1,891,984 results match your criteria B E Journal Of Economic Analysis & Policy[Journal]


Dexamethasone suppresses radicular pain through targeting L-PGDS/PI3K/Akt pathway in rats with lumbar disc herniation.

Pain Pract 2020 Jul 8. Epub 2020 Jul 8.

Department of Orthopaedics, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, 310012, China.

The Purpose: Lumbar disc herniation (LDH) is a frequently occurring disease with unknown etiology, which makes treatment a challenge. The aim of this study was to analyze the effects of dexamethasone on LDH and elucidate the underlying mechanisms.

General Methods: LDH rat model was established by nucleus pulposus (NP) implantation. Read More

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http://dx.doi.org/10.1111/papr.12934DOI Listing

High microbiota reactivity of adult human intestinal IgA requires somatic mutations.

J Exp Med 2020 Nov;217(11)

Institute of Molecular Medicine, Rheinisch-Westfälische Technische Hochschule Aachen University, Aachen, Germany.

The gut is home to the body's largest population of plasma cells. In healthy individuals, IgA is the dominating isotype, whereas patients with inflammatory bowel disease also produce high concentrations of IgG. In the gut lumen, secretory IgA binds pathogens and toxins but also the microbiota. Read More

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http://dx.doi.org/10.1084/jem.20200275DOI Listing
November 2020

Remedial dosing recommendations for delayed or missed doses of valproic acid in patients with epilepsy based on Monte Carlo simulations.

Epilepsy Behav 2020 Jul 5;111:107265. Epub 2020 Jul 5.

Department of Neurology, Huashan Hospital, Fudan University, Shanghai, 200040, PR China.

Objective: Delayed or missed doses are unavoidable in the pharmacotherapy of epilepsy and significantly compromise the efficacy of antiepileptic drug treatment. An inappropriate remedial regimen can cause seizure relapse or serious adverse events. This study investigated the effect of delayed or missed doses on the pharmacokinetics (PK) of valproic acid (VPA) in patients with epilepsy and established remedial dosing recommendations for nonadherent patients. Read More

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http://dx.doi.org/10.1016/j.yebeh.2020.107265DOI Listing

Anticancer pentamethinium salt is a potent photosensitizer inducing mitochondrial disintegration and apoptosis upon red light illumination.

J Photochem Photobiol B 2020 Jun 23;209:111939. Epub 2020 Jun 23.

RECAMO, Masaryk Memorial Cancer Institute, Žlutý kopec 7, 656 53 Brno, Czech Republic. Electronic address:

Despite progress in the development and application of novel therapeutic agents, cancer remains a major cause of death worldwide. Therefore, there is a need for new approaches to increase therapeutic options and efficiency. The metabolism of cancer cells differs from that of non-malignant cells and their mitochondria show altered activities that can be utilized as a target for drug development. Read More

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http://dx.doi.org/10.1016/j.jphotobiol.2020.111939DOI Listing

Improvement of in vitro and in situ antifungal, AFB inhibitory and antioxidant activity of Origanum majorana L. essential oil through nanoemulsion and recommending as novel food preservative.

Food Chem Toxicol 2020 Jul 5:111536. Epub 2020 Jul 5.

Laboratory of Herbal Pesticides, Centre of Advanced Study (CAS) in Botany, Institute of Science, Banaras Hindu University, Varanasi, 221005, India. Electronic address:

Origanum majorana essential oil (OmEO) encapsulated into chitosan nanoemulsion is being reported as a novel preservative of stored food items against fungi, aflatoxin B (AFB) contamination and lipid peroxidation. The major component of OmEO identified through GC-MS was terpinen-4-ol (28.92%). Read More

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http://dx.doi.org/10.1016/j.fct.2020.111536DOI Listing

Further delineation of bone marrow failure syndrome caused by novel compound heterozygous variants of MYSM1.

Gene 2020 Jul 5:144938. Epub 2020 Jul 5.

Department of Medical Genetics and Molecular Diagnostic Laboratory, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China; Institute of Pediatric Translational Medicine, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China. Electronic address:

Myb-like SWIRM and MPN domains (MYSM1) is a chromatin-binding transcriptional regulator that mediates histone 2A deubiquitination, which plays a vital role in hematopoiesis and lymphocyte differentiation. Biallelic variants in MYSM1 cause a rare bone marrow failure syndrome (OMIM #618116). To date, only three pathogenic variants (E390*, R478*, and H656R) of MYSM1 have been reported in nine patients, and all variants are homozygous. Read More

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http://dx.doi.org/10.1016/j.gene.2020.144938DOI Listing

Use of computational toxicology (CompTox) tools to predict in vivo toxicity for risk assessment.

Authors:
M H Silva

Regul Toxicol Pharmacol 2020 Jul 5:104724. Epub 2020 Jul 5.

Retired from a Career in Regulatory Toxicology and Risk Assessment, 2437 Evenstar Lane, Davis, CA, 95616, USA. Electronic address:

Computational Toxicology tools were used to predict toxicity for three pesticides: propyzamide (PZ), carbaryl (CB) and chlorpyrifos (CPF). The tools used included: a) ToxCast/Tox21 assays (AC s μM: concentration 50% maximum activity); b) in vitro-to-in vivo extrapolation (IVIVE) using ToxCast/Tox21 ACs to predict administered equivalent doses (AED: mg/kg/d) to compare to known in vivo Lowest-Observed-Effect-Level (LOEL)/Benchmark Dose (BMD); c) high throughput toxicokinetics population based (HTTK-Pop) using ACs for endpoints associated with the mode of action (MOA) to predict age-adjusted AED for comparison with in vivo LOEL/BMDs. ToxCast/Tox21 active-hit-calls for each chemical were predictive of targets associated with each MOA, however, assays directly relevant to the MOAs for each chemical were limited. Read More

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http://dx.doi.org/10.1016/j.yrtph.2020.104724DOI Listing

Finding the Sweet Spot: Parsing Tissue-Specific Contributions of Fructose Metabolism.

Cell Metab 2020 Jul;32(1):6-8

Internal Medicine Research Unit, Pfizer Worldwide Research, Discovery and Medical, Cambridge, MA, USA. Electronic address:

The abundance of dietary sweeteners and overconsumption of fructose are widely thought to promote metabolic disease. In this issue of Cell Metabolism, Andres-Hernando et al. (2020) identify the liver as the major site of fructose metabolism-mediated metabolic dysfunction and identify a surprising role for intestinal fructose metabolism in driving fructose intake. Read More

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http://dx.doi.org/10.1016/j.cmet.2020.06.009DOI Listing

Excessive Astrocytic GABA Causes Cortical Hypometabolism and Impedes Functional Recovery after Subcortical Stroke.

Cell Rep 2020 Jul;32(1):107861

Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, Republic of Korea; Departement of Neurosurgery, Presbyterian Medical Center, Jeonju 54987, Republic of Korea. Electronic address:

Glucose hypometabolism in cortical structures after functional disconnection is frequently reported in patients with white matter diseases such as subcortical stroke. However, the molecular and cellular mechanisms have been poorly elucidated. Here we show, in an animal model of internal capsular infarct, that GABA-synthesizing reactive astrocytes in distant cortical areas cause glucose hypometabolism via tonic inhibition of neighboring neurons. Read More

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http://dx.doi.org/10.1016/j.celrep.2020.107861DOI Listing

Pediatric Dyslipidemia-Beyond Familial Hypercholesterolemia.

Can J Cardiol 2020 Mar 23. Epub 2020 Mar 23.

