1,779,277 results match your criteria B E Journal Of Economic Analysis & Policy[Journal]


Discovery of coumarin Mannich base derivatives as multifunctional agents against monoamine oxidase B and neuroinflammation for the treatment of Parkinson's disease.

Eur J Med Chem 2019 Apr 12;173:203-212. Epub 2019 Apr 12.

Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China. Electronic address:

Due to the complexity of the pathogenesis of Parkinson's disease (PD), multimodal treatment may achieve better results. In this study, a series of coumarin Mannich base derivatives were designed and synthesized as multifunctional agents for PD treatment. Among the derivatives, 3-(3-(dimethylamino)propanoyl)-7-hydroxy-5-methyl- 2H-chromen-2-one hydrochloride (24) exhibited the most potent and selective hMAO-B inhibitory activity, and anti-inflammatory and neuroprotective effects in the in vitro studies. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.04.016DOI Listing

Factors affecting knee abduction during weight-bearing activities in individuals with anterior cruciate ligament reconstruction.

Phys Ther Sport 2019 Apr 12;38:8-15. Epub 2019 Apr 12.

School of Exercise Science, Australian Catholic University, Brisbane, Australia.

Objective: To investigate if muscle strength and muscle activation patterns are associated with increased knee abduction during two functional tasks, commonly used in rehabilitation for individuals with anterior cruciate ligament reconstruction (ACLR).

Design: Cross-sectional study.

Setting: Laboratory. Read More

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http://dx.doi.org/10.1016/j.ptsp.2019.04.006DOI Listing
April 2019
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Unraveling the solubilization and cytotoxicity study of poorly water-soluble anti-inflammatory drug in aqueous Gemini surfactants solution with physicochemical characterization and simulation study.

Colloids Surf B Biointerfaces 2019 Mar 28;179:437-444. Epub 2019 Mar 28.

Applied Chemistry Department, Sardar Vallabhbhai National Institute of Technology (SVNIT), Ichchhanath, Surat, 395 007, Gujarat, India. Electronic address:

This work investigates the use of quaternary ammonium based Gemini surfactants (GS) to examine the solubilization and stabilization of a poorly water soluble anti-inflammatory drug Diclofenac (Df). Here we demonstrate the effect of pH on the suspension profile of Df release where it exhibits maximum solubility and absorbance at pH = 10. Interaction process of such cationic GS with Df have been systematically characterized using tensiometry and UV-vis spectroscopy techniques from pre-micellar to post-micellar regions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09277765193020
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http://dx.doi.org/10.1016/j.colsurfb.2019.03.059DOI Listing
March 2019
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Corrosion resistance and antibacterial properties of hydroxyapatite coating induced by gentamicin-loaded polymeric multilayers on magnesium alloys.

Colloids Surf B Biointerfaces 2019 Apr 13;179:429-436. Epub 2019 Apr 13.

College of Materials Science and Engineering, Chongqing University of Technology, Chongqing, 400065, China.

As a result of their good biocompatibility, bioactivity, and mechanical properties, magnesium (Mg) alloys have received considerable attention as next generation biodegradable implants. Herein, in order to achieve a proper degradation rate and good antibacterial ability, we reported a novel hydroxyapatite coating induced by gentamicin (GS)-loaded polymeric multilayers for the surface treatment of the Mg alloy. The coating was characterized by X-ray diffraction, fourier transform infrared spectroscopy and scanning electron microscopy. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.04.029DOI Listing

Salvia officinalis extract mitigates the microbiologically influenced corrosion of 304L stainless steel by Pseudomonas aeruginosa biofilm.

Bioelectrochemistry 2019 Apr 11;128:193-203. Epub 2019 Apr 11.

Shenyang National Laboratory for Materials Science, Northeastern University, Shenyang 110819, China.

The mitigation of microbiologically influenced corrosion (MIC) of 304L stainless steel (SS) against Pseudomonas aeruginosa by a Salvia officinalis extract was investigated using electrochemical and surface analysis techniques. The extract was characterized by HPLC-Q-TOF-MS and its antibiofilm property was evaluated. The data revealed the presence of well-known antimicrobial and anticorrosion compounds in the extract. Read More

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http://dx.doi.org/10.1016/j.bioelechem.2019.04.006DOI Listing

Pseudolaric acid B exhibits anti-cancer activity on human hepatocellular carcinoma through inhibition of multiple carcinogenic signaling pathways.

Phytomedicine 2018 Nov 19;59:152759. Epub 2018 Nov 19.

Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), West China Second University Hospital, Sichuan University, Chengdu, China. Electronic address:

Background: Pseudolaric acid B (PAB), a diterpene acid isolated from the root bark of Pseudolarix kaempferi, exhibits a potent anti-cancer activity in a variety of tumor cells.

Purpose: The present study was designed to evaluate the anti-cancer effects of PAB on hepatocellular carcinoma (HCC) cell lines in vitro, and to explore the underlying mechanism.

