS Ltd, Research Centre for Experimental Marine Biology and Biotechnology (PiE) & Biofísika Institute (UPV/EHU, CSIC), University of the Basque Country, Spain.

Purpose: Clear cell Renal Cell Carcinomas (ccRCC), the largest group of renal tumours, are resistant to classical therapies. The determination of the functional state of actionable biomarkers for the assessment of these adenocarcinomas is essential. The dysregulation of the oncoprotein, PKB/Akt has been linked with poor prognoses in human cancers. Read More

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http://dx.doi.org/10.1016/j.bbacli.2017.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744020PMC
December 2017
3 Reads

Multiple -glycosidases in human serum as detected with the substrate DNP-α-GalNAc. II. Three α--acetylgalactosaminidase-like activities in the pH 5 to 8 region.

BBA Clin 2017 Dec 22;8:90-96. Epub 2017 Sep 22.

Noordwest Ziekenhuisgroep, Laboratory of Clinical Chemistry, Hematology and Immunology, Alkmaar, The Netherlands.

With the substrate DNP-α-GalNAc (2,4-dinitrophenyl--acetyl-α-d-galactosaminide) three α--acetylgalactosaminidase-like activities could be distinguished in serum, in addition to the classical lysosomal enzyme (Naga, EC 3.2.1. Read More

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http://dx.doi.org/10.1016/j.bbacli.2017.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647467PMC
December 2017
5 Reads

Multiple -glycosidases in human serum as detected with the substrate DNP-α-GalNAc. I. A new assay for lysosomal α--acetylgalactosaminidase.

BBA Clin 2017 Dec 7;8:84-89. Epub 2017 Oct 7.

Noordwest Ziekenhuisgroep, Laboratory of Clinical Chemistry, Hematology and Immunology, Alkmaar, The Netherlands.

This paper presents a new assay to determine the activity of the lysosomal enzyme α--acetylgalactosaminidase (Naga, EC 3.2.1. Read More

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http://dx.doi.org/10.1016/j.bbacli.2017.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645117PMC
December 2017
2 Reads

Iron retention in iron-fortified rice and use of iron-fortified rice to treat women with iron deficiency: A pilot study.

BBA Clin 2017 Dec 8;8:78-83. Epub 2017 Sep 8.

Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, United States.

Objectives: 1. Evaluate the effect of washing and cooking iron-fortified rice on iron retention and bioavailability. 2. Read More

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http://dx.doi.org/10.1016/j.bbacli.2017.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608553PMC
December 2017
17 Reads

Antioxidative activity of high-density lipoprotein (HDL): Mechanistic insights into potential clinical benefit.

BBA Clin 2017 Dec 19;8:66-77. Epub 2017 Aug 19.

National Institute for Health and Medical Research (INSERM), UMR ICAN 1166, University of Pierre and Marie Curie-Paris 6, AP-HP, Groupe hospitalier Pitié-Salpétrière, Paris F-75013, France.

Uptake of low-density lipoprotein (LDL) particles by macrophages represents a key step in the development of atherosclerotic plaques, leading to the foam cell formation. Chemical modification of LDL is however necessary to induce this process. Proatherogenic LDL modifications include aggregation, enzymatic digestion and oxidation. Read More

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http://dx.doi.org/10.1016/j.bbacli.2017.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597817PMC
December 2017
20 Reads

Signatures derived from increase in SHARPIN gene copy number are associated with poor prognosis in patients with breast cancer.

BBA Clin 2017 Dec 24;8:56-65. Epub 2017 Aug 24.

Division of Nephrology, Department of Medicine, McMaster University, St. Joseph's Hospital, Hamilton, Ontario, Canada.

We report three signatures produced from gene copy number increase (GCN-Increase) and their effects on patients with breast cancer (BC). In the Metabric dataset (n = 2059, cBioPortal), GCN-Increase occurs preferentially or mutual exclusively with mutations in , , and . These genomic alterations constitute a signature (SigMut) that significantly correlates with reductions in overall survival (OS) in BC patients (n = 1980; p = 1. Read More

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http://dx.doi.org/10.1016/j.bbacli.2017.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582379PMC
December 2017
1 Read

Spontaneous miscarriage in first trimester pregnancy is associated with altered urinary metabolite profile.

BBA Clin 2017 Dec 19;8:48-55. Epub 2017 Aug 19.

KK Women's and Children's Hospital, 100 Bukit Timah Road, 229899, Singapore.

Threatened miscarriage is the most common gynecological emergency, occurring in about 20% of pregnant women. Approximately one in four of these patients go on to have spontaneous miscarriage and the etiology of miscarriage still remains elusive. In a bid to identify possible biomarkers and novel treatment targets, many studies have been undertaken to elucidate the pathways that lead to a miscarriage. Read More

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http://dx.doi.org/10.1016/j.bbacli.2017.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574812PMC
December 2017
27 Reads

Treatment of mild to moderate carpal tunnel syndrome in patients with diabetic neuropathy using low level laser therapy versus ultrasound controlled comparative study.

