1,891,220 results match your criteria B E Journal Of Macroeconomics[Journal]


Xenogeneic mesenchymal stem cell transplantation for mandibular defect regeneration.

Xenotransplantation 2020 Jul 6:e12625. Epub 2020 Jul 6.

Division of Orthodontics, College of Dentistry, The Ohio State University, Columbus, OH, USA.

Background: It is commonly accepted that xenogeneic stem cell transplantation for tissue engineering is faced with host immune rejection. Using a rat critical-size mandibular defect model, this study examined whether the immune rejection can be evaded by diminishing T-cell immunity.

Methods: To examine donor cell survival and host immune reaction, pig bone marrow-derived mesenchymal stem cells (BM-MSCs) were labeled with CM-DiI, loaded onto gelatin sponge (5 × 10 cells/scaffold), and transplanted into 5-mm mandibular defects of immunocompetent and T cell-deficient athymic rats. Read More

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http://dx.doi.org/10.1111/xen.12625DOI Listing

[Management of patients with vestibular schwannoma type IV].

Laryngorhinootologie 2020 Jul 6. Epub 2020 Jul 6.

HNO-Klinik, Klinikum Dortmund, Germany.

Background:  Vestibular schwannomas (VSs) are benign, slow-growing tumors that are classified by the Koos and Hannover grading scales. Despite extensive study, the management of large VS remains controversial.

Patients And Methods:  Between 2003 and 2018, 61 patients with VS grade IV were treated in our institution. Read More

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http://dx.doi.org/10.1055/a-1130-6321DOI Listing

Prediction of Hypoglycemia During Admission of Non-Critically Ill Patients: Results from the MENU Study.

Horm Metab Res 2020 Jul 6. Epub 2020 Jul 6.

Department of Internal Medicine A, Yoseftal Hospital, Eilat, Israel.

The objective of the work was to study admission parameters associated with an increased incidence of hypoglycemia during hospitalization of non-critically ill patients. Included in this cross-sectional study were patients admitted to internal medicine units. The Nutritional Risk Screening 2002 (NRS2002) was used for nutritional screening. Read More

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http://dx.doi.org/10.1055/a-1181-8781DOI Listing

[Surgical Treatment of Lung Cancer: How Has the Introduction of the 8th Edition of the TNM Classification Affected Guideline-Based Therapy?]

Zentralbl Chir 2020 Jul 6. Epub 2020 Jul 6.

Abteilung für Thoraxchirurgie, Universitätsklinikum Regensburg, Regensburg, Deutschland.

Study Aim: The 8th edition of the TNM classification combined with the latest update of the S3-guideline (by AWMF/Scientific Medical Societies in Germany) on prevention, diagnosis, therapy and follow-up of lung cancer led to several changes in staging and treatment of lung cancer. The aim of this study was to identify differences in the distribution of patients due to changes from the 7th to the 8th edition that affected staging. The influence on surgical therapy will be discussed by using the recommendations of the latest S3 guideline. Read More

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http://dx.doi.org/10.1055/a-1164-7058DOI Listing

Impact of Age of Patient and Experience of Surgeon on the Outcome after Kasai Portoenterostomy: Can We Delay the Surgery?

Eur J Pediatr Surg 2020 Jul 6. Epub 2020 Jul 6.

Department of Surgery, The Chinese University of Hong Kong, New Territories, Hong Kong.

Introduction:  Age of patient and experience of biliary atresia (BA) center are well-known factors associated with early jaundice clearance (EJC) after Kasai portoenterostomy (KPE) in infants with BA. This study focused on the impact of age and surgeon factor on the short-term outcome after KPE within a single center.

Materials And Methods:  Fifty-four consecutive infants (18 boys and 36 girls) who underwent KPE from January 2010 to January 2020 were reviewed. Read More

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http://dx.doi.org/10.1055/s-0040-1713934DOI Listing

Melioidosis: A Neglected Cause of Community-Acquired Pneumonia.

Semin Respir Crit Care Med 2020 Aug 6;41(4):496-508. Epub 2020 Jul 6.

Center for Experimental and Molecular Medicine, Amsterdam Infection & Immunity Institute, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Melioidosis, caused by the facultative intracellular gram-negative pathogen , is an emerging cause of community-acquired pneumonia across the tropics. The majority of patients present with pneumonia with or without sepsis, but localized and asymptomatic infection is also well recognized. Recent modeling and epidemiological studies have demonstrated the widespread presence of in otherwise unrecognized regions with a predicted mortality of 90,000 deaths worldwide. Read More

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http://dx.doi.org/10.1055/s-0040-1710570DOI Listing

Analysis of Innate and Adaptive Immunological Characteristics in Patients with IgG4-Related Disease.