Methods: The anti-proliferative activity of PAB on HCC cells were assessed via sulforhodamine B staining, colony formation, cell cycle analysis, respectively. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.11.019DOI Listing
November 2018

Phosphodiesterase-4 Inhibitor Roflumilast Attenuates Pulmonary Air Emboli-Induced Lung Injury.

J Surg Res 2019 Apr 17;241:24-30. Epub 2019 Apr 17.

Division of Pulmonary Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, School of Medicine, Tzu-Chi University, Hualien, Taiwan. Electronic address:

Background: Pulmonary air embolism (PAE)-induced acute lung injury (ALI) can be caused by massive air entry into the lung circulation. PAE can occur during diving, aviation, and some iatrogenic invasive procedures. PAE-induced ALI presents with severe inflammation, hypoxia, and pulmonary hypertension, and it is a serious complication resulting in significant morbidity and mortality. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00224804193014
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http://dx.doi.org/10.1016/j.jss.2019.03.028DOI Listing
April 2019
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NIR absorbing reduced graphene oxide for photothermal radiotherapy for treatment of esophageal cancer.

J Photochem Photobiol B 2019 Mar 22;194:188-193. Epub 2019 Mar 22.

Department of Radiotherapy, Linyi Cancer Hospital, Shandong, China. Electronic address:

Theranostic agents were drawing a huge attention in the personalized medication. In this study, we established a facile technique, plant extract-based technique for the synthesis of reduced nano-graphene oxide (RNGO) with low cytotoxicity. We formed platforms of photothermal (PT) therapy and further explained that the synthesized RNGO can be utilized as ready to use PT therapy without any additional surface adjustment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10111344193020
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http://dx.doi.org/10.1016/j.jphotobiol.2019.03.014DOI Listing
March 2019
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Synthesis of Nomega-Nitro-l-arginine methyl ester modified reduced graphene oxide nanosheets and their protective action on experimental preeclampsia in mice.

J Photochem Photobiol B 2019 Mar 22;194:183-187. Epub 2019 Mar 22.

Department of Gynaecology and Obstetrics, Jinan Maternal and Child Health Hospital of Shandong Province, Shandong, China. Electronic address:

The purpose of this study is to synthesize Nomega-Nitro-L-arginine methyl ester (L-NAME) adsorbed reduced graphene oxide (RGO) sheets and demonstrate their protective impact on the detrimental effect detected in investigational pre-eclampsia, a prerequisite where increase in oxidative stress and decreased Nitric Oxide (NO) production were present. The synthesized graphene sheets were studies by using various characterization techniques. Later, a prerequisite similar to pre-eclampsia has been induced through chronic inhibition of NO fabrication using a 60 mg/kg/day L-NAME, orally in pregnant mice. Read More

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http://dx.doi.org/10.1016/j.jphotobiol.2019.03.013DOI Listing

Different Effects of Intravenous, Topical and Combined Application of Tranexamic Acid on Patients with Thoracolumbar Fracture.

World Neurosurg 2019 Apr 17. Epub 2019 Apr 17.

Doctor, Department of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, No. 555 Youyi East Road, Xi'an, Shaanxi, China. Electronic address:

Objective: To observe the efficacy of intravenous, topical and combined application of tranexamic acid (TXA) in patients with thoracolumbar fracture fixed with percutaneous pedicle screw, and to identify the optimal application method of TXA.

Methods: A total of 181 thoracolumbar fracture patients treated with percutaneous pedicle screw fixation were enrolled in the current randomized controlled clinical trial, and were randomly classified as three groups, including group A (intravenous group), group B (topical group), and group C (combined group). At the same time, the total blood loss (TBL), hidden blood loss (HBL), intraoperative blood loss (IBL), preoperative d-dimer, postoperative d-dimer, incidence of deep vein thrombosis (DVT) and other complications were compared and analyzed among these three groups. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.095DOI Listing

Simultaneous determination of pesticides, mycotoxins, and metabolites as well as other contaminants in cereals by LC-LC-MS/MS.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Apr 6;1117:86-102. Epub 2019 Apr 6.

Food Chemistry, Technical University Dresden, Bergstraße 66, D-01069 Dresden, Germany.

A 2D LC-MS/MS method for the simultaneous determination of 350 pesticides, 16 mycotoxins as well as the growth regulators Chlormequat and Mepiquat was developed. The method is applicable to cereals and products thereof. Attention should be paid to the simultaneous analysis of the cereal-relevant mycotoxins aflatoxin B1, B2, G1 and G2, ochratoxin A, deoxynivalenol and zearalenone. Read More

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http://dx.doi.org/10.1016/j.jchromb.2019.04.013DOI Listing

Development and validation of an ultra-high performance liquid chromatography-tandem mass spectrometry method for the simultaneous determination of iohexol, p-aminohippuric acid and creatinine in porcine and broiler chicken plasma.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Apr 8;1117:77-85. Epub 2019 Apr 8.