BBA Clin 2017 Dec 20;8:43-47. Epub 2017 Jul 20.

Elsahel Teatching Hospital, Egypt.

Aim: The aim of the present study was to investigate and compare between Low Level Laser Therapy (LLLT) and Ultrasound (US) in treatment of Carpal Tunnel Syndrome (CTS) using the advantage of application of treatment directly over the transverse carpal ligament, as well as over the course of the median nerve in the forearm simultaneously.

Design: Fifty patients (25-55 years) with diabetic neuropathy, diagnosed as unilateral carpal tunnel syndrome participated in the study. They were equally divided and randomly assigned into two groups; each group consisted of 25 patients. Read More

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http://dx.doi.org/10.1016/j.bbacli.2017.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567639PMC
December 2017
7 Reads

Alterations in antioxidant system, mitochondrial biogenesis and autophagy in preeclamptic myometrium.

BBA Clin 2017 Dec 3;8:35-42. Epub 2017 Jul 3.

Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of the Russian Federation, 4, Oparina street, Moscow 117997, Russia.

Preeclampsia is a pregnancy complication which causes significant maternal and fetal morbidity and mortality worldwide. Although intensive research has been performed in the last 40 years, the pathology of preeclampsia is still poorly understood. The present work is a comparative study of the myometrium of women with normal pregnancy, and those with late- and early-onset preeclampsia (n = 10 for each group). Read More

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http://dx.doi.org/10.1016/j.bbacli.2017.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512187PMC
December 2017
6 Reads

Novel panel of protein biomarkers to predict response to bortezomib-containing induction regimens in multiple myeloma patients.

BBA Clin 2017 Dec 7;8:28-34. Epub 2017 Jun 7.

Mater Misericordiae University Hospital, Dublin 7, Ireland.

Background: Multiple myeloma (MM) is a complex heterogeneous disease. Various risk stratification models have been recommended including cytogenetic and FISH analysis to identify high-risk patients who may benefit from novel treatments, but such facilities are not widely available. The International Scoring System (ISS) using beta-2-microglobulin and albumin remains a widely used prognostic scoring system in many clinical practices; however it is not useful in predicting response to treatment in MM. Read More

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http://dx.doi.org/10.1016/j.bbacli.2017.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502697PMC
December 2017
26 Reads

Abnormal amyloid β expression and increased oxidative stress in plasma of CKD patients with cognitive dysfunction: A small scale case control study comparison with Alzheimer's disease.

BBA Clin 2017 Dec 23;8:20-27. Epub 2017 Jun 23.

Department of Medical Research, SRM Medical College Hospital, SRM University, Chennai, India.

Background: Cognitive dysfunction has been increasingly recognized in chronic kidney disease (CKD) patients. Senile plaques are important pathophysiological characteristic of cognitive dysfunction. The major component of plaques is the amyloid β (Aβ) peptide released from proteolytic cleavage of amyloid precursor protein (APP). Read More

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http://dx.doi.org/10.1016/j.bbacli.2017.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491400PMC
December 2017
9 Reads

Cumulus cell mitochondrial activity in relation to body mass index in women undergoing assisted reproductive therapy.

BBA Clin 2017 Jun 5;7:141-146. Epub 2017 Apr 5.

Federal State Budget Institution "Research Center for Obstetrics, Gynecology and Perinatology", Ministry of Healthcare of the Russian Federation, 4 Oparina street, Moscow 117997, Russian Federation.

Most studies have considered the negative influence of obesity on fertility in both genders. In the present study, we assessed mitochondrial activity expressed as the mitochondrial potential index (MPI) in cumulus cells from obese women and women with a normal body mass index (BMI) during assisted reproductive therapy. The results revealed a significant reduction of MPI with increased body mass. Read More

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http://dx.doi.org/10.1016/j.bbacli.2017.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481670PMC
June 2017
19 Reads

Accumulated substancies and calorific capacity in adipose tissue: Physical and chemical clinical trial.

BBA Clin 2017 Dec 30;8:14-19. Epub 2017 May 30.

Kazakh University for technology and business, Astana, Kazakhstan.

Aim: To study physical and chemical structures and properties including calorific value of human adipose tissue in different anatomical location in autopsy-assigned clinical trial.

Methods: A pilot physical and chemical descriptive randomized autopsy-assigned trial. Adipose tissue 252 sampled from 36 individuals at autopsy who between 36 and 63 years old died from road accidents. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22146474173000
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http://dx.doi.org/10.1016/j.bbacli.2017.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466547PMC
December 2017
11 Reads

Rapid diagnosis and intraoperative margin assessment of human lung cancer with fluorescence lifetime imaging microscopy.

BBA Clin 2017 Dec 27;8:7-13. Epub 2017 Apr 27.

Department of Optical Science and Engineering, Shanghai Engineering Research Center of Ultra-Precision Optical Manufacturing, Key Laboratory of Micro and Nano Photonic Structures (Ministry of Education), Green Photoelectron Platform, Fudan University, 220 Handan Road, Shanghai 200433, China.