Int Arch Allergy Immunol 2020 Jul 6:1-6. Epub 2020 Jul 6.

Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul National University College of Medicine, Seoul, Republic of Korea,

Background: Immunoglobulin G4-related disease (IgG4-RD) is a systemic immunological disorder characterized by fibro-inflammatory conditions; however, the pathobiology of IgG4-RD has not been fully identified.

Objective: This study aimed to analyze systemic differences of innate and adaptive immune cells from healthy controls and patients with IgG4-RD.

Methods: Healthy controls (n = 9) and IgG4-RD patients (n = 7) were recruited with informed consent. Read More

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http://dx.doi.org/10.1159/000508699DOI Listing

Phase III Randomized Study of Induction Chemotherapy Followed by Definitive Radiotherapy + Cetuximab Versus Chemoradiotherapy in Squamous Cell Carcinoma of Head and Neck: The INTERCEPTOR-GONO Study (NCT00999700).

Oncology 2020 Jul 6:1-8. Epub 2020 Jul 6.

Statistic Unit, Genova University, Genova, Italy.

Objectives: Induction chemotherapy followed by cetuximab and RT (IBRT) (Arm A) was compared to cisplatin/RT (CRT) (Arm B) in a randomized phase III study.

Patients And Methods: Naïve patients with stage III-IVa, histologically proven locally advanced head and neck cancer (LASCCHN) were eligible. Arm A (IBRT): 3 TPF induction followed by cetuximab-RT (equivalent daily dose 2 Gy up to 70 Gy); Arm B: 3 cisplatin concurrent with the same RT scheduling. Read More

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http://dx.doi.org/10.1159/000507733DOI Listing

Patient-specific CT calibration based on ion radiography for different detector configurations inH,He andC ion pencil beam scanning.

Phys Med Biol 2020 Jul 6. Epub 2020 Jul 6.

Department of Medical Physics, Ludwig-Maximilians-Universität München Fakultät für Physik, München, Bayern, GERMANY.

The empirical conversion of the treatment planning X-ray Computed Tomography (CT) image to ion stopping power relative to water causes dose calculation inaccuracies in ion beam therapy. A patient-specific calibration of the CT image is enabled by the combination of an ion radiography (iRad) with the forward-projection of the empirically converted CT image along the estimated ion trajectories. This work investigated the patient-specific CT calibration for list-mode and integration-mode detector configurations, with reference to a ground truth ion CT (iCT) image. Read More

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http://dx.doi.org/10.1088/1361-6560/aba319DOI Listing

Does the Inion OTPSabsorbable plating system induce higher foreign-body reaction than titanium implants? An experimental randomized comparative study in rabbits.

Biomed Mater 2020 Jul 6. Epub 2020 Jul 6.

1st Orthopaedic Department, Aristoteleio Panepistemio Thessalonikes Schole Epistemon Ygeias, Thessaloniki, Thessaloniki, GREECE.

Hardware removal after complete fracture healing is a laborious and traumatic procedure that bears the risks of refracture, infection, and soft tissue damage. Absorbable materials for fracture fixation have the advantage of eliminating the need for removal, however, they may stimulate a considerable inflammatory response. For that reason, we compared in a prospective randomized experimental animal model study the incidence of foreign-body reactions between Inion OTPSTM absorbable plate implants, consisting of carbon trimethylene, L-polylactic acid, and D, L-polylactic acid, and conventional titanium plates. Read More

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http://dx.doi.org/10.1088/1748-605X/aba326DOI Listing

Single and repeated low-dose UVB radiation exposures affect the visual system.

J Photochem Photobiol B 2020 Jun 28;209:111941. Epub 2020 Jun 28.

Instituto de Ciências Biológicas (ICB), Universidade Federal do Rio Grande - FURG, Rio Grande, RS, Brazil; Programa de Pós-Graduação em Ciências Fisiológicas, Universidade Federal do Rio Grande - FURG, Rio Grande, RS, Brazil. Electronic address:

The visual system is an important biological indicator of effects induced by ultraviolet (UV) radiation. However, research has extensively investigated the effects of high-dose UV radiation in a single exposure, thus, the differential of this work was to investigate the effects of UVB radiation in low doses in single and repeated exposure. Therefore, we investigated the effects of repeated exposure to environmental UVB doses (0. Read More

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http://dx.doi.org/10.1016/j.jphotobiol.2020.111941DOI Listing

Evaluation of plasma EGFR mutation as an early predictor of response of erlotinib plus bevacizumab treatment in the NEJ026 study.

EBioMedicine 2020 Jul 3;57:102861. Epub 2020 Jul 3.