Department of Pharmacology, Toxicology and Biochemistry, Salisburylaan 133, Ghent University, Merelbeke, Belgium. Electronic address:

In order to study the renal function, in terms of glomerular filtration and effective renal plasma flow, in broiler chickens and pigs, an ultra-high performance liquid chromatography-tandem mass spectrometry method for the simultaneous determination of iohexol, p-aminohippuric acid (PAH) and exogenously administered creatinine in plasma was developed and validated. Sample preparation consisted of a deproteinization step using methanol for porcine plasma and an Ostro™ Protein Precipitation & Phospholipid Removal Plate was used for broiler chicken plasma. Chromatographic separation was achieved on a Hypersil Gold aQ column using 0. Read More

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http://dx.doi.org/10.1016/j.jchromb.2019.04.017DOI Listing

An LC-MS/MS method to profile urinary mercapturic acids, metabolites of electrophilic intermediates of occupational and environmental toxicants.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Apr 6;1117:66-76. Epub 2019 Apr 6.

EPIGET - Epidemiology, Epigenetics, and Toxicology Lab, Department of Clinical Sciences and Community Health, University of Milan and Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, via S. Barnaba, 8, 20122 Milan, Italy. Electronic address:

Introduction: Mercapturic acids are urinary metabolites of occupational and environmental toxicants. The aim of this work was to develop and validate an analytical assay for the determination of several urinary mercapturic acids to be used as biomarkers of exposure.

Method: An isotope dilution tandem mass spectrometric method, coupled with reversed-phase liquid chromatography, was developed for the analysis of mercapturic acids derived from several compounds, including those of benzene, toluene, 1,3-butadiene, styrene, acrylonitrile, 4-chloronitrobenzene, acrylamide, acrolein, propylene oxide, N,N-dimethylformamide, crotonaldehyde, ethylene oxide, and methylating and ethylating agents. Read More

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http://dx.doi.org/10.1016/j.jchromb.2019.04.015DOI Listing

Interaction between charged lipid vesicles and point- or rod-like trivalent ions.

Colloids Surf B Biointerfaces 2019 Feb 20;178:525-529. Epub 2019 Feb 20.

Faculty of Health Sciences, University of Ljubljana, Zdravstvena 5, SI-1000 Ljubljana, Slovenia. Electronic address:

This work examines the influence of the charge distribution of trivalent cations on their interaction with soft anionic particles, using a combination of experimental measurements and theoretical modelling. In particular, we perform electrophoresis measurements to determine the zeta-potential of anionic liposomes in the presence of spermidine and lanthanum cations. We work in a range of electrolyte concentration where a reversal in the electrophoretic mobility of the liposomes is expected; however, unlike the case of lanthanum cations, spermidine does not induce mobility reversal of liposomes. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.02.010DOI Listing
February 2019

Low-cost internal controls for detection of Giardia cysts in water samples.

Parasitol Int 2019 Apr 17. Epub 2019 Apr 17.

Sección Infección Nutrición, Instituto de Investigaciones en Salud (INISA), Universidad de Costa Rica, 11501-2060 San José, Costa Rica.

Giardia cysts stained with hot carbolfuchsin were used as internal controls in a concentration method for surface water samples. The morphological integrity of stained cysts and the stain's stability and intensity weretested with each of the chemical reagents used in the aluminum sulfate flocculation method. No alterations in morphology or color were noted. Read More

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http://dx.doi.org/10.1016/j.parint.2019.04.012DOI Listing

Lipid-modulation of membrane insertion and refolding of the apoptotic inhibitor Bcl-xL.

Biochim Biophys Acta Proteins Proteom 2019 Apr 17. Epub 2019 Apr 17.

Department of Biochemistry and Molecular Biology, University of Kansas Medical Center,Kansas City, KS 66160, USA. Electronic address:

Bcl-xL is a member of the Bcl-2 family of apoptotic regulators, responsible for inhibiting the permeabilization of the mitochondrial outer membrane, and a promising anti-cancer target. Bcl-xL exists in the following conformations, each believed to play a role in the inhibition of apoptosis: (a) a soluble folded conformation, (b) a membrane-anchored (by its C-terminal α8 helix) form, which retains the same fold as in solution and (c) refolded membrane-inserted conformations, for which no structural data are available. Previous studies established that in the cell Bcl-xL exists in a dynamic equilibrium between soluble and membranous states, however, no direct evidence exists in support of either anchored or inserted conformation of the membranous state in vivo. Read More

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http://dx.doi.org/10.1016/j.bbapap.2019.04.006DOI Listing

Respiratory virus infection amongst hospitalized adult patients with or without clinically-apparent respiratory infection: a prospective cohort study.

Clin Microbiol Infect 2019 Apr 17. Epub 2019 Apr 17.

Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China; Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China; Department of Microbiology, Queen Mary Hospital, Pokfulam, Hong Kong Special Administrative Region, China; State Key Laboratory for Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China; Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong Special Administrative Region, China. Electronic address:

Objectives: We aimed to determine the viral epidemiology and clinical characteristics of patients with and those without clinically-apparent respiratory tract infection.

Methods: This prospective cohort study was conducted during the 2018 winter influenza season. Adult patients with fever/respiratory symptoms (fever/RS group) were age- and sex-matched with patients without fever/respiratory symptoms (non-fever/RS group) in a 1:1 ratio. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.04.012DOI Listing

Bartonella diversity and zoonotic potential in indigenous Tete Veld rats (Aethomys ineptus) from South Africa.