Departments of Medicine and Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada. Electronic address:

Dyslipidemia is seen with increasing prevalence in young Canadians, mainly mild to moderate hypertriglyceridemia secondary to obesity. This review focuses on pediatric dyslipidemias excluding familial hypercholesterolemia (FH), but including both severe and mild to moderate hypertriglyceridemia, combined hyperlipidemia, and elevated lipoprotein(a) [Lp(a)]. We suggest that for Canadian children and adolescents with dyslipidemia, atherosclerotic cardiovascular disease (ASCVD) risk assessment should include both low-density lipoprotein cholesterol and triglycerides measurement. Read More

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http://dx.doi.org/10.1016/j.cjca.2020.03.020DOI Listing

Illuminating RNA Biology: Tools for Imaging RNA in Live Mammalian Cells.

Cell Chem Biol 2020 Jul 6. Epub 2020 Jul 6.

Department of Biochemistry, BioFrontiers Institute, University of Colorado Boulder, 3415 Colorado Avenue, Boulder, CO 80309, USA. Electronic address:

The central dogma teaches us that DNA makes RNA, which in turn makes proteins, the main building blocks of the cell. But this over simplified linear transmission of information overlooks the vast majority of the genome produces RNAs that do not encode proteins and the myriad ways that RNA regulates cellular functions. Historically, one of the challenges in illuminating RNA biology has been the lack of tools for visualizing RNA in live cells. Read More

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http://dx.doi.org/10.1016/j.chembiol.2020.06.010DOI Listing

Generation of Functional Liver Sinusoidal Endothelial Cells from Human Pluripotent Stem-Cell-Derived Venous Angioblasts.

Cell Stem Cell 2020 Jul 1. Epub 2020 Jul 1.

McEwen Stem Cell Institute, University Health Network, Toronto, ON M5G1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G1L7, Canada. Electronic address:

Liver sinusoidal endothelial cells (LSECs) form a highly specialized microvasculature that plays a critical role in liver function and disease. To better understand this role, we developed a strategy to generate LSECs from human pluripotent stem cells (hPSCs) by first optimizing the specification of arterial and venous angioblasts and derivative endothelial populations. Induction of a LSEC-like fate by hypoxia, cyclic AMP (cAMP) agonism, and transforming growth factor β (TGF-β) inhibition revealed that venous endothelial cells responded more rapidly and robustly than the arterial cells to upregulate LSEC markers and functions in vitro. Read More

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http://dx.doi.org/10.1016/j.stem.2020.06.007DOI Listing

In vivo protective effects of UCMA against cartilage degeneration in monosodium iodoacetate-induced osteoarthritis model.

Can J Physiol Pharmacol 2020 Jul 8. Epub 2020 Jul 8.

Hatay Mustafa Kemal University, Faculty of Medicine, Department of Orthopedics and Traumatology, Hatay, Turkey ;

Osteoarthritis (OA) is a degenerative disease affecting the majority of over 65-year-old people and characterized by cartilage degeneration, subchondral abnormal changes and inflammation. Despite the enormous socioeconomic burden caused by OA, currently, there is no effective therapy against it. Upper Zone of Growth Plate and Cartilage Matrix Associated (UCMA) is a vitamin K-dependent protein and has a critical role in pathophysiological conditions associated with bone and cartilage. Read More

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http://dx.doi.org/10.1139/cjpp-2020-0009DOI Listing

The Speech "Bamana": Using the Syllable Repetition Task to Identify Underlying Phonological Deficits in Children With Speech and Language Impairments.

J Speech Lang Hear Res 2020 Jul 8:1-16. Epub 2020 Jul 8.

Department of Speech, Language, and Hearing Sciences, Purdue University, West Lafayette, IN.

Purpose This study compared performance on the Syllable Repetition Task (SRT) by preschoolers with diverse speech and language abilities to identify underlying impairments in speech processes. Method Three groups of 13 children ages 4 and 5 years with (a) typically developing (TD) speech and language, (b) speech sound disorder (SSD), and (c) comorbid developmental language disorder and speech sound disorder (DLD + SSD) completed the SRT. We calculated competence, memory, encoding, and transcoding scores, as well as word-initial stress pattern and vowel accuracy. Read More

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http://dx.doi.org/10.1044/2020_JSLHR-20-00027DOI Listing

Functional Near-Infrared Spectroscopy in the Study of Speech and Language Impairment Across the Life Span: A Systematic Review.

Am J Speech Lang Pathol 2020 Jul 8:1-28. Epub 2020 Jul 8.

Department of Psychological and Brain Sciences, Boston University, MA.

Purpose Functional brain imaging is playing an increasingly important role in the diagnosis and treatment of communication disorders, yet many populations and settings are incompatible with functional magnetic resonance imaging and other commonly used techniques. We conducted a systematic review of neuroimaging studies using functional near-infrared spectroscopy (fNIRS) with individuals with speech or language impairment across the life span. We aimed to answer the following question: To what extent has fNIRS been used to investigate the neural correlates of speech-language impairment? Method This systematic review was preregistered with PROSPERO, the international prospective register of systematic reviews (CRD42019136464). Read More

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http://dx.doi.org/10.1044/2020_AJSLP-19-00050DOI Listing

Autoimmune Conditions: Rheumatoid Arthritis.

Authors:
Robert C Langan

FP Essent 2020 07;494:11-17

St. Luke's Family Medicine Residency, 2830 Easton Ave, Bethlehem, PA 18017.

Rheumatoid arthritis (RA) is the most common autoimmune inflammatory arthritis, and is seen more commonly in women, smokers, and individuals with a family history of RA. It should be considered if unexplained pain and swelling in the metacarpophalangeal and/or metatarsophalangeal joints and morning stiffness of fingers lasting for longer than 30 minutes are present. RA may be present in the lungs, skin, and eyes. Read More

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The Beginning of Genomic Therapies for ALS.

N Engl J Med 2020 Jul;383(2):180-181

From Trinity College and Beaumont Hospital, Dublin (O.H.); and University Medical Center, Utrecht, the Netherlands (L.H.B.).

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http://dx.doi.org/10.1056/NEJMe2012930DOI Listing

Suppression with Adeno-Associated Virus and MicroRNA in Familial ALS.

N Engl J Med 2020 Jul;383(2):151-158

From the Horae Gene Therapy Center, Department of Pediatrics, University of Massachusetts Medical School (UMMS) (C.M., G.G., M.B., T.R.F.), and the Department of Neurology, UMMS and UMass Memorial Medical Center (D.M.M.-Y., M.A.O., C.L.D., N.S.W., R.H.B.), Worcester, and the Healey Center for ALS, Department of Neurology (J.D.B., L.M.P., D.G., S.D.L., M.P.F., M.E.C.), and the C.S. Kubik Laboratory for Neuropathology (D.H.O., M.P.F.), Massachusetts General Hospital and Harvard Medical School, Boston.

Two patients with familial amyotrophic lateral sclerosis (ALS) and mutations in the gene encoding superoxide dismutase 1 () were treated with a single intrathecal infusion of adeno-associated virus encoding a microRNA targeting SOD1. In Patient 1, SOD1 levels in spinal cord tissue as analyzed on autopsy were lower than corresponding levels in untreated patients with SOD1-mediated ALS and in healthy controls. Levels of SOD1 in cerebrospinal fluid were transiently and only slightly lower in Patient 1 but were not affected in Patient 2. Read More

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http://dx.doi.org/10.1056/NEJMoa2005056DOI Listing

A Randomized Trial of a Multifactorial Strategy to Prevent Serious Fall Injuries.