Division of Pulmonary Medicine, Allergy, and Rheumatology, Department of Internal Medicine, Iwate Medical University School of Medicine, 2-1-1, Idaidori, Yahaba-cho, Shiwa-gun, Iwate 028-3695, Japan. Electronic address:

Background: The NEJ026 Phase 3 study demonstrated that erlotinib and bevacizumab (BE)-treated NSCLC patients with EGFR mutations had significantly better progression-free survival (PFS) than those treated with erlotinib alone (E). This study included a prospective analysis of the relationship between the mutational status of EGFR in plasma circulating tumor DNA (ctDNA) and the efficacy of TKI monotherapy or combination therapy. We describe these results herein. Read More

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http://dx.doi.org/10.1016/j.ebiom.2020.102861DOI Listing

Prognostic nomogram in patients with metastatic adenoid cystic carcinoma of the salivary glands.

Eur J Cancer 2020 Jul 3;136:35-42. Epub 2020 Jul 3.

Head and Neck Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Italy.

Background: Distant metastases in adenoid cystic carcinoma (ACC) are common. There is no consensus on the management of metastatic disease because no therapeutic approach has demonstrated improvement in overall survival (OS) and because of prolonged life expectancy. The aim of this study is to build and validate a prognostic nomogram for metastatic ACC patients. Read More

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http://dx.doi.org/10.1016/j.ejca.2020.05.013DOI Listing

Non-nuke HIV-1 inhibitor shuttled by mesoporous silica nanoparticles effectively slows down HIV-1 replication in infected human cells.

Colloids Surf B Biointerfaces 2020 Jun 26;194:111227. Epub 2020 Jun 26.

Department of Virology, ICMR-National AIDS Research Institute, Pune, 411 026, Maharashtra, India; Savitribai Phule Pune University, Ganeshkhind, Pune 411 007, India. Electronic address:

The objectives of this study were to reduce the cytotoxic effect of nevirapine (NVP) and to enhance its anti-HIV efficacy through mesoporous silica nanoparticles (MSNPs) mediated delivery. MSNPs were synthesized and characterized by various techniques. Confocal microscopy and flow cytometry results exhibited efficient uptake of FITC-conjugated MSNPs in TZM-bl cells. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2020.111227DOI Listing

Treatment of MOG-IgG-associated disorder with rituximab: An international study of 121 patients.

Mult Scler Relat Disord 2020 Jun 2;44:102251. Epub 2020 Jun 2.

Department of Neurology, The Walton Centre NHS Foundation Trust, Liverpool, United Kingdom; Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom; Department of Neurology, The Cleveland Clinic Abu Dhabi, United Arab Emirates. Electronic address:

Objective: To assess the effect of anti-CD20 B-cell depletion with rituximab (RTX) on relapse rates in myelin oligodendrocyte glycoprotein antibody-associated disorder (MOGAD).

Methods: Retrospective review of RTX-treated MOGAD patients from 29 centres in 13 countries. The primary outcome measure was change in relapse rate after starting rituximab (Poisson regression model). Read More

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http://dx.doi.org/10.1016/j.msard.2020.102251DOI Listing

Construction of β-BiO/BiOCO heterojunction photocatalyst for deep understanding the importance of separation efficiency and valence band position.

J Hazard Mater 2020 Jul 3;401:123262. Epub 2020 Jul 3.

College of Science, Hebei University of Science and Technology, Shijiazhuang 050018, China. Electronic address:

Constructing heterojunctions would result in the change of valence band position, which is an important factor determining the oxidative ability of photo-induced holes, has received scant attention. In this paper, β-BiO/BiOCO composites with different ratios were obtained via ionic-liquid-assisted solvothermal and in-situ calcination processes. UV-vis DRS, Mott-Schottky test, and Kelvin probe measurement showed the change of band gaps of β-BiO and BiOCO before and after heterojunction formation. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.123262DOI Listing

Intramedullary implants coated with cubic boron nitride enhance bone fracture healing in a rat model.

J Trace Elem Med Biol 2020 Jun 23;62:126599. Epub 2020 Jun 23.

Atılım University, Department of Manufacturing Engineering, Ankara, Turkey. Electronic address:

Background: Boron nitride is a biocompatible and an osteo-inductive material for orthopedic applications. The aim of this study was to evaluate the effects of two different allotrope boron nitride coated implants, cubic boron nitride and hexagonal boron nitride, on fracture healing.

Methods: In this experimental study, a total of 24 rats were divided into three groups. Read More

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http://dx.doi.org/10.1016/j.jtemb.2020.126599DOI Listing

Parallel ensemble learning of convolutional neural networks and local binary patterns for face recognition.

Comput Methods Programs Biomed 2020 Jun 29;197:105622. Epub 2020 Jun 29.