Infect Genet Evol 2019 Apr 17. Epub 2019 Apr 17.

Mammal Research Institute (MRI), Department of Zoology and Entomology, University of Pretoria, Private Bag 20, Hatfield 0028, South Africa. Electronic address:

Bartonellosis is a vector-borne disease that is often misdiagnosed due to a broad range of clinical symptoms, compounded by a lack of awareness regarding the prevalence, diversity and public health impacts of regional strains. Despite recent PCR-based confirmation of Bartonella in 9.7% of non-malarial, acute febrile patients in South Africa, data regarding reservoirs of infection are limited. Read More

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http://dx.doi.org/10.1016/j.meegid.2019.04.012DOI Listing

Impact of the replacement of dietary fish oil by animal fats and environmental salinity on the metabolic response of European Seabass (Dicentrarchus labrax).

Comp Biochem Physiol B Biochem Mol Biol 2019 Apr 17. Epub 2019 Apr 17.

CIIMAR-Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Portugal. Electronic address:

The replacement of fish oil (FO) with other lipid sources (e.g. animal fats, AF) in aquafeeds improves the sustainability of aquaculture, even though alternatives have different fatty acid (FA) profiles. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10964959183032
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http://dx.doi.org/10.1016/j.cbpb.2019.04.004DOI Listing
April 2019
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Ameliorative effect of Atractylodes macrocephala essential oil combined with Panax ginseng total saponins on 5-fluorouracil induced diarrhea is associated with gut microbial modulation.

J Ethnopharmacol 2019 Apr 17:111887. Epub 2019 Apr 17.

College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China. Electronic address:

Ethnopharmacological Relevance: Traditional Chinese medicine (TCM) holds that deficiency of spleen-Qi is the major pathogenesis of chemotherapy-induced diarrhea (CID). Herb pair of Atractylodes macrocephala Koidz. (AM) and Panax ginseng C. Read More

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http://dx.doi.org/10.1016/j.jep.2019.111887DOI Listing
April 2019
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Cytotoxic polyphenolic compounds from Lespedeza bicolor stem bark.

Fitoterapia 2019 Apr 17. Epub 2019 Apr 17.

G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Prospect 100-let Vladivostoku 159, Vladivostok, 690022, Russia.

Four new pterocarpans (6aR,11aR)-6a,11a-dihydrolespedezol A (2), (6aR,11aR)-2-isoprenyl-6a,11a-dihydrolespedezol A (3), (6aR,11aR,3'R)-6a,11a-dihydrolespedezol A (4), (6aR,11aR,3'S)-6a,11a-dihydrolespedezol A (5) and one new stilbenoid with 1,2-diketone fragment named bicoloketone (6) along with one previously known pterocarpen lespedezol A (1) have been isolated from Lespedeza bicolor stem bark using multistage column chromatography on polyamide and silica gel. The structures of the isolated polyphenolic compounds were determined by spectroscopic methods. The absolute configurations of 4 and 5 were determined by comparison of their electronic circular dichroism (ECD) spectra obtained experimentally and the spectra calculated using time-dependent density functional theory (TDDFT). Read More

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http://dx.doi.org/10.1016/j.fitote.2019.04.003DOI Listing

Update of the statements on biology and clinical impact of occult hepatitis b virus infection.

J Hepatol 2019 Apr 17. Epub 2019 Apr 17.

Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA.

In October 2018 a large number of international experts with complementary expertise came together in Taormina to participate in a workshop on occult hepatitis B virus infection (OBI). The objectives of the workshop were to review the existing knowledge on OBI, to identify issues that require further investigation, to highlight both the existing controversial and newly emerging aspects, and ultimately to update the statements previously agreed in 2008. This paper represents the output from the workshop. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01688278193025
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http://dx.doi.org/10.1016/j.jhep.2019.03.034DOI Listing
April 2019
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Targeting non-oncogene ROS pathway by alantolactone in B cell acute lymphoblastic leukemia cells.

Life Sci 2019 Apr 17. Epub 2019 Apr 17.

Department of Hematology, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China; Department of General Practice, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China. Electronic address:

Aims: Alantolactone (ALT) is active component of natural product Inula helenium with a lot of pharmacological effects, including anti-tumor effect. The present work aimed to explore the antitumor effect of ALT in B cell acute lymphoblastic leukemia (B-ALL).

Main Methods: B-ALL cells were treated with various concentrations of ALT, and then trypan blue assay, Annexin V/PI staining assay, PI staining assay, western blot analysis were employed to measure the effect of ALT on viability, apoptosis and cell cycle in B-ALL cells. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00243205193029
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http://dx.doi.org/10.1016/j.lfs.2019.04.034DOI Listing
April 2019
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Isolation and structural characterization of a levan produced by probiotic Bacillus tequilensis-GM from Tunisian fermented goat milk.

Int J Biol Macromol 2019 Apr 17. Epub 2019 Apr 17.

Department of Chemical Sciences, University of Naples "Federico II", Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Naples, Italy.

