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B E Journal Of Macroeconomics[Journal] Publications | PubFacts

1,778,486 results match your criteria B E Journal Of Macroeconomics[Journal]


The combination of 13N-ammonia and 18F-FDG PET/CT in the identification of metabolic phenotype of primary human brain tumors.

Nuklearmedizin 2019 Apr 17. Epub 2019 Apr 17.

Department of Nuclear Medicine, the First Affiliated Hospital of Sun Yat-Sen University.

Aim: This pilot study made a preliminary attempt to distinguish different metabolic phenotypes of primary human brain tumors with dual tracer N-ammonia and F-FDG.

Methods: 74 patients were included in this study including 12 benign meningiomas (B-MEN), 4 malignant meningiomas (M-MEN), 15 low-grade gliomas (LGG), 32 high-grade gliomas (HGG) and 11 primary central nervous system lymphomas (PCNSL). All patients underwent N-ammonia and F-FDG PET imaging. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0835-5746
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http://dx.doi.org/10.1055/a-0835-5746DOI Listing
April 2019
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NT-proBNP and Echocardiographic Parameters in Liver Cirrhosis - Correlations with Disease Severity.

Med Princ Pract 2019 Apr 16. Epub 2019 Apr 16.

determined. Liver disease severity in patients with cirrhosis was established by Child-Pugh class, MELD score and presence/absence of ascites. Results: Plasma levels of NT-proBNP were significantly higher in cirrhotic patients than in the healthy subjects. Read More

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http://dx.doi.org/10.1159/000499930DOI Listing

Tunable spin-state bistability in a spin crossover molecular complex.

J Phys Condens Matter 2019 Apr 17. Epub 2019 Apr 17.

Department of Physics and Astronomy and Center for Materials Research and Analysis, University of Nebraska- Lincoln, Jorgensen Hall, 855 North 16th Str., NE 68588-0299, Lincoln, 68588-0299, UNITED STATES.

The spin crossover (SCO) transitions at both the surface and over the entire volume of the [Fe{H<sub>2</sub>B(pz)<sub>2</sub>}<sub>2</sub>(bipy)] polycrystalline films on Al2O3 substrates have been studied, where pz = pyrazol-1-yl and bipy = 2,2'-bipyridine. For [Fe{H<sub>2</sub>B(pz)<sub>2</sub>}<sub>2</sub>(bipy)] films of hundreds of nm thick, magnetometry and x-ray absorption spectroscopy measurements show thermal hysteresis in the SCO transition with temperature, although the transition in bulk [Fe{H2B(pz)2}2(bipy)] occurs in a non-hysteretic fashion at 157 K. While the size of the crystallites in those films are similar, the hysteresis becomes more prominent in thinner films, indicating a significant effect of the [Fe{H<sub>2</sub>B(pz)<sub>2</sub>}<sub>2</sub>(bipy)]/Al<sub>2</sub>O<sub>3</sub> interface. Read More

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http://iopscience.iop.org/article/10.1088/1361-648X/ab1a7d
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http://dx.doi.org/10.1088/1361-648X/ab1a7dDOI Listing
April 2019
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2.346 Impact Factor

Dynamic properties of asymmetric double Josephson junction stack with quasiparticle imbalance.

Nanotechnology 2019 Apr 17. Epub 2019 Apr 17.

Institute of Nuclear Physics, M V Lomonosov Moscow State University, 1/2 Leninskie Gory, Moscow 119992, RUSSIA,, Moscow, 119991, RUSSIAN FEDERATION.

We study analytically and numerically the influence of the quasiparticle charge imbalance on the dynamics of the asymmetric Josephson stack formed by two inequivalent junctions: the fast capacitive junction JJ1 and slow non-capacitive junction JJ2. We find, that the switching of the fast junction into resistive state leads to significant increase of the effective critical current of the slow junction. At the same time, the initial switching of the slow junction may either increase or decrease the effective critical current of the fast junction, depending on ratio of their resistances and the value of the capacitance. Read More

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http://dx.doi.org/10.1088/1361-6528/ab1a8eDOI Listing

Observation and modulation of the dissolution of histotripsy-induced bubble clouds with high-frame rate plane wave imaging.

Phys Med Biol 2019 Apr 17. Epub 2019 Apr 17.

Radiology, University of Chicago Medical Center, Chicago, Illinois, UNITED STATES.

Focused ultrasound therapies are a noninvasive means to ablate tissue. Histotripsy utilizes short ultrasound pulses with sufficient tension to nucleate bubble clouds that impart lethal strain to the surrounding tissues. Tracking bubble cloud dissolution between the application of histotripsy pulses is critical to ensure treatment efficacy. Read More

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http://dx.doi.org/10.1088/1361-6560/ab1a64DOI Listing

Ultrasound guided erector spinae plane block for myofascial pain syndrome.

J Clin Anesth 2019 Apr 13;57:121. Epub 2019 Apr 13.

Department of Surgery, Anesthesia and Intensive Care Section "G.B. Morgagni-Pierantoni" Hospital, Forlì, Italy.

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http://dx.doi.org/10.1016/j.jclinane.2019.04.016DOI Listing

Quantitation of vitamin K1 in serum using online SPE-LC-MS/MS and the challenges of working with vitamin K.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Apr 7;1117:41-48. Epub 2019 Apr 7.