A method of rapidly differentiating lung tumor from healthy tissue is extraordinarily needed for both the diagnosis and the intraoperative margin assessment. We assessed the ability of fluorescence lifetime imaging microscopy (FLIM) for differentiating human lung cancer and normal tissues with the autofluorescence, and also elucidated the mechanism in tissue studies and cell studies. A 15-patient testing group was used to compare FLIM results with traditional histopathology diagnosis. Read More

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http://dx.doi.org/10.1016/j.bbacli.2017.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447569PMC
December 2017
87 Reads

Body mass index is associated with region-dependent metabolic reprogramming of adipose tissue.

BBA Clin 2017 Dec 11;8:1-6. Epub 2017 May 11.

Multidisciplinary Unit for Biomedical Research, UMIB-FCT, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Portugal.

Adipose tissue (AT) is involved in dysmetabolism pathogenesis. Regional fat distribution and functioning may contribute to obesity-related metabolic disorders and adverse health outcomes. Specific fat depots are suggested to possess unique biological properties, but specific metabolic profiles of subcutaneous (SAT) and visceral adipose tissue (VAT) remain unknown. Read More

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http://dx.doi.org/10.1016/j.bbacli.2017.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440253PMC
December 2017
23 Reads

Pathogenicity in POLG syndromes: DNA polymerase gamma pathogenicity prediction server and database.

BBA Clin 2017 Jun 18;7:147-156. Epub 2017 Apr 18.

Institute of Biosciences and Medical Technology, University of Tampere, Tampere, Finland.

DNA polymerase gamma (POLG) is the replicative polymerase responsible for maintaining mitochondrial DNA (mtDNA). Disorders related to its functionality are a major cause of mitochondrial disease. The clinical spectrum of POLG syndromes includes Alpers-Huttenlocher syndrome (AHS), childhood myocerebrohepatopathy spectrum (MCHS), myoclonic epilepsy myopathy sensory ataxia (MEMSA), the ataxia neuropathy spectrum (ANS) and progressive external ophthalmoplegia (PEO). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22146474173000
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http://dx.doi.org/10.1016/j.bbacli.2017.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413197PMC
June 2017
8 Reads

Applying a systems approach to thyroid physiology: Looking at the whole with a mitochondrial perspective instead of judging single TSH values or why we should know more about mitochondria to understand metabolism.

BBA Clin 2017 Jun 4;7:127-140. Epub 2017 Apr 4.

WOMED, Karl-Kapferer-Strasse 5, AT-6020 Innsbruck, Austria.

Classical thinking in endocrine physiology squeezes our diagnostic handling into a simple negative feedback mechanism with a controller and a controlled variable. In the case of the thyroid this is reduced to TSH and fT3 and fT4, respectively. The setting of this tight notion has no free space for any additions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22146474163007
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http://dx.doi.org/10.1016/j.bbacli.2017.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390562PMC
June 2017
7 Reads

Detection of copy number alterations in cell-free tumor DNA from plasma.

BBA Clin 2017 Jun 4;7:120-126. Epub 2017 Apr 4.

Center for Genomic Medicine, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark.

Background: Somatic copy number alterations (SCNAs) occurring in tumors can provide information about tumor classification, patient's outcome or treatment targets. Liquid biopsies, incl. plasma samples containing circulating cell-free tumor DNA (ccfDNA) can be used to assess SCNAs for clinical purposes, however specify and reliability of methods have to be tested. Read More

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http://dx.doi.org/10.1016/j.bbacli.2017.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390666PMC

A post-publication analysis of the idealized upper reference value of 2.5 mIU/L for TSH: Time to support the thyroid axis with magnesium and iron especially in the setting of reproduction medicine.

BBA Clin 2017 Jun 19;7:115-119. Epub 2017 Mar 19.

WOMED, Karl-Kapferer-Strasse 5, 6020 Innsbruck, Austria.

Laboratory medicine approaches the evaluation of thyroid function mostly through the single determination of the blood level of thyroid stimulating hormone (TSH). Some authors have suggested an upper reference value for TSH of 2.5 mIU/L. Read More

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http://dx.doi.org/10.1016/j.bbacli.2017.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385584PMC

The plasma lipidome in acute myeloid leukemia at diagnosis in relation to clinical disease features.

BBA Clin 2017 Jun 8;7:105-114. Epub 2017 Mar 8.

Hepatology Research Group, Department of Clinical Research, University of Bern, Switzerland.

Background: Early studies established that certain lipids were lower in acute myeloid leukemia (AML) cells than normal leukocytes. Because lipids are now known to play an important role in cell signaling and regulation of homeostasis, and are often perturbed in malignancies, we undertook a comprehensive lipidomic survey of plasma from AML patients at time of diagnosis and also healthy blood donors.

Methods: Plasma lipid profiles were measured using three mass spectrometry platforms in 20 AML patients and 20 healthy blood donors. Read More

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http://dx.doi.org/10.1016/j.bbacli.2017.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357680PMC
June 2017
10 Reads

Proteomic analysis of bronchoalveolar lavage fluid (BALF) from lung cancer patients using label-free mass spectrometry.

