2,743 results match your criteria Azotemia


Clinicopathologic and pathologic characteristics of feline proteinuric kidney disease.

J Feline Med Surg 2020 May 27:1098612X20921056. Epub 2020 May 27.

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.

Objectives: The aim of this study was to describe the causes, clinicopathologic features and outcomes of feline protein-losing nephropathy (proteinuria secondary to glomerular disease [PLN]).

Methods: Kidney biopsy/necropsy samples from proteinuric cats submitted to the International Veterinary Renal Pathology Service were retrospectively reviewed. Diagnoses based on histopathology were categorized by primary disease compartment. Read More

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http://dx.doi.org/10.1177/1098612X20921056DOI Listing

Acute on chronic kidney disease in cats: Etiology, clinical and clinicopathologic findings, prognostic markers, and outcome.

J Vet Intern Med 2020 May 22. Epub 2020 May 22.

Veterinary Teaching Hospital, Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel.

Background: Chronic kidney disease (CKD) and acute decompensation of CKD (ACKD) are common in cats.

Objectives: To characterize the etiology, clinical and clinicopathologic findings, and the short- and long-term prognosis of feline ACKD.

Animals: One hundred cats with ACKD. Read More

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http://dx.doi.org/10.1111/jvim.15808DOI Listing

Dehydroascorbic acid, the oxidized form of vitamin C, improves renal histology and function in old mice.

J Cell Physiol 2020 May 21. Epub 2020 May 21.

Center for Advanced Microscopy CMA BIO BIO, University of Concepcion, Concepcion, Chile.

Oxidative stress and inflammation are crucial factors that increase with age. In the progression of multiple age-related diseases, antioxidants and bioactive compounds have been recognized as useful antiaging agents. Oxidized or reduced vitamin C exerts different actions on tissues and has different metabolism and uptake. Read More

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http://dx.doi.org/10.1002/jcp.29791DOI Listing

Uremia Preventing Osmotic Demyelination Syndrome Despite Rapid Hyponatremia Correction.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620918095

Morehouse School of Medicine, Atlanta, GA, USA.

Hyponatremia is the most common electrolyte abnormality encountered both in the inpatient and outpatient clinical settings in the United States. Rapid correction leads to a deranged cerebral osmotic gradient causing osmotic demyelination syndrome. Coexisting azotemia is considered to be protective against osmotic demyelination syndrome owing to its counteractive effect on osmolarity change that occurs with rapid hyponatremia correction. Read More

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http://dx.doi.org/10.1177/2324709620918095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232043PMC

Acute Kidney Injury Associated with Minimal Change Nephrotic Syndrome in an Elderly Patient Successfully Treated with both Fluid Management and Specific Therapy Based on Kidney Biopsy Findings.

Case Rep Nephrol Dial 2020 Jan-Apr;10(1):42-50. Epub 2020 Apr 22.

Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Oliguric acute kidney injury (AKI) with minimal change nephrotic syndrome (MCNS) has long been recognized. Several mechanisms such as hypovolemia due to hypoalbuminemia and the nephrosarca hypothesis have been proposed. However, the precise mechanism by which MCNS causes AKI has not been fully elucidated. Read More

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http://dx.doi.org/10.1159/000507426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204776PMC

Early Renal Involvement in Cats with Natural Feline Morbillivirus Infection.

Animals (Basel) 2020 05 10;10(5). Epub 2020 May 10.

Faculty of Veterinary Medicine, Veterinary University Hospital, University of Teramo, Località Piano d'Accio, 64100 Teramo, Italy.

Feline morbillivirus (FeMV) is a newly discovered paramyxovirus infecting domestic cats and its role in the pathogenesis of feline chronic kidney disease (CKD) has been suggested, however not confirmed. The primary aim of the study was to evaluate the renal damage associated with FeMV infection in cats. In this retrospective study, clinical and clinicopathological data were compared among 14 FeMV naturally infected, 21 CKD and 22 healthy cats. Read More

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http://dx.doi.org/10.3390/ani10050828DOI Listing

Hematological and serum biochemical profile in cattle experimentally infected with foot-and-mouth disease virus.