Department of Clinical Biochemistry and Immunology, Lillebaelt Hospital, Vejle, Denmark.

Vitamin K1 (phylloquinone) is one of the vitamin Ks. Several studies have previously investigated the role of vitamin K1 status in respect to disease, but without consistent results. Since vitamin K deficiency has been associated with different disease states it is important to develop a biochemical analysis with sufficient sensitivity and a low limit of quantitation (LOQ). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15700232183176
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http://dx.doi.org/10.1016/j.jchromb.2019.04.010DOI Listing
April 2019
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Effect of differently methyl-substituted ionic liquids on Scenedesmus obliquus growth, photosynthesis, respiration, and ultrastructure.

Environ Pollut 2019 Apr 10;250:155-165. Epub 2019 Apr 10.

School of Environmental Science and Engineering, Zhejiang Gongshang University, Hangzhou, Zhejiang, 310018, China. Electronic address:

Concerns have been raised regarding the ecotoxicity of ionic liquids (ILs) owing to their wide usage in numerous fields. Three imidazolium chloride ILs with different numbers of methyl substituents, 1-decyl-imidazolium chloride ([CIM]Cl), 1-decyl-3-methylimidazolium chloride ([CMIM]Cl), and 1-decyl-2,3-dimethylimidazolium chloride ([CDMIM]Cl), were examined to assess their effects on growth, photosynthesis pigments content, chlorophyll fluorescence, photosynthetic and respiration rate, and cellular ultrastructure of Scenedesmus obliquus. The results showed that algal growth was significantly inhibited by ILs treatments. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.04.021DOI Listing

Synthesis and biological evaluation of pyrazolo[3,4-b]pyridine-3-yl pyrimidine derivatives as sGC stimulators for the treatment of pulmonary hypertension.

Eur J Med Chem 2019 Apr 10;173:107-116. Epub 2019 Apr 10.

State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, PR China; Laboratory of Computer-Aided Drug Design & Discovery, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, PR China.

A series of new pyrazolo[3,4-b]pyridin-3-yl pyrimidine derivatives were synthesized and evaluated for the activation of sGC. Compared with riociguat, compound 13a exhibited equivalent in vitro activity on preconstricted rat thoracic aorta rings and in Rat heart Langendorff preparation. Compound 13a also showed acceptable PK profiles, which might become a promising candidate for the treatment of pulmonary hypertension. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.04.014DOI Listing

Further terpenoids from Euphorbia tirucalli.

Fitoterapia 2019 Apr 14. Epub 2019 Apr 14.

BioCIS, Université Paris-Sud, CNRS, Université Paris-Saclay, 5 Rue J.-B. Clément, 92290 Châtenay-Malabry, France. Electronic address:

The phytochemical investigation of Euphorbia tirucalli L. (Euphorbiaceae) yielded four new compounds, including a rare cadalene-type sesquiterpene (tirucadalenone), two tirucallane triterpenoids, euphorol L and euphorol M, with the latter being described as an epimeric mixture, and a euphane triterpene, namely, euphorol N, together with 7 known compounds. Their structures and absolute configurations were elucidated from analysis of 1D (1H, J-modulated C) and 2D NMR (HSQC, HMBC and NOESY), high-resolution mass spectrometry (HRESIMS), optical rotation, and GIAO NMR shift calculation followed by CP3 analysis, along with comparison with literature reports. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.04.001DOI Listing

Cytotoxic effect of aqueous ethanolic extract of Luffa cylindrica leaves on cancer stem cells CD44/24 in breast cancer patients with various molecular sub-types using tissue samples in vitro.

J Ethnopharmacol 2019 Apr 14:111877. Epub 2019 Apr 14.

Medical Research Department, National Institute of Occupational Safety and Health, Egypt. Electronic address:

Ethnopharmacological Relevance: Luffa cylindrica (L.) M.Roem is a climbing plant its parts have been used as traditional medicine for the treatment of different types of diseases including diarrhea, inflammation, cancer and viral infections. Read More

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http://dx.doi.org/10.1016/j.jep.2019.111877DOI Listing

Improved Lovastatin Production by Inhibiting (+)-Geodin Biosynthesis in Aspergillus terreus.

N Biotechnol 2019 Apr 14. Epub 2019 Apr 14.

The University of Sydney, School of Chemical and Biomolecular Engineering, Australia.

Lovastatin is widely prescribed to reduce elevated levels of cholesterol and prevent heart-related diseases. Cultivation of Aspergillus terreus (ATCC 20542) with carbohydrates or low-value feedstocks such as glycerol produces lovastatin as a secondary metabolite and (+)-geodin as a by-product. An A. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18716784183167
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http://dx.doi.org/10.1016/j.nbt.2019.04.003DOI Listing
April 2019
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Clinical, immunologic, and molecular spectrum of patients with LPS-responsive beige-like anchor protein (LRBA) deficiency: a systematic review.

J Allergy Clin Immunol Pract 2019 Apr 14. Epub 2019 Apr 14.

Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran. Electronic address:

Background: LPS-responsive beige-like anchor protein (LRBA) deficiency is a primary immunodeficiency and immune dysregulation syndrome caused by biallelic mutations in the LRBA gene. These mutations usually abrogate the protein expression of LRBA, leading to a broad spectrum of clinical phenotypes including autoimmunity, chronic diarrhea, hypogammaglobulinemia and recurrent infections.