BBA Clin 2017 Jun 6;7:97-104. Epub 2017 Mar 6.

Department of Biology, Maynooth University, Maynooth, Co. Kildare, Ireland.

Background: Lung cancer is the leading cause of cancer-related mortality in both men and women throughout the world. The need to detect lung cancer at an early, potentially curable stage, is essential and may reduce mortality by 20%. The aim of this study was to identify distinct proteomic profiles in bronchoalveolar fluid (BALF) and plasma that are able to discriminate individuals with benign disease from those with non-small cell lung cancer (NSCLC). Read More

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http://dx.doi.org/10.1016/j.bbacli.2017.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357681PMC
June 2017
1 Read

Enzyme replacement therapy for Farber disease: Proof-of-concept studies in cells and mice.

BBA Clin 2017 Jun 13;7:85-96. Epub 2017 Feb 13.

Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, USA.

A series of studies were carried out in Farber disease (OMIM #228000) cells and mice to evaluate the feasibility of enzyme replacement therapy (ERT) for this disorder. Media from Chinese hamster ovary (CHO) cells overexpressing human recombinant acid ceramidase (rhAC) was used to treat fibroblasts from a Farber disease patient, leading to significantly reduced ceramide. We also found that chondrocytes from Farber disease mice had a markedly abnormal chondrogenic phenotype, and this was corrected by rhAC as well. Read More

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http://dx.doi.org/10.1016/j.bbacli.2017.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338723PMC
June 2017
10 Reads

Regulation of cardiac CACNB2 by microRNA-499: Potential role in atrial fibrillation.

BBA Clin 2017 Jun 9;7:78-84. Epub 2017 Feb 9.

Department of Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

The L-type calcium channel (LTCC) is one of the major ion channels that are known to be associated with the electrical remodeling of atrial fibrillation (AF). In AF, there is significant downregulation of the LTCC, but the underlying mechanism for such downregulation is not clear. We have previously reported that microRNA-499 (miR-499) is significantly upregulated in patients with permanent AF and that the gene that encodes the small-conductance calcium-activated potassium channel 3 (SK3), is a target of miR-499. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22146474163006
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http://dx.doi.org/10.1016/j.bbacli.2017.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318290PMC
June 2017
15 Reads

Understanding breast cancer - The long and winding road.

BBA Clin 2017 Jun 27;7:64-77. Epub 2017 Jan 27.

Department of Biochemistry, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada.

Background: Despite a remarkable increase in the depth of our understanding and management of breast cancer in the past 50 years, the disease is still a major public health problem worldwide and poses significant challenges. The palpability of breast tumors has facilitated diagnosis and documentation since ancient times. The earliest descriptions of breast cancer date back to around 3500 BCE. Read More

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http://dx.doi.org/10.1016/j.bbacli.2017.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300293PMC
June 2017
41 Reads

Plasma protein-bound di-tyrosines as biomarkers of oxidative stress in end stage renal disease patients on maintenance haemodialysis.

BBA Clin 2017 Jun 5;7:55-63. Epub 2017 Jan 5.

Department of Biosciences, Università degli Studi di Milano, via Celoria 26, I-20133 Milan, Italy.

Background: Patients with end-stage renal disease (ESRD) undergoing haemodialysis (HD) experience enhanced oxidative stress and systemic inflammation, which are risk factors for cardiovascular disease, the most common cause of excess morbidity and mortality for these patients. Different pathways producing different types of oxidative stress occur in ESRD. The purpose of our study was to determine the effect of HD on plasma levels of protein-bound dityrosine (di-Tyr), a biomarker of protein oxidation. Read More

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http://dx.doi.org/10.1016/j.bbacli.2016.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5257032PMC
June 2017
70 Reads

Metabolic relationship between diabetes and Alzheimer's Disease affected by Cyclo(His-Pro) plus zinc treatment.

BBA Clin 2017 Jun 2;7:41-54. Epub 2016 Oct 2.

VA Greater Los Angeles Healthcare System, 16111, Plummer Street, North Hills, CA 91343; UCLA School of Medicine, 1O833 Le Conte Avenue, Los Angeles, CA 90095.

Background: Association of Alzheimer's Disease (AD) with Type 2 Diabetes (T2D) has been well established. Cyclo(His-Pro) plus zinc (Cyclo-Z) treatment ameliorated diabetes in rats and similar improvements have been seen in human patients. Treatment of amyloid precursor protein (APP) transgenic mice with Cyclo-Z exhibited memory improvements and significantly reduced Aβ-40 and Aβ-42 protein levels in the brain tissues of the mice. Read More

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http://dx.doi.org/10.1016/j.bbacli.2016.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5219633PMC
June 2017
6 Reads

Hemophagocytic lymphohistiocytosis in adults: An under recognized entity.

BBA Clin 2017 Jun 20;7:36-40. Epub 2016 Dec 20.

Department of Leukemia, UT MD Anderson Cancer Center, United States.

Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of severe immune activation with macrophage and T-cell infiltration resulting in, multi organ damage. HLH may be primary or secondary in etiology. A high index of suspicion is essential for early diagnosis and treatment. Read More

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http://dx.doi.org/10.1016/j.bbacli.2016.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5219626PMC
June 2017
13 Reads

Lysozyme association with circulating RNA, extracellular vesicles, and chronic stress.

BBA Clin 2017 Jun 20;7:23-35. Epub 2016 Dec 20.

Digestive Disorders Unit, Division of Intramural Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.

Background: Stress has demonstrated effects on inflammation though underlying cell-cell communication mechanisms remain unclear. We hypothesize that circulating RNAs and extracellular vesicles (EVs) in patients with chronic stress contain signals with functional roles in cell repair.

Methods: Blood transcriptome from patients with Irritable Bowel Syndrome versus controls were compared to identify signaling pathways and effectors. Read More

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http://dx.doi.org/10.1016/j.bbacli.2016.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5200883PMC
June 2017
39 Reads

Microparticle subpopulations are potential markers of disease progression and vascular dysfunction across a spectrum of connective tissue disease.

BBA Clin 2017 Jun 10;7:16-22. Epub 2016 Nov 10.

Centre for Musculoskeletal Research, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, The University of Manchester, United Kingdom; NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospital NHS Foundation Trust and Manchester Academic Health Science Centre, Manchester, United Kingdom.

Objective: Microparticles (MPs) are membrane-bound vesicles derived from vascular and intravascular cells such as endothelial cells (EMPs) and platelets (PMPs). We investigated EMP and PMP numbers across a spectrum of autoimmune rheumatic diseases (AIRDs) with the aim of comparing the levels of, and relationship between, EMPs and PMPs.

Methods: Patients with Systemic Lupus Erythematosus (SLE) ( = 24), Systemic Sclerosis (SSc) ( = 24), Primary Raynauds Phenomenon (RP) ( = 17) and "other CTD" ( = 15) (Primary Sjogrens Syndrome, UCTD or MCTD) as well as 15 healthy controls were recruited. Read More

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http://dx.doi.org/10.1016/j.bbacli.2016.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5199156PMC
June 2017
2 Reads

Metabolomic analysis identifies differentially produced oral metabolites, including the oncometabolite 2-hydroxyglutarate, in patients with head and neck squamous cell carcinoma.

BBA Clin 2017 Jun 18;7:8-15. Epub 2016 Dec 18.

Center for Medical Mycology, Department of Dermatology, Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH, United States.

Background: Metabolomics represents a promising approach for discovering novel targets and biomarkers in head and neck squamous cell carcinoma (HNSCC). Here we used metabolomics to identify oral metabolites associated with HNSCC.

Methods: Tumor and adjacent normal tissue from surgical resections and presurgical oral washes as well as oral washes were collected from healthy participants. Read More

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http://dx.doi.org/10.1016/j.bbacli.2016.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5199158PMC
June 2017
17 Reads

Signaling mechanisms implicated in cranial sutures pathophysiology: Craniosynostosis.

BBA Clin 2016 Dec 29;6:165-176. Epub 2016 Apr 29.

Department of Biological Chemistry - Cellular and Molecular Biomechanics Unit, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.

Normal extension and skull expansion is a synchronized process that prevails along the osteogenic intersections of the cranial sutures. Cranial sutures operate as bone growth sites allowing swift bone generation at the edges of the bone fronts while they remain patent. Premature fusion of one or more cranial sutures can trigger craniosynostosis, a birth defect characterized by dramatic manifestations in appearance and functional impairment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22146474163002
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http://dx.doi.org/10.1016/j.bbacli.2016.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144105PMC
December 2016
7 Reads

Relationship between level of HbA1C and breast cancer.

BBA Clin 2016 Dec 23;6:45-48. Epub 2016 Apr 23.

Departments of Dietetics and Nutrition, University of Arkansas for Medical Sciences, 4301 W. Markham St., Little Rock, AR 72205, USA; Departments of Pediatrics, University of Arkansas for Medical Sciences, 4301 W. Markham St., Little Rock, AR 72205, USA; Arkansas Children's Hospital Research Institute, 13 Children's Way., Little Rock, AR 72202, USA.

Background: Diabetes and cancer are public health issues worldwide; studies have shown that diabetes is related to increased breast cancer mortality. The purpose of this study was to examine associations between HbA1C and obesity with tumor stage and mortality among breast cancer patients.

Methods: Data for 82 patients with breast cancer (36-89 years of age, diagnosed /treated 1999-2009) were provided by the University of Arkansas for Medical Sciences (UAMS) Data Trust Warehouse. Read More

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http://dx.doi.org/10.1016/j.bbacli.2016.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144103PMC
December 2016
3 Reads

A novel dominant D109A mutation in a family with myofibrillar myopathy affects αB-crystallin structure.

BBA Clin 2017 Jun 11;7:1-7. Epub 2016 Nov 11.

Faculty of Chemistry and Biological and Chemical Research Centre, University of Warsaw, 1 Pasteur St., 02-093 Warsaw, Poland.