The probiotic features of strain GM newly isolated from Tunisian spontaneously fermented goat milk and identified as Bacillus tequilensis-GM were assessed. Strain GM showed high resistance to saliva (90.64%), gastric juice (88. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01418130193052
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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.130DOI Listing
April 2019
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An optimized cocktail of chitinolytic enzymes to produce N,N'-diacetylchitobiose and N-acetyl-d-glucosamine from defatted krill by-products.

Int J Biol Macromol 2019 Apr 17. Epub 2019 Apr 17.

State Key Laboratory of Fine Chemical Engineering and School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, China; Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China. Electronic address:

Defatted krill powder (DKP), the byproduct of krill oil industry, is a resource of biological macromolecules. Here, one bacterial protease, three bacterial chitinases and one insect N-acetyl-d-hexosaminidase were integratively used to produce peptide, N,N'-diacetylchitobiose [(GlcNAc)] and N-acetyl-d-glucosamine (GlcNAc) from DKP. First, alkaline protease was found to outperform neutral protease in deproteinizing DKP and the resultant krill peptides were rich in essential amino acids (41. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.114DOI Listing

Composite edible coatings from commercial pectin, corn flour and beetroot powder minimize post-harvest decay, reduces ripening and improves sensory liking of tomatoes.

Int J Biol Macromol 2019 Apr 17. Epub 2019 Apr 17.

Center of Innovative and Applied Bioprocessing (CIAB), Sector-81 (Knowledge City), Mohali 140306, Punjab, India. Electronic address:

The present study aimed to enhance the shelf life of tomatoes at pink-red stage through pectin (P), corn flour (CF) and beetroot powder (B) based coatings. PCF11 coating was resulted in significant enhancement of shelf life and quality retention of tomato in terms of physiological weight loss (PWL), decay per cent, ripening index, respiration rate, hue angle, firmness and DPPH antioxidant activity. Lower amounts of glucose and fructose quantified through HPLC indicated lesser cell wall components degradation in tomatoes coated with P and PCF11. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.132DOI Listing

Pro-apoptotic and anti-inflammatory effects of araloside A on human rheumatoid arthritis fibroblast-like synoviocytes.

Chem Biol Interact 2019 Apr 17. Epub 2019 Apr 17.

Department of Rheumatology and Immunology, Huaihe Hospital of Henan University, Kaifeng, 475000, Henan, China. Electronic address:

Rheumatoid arthritis fibroblast-like synoviocytes play an essential role in the occurrence and progression of rheumatoid arthritis. As the main pharmacologically active components of Aralia taibaiensis, total saponins, particularly triterpenoid saponins, have been shown to possess multiple pharmacological activities including relieving rheumatism. However, the effect of araloside A, a triterpenoid saponin extracted from the root bark of Aralia taibaiensis, on rheumatoid arthritis remains unknown. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.04.025DOI Listing

Post-Concussion: Receded Near Point of Convergence is Not Diagnostic of Convergence Insufficiency.

Am J Ophthalmol 2019 Apr 17. Epub 2019 Apr 17.

Department of Ophthalmology, Boston Children's Hospital, Boston, MA; Department of Ophthalmology, Harvard Medical School; Department of Ophthalmology, Massachusetts Eye and Ear, Boston, MA.

Purpose: To determine the frequency of receded near point of convergence (NPC) in patients with chronic concussion-related symptoms, and among those with receded NPC to enumerate the frequency of convergence insufficiency and other oculomotor disorders.

Study: Design: Retrospective cross-sectional study METHODS: Clinic charts were retrospectively reviewed for the prior 3.5 years to identify all patients <21 years old who were >28 days post-concussion, had chronic concussion-related symptoms, had normal visual acuity, and received a comprehensive sensorimotor examination. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.04.008DOI Listing

Retinal Vessel Phenotype in Patients with Non-Arteritic Anterior Ischemic Optic Neuropathy.

Am J Ophthalmol 2019 Apr 17. Epub 2019 Apr 17.

Department of ophthalmology, University Hospital of Grenoble-Alpes, France; Grenoble-Alpes University, HP2 Laboratory, INSERM U1042, Grenoble, France; Department of Ophthalmology, University Hospital of Grenoble-Alpes, Grenoble, France. Electronic address:

Purpose: The pathophysiology of non-arteritic AION (N-AION) is not completely understood. Studies of the retinal vasculature phenotype in patients with N-AION could help us to understand vascular abnormalities associated with the disease.

Design: Retrospective case series with matched controls. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.04.007DOI Listing

Development of a novel multiplex electrochemiluminescent-based immunoassay to aid enterotoxigenic Escherichia coli vaccine development and evaluations.

J Immunol Methods 2019 Apr 17. Epub 2019 Apr 17.

Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Enterotoxigenic Escherichia coli (ETEC) is a leading cause of bacterial diarrhea both among children in low and middle income countries and in travelers to these regions. Although there are several approaches to develop an effective vaccine for ETEC, no licensed vaccines are currently available. The most advanced ETEC vaccine candidates include multiple colonization factors along with the heat labile toxin B subunit. Read More

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http://dx.doi.org/10.1016/j.jim.2019.04.003DOI Listing

Intranasal immunization with recombinant Trichinella spiralis serine protease elicits protective immunity in BALB/c mice.

