1,779,170 results match your criteria B E Journal Of Theoretical Economics[Journal]


Interaction between lifestyle behaviors and genetic polymorphism in SCAP gene on blood pressure among Chinese children.

Pediatr Res 2019 Apr 19. Epub 2019 Apr 19.

Institute of Child and Adolescent Health, School of Public Health, Peking University Health Science Center, 100191, Beijing, China.

Backgrounds: Previous studies had revealed that sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) rs12487736 polymorphism was associated with blood pressure (BP), but whether rs12487736 could interact with lifestyle behaviors on BP is unknown.

Methods: A case-control study with 1092 Chinese children was conducted.

Results: We found an interaction between rs12487736 and high calorie foods intake (fried chips/cakes/cookies) on systolic blood pressure (SBP) (P = 0. Read More

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http://dx.doi.org/10.1038/s41390-019-0402-zDOI Listing

Full tractography for detecting the position of cranial nerves in preoperative planning for skull base surgery: technical note.

J Neurosurg 2019 Apr 19:1-11. Epub 2019 Apr 19.

4Department of Neurosurgery, Stanford University Medical Center, Stanford, California.

OBJECTIVEDiffusion imaging tractography has allowed the in vivo description of brain white matter. One of its applications is preoperative planning for brain tumor resection. Due to a limited spatial and angular resolution, it is difficult for fiber tracking to delineate fiber crossing areas and small-scale structures, in particular brainstem tracts and cranial nerves. Read More

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http://dx.doi.org/10.3171/2019.1.JNS182638DOI Listing

Development of a C1q-immobilized (Cim) assay to measure total antibodies to infliximab and its clinical relevance in patients with inflammatory bowel disease.

Cytokine 2019 Apr 16;120:54-61. Epub 2019 Apr 16.

IBD Centre, Toho University Sakura Medical Centre, Chiba, Japan. Electronic address:

Objective: Determination of antibodies to infliximab (ATI) is desirable for the management of patients with inflammatory bowel disease (IBD) who receive infliximab. Conventional ligand-binding ATI-assays detect only free-form of ATI, potentially increasing the proportion of patients with undetectable ATI, but with adequate trough infliximab (TRI) level who experience loss of response (LOR) to infliximab. We investigated this assertion using a novel ATI-Cim assay. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.02.014DOI Listing

Neuroprotective effect of Dictyopteris divaricata extract-capped gold nanoparticles against oxygen and glucose deprivation/reoxygenation.

Colloids Surf B Biointerfaces 2019 Mar 29;179:421-428. Epub 2019 Mar 29.

Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Republic of Korea; Department of Laboratory Medicine, Pusan National University Hospital, Busan 49241, Republic of Korea.

Combination therapy remains a promising approach to ameliorate cerebral ischemia injury. Nevertheless, the primary mechanism of the neuroprotective properties of Dictyopteris divaricata extract-capped gold nanoparticles (DD-GNPs) is not completely understood. DD-GNPs displayed maximum absorption at 525 nm and a diameter of 62. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.03.066DOI Listing

Hippocampal BDNF signaling is required for the antidepressant effects of perillaldehyde.

Pharmacol Rep 2019 Jan 16;71(3):430-437. Epub 2019 Jan 16.

Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, Jiangxi Province, PR China. Electronic address:

Background: Perillaldehyde is one of the main components in perilla. Previous studies have shown that perillaldehyde exerted an antidepressant effect in mice, some of which is mediated through regulation of the anti-inflammatory system and the monoamine system. The primary objective of this study was to investigate the possible effects of perillaldehyde on the neurotrophic system and to elucidate whether its antidepressant effect requires brain-derived neurotrophic factor (BDNF) signaling. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.01.009DOI Listing
January 2019

The forgotten role of toxicodynamics: How habitat quality alters the mite, Oppia nitens, susceptibility to zinc, independent of toxicokinetics.

Chemosphere 2019 Apr 13;227:444-454. Epub 2019 Apr 13.

Toxicology Centre, University of Saskatchewan, Saskatoon, SK, Canada, S7N 5B3; Department of Soil Science, University of Saskatchewan, Saskatoon, SK, Canada, S7N 5A8.

Soil habitat quality is thought to influence metal toxicity via changes in speciation and thereby toxicokinetics. Here, we assessed the toxicokinetic and toxicodynamic effects of habitat quality on mite, Oppia nitens when exposed to zinc (Zn) contaminated soils. Forty-seven soils were ranked into three habitat qualities; high, medium, and low based on biological reproduction of Folsomia candida, Enchytraeus crypticus, and Elymus lanceolatus. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00456535193074
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http://dx.doi.org/10.1016/j.chemosphere.2019.04.090DOI Listing
April 2019
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Development Outcomes of Fadama III among Fish Farmers in Nigeria: Evidence from Lagos State.

Eval Program Plann 2019 Apr 3;75:10-19. Epub 2019 Apr 3.