Myofibrillar myopathy (MFM) is a group of inherited muscular disorders characterized by myofibrils dissolution and abnormal accumulation of degradation products. So far causative mutations have been identified in nine genes encoding Z-disk proteins, including αB-crystallin (CRYAB), a small heat shock protein (also called HSPB5). Here, we report a case study of a 63-year-old Polish female with a progressive lower limb weakness and muscle biopsy suggesting a myofibrillar myopathy, and extra-muscular multisystemic involvement, including cataract and cardiomiopathy. Read More

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http://dx.doi.org/10.1016/j.bbacli.2016.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124346PMC
June 2017
16 Reads

Lymph node or perineural invasion is associated with low miR-15a, miR-34c and miR-199b levels in head and neck squamous cell carcinoma.

BBA Clin 2016 Dec 5;6:159-164. Epub 2016 Nov 5.

Hemotherapy Center of Ribeirão Preto, Ribeirão Preto Medical School, University of São Paulo, Brazil; Department of Clinical Analyses, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Brazil.

Background: MicroRNAs (miRNAs or miRs) are post-transcriptional regulators of eukaryotic cells and knowledge of differences in miR levels may provide new approaches to diagnosis and therapy.

Methods: The present study measured the levels of nine miRs in head and neck squamous cell carcinomas (HNSCC) and determined whether clinical pathological features are associated with differences in miR levels. SET (I2PP2A) and PTEN protein levels were also measured, since their levels can be regulated by miR-199b and miR-21, respectively. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22146474163005
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http://dx.doi.org/10.1016/j.bbacli.2016.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123084PMC
December 2016
9 Reads

Attention deficit-hyperactivity disorder suffers from mitochondrial dysfunction.

BBA Clin 2016 Dec 18;6:153-158. Epub 2016 Oct 18.

CSIR-Indian Institute of Chemical Biology, Laboratory of Clinical & Experimental Neurosciences, Cell Biology & Physiology Division, 4, Raja S.C. Mullick Road, Kolkata - 700032, India; Inter University Centre for Biomedical Research & Super Specialty Hospital, Mahatma Gandhi University Campus at Thalappady, Rubber Board PO, Kottayam - 686009, Kerala State, India.

Background: Pathophysiology of attention-deficit hyperactivity disorder (ADHD) is not known, and therefore the present study investigated mitochondrial defects, if any in cybrids created from patients and control population.

Methods: To investigate mitochondrial pathology in ADHD, cybrids cell lines were created from ADHD probands and controls by fusing their platelets with ρ-cells prepared from SH-SY5Y neuroblastoma cell line. Cellular respiration, oxidative stress, mitochondrial membrane potential and morphology were evaluated employing oxygraph, mitochondria-specific fluorescence staining and evaluation by FACS, and immunocytochemistry. Read More

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http://dx.doi.org/10.1016/j.bbacli.2016.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121149PMC
December 2016
39 Reads

Ovarian-like differentiation in eutopic and ectopic endometrioses with aberrant FSH receptor, INSL3 and GATA4/6 expression.

BBA Clin 2016 Dec 5;6:143-152. Epub 2016 Nov 5.

Faculté de Médecine Paris Sud, Univ Paris Sud, Université Paris Saclay, Hôpital Bicêtre, Le Kremlin Bicêtre, France.

Endometriosis, the hormone-dependent extrauterine dissemination of endometrial tissue outside the uterus, affects 5-15% of women of reproductive age. Pathogenesis remains poorly understood as well as the estrogen production by endometriotic tissue yielding autocrine growth. Estrogens (E2) are normally produced by the ovaries. Read More

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http://dx.doi.org/10.1016/j.bbacli.2016.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118588PMC
December 2016
6 Reads

Clinical significance of serum omentin-1 levels in patients with pancreatic adenocarcinoma.

BBA Clin 2016 Dec 15;6:138-142. Epub 2016 Oct 15.

Department of Medical Oncology, Institute of Oncology, Istanbul University, Istanbul, Turkey.

Background: Omentin is related with metabolic syndrome and obesity. Pancreatic adenocarcinoma (PA) is a lethal and obesity-linked malignancy. This study was conducted to investigate the serum levels of omentin in patients with PA and the relationship with tumor progression and known prognostic parameters. Read More

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http://dx.doi.org/10.1016/j.bbacli.2016.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079241PMC
December 2016
15 Reads

Metabolic response to glatiramer acetate therapy in multiple sclerosis patients.

BBA Clin 2016 Dec 18;6:131-137. Epub 2016 Oct 18.

Department of Biological and Environmental Sciences and Technologies, University of Salento, via Prov.le Lecce-Monteroni, Lecce, Italy.

Glatiramer acetate (GA; Copaxone) is a random copolymer of glutamic acid, lysine, alanine, and tyrosine used for the treatment of patients with multiple sclerosis (MS). Its mechanism of action has not been already fully elucidated, but it seems that GA has an immune-modulatory effect and neuro-protective properties. Lymphocyte mitochondrial dysfunction underlines the onset of several autoimmune disorders. Read More

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http://dx.doi.org/10.1016/j.bbacli.2016.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079236PMC
December 2016
2 Reads

Controversies and evidence of hepatic resection for hepatocellular carcinoma.