Beijing Institute of Technology, Zhuhai 519088, China. Electronic address:

Background And Objective: Face recognition success rate is influenced by illumination, expression, posture change, and other factors, which is due to the low generalization ability of a single convolutional neural network. A new face recognition method based on parallel ensemble learning of convolutional neural networks (CNN) and local binary patterns (LBP) is proposed to solve this problem. It also helps to improve the low pedestrian detection rate caused by occlusion. Read More

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http://dx.doi.org/10.1016/j.cmpb.2020.105622DOI Listing

Norcolocynthenins A and B, two cucurbitane 3-nor-Triterpenoids from Citrullus colocynthis and their cytotoxicity.

Bioorg Chem 2020 Jun 25;101:104045. Epub 2020 Jun 25.

The Laboratory of Effective Substances of Jiangxi Genuine Medicinal Materials, College of Life Sciences, Jiangxi Normal University, Nanchang330022, China; The Key Laboratory of Plant Resources and Chemistry of Arid Zone, State Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China. Electronic address:

Two novel cucurbitane 3-nor-triterpenoids, named norcolocynthenins A (1) and B (2), were isolated from the fruits of Citrullus colocynthis. The structures including their absolute configurations were determined by extensive spectroscopic analyses and theoretical calculations. Compound 1 features an unprecedented 5/6/6/5-fused ring system while compound 2 possesses a rare lactone moiety at modified ring A. Read More

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http://dx.doi.org/10.1016/j.bioorg.2020.104045DOI Listing

8-Benzylaminoxanthine scaffold variations for selective ligands acting on adenosine A receptors. Design, synthesis and biological evaluation.

Bioorg Chem 2020 Jun 19;101:104033. Epub 2020 Jun 19.

Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30688 Kraków, Poland. Electronic address:

A library of 34 novel compounds based on a xanthine scaffold was explored in biological studies for interaction with adenosine receptors (ARs). Structural modifications of the xanthine core were introduced in the 8-position (benzylamino and benzyloxy substitution) as well as at N1, N3, and N7 (small alkyl residues), thereby improving affinity and selectivity for the A AR. The compounds were characterized by radioligand binding assays, and our study resulted in the development of the potent A AR ligands including 8-((6-chloro-2-fluoro-3-methoxybenzyl)amino)-1-ethyl-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione (12d; K human AAR: 68. Read More

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http://dx.doi.org/10.1016/j.bioorg.2020.104033DOI Listing

Snowballing transmission of COVID-19 (SARS-CoV-2) through wastewater: Any sustainable preventive measures to curtail the scourge in low-income countries?

Sci Total Environ 2020 Jul 2;742:140680. Epub 2020 Jul 2.

Department of Agricultural Civil Engineering, Kyungpook National University, Daegu, Republic of Korea; Institute of Agricultural Science & Technology, Kyungpook National University, Daegu, Republic of Korea. Electronic address:

In this communication, we proposed sustainable preventive measures that may be adopted by the low-income countries to forestall the potential outbreak and transmission of COVID-19 (coronavirus disease 2019) through wastewater. Most low-income countries have poor sanitation and wastewater management policies, which create potential risks of COVID 19 spread. Hence, the proposed measures include decentralization of wastewater treatment facilities, community-wide monitoring and testing of SARS-CoV-2 in wastewater samples, improved sanitation, developing point-of-use devices for wastewater decontamination, and more focused policy interventions. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.140680DOI Listing

Naphthylisoquinoline alkaloids and their synthetic analogs as potent novel inhibitors against Babesia canis in vitro.

Vet Parasitol 2020 Jun 26;283:109177. Epub 2020 Jun 26.

Department of Epizootiology and Clinic of Infectious Diseases, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, ul. Głęboka 30, 20-612, Lublin, Poland. Electronic address:

Babesia canis is the predominant and clinically relevant canine Babesia species in Europe. Transmitted by vector ticks, the parasite enters red blood cells and induces a severe, potentially fatal hemolytic anemia. Here, we report on the antibabesial activities of three extracts of the West African tropical plant species Triphyophyllum peltatum (Dioncophyllaceae) and Ancistrocladus abbreviatus (Ancistrocladaceae) and of 13 genuine naphthylisoquinoline alkaloids isolated thereof. Read More

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http://dx.doi.org/10.1016/j.vetpar.2020.109177DOI Listing

Toxic effects of heavy metal Cd and Zn on chlorophyll, carotenoid metabolism and photosynthetic function in tobacco leaves revealed by physiological and proteomics analysis.

Ecotoxicol Environ Saf 2020 Jul 3;202:110856. Epub 2020 Jul 3.