Vet World 2020 Mar 9;13(3):426-432. Epub 2020 Mar 9.

Indian Council of Agricultural Research-Indian Veterinary Research Institute, Bengaluru, Karnataka, India.

Background And Aim: Foot-and-mouth disease (FMD) is an acute viral infection affecting cloven-hoofed animals causing vesicular erosions in the oral cavity and interdigital space. The present study was undertaken to ascertain the time-dependent changes in clinical, hematological, and biochemical profiles in different breeds of cattle following experimental infection.

Materials And Methods: The animals were inoculated with 1. Read More

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http://dx.doi.org/10.14202/vetworld.2020.426-432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183469PMC

Retrospective Analysis of Mortality Cases in Advanced and Metastatic Solid Tumors With Concurrent Prerenal Azotemia.

In Vivo 2020 May-Jun;34(3):1515-1519

Division of Hemato-Oncology, Department of Internal Medicine, Chang-Gung Memorial Hospital and Chang-Gung University College of Medicine, Taoyuan, Taiwan, R.O.C.

Background/aim: A retrospective study of cases with metastatic or advanced solid tumors complicated with AKI (acute kidney injury) with prerenal azotemia.

Patients And Methods: Criteria included: (1) advanced or metastatic solid tumors that led to mortality; (2) prerenal azotemia identified upon renal function evaluation and (3) BUN to Cr ratio (BCR)≥15. We also compared the outcomes of patients with BCR>20 with those of patients with BCR=15-20. Read More

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http://dx.doi.org/10.21873/invivo.11939DOI Listing
February 2020

Atypical clinical presentation of distal renal tubular acidosis: a case report registered in Amazonas, Brazil.

J Bras Nefrol 2020 Apr 27. Epub 2020 Apr 27.

Universidade Federal do Amazonas, Hospital Universitário Getúlio Vargas, Manaus, AM, Brasil.

We report an unusual case of a 24-year-old girl with a history of recurrent hypokalemic paralysis episodes and skin lesions on the lower limbs and buttocks, both of which had an acute evolution. In subsequent investigations, the patient also had nephrocalcinosis, nephrolithiasis, hyperchloremic metabolic acidosis and persistent alkaline urinary pH. The findings were consistent with distal renal tubular acidosis as the cause of hypokalemic paralysis. Read More

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http://dx.doi.org/10.1590/2175-8239-JBN-2019-0224DOI Listing

Urine kidney safety biomarkers improve understanding of indirect intra-renal injury potential in dogs with a drug-induced prerenal azotemia.

Toxicology 2020 Jun 27;439:152462. Epub 2020 Apr 27.

Safety Assessment and Laboratory Animal Resources, Merck & Co., Inc., West Point, PA, 19486, USA.

Drug-induced kidney injury (DIKI) is a frequent occurrence in nonclinical drug development. It is well established that novel urine kidney safety biomarkers will outperform urea nitrogen (BUN) and serum creatinine (sCr) for monitoring direct drug injury to the kidney across numerous compounds spanning diverse mechanisms and efforts are underway for a formal regulatory clinical qualification. However, it remains unclear how these novel biomarkers will perform under prerenal azotemia when BUN and sCr are elevated but no intra-renal injury is suspected. Read More

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http://dx.doi.org/10.1016/j.tox.2020.152462DOI Listing

Acute kidney injury: A critical care perspective for orthotopic liver transplantation.

Best Pract Res Clin Anaesthesiol 2020 Mar 17;34(1):69-78. Epub 2019 Dec 17.

Division of Gastroenterology (Liver Unit), University of Alberta, Edmonton, Canada; Department of Critical Care Medicine, University of Alberta, Edmonton, Canada. Electronic address:

Acute kidney injury (AKI) is associated with high perioperative mortality in patients undergoing liver transplantation (LT). In the era of Model of End-stage Liver Disease score-based allocation, more patients with impaired renal function are receiving LT. The majority of preoperative AKI is secondary to azotemia, including hepatorenal syndrome - a progressive form of renal impairment unique to liver failure. Read More

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http://dx.doi.org/10.1016/j.bpa.2019.12.002DOI Listing

Clinicopathological characteristics of light chain proximal tubulopathy in Korean patients and the diagnostic usefulness of immunohistochemical staining for immunoglobulin light chain.

