1,890,442 results match your criteria B E Journal Of Theoretical Economics[Journal]


Covid-19 pandemic: Infection control in dental health care of infected patients-a state concept.

Oral Dis 2020 Jul 2. Epub 2020 Jul 2.

Clinic of Oral and Maxillofacial Surgery, University Hospital Schleswig-Holstein, Campus Kiel, Arnold-Heller-Str. 3, Building B, 24105, Kiel, Germany.

In December 2019 an outbreak of a new corona virus was reported in the city Wuhan, China. End of January, the WHO declared this development as a public health emergency of international concern (WHO, 2020). Germany reported a rapidly increasing number of 186,461 infected persons in the period from February to June (Robert-Koch-Institut, 2020). Read More

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http://dx.doi.org/10.1111/odi.13529DOI Listing

A behind the scenes tour of the IEDB curation process: an optimized process empirically integrating automation and human curation efforts.

Immunology 2020 Jul 2. Epub 2020 Jul 2.

Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA, 92037, USA.

The Immune Epitope Database and Analysis Resource (IEDB) provides the scientific community open access to epitope data, as well as epitope prediction and analysis tools. The IEDB houses the most extensive collection of experimentally validated B cell and T cell epitope data, sourced primarily from published literature by expert curation. The data procurement requires systematic identification, categorization, curation, and quality-checking processes. Read More

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http://dx.doi.org/10.1111/imm.13234DOI Listing

Structured Reporting of Solid and Cystic Pancreatic Lesions in CT and MRI: Consensus-Based Structured Report Templates of the German Society of Radiology (DRG).

Rofo 2020 Jul 2;192(7):641-656. Epub 2020 Jul 2.

Department of Radiology, Clemens-Hospital GmbH Münster, Germany.

Background:  Radiological reports of pancreatic lesions are currently widely formulated as free texts. However, for optimal characterization, staging and operation planning, a wide range of information is required but is sometimes not captured comprehensively. Structured reporting offers the potential for improvement in terms of completeness, reproducibility and clarity of interdisciplinary communication. Read More

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http://dx.doi.org/10.1055/a-1150-8217DOI Listing

[Hepatolienal candidosis as a rare differential diagnosis of disseminated small parenchym lesions].

Dtsch Med Wochenschr 2020 Jul 2;145(13):912-916. Epub 2020 Jul 2.

Klinik für Diagnostische und Interventionelle Radiologie, Uniklinikum Ulm, Ulm.

History:  We report about a 17-year-old patient with the secondary malignancy of acute myeloid leukemia (AML). He developed fever of unclear origin during the hematopoietic stem cell transplantation.History We report about a 17-year-old patient with the secondary malignancy of acute myeloid leukemia (AML). Read More

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http://dx.doi.org/10.1055/a-1164-0043DOI Listing

Monogenic Primary Immunodeficiency Disorder Associated with Common Variable Immunodeficiency and Autoimmunity.

Int Arch Allergy Immunol 2020 Jul 2:1-9. Epub 2020 Jul 2.

Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Science, Tehran, Iran,

Background: Common variable immunodeficiency (CVID) is the most frequent primary immunodeficiency disorder mainly characterized by recurrent bacterial infections besides other immunological defects including loss of or dysfunction of B cells and decreased immunoglobulin levels. In this study, our aim is to evaluate clinical, immunological, and molecular data of patients with a primary clinical diagnosis of CVID and autoimmune phenotype with a confirmed genetic diagnosis.

Methods: Among 297 patients with CVID, who were registered in the Iranian Primary Immunodeficiency Registry at Children's Medical Center Hospital in Iran, 83 patients have been genetically examined and 27 patients with autoimmunity and confirmed genetic mutations were selected for analysis. Read More

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http://dx.doi.org/10.1159/000508817DOI Listing

Simultaneous determination of olaquindox, oxytetracycline and chlorotetracycline in feeds by high performance liquid chromatography with ultraviolet and fluorescence detection adopting online synchronous derivation and separation.

J Chromatogr B Analyt Technol Biomed Life Sci 2020 Jun 21;1152:122253. Epub 2020 Jun 21.

Test Center, Wellhope Agri-Tech Joint Stock Co., Ltd, Shenyang, Liaoning Province, PR China.

Olaquindox, oxytetracycline and chlorotetracycline were widely used in feed as antibiotics and growth promoter to improve feed conversion efficiency and increase the rate of weight gain for animals. However, the use of these antibiotics in feed was gradually prohibited because of concerns about contamination and resistance in animals. A quantitative and confirmatory method for determining the presence of olaquindox, oxytetracycline and chlorotetracycline in feed by high performance liquid chromatography equipped with ultraviolet detector in series with fluorescence detector (HPLC-UVD-FLD) was developed, optimized, and validated in three different matrices (compound, concentrated and premix feed). Read More

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http://dx.doi.org/10.1016/j.jchromb.2020.122253DOI Listing

Simultaneous quantification of endocannabinoids, oleoylethanolamide and steroid hormones in human plasma and saliva.