N Engl J Med 2020 Jul;383(2):129-140

From the Boston Claude D. Pepper Older Americans Independence Center, Research Program in Men's Health: Aging and Metabolism (S. Bhasin, N.K.L., S. Basaria, T.W.S., T.G.T., L.G., B.F.B., R.E.), Brigham and Women's Hospital (S. Bhasin, N.K.L., S. Basaria, P.C.D., T.W.S., T.G.T., P.G., M.B.C., L.G., B.F.B., R.E.), Marcus Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School (T.G.T.), and the University of Massachusetts Boston (P.G.), Boston, and Meyers Primary Care Institute (joint endeavor of Reliant Medical Group, Fallon Health, and University of Massachusetts Medical School), Worcester (J.H.G.); the Yale Claude D. Pepper Older Americans Independence Center (T.M.G., P.C., K.A., J.M.M., E.A.S., D.B.), the Yale Center for Analytical Sciences (E.J.G., J.D., D.E., C.L., H.R., C.M., H.A., P.P.), and the Section of Geriatrics, Department of Internal Medicine, Yale School of Medicine (T.M.G., H.A.), Yale University, New Haven, CT; the Multicampus Program in Geriatric Medicine and Gerontology, David Geffen School of Medicine at UCLA (D.B.R., D.A.G.), the Geriatric Research, Education and Clinical Center, Veterans Affairs Greater Los Angeles Healthcare System (D.A.G.), and the UCLA Claude D. Pepper Older Americans Independence Center (D.B.R, D.A.G.), Los Angeles, and HealthCare Partners, El Segundo (J.R.) - all in California; the School of Nursing, University of Minnesota, Minneapolis (S.M.M.), and Essentia Health, Duluth (S.C.W.) - both in Minnesota; Wake Forest University, School of Medicine, Winston-Salem, NC (M.E.M., P.W.D.); the University of Miami Health System, Miami (M.F.); the Pittsburgh Claude D. Pepper Older Americans Independence Center, Division of Geriatrics and Gerontology, University of Pittsburgh, Pittsburgh (S.L.G., N.M.R.); the University of Michigan, Ann Arbor (N.A., J.W.); Icahn School of Medicine at Mount Sinai, New York (F.K., A.L.S.); the UTMB Claude D. Pepper Older Americans Independence Center, Sealy Center on Aging, University of Texas Medical Branch, Galveston (E.V.); Johns Hopkins University (A.W.W., C.B.) and the University of Maryland School of Medicine (J.M.), Baltimore, and the National Institute on Aging, Bethesda (R.C.-A.) - all in Maryland; and the University of Iowa, Iowa City (R.B.W., C.C.).

Background: Injuries from falls are major contributors to complications and death in older adults. Despite evidence from efficacy trials that many falls can be prevented, rates of falls resulting in injury have not declined.

Methods: We conducted a pragmatic, cluster-randomized trial to evaluate the effectiveness of a multifactorial intervention that included risk assessment and individualized plans, administered by specially trained nurses, to prevent fall injuries. Read More

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http://dx.doi.org/10.1056/NEJMoa2002183DOI Listing

Phase 1-2 Trial of Antisense Oligonucleotide Tofersen for ALS.

N Engl J Med 2020 Jul;383(2):109-119

From the Washington University School of Medicine, St. Louis (T.M., R.C.B., A.P.); the Healey Center for ALS, Massachusetts General Hospital, Harvard Medical School, Boston (M.C., N.A.), and Biogen, Cambridge (A.S., H.R., D.G., H.H., A.M., I.N., I.C., L.F., S.F., T.A.F.) - both in Massachusetts; the Sheffield Institute for Translational Neuroscience, University of Sheffield, and NIHR Sheffield Biomedical Research Centre and Clinical Research Facility, University of Sheffield and Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield (P.J.S., C.J.M.), and Biogen, Maidenhead (M.M.) - both in the United Kingdom; the Department of Clinical Science, Neurosciences, Umeå University, Umea, Sweden (P.M.A.); Montreal Neurological Institute and Hospital, Montreal (A.G.), and Sunnybrook Research Institute, Toronto (L.Z.); Emory University, Atlanta (J.G.); Barrow Neurological Institute, Phoenix, AZ (S.L.); the University of Ulm, Ulm, Germany (A.L.L.); Johns Hopkins University School of Medicine, Baltimore (N.J.M.); the University of California San Diego, La Jolla (J.R.), and Ionis Pharmaceuticals, Carlsbad (C.F.B., R.L.) - both in California; Paris ALS Centre, Hôpital de la Salpêtrière, Paris (F.S.); the University of Tennessee Medical Center, Knoxville (R.T.); and KU Leuven, VIB Center for Brain and Disease Research, University Hospitals Leuven, Leuven, Belgium (P.V.D.).

Background: Tofersen is an antisense oligonucleotide that mediates the degradation of superoxide dismutase 1 (SOD1) messenger RNA to reduce SOD1 protein synthesis. Intrathecal administration of tofersen is being studied for the treatment of amyotrophic lateral sclerosis (ALS) due to mutations.

Methods: We conducted a phase 1-2 ascending-dose trial evaluating tofersen in adults with ALS due to mutations. Read More

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http://dx.doi.org/10.1056/NEJMoa2003715DOI Listing

Ablative fractional CO laser vs lyophilized growth factor intralesional injection vs combination of both modalities for striae distensae treatment.

J Cosmet Dermatol 2020 Jul 8. Epub 2020 Jul 8.

Department of Dermatology, Venereology and Andrology, Ain Shams University, Cairo, Egypt.

Background: Different studies had evaluated the efficacy of fractional CO laser and platelet-rich plasma (PRP) in treating striae distensae (SD). Lyophilized growth factors (LGF) represent another form of delivering growth factors similar to PRP with a more standardized method. To the best of our knowledge, no previous trials have been reported using LGF in SD. Read More

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http://dx.doi.org/10.1111/jocd.13564DOI Listing

B cell signaling pathways - new targets for precision medicine in CLL.

Scand J Immunol 2020 Jul 8:e12931. Epub 2020 Jul 8.

Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.

The B cell receptor (BCR) is a master regulator of B cells, controlling cellular processes such as proliferation, migration and survival. Cell signaling downstream of the BCR is aberrantly activated in the B-cell malignancy chronic lymphocytic leukemia (CLL), supporting the pathophysiology of the disease. This insight has led to development and approval of small molecule inhibitors that target components of the BCR pathway. Read More

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http://dx.doi.org/10.1111/sji.12931DOI Listing

Syringic acid modulates molecular marker-involved cell proliferation, survival, apoptosis, inflammation, and angiogenesis in DMBA-induced oral squamous cell carcinoma in Syrian hamsters.

J Biochem Mol Toxicol 2020 Jul 8:e22574. Epub 2020 Jul 8.

Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar, India.

Despite, different medicinal phyto compounds giving an inexhaustible variety of anticancer drugs, potent signalling mechanism of leads  the key successes of anticancer agent, anti-inflammatory, induction of apoptosis, and antiangiogenic. The current study was conducted to estimate the effect of syringic acid (SA) on tumor necrosis factor-α (TNF-α)-mediated nuclear factor-κB (NF-κB) signaling pathways, inducing apoptosis and angiogenic signaling pathways in a hamster model by preneoplastic stages, histological, immunohistochemistry and immunoblots analysis. Hamsters were given oral cancer by painting 0. Read More

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http://dx.doi.org/10.1002/jbt.22574DOI Listing

Family resources moderate the relationship between seizure control and health-related quality of life in children with drug-resistant epilepsy.

Epilepsia 2020 Jul 8. Epub 2020 Jul 8.

Neurosciences and Mental Health Program, Peter Gilgan Centre for Research and Learning, Hospital for Sick Children, Toronto, Ontario, Canada.