Department of Agricultural Economics and Animal Production, University of Limpopo, South Africa. Electronic address:

This paper is focussed on the analysis of development outcomes of Fadama III programme among fish farmers in Nigeria with evidence from Lagos state. Random sampling technique was used to select 141 fish farmers from the Fadama III participants and non-participants from three agricultural divisions. Data were collected through structured questionnaire and analysed using descriptive statistics. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01497189183010
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http://dx.doi.org/10.1016/j.evalprogplan.2019.02.004DOI Listing
April 2019
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Picraviane A and B: Nortriterpenes with limonoid-like skeletons containing a heptanolide E-ring system from Picramnia glazioviana.

Phytochemistry 2019 Apr 16;163:38-45. Epub 2019 Apr 16.

Department of Drug Design and Pharmacology, University of Copenhagen, DK-2100, Copenhagen, Denmark. Electronic address:

Two highly oxygenated nortriterpenes, picraviane A and B, were isolated from the ethanolic extract of Picramnia glazioviana Engl. The structures were determined by analysis of HRMS and 2D NMR spectroscopic data. Single-crystal X-ray diffraction data was also obtained for picraviane B. Read More

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http://dx.doi.org/10.1016/j.phytochem.2019.03.024DOI Listing

Pulmonary nodule detection in CT scans with equivariant CNNs.

Med Image Anal 2019 Mar 28;55:15-26. Epub 2019 Mar 28.

University of Amsterdam, Netherlands.

Convolutional Neural Networks (CNNs) require a large amount of annotated data to learn from, which is often difficult to obtain for medical imaging problems. In this work we show that the sample complexity of CNNs can be significantly improved by using 3D roto-translation group convolutions instead of standard translational convolutions. 3D CNNs with group convolutions (3D G-CNNs) were applied to the problem of false positive reduction for pulmonary nodule detection in CT scans, and proved to be substantially more effective in terms of accuracy, sensitivity to malignant nodules, and speed of convergence compared to a strong and comparable baseline architecture with regular convolutions, extensive data augmentation and a similar number of parameters. Read More

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http://dx.doi.org/10.1016/j.media.2019.03.010DOI Listing

Age-dependent variations in the expression of myosin isoforms and myogenic factors during the involution of the proximal sesamoidean ligament of sheep.

Res Vet Sci 2019 Apr 11;124:270-279. Epub 2019 Apr 11.

Department of Comparative Biomedicine and Food Science, Università di Padova, Italy. Electronic address:

In ungulates the stability of the fetlock joint is dependent on several muscles, which are exposed to high stress and strain. Among those muscles, the proximal sesamoidean ligament or PSL (also known as the suspensory ligament or Ruini's elasto-tendinous organ) is organized at birth in layers of muscle fibres alternated with abundant tendinous tissue that, during the postnatal development, becomes the predominant tissue. In this study we analysed the PSL of the sheep at the age of 1, 30 and 180 days and determined the expression of several genes which either (a) are markers of muscle fibre growth and maturation, or (b) play a role as signal molecules. Read More

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http://dx.doi.org/10.1016/j.rvsc.2019.04.006DOI Listing

Blinatumomab for Acute Lymphoblastic Leukemia Relapse After Allogeneic Hematopoietic Stem Cell Transplantation.

Biol Blood Marrow Transplant 2019 Apr 16. Epub 2019 Apr 16.

Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Würzburg, Germany.

Patients with relapsed/refractory (R/R) acute lymphoblastic leukemia (ALL) following allogeneic hematopoietic stem cell transplantation (alloHSCT) have a poor prognosis, and alternative therapies are needed for this patient population. Blinatumomab, a bispecific T-cell engager immunotherapy, was evaluated in an open-label, single-arm, phase 2 study of adults with R/R Philadelphia chromosomenegative B-cell precursor ALL and resulted in a complete remission (CR) or CR with partial hematologic recovery of peripheral blood counts (CRh) rate of 43% within 2 treatment cycles. We conducted an exploratory analysis to determine the efficacy and safety of blinatumomab in 64 patients who had relapsed following alloHSCT prior to enrollment in the phase 2 study. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.04.010DOI Listing

Effects of interpretation bias modification on unregulated and regulated emotional reactivity.

J Behav Ther Exp Psychiatry 2019 Apr 3;64:123-132. Epub 2019 Apr 3.

ADAPT lab, Department of Psychology, University of Amsterdam, Nieuwe Achtergracht 129-B, 1018 WT, Amsterdam, the Netherlands; Department of Child Development and Education, University of Amsterdam, Nieuwe Achtergracht 129-B, 1018 WT, Amsterdam, the Netherlands. Electronic address:

Background And Objectives: Although induced changes in interpretation bias can lead to reduced levels of stress reactivity, results are often inconsistent. One possible cause of the inconsistencies in the effects of interpretation bias modification (IBM) on stress reactivity is the degree to which participants engaged in emotion regulation while being exposed to stressors. In this study, we distinguished between the effects of IBM on natural, unregulated stress reactivity and the effects of IBM on people's ability to up- or downregulate this stress reactivity. Read More

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http://dx.doi.org/10.1016/j.jbtep.2019.03.009DOI Listing

A proteomic and biochemical investigation on the effects of sulfadiazine in Arabidopsis thaliana.