BMC Nephrol 2020 Apr 23;21(1):146. Epub 2020 Apr 23.

Department of Pathology, Seoul National University Hospital, Seoul, 03080, Republic of Korea.

Background: Light chain proximal tubulopathy (LCPT) is a rare paraproteinemic renal disease that has been mostly reported in Western patients. LCPT is characterized by the accumulation of immunoglobulin (Ig)-light chain (LC) in the proximal tubule. Immunohistochemical staining for Ig-LC has not been investigated in the context of LCPT. Read More

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http://dx.doi.org/10.1186/s12882-020-01813-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178968PMC

Urine hemojuvelin in cats with naturally occurring kidney disease.

J Vet Intern Med 2020 May 23;34(3):1222-1230. Epub 2020 Apr 23.

Institute of Veterinary Clinical Science, School of Veterinary Medicine, College of Bio-Resources and Agriculture, National Taiwan University, Taipei City, Taiwan.

Background: Soluble-type hemojuvelin in serum and urine has been shown to be a biomarker in humans for chronic kidney disease (CKD) and acute kidney injury (AKI). No similar research has been conducted on cats.

Objective: Urine hemojuvelin (u-hemojuvelin) can be used as a clinical indicator for cats with various renal diseases. Read More

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http://dx.doi.org/10.1111/jvim.15781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255673PMC

Low-dose 17α-ethinyl estradiol (EE) exposure exacerbates lupus renal disease and modulates immune responses to TLR7/9 agonists in genetically autoimmune-prone mice.

Sci Rep 2020 Mar 23;10(1):5210. Epub 2020 Mar 23.

Infectious Disease Research Facility (IDRF), Department of Biomedical Sciences and Pathobiology, VA-MD College of Vet. Medicine, Virginia Tech, Blacksburg, VA, USA.

Estrogens have been shown to regulate the immune system and modulate multiple autoimmune diseases. 17α-ethinyl estradiol (EE), a synthetic analog of 17β-estradiol, is prescribed commonly and found in oral contraceptives and hormone replacement therapies. Surprisingly, few studies have investigated the immunoregulatory effects of exposure to EE, especially in autoimmunity. Read More

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http://dx.doi.org/10.1038/s41598-020-62124-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090002PMC

A Syndrome of Apparent Renal Failure.

Ann Emerg Med 2020 Mar 30. Epub 2020 Mar 30.

Departments of Medicine and Cardiology, Wexham Park Hospital, Frimley Health NHS Foundation Trust, Slough, UK; Department of Cardiology, University of Cyprus Medical School, Nicosia, Cyprus. Electronic address:

Pseudo-azotemia is the syndrome of hypercreatininemia and hyperkaliemia without a change in glomerular filtration rate or structure of the kidney. A 57-year-old vulnerable woman with learning difficulties experienced an intraperitoneal bladder rupture in the absence of a pelvic fracture after a fall. It is suspected that the blunt force compression of a distended bladder situated above the bony protection of the pelvis resulted in delayed intraperitoneal bladder rupture. Read More

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http://dx.doi.org/10.1016/j.annemergmed.2020.02.018DOI Listing

Relationship between the values of blood parameters and physical status in Korean native calves with diarrhea.

J Vet Sci 2020 Mar;21(2):e17

Laboratory of Large Animal Medicine, College of Veterinary Medicine & Institute of Veterinary Science, Kangwon National University, Chuncheon 24341, Korea.

Dehydration, electrolyte disturbance, and acid-base imbalance are the most significant consequences of diarrhea in calves. We aimed to determine blood gas, hematological, electrolyte, and biochemical values and investigate the relationship between the physical status and blood parameters in Korean native calves (KNCs) with diarrhea. One hundred eighty KNCs with diarrhea (age < 75 days) were investigated. Read More

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http://dx.doi.org/10.4142/jvs.2020.21.e17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113571PMC

AMYLOIDOSIS IN CARACALS ().