Objective: Pediatric drug-resistant epilepsy (DRE) is associated with poor health-related quality of life (HRQOL). Achieving seizure control, however, does not improve HRQOL in all children. This study sought to evaluate whether (1) baseline caregiver and family factors are associated with child HRQOL at 1-year follow-up over and above epilepsy characteristics, treatment, and seizure outcome; and (2) baseline family factors moderate the association between seizure outcome and child HRQOL at 1-year follow-up. Read More

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http://dx.doi.org/10.1111/epi.16602DOI Listing

A Hybrid In Silico/In Vitro Target Fishing Study to Mine Novel Targets of Urolithin A and B: A Step Towards a Better Comprehension of their Estrogenicity.

Mol Nutr Food Res 2020 Jul 8:e2000289. Epub 2020 Jul 8.

Department of Food and Drug, University of Parma, Parma, 43124, Italy.

Scope: Urolithin A and B are gut metabolites of ellagic acid and ellagitannins associated with many beneficial effects. Evidence in vitro pointed to their potential as estrogenic modulators. However, both molecular mechanisms and biological targets involved in such activity are still poorly characterized, preventing a comprehensive understanding of their bioactivity in living organisms. Read More

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http://dx.doi.org/10.1002/mnfr.202000289DOI Listing

Four-step approach to efficiently develop capillary gel electrophoresis methods for viral vaccine protein analysis.

Electrophoresis 2020 Jul 8. Epub 2020 Jul 8.

Uppsala University, Faculty of Pharmacy, Department of Medicinal Chemistry, Biomedical Centre, PO Box 574, SE-751 23, Uppsala, Sweden.

Vaccines against infectious diseases are urgently needed. Therefore, modern analytical method development should be as efficient as possible to speed up vaccine development. The objectives of the study were to identify critical method parameters (CMPs) and to establish a set of steps to efficiently develop and validate a CE-SDS method for vaccine protein analysis based on a commercially available gel buffer. Read More

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http://dx.doi.org/10.1002/elps.202000107DOI Listing

Giant ankyrin-B suppresses stochastic collateral axon branching through direct interaction with microtubules.

J Cell Biol 2020 Aug;219(8)

Division of Life Science, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.

Giant ankyrin-B (gAnkB) is a 440-kD neurospecific ankyrin-B isoform and a high-confidence target for autism mutations. gAnkB suppresses axon branching through coordination of cortical microtubules, and autism-related mutation of gAnkB results in ectopic neuronal connectivity. We identified a bipartite motif from gAnkB, which bundles and avidly binds to microtubules in vitro. Read More

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http://dx.doi.org/10.1083/jcb.201910053DOI Listing

Expression of NrasQ61R and MYC transgene in germinal center B cells induces a highly malignant multiple myeloma in mice.

Blood 2020 Jul 8. Epub 2020 Jul 8.

Department of Medicine, Division of Blood and Marrow Transplantation, University of California, San Diego, United States.

NRAS Q61 mutations are prevalent in advanced/relapsed multiple myeloma (MM) and correlate with poor patient outcomes. Thus, we generated a novel MM model by conditionally activating expression of endogenous NrasQ61R and a MYC transgene in germinal center B cells (VQ mice). VQ mice developed a highly malignant MM characterized by high proliferation index, hyperactivation of ERK and AKT signaling, impaired hematopoiesis, widespread extramedullary disease, bone lesions, kidney abnormalities, preserved PD1 and TIGIT immune checkpoint pathways, and expression of human high-risk MM gene signatures. Read More

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http://dx.doi.org/10.1182/blood.2020007156DOI Listing

Protection or susceptibility to devastating childhood epilepsy: Nodding Syndrome associates with immunogenetic fingerprints in the HLA binding groove.

PLoS Negl Trop Dis 2020 Jul 8;14(7):e0008436. Epub 2020 Jul 8.

Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, Jerusalem, Israel.

Nodding syndrome (NS) is a devastating and enigmatic childhood epilepsy. NS is accompanied by multiple neurological impairments and neuroinflammation, and associated with the parasite Onchocerca volvulus (Ov) and other environmental factors. Moreover, NS seems to be an 'Autoimmune Epilepsy' since: 1. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008436DOI Listing

Patient preferences for reducing bowel adverse events following prostate radiotherapy.

PLoS One 2020 8;15(7):e0235616. Epub 2020 Jul 8.

Department of Biomedical Informatics, The Ohio State University, Columbus, OH, United States of America.

Background: The Extended Prostate Cancer Index Composite (EPIC) instrument is a commonly used patient reported outcome (PRO) tool in prostate cancer clinical trials. Summary scores for EPIC subscales are calculated by averaging patient scores for attributes (e.g. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235616PLOS

Impact of bone marrow involvement on outcome in relapsed and refractory transplant eligible diffuse large B-cell lymphoma and transformed indolent lymphoma.

PLoS One 2020 8;15(7):e0235786. Epub 2020 Jul 8.

Department of Internal Medicine IV, Haematology and Oncology, University Hospital Halle (Saale), Martin-Luther-University Halle-Wittenberg, Halle, Germany.

In front-line treatment of diffuse large B-cell lymphoma (DLBCL), prior studies suggest that concordant but not discordant involvement of the bone marrow (BM) portends a poor prognosis. The prognostic impact of bone marrow infiltration (BMI) in recurrent or refractory DLBCL (r/rDLBCL) and transformed indolent lymphoma (r/rTRIL) patients is less clear. Thus, we examined the prognostic significance of the infiltration of bone marrow (BMI) by concordant, large B-cells (conBMI) and discordant, small B-cells (disBMI) in this patient group. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235786PLOS

Using trauma registry data to predict prolonged mechanical ventilation in patients with traumatic brain injury: Machine learning approach.

PLoS One 2020 8;15(7):e0235231. Epub 2020 Jul 8.

Department of Surgery, Trauma Surgery, Clinical Research, Hamad Medical Corporation, Doha, Qatar.

Objectives: We aimed to build a machine learning predictive model to predict the risk of prolonged mechanical ventilation (PMV) for patients with Traumatic Brain Injury (TBI).

Methods: This study included TBI patients who were hospitalized in a level 1 trauma center between January 2014 and February 2019. Data were analyzed for all adult patients who received mechanical ventilation following TBI with abbreviated injury severity (AIS) score for the head region of ≥ 3. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235231PLOS

Plasmodium vivax AMA1: Implications of distinct haplotypes for immune response.

PLoS Negl Trop Dis 2020 Jul 8;14(7):e0008471. Epub 2020 Jul 8.

Instituto Carlos Chagas, Fundação Oswaldo Cruz-FIOCRUZ. Curitiba, PR, Brazil.

In Brazil, Plasmodium vivax infection accounts for around 80% of malaria cases. This infection has a substantial impact on the productivity of the local population as the course of the disease is usually prolonged and the development of acquired immunity in endemic areas takes several years. The recent emergence of drug-resistant strains has intensified research on alternative control methods such as vaccines. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008471DOI Listing

Comparison of the Posterior and Anterolateral Surgical Approaches in the Treatment of Humeral Mid-Shaft Fractures: A Retrospective Study.

Med Sci Monit 2020 Jul 8;26:e924400. Epub 2020 Jul 8.

Orthopedic Department, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China (mainland).

BACKGROUND The aim of this study was to retrospectively assess and compare the functional outcomes and complications following anterolateral versus posterior surgical approaches for the treatment of mid-shaft fractures of the humerus. MATERIAL AND METHODS This study included 107 patients treated for mid-shaft fractures between May 2015 and July 2018. Demographic and surgical data were collected for each patient. Read More

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http://dx.doi.org/10.12659/MSM.924400DOI Listing

A Survey of Iranian Primiparous Women's Perceptions of Vaginal Examination During Labor.

J Prim Care Community Health 2020 Jan-Dec;11:2150132720940517

Coventry University, Coventry, UK.