J Chromatogr B Analyt Technol Biomed Life Sci 2020 Jun 20;1152:122252. Epub 2020 Jun 20.

Central Science Laboratory, University of Tasmania, Australia.

Endogenous cannabinoids are an increasingly intriguing target for biological research, given the changing legal status of medicinal cannabinoid-based products throughout the world. However, studying the endogenous cannabinoid system is a relatively new field, with few research teams attempting to develop quantitative methods for these important modulatory analytes in human matrices, other than blood. Here we develop and validate simultaneous methods for quantifying arachidonoyl-ethanolamide, 2-arachidonoyl glycerol, oleoylethanolamide, cortisol and progesterone in human plasma and saliva using liquid-liquid extraction combined with ultra-high performance liquid chromatography coupled to tandem mass spectrometry. Read More

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http://dx.doi.org/10.1016/j.jchromb.2020.122252DOI Listing

Two rapid, accurate liquid chromatography tandem mass spectrometry methods for the quantification of seven uremic toxins: An application for describing their accumulation kinetic profile in a context of acute kidney injury.

J Chromatogr B Analyt Technol Biomed Life Sci 2020 Jun 13;1152:122234. Epub 2020 Jun 13.

EA 7517 MP3CV, UPJV, F-80054 Amiens, France; Laboratory of Pharmacology and Toxicology, Amiens-Picardie University Hospital, F-80054 Amiens, France. Electronic address:

Acute kidney injury (AKI) is a frequent, serious complication in critically ill patients. Even if renal replacement therapy is rapidly initiated, AKI may lead to the acute accumulation of metabolic waste products called uremic toxins (UTs). Although the accumulation and effects of UTs have been extensively described in the setting of chronic kidney disease (CKD), few data are available for AKI. Read More

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http://dx.doi.org/10.1016/j.jchromb.2020.122234DOI Listing

Development and validation of a combined enzymatic-digestion/mass spectrometry assay for Tacrolimus quantitation in cardiac biopsies.

J Chromatogr B Analyt Technol Biomed Life Sci 2020 Jun 21;1152:122215. Epub 2020 Jun 21.

Clinical and Experimental Pharmacokinetics Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. Electronic address:

Recent studies report strategies for analysing immunosuppressive drugs in brain, liver and renal tissue, mostly in animals: we developed and validated a two steps combined enzymatic digestion/mass spectrometry assay to quantify Tacrolimus (TAC) in heart biopsies. Our aims were to avoid sample loss and sample contamination during the laboratory preparation, and to limit matrix effects in the electrospray ionization source (ESI) of the mass spectrometer. Enzymatic tissue digestion followed by a liquid-liquid drug extraction in the same vial of reaction allowed us to reach both our aims. Read More

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http://dx.doi.org/10.1016/j.jchromb.2020.122215DOI Listing

Isolation of glycosylinositol phosphoceramide and phytoceramide 1-phosphate in plants and their chemical stabilities.

J Chromatogr B Analyt Technol Biomed Life Sci 2020 Jun 12;1152:122213. Epub 2020 Jun 12.

Graduate School of Technology, Industrial and Social Sciences, Tokushima University, Tokushima 770-8513, Japan. Electronic address:

Glycosylinositol phosphoceramide (GIPC) is a sphingophospholipid in plants. Recently, we identified that GIPC is hydrolyzed to phytoceramide 1-phosphate (PC1P) by an uncharacterized phospholipase D activity following homogenization of certain plant tissues. We now developed methods for isolation of GIPC and PC1P from plant tissues and characterized their chemical stabilities. Read More

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http://dx.doi.org/10.1016/j.jchromb.2020.122213DOI Listing

LC-MS/MS method for quantitation of the CK2 inhibitor silmitasertib (CX-4945) in human plasma, CSF, and brain tissue, and application to a clinical pharmacokinetic study in children with brain tumors.

J Chromatogr B Analyt Technol Biomed Life Sci 2020 Jun 23;1152:122254. Epub 2020 Jun 23.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, United States. Electronic address:

Silmitasertib (CX-4945) as a potent and selective inhibitor of CK2 exhibited promising in vitro and in vivo anti-cancer activity. An assay employing cation-exchange solid phase extraction (SPE) followed by LC-MS/MS analysis was successfully developed and validated for the quantitation of silmitasertib in human plasma, brain tissue, and human cerebrospinal fluid (CSF). Reverse phase chromatographic separation was achieved using Synergi™ hydro-RP column (4 μm, 75 × 2. Read More

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http://dx.doi.org/10.1016/j.jchromb.2020.122254DOI Listing

c-Phycocyanin primed silver nano conjugates: Studies on red blood cell stress resilience mechanism.