Exp Parasitol 2019 Apr 17. Epub 2019 Apr 17.

Department of Parasitology, Medical College, Zhengzhou University, 40 Daxue Road, Zhengzhou, 450052, PR China. Electronic address:

The aim of this study was to observe the intestinal mucosal/systemic responses triggered by intranasal vaccination using recombinant Trichinella spiralis serine protease (rTsSP) and its capacity to elicit immune protection against larva challenge in a murine model. rTsSP coupled with cholera toxin B subunit (CTB) was used to vaccinate mice via intranasal route. The results revealed that intranasal vaccination with rTsSP plus CTB elicited significantly intestinal local sIgA response and a TsSP-specific systemic antibody response in vaccinated mice. Read More

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http://dx.doi.org/10.1016/j.exppara.2019.04.006DOI Listing

Femoral Artery Sclerosis Evaluation by Tissue Doppler in Patients with Hypertension.

Med Sci Monit 2019 Apr 20;25:2917-2922. Epub 2019 Apr 20.

Department of Ultrasonography, Tianjin Union Medical Center (Tianjin People's Hospital), Tianjin, China (mainland).

BACKGROUND The aim of this study was to evaluate the early femoral sclerosis in hypertensive patients by using tissue Doppler imaging (TDI). MATERIAL AND METHODS One hundred patients with hypertension were recruited and divided into group A (femoral artery intima-media thicknesses (IMT) ≥1.0 mm) and group B (femoral artery IMT <1. Read More

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https://www.medscimonit.com/abstract/index/idArt/913271
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http://dx.doi.org/10.12659/MSM.913271DOI Listing
April 2019
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Effect of Combination NSAID and NBUVB treatment in Non-Photoadapters - A Pilot Study.

Photodermatol Photoimmunol Photomed 2019 Apr 20. Epub 2019 Apr 20.

Department of Dermatology, Henry Ford Hospital, Detroit, MI.

Background: Vitiligo is a disorder of dyspigmentation that can impact quality of life. While narrow band ultraviolet B (NBUVB) is an effective treatment for vitiligo, a sub-set of patients are unable to respond to phototherapy as they cannot photoadapt. However, nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to increase the minimal erythema dose. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/phpp.12476
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http://dx.doi.org/10.1111/phpp.12476DOI Listing
April 2019
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Defective Leptotene Chromosome 1 (DLC1) encodes a type-B response regulator and is required for rice meiosis.

Plant J 2019 Apr 20. Epub 2019 Apr 20.

State Key Laboratory of Hybrid Rice, Rice Research Institute, Sichuan Agricultural University, Chengdu, 611130, China.

Meiosis is critical for sexual reproduction and the generation of new allelic variations in most eukaryotes. In this study, we report the isolation of a meiotic gene, DLC1, using a map-based cloning strategy. The dlc1 mutant is sterile in both male and female gametophytes due to an earlier defect in the leptotene chromosome and subsequent abnormalities at later stages. Read More

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http://dx.doi.org/10.1111/tpj.14344DOI Listing

Cognitive-behavioral therapy (CBT) for generalized anxiety disorder: Contrasting various CBT approaches in a randomized clinical trial.

J Clin Psychol 2019 Apr 20. Epub 2019 Apr 20.

Department of Clinical Psychology and Psychotherapy/International Institute for the Advanced Study of Psychotherapy and Applied Mental Health, Babeş-Bolyai University, No 37 Republicii Street, Cluj-Napoca, Romania.

Objective: Cognitive-behavior therapy (CBT) is considered the "golden standard" psychotherapy for generalized anxiety disorder (GAD) but, at this point, we have little information about differences among various CBT approaches.

Method: We conducted a randomized controlled trial to compare three CBT protocols for GAD: (a) Cognitive Therapy/Borkovec's treatment package; (b) Rational Emotive Behavior Therapy, and (c) Acceptance and Commitment Therapy/Acceptance-based behavioral therapy. A number of 75 patients diagnosed with GAD, aged between 20 and 51 (m = 27. Read More

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http://dx.doi.org/10.1002/jclp.22779DOI Listing

Different routes and formulations of melatonin in critically-ill patients. A pharmacokinetic randomized study.

Clin Endocrinol (Oxf) 2019 Apr 20. Epub 2019 Apr 20.

Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Italy.

Background And Objectives: Critically-ill patients present reduced endogenous melatonin blood levels, and they might benefit from its exogenous supplementation. The aim of this research was to evaluate the feasibility of different routes of administration and drug formulations of melatonin. The efficiency of absorption was assessed as well as the adequacy in achieving and maintaining the physiological nocturnal blood peak. Read More

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http://dx.doi.org/10.1111/cen.13993DOI Listing

Stable mutants of restriction-deficient/modification-proficient Bacillus subtilis 168: Hub strains for giant DNA engineering.