Ecotoxicol Environ Saf 2019 Apr 16;178:146-158. Epub 2019 Apr 16.

DAFNAE, University of Padova, Viale Università 16, 30520 Legnaro, PD, Italy.

Animal manure or bio-solids used as fertilizers are the main routes of antibiotic exposure in the agricultural land, which can have immense detrimental effects on plants. Sulfadiazine (SDZ), belonging to the class of sulfonamides, is one of the most detected antibiotics in the agricultural soil. In this study, the effect of SDZ on the growth, changes in antioxidant metabolite content and enzyme activities related to oxidative stress were analysed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01476513193042
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http://dx.doi.org/10.1016/j.ecoenv.2019.04.008DOI Listing
April 2019
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Staphylococcus aureus versus neutrophil: Scrutiny of ancient combat.

Microb Pathog 2019 Apr 16. Epub 2019 Apr 16.

Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Staphylococcus aureus (S.aureus) is a Gram-positive bacterium that causes many infections and diseases. This pathogen can cause many types of infections such as impetigo, toxic shock syndrome toxin (TSST1), pneumonia, endocarditis, and autoimmune diseases like lupus erythematosus and can infect other healthy individuals. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08824010193037
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http://dx.doi.org/10.1016/j.micpath.2019.04.026DOI Listing
April 2019
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Biosynthesis of long-chain polyunsaturated fatty acids in the razor clam Sinonovacula constricta: Characterization of four fatty acyl elongases and a novel desaturase capacity.

Biochim Biophys Acta Mol Cell Biol Lipids 2019 Apr 16. Epub 2019 Apr 16.

Key Laboratory of Applied Marine Biotechnology, Ningbo University, Ministry of Education of China, Ningbo, Zhejiang 315211, China. Electronic address:

As an unusual economically important aquaculture species, Sinonovacula constricta possesses high levels of long-chain polyunsaturated fatty acids (LC-PUFA). Previously, our group identified fatty acyl desaturases (Fad) with Δ5 and Δ6 activities in S. constricta, which was the first report of Δ6 Fad in a marine mollusc. Read More

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http://dx.doi.org/10.1016/j.bbalip.2019.04.004DOI Listing

"I was considering surgery because I believed that was how it was treated": A qualitative study on willingness for joint surgery after completion of a digital management program for osteoarthritis.

Osteoarthritis Cartilage 2019 Apr 16. Epub 2019 Apr 16.

Department of Health Sciences, Lund University, Lund, Sweden; The PRO-CARE Group, School of Health and Society, Kristianstad University, Kristianstad, Sweden.

Objective: To explore, using a qualitative approach, reasons for patients' continued willingness or their shift in willingness for total joint replacement (TJR) surgery, following participation in Joint Academy, a Swedish, digital, non-surgical treatment program for osteoarthritis (OA).

Design: Nineteen patients with hip or knee OA were interviewed after finishing their first six weeks in the treatment program, using a semi-structured interview guide. The interviews were transcribed verbatim and analyzed using a systematic text condensation method. Read More

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http://dx.doi.org/10.1016/j.joca.2019.04.004DOI Listing

Identification of the anchoring protein SpoIIIJ for construction of the microbial cell surface display system in Bacillus spp.

Int J Biol Macromol 2019 Apr 16. Epub 2019 Apr 16.

Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China. Electronic address:

Microbial cell surface display technology is a powerful tool for displaying proteins on the surfaces of cells. However, few anchoring proteins can be employed for the display of target proteins on the cell surface of the environmentally benign Gram-positive bacterium Bacillus subtilis. In this study, bioinformatics tools were used to screen all of the encoded proteins of B. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.033DOI Listing

Effect of estradiol on hepatopancreatic lipid metabolism in the swimming crab, Portunus trituberculatus.

Gen Comp Endocrinol 2019 Apr 16. Epub 2019 Apr 16.

Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean University, Shanghai 201306, China; Centre for Research on Environmental Ecology and Fish Nutrition of Ministry of Agriculture and Rural Affairs, Shanghai Ocean University, Shanghai, 201306, China; National Demonstration Centre for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai 201306, China. Electronic address:

Estradiol is an important sex steroid hormone that involved in regulation of animal lipid metabolism. However, the effect of estradiol on lipid metabolism in swimming crab (Portunus trituberculatus) is unclear. The present study investigated the effect of four concentrations of exogenous estradiol (0, 0. Read More

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http://dx.doi.org/10.1016/j.ygcen.2019.04.019DOI Listing

B Cell Responses: Cell Interaction Dynamics and Decisions.