Colloids Surf B Biointerfaces 2020 Jun 25;194:111211. Epub 2020 Jun 25.

Department of Applied Physiology, School of Medicine, University of Miyazaki, Miyazaki, 889 1692, Japan.

Green synthesis of metal-encased nutraceutical nano-hybrids has been a target for research over the last few years. In the present investigation, we have reported temperature dependent facile synthesis of silver nanoparticles using FDA approved c phycocyanin (cPC). The cPC conjugated silver nanoparticles (AgcPCNPs) were characterized by TEM, Zeta Potential, UV-vis, XPS, FTIR, and CD Spectroscopy. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2020.111211DOI Listing

Control of microbial biofilm formation as an approach for biomaterials synthesis.

Colloids Surf B Biointerfaces 2020 Jun 16;194:111201. Epub 2020 Jun 16.

Planta Piloto de Procesos Industriales Microbiológicos (PROIMI), CONICET, Av. Belgrano y Pasaje Caseros, T4001 MVB, Tucumán Fac. Bioq., Qca. y Farmacia (UNT), Ayacucho 471, 4000, Tucumán, Argentina. Electronic address:

The search for new biomaterials with superior mechanical properties is the focus in the area of materials science. A promising pathway is drawing inspiration from nature to design and develop materials with enhanced properties. In this work, a novel strategy to produce functionalized supramolecular bionanomaterials from the microbial biofilm is reported. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2020.111201DOI Listing

ROS triggered cleavage of thioketal moiety to dissociate prodrug nanoparticles for chemotherapy.

Colloids Surf B Biointerfaces 2020 Jun 25;194:111223. Epub 2020 Jun 25.

National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China. Electronic address:

With the utilization of high concentration reactive oxygen species (ROS) in tumor microenvironment, PEG-doxorubicin (PEG-DOX) prodrug was synthesized via a thioketal moiety as the linker, which was ROS cleavable to trigger DOX release from the self-assembled prodrug nanoparticles. The in vitro ROS sensitivity of prodrug nanoparticles (NPs) was investigated in Fenton agent and HO, and the disassembly of NPs was more sensitive to Fenton reagent. After internalized in HepG2 cells via endocytosis, the cellular ROS consuming test revealed intracellular DOX release. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2020.111223DOI Listing

Sex-specific differences in rim appearance of multiple sclerosis lesions on quantitative susceptibility mapping.

Mult Scler Relat Disord 2020 Jun 18;45:102317. Epub 2020 Jun 18.

University of Maryland School of Medicine, Baltimore, MD, United States; Department of Neurology Johns Hopkins University School of Medicine, Baltimore, MD, United States; Department of Neurology, University of Maryland School of Medicine, 110 South Paca Street, 3(rd) Floor, Baltimore, Maryland 201201. Electronic address:

Background: Susceptibility MRI techniques, such as phase and quantitative susceptibility mapping (QSM) reveal lesion heterogeneity in MS, including the presence of lesions with outer rims suggestive of iron accumulation in macrophages and microglia, indicative of chronic-active inflammatory white matter lesions (WMLs).

Objective: To evaluate the in vivo relationship between chronic-active WMLs (as visualized by rimmed lesions on QSM) and several clinical metrics.

Methods: 39 patients (15 men, 24 women) with MS underwent 7 Tesla brain MRIs and clinical evaluation. Read More

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http://dx.doi.org/10.1016/j.msard.2020.102317DOI Listing

Why is CarH photolytically active in comparison to other B-dependent enzymes?

J Photochem Photobiol B 2020 May 28;209:111919. Epub 2020 May 28.

Department of Chemistry, University of Louisville, Louisville, KY 40292, United States of America. Electronic address:

The discovery of naturally occurring B-depedent photoreceptors has allowed for applications of cobalamins (Cbls) in optogenetics and synthetic biology to emerge. However, theoretical investigations of the complex mechanisms of these systems have been lacking. Adenosylcobalamin (AdoCbl)-dependent photoreceptor, CarH, is one example and it relies on daylight to perform its catalytic function. Read More

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http://dx.doi.org/10.1016/j.jphotobiol.2020.111919DOI Listing

Highly chemoselective turn-on fluorescent probe for ferrous (Fe) ion detection in cosmetics and live cells.

J Photochem Photobiol B 2020 Jun 24;209:111943. Epub 2020 Jun 24.