Key Laboratory of Saline-alkali Vegetation Ecology Restoration, Ministry of Education, College of Life Sciences, Northeast Forestry University, Harbin, Heilongjiang, China. Electronic address:

To explore the mechanisms underlying the action of the heavy metals Cd and Zn on the photosynthetic function of plant leaves, the effects of 100 μmol L Cd and 200 μmol L Zn stress (the exposure concentrations of Cd and Zn in the culture medium were 2.24 mg kg and 5.36 mg kg) on the chlorophyll and carotenoid contents as well as the photosynthetic function of tobacco leaves (Long Jiang 911) were studied. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2020.110856DOI Listing

Top down proteomic analysis of gingival Crevicular fluid in deciduous, exfoliating and permanent teeth in children.

J Proteomics 2020 Jul 3:103890. Epub 2020 Jul 3.

Laboratorio di Proteomica e Metabonomica-IRCCS Fondazione Santa Lucia, Roma, Italy.

Gingival Crevicular Fluid (GCF), a plasma-derived exudate present in the gingival crevice was collected from deciduous, exfoliating and permanent teeth from 20 children (60 samples) with the aim to characterize and quantify by a mass spectrometry based top-down proteomic approach, the peptide/proteins in the fluid and verify possible variations occurring during the exfoliating process. The results obtained confirmed the presence in GCF of α-Defensins 1-4, Thymosin β4 and Thymosin β10, as described in previous works and revealed the presence of other interesting peptides never described before in GCF such as specific fragments of α-1-antitrypsin, α-1-antichymotrypsin; fragments of Thymosin β4 and Thymosin β10; Fibrinopeptide A and its fragments and Fibrinopeptide B; S100A8 and S100A9, LVV Hemorphin-7 (hemoglobin chain β fragment), as well as some other peptides deriving from α and β subunits of hemoglobin. Statistical analysis evidenced different levels in 5 proteins/peptides in the three groups. Read More

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http://dx.doi.org/10.1016/j.jprot.2020.103890DOI Listing

Evaluation of the Aptima™ HBV Quant Dx assay for semi-quantitative HBV viral load from dried blood spots.

J Clin Virol 2020 Jun 27;129:104524. Epub 2020 Jun 27.

Virology Department, Angers University Hospital, Angers, France; HIFIH Laboratory EA 3859, LUNAM, Angers, France. Electronic address:

Background: The detection and quantification of hepatitis B virus (HBV) DNA from dried blood spots (DBS) is a major tool for chronic hepatitis B management in resource-limited settings. This strategy fits in perfectly with the hepatitis control plan promoted by the World Health Organization. However, few commercial methods are validated for viral load (VL) measurement on DBS. Read More

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http://dx.doi.org/10.1016/j.jcv.2020.104524DOI Listing

The population of oomycetes in a recycled irrigation water system at a horticultural nursery in southern California.

Water Res 2020 Jun 16;183:116050. Epub 2020 Jun 16.

Department of Crop and Soil Science, Oregon State University, Corvallis, OR, 97331, USA; Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR, 97331, USA.

Recapture and recycling of irrigation water is often required to meet enormous water demands at horticultural nurseries. We tested four water types associated with a recycled irrigation system at a commercial container nursery in southern California for presence of oomycete plant pathogens from July 2015 to December 2017. These water types included: the main source of water originating from a reservoir, retention water from an on-site collection pond, irrigation water received by different growing areas within the nursery, and irrigation runoff captured in polyethylene sheet-lined runoff channels. Read More

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http://dx.doi.org/10.1016/j.watres.2020.116050DOI Listing

A family history of SCID and unrevealing WES: An approach to management and guidance of patients.

Clin Immunol 2020 Jul 3:108520. Epub 2020 Jul 3.

Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

Severe Combined Immunodeficiency (SCID) is a genetically heterogeneous group of disorders characterized by severe T cell lymphopenia and defective T and B cell function. Without prompt diagnosis and early intervention, patients with SCID typically die from infection within the first year of life. Advances in molecular genetics have led to rapid and efficient diagnosis of SCID cases, particularly when paired with newborn screening. Read More

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http://dx.doi.org/10.1016/j.clim.2020.108520DOI Listing

Waste of Mytella Falcata shells for removal of a triarylmethane biocide from water: Kinetic, equilibrium, regeneration and thermodynamic studies.

Colloids Surf B Biointerfaces 2020 Jun 30;195:111230. Epub 2020 Jun 30.

Laboratório de Processos (LaPro), Centro de Tecnologia, Universidade Federal de Alagoas, Maceió, AL, Brazil. Electronic address:

Waste of Mytella falcata shell was used as low-cost adsorbent to remove the biocide Basic Green 4 (BG4) from water. Shells were collected form trash nearby the lagoon were Mytella falcata is fished. After clean, dry and crushed, the powder was characterized by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), X-ray powder diffraction (XRD), and X-ray dispersive energy spectroscopy (EDS). Read More

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http://dx.doi.org/10.1016/j.colsurfb.2020.111230DOI Listing

Identification of the Vo domain of V-ATPase in Bombyx mori silkworm.