Cell 2019 Apr;177(3):524-540

Cardiovascular Research Institute, Department of Anatomy, and Sandler Asthma Basic Research Center, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

B cells and the antibodies they produce have a deeply penetrating influence on human physiology. Here, we review current understanding of how B cell responses are initiated; the different paths to generate short- and long-lived plasma cells, germinal center cells, and memory cells; and how each path impacts antibody diversity, selectivity, and affinity. We discuss how basic research is informing efforts to generate vaccines that induce broadly neutralizing antibodies against viral pathogens, revealing the special features associated with allergen-reactive IgE responses and uncovering the antibody-independent mechanisms by which B cells contribute to health and disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00928674193027
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http://dx.doi.org/10.1016/j.cell.2019.03.016DOI Listing
April 2019
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Direct Detection of Tissue-Resident Bacteria and Chronic Inflammation in the Bladder Wall of Postmenopausal Women with Recurrent Urinary Tract Infection.

J Mol Biol 2019 Apr 16. Epub 2019 Apr 16.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, United States of America; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, 75390, United States of America; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, 75390, United States of America. Electronic address:

Urinary tract infections (UTIs) are the most commonly reported infections in adult women and have high rates of recurrence, especially in postmenopausal women. Recurrent UTI (RUTI) greatly reduces quality of life, places a significant burden on the healthcare system, and contributes to antimicrobial resistance. Because treatment of RUTI by long-term antibiotic therapy is often ineffective or poorly tolerated in elderly women, new therapies must be developed. Read More

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http://dx.doi.org/10.1016/j.jmb.2019.04.008DOI Listing

Semen quality is affected by HLA class I alleles together with sexually transmitted diseases.

Andrology 2019 Apr 19. Epub 2019 Apr 19.

Instituto de Investigação e Inovação em Saúde, Universidade do Porto (i3S), Porto, Portugal.

Background: The human leukocyte antigen (HLA) locus includes several genes with key roles in antigen presentation and immune response, some of them inclusively found to be associated with non-obstructive azoospermia. Still, HLA connections to other infertility phenotypes such as semen hyperviscosity (SHV), asthenozoospermia (AST), and oligozoospermia (OLI) have been often neglected.

Objectives: In this work, we aimed to evaluate the association of HLA class I and II genes with SHV, AST, and OLI phenotypes while exploring a possible role in an adaptive immune response to sexually transmitted diseases (STD). Read More

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http://dx.doi.org/10.1111/andr.12625DOI Listing

Antifibrinolytic therapy for preventing oral bleeding in patients with haemophilia or Von Willebrand disease undergoing minor oral surgery or dental extractions.

Cochrane Database Syst Rev 2019 Apr 19;4:CD011385. Epub 2019 Apr 19.

Van Creveldkliniek / Department of Haematology, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht, Netherlands, 3584CT.

Background: Minor oral surgery or dental extractions (oral or dental procedures) are widely performed and can be complicated by hazardous oral bleeding, especially in people with an inherited bleeding disorder such as haemophilia or Von Willebrand disease (VWD). The amount and severity of singular bleedings depend on disease-related factors, such as the severity of the haemophilia, both local and systemic patient factors (such as periodontal inflammation, vasculopathy or platelet dysfunction) and intervention-related factors (such as the type and number of teeth extracted or the dimension of the wound surface). Similar to local haemostatic measures and suturing, antifibrinolytic therapy is a cheap, safe and potentially effective treatment to prevent bleeding complications in individuals with bleeding disorders undergoing oral or dental procedures. Read More

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http://dx.doi.org/10.1002/14651858.CD011385.pub3DOI Listing

Impact of malaria and hepatitis B co-infection on clinical and cytokine profiles among pregnant women.

PLoS One 2019 19;14(4):e0215550. Epub 2019 Apr 19.

West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Legon- Accra, Ghana.

Background: The overlap of malaria and chronic hepatitis B (CHB) is common in endemic regions, however, it is not known if this co-infection could adversely influence clinical and immunological responses. This study investigated these interactions in pregnant women reporting to antenatal clinics in Ghana.

Methods: Clinical parameters (hemoglobin, liver function biomarker, peripheral malaria parasitemia, and hepatitis B viremia) and cytokine profiles were assayed and compared across four categories of pregnant women: un-infected, mono-infected with Plasmodium falciparum (Malaria group), mono-infected with chronic hepatitis B virus (CHB group) and co-infected (Malaria+CHB group). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215550PLOS

Prevalence and genetic diversity of Burkholderia pseudomallei isolates in the environment near a patient's residence in Northeast Thailand.

PLoS Negl Trop Dis 2019 Apr 19;13(4):e0007348. Epub 2019 Apr 19.

Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Background: Burkholderia pseudomallei is the causative agent of melioidosis, a severe infectious disease in tropical regions. It is necessary to understand the risk of acquiring this infection from the environment.