To assess perceptions about vaginal examinations (VEs) during labor among women referred to the Akbarabadi Hospital in Tehran, Iran. This was a cross-sectional study conducted from December 2015 to May 2016. It included 200 primiparous women. Read More

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http://dx.doi.org/10.1177/2150132720940517DOI Listing

Cardiovascular End Points and Mortality Are Not Closer Associated With Central Than Peripheral Pulsatile Blood Pressure Components.

Hypertension 2020 Aug 8;76(2):350-358. Epub 2020 Jul 8.

Research Unit Hypertension and Cardiovascular Epidemiology (L.T., F.-F.W., J.D.M., Z.-Y.Z., J.A.S.), KU Leuven Department of Cardiovascular Sciences, University of Leuven, Belgium.

Pulsatile blood pressure (BP) confers cardiovascular risk. Whether associations of cardiovascular end points are tighter for central systolic BP (cSBP) than peripheral systolic BP (pSBP) or central pulse pressure (cPP) than peripheral pulse pressure (pPP) is uncertain. Among 5608 participants (54. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.120.14787DOI Listing

Pregnancy-Related Complications in Patients With Fibromuscular Dysplasia: A Report From the European/International Fibromuscular Dysplasia Registry.

Hypertension 2020 Aug 8;76(2):545-553. Epub 2020 Jul 8.

Division of Cardiology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium (M.P., S.D.M., A. Pasquet, A. Persu).

Current literature suggests a higher risk of pregnancy-related complications in patients with renal fibromuscular dysplasia (FMD). The aim of our study was to assess the nature and prevalence of pregnancy-related complications in patients subsequently diagnosed with FMD. A call for participation was sent to centers contributing to the European/International FMD Registry. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.120.15349DOI Listing

Association of Markers of Microvascular Dysfunction With Prevalent and Incident Depressive Symptoms: The Maastricht Study.

Hypertension 2020 Aug 8;76(2):342-349. Epub 2020 Jul 8.

Department of Internal Medicine (A.F.J.G., M.J.M.v.A., C.D.A.S., B.M.S., N.C.S., R.M.A.H., C.J.H.v.d.K., T.T.v.S., M.T.S., A.J.H.M.H.), Maastricht University Medical Center (MUMC+), the Netherlands.

The etiology of late-life depression (LLD) is still poorly understood. Microvascular dysfunction (MVD) has been suggested to play a role in the etiology of LLD, but direct evidence of this association is scarce. The aim of this study was to investigate whether direct and indirect markers of early microvascular dysfunction are associated with prevalent and incident LLD in the population-based Maastricht Study cohort. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.120.15260DOI Listing

Polydrug Use and Dating Violence Among Emerging Adults.

J Interpers Violence 2020 Jul 8:886260520934427. Epub 2020 Jul 8.

The University of Texas Medical Branch at Galveston, USA.

We examined sociodemographic and psychosocial risk factors that moderate the (poly) substance use and dating violence victimization and perpetration relationship among emerging adults. Using an ethnically diverse sample ( = 698), we used latent class analyses to identify mutually exclusive groups based on monthly and past-year substance use. We then examined these groups as they relate to dating violence victimization and perpetration and the moderating effect of various risk factors. Read More

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http://dx.doi.org/10.1177/0886260520934427DOI Listing

Measurements of Absolute Branching Fractions of Fourteen Exclusive Hadronic D Decays to η.

Authors:
M Ablikim M N Achasov P Adlarson S Ahmed M Albrecht A Amoroso Q An Anita X H Bai Y Bai O Bakina R Baldini Ferroli I Balossino Y Ban K Begzsuren J V Bennett N Berger M Bertani D Bettoni F Bianchi J Biernat J Bloms A Bortone I Boyko R A Briere H Cai X Cai A Calcaterra G F Cao N Cao S A Cetin J F Chang W L Chang G Chelkov D Y Chen G Chen H S Chen M L Chen S J Chen X R Chen Y B Chen W S Cheng G Cibinetto F Cossio X F Cui H L Dai J P Dai X C Dai A Dbeyssi R B de Boer D Dedovich Z Y Deng A Denig I Denysenko M Destefanis F De Mori Y Ding C Dong J Dong L Y Dong M Y Dong S X Du J Fang S S Fang Y Fang R Farinelli L Fava F Feldbauer G Felici C Q Feng M Fritsch C D Fu Y Fu X L Gao Y Gao Y Gao Y G Gao I Garzia E M Gersabeck A Gilman K Goetzen L Gong W X Gong W Gradl M Greco L M Gu M H Gu S Gu Y T Gu C Y Guan A Q Guo L B Guo R P Guo Y P Guo Y P Guo A Guskov S Han T T Han T Z Han X Q Hao F A Harris K L He F H Heinsius T Held Y K Heng M Himmelreich T Holtmann Y R Hou Z L Hou H M Hu J F Hu T Hu Y Hu G S Huang L Q Huang X T Huang Y P Huang Z Huang N Huesken T Hussain W Ikegami Andersson W Imoehl M Irshad S Jaeger S Janchiv Q Ji Q P Ji X B Ji X L Ji H B Jiang X S Jiang X Y Jiang J B Jiao Z Jiao S Jin Y Jin T Johansson N Kalantar-Nayestanaki X S Kang R Kappert M Kavatsyuk B C Ke I K Keshk A Khoukaz P Kiese R Kiuchi R Kliemt L Koch O B Kolcu B Kopf M Kuemmel M Kuessner A Kupsc M G Kurth W Kühn J J Lane J S Lange P Larin L Lavezzi H Leithoff M Lellmann T Lenz C Li C H Li Cheng Li D M Li F Li G Li H B Li H J Li J L Li J Q Li Ke Li L K Li Lei Li P L Li P R Li S Y Li W D Li W G Li X H Li X L Li Z B Li Z Y Li H Liang H Liang Y F Liang Y T Liang L Z Liao J Libby C X Lin B Liu B J Liu C X Liu D Liu D Y Liu F H Liu Fang Liu Feng Liu H B Liu H M Liu Huanhuan Liu Huihui Liu J B Liu J Y Liu K Liu K Y Liu Ke Liu L Liu Q Liu S B Liu Shuai Liu T Liu X Liu Y B Liu Z A Liu Z Q Liu Y F Long X C Lou F X Lu H J Lu J D Lu J G Lu X L Lu Y Lu Y P Lu C L Luo M X Luo P W Luo T Luo X L Luo S Lusso X R Lyu F C Ma H L Ma L L Ma M M Ma Q M Ma R Q Ma R T Ma X N Ma X X Ma X Y Ma Y M Ma F E Maas M Maggiora S Maldaner S Malde Q A Malik A Mangoni Y J Mao Z P Mao S Marcello Z X Meng J G Messchendorp G Mezzadri T J Min R E Mitchell X H Mo Y J Mo N Yu Muchnoi H Muramatsu S Nakhoul Y Nefedov F Nerling I B Nikolaev Z Ning S Nisar S L Olsen Q Ouyang S Pacetti X Pan Y Pan A Pathak P Patteri M Pelizaeus H P Peng K Peters J Pettersson J L Ping R G Ping A Pitka R Poling V Prasad H Qi H R Qi M Qi T Y Qi T Y Qi S Qian W-B Qian Z Qian C F Qiao L Q Qin X P Qin X S Qin Z H Qin J F Qiu S Q Qu K H Rashid K Ravindran C F Redmer A Rivetti V Rodin M Rolo G Rong Ch Rosner M Rump A Sarantsev Y Schelhaas C Schnier K Schoenning D C Shan W Shan X Y Shan M Shao C P Shen P X Shen X Y Shen H C Shi R S Shi X Shi X D Shi J J Song Q Q Song W M Song Y X Song S Sosio S Spataro F F Sui G X Sun J F Sun L Sun S S Sun T Sun W Y Sun Y J Sun Y K Sun Y Z Sun Z T Sun Y H Tan Y X Tan C J Tang G Y Tang J Tang V Thoren B Tsednee I Uman B Wang B L Wang C W Wang D Y Wang H P Wang K Wang L L Wang M Wang M Z Wang Meng Wang W H Wang W P Wang X Wang X F Wang X L Wang Y Wang Y Wang Y D Wang Y F Wang Y Q Wang Z Wang Z Y Wang Ziyi Wang Zongyuan Wang D H Wei P Weidenkaff F Weidner S P Wen D J White U Wiedner G Wilkinson M Wolke L Wollenberg J F Wu L H Wu L J Wu X Wu Z Wu L Xia H Xiao S Y Xiao Y J Xiao Z J Xiao X H Xie Y G Xie Y H Xie T Y Xing X A Xiong G F Xu J J Xu Q J Xu W Xu X P Xu F Yan L Yan L Yan W B Yan W C Yan Xu Yan H J Yang H X Yang L Yang R X Yang S L Yang Y H Yang Y X Yang Yifan Yang Zhi Yang M Ye M H Ye J H Yin Z Y You B X Yu C X Yu G Yu J S Yu T Yu C Z Yuan W Yuan X Q Yuan Y Yuan Z Y Yuan C X Yue A Yuncu A A Zafar Y Zeng B X Zhang Guangyi Zhang H H Zhang H Y Zhang J L Zhang J Q Zhang J W Zhang J Y Zhang J Z Zhang Jianyu Zhang Jiawei Zhang L Zhang Lei Zhang S Zhang S F Zhang T J Zhang X Y Zhang Y Zhang Y H Zhang Y T Zhang Yan Zhang Yao Zhang Yi Zhang Z H Zhang Z Y Zhang G Zhao J Zhao J Y Zhao J Z Zhao Lei Zhao Ling Zhao M G Zhao Q Zhao S J Zhao Y B Zhao Y X Zhao Z G Zhao A Zhemchugov B Zheng J P Zheng Y Zheng Y H Zheng B Zhong C Zhong L P Zhou Q Zhou X Zhou X K Zhou X R Zhou A N Zhu J Zhu K Zhu K J Zhu S H Zhu W J Zhu X L Zhu Y C Zhu Z A Zhu B S Zou J H Zou