Int J Biol Macromol 2020 Jul 3. Epub 2020 Jul 3.

State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400715, China; Biological Science Research Center, Southwest University, Chongqing 400715, China; Chongqing Key Laboratory of Sericultural Science, Chongqing Engineering and Technology Research Center for Novel Silk Materials, Southwest University, Chongqing 400715, China. Electronic address:

Vacuolar H-ATPase (V-ATPase) is very important for eukaryotes and consists of a conserved V domain and slightly variable Vo domain. However, the Vo domain has not been systematically identified in the silkworm Bombyx mori. In this study, 11 Vo domain subunit members were identified throughout the genome of B. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.07.003DOI Listing

Efficient production of saffron crocins and picrocrocin in Nicotiana benthamiana using a virus-driven system.

Metab Eng 2020 Jul 3. Epub 2020 Jul 3.

Instituto de Biología Molecular y Celular de Plantas (Consejo Superior de Investigaciones Científicas-Universitat Politècnica de València), 46022, Valencia, Spain. Electronic address:

Crocins and picrocrocin are glycosylated apocarotenoids responsible, respectively, for the color and the unique taste of the saffron spice, known as red gold due to its high price. Several studies have also shown the health-promoting properties of these compounds. However, their high costs hamper the wide use of these metabolites in the pharmaceutical sector. Read More

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http://dx.doi.org/10.1016/j.ymben.2020.06.009DOI Listing

How to suspect transthyretin cardiac amyloidosis during daily clinical practice.

Int J Cardiol 2020 Jul 3. Epub 2020 Jul 3.

Advocate Christ Medical Center, Oak Lawn, IL, USA.

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http://dx.doi.org/10.1016/j.ijcard.2020.06.045DOI Listing

A transcriptional regulator, IscR, of Burkholderia multivorans acts as both repressor and activator for transcription of iron-sulfur cluster-biosynthetic isc operon.

Res Microbiol 2020 Jul 3. Epub 2020 Jul 3.

Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Sendai 980-8577, Japan. Electronic address:

Bacterial iron-sulfur (Fe-S) clusters are essential cofactors for many metabolic pathways, and Fe-S cluster-containing proteins (Fe-S proteins) regulate the expression of various important genes. However, biosynthesis of such clusters has remained unknown in genus Burkholderia. Here, we clarified that B. Read More

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http://dx.doi.org/10.1016/j.resmic.2020.06.005DOI Listing

Effects of 17β-estradiol on early gonadal development and expression of genes implicated in sexual differentiation of a South American teleost, Astyanax altiparanae.

Comp Biochem Physiol B Biochem Mol Biol 2020 Jul 3:110467. Epub 2020 Jul 3.

Reproductive and Molecular Biology Group, Department of Structural and Functional Biology, Institute of Biosciences, São Paulo State University, Botucatu, São Paulo, Brazil. Electronic address:

Gonadal sex differentiation in teleost fish shows greater plasticity as compared to other vertebrates, as it can be influenced by a variety of factors such as exogenous sex steroids. Exogenous estrogens, such as 17β-estradiol (E2), can induce feminization when administered during early embryonic development. However, the mechanisms underlying the E2-induced feminization are not fully understood, especially in Neotropical species. Read More

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http://dx.doi.org/10.1016/j.cbpb.2020.110467DOI Listing

Effects of Queso Blanco cheese containing Bifidobacterium longum KACC 91563 on fecal microbiota, metabolite and serum cytokine in healthy beagle dogs.

Anaerobe 2020 Jul 3:102234. Epub 2020 Jul 3.

College of Veterinary Medicine, Chungbuk National University, Cheongju, 28644, Republic of Korea. Electronic address:

The study describes the effects of administration of Queso Blanco cheese containing Bifidobacterium longum on the fecal microbiota, metabolite and serum cytokine in healthy beagle dogs. Twelve healthy beagle dogs were randomly divided in three groups of four dogs each:a control group, not fed with any cheese, and groups fed with Queso Blanco cheese with B. longum KACC 91563 (QCB) or without B. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102234DOI Listing

SOCIETY FOR VASCULAR SURGERY CLINICAL PRACTICE GUIDELINES FOR THORACIC ENDOVASCULAR ANEURYSM REPAIR (TEVAR).

J Vasc Surg 2020 Jul 3. Epub 2020 Jul 3.

University of Pennsylvania, Philadelphia, PA.