Methodology /principal Findings: The prevalence, concentration and genetic diversity of B. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007348DOI Listing

Cardiometabolic risk factors in children born with marginally low birth weight: A longitudinal cohort study up to 7 years-of-age.

PLoS One 2019 19;14(4):e0215866. Epub 2019 Apr 19.

Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden.

Introduction: Low birth weight (LBW, <2500 g) may predict an increased risk of an adverse cardiometabolic profile later in life, but long-term effects in different populations and birth weight strata are still unclear. We explored laboratory markers of cardiometabolic risk in children born with marginally LBW (2000-2500 g).

Methods: This was a prospective longitudinal cohort study including 285 Swedish marginally LBW children and 95 normal birth weight (NBW, 2501-4500 g) controls. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215866PLOS

Lithium ameliorates tubule-interstitial injury through activation of the mTORC2/protein kinase B pathway.

PLoS One 2019 19;14(4):e0215871. Epub 2019 Apr 19.

Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

Tubule-interstitial injury (TII) is a critical step in the progression of renal disease. It has been proposed that changes in proximal tubule (PT) albumin endocytosis plays an important role in the development of TII. Some reports have shown protective effects of lithium on kidney injury animal models that was correlated to proteinuria. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215871PLOS

Sero-prevalence of Hepatitis B and C viral co-infections among HIV-1 infected ART-naïve individuals in Kumasi, Ghana.

PLoS One 2019 19;14(4):e0215377. Epub 2019 Apr 19.

Department of Clinical Microbiology, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

Background: The study assessed the hepatitis B virus (HBV) and hepatitis C virus (HCV) co-infection paradigm among the human immunodeficiency virus (HIV) infected patients attending a tertiary hospital in Ghana. Also, the immunological and virological characterisation of these viruses, prior to antiretroviral therapy (ART) initiation was investigated.

Method: A total of 400 HIV infected (HIV type-1) treatment naïve subjects ≥18 years were enrolled and tested for HBsAg and anti-HCV. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215377PLOS

Adjunctive dabigatran therapy improves outcome of experimental left-sided Staphylococcus aureus endocarditis.

PLoS One 2019 19;14(4):e0215333. Epub 2019 Apr 19.

Department of Clinical Microbiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

Background: Staphylococcus aureus is the most frequent and fatal cause of left-sided infective endocarditis (IE). New treatment strategies are needed to improve the outcome. S. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215333PLOS

Development of a risk score for earlier diagnosis of chronic kidney disease in children.

PLoS One 2019 19;14(4):e0215100. Epub 2019 Apr 19.

Nephrology Division, Federal University of Sao Paulo, Sao Paulo, Brazil.

Objective: To develop a clinical score for the early identification of chronic kidney disease (CKD) in children and adolescents. The early diagnosis of CKD in childhood allows the adoption of measures to slow the progression of the disease, thereby reducing morbidity and mortality. Nevertheless, the diagnosis is often made too late for proper patient management. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215100PLOS
April 2019
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Signatures of B-cell receptor diversity in B lymphocytes following Epstein-Barr virus transformation.

Physiol Genomics 2019 Apr 19. Epub 2019 Apr 19.

The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, China.

Epstein-Barr virus (EBV) is a widespread human virus that establishes latent infection, potentially leading to tumors, hematological disorders, and other severe diseases. EBV infections are associated with diverse symptoms and affect various organs; therefore, early diagnosis and treatment are crucial. B-cell receptor (BCR) repertoires of B cell surface immunoglobulins have been widely studied for their association with various infectious diseases. Read More

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http://dx.doi.org/10.1152/physiolgenomics.00124.2018DOI Listing

Enhancing Understanding of Moral Distress: The Measure of Moral Distress for Health Care Professionals.

AJOB Empir Bioeth 2019 Apr 19:1-12. Epub 2019 Apr 19.

e School of Nursing , Virginia Commonwealth University , Richmond , Virginia , USA.

Background: As ongoing research explores the impact of moral distress on health care professionals (HCPs) and organizations and seeks to develop effective interventions, valid and reliable instruments to measure moral distress are needed. This article describes the development and testing of a revision of the widely used Moral Distress Scale-Revised (MDS-R) to measure moral distress.

Methods: We revised the MDS-R by evaluating the combined data from 22 previous studies, assessing 301 write-in items and 209 root causes identified through moral distress consultation, and reviewing 14 recent publications from various professions in which root causes were described. Read More

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http://dx.doi.org/10.1080/23294515.2019.1586008DOI Listing

Preventive Misconception and Risk Behaviors in a Multinational HIV Prevention Trial.

AJOB Empir Bioeth 2019 Apr 19:1-9. Epub 2019 Apr 19.

b Department of Population Health Sciences , Duke University School of Medicine , Durham , North Carolina , USA.

Background: Some HIV prevention research participants may hold a "preventive misconception" (PM), an overestimate of the probability or level of personal protection afforded by trial participation. However, these reports typically rely upon small, retrospective qualitative assessments that did not use a standardized approach.