Objective: Our aim was to systematically collect all studies reporting on the clinical manifestations, molecular and laboratory findings, and management of patients with LRBA deficiency. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.04.011DOI Listing

Poisoning associated with the use of mushrooms: A review of the global pattern and main characteristics.

Food Chem Toxicol 2019 Apr 14. Epub 2019 Apr 14.

Laboratory of Toxicology, University of Crete, Voutes, Heraklion, Crete, 71003, Greece.

Worldwide, special attention has been paid to wild mushrooms-induced poisoning. This review article provides a report on the global pattern and characteristics of mushroom poisoning and identifies the magnitude of mortality induced by mushroom poisoning. In this work, reasons underlying mushrooms-induced poisoning, and contamination of edible mushrooms by heavy metals and radionuclides, are provided. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02786915193021
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http://dx.doi.org/10.1016/j.fct.2019.04.016DOI Listing
April 2019
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Sex-specific differences in adult cognition and neuroplasticity following repeated combinatory stress and TrkB receptor antagonism in adolescence.

Horm Behav 2019 Apr 14. Epub 2019 Apr 14.

Behavioral Neuroscience Group, School of Psychology, University of Ottawa, 136 Jean-Jacques Lussier, Ottawa, ON, Canada. Electronic address:

Evidence supports brain-derived neurotrophic factor (BDNF) and its primary receptor tyrosine-related kinase B (TrkB) as targets in the treatment of mood disorders. This study characterized the impact of a 10-day combinatory stress paradigm (alternating days of restraint stress and forced swim) and administration of the selective TrkB antagonist ANA-12 (0.5 mg/kg, i. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.04.006DOI Listing

Fractional turnover of apolipoprotein(a) and apolipoprotein B-100 within plasma lipoprotein(a) particles in statin-treated patients with elevated and normal Lp(a) concentration.

Metabolism 2019 Apr 14. Epub 2019 Apr 14.

School of Medicine, University of Western Australia, Perth, Australia; Lipid Disorders Clinic, Department of Cardiology, Royal Perth Hospital, Australia. Electronic address:

Context: Lipoprotein(a) [Lp(a)] is a highly atherogenic lipoprotein characterized by apolipoprotein(a) [apo(a)] covalently bounded to apoB-100 (apoB). However, the metabolism of apo(a) and apoB within plasma Lp(a) particles in patients on statins remains unclear.

Methods: The kinetics of Lp(a)-apo(a) and Lp(a)-apoB were determined in 20 patients with elevated Lp(a) (≥0. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.04.010DOI Listing

Serological and molecular evidence of Bartonella henselae in cats from Luanda city, Angola.

Acta Trop 2019 Apr 14. Epub 2019 Apr 14.

Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Oporto, Portugal; EpiUnit, Epidemiology Research Unit, Institute of Public Health of the University of Porto, Portugal; Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Oporto, Portugal. Electronic address:

A total of 100 domestic cats from Luanda (Angola) were tested for the presence of antibodies against Bartonella henselae and spotted fever group of Rickettsia (SFGR) using indirect immunofluorescence assay (IFA). Molecular screening targeting the riboflavin synthase (ribC) gene for Bartonella and outer membrane protein B (ompB) gene for Rickettsia, using conventional PCR and sequencing was also performed in cat´s blood samples. Sixty-six percent of the cats from Luanda had IgG antibodies against Bartonella species but none of them had antibodies against SFGR. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.04.012DOI Listing

Genomic Sequences from Papua New Guinea: Lack of Genetic Connectivity with Northern Australian or East Timorese Genomes, and New Recombination Findings.

Plant Dis 2019 Apr 16:PDIS09181666RE. Epub 2019 Apr 16.

2 UWA Institute of Agriculture, Faculty of Science, The University of Western Australia, Crawley, WA, Australia.

(ZYMV) isolates were obtained in Papua New Guinea (PNG) from cucumber () or pumpkin ( spp.) plants showing mosaic symptoms growing at Kongop in the Mount Hagen District, Western Highlands Province, or Zage in the Goroka District, Eastern Highlands Province. The samples were blotted onto FTA cards, which were sent to Australia, where they were subjected to high-throughput sequencing. Read More

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http://dx.doi.org/10.1094/PDIS-09-18-1666-REDOI Listing

Boscalid Resistance in : Distribution, Effect on Field Efficacy, and Molecular Characterization.

Plant Dis 2019 Apr 17:PDIS09181555RE. Epub 2019 Apr 17.

1 Department of Plant, Soil, and Microbial Sciences, Michigan State University, East Lansing, MI 48824.

Cherry leaf spot (CLS), caused by the fungus , is a major disease of tart cherry ( L.) trees, leading to early defoliation that results in uneven ripening and poor fruit quality in the current season, reduced fruit set in the following season, and increased potential for winter injury and tree death. Pristine (BASF Corporation, Research Triangle Park, NC), a commonly used fungicide for CLS management in Michigan, is a premix of boscalid, a succinate dehydrogenase inhibitor, and pyraclostrobin, a quinone outside inhibitor. Read More

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http://dx.doi.org/10.1094/PDIS-09-18-1555-REDOI Listing

Expanding Knowledge of the Host Range of and Host Plant Preference of MEAM1.

Plant Dis 2019 Apr 17:PDIS11181941RE. Epub 2019 Apr 17.