J Zoo Wildl Med 2020 Mar;51(1):202-209

Center for Zoo and Wild Animal Health, Copenhagen Zoo, Roskildevej 38, 2000 Frederiksberg, Denmark.

Nine cases of amyloidosis in caracals () from three different institutions in Europe were reviewed and evaluated histopathologically. The six males and three females died between 2008 and 2018 at an age of 6 yr ± 2.5 mo (median ± interquartile range). Read More

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http://dx.doi.org/10.1638/2019-0005DOI Listing

[The results of treatment of newborns with postrenal anuria due to upper urinary tract obstruction, caused by fungal bezoar].

Urologiia 2020 Mar(1):81-85

Rostov Regional Pediatric Hospital, Rostov-on-Don, Russia.

Aim: To evaluate the results of different methods of urine derivation in patients with postrenal anuria due to upper urinary tract (UUT) obstruction, caused by fungal bezoar.

Materials And Methods: The results of treatment of postrenal anuria in 8 patients without congenital obstructive anomalies of UUT in 5 clinics from 2004 to 2018 were analyzed. All patients from the birth received continuously two or more antibiotics for diseases not related to kidneys and the urinary tract. Read More

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Compliance With Biochemical Objectives in Patients on Renal Replacement Therapy Before Kidney Transplantation in Mexico.

Transplant Proc 2020 May 11;52(4):1090-1093. Epub 2020 Mar 11.

Medical Research Unit in Nephrological Diseases, Specialty Hospital, 21st Century National Medical Center, Mexican Social Security Institute, Mexico City, Mexico.

Objectives: The biochemical conditions in which patients arrive before renal transplantation (RT) are rarely evaluated; examples of them are found in the Dialysis Outcomes and Practice Patterns Study (DOPPS). The objective of our study was to ascertain the fulfillment of biochemical goals for patients on renal replacement therapy before RT.

Material And Methods: Observational, retrospective study of patients who were on a RT protocol between 2012 and 2017 in 2 RT centers in Mexico. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.01.050DOI Listing

Let Them Eat Healthy: Can Emerging Potassium Binders Help Overcome Dietary Potassium Restrictions in Chronic Kidney Disease?

J Ren Nutr 2020 Mar 5. Epub 2020 Mar 5.

Division of Nephrology, Hypertension and Kidney Transplantation, University of California, Irvine, School of Medicine, Irvine, California.

Potassium-rich foods might provide many health benefits even to people who have declining renal function. The barrier to obtaining these health benefits has long been the concern over hyperkalemia. There are new and novel treatment options available which may enable patients with chronic kidney disease to obtain the health benefits of eating a diet that contains foods such as fruits and vegetables which are high in potassium while reducing the risk of hyperkalemia. Read More

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http://dx.doi.org/10.1053/j.jrn.2020.01.022DOI Listing
March 2020
2.548 Impact Factor

Successful medical management of perinephric abscess and urosepsis following urethral obstruction in a cat.

J Vet Emerg Crit Care (San Antonio) 2020 May 24;30(3):318-324. Epub 2020 Feb 24.

Allegheny Veterinary Emergency Trauma & Specialty, Monroeville, PA.

Objective: To describe the clinical presentation and medical management of a cat with perinephric abscessation and urosepsis following urethral obstruction and catheterization.

Case Summary: A 2-year-old intact male domestic shorthaired cat presented to an emergency and referral center for lethargy, vomiting, and hematuria. Severe azotemia and hyperkalemia were observed on a serum biochemistry panel. Read More

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http://dx.doi.org/10.1111/vec.12946DOI Listing

IL-6-mediated hepatocyte production is the primary source of plasma and urine neutrophil gelatinase-associated lipocalin during acute kidney injury.

Kidney Int 2020 May 28;97(5):966-979. Epub 2019 Nov 28.

Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, Colorado, USA; Renal Section, Rocky Mountain Regional VA Medical Center, Aurora, Colorado, USA. Electronic address:

Neutrophil gelatinase associated lipocalin (NGAL, Lcn2) is the most widely studied biomarker of acute kidney injury (AKI). Previous studies have demonstrated that NGAL is produced by the kidney and released into the urine and plasma. Consequently, NGAL is currently considered a tubule specific injury marker of AKI. Read More

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http://dx.doi.org/10.1016/j.kint.2019.11.013DOI Listing

Systemic lime sulfur toxicosis secondary to dermal exposure in two cats.

J Vet Emerg Crit Care (San Antonio) 2020 May 19;30(3):302-307. Epub 2020 Feb 19.

ASPCA Animal Poison Control Center, Urbana, IL.

Objective: To describe a case series of systemic lime sulfur toxicosis secondary to topical administration in 2 cats.

Case Summary: Two cats from the same household that were being previously treated for Microsporum canis were presented following topical administration of an incorrectly diluted lime sulfur dip. A 30% solution was used rather than the recommended 3% solution, resulting in a 10-fold concentration overdose. Read More

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http://dx.doi.org/10.1111/vec.12935DOI Listing

The Sick Adult Horse: Renal Clinical Pathologic Testing and Urinalysis.

Vet Clin North Am Equine Pract 2020 Apr 6;36(1):121-134. Epub 2020 Feb 6.

Department of Large Animal Clinical Sciences, Veterinary Medical Center, College of Veterinary Medicine, Michigan State University, Room D-202, 736 Wilson Road, East Lansing, MI 48824, USA.

Clinicopathologic evaluation of renal function and renal disease in sick adult horses remains grounded in detection of azotemia, assessment of serum and urine electrolyte concentrations, and evaluation of urinalysis findings, including specific gravity, reagent strip analysis, and sediment examination. Because increases in serum or plasma urea nitrogen and creatinine concentrations are insensitive indicators of a decreased glomerular filtration rate, there is considerable interest in identifying novel biomarkers of renal function or injury in blood and urine, with serum symmetric dimethylarginine concentration being the most recent addition to the commercial market. Read More

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http://dx.doi.org/10.1016/j.cveq.2019.12.003DOI Listing

The impact of acute kidney injury by serum creatinine or urine output criteria on major adverse kidney events in cardiac surgery patients.

J Thorac Cardiovasc Surg 2020 Jan 9. Epub 2020 Jan 9.

Department of Critical Care Medicine, The Center for Critical Care Nephrology, University of Pittsburgh, Pittsburgh, Pa. Electronic address:

Objectives: Oliguria after cardiac surgery remains of uncertain clinical significance. Therefore, we investigated the relationship of acute kidney injury severity across urine output and creatinine domains with the risk for major adverse kidney events at 180 days. We aimed to determine the impact of acute kidney injury after cardiac surgery. Read More

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http://dx.doi.org/10.1016/j.jtcvs.2019.11.137DOI Listing
January 2020

Immune response to influenza vaccination in ESRD patients undergoing hemodialysis vs. hemodiafiltration.

PLoS One 2020 3;15(2):e0227719. Epub 2020 Feb 3.

Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Background: On-line hemodiafiltration (HDF) clears more azotemic toxins compared to high-flux hemodialysis (HD). The response to vaccination is impaired in dialysis patients. We wished to determine whether the immune responses to influenza vaccine in dialysis patients treated by HDF were stronger than those treated by HD. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0227719PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996846PMC
April 2020
3.234 Impact Factor

Utility of commercially available reagent test strips for estimation of blood urea nitrogen concentration and detection of azotemia in pet rabbits () and ferrets ().

J Am Vet Med Assoc 2020 Feb;256(4):449-454

Objective: To evaluate the utility of commercially available reagent test strips for estimation of BUN concentration and detection of azotemia in pet rabbits () and ferrets ().

Sample: 65 blood samples from 53 rabbits and 71 blood samples from 50 ferrets of various health statuses.

Procedures: BUN concentrations were measured with a clinical laboratory biochemical analyzer and estimated with a reagent test strip. Read More

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http://dx.doi.org/10.2460/javma.256.4.449DOI Listing
February 2020

Acute kidney injury due to Leptospira interrogans in 4 foals and use of renal replacement therapy with intermittent hemodiafiltration in 1 foal.