Amrita Centre for Industrial Research &Innovation, Amrita School of Engineering, Coimbatore 641112, Amrita Vishwa Vidyapeetham, India; Departmentof Chemical Engineering & Materials Science, Amrita School of Engineering, Coimbatore 641112, Amrita Vishwa Vidyapeetham, India. Electronic address:

In modern society, the use of cosmetics has increased extensively; unfortunately, so-called several toxic metal salts are present as the colorant or filler in cosmetics. The ferrous ion (Fe) is one of the metal ions used in cosmetics as a colorant. Ferrous ion (Fe) is a vital component in live cells. Read More

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http://dx.doi.org/10.1016/j.jphotobiol.2020.111943DOI Listing

Listeners' adaptation to unreliable intonation is speaker-sensitive.

Cognition 2020 Jun 29;204:104372. Epub 2020 Jun 29.

University of Cologne, IfL-Phonetik, Herbert-Lewin-Str 6, 50931 Köln, Germany. Electronic address:

Variable linguistic environments require the ability to quickly update expectations and behavior including speech comprehension. This adaptive capacity is key to understanding how listeners successfully recognize speaker intentions in light of the ubiquitous variability in speech. The present study investigates how listeners' real-time sentence comprehension adapts to speaker-specific prosodic variability. Read More

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http://dx.doi.org/10.1016/j.cognition.2020.104372DOI Listing

Prenylated chromones and flavonoids from Artocarpus heterophyllus with their potential antiproliferative and anti-inflammatory activities.

Bioorg Chem 2020 Jun 20;101:104030. Epub 2020 Jun 20.

Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China; Engineering Research Center for Industrialization of Southern Medicinal Plants Resources of Hainan Province, Hainan Normal University, Haikou 571158, PR China; Key Laboratory of Southern Medicinal Plants Resources of Haikou City, Hainan Normal University, Haikou 571158, PR China; Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Hainan Normal University, Haikou 571158, PR China. Electronic address:

Two new prenylated chromones, artoheterophines A (1) and B (2), five known prenylated chromones (3-7), as well as five known biogenetically related prenylated flavonoids (8-12) were isolated and characterized from the stems and leaves of A. heterophyllus. Their chemical structures were unambiguously determined through comprehensive spectral data analyses. Read More

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http://dx.doi.org/10.1016/j.bioorg.2020.104030DOI Listing

The effect of baclofen on objective and subjective sleep measures in a model of transient insomnia.

Sleep Med 2020 Apr 4;72:130-134. Epub 2020 Apr 4.

University of Oklahoma Health Sciences Center, Lynn Health Science Institute, Oklahoma City, OK, USA. Electronic address:

Study Objectives: Insomnia is a common medical complaint. Current pharmacologic treatments have modest efficacy and numerous side effects. Baclofen is a gamma-aminobutyric acid (GABA)b receptor agonist used to treat spasticity in various medical conditions. Read More

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http://dx.doi.org/10.1016/j.sleep.2020.03.028DOI Listing

Assessment of reproductive and developmental effects of graphene oxide on Japanese medaka (Oryzias latipes).

Chemosphere 2020 Jun 22;259:127221. Epub 2020 Jun 22.

RCMI Center for Environmental Health, Jackson State University, Jackson, MS, 39217, USA. Electronic address:

Due to its unique properties, graphene oxide (GO) has potential for biomedical and electronic applications, however environmental contamination including aquatic ecosystem is inevitable. Moreover, potential risks of GO in aquatic life are inadequately explored. Present study was designed to evaluate GO as an endocrine disrupting chemical (EDC) using the model Japanese medaka (Oryzias latipes). Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.127221DOI Listing

Two plant growth promoting bacterial Bacillus strains possess different mechanisms in adsorption and resistance to cadmium.

Sci Total Environ 2020 Jun 23;741:140422. Epub 2020 Jun 23.

School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China; Key Laboratory of Urban Agriculture, Ministry of Agriculture and Rural Areas, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address:

Microorganisms are promising biosorbents for decontaminating cadmium-polluted soil or water systems, but the underlying remediation mechanisms are still unclear. In this study, the cadmium biosorption mechanisms and capabilities of plant growth-promoting microorganisms (Bacillus megaterium NCT-2 and Bacillus paranthracis NT1) were investigated. Batch biosorption experiments showed that the optimal biosorption conditions for B. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.140422DOI Listing

Fate of antibiotics and antibiotic resistance genes during conventional and additional treatment technologies in wastewater treatment plants.

Sci Total Environ 2020 Jun 16;741:140199. Epub 2020 Jun 16.

Department of Environmental Technology, Wageningen University & Research, P.O. Box 17, 6700 AA Wageningen, the Netherlands. Electronic address:

Information on the removal of antibiotics and ARGs in full-scale WWTPs (with or without additional treatment technology) is limited. However, it is important to understand the efficiency of full-scale treatment technologies in removing antibiotics and ARGs under a variety of conditions relevant for practice to reduce their environmental spreading. Therefore, this study was performed to evaluate the removal of antibiotics and ARGs in a conventional wastewater treatment plant (WWTP A) and two full-scale combined with additional treatment technologies. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.140199DOI Listing

Stimulation with FITC-labeled antigens confers B cells with regulatory properties.