J Biochem 2019 Apr 20. Epub 2019 Apr 20.

Institute for Advanced Biosciences, Keio University, Nipponkoku, Daihoji, Tsuruoka-shi, Yamagata, Japan.

Bacillus subtilis 168 has been explored as a platform for the synthesis and transmission of large DNA. Two inherent DNA incorporation systems, natural transformation and pLS20-based conjugation transfer, enable rapid handling of target DNA. Both systems are affected by the Bsu restriction-modification system that recognizes and cleaves unmethylated XhoI sites, limiting the choice of target DNA. Read More

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http://dx.doi.org/10.1093/jb/mvz031DOI Listing

Characteristics, transcriptional patterns and possible physiological significance of glycoside hydrolase family 16 members in Coprinopsis cinerea.

FEMS Microbiol Lett 2019 Apr 20. Epub 2019 Apr 20.

Jiangsu Key Laboratory for Microbes and Microbial Functional Genomics, Jiangsu Engineering and Technology Research Center for Industrialization of Microbial Resources, College of Life Science, Nanjing Normal University, Nanjing 210023, PR China.

The glycoside hydrolase (GH) 16 family of Coprinopsis cinerea includes fifteen members distributed in four subgroups (A1, A2, B and D) by phylogenetic analysis. The expression patterns match well with the requirement of wall-softening in the germination of basidiospores, hyphal growth and branching, primordium formation, stipe elongation, pileus expansion and autolysis. Remarkably, expression levels of different GH16 members varied with different morphogenetic events. Read More

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http://dx.doi.org/10.1093/femsle/fnz083DOI Listing

Influence of rifampin-mediated OATP1B1/1B3 inhibition on the pharmacokinetics of clazosentan.

Clin Transl Sci 2019 Apr 20. Epub 2019 Apr 20.

Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.

Clazosentan is a selective endothelin A receptor antagonist in development for prevention and treatment of vasospasm post subarachnoid hemorrhage. It is a substrate of organic-anion-transporting polypeptide (OATP)1B1/1B3 based on preclinical data. This randomized, double-blind, two-period cross-over study investigated the pharmacokinetics, safety, and tolerability of an intravenous (i. Read More

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http://dx.doi.org/10.1111/cts.12639DOI Listing

Pleomorphic mantle cell lymphoma mimicking diffuse large B cell lymphoma in peripheral blood and bone marrow.

Am J Hematol 2019 Apr 20. Epub 2019 Apr 20.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.

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http://dx.doi.org/10.1002/ajh.25491DOI Listing
April 2019
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The Genetic Diversity of Bactrocera dorsalis (Diptera: Tephritidae) in China and Neighboring Countries: A Review From Published Studies.

J Econ Entomol 2019 Apr 20. Epub 2019 Apr 20.

Center for Plant Health Science and Technology, Mission Laboratory, USDA-APHIS, Moore Air Base, Edinburg, TX.

For more than a decade, various research groups have tracked the population genetics of the oriental fruit fly, Bactrocera dorsalis (Hendel) in China and neighboring countries using mitochondrial cytochrome c oxidase subunit I (COI) DNA. Although most research has reported high levels of mtDNA variation, to date no efforts have been made to integrate and compare the results from these studies simultaneously. Here, we show that: 1) despite the fact that a large portion of the sampling effort has focused on the Yunnan province beginning in 2005, each subsequent study recovers only a small number of previously sampled haplotypes; 2) new haplotypes of B. Read More

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https://academic.oup.com/jee/advance-article/doi/10.1093/jee
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http://dx.doi.org/10.1093/jee/toz073DOI Listing
April 2019
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Neural substrates of self- and external-preoccupation: A voxel-based morphometry study.

Brain Behav 2019 Apr 19:e01267. Epub 2019 Apr 19.

Department of Ubiquitous Sensing, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.

Introduction: Self- and external-preoccupation have been linked to psychopathological states. The neural substrates underlying self- and external-preoccupation remain unclear. In the present study, we aim to provide insight into the information-processing mechanisms associated with self- and external-preoccupation at the structural level. Read More

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http://dx.doi.org/10.1002/brb3.1267DOI Listing

Seasonal changes in the song control nuclei of the Rufous-bellied Thrush, Turdus rufiventris (Oscine, Passeriformes, and Turdidae).

J Exp Zool B Mol Dev Evol 2019 Apr 19. Epub 2019 Apr 19.

Instituto de Ciências Biológicas, Centro de Genômica e Biologia de Sistemas, Universidade Federal do Pará, Belém, Brazil.

In vocal learning birds, memorization and song production rely on a set of telencephalic nuclei referred to as the song control system. Seasonal changes in song production are correlated with changes in the volume of the song control nuclei and are influenced by photoperiodic conditions and hormonal cues. The seasonal volume changes in the avian brain that controls singing are thought to involve regulation of neuronal replacement, which is a striking example of neuronal plasticity. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jez.b.22853
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http://dx.doi.org/10.1002/jez.b.22853DOI Listing
April 2019
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Molecular characterization and expression analysis of a phosphoserine aminotransferase involving l-serine synthesis from silkworm, Bombyx mori.