2 United States Department of Agriculture-Agricultural Research Service, Salinas, CA, U.S.A.

The crinivirus (ToCV) is often found infecting tomato crops in Brazil, with variable incidence, but associated with prevalence of its primary vector, MEAM1. ToCV control is difficult because there are no resistant commercial tomato varieties or hybrids available and chemical spray for control of the whitefly vector has not been effective. The present study evaluated the partial host range of a Brazilian isolate of ToCV and the preference of MEAM1 for oviposition on those species identified as susceptible to the virus. Read More

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https://apsjournals.apsnet.org/doi/10.1094/PDIS-11-18-1941-R
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http://dx.doi.org/10.1094/PDIS-11-18-1941-REDOI Listing
April 2019
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Time-restricted release of multiple neurotrophic factors promotes axonal regeneration and functional recovery after peripheral nerve injury.

FASEB J 2019 Apr 17:fj201802065RR. Epub 2019 Apr 17.

Department of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.

Delivery of multiple neurotrophic factors (NTFs), especially with time-restricted release kinetics, holds great potential for nerve repair. In this study, we utilized the tetracycline-regulatable Tet-On 3G system to control the expression of c-Jun, which is a common regulator of multiple NTFs in Schwann cells (SCs). , Tet-On/c-Jun-modified SCs showed a tightly controllable secretion of multiple NTFs, including glial cell line-derived NTF, nerve growth factor, brain-derived NTF, and artemin, by the addition or removal of doxycycline (Dox). Read More

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https://www.fasebj.org/doi/10.1096/fj.201802065RR
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http://dx.doi.org/10.1096/fj.201802065RRDOI Listing
April 2019
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Evolutionary Trajectories for the Functional Diversification of Anthracycline Methyltransferases.

ACS Chem Biol 2019 Apr 17. Epub 2019 Apr 17.

Microbial natural products are an important source of chemical entities for drug discovery. Recent advances in understanding the biosynthesis of secondary metabolites has revealed how this rich chemical diversity is generated through functional differentiation of biosynthetic enzymes. For instance, investigations into anthracycline anti-cancer agents have uncovered distinct S-adenosyl methionine (SAM) - dependent proteins: DnrK is a 4-O-methyltransferase involved in daunorubicin biosynthesis, whereas RdmB (52% sequence identity) from the rhodomycin pathway catalyzes 10-hydroxylation. Read More

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http://pubs.acs.org/doi/10.1021/acschembio.9b00238
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http://dx.doi.org/10.1021/acschembio.9b00238DOI Listing
April 2019
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Tisagenlecleucel in Diffuse Large B-Cell Lymphoma. Reply.

N Engl J Med 2019 Apr;380(16):1586

University of Pennsylvania, Philadelphia, PA

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http://dx.doi.org/10.1056/NEJMc1901464DOI Listing

Tisagenlecleucel in Diffuse Large B-Cell Lymphoma.

N Engl J Med 2019 Apr;380(16):1585-1586

Rocket Pharmaceuticals, New York, NY

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http://dx.doi.org/10.1056/NEJMc1901464DOI Listing

Tisagenlecleucel in Diffuse Large B-Cell Lymphoma.

N Engl J Med 2019 Apr;380(16):1585

McGill University, Montreal, QC, Canada

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http://dx.doi.org/10.1056/NEJMc1901464DOI Listing

Effect of Anti-CD4 Antibody UB-421 on HIV-1 Rebound after Treatment Interruption.

N Engl J Med 2019 Apr;380(16):1535-1545

From United Biomedical, Hauppauge, NY (C.-Y.W., B.-S.K., C.L.F., F.W.-S.); United Biomedical Asia (C.-Y.W., S.L.) and United BioPharma (C.-Y.W., B.-S.K., H.-W.S., C.-Y.L., F.-C.T., A.L., F.-H.Y., C.-H.L., W.T., M.-J.L.), Hsinchu, Taipei Veterans General Hospital, Taipei (W.-W.W., H.-Y.L.), and Kaohsiung Veterans General Hospital (H.-C.T.) and Kaohsiung Medical University Hospital (Y.-H.C.), Kaohsiung - all in Taiwan; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (J.B., K.E.C., T.-W.C.); and the California Department of Public Health, Richmond (C.V.H.).

Background: Administration of a single broadly neutralizing human immunodeficiency virus (HIV)-specific antibody to HIV-infected persons leads to the development of antibody-resistant virus in the absence of antiretroviral therapy (ART). It is possible that monotherapy with UB-421, an antibody that blocks the virus-binding site on human CD4+ T cells, could induce sustained virologic suppression without induction of resistance in HIV-infected persons after analytic treatment interruption.

Methods: We conducted a nonrandomized, open-label, phase 2 clinical study evaluating the safety, pharmacokinetics, and antiviral activity of UB-421 monotherapy in HIV-infected persons undergoing analytic treatment interruption. Read More

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http://www.nejm.org/doi/10.1056/NEJMoa1802264
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http://dx.doi.org/10.1056/NEJMoa1802264DOI Listing
April 2019
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Lentiviral Gene Therapy Combined with Low-Dose Busulfan in Infants with SCID-X1.