Cell Immunol 2020 Jun 12;355:104151. Epub 2020 Jun 12.

Centre de recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, F-75006 Paris, France.

B cells with regulatory properties (Bregs) were identified in human and in mice among different B-cell subsets. Their regulatory properties rely mainly on the production of anti-inflammatory cytokines, in particular IL10, IL-35 and TGFβ, and were extensively studied in mouse models of autoimmune and inflammatory diseases. However, the exact nature of the stimulatory signals conferring regulatory properties to B cells is still not clear. Read More

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http://dx.doi.org/10.1016/j.cellimm.2020.104151DOI Listing

Combined effect of acoustic cavitation and pulsed discharge plasma on wastewater treatment efficiency in a circulating reactor: A case study of Rhodamine B.

Ultrason Sonochem 2020 Jun 23;68:105236. Epub 2020 Jun 23.

Department of Frontier Science for Advanced Environment, Tohoku University, 980-8579, Japan.

The present study investigates the wastewater treatment performance of an acoustic cavitation assisted plasma (ACAP) process in a circulating reactor using Rhodamine B (RhB) as a model water pollution. The concept of this process was proposed by the authors recently for a batch type rector. The measurements revealed that combining the ultrasound irradiation with pulsed discharge plasma allows the RhB degradation efficiency to be drastically increased as compared with the plasma-alone case. Read More

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http://dx.doi.org/10.1016/j.ultsonch.2020.105236DOI Listing

Evaluation of the SNAP® 4Dx® plus test for the detection of Dirofilaria immitis antigen and characterization of exposure to tick-borne pathogens in wild canids in southern Ontario.

Vet Parasitol 2020 Jun 25;283:109176. Epub 2020 Jun 25.

Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, N1G 2W1, Canada.

Population-level surveys for Dirofilaria immitis in wild canids typically rely on identification of the parasite at necropsy. More recently, some studies have employed the use of the SNAP® 4Dx® Plus test. However, since the assay was designed for use with domestic dogs it needs to be validated for use with wild canids for accurate interpretation of results. Read More

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http://dx.doi.org/10.1016/j.vetpar.2020.109176DOI Listing

The evolving landscape of cell surface pattern recognition across plant immune networks.

Curr Opin Plant Biol 2020 Jun 29;56:135-146. Epub 2020 Jun 29.

Department of Biology, University of Washington, Seattle WA 98195, USA; Washington Research Foundation, Seattle, WA 98102, USA. Electronic address:

To recognize diverse threats, plants monitor extracellular molecular patterns and transduce intracellular immune signaling through receptor complexes at the plasma membrane. Pattern recognition occurs through a prototypical network of interacting proteins, comprising A) receptors that recognize inputs associated with a growing number of pest and pathogen classes (bacteria, fungi, oomycetes, caterpillars), B) co-receptor kinases that participate in binding and signaling, and C) cytoplasmic kinases that mediate first stages of immune output. While this framework has been elucidated in reference accessions of model organisms, network components are part of gene families with widespread variation, potentially tuning immunocompetence for specific contexts. Read More

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http://dx.doi.org/10.1016/j.pbi.2020.05.001DOI Listing

The effects of 6 mo of supplementation with probiotics and synbiotics on gut microbiota in the adults with prediabetes: A double blind randomized clinical trial.

Nutrition 2020 May 19;79-80:110854. Epub 2020 May 19.

Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:

Objectives: The evidence of 16S rRNA genes in the gut microbiota distinguished a higher Firmicutes-to-Bacteroidetes ratio in individuals who were obese and had diabetes than in a healthy cohort. So, it seems that the modulation of intestinal microbial ecology by pro-/pre-/synbiotics may contribute to the progression and prevention of metabolic diseases. The aim of this study was to assess the effects of probiotics and synbiotic supplementation on the modification of the intestinal microbiome in adults with prediabetes. Read More

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http://dx.doi.org/10.1016/j.nut.2020.110854DOI Listing

Protein glycation and oxidation inhibitory activity of Centella asiatica phenolics (CAP) in glucose-mediated bovine serum albumin glycoxidation.

Food Chem 2020 Jun 10;332:127302. Epub 2020 Jun 10.

Department of Chemistry, Biochemistry and Physics, Université du Québec à Trois-Rivières (UQTR), Trois-Rivières, Québec G9A, 5H7, Canada. Electronic address:

The study aimed to evaluate the inhibitory effects of Centella asiatica phenolics (CAP) on bovine serum albumin glycoxidation in a BSA-glucose model in vitro. The impact of the phenolic extract on the formation of total fluorescent advanced glycation end products (AGEs) and Amadori adducts were determined. Dityrosine, N-formylkynurenine, kynurenine and protein-carbonyls were quantified as markers of protein oxidation. Read More

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http://dx.doi.org/10.1016/j.foodchem.2020.127302DOI Listing

The prevalence of drug-resistant and virulent Staphylococcus spp. in a municipal wastewater treatment plant and their spread in the environment.