BBA Clin 2016 Dec 11;6:125-130. Epub 2016 Oct 11.

Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.

Symptoms of early hepatocellular carcinoma (HCC) often go unnoticed, so more than half of patients with primary HCC are diagnosed after their disease has already reached an intermediate or advanced stage, or after portal hypertension has appeared. While hepatic resection is widely recognized as a first-line therapy to treat very early or early HCC, its use in treating intermediate or advanced HCC or HCC involving portal hypertension remains controversial. Here we review PubMed-indexed literature covering the use of hepatic resection for such patients. Read More

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http://dx.doi.org/10.1016/j.bbacli.2016.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067978PMC
December 2016
11 Reads

Shining light on the head: Photobiomodulation for brain disorders.

BBA Clin 2016 Dec 1;6:113-124. Epub 2016 Oct 1.

Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.

Photobiomodulation (PBM) describes the use of red or near-infrared light to stimulate, heal, regenerate, and protect tissue that has either been injured, is degenerating, or else is at risk of dying. One of the organ systems of the human body that is most necessary to life, and whose optimum functioning is most worried about by humankind in general, is the brain. The brain suffers from many different disorders that can be classified into three broad groupings: traumatic events (stroke, traumatic brain injury, and global ischemia), degenerative diseases (dementia, Alzheimer's and Parkinson's), and psychiatric disorders (depression, anxiety, post traumatic stress disorder). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22146474163003
Publisher Site
http://dx.doi.org/10.1016/j.bbacli.2016.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066074PMC
December 2016
13 Reads

ST-elevation myocardial infarction risk in the very elderly.

BBA Clin 2016 Dec 4;6:108-12. Epub 2016 Sep 4.

Cardiology Department, State University of Campinas (Unicamp), Campinas, SP, Brazil.

Background: Despite the high incidence and mortality of ST-segment elevation myocardial infarction (STEMI) among the very elderly, risk markers for this condition remain poorly defined. This study was designed to identify independent markers of STEMI among individuals carefully selected for being healthy or manifesting STEMI in < 24 h.

Methods: We enrolled participants aged 80 years or older of whom 50 were STEMI patients and 207 had never manifested cardiovascular diseases. Read More

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http://dx.doi.org/10.1016/j.bbacli.2016.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024138PMC
December 2016
4 Reads

Treatment with recombinant human bone morphogenetic protein 7 leads to a transient induction of neutralizing autoantibodies in a subset of patients.

BBA Clin 2016 Dec 3;6:100-7. Epub 2016 Aug 3.

Institute for Experimental Endocrinology, Charité - Universitätsmedizin Berlin, D-13353 Berlin, Germany.

Background: Recombinant human bone morphogenetic protein 7 (rhBMP7) is applied for treatment of bone fractures, especially tibial non-unions. Its application may induce autoantibodies (aAB) affecting the targeted and endogenous signaling pathways and in turn negatively impact treatment efficacy.

Methods: Novel and sensitive assays for the quantification of BMP7-aAB and BMP2-aAB were established and used to analyze serum samples from healthy controls (n = 100 men, n = 100 women) and patients with long bone fracture (n = 265) treated or not with rhBMP7. Read More

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http://dx.doi.org/10.1016/j.bbacli.2016.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007422PMC
December 2016
5 Reads

The broken "Off" switch in cancer signaling: PP2A as a regulator of tumorigenesis, drug resistance, and immune surveillance.

Authors:
Peter P Ruvolo

BBA Clin 2016 Dec 3;6:87-99. Epub 2016 Aug 3.

Department of Leukemia, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 0425, Houston, TX 77030, United States.

Aberrant activation of signal transduction pathways can transform a normal cell to a malignant one and can impart survival properties that render cancer cells resistant to therapy. A diverse set of cascades have been implicated in various cancers including those mediated by serine/threonine kinases such RAS, PI3K/AKT, and PKC. Signal transduction is a dynamic process involving both "On" and "Off" switches. Read More

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http://dx.doi.org/10.1016/j.bbacli.2016.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986044PMC
December 2016
4 Reads

Induction of differentiation in psoriatic keratinocytes by propylthiouracil and fructose.

BBA Clin 2016 Dec 30;6:82-6. Epub 2016 Jun 30.

Saveetha University, Chennai 602105, Tamil Nadu, India.

Psoriasis is characterized by uncontrolled proliferation and poor differentiation. Sirtuin1 (SIRT1) a class III deacetylase, crucial for differentiation in normal keratinocytes, is reduced in psoriasis. Down regulated SIRT1 levels may contribute to poor differentiation in psoriasis. Read More

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http://dx.doi.org/10.1016/j.bbacli.2016.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941040PMC
December 2016
5 Reads

Lipid profile of platelets and platelet-derived microparticles in ovarian cancer.

BBA Clin 2016 Dec 30;6:76-81. Epub 2016 Jun 30.