N Engl J Med 2019 Apr;380(16):1525-1534

From the Departments of Bone Marrow Transplantation and Cellular Therapy (E.M., B.T., W.J., S.G.), Hematology (S.Z., Z.M., J.C., J.D., X.T., B.Y.R., M.J.W., B.P.S.), Therapeutics Production and Quality (T.L., M.M.M.), Immunology (H.A., B.Y.), Pharmaceutical Sciences (S.J.C.), Biostatistics (G.K., C.L.), and Infectious Diseases (G.M.), St. Jude Children's Research Hospital, Memphis, TN; the Allergy and Clinical Immunology Division, Hospital Nacional Edgardo Rebagliati Martins, Lima, Peru (J.C.A.B.); the Department of Pediatrics, Allergy-Immunology Division, Children's Hospital Los Angeles, Los Angeles (J.A.C.), and the Department of Pediatrics, Division of Pediatric Allergy-Immunology-Bone Marrow Transplantation, University of California, San Francisco (UCSF) Benioff Children's Hospital, San Francisco (J.R.L.-B., J.M.P., M.J.C.) - both in California; the Department of Pediatrics, Pediatric Allergy and Immunology, University of New Mexico, Albuquerque (E.D.); University of Oklahoma Health Sciences Center, Tulsa (J.T.L.); Departamento de Pediatria da Universidade de Taubaté, Conselho Nacional de Medicina, São Paulo (A.C.M.A.); Copperfield Childcare, Claremont, South Africa (H.W.); and the Genetic Immunotherapy Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (S.S.D.R., H.L.M.).

Background: Allogeneic hematopoietic stem-cell transplantation for X-linked severe combined immunodeficiency (SCID-X1) often fails to reconstitute immunity associated with T cells, B cells, and natural killer (NK) cells when matched sibling donors are unavailable unless high-dose chemotherapy is given. In previous studies, autologous gene therapy with γ-retroviral vectors failed to reconstitute B-cell and NK-cell immunity and was complicated by vector-related leukemia.

Methods: We performed a dual-center, phase 1-2 safety and efficacy study of a lentiviral vector to transfer complementary DNA to bone marrow stem cells after low-exposure, targeted busulfan conditioning in eight infants with newly diagnosed SCID-X1. Read More

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http://dx.doi.org/10.1056/NEJMoa1815408DOI Listing

Enhancing Retinal Endothelial Glycolysis by Inhibiting UCP2 Promotes Physiologic Retinal Vascular Development in a Model of Retinopathy of Prematurity.

Invest Ophthalmol Vis Sci 2019 Apr;60(5):1604-1613

The John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, United States.

Purpose: We address the hypothesis that uncoupling protein 2 (UCP2), a cellular glucose regulator, delays physiologic retinal vascular development (PRVD) by interfering with glucose uptake through glucose transporter 1 (Glut1).

Methods: In the rat 50/10 oxygen-induced retinopathy (OIR) model, retinal Glut1 and UCP2 were measured and compared to room air (RA)-raised pups at postnatal day 14 (p14). Pups in OIR and RA received intraperitoneal genipin, an UCP2 inhibitor, or control every other day from p3 until p13. Read More

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http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.1
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http://dx.doi.org/10.1167/iovs.19-26553DOI Listing
April 2019
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Relationships of Salinity, Relative Humidity, Mud Flat Fiddler Crabs, Ants, and Sea Ox-Eye Daisy With Ixodid Distribution and Egg Survival on the South Texas Coastal Plains.

Environ Entomol 2019 Apr 17. Epub 2019 Apr 17.

USDA-ARS, Knipling-Bushland U.S. Livestock Insects Research Laboratory, Kerrville, TX.

The South Texas coastal plains are mostly dominated by mesquite-thorn scrub from the Mexican border to cattle ranches extending north from Willacy Co. A wildlife corridor on the plains, composed of natural habitat, supports hosts of many ixodid species. Occasional wind (not lunar) tides and infrequent storm surges inundate coastal plain areas with hypersaline water from the Lower Laguna Madre, creating large areas of saline soil. Read More

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http://dx.doi.org/10.1093/ee/nvz034DOI Listing

Evolutionary history of burrowing asps (Lamprophiidae: Atractaspidinae) with emphasis on fang evolution and prey selection.

PLoS One 2019 17;14(4):e0214889. Epub 2019 Apr 17.

Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas, United States of America.

Atractaspidines are poorly studied, fossorial snakes that are found throughout Africa and western Asia, including the Middle East. We employed concatenated gene-tree analyses and divergence dating approaches to investigate evolutionary relationships and biogeographic patterns of atractaspidines with a multi-locus data set consisting of three mitochondrial (16S, cyt b, and ND4) and two nuclear genes (c-mos and RAG1). We sampled 91 individuals from both atractaspidine genera (Atractaspis and Homoroselaps). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214889PLOS
April 2019
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Critical role of miR-10b in B-RafV600E dependent anchorage independent growth and invasion of melanoma cells.

PLoS One 2019 17;14(4):e0204387. Epub 2019 Apr 17.

Department of Cancer Biology, College of Medicine and Life Sciences, University of Toledo, Health Science Campus, Toledo, OH, United States of America.

Recent high-throughput-sequencing of cancer genomes has identified oncogenic mutations in the B-Raf genetic locus as one of the critical events in melanomagenesis. B-Raf encodes a serine/threonine kinase that regulates the MAPK/ERK kinase (MEK) and extracellular signal-regulated kinase (ERK) protein kinase cascade. In normal cells, the activity of B-Raf is tightly regulated and is required for cell growth and survival. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204387PLOS

Factors influencing engagement in premarital sex among Vietnamese young adults: a qualitative study.