Environ Int 2020 Jun 29;143:105914. Epub 2020 Jun 29.

Department of Engineering of Water Protection and Environmental Microbiology, The Faculty of Geoengineering, University of Warmia and Mazury in Olsztyn, Prawocheńskiego 1 Str., 10-719 Olsztyn, Poland.

Drug-resistant and pathogenic Staphylococcus spp. strains can reach surface waters and air with wastewater evacuated to the environment. These strains increase the environmental pool of genetic determinants conferring antibiotic resistance and virulence, and constitute a health risk for the employees of wastewater treatment plants (WWTP) who come into daily contact with bioaerosols. Read More

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http://dx.doi.org/10.1016/j.envint.2020.105914DOI Listing

Impact of the expression system on the immune responses to self-assembling protein nanoparticles (SAPNs) displaying HIV-1 V1V2 loop.

Nanomedicine 2020 Jun 29:102255. Epub 2020 Jun 29.

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD 20910; Henry M. Jackson Foundation for the Advancement of Military Medicine, 6720A Rockledge Drive, Bethesda, MD 20817. Electronic address:

The V1V2 loop of the Env protein is a major target for HIV-1 vaccine development because in multiple studies antibodies to this region correlated with protection. Although SAPNs expressed in E. coli elicited anti-V1V2 antibodies, the Env protein is heavily glycosylated. Read More

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http://dx.doi.org/10.1016/j.nano.2020.102255DOI Listing

Fluorescence imaging of the ureter in minimally invasive pelvic surgery.

J Minim Invasive Gynecol 2020 Jun 29. Epub 2020 Jun 29.

University of Alabama at Birmingham, 1700 6th Avenue South, UAB Division of Gynecologic Oncology, WIC Room 10250, Birmingham, AL, 35233, USA. Electronic address:

Study Objective: Determine near optimal dose, safety, and efficacy of nerindocianine in pelvic ureter detection with near-infrared fluorescence imaging in women undergoing minimally invasive pelvic surgery with three FDA-cleared imaging systems.

Design: An open label, phase 1/2a study SETTING: University of Alabama - Birmingham PATIENTS: Forty-one female subjects undergoing minimally invasive gynecological surgery.

Interventions: Subjects received a single dose of nerindocianine sodium, starting at 0. Read More

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http://dx.doi.org/10.1016/j.jmig.2020.06.022DOI Listing

Comparison of long-term clinical and radiographic outcomes between alternative-level and all-level fixation unilateral open-door laminoplasty.

Spine J 2020 Jun 29. Epub 2020 Jun 29.

Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University. No.37, Guoxue Road, Wuhou district, Chengdu, 610041, Si chuan, People's Republic of China.

Background Context: Titanium mini-plate has been used in unilateral open-door laminoplasty to maintain the open angle of laminae. Previously, both all-level fixation (C3-C7) and alternative-level (C3, C5, C7) unilateral open-door laminoplasty have been proven to have satisfactory clinical outcomes. However, whether they could achieve similar long-term clinical and radiographic efficacy is still questionable. Read More

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http://dx.doi.org/10.1016/j.spinee.2020.06.018DOI Listing

Characterizations of SARS-CoV-2 mutational profile, spike protein stability and viral transmission.

Infect Genet Evol 2020 Jun 29:104445. Epub 2020 Jun 29.

Human Genetics Unit, Indian Statistical Institute, 203 B T Road, Kolkata 700 108, India. Electronic address:

The recent pandemic of SARS-CoV-2 infection has affected more than 3.0 million people worldwide with more than 200 thousand reported deaths. The SARS-CoV-2 genome has the capability of gaining rapid mutations as the virus spreads. Read More

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http://dx.doi.org/10.1016/j.meegid.2020.104445DOI Listing

Improvement of a disk diffusion method for antibiotic susceptibility testing of anaerobic bacteria. French recommendations revisited for 2020.

Authors:
L Dubreuil

Anaerobe 2020 Jun 29:102213. Epub 2020 Jun 29.

Faculté de Pharmacie, University of Lille, Rue du Professeur Laguesse, BP 59006, Lille cedex, France. Electronic address:

The disk diffusion test is very popular but for anaerobes the main pitfalls arise from the significant variation of diameters for an individual MIC and the weak correlation observed between the MIC's values and diameters zone that generates many major and very major errors.

Aims Of The Study: without any change in the methodology and revisiting only new diameter breakpoints, we try to improve the previous French recommendations and therefore decrease number of errors by introducing recent EUCAST concepts such as ECOFF and ATU Zone.