Phys Rev Lett 2020 Jun;124(24):241803

Institute of High Energy Physics, Beijing 100049, People's Republic of China.

Using 2.93  fb^{-1} of e^{+}e^{-} collision data taken at a center-of-mass energy of 3.773 GeV with the BESIII detector, we report the first measurements of the absolute branching fractions of 14 hadronic D^{0(+)} decays to exclusive final states with an η, e. Read More

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http://dx.doi.org/10.1103/PhysRevLett.124.241803DOI Listing

Study of Open-Charm Decays and Radiative Transitions of the X(3872).

Authors:
M Ablikim M N Achasov P Adlarson S Ahmed M Albrecht A Amoroso Q An Anita Y Bai O Bakina R Baldini Ferroli I Balossino Y Ban K Begzsuren J V Bennett N Berger M Bertani D Bettoni F Bianchi J Biernat J Bloms A Bortone I Boyko R A Briere H Cai X Cai A Calcaterra G F Cao N Cao S A Cetin J F Chang W L Chang G Chelkov D Y Chen G Chen H S Chen M L Chen S J Chen X R Chen Y B Chen W Cheng G Cibinetto F Cossio X F Cui H L Dai J P Dai X C Dai A Dbeyssi R B de Boer D Dedovich Z Y Deng A Denig I Denysenko M Destefanis F De Mori Y Ding C Dong J Dong L Y Dong M Y Dong S X Du J Fang S S Fang Y Fang R Farinelli L Fava F Feldbauer G Felici C Q Feng M Fritsch C D Fu Y Fu X L Gao Y Gao Y Gao Y G Gao I Garzia E M Gersabeck A Gilman K Goetzen L Gong W X Gong W Gradl M Greco L M Gu M H Gu S Gu Y T Gu C Y Guan A Q Guo L B Guo R P Guo Y P Guo A Guskov S Han T T Han T Z Han X Q Hao F A Harris K L He F H Heinsius T Held Y K Heng M Himmelreich T Holtmann Y R Hou Z L Hou H M Hu J F Hu T Hu Y Hu G S Huang L Q Huang X T Huang N Huesken T Hussain W Ikegami Andersson W Imoehl M Irshad S Jaeger S Janchiv Q Ji Q P Ji X B Ji X L Ji H B Jiang X S Jiang X Y Jiang J B Jiao Z Jiao S Jin Y Jin T Johansson N Kalantar-Nayestanaki X S Kang R Kappert M Kavatsyuk B C Ke I K Keshk A Khoukaz P Kiese R Kiuchi R Kliemt L Koch O B Kolcu B Kopf M Kuemmel M Kuessner A Kupsc M G Kurth W Kühn J J Lane J S Lange P Larin L Lavezzi H Leithoff M Lellmann T Lenz C Li C H Li Cheng Li D M Li F Li G Li H B Li H J Li J L Li J Q Li Ke Li L K Li Lei Li P L Li P R Li W D Li W G Li X H Li X L Li Z B Li Z Y Li H Liang H Liang Y F Liang Y T Liang L Z Liao J Libby C X Lin B Liu B J Liu C X Liu D Liu D Y Liu F H Liu Fang Liu Feng Liu H B Liu H M Liu Huanhuan Liu Huihui Liu J B Liu J Y Liu K Liu K Y Liu Ke Liu L Liu L Y Liu Q Liu S B Liu T Liu X Liu Y B Liu Z A Liu Z Q Liu Y F Long X C Lou H J Lu J D Lu J G Lu X L Lu Y Lu Y P Lu C L Luo M X Luo P W Luo T Luo X L Luo S Lusso X R Lyu F C Ma H L Ma L L Ma M M Ma Q M Ma R Q Ma R T Ma X N Ma X X Ma X Y Ma Y M Ma F E Maas M Maggiora S Maldaner S Malde Q A Malik A Mangoni Y J Mao Z P Mao S Marcello Z X Meng J G Messchendorp G Mezzadri T J Min R E Mitchell X H Mo Y J Mo N Yu Muchnoi H Muramatsu S Nakhoul Y Nefedov F Nerling I B Nikolaev Z Ning S Nisar S L Olsen Q Ouyang S Pacetti Y Pan Y Pan M Papenbrock A Pathak P Patteri M Pelizaeus H P Peng K Peters J Pettersson J L Ping R G Ping A Pitka R Poling V Prasad H Qi M Qi T Y Qi S Qian W-B Qian C F Qiao L Q Qin X P Qin X S Qin Z H Qin J F Qiu S Q Qu K H Rashid K Ravindran C F Redmer A Rivetti V Rodin M Rolo G Rong Ch Rosner M Rump A Sarantsev M Savrié Y Schelhaas C Schnier K Schoenning W Shan X Y Shan M Shao C P Shen P X Shen X Y Shen H C Shi R S Shi X Shi X D Shi J J Song Q Q Song Y X Song S Sosio S Spataro F F Sui G X Sun J F Sun L Sun S S Sun T Sun W Y Sun Y J Sun Y K Sun Y Z Sun Z T Sun Y X Tan C J Tang G Y Tang V Thoren B Tsednee I Uman B Wang B L Wang C W Wang D Y Wang H P Wang K Wang L L Wang M Wang M Z Wang Meng Wang W P Wang X Wang X F Wang X L Wang Y Wang Y Wang Y D Wang Y F Wang Y Q Wang Z Wang Z Y Wang Ziyi Wang Zongyuan Wang T Weber D H Wei P Weidenkaff F Weidner H W Wen S P Wen D J White U Wiedner G Wilkinson M Wolke L Wollenberg J F Wu L H Wu L J Wu X Wu Z Wu L Xia H Xiao S Y Xiao Y J Xiao Z J Xiao Y G Xie Y H Xie T Y Xing X A Xiong G F Xu J J Xu Q J Xu W Xu X P Xu L Yan W B Yan W C Yan W C Yan H J Yang H X Yang L Yang R X Yang S L Yang Y H Yang Y X Yang Yifan Yang Zhi Yang M Ye M H Ye J H Yin Z Y You B X Yu C X Yu G Yu J S Yu T Yu C Z Yuan W Yuan X Q Yuan Y Yuan C X Yue A Yuncu A A Zafar Y Zeng B X Zhang Guangyi Zhang H H Zhang H Y Zhang J L Zhang J Q Zhang J W Zhang J Y Zhang J Z Zhang Jianyu Zhang Jiawei Zhang L Zhang Lei Zhang S Zhang S F Zhang T J Zhang X Y Zhang Y Zhang Y H Zhang Y T Zhang Yan Zhang Yao Zhang Yi Zhang Z H Zhang Z Y Zhang G Zhao J Zhao J Y Zhao J Z Zhao Lei Zhao Ling Zhao M G Zhao Q Zhao S J Zhao Y B Zhao Y X Zhao Zhao Z G Zhao A Zhemchugov B Zheng J P Zheng Y Zheng Y H Zheng B Zhong C Zhong L P Zhou Q Zhou X Zhou X K Zhou X R Zhou A N Zhu J Zhu K Zhu K J Zhu S H Zhu W J Zhu X L Zhu Y C Zhu Z A Zhu B S Zou J H Zou