Int J Adolesc Med Health 2019 Apr 17. Epub 2019 Apr 17.

Bournemouth University, Faculty of Health and Social Sciences, Bournemouth House, Bournemouth, BH21 3UJ, UK.

Background With the rising trend of sexual engagement among Vietnamese young adults in recent years, concerns were raised over the issue of premarital sex and its potential health consequences. In order to prevent such consequences and further promote health, an in-depth understanding of factors influencing young people to have premarital sex would be valuable. Objective To generate a grounded theory explaining factors influencing engagement in premarital sex among Vietnamese young adults. Read More

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http://dx.doi.org/10.1515/ijamh-2018-0201DOI Listing

The ellagitannin trimer rugosin G inhibits recombinant human histidine decarboxylase.

Biosci Biotechnol Biochem 2019 Apr 17:1-4. Epub 2019 Apr 17.

e Department of Food Science and Nutrition , Nara Women's University , Kitauoyanishi-machi, Nara , Japan.

Rugosin G, an ellagitannin trimer, was isolated from the water-soluble fraction of red rose petals, and its inhibitory activity against recombinant human histidine decarboxylase was investigated. Rugosin G showed potent inhibition compared to ellagitannin monomers and a dimer with macrocyclic structure (oenothein B), suggesting the potent inhibition of rugosin G was attributed to its linear oligomeric conformation. Abbreviations: HDC, histidine decarboxylase; Me2CO, acetone; EtOAc, ethyl acetate. Read More

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http://dx.doi.org/10.1080/09168451.2019.1606695DOI Listing

Evolution of Surgical Treatment of Carotid Artery Stenosis: a single centre observational study.

Acta Chir Belg 2019 Apr 17:1-28. Epub 2019 Apr 17.

a Department of Thoracic and Vascular Surgery , Ghent University Hospital , Ghent , Belgium.

Background: In 2009 and 2011 respectively ESVS and AHA/ASA guidelines recommended to operate patients with a symptomatic carotid artery stenosis within 14 days. This study aimed primarily to determine if an academic hospital has implemented these international guidelines about indication and timing of surgical treatment of carotid stenosis. Secondary, the influence of referral from another hospital on time from symptoms to surgery and the influence of time between neurological event and surgery on 30-day complication rate was studied. Read More

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April 2019
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DNA Damage and Cytokine Production in Non-Target Irradiated Lymphocytes.

Radiat Res 2019 Apr 17. Epub 2019 Apr 17.

a   Radiation and Environmental Science Centre, FOCAS Institute, Technological University Dublin, Dublin 8, Ireland.

In advanced radiotherapy, treatment of the tumor with high-intensity modulated fields is balanced with normal tissue sparing. However, the non-target dose delivered to surrounding healthy tissue within the irradiated volume is a potential cause for concern. Whether the effects observed are caused after exposure to out-of-field radiation or bystander effects through neighboring irradiated cells is not fully understood. Read More

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http://dx.doi.org/10.1667/RR15165.1DOI Listing

A bipartite begomovirus infecting (family ) in the Dominican Republic represents a distinct phylogenetic lineage and has a high degree of host specificity.

Phytopathology 2019 Apr 17. Epub 2019 Apr 17.

University of California, Davis, Department of Plant Pathology , 1 Shields Ave , Davis, California, United States , 95616 ;

plants in and around agricultural fields in the Azua Valley of the southeastern Dominican Republic often show striking golden mosaic symptoms. Leaf samples from plants showing these symptoms were collected in 2012 and 2013, and PCR tests with degenerate primers revealed begomovirus DNA-A and DNA-B components. The complete sequences of the DNA-A and DNA-B components of four isolates show high degree of sequence identity (>96%), and a genome organization typical of New World (NW) bipartite begomoviruses. Read More

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http://dx.doi.org/10.1094/PHYTO-02-19-0061-RDOI Listing

Diagnostic Decisions in Child Language Assessment: Findings From a Case Review Assessment Task.

Lang Speech Hear Serv Sch 2019 Apr 17:1-14. Epub 2019 Apr 17.

Department of Communicative Disorders and Sciences, University at Buffalo, NY.

Purpose The current study used a case review diagnostic assessment task to examine the diagnostic decisions speech-language pathologists (SLPs) working in the United States made after reviewing child language cases. Method Fourteen SLPs were given 5 case studies that presented either congruent or incongruent results between standardized testing and informal measures. After reviewing the assessment data, SLPs were asked to make a diagnostic decision. Read More

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http://pubs.asha.org/doi/10.1044/2019_LSHSS-18-0044
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http://dx.doi.org/10.1044/2019_LSHSS-18-0044DOI Listing
April 2019
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Psychometric validation of Anti-Clot Treatment Scale and Treatment Satisfaction Questionnaire for Medication version II in Japanese patients with atrial fibrillation.

J Med Econ 2019 Apr 17. Epub 2019 Apr 17.

i Modus Outcomes Ltd , Letchworth Garden City , UK.