Method: MIC determination by agar dilution was done on 100 anaerobes against 6 antibiotics. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102213DOI Listing

Predicting severe outcomes in COVID-19.

J Allergy Clin Immunol Pract 2020 Jun 29. Epub 2020 Jun 29.

Scottish Centre for Respiratory Research, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK.

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http://dx.doi.org/10.1016/j.jaip.2020.06.039DOI Listing

The Changes of ADC Value, DCE-MRI Parameters and Their Influence on Neuropsychology in Prostate Cancer Patients after Endocrine Therapy Based on Magnetic Resonance Imaging.

Neurosci Lett 2020 Jun 29:135221. Epub 2020 Jun 29.

Department of Radiology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, 223300, Jiangsu, China. Electronic address:

This study was to explore the changes in apparent diffusion coefficient (ADC) values and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) quantitative parameters before and after endocrine therapy in patients with prostate cancer (PCa), and the effect of endocrine therapy on the neuropsychological cognitive function of patients. By using the IoT technology based on radio frequency identification (RFID), the clinical and imaging data of 80 patients confirmed AP+ PCa pathology were analyzed. Patients included had no history of PCa treatment, and routine magnetic resonance imaging (MRI), diffusion weighted imaging (DWI), and DCE-MRI tests were performed before and after endocrinology and anti-infection therapy to measure the ADC value and DCE-MRI quantitative parameters, volume transport constants (K), rate constants ( K ) and extravascular extracellular space volume fraction (Ve) and serum prostate specific antigen (PSA) levels in PCa areas and non-cancer areas. Read More

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http://dx.doi.org/10.1016/j.neulet.2020.135221DOI Listing

Ochratoxin A induces glomerular injury through activating the ERK/NF-κB signaling pathway.

Food Chem Toxicol 2020 Jun 29:111516. Epub 2020 Jun 29.

College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China; Institute of Nutritional and Metabolic Disorders in Domestic Animals and Fowls, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China. Electronic address:

Ochratoxin A (OTA) was reported to induce proximal tubules nephrotoxicity in humans and animals. However, the toxicity of OTA on glomeruli has rarely been studied. We investigated OTA-induced glomerular injury and the underlying mechanisms. Read More

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http://dx.doi.org/10.1016/j.fct.2020.111516DOI Listing

Tailoring the surface properties and flexibility of starch-based films using oil and waxes recovered from potato chips byproducts.

Int J Biol Macromol 2020 Jun 29. Epub 2020 Jun 29.

LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.

Agrofood byproducts may be exploited as a source of biomolecules suitable for developing bioplastic materials. In this work, the feasibility of using starch, oil, and waxes recovered from potato chips byproducts for films production was studied. The recovered potato starch-rich fraction (RPS) contained an amylopectin/amylose ratio of 2. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.06.231DOI Listing

Sustainable production, biochemical and molecular characterization of thermo-and-solvent stable alkaline serine keratinase from novel Bacillus pumilus ar57 for promising poultry solid waste management.

Int J Biol Macromol 2020 Jun 29. Epub 2020 Jun 29.

Department of Biotechnology, University College of Engineering, Anna University - BIT Campus, Tiruchirappalli, Tamilnadu 620 024, India. Electronic address:

The increasing amount of recalcitrant keratinous wastes generated from the poultry industry poses a serious threat to the environment. Keratinase have gained much attention to convert these wastes into valuable products. Ever since primitive feathers first appeared on dinosaurs, microorganisms have evolved to degrade this most recalcitrant keratin. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.06.219DOI Listing

The reorganization of conformations, stability and aggregation of serum albumin isomers through the interaction of glycopeptide antibiotic teicoplanin: A thermodynamic and spectroscopy study.

Int J Biol Macromol 2020 Jun 29. Epub 2020 Jun 29.

Protein Assembly Laboratory (PAL), JH-Institute of Molecular Medicine, Jamia Hamdard, Hamdard Nagar, New Delhi 110062, India. Electronic address:

The drugs-protein binding study is of growing importance for drug-repurposing against amyloidosis. In this work, we study the binding of teicoplanin (TPN), a glycopeptide antibiotic, with bovine serum albumin (BSA) in its neutral (N), physiological (P) and basic (B) forms, which exist at pH 6, pH 7.4 and pH 9, respectively. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.06.258DOI Listing

Type B Aortic Dissection Complicated by Intimo-intimal Intussusception and Extensive Intimal Denuding: Case Report with Long Term Follow-up.

Ann Vasc Surg 2020 Jun 29. Epub 2020 Jun 29.

University of Maryland School of Medicine, Division of Cardiac Surgery, Department of Surgery, Baltimore, MD.