Phys Rev Lett 2020 Jun;124(24):242001

Institute of High Energy Physics, Beijing 100049, People's Republic of China.

The processes X(3872)→D^{*0}D[over ¯]^{0}+c.c.,γJ/ψ,γψ(2S), and γD^{+}D^{-} are searched for in a 9. Read More

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http://dx.doi.org/10.1103/PhysRevLett.124.242001DOI Listing

Stealth Entropy Production in Active Field Theories near Ising Critical Points.

Phys Rev Lett 2020 Jun;124(24):240604

DAMTP, Centre for Mathematical Sciences, University of Cambridge, Wilberforce Road, Cambridge CB3 0WA, United Kingdom.

We address the steady-state entropy production rate (EPR) of active scalar ϕ^{4} theories, which lack time-reversal symmetry, close to a phase-separation critical point. We consider both nonconserved (model A) and conserved (model B) dynamics at Gaussian level, and also address the former at leading order in ε=4-d. In each case, activity is irrelevant in the RG sense: the active model lies in the same (dynamic Ising) universality class as its time-reversible counterpart. Read More

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http://dx.doi.org/10.1103/PhysRevLett.124.240604DOI Listing

Determination of Strong-Phase Parameters in D→K_{S,L}^{0}π^{+}π^{-}.

Authors:
M Ablikim M N Achasov P Adlarson S Ahmed M Albrecht M Alekseev D Ambrose A Amoroso F F An Q An Anita Y Bai O Bakina R Baldini Ferroli I Balossino Y Ban K Begzsuren J V Bennett N Berger M Bertani D Bettoni F Bianchi J Biernat J Bloms I Boyko R A Briere H Cai X Cai A Calcaterra G F Cao N Cao S A Cetin J Chai J F Chang W L Chang G Chelkov D Y Chen G Chen H S Chen J Chen J C Chen M L Chen S J Chen Y B Chen W Cheng G Cibinetto F Cossio X F Cui H L Dai J P Dai X C Dai A Dbeyssi D Dedovich Z Y Deng A Denig I Denysenko M Destefanis F De Mori Y Ding C Dong J Dong L Y Dong M Y Dong Z L Dou S X Du J Z Fan J Fang S S Fang Y Fang R Farinelli L Fava F Feldbauer G Felici C Q Feng M Fritsch C D Fu Y Fu Q Gao X L Gao Y Gao Y Gao Y G Gao Z Gao B Garillon I Garzia E M Gersabeck A Gilman K Goetzen L Gong W X Gong W Gradl M Greco L M Gu M H Gu S Gu Y T Gu A Q Guo L B Guo R P Guo Y P Guo A Guskov S Han X Q Hao F A Harris K L He F H Heinsius T Held Y K Heng M Himmelreich Y R Hou Z L Hou H M Hu J F Hu T Hu Y Hu G S Huang J S Huang X T Huang X Z Huang N Huesken T Hussain W Ikegami Andersson W Imoehl M Irshad Q Ji Q P Ji X B Ji X L Ji H L Jiang X S Jiang X Y Jiang J B Jiao Z Jiao D P Jin S Jin Y Jin T Johansson N Kalantar-Nayestanaki X S Kang R Kappert M Kavatsyuk B C Ke I K Keshk A Khoukaz P Kiese R Kiuchi R Kliemt L Koch O B Kolcu B Kopf M Kuemmel M Kuessner A Kupsc M Kurth M G Kurth W Kühn J S Lange P Larin L Lavezzi H Leithoff T Lenz C Li Cheng Li D M Li F Li F Y Li G Li H B Li H J Li J C Li J W Li Ke Li L K Li Lei Li P L Li P R Li Q Y Li W D Li W G Li X H Li X L Li X N Li Z B Li Z Y Li H Liang H Liang Y F Liang Y T Liang G R Liao L Z Liao J Libby C X Lin D X Lin Y J Lin B Liu B J Liu C X Liu D Liu D Y Liu F H Liu Fang Liu Feng Liu H B Liu H M Liu Huanhuan Liu Huihui Liu J B Liu J Y Liu K Liu K Y Liu Ke Liu L Y Liu Q Liu S B Liu T Liu X Liu X Y Liu Y B Liu Z A Liu Zhiqing Liu Y F Long X C Lou H J Lu J D Lu J G Lu Y Lu Y P Lu C L Luo M X Luo P W Luo T Luo X L Luo S Lusso X R Lyu F C Ma H L Ma L L Ma M M Ma Q M Ma X N Ma X X Ma X Y Ma Y M Ma F E Maas M Maggiora S Maldaner S Malde Q A Malik A Mangoni Y J Mao Z P Mao S Marcello Z X Meng J G Messchendorp G Mezzadri J Min T J Min R E Mitchell X H Mo Y J Mo C Morales Morales N Yu Muchnoi H Muramatsu A Mustafa S Nakhoul Y Nefedov F Nerling I B Nikolaev Z Ning S Nisar S L Niu S L Olsen Q Ouyang S Pacetti Y Pan M Papenbrock P Patteri M Pelizaeus H P Peng K Peters J Pettersson J L Ping R G Ping A Pitka R Poling V Prasad H R Qi M Qi T Y Qi S Qian C F Qiao N Qin X P Qin X S Qin Z H Qin J F Qiu S Q Qu K H Rashid K Ravindran C F Redmer M Richter A Rivetti V Rodin M Rolo G Rong Ch Rosner M Rump A Sarantsev M Savrié Y Schelhaas K Schoenning W Shan X Y Shan M Shao C P Shen P X Shen X Y Shen H Y Sheng X Shi X D Shi J J Song Q Q Song X Y Song S Sosio C Sowa S Spataro F F Sui G X Sun J F Sun L Sun S S Sun X H Sun Y J Sun Y K Sun Y Z Sun Z J Sun Z T Sun Y T Tan C J Tang G Y Tang X Tang V Thoren B Tsednee I Uman B Wang B L Wang C W Wang D Y Wang K Wang L L Wang L S Wang M Wang M Z Wang Meng Wang P L Wang R M Wang W P Wang X Wang X F Wang X L Wang Y Wang Y Wang Y F Wang Y Q Wang Z Wang Z G Wang Z Y Wang Zongyuan Wang T Weber D H Wei P Weidenkaff H W Wen S P Wen U Wiedner G Wilkinson M Wolke L H Wu L J Wu Z Wu L Xia Y Xia S Y Xiao Y J Xiao Z J Xiao Y G Xie Y H Xie T Y Xing X A Xiong Q L Xiu G F Xu J J Xu L Xu Q J Xu W Xu X P Xu F Yan L Yan W B Yan W C Yan Y H Yan H J Yang H X Yang L Yang R X Yang S L Yang Y H Yang Y X Yang Yifan Yang Z Q Yang M Ye M H Ye J H Yin Z Y You B X Yu C X Yu J S Yu T Yu C Z Yuan X Q Yuan Y Yuan A Yuncu A A Zafar Y Zeng B X Zhang B Y Zhang C C Zhang D H Zhang H H Zhang H Y Zhang J Zhang J L Zhang J Q Zhang J W Zhang J Y Zhang J Z Zhang K Zhang L Zhang L Zhang S F Zhang T J Zhang X Y Zhang Y Zhang Y H Zhang Y T Zhang Yang Zhang Yao Zhang Yi Zhang Yu Zhang Z H Zhang Z P Zhang Z Y Zhang G Zhao J W Zhao J Y Zhao J Z Zhao Lei Zhao Ling Zhao M G Zhao Q Zhao S J Zhao T C Zhao Y B Zhao Z G Zhao A Zhemchugov B Zheng J P Zheng Y Zheng Y H Zheng B Zhong L Zhou L P Zhou Q Zhou X Zhou X K Zhou X R Zhou Xiaoyu Zhou Xu Zhou A N Zhu J Zhu J Zhu K Zhu K J Zhu S H Zhu W J Zhu X L Zhu Y C Zhu Y S Zhu Z A Zhu J Zhuang B S Zou J H Zou