J Vet Intern Med 2020 Mar 30;34(2):1007-1012. Epub 2020 Jan 30.

Swiss Institute of Equine Medicine, University of Bern, and Agroscope, Bern, Switzerland.

Four 2-month-old foals were presented to an equine hospital with acute kidney injury caused by Leptospira interrogans infection. Clinical signs were nonspecific and included lethargy, fever, and unwillingness to nurse. The most important hematologic and clinicopathologic findings were azotemia, anemia, thrombocytopenia, hyponatremia, and hypochloremia. Read More

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http://dx.doi.org/10.1111/jvim.15713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096627PMC
March 2020
1.879 Impact Factor

Postmortem urinary tract changes in cats with urethral obstruction.

J Vet Emerg Crit Care (San Antonio) 2020 Mar 27;30(2):187-193. Epub 2020 Jan 27.

University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA.

Objective: To report the gross and histopathological postmortem findings of the urinary tract and compare them to clinical severity of disease in cats with urethral obstruction (UO).

Design: Retrospective, observational, descriptive study.

Setting: University teaching hospital. Read More

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http://dx.doi.org/10.1111/vec.12924DOI Listing

Acute Kidney Injury and Electrolyte Abnormalities After Chimeric Antigen Receptor T-Cell (CAR-T) Therapy for Diffuse Large B-Cell Lymphoma.

Am J Kidney Dis 2020 Jan 20. Epub 2020 Jan 20.

Renal Division, Department of Internal Medicine, Massachusetts General Hospital, Boston, MA. Electronic address:

Rationale & Objective: Cytokine release syndrome is a well-known complication of chimeric antigen receptor T-cell (CAR-T) therapy and can lead to multiorgan dysfunction. However, the nephrotoxicity of CAR-T therapy is unknown. We aimed to characterize the occurrence, cause, and outcomes of acute kidney injury (AKI), along with the occurrence of electrolyte abnormalities, among adults with diffuse large B-cell lymphoma receiving CAR-T therapy. Read More

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http://dx.doi.org/10.1053/j.ajkd.2019.10.011DOI Listing
January 2020

Evaluation of serum symmetric dimethylarginine as a biomarker of kidney disease in canine leishmaniosis due to Leishmania infantum.

Vet Parasitol 2020 Jan 18;277:109015. Epub 2019 Dec 18.

Companion Animal Clinic, School of Veterinary Medicine, Aristotle University of Thessaloniki (CAC-AUTh), 11 Stavrou Voutyra Str., 54627, Thessaloniki, Greece. Electronic address:

Canine leishmaniosis (CanL)-associated chronic kidney disease is a leading cause of morbidity and mortality in Mediterranean countries. Novel renal biomarkers, such as serum symmetric dimethylarginine (sSDMA), may be useful surrogates for the detection of renal functional impairment. The objectives of this study were to investigate sSDMA concentrations in dogs with CanL, with and without azotemia, and to establish any potential association with the prevalence and severity of proteinuria, with the prevalence of decreased urine specific gravity and with the LeishVet clinical stages of CanL. Read More

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http://dx.doi.org/10.1016/j.vetpar.2019.109015DOI Listing
January 2020

Association of abdominal effusion with a single decompressive cystocentesis prior to catheterization in male cats with urethral obstruction.

J Vet Emerg Crit Care (San Antonio) 2020 Jan 16;30(1):11-17. Epub 2019 Dec 16.

Department of Clinical Sciences, The Ohio State University, Columbus, OH.

Objective: To evaluate the occurrence of abdominal effusion and its association with decompressive cystocentesis in male cats with urethral obstruction.

Design: Prospective observational clinical study.

Animals: Forty-five male neutered, client-owned cats with naturally occurring urethral obstruction. Read More

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http://dx.doi.org/10.1111/vec.12914DOI Listing
January 2020

Serum concentration of homocysteine in spontaneous feline chronic kidney disease.

Vet J 2019 Dec 22;254:105358. Epub 2019 Aug 22.