Methods: We administered a measure of PM called PREMIS, during Microbicide Trials Network 020-A Study to Prevent Infection with a Ring for Extended Use, a large, multicenter, placebo-controlled, phase III trial evaluating the safety and efficacy of a dapivirine vaginal ring among women at risk for HIV infection in Malawi, South Africa, Uganda, and Zimbabwe. Read More

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https://www.tandfonline.com/doi/full/10.1080/23294515.2019.1
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http://dx.doi.org/10.1080/23294515.2019.1593257DOI Listing
April 2019
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Pathways Into Homelessness Among LGBTQ2S Adults.

J Homosex 2019 Apr 19:1-19. Epub 2019 Apr 19.

b Centre for Research on Educational and Community Services and School of Psychology , University of Ottawa , Ottawa , Ontario , Canada.

This article examines entries into homelessness among adults who identify as LGBTQ2S (lesbian, gay, bisexual, transgender, queer, two-spirit). Twenty LGBTQ2S adults who were currently or formerly homeless participated in one qualitative interview. The interview protocol included questions on the participants' history of homelessness, causes of homelessness, and relationship of their gender and/or sexual identity to their homelessness. Read More

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https://www.tandfonline.com/doi/full/10.1080/00918369.2019.1
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http://dx.doi.org/10.1080/00918369.2019.1600902DOI Listing
April 2019
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A Remarkable Legacy: The Wayne F. Placek Fund Grant Program.

J Homosex 2019 Apr 19:1-10. Epub 2019 Apr 19.

c Executive Vice President/Executive Director , American Psychological Foundation , Washington , DC.

Gregory M. Herek, PhD, made an important professional contribution through his service as chair of the Scientific Review Committee of the Wayne F. Placek Fund of the American Psychological Foundation (APF). Read More

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https://www.tandfonline.com/doi/full/10.1080/00918369.2019.1
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http://dx.doi.org/10.1080/00918369.2019.1601437DOI Listing
April 2019
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Activated red mud as a permeable reactive barrier material for fluoride removal from groundwater: Parameter optimization and physico-chemical characterization.

Environ Technol 2019 Apr 19:1-39. Epub 2019 Apr 19.

a Department of Chemical Engineering , GMR Institute of Technology , Rajam 532 127 , Srikakulam , India.

The main aim of this work is to test the performance of red mud as a permeable reactive barrier (PRB) material for fluoride removal from water. Batch experiments were carried out to optimize the fluoride removal efficiency (RE) of activated red mud (ARM) based on four selected parameters, namely, the initial fluoride concentration (3-40 mg/L), adsorbent dose (0.5-5 g/L), pH (3. Read More

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http://dx.doi.org/10.1080/09593330.2019.1609591DOI Listing

Challenges and promise at the interface of metaproteomics and genomics: an overview of recent progress in metaproteogenomic data analysis.

Expert Rev Proteomics 2019 Apr 19. Epub 2019 Apr 19.

b VIB - UGent Center for Medical Biotechnology , Ghent , Belgium.

Introduction: The study of microbial communities based on the combined analysis of genomic and proteomic data - called metaproteogenomics - has gained increased research attention in recent years. This relatively young field aims to elucidate the functional and taxonomic interplay of proteins in microbiomes and its implications on human health and the environment. Areas covered: This article reviews bioinformatics methods and software tools dedicated to the analysis of data from metaproteomics and metaproteogenomics experiments. Read More

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http://dx.doi.org/10.1080/14789450.2019.1609944DOI Listing

Can we better strategize our choice of pharmacotherapy for patients with co-morbid psoriasis and obesity?

Expert Opin Pharmacother 2019 Apr 19:1-6. Epub 2019 Apr 19.

b 2nd Department of Dermatology and Venereal Diseases , Attikon General University Hospital, Medical School, National and Kapodistrian University of Athens , Athens , Greece.

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http://dx.doi.org/10.1080/14656566.2019.1603294DOI Listing

The circadian clock gene is required to control the timing of retinal neurogenesis and lamination of Müller glia in the mouse retina.

FASEB J 2019 Apr 19:fj201801832RR. Epub 2019 Apr 19.

Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA.

A single pool of multipotent retinal progenitor cells give rise to the diverse cell types within the mammalian retina. Such cellular diversity is due to precise control of various cellular processes like cell specification, proliferation, differentiation, and maturation. Circadian clock genes can control the expression of key regulators of cell cycle progression and therefore can synchronize the cell cycle state of a heterogeneous population of cells. Read More

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http://dx.doi.org/10.1096/fj.201801832RRDOI Listing

Evaluating crisaborole as a treatment option for atopic dermatitis.

Expert Opin Pharmacother 2019 Apr 19:1-7. Epub 2019 Apr 19.

d Department of Dermatology , Wake Forest School of Medicine , Winston-Salem , NC , USA.