Phys Rev Lett 2020 Jun;124(24):241802

Institute of High Energy Physics, Beijing 100049, People's Republic of China.

We report the most precise measurements to date of the strong-phase parameters between D^{0} and D[over ¯]^{0} decays to K_{S,L}^{0}π^{+}π^{-} using a sample of 2.93  fb^{-1} of e^{+}e^{-} annihilation data collected at a center-of-mass energy of 3.773 GeV with the BESIII detector at the BEPCII collider. Read More

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http://dx.doi.org/10.1103/PhysRevLett.124.241802DOI Listing

Colossal Pressure-Induced Softening in Scandium Fluoride.

Phys Rev Lett 2020 Jun;124(25):255502

College of Computer Science, Sichuan University, Chengdu, Sichuan 610065, People's Republic of China.

The counterintuitive phenomenon of pressure-induced softening in materials is likely to be caused by the same dynamical behavior that produces negative thermal expansion. Through a combination of molecular dynamics simulation on an idealized model and neutron diffraction at variable temperature and pressure, we show the existence of extraordinary and unprecedented pressure-induced softening in the negative thermal expansion material scandium fluoride ScF_{3}. The pressure derivative of the bulk modulus B, B^{'}=(∂B/∂P)_{P=0}, reaches values as low as -220±30 at 50 K, and is constant at -50 between 150 and 250 K. Read More

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http://dx.doi.org/10.1103/PhysRevLett.124.255502DOI Listing

Predictions for the Cosmic Microwave Background from an Anisotropic Quantum Bounce.

Phys Rev Lett 2020 Jun;124(25):251301

Department of Physics, National Institute of Technology Karnataka, Surathkal, Mangalore 575025, India.

We introduce an extension of the standard inflationary paradigm on which the big bang singularity is replaced by an anisotropic bounce. Unlike in the big bang model, cosmological perturbations find an adiabatic regime in the past. We show that this scenario accounts for the observed quadrupolar modulation in the temperature anisotropies of the cosmic microwave background, and we make predictions for the polarization angular correlation functions E-E, B-B, and E-B, together with temperature-polarization correlations T-B and T-E, that can be used to test our ideas. Read More

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http://dx.doi.org/10.1103/PhysRevLett.124.251301DOI Listing

Candidate Electromagnetic Counterpart to the Binary Black Hole Merger Gravitational-Wave Event S190521g.

Phys Rev Lett 2020 Jun;124(25):251102

Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, California 94720, USA.

We report the first plausible optical electromagnetic counterpart to a (candidate) binary black hole merger. Detected by the Zwicky Transient Facility, the electromagnetic flare is consistent with expectations for a kicked binary black hole merger in the accretion disk of an active galactic nucleus [B. McKernan, K. Read More

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http://dx.doi.org/10.1103/PhysRevLett.124.251102DOI Listing

Rare A-Type, Spiro-Type, and Highly Oligomeric Proanthocyanidins from .

Org Lett 2020 Jul 8. Epub 2020 Jul 8.

Department of Pharmaceutical Sciences (PSCI), College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States.

An investigation of the dental bioactive proanthocyanidin (PAC) oligomer fractions led to three structurally distinct new PACs (-) from pine bark. Pinutwindoublin () is the first reported trimer with double A-type interflavanyl linkages (2α→O→5,4α→6 and 2α→O→7,4α→8). Pinuspirotetrin () represents the first reported PAC tetramer with a heterodimeric framework consisting of one spiro-type and one A-type dimer. Read More

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http://dx.doi.org/10.1021/acs.orglett.0c01439DOI Listing

An Integrated Approach for Characterizing Bispecific Antibody/Antigens Complexes and Mapping Binding Epitopes with SEC/MALS, Native Mass Spectrometry and Protein Footprinting.

Anal Chem 2020 Jul 8. Epub 2020 Jul 8.

Bispecific antibodies (BsAbs), with a unique mechanism of recognizing two different epitopes or antigens, have shown potential in various therapeutic areas. Molecular characterization of BsAbs' epitopes not only allows detailed understanding of their mechanism of actions, but also guides the design and selection of drug candidate molecules. In this study, we illustrate the practical utility of an integrated approach, including size exclusion chromatography with multi-angle light scattering and native mass spectrometry (MS), for the biophysical characterization of complex formation of a BsAb with two target antigens, cluster of differentiation 3 (CD3) and B-cell maturation antigen (BCMA). Read More

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http://dx.doi.org/10.1021/acs.analchem.0c01876DOI Listing

Immunoglobulin profile and B-cell frequencies are altered with changes in the cellular microenvironment independent of the stimulation conditions.

Immun Inflamm Dis 2020 Jul 8. Epub 2020 Jul 8.

Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.

Introduction: B-cells are essential in the defense against Mycobacterium tuberculosis. Studies on isolated cells may not accurately reflect the responses that occur in vivo due to the presence of other cells. This study elucidated the influence of microenvironment complexity on B-cell polarization and function in the context of tuberculosis disease. Read More

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http://dx.doi.org/10.1002/iid3.328DOI Listing

Parallel transmission medical implant safety testbed: Real-time mitigation of RF induced tip heating using time-domain E-field sensors.

Magn Reson Med 2020 Jul 8. Epub 2020 Jul 8.

Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany.

Purpose: To implement a modular, flexible, open-source hardware configuration for parallel transmission (pTx) experiments on medical implant safety and to demonstrate real-time mitigation strategies for radio frequency (RF) induced implant heating based on sensor measurements.

Methods: The hardware comprises a home-built 8-channel pTx system (scalable to 32-channels), wideband power amplifiers and a positioning system with submillimeter precision. The orthogonal projection (OP) method is used to mitigate RF induced tip heating and to maintain sufficient for imaging. Read More

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http://dx.doi.org/10.1002/mrm.28379DOI Listing
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