Aims: The Anti-Clot Treatment Scale (ACTS) and Treatment Satisfaction Questionnaire for Medication version II (TSQM-II) are validated treatment satisfaction patient-reported outcome (PRO) instruments. The ACTS includes two domains: Burdens and Benefits; the TSQM-II includes four: Effectiveness, Side Effects, Convenience, and Global Satisfaction. Japanese-language versions of the ACTS and TSQM-II have been developed and linguistically validated. Read More

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http://dx.doi.org/10.1080/13696998.2019.1609003DOI Listing

Tissue lipocalin-2 in psoriasis: Is it a marker of metabolic disturbance or a possible marker of therapeutic efficacy after narrow band ultraviolet B?

J Dermatolog Treat 2019 Apr 17:1-20. Epub 2019 Apr 17.

a Dermatology Department, Faculty of Medicine , Cairo University , Egypt.

Background: Lipocalin-2 (LCN2) is an adipokine related to insulin resistance and metabolic syndrome (MetS) in addition to its role in innate immunity and apoptosis.

Objective: To estimate LCN2 tissue levels (lesional and non-lesional) in psoriasis. To assess the metabolic status of patients and to detect any possible associations between LCN2 and MetS. Read More

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https://www.tandfonline.com/doi/full/10.1080/09546634.2019.1
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http://dx.doi.org/10.1080/09546634.2019.1605141DOI Listing
April 2019
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UNBS5162 as a novel naphthalimide holds efficacy in human gastric carcinoma cell behaviors mediated by AKT/ERK signaling pathway.

Drug Dev Ind Pharm 2019 Apr 17:1-17. Epub 2019 Apr 17.

b Department of medical records management , the Second Affiliated Hospital of Mudanjiang Medical University , Mudanjiang , Heilongjiang , 157000 , P.R. China.

Purpose: Studies have determined that UNBS5162, recognized as a new naphthalimide, holds inhibitory effects in prostate and breast tumors, however its functional implication on gastric carcinoma is currently undetermined. Based on this, this study designed to assess the functional role of it on human gastric carcinoma and underlying mechanism of action.

Methods: Cell Counting Kit-8 (CCK-8) assay, transwell assay, and flow cytometry were used to assess capabilities of SGC-7901 cell proliferation, invasion/migration, and apoptosis, respectively. Read More

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http://dx.doi.org/10.1080/03639045.2019.1607870DOI Listing

Dead Sea Climatotherapy versus topical steroid treatment for Atopic Dermatitis children: long-term follow-up study.

J Dermatolog Treat 2019 Apr 17:1-19. Epub 2019 Apr 17.

c Dead Sea & Arava Science Center , Israel.

The aim of this study was to compare long-term results of 4 weeks Dead Sea Climatotherapy at the Deutsches Medizinisches Zentrum, Israel to those obtained by classical topical treatment for moderate-to-severe Atopic Dermatitis. Seventy-two children from the Czech Republic were divided into three groups of twenty-four and treated during 3 periods (March 2014, October 2014 and March 2015) with gradually increasing sun exposure during 28 consecutive days. Forty-four children were treated with steroid creams at the Department of Dermatovenereology, Third Faculty of Medicine, Charles University and University Hospital of Kralovske Vinohrady, Prague, Czech Republic. Read More

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http://dx.doi.org/10.1080/09546634.2019.1605138DOI Listing

Activation of K7 channels with the anticonvulsant retigabine alleviates neuropathic pain behaviour in the streptozotocin rat model of diabetic neuropathy.

J Drug Target 2019 Apr 17:1-25. Epub 2019 Apr 17.

b Medical Physics & Biomedical Engineering, University College London , Gower, Street , London , UK.

Diabetic peripheral neuropathy (DPN) is the most incapacitating complication of diabetes mellitus. Up to 50% of patients with DPN develop peripheral neuropathic pain (PNP). The underlying ionic and molecular mechanisms of diabetic PNP (DPNP) are poorly understood. Read More

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http://dx.doi.org/10.1080/1061186X.2019.1608552DOI Listing

TIPE2 as a potential therapeutic target in chronic viral hepatitis.

Expert Opin Ther Targets 2019 Apr 17. Epub 2019 Apr 17.

a Department of Hepatology , Qilu Hospital of Shandong University , Jinan , China.

Introduction: Tumor necrosis factor-α-induced protein-8 like-2 (TIPE2) is a novel negative regulator of innate and adaptive immune responses by binding to caspase-8. The binding of TIPE2 and caspase-8 can inhibit the activity of activating protein-1(AP-1) and nuclear factor-κB (NF-κB), ultimately promoting Fas-induced apoptosis in immune cells. Therefore, TIPE2-caspase-8-NF-κB signaling might serve as a biomarker and a potential target for therapeutic intervention. Read More

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http://dx.doi.org/10.1080/14728222.2019.1608948DOI Listing

LncRNA NKILA inhibits retinoblastoma by downregulating lncRNA XIST.

Curr Eye Res 2019 Apr 17. Epub 2019 Apr 17.

a Department of Ophthalmology , China-Japan Union Hospital of Jilin University , Changchun , Jilin , 130033 , PR. China.

Purpose: Although retinoblastoma is rare but can be deadly in some severe cases. To find novel therapeutic targets for retinoblastoma, we explored the potential role of lncRNA NKILA in retinoblastoma.