Thoracic aortic diseases, including disease of the descending thoracic aorta (DTA), are significant causes of death in the United States. Open repair of DTA is a physiologically impactful operation with relatively high rates of mortality, paraplegia, and renal failure. Thoracic endovascular aneurysm repair (TEVAR) has revolutionized the treatment of DTA, and has largely supplanted open repair due to lower morbidity and mortality. Read More

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http://dx.doi.org/10.1016/j.jvs.2020.05.076DOI Listing

Role of fear in a predator-prey system with ratio-dependent functional response in deterministic and stochastic environment.

Biosystems 2020 Jul 3:104176. Epub 2020 Jul 3.

Department of Mathematics, Indian Institute of Engineering Science and Technology, Shibpur, B. Garden, Howrah, 711103, India. Electronic address:

In this article, we propose and analyse a predator-prey model where apart from direct predation the prey population is affected by the fear induced from predators. The reproduction of the prey population is reduced as a cost of fear. The predator is assumed to consume the prey according to ratio-dependent functional response and is also involved in intra-specific competition due to limited resources of food. Read More

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http://dx.doi.org/10.1016/j.biosystems.2020.104176DOI Listing

Uncaria tomentosa improves cognition, memory and learning in middle-aged rats.

Exp Gerontol 2020 Jul 3:111016. Epub 2020 Jul 3.

Departamento de Microbiologia e Parasitologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Av. Roraima, 97105-900 Santa Maria, RS, Brazil; Programa de Pós-Graduação em Bioquímica Toxicológica, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Av. Roraima, 97105-900 Santa Maria, RS, Brazil. Electronic address:

Aging accelerates neurodegeneration, while natural and safe neuroprotective agents, such as Uncaria tomentosa, may help to overcome this problem. This study assessed the effects of U. tomentosa extract treatment on the aging process in the brain of Wistar rats. Read More

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http://dx.doi.org/10.1016/j.exger.2020.111016DOI Listing

Assessment of Cone Beam Computed Tomography (CBCT) Referral Reasons and the Impact of CBCT Evaluation on Decision Treatment Planning Procedure in Endodontics.

J Endod 2020 Jul 3. Epub 2020 Jul 3.

Assistant Professor, Department of Endodontics, Dental School, University of Athens, Greece. Electronic address:

Introduction: The aim of the present study was to assess the number of CBCT referral cases from a private Endodontic practice during one year observation period and to investigate if preoperative use of CBCT has an impact on final diagnosis and decision treatment planning.

Methods: The data of the patients attended a private endodontic office in Athens, seeking for endodontic treatment, from Jan 2018 to Dec 2018 were scanned to retrieve all the cases which were further referred for CBCT evaluation. Two qualified (University of Athens) and experienced (more than ten years of daily practicing) endodontists referred the cases for CBCT imaging. Read More

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http://dx.doi.org/10.1016/j.joen.2020.06.043DOI Listing

Studies on the Performance of Molar Porous Root-Analogue Implant by Finite Element Model Simulation and Verification of a Case Report.

J Oral Maxillofac Surg 2020 Jun 14. Epub 2020 Jun 14.

Professor, Department of Oral and Maxillofacial Surgery, School of Stomatology, Xi'an Medical University, Xi'an, China. Electronic address:

Purpose: The aim of this study was to evaluate the effect of porous layer thickness in a 3-dimensionally printed 1-piece molar porous root-analogue implant (RAI) on the biomechanical properties of the peri-implant bone and the clinical efficacy of one such implant in a patient.

Materials And Methods: Three RAIs with different superficial porous layer thicknesses (0.5 mm, 1 mm, and fully porous) were designed and assembled using a mandible model and then solidified to obtain 3 finite elements models, denoted A, B, and C. Read More

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http://dx.doi.org/10.1016/j.joms.2020.06.002DOI Listing

Gene expression changes in response to low temperatures in embryos of the kelp grouper, Epinephelus moara.

Cryobiology 2020 Jul 3. Epub 2020 Jul 3.

Ming Bo Aquatic Co. Ltd., Laizhou, 261400, China.

The kelp grouper Epinephelus moara has high economic value and is popular in fisheries and aquaculture in China. In the previous study, we treated the embryos at 16-22 somite stage at 4 °C, -25.7 °C, -140 °C and -196 °C, and successfully obtained surviving embryos in each group. Read More

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http://dx.doi.org/10.1016/j.cryobiol.2020.05.013DOI Listing

Estimation of Coronavirus Disease 2019 Burden and Potential for International Dissemination of Infection From Iran.

Ann Intern Med 2020 Jul;173(1):74-75

University of Toronto, Toronto, Ontario, Canada (A.R.T., D.F.).

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http://dx.doi.org/10.7326/L20-0593DOI Listing

It's Time to Revise the Uniform Determination of Death Act.

Ann Intern Med 2020 Jul;173(1):75-76

Mitchell Hamline School of Law, Saint Paul, Minnesota (T.P.).