Introduction: Atopic dermatitis (AD) is a chronic and recurrent disease presenting with eczematous lesions and pruritus. It impacts patient and family quality of life, increases morbidity, and accounts for large health-care expenditures. Although nonpharmacologic, topical, and systemic treatments exist, management of AD remains challenging due to limited treatment options. Read More

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http://dx.doi.org/10.1080/14656566.2019.1604688DOI Listing

What's new on therapies for elevated lipoprotein(a).

Expert Rev Clin Pharmacol 2019 Apr 19. Epub 2019 Apr 19.

b School of Medicine, Faculty of Health and Medical Sciences , University of Western Australia , Perth Australia.

Introduction: The study of microbial communities based on the combined analysis of genomic and proteomic data - called metaproteogenomics - has gained increased research attention in recent years. This relatively young field aims to elucidate the functional and taxonomic interplay of proteins in microbiomes and its implications on human health and the environment. Areas covered: This article reviews bioinformatics methods and software tools dedicated to the analysis of data from metaproteomics and metaproteogenomics experiments. Read More

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http://dx.doi.org/10.1080/17512433.2019.1610391DOI Listing

Differences in immunogenicity associated with non-product related variability: insights from two pharmacokinetic studies using GP2017, an adalimumab biosimilar.

Expert Opin Biol Ther 2019 Apr 19:1-8. Epub 2019 Apr 19.

a Global Clinical Development, Biopharmaceuticals , Hexal AG (A Sandoz Company) , Holzkirchen , Germany.

Introduction: Antidrug antibody (ADA) development is known to occur with adalimumab treatment and impacts adalimumab exposure. Here, we compare the impact of immunogenicity on pharmacokinetics (PK) across two randomized PK studies of GP2017, an approved biosimilar adalimumab, in healthy subjects.

Methods: Healthy male subjects (N= 107 in study GP17-104; N= 90 in study GP17-103) received a single 40 mg subcutaneous injection of the same GP2017 drug product batch. Read More

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http://dx.doi.org/10.1080/14712598.2019.1603959DOI Listing

Improvement of embryonic development and clinical outcomes of germinal vesicle stage oocytes using a microvibration culture system.

Syst Biol Reprod Med 2019 Apr 19:1-9. Epub 2019 Apr 19.

b Division of Biotechnology , College of Life Sciences and Biotechnology, Korea University , Seongbuk-gu , Seoul , Republic of Korea.

In vitro maturation (IVM) has evolved as a clinical treatment option in assisted reproductive technology. However, the poor developmental potential of germinal vesicle (GV)-stage oocytes is still suboptimal. This study's objective was to evaluate the effect of a microvibration culture system (MVC) during IVM and/or in vitro culture (IVC) on the clinical outcomes and the embryonic development potential of human GV-stage oocytes collected from human chorionic gonadotropin (HCG)-primed IVM and fertilization-embryo transfer (IVM/F-ET) cycles of patients with polycystic ovaries (PCO). Read More

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https://www.tandfonline.com/doi/full/10.1080/19396368.2019.1
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http://dx.doi.org/10.1080/19396368.2019.1602681DOI Listing
April 2019
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Upregulation of MicroRNA-21 promotes tumorigenesis of prostate cancer cells by targeting KLF5.

Cancer Biol Ther 2019 Apr 19:1-13. Epub 2019 Apr 19.

a Key Laboratory of Laboratory Medicine, Ministry of Education of China, Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Sciences , Wenzhou Medical University , Wenzhou , Zhejiang , China.

Prostate cancer (PCa) is the second frequently newly diagnosed cancer in men. Androgen deprivation therapy has been widely used to inhibit PCa growth but eventually fails in many patients. Androgen receptor and its downstream molecules like microRNAs could be promising therapeutic targets. Read More

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http://dx.doi.org/10.1080/15384047.2019.1599659DOI Listing

Pediatric drug safety signal detection of non-chemotherapy drug-induced neutropenia and agranulocytosis using electronic healthcare records.

Expert Opin Drug Saf 2019 Apr 19:1-7. Epub 2019 Apr 19.

a Clinical Research Center , National Center for Children's Health, Beijing Children's Hospital, Capital Medical University , Beijing , China.

Objectives: This study aimed to develop a procedure to explore the adverse drug reaction signals of drug-induced neutropenia (DIN) or drug-induced agranulocytosis (DIA) in children using an electronic health records (EHRs) database.

Methods: A two-stage design was presented. First, the suspected drugs to induce DIN or DIA were selected. Read More

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http://dx.doi.org/10.1080/14740338.2019.1604682DOI Listing

Mammary adipose stromal cells derived from obese women reduce sensitivity to the aromatase inhibitor anastrazole in an organotypic breast model.

FASEB J 2019 Apr 19:fj201802347RRR. Epub 2019 Apr 19.

Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Aromatase inhibitors are the preferred treatment for certain women with estrogen receptor (ER)-positive breast cancer, but evidence suggests that women with obesity experience aromatase inhibitor resistance at higher rates. To compare how stromal cells derived from women who are lean or obese influence response to the aromatase inhibitor (anastrazole), we incorporated patient-derived stroma in a previously characterized MCF7-derived duct model. Coculture with adipose stromal cells enabled the metabolism of testosterone (T) to E, which induced estrogen response element activity, epithelial proliferation, and hyperplasia in MCF7 cells. Read More

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http://dx.doi.org/10.1096/fj.201802347RRRDOI Listing

Quantitative Lipidomics in Pulmonary Alveolar Proteinosis.

Am J Respir Crit Care Med 2019 Apr 19. Epub 2019 Apr 19.

Regensburg University Hospital, Regensburg, Germany.

Rationale: Pulmonary alveolar proteinosis is characterized by filling of the alveolar spaces by lipoprotein rich material of ill-defined composition, and which is caused by molecularly different and often rare diseases occurring from birth to old age.

Objectives: Quantitative lipidomic analysis of lipids and surfactant proteins A, B and C from lavage fluids of patients with different causes of proteinosis in comparison to healthy contols.

Methods: During the last decades we collected alveolar lavage samples from patients with PAP due to autoantibodies against GMCSF, genetic mutations in CSF2RA, MARS, FARSB, NPC2 and secondary to myeloid leukemia. Read More

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https://www.atsjournals.org/doi/10.1164/rccm.201901-0086OC
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http://dx.doi.org/10.1164/rccm.201901-0086OCDOI Listing
April 2019
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A Framework for Conducting and Analyzing Crystal Simulations of Nucleic Acids to Aid in Modern Force Field Evaluation.

J Phys Chem B 2019 Apr 19. Epub 2019 Apr 19.

Crystal simulations provide useful tools, along with solution simulations, to test nucleic acid force fields, but should be interpreted with care owing to the difficulty of establishing the environmental conditions needed to reproduce experimental crystal packing. These challenges underscore the need to construct proper protocols for carrying out crystal simulations and analyzing results to identify the origin of deviations from crystallographic data. Toward this end, we introduce a novel framework for B-factor decomposition into additive intramolecular, rotational, and translational atomic fluctuation components, and partitioning of each of these components into individual asymmetric unit and lattice contributions. Read More

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http://dx.doi.org/10.1021/acs.jpcb.8b11923DOI Listing

Imidazole in Aqueous Solution: Hydrogen Bond Interactions and Structural Reorganization with Concentration.

J Phys Chem B 2019 Apr 19. Epub 2019 Apr 19.

The structural and dynamic properties of imidazole in aqueous solution have been studied by means of classical and ab initio molecular dynamics simulations. We developed a new force field for the imidazole molecule with improved modelling of the electrostatic interactions, specifically tailored to address the well known drawbacks of existing force fields based on the atomic fractional charges approach. To this end, we reparametrized the charge distribution on the heterocyclic ring, introducing an extra site accounting for the lone pair on the deprotonated nitrogen. Read More

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http://dx.doi.org/10.1021/acs.jpcb.9b01611DOI Listing

Time-Resolved Photochemistry of Stiffened Stilbenes.

J Phys Chem B 2019 Apr 19. Epub 2019 Apr 19.

Broadband transient absorption spectroscopy is used to study the photoisomerization of stiffened stilbene derivatives in solution, an E/Z mixture of bis(benzocyclobutylidene) (t4, c4) and (E)-1-(2,2-dimethyltetralinylidene)-2-2-dimethyltetraline (t6). Upon excitation to S, all evolve to perpendicular molecular conformation P, followed by decay to S, but the exact kinetic behavior crucially depends on the type of the stiffening ring. In 4, the S→ P torsion is characterized by the two distinct time constants of 172 and 77 ps in n-hexane, or 116 and 44 ps in acetonitrile. Read More

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http://pubs.acs.org/doi/10.1021/acs.jpcb.9b00784
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http://dx.doi.org/10.1021/acs.jpcb.9b00784DOI Listing
April 2019
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Novel Measures of Benzodiazepine and Z-Drug Utilisation Trends in a Canadian Provincial Adult Population (2001-2016).

J Popul Ther Clin Pharmacol 2019 Jan 22;26(1):e22-e38. Epub 2019 Jan 22.

College of Pharmacy, University of Manitoba.

Purpose:  1) To evaluate trends for benzodiazepines (BZD) and Z-Drugs over 15-years in a general Canadian adult population measured by: a) consumption b) pharmacologic exposure c) dose intensity and d) prevalence of use. 2) To demonstrate the utility of Diazepam Milligram Equivalence (DME) based measurements when used in conjunction with traditional standard measurements of drug utilization such as the Defined Daily Dose (DDD) system.

Methods: Administrative data covering all prescriptions from April 2001-March 2016 for BZD and Z-Drugs for patients ≥18 years was used. Read More

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http://www.jptcp.com/index.php/jptcp/article/view/52
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http://dx.doi.org/10.22374/1710-6222.26.1.3DOI Listing
January 2019
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