Results: We found that, comparing to healthy controls, NKILA was downregulated, while lncRNA XIST was upregulated in plasma of retinoblastoma patients and they were inversely correlated. Read More

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http://dx.doi.org/10.1080/02713683.2019.1606253DOI Listing

Chronic Tyrosine Kinase Inhibitor (TKI) use in metastatic Renal Cell Carcinoma (mRCC): can this lead to the adverse effect of hypogonadism?

Expert Rev Anticancer Ther 2019 Apr 17. Epub 2019 Apr 17.

g Queen Elizabeth Hospital Birmingham , Birmingham , UK.

Introduction: Patients with metastatic renal cell carcinoma (mRCC) are commonly treated with tyrosine kinase inhibitors (TKIs). An adverse effect frequently suffered by patients is lethargy, which often leads to dose reduction or drug cessation. We aimed to assess whether hypogonadism is related to treatment with TKIs. Read More

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https://www.tandfonline.com/doi/full/10.1080/14737140.2019.1
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http://dx.doi.org/10.1080/14737140.2019.1609355DOI Listing
April 2019
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Motorcycle helmet visor-related facial injury and its potential mechanism of injury: Evidence-based case study.

Traffic Inj Prev 2019 Apr 17:1-4. Epub 2019 Apr 17.

b Monash University Accident Research Centre (MUARC), Monash University , Victoria , Australia.

Objectives: We encountered an unusual facial laceration wound in relation to motorcycle helmet visor use during our clinical practice. We aimed to assess the prevalence of this unusual facial injury among motorcyclists who sustained facial injuries in selected hospitals and to determine the possible mechanism involved.

Methods: We used our prospective cross-sectional substudy involving injured motorcyclists presenting at major trauma hospitals in Southern Klang Valley, Malaysia, between March 2010 and March 2011. Read More

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http://dx.doi.org/10.1080/15389588.2018.1557640DOI Listing

Influence of Axial Length on Parafoveal and Peripapillary Metrics from Swept Source Optical Coherence Tomography Angiography.

Curr Eye Res 2019 Apr 17. Epub 2019 Apr 17.

a Department of Ophthalmology , 1st affiliated hospital of Xi'an Jiaotong University , Xi'an , Shaanxi , China .

Purpose: To assess the effect of axial length (AL) on the quantification of superficial vessel density of both macular and disc region using swept source optical coherence tomography angiography (SSOCTA).

Methods: This is a cross-sectional clinical study. Seventy-five eyes from 75 Chinese healthy participants (56 females) with a mean age of 26. Read More

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http://dx.doi.org/10.1080/02713683.2019.1607393DOI Listing

Tumour expressions of hypoxic markers predict the response to neo-adjuvant chemotherapy in children with inoperable rhabdomyosarcoma.

Biomarkers 2019 Apr 17:1-31. Epub 2019 Apr 17.

a Department of Paediatrics, Haematology and Oncology , Medical University of Gdansk , Poland.

Objective The study was to assess whether tumour expressions of hypoxia-inducible factor (HIF)-1α, glucose transporter (GLUT)-1, carbonic anhydrase (CA)IX and vascular endothelial growth factor (VEGF) predict response to neo-adjuvant chemotherapy (naCHT) in children with inoperable rhabdomyosarcoma (RMS). Methods Immunohistochemical expressions of hypoxia markers were determined semi-quantitatively in tumour tissue microarray of 46 patients with embryonal RMS (RME) and 20 with alveolar (RMA), treated with CWS protocols (1992-2013). Results In paediatric RME, response to naCHT was influenced significantly by tumour expression of CA IX and GLUT-1. Read More

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https://www.tandfonline.com/doi/full/10.1080/1354750X.2019.1
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http://dx.doi.org/10.1080/1354750X.2019.1606275DOI Listing
April 2019
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Narratives About Autism: An Analysis of YouTube Videos by Individuals Who Self-Identify as Autistic.

Am J Speech Lang Pathol 2019 Apr 17:1-22. Epub 2019 Apr 17.

Department of Speech and Hearing Science, University of Illinois at Urbana-Champaign.

Purpose The goal of this study was to expand the field's understanding of autism through the analysis of 1st-person perspectives from autistic video webloggers (vloggers). Method This study analyzed the representation of autism in 39 YouTube videos authored by self-identified autistic individuals and published between 2007 and 2015. Consistent with the cross-disciplinary tradition of narrative inquiry, thematic analyses of the video transcripts were conducted. Read More

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http://dx.doi.org/10.1044/2018_AJSLP-18-0045DOI Listing

AMPK-mediated activation of Akt protects renal tubular cells from stress-induced apoptosis and ameliorates ischemic AKI .

Am J Physiol Renal Physiol 2019 Apr 17. Epub 2019 Apr 17.

Medicine / Nephroloy, University of Illinois, Chicago, United States.

We have reported that preconditioning renal tubular cells (RTCs) with A-769662 (a pharmacologic activator of AMPK) reduces apoptosis of RTCs induced by subsequent stress, and ameliorates the severity of ischemic AKI in mice. In this study we examined the role of the PI3K/Akt pathway in mediating these effects. To confirm that any observed novel effects of A-769662 are mediated specifically by AMPK, we developed knockdown ("KD") RTCs using shRNA. Read More

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https://www.physiology.org/doi/10.1152/ajprenal.00553.2018
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http://dx.doi.org/10.1152/ajprenal.00553.2018DOI Listing
April 2019
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