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http://dx.doi.org/10.7326/L20-0257DOI Listing

Tenofovir Alafenamide for HIV Preexposure Prophylaxis.

Ann Intern Med 2020 Jul;173(1):77-78

Gilead Sciences, Foster City, California (D.B., S.M.).

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http://dx.doi.org/10.7326/L20-0300DOI Listing

Immune Checkpoint Inhibitor-Induced Upper Gastrointestinal Tract Inflammation Shows Morphologic Similarities to, but Is Immunologically Distinct From, Gastritis and Celiac Disease.

Arch Pathol Lab Med 2020 Jul 6. Epub 2020 Jul 6.

From the Department of Pathology, Yale University School of Medicine, New Haven, Connecticut.

Context.—: Immune checkpoint inhibitor (CPI) therapies are associated with multi-organ immune-related adverse events. Although colonic mucosal changes have been described, inflammatory changes incited by CPIs in the upper gastrointestinal tract have not been well characterized. Read More

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http://dx.doi.org/10.5858/arpa.2019-0700-OADOI Listing

Heterogeneous Rotational Dynamics of Imidazolium-Based Organic Ionic Plastic Crystals.

J Phys Chem B 2020 Jul 6. Epub 2020 Jul 6.

Organic ionic plastic crystals (OIPCs) are a unique class of materials that undergo orientational and conformational motions while maintaining a long-range ordered lattice structure. OIPCs have attracted attention because the rotational motions were known to accelerate the diffusion of mobile ions such as lithium ions. However, only a small number of combinations of cations and anions lead to OIPCs because the rotational motion may be restricted by both the molecular structure and the crystal class. Read More

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http://dx.doi.org/10.1021/acs.jpcb.0c02433DOI Listing

Associations of multimorbidity and patient-reported experiences of care with conservative management among elderly patients with localized prostate cancer.

Cancer Med 2020 Jul 6. Epub 2020 Jul 6.

West Virginia University School of Pharmacy, Pharmaceutical Systems & Policy, Morgantown, WV, USA.

Background: Many elderly localized prostate cancer patients could benefit from conservative management (CM). This retrospective cohort study examined the associations of patient-reported access to care and multimorbidity on CM use patterns among Medicare Fee-for-Service (FFS) beneficiaries with localized prostate cancer.

Methods: We used linked Surveillance, Epidemiology, and End Results cancer Registry, Medicare Claims, and the Medicare Consumer Assessment of Healthcare Providers and Systems (MCAHPS) survey files. Read More

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http://dx.doi.org/10.1002/cam4.3274DOI Listing

Subclinical anthracycline therapy-related cardiac Dysfunction: an ignored stage B heart failure in an African population.

Cardiovasc J Afr 2020 Jun 24;31:1-5. Epub 2020 Jun 24.

Hatter Institute for Cardiovascular Research in Africa, University of Cape Town, Cape Town, South Africa.

Anthracyclines are potent antineoplastic agents with a proven efficacy in the treatment of many paediatric and adult haematological and solid-organ cancers. Anthracycline therapy-related cardiac dysfunction (ATRCD) is the commonest and most well-studied chemotherapy-induced cardiovascular toxicity. Therefore patients who received anthracycline therapy are considered in stage A heart failure. Read More

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http://dx.doi.org/10.5830/CVJA-2020-013DOI Listing

Pyrrocidine, a molecular off switch for fumonisin biosynthesis.

PLoS Pathog 2020 Jul 6;16(7):e1008595. Epub 2020 Jul 6.

USDA, ARS, US National Poultry Research Center, Toxicology & Mycotoxin Research Unit, Athens, Georgia, United States of America.

Sarocladium zeae is a fungal endophyte of maize and can be found co-inhabiting a single seed with Fusarium verticillioides, a major mycotoxigenic food safety threat. S. zeae produces pyrrocidines A and B that inhibit the growth of F. Read More

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http://dx.doi.org/10.1371/journal.ppat.1008595DOI Listing

Long-term effects on growth of an energy-enhanced parenteral nutrition in preterm newborn: A quasi-experimental study.

PLoS One 2020 6;15(7):e0235540. Epub 2020 Jul 6.

Department of Maternal and Child Health Policlinico Umberto I, University La Sapienza, Rome, Italy.

Aim: To assess the best energy intake in Parenteral Nutrition (PN) for preterm newborns, considering both possible benefits for growth and risk of complications.

Methods: Quasi-experimental study comparing two cohorts of newborns, receiving Energy-Enhanced vs. Standard PN (Cohort A, from 1st January 2015 to 31 January 2016 and Cohort B from 1st February 2016 to 31 March 2017; respectively) after implementation of a change in the PN protocol. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235540PLOS
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