Department of Benign Hematology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

Background: Ovarian cancer patients have a high risk of developing venous thrombosis. The membrane lipid bilayer of platelets and platelet-derived microparticles (PMP) provides a platform for assembly of coagulation proteins and generation of blood clots.

Methods: We compared the lipid composition of platelets and PMPs in patients with ovarian cancer to those in healthy subjects. Read More

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http://dx.doi.org/10.1016/j.bbacli.2016.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941562PMC
December 2016
17 Reads

Heart failure in chemotherapy-related cardiomyopathy: Can exercise make a difference?

BBA Clin 2016 Dec 15;6:69-75. Epub 2016 Jun 15.

Memorial Cardiac and Vascular Institute, Hollywood, FL 33021, United States.

Medical therapies in oncology have resulted in better survival resulting in a large population who are at risk of early and late cardiac complications of chemotherapy. Cardiotoxicity related to chemotherapy can manifest decades after treatment with a threefold higher mortality rate as compared to idiopathic dilated cardiomyopathy. The leading cause of death in cancer survivors seems to be cardiac. Read More

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http://dx.doi.org/10.1016/j.bbacli.2016.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925806PMC
December 2016

Generation of reactive oxygen species in the anterior eye segment. Synergistic codrugs of N-acetylcarnosine lubricant eye drops and mitochondria-targeted antioxidant act as a powerful therapeutic platform for the treatment of cataracts and primary open-angle glaucoma.

BBA Clin 2016 Dec 19;6:49-68. Epub 2016 Apr 19.

Innovative Vision Products, Inc., 3511 Silverside Road, Suite 105, County of New Castle, DE 19810, USA.

Senile cataract is a clouding of the lens in the aging eye leading to a decrease in vision. Symptoms may include faded colors, blurry vision, halos around light, trouble with bright lights, and trouble seeing at night. This may result in trouble driving, reading, or recognizing faces. Read More

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http://dx.doi.org/10.1016/j.bbacli.2016.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925929PMC
December 2016
2 Reads

Analysis of glutathione levels in the brain tissue samples from HIV-1-positive individuals and subject with Alzheimer's disease and its implication in the pathophysiology of the disease process.

BBA Clin 2016 Dec 29;6:38-44. Epub 2016 May 29.

Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA 91766, USA; Department of Basic Medical Sciences, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766-1854, USA.

HIV-1 positive individuals are at high risk for susceptibility to both pulmonary tuberculosis (TB) and extra-pulmonary TB, including TB meningitis (TBM) which is an extreme form of TB. The goals of this study are to determine the mechanisms responsible for compromised levels of glutathione (GSH) in the brain tissue samples derived from HIV-1-infected individuals and individuals with Alzheimer's disease (AD), investigate the possible underlying mechanisms responsible for GSH deficiency in these pathological conditions, and establish a link between GSH levels and pathophysiology of the disease processes. We demonstrated in the autopsied human brain tissues that the levels of total and reduced forms of GSH were significantly compromised in HIV-1 infected individuals compared to in healthy subjects and individuals with AD. Read More

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http://dx.doi.org/10.1016/j.bbacli.2016.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908271PMC
December 2016
5 Reads

Epigenetics in heart failure phenotypes.

BBA Clin 2016 Dec 30;6:31-7. Epub 2016 May 30.

Internal Medicine Department, State Medical University for Zaporozhye, 26, Mayakovsky Av., Zaporozhye, Postcode 69035, Ukraine.

Chronic heart failure (HF) is a leading clinical and public problem posing a higher risk of morbidity and mortality in different populations. HF appears to be in both phenotypic forms: HF with reduced left ventricular ejection fraction (HFrEF) and HF with preserved left ventricular ejection fraction (HFpEF). Although both HF phenotypes can be distinguished through clinical features, co-morbidity status, prediction score, and treatment, the clinical outcomes in patients with HFrEF and HFpEF are similar. Read More

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http://dx.doi.org/10.1016/j.bbacli.2016.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909708PMC
December 2016
2 Reads

Apoptotic and stress signaling markers are augmented in preeclamptic placenta and umbilical cord.

BBA Clin 2016 Dec 25;6:25-30. Epub 2016 May 25.

Department of Pediatrics, Baylor Scott & White Health, Texas A&M Health Science Center College of Medicine, Temple, TX, USA; Department of Obstetrics and Gynecology, Baylor Scott & White Health, Texas A&M Health Science Center College of Medicine, Temple, TX, USA; Department of Internal Medicine, Baylor Scott & White Health, Texas A&M Health Science Center College of Medicine, Temple, TX, USA.

Objective: Preeclampsia (preE) has a significant link to alterations of placental function leading to stress and apoptotic signaling, which pass the placental barrier and leave persistent defect in the circulation of the offspring. We assessed apoptotic signaling in placentas and umbilical cords from patients with and without preE.

Methods: We collected placental and cord tissues from 27 normal pregnant (NP) women and 20 preE consenting patients after delivery in an IRB approved prospective study. Read More

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http://dx.doi.org/10.1016/j.bbacli.2016.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906135PMC
December 2016
4 Reads