Objectives: Acute aortic dissection rarely results in circumferential dissections of the aortic intima that may lead to intimo-intimal intussusception (IIS) with complete separation from the aortic wall. Circumferential dissection may then result in distal embolization of the involved intima and media, adding considerable complexity to the management of such cases. Despite the severity of this complication, the natural history of aortic disease following extensive intimal denuding and IIS is not well documented in the literature. Read More

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http://dx.doi.org/10.1016/j.avsg.2020.06.041DOI Listing

High flow nasal cannula in the immediate post-operative period: a systematic review and meta-analysis.

Chest 2020 Jun 29. Epub 2020 Jun 29.

Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada. Electronic address:

Background: Recent studies have demonstrated that high flow nasal cannula (HFNC) prevents intubation in acute hypoxic respiratory failure when compared to conventional oxygen therapy (COT). However, the data examining routine HFNC use in the immediate post-operative period is less clear.

Research Question: Is routine HFNC use superior to COT or non-invasive ventilation (NIV) in preventing intubation in post-operative patients?

Study Design: and Methods: We comprehensively searched databases (MEDLINE, EMBASE, Web of Science) to identify randomized controlled trials (RCTs) that compared the effect of HFNC use to COT or NIV in the immediate post-operative period on reintubation, escalation of respiratory support, hospital mortality, ICU and hospital length of stay, post-operative hypoxemia and treatment complications. Read More

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http://dx.doi.org/10.1016/j.chest.2020.06.038DOI Listing

Early precut versus primary precut sphincterotomy to reduce post-ERCP pancreatitis: randomized controlled trial (with videos) Concise and informative title- Primary precut to prevent post ERCP pancreatitis.

Gastrointest Endosc 2020 Jun 29. Epub 2020 Jun 29.

Senior Professor, Department of Gastroenterology, SMS Medical College and Hospitals, Jaipur, India. Electronic address:

Background And Aims: Precut sphincterotomy, usually performed after prolonged and failed cannulation, is considered as one of the risk factors for post-ERCP pancreatitis (PEP). There are limited studies on primary needle-knife precut for the prevention of PEP. The aim of the study was to assess the safety and efficacy of primary precut. Read More

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http://dx.doi.org/10.1016/j.gie.2020.06.064DOI Listing

Prognostic and Predictive Molecular Biomarkers in Chronic Lymphocytic Leukemia.

J Mol Diagn 2020 Jun 29. Epub 2020 Jun 29.

Department of Pathology Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania. Electronic address:

Chronic lymphocytic leukemia (CLL) is a malignancy of B cells with a variable clinical course. Prognostication is important to place patients into different risk categories for guiding decisions on clinical management, to treat or not to treat. Although a number of clinical, cytogenetic and molecular parameters have been established, in the past decade, a tremendous understanding of molecular lesions has been obtained with the advent of high-throughput sequencing. Read More

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http://dx.doi.org/10.1016/j.jmoldx.2020.06.004DOI Listing

Effective isolation of GALT cells: Insights into the intestine immune response of rainbow trout (Oncorhynchus mykiss) to different bacterin vaccine preparations.

Fish Shellfish Immunol 2020 Jun 29. Epub 2020 Jun 29.

Scottish Fish Immunology Research Centre, School of Biological Sciences, University of Aberdeen, AB24 2TZ, UK. Electronic address:

The teleost gut is a multifunction complex structure that plays a pivotal immunological role in homeostasis and the maintenance of health, in addition to digestion of food and/or nutrient absorption. In vitro examination of the intestine leucocyte repertoire has the potential to aid our understanding of gut immune competence and allows a rapid screen of host-microorganism interactions in different immunological contexts. To explore this possibility, in the present study we investigated the response of isolated gut leucocytes to 4 bacterins of Aeromonas salmonicida, prepared from different strains, combinations and strains grown in different environments, in comparison to a Yersinia ruckeri bacterin for which a commercial/effective oral booster vaccine has been developed. Read More

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http://dx.doi.org/10.1016/j.fsi.2020.06.051DOI Listing

Discovery and Function of B Cell IgD Low (BD) B Cells in Immune Tolerance.

J Mol Biol 2020 Jun 29. Epub 2020 Jun 29.

Versiti Blood Research Institute, Milwaukee, WI, USA; Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI, USA. Electronic address:

It is now appreciated that in addition to their role in humoral immunity B cells also exert regulatory mechanisms that lead to attenuation of inflammatory responses. The concept of B cell regulation became well-recognized when mice deficient in B cells due to genetic disruption were shown to be refractory to recovery from the signs of experimental autoimmune encephalomyelitis (EAE), the mouse model of multiple sclerosis. This seminal study spurred the search for B cell regulatory phenotypes and mechanisms of action. Read More

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http://dx.doi.org/10.1016/j.jmb.2020.06.023DOI Listing
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