Arch Insect Biochem Physiol 2019 Apr 19:e21553. Epub 2019 Apr 19.

Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.

In this study, we identified and characterized a phosphoserine aminotransferase (bmPSAT) from Bombyx mori (B. mori) that is responsible for l-serine biosynthesis. A complementary DNA that encodes bmPSAT was cloned by reverse transcriptase polymerase reaction and sequenced. Read More

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http://dx.doi.org/10.1002/arch.21553DOI Listing

Proton exchange in aqueous urea solutions measured by water-exchange (WEX) NMR spectroscopy and chemical exchange saturation transfer (CEST) imaging in vitro.

Magn Reson Med 2019 Apr 19. Epub 2019 Apr 19.

Department of Diagnostic and Interventional Radiology, Medical Faculty, Heinrich Heine University Düsseldorf, Dusseldorf, Germany.

Purpose: To characterize the proton exchange in aqueous urea solutions using a modified version of the WEX II filter at high magnetic field, and to assess the feasibility of performing quantitative urea CEST MRI on a 3T clinical MR system.

Methods: In order to study the dependence of the exchange-rate constant of urea as a function of pH and T, the WEX-spectra were acquired at 600 MHz from urea solutions in a pH range from 6.4 to 8. Read More

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http://dx.doi.org/10.1002/mrm.27778DOI Listing

9za plays cytotoxic and proapoptotic roles and induces cytoprotective autophagy through the PDK1/Akt/mTOR axis in non-small-cell lung cancer.

J Cell Physiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Non-small-cell lung cancer (NSCLC) is an aggressive subtype of pulmonary carcinomas with high mortality. However, chemotherapy drug resistance and high recurrence rates hinder the curative effect of platinum-based first-line chemotherapy, which makes it urgent to develop new antitumor drugs for NSCLC. 9za, a new candidate drug synthesized by our research group, has been verified with potent antilung cancer activity in preliminary experiments. Read More

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http://dx.doi.org/10.1002/jcp.28679DOI Listing
April 2019
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Is there a correlation between thyroiditis and thyroid cancer?

Endocrine 2019 Apr 19. Epub 2019 Apr 19.

Department of Clinical and Experimental Medicine, University Hospital of Parma, Parma, Italy.

Background: In the past few decades, the incidence of thyroid cancer has increased significantly all over the world. In the same period, there also seems to have been an increase in the incidence of Hashimoto's Thyroiditis-the most common inflammatory autoimmune thyroid disease. Several studies have linked thyroiditis to thyroid cancer. Read More

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http://dx.doi.org/10.1007/s12020-019-01935-8DOI Listing

In silico markers: an evolutionary and statistical approach to select informative genes of human breast cancer subtypes.

Genes Genomics 2019 Apr 19. Epub 2019 Apr 19.

Department of Informatics, University of Evora, 7004-516, Evora, Portugal.

Background: Recent advancement in bioinformatics offers the ability to identify informative genes from high dimensional gene expression data. Selection of informative genes from these large datasets has emerged as an issue of major concern among researchers.

Objective: Gene functionality and regulatory mechanisms can be understood through the analysis of these gene expression data. Read More

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http://dx.doi.org/10.1007/s13258-019-00816-8DOI Listing

Frailty index is associated with increased risk of elevated BNP in an elderly population: the Rugao Longevity and Ageing Study.

Aging Clin Exp Res 2019 Apr 19. Epub 2019 Apr 19.

State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Science and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.

Background And Aims: To explore whether frailty, defined by frailty index (FI), is associated with the risk of elevated B-type natriuretic peptide (BNP), a surrogate endpoint of cardiovascular events.

Methods: Data of 1382 community-dwelling elders who had no documented cardiovascular diseases aged 70-84 years from the ageing arm of the Rugao Longevity and Ageing Study was used. Traditional risk factor index (TI) was constructed using eight established cardiovascular-related risk factors. Read More

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http://link.springer.com/10.1007/s40520-019-01189-4
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http://dx.doi.org/10.1007/s40520-019-01189-4DOI Listing
April 2019
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Obstetric perineal tears: risk factors, wound infection and dehiscence: a prospective cohort study.

Arch Gynecol Obstet 2019 Apr 19. Epub 2019 Apr 19.

Department of Gynaecology and Obstetrics, Odense University Hospital, J.B. Winsløws Vej 4, 5000, Odense C, Denmark.

Purpose: To assess risk factors for perineal tears, wound infection and dehiscence among primiparous women.

Methods: A prospective cohort study at four Danish hospitals (Odense, Esbjerg, Aarhus and Kolding) among 603 primiparous women sampled in three groups: 203 with none/labia/1st degree, 200 with 2nd degree, and 200 with 3rd/4th degree tears included between July 2015 and January 2018. Baseline data were obtained and a clinical examination of perineal wound healing was performed 11-21 days postpartum. Read More

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http://link.springer.com/10.1007/s00404-019-05165-1
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http://dx.doi.org/10.1007/s00404-019-05165-1DOI Listing
April 2019
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