Department of Veterinary Medicine, University of Milan, Via Celoria 10, 20133 Milan, Italy; Veterinary Teaching Hospital, University of Milan, Via dell'Università 6, 26900 Lodi, Italy.

Serum homocysteine (Hcy) increases in people and dogs with chronic kidney disease (CKD). Hyperhomocysteinemia (HHcy) has also been associated with CKD-related hypertension and proteinuria. The aims of this study were to: (1) validate an enzymatic method for quantification of Hcy in feline serum; (2) evaluate whether HHcy was associated with the presence and severity of CKD, proteinuria or hypertension; and (3) determine whether HHcy could predict disease progression. Read More

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http://dx.doi.org/10.1016/j.tvjl.2019.105358DOI Listing
December 2019

Urinary proteome of dogs with kidney injury during babesiosis.

BMC Vet Res 2019 Dec 4;15(1):439. Epub 2019 Dec 4.

Department of Epizootiology and Clinic of Infectious Diseases, University of Life Sciences, Głęboka 30, 20- 612, Lublin, Poland.

Background: Acute kidney injury is the most frequent complication of babesiosis in dogs and may provide a natural model for identifying early and specific markers of kidney injury in this species. There are limited data on urine proteomics in dogs, and none of the effect of babesiosis on the urine proteome. This study aimed to identify urinary proteins of dogs with kidney injury during the natural course of babesiosis caused by Babesia canis, and to compare them with proteins in a control group to reveal any potential biomarkers predicting renal injury before the presence of azotemia. Read More

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http://dx.doi.org/10.1186/s12917-019-2194-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894246PMC
December 2019

Hypercalcemic Crisis in a Patient with Post-Surgical Hypoparathyroidism.

Case Rep Endocrinol 2019 12;2019:3503651. Epub 2019 Nov 12.

Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Calcium alkali syndrome (CAS), a relatively unusual etiology of hypercalcemia, is characterized by a classical triad of hypercalcemia, azotemia, and metabolic alkalosis. This condition has been described in patients who have taken an excess dose of calcium with an alkali or with a volume-depletion status. To diagnose CAS it requires a high index of suspicion and a detailed history of medication/supplement intake specifically for calcium-containing drugs and a history of all possible ingested alkali. Read More

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http://dx.doi.org/10.1155/2019/3503651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874932PMC
November 2019

N-Acetylglucosamine is the most effective glucosamine derivative for the treatment of membranous nephropathy in rats.

Pharmazie 2019 11;74(11):667-670

Nephroprotective drug development for optimizing treatment of chronic kidney disease (CKD) is an important task of pharmaceutical science. Our study evaluated nephroprotective properties of the two glucosamine derivatives N-acetylglucosamine and glucosamine hydrochloride in a 3-week-long parenteral and oral daily administration at doses of 50 mg/kg in rats with doxorubicin nephropathy. Nephroprotective activity (NA) was evaluated by determining the functional state of the kidneys, the level of azotemia and the activity of free-radical processes in the renal tissue. Read More

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http://dx.doi.org/10.1691/ph.2019.9733DOI Listing
November 2019

Chromogranin A pathway: from pathogenic molecule to renal disease.

J Hypertens 2020 Mar;38(3):456-466

Department of Medicine.

Background: Chromogranin A (CHGA) is an index granin protein critical for biogenesis and exocytotic release of catecholamine storage granules. It is elevated in plasma of patients with sympathetic over-activity and kidney dysfunction. Several CHGA polymorphisms are associated with hypertensive kidney disease. Read More

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http://dx.doi.org/10.1097/HJH.0000000000002295DOI Listing

Retrospective evaluation of the clinical course and outcome following grape or raisin ingestion in dogs (2005-2014): 139 cases.

J Vet Emerg Crit Care (San Antonio) 2020 Jan 12;30(1):60-65. Epub 2019 Nov 12.

Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI.

Objective: To describe the prevalence of acute kidney injury (AKI), clinical course, decontamination procedures, and outcome in dogs following grape or raisin ingestion.

Design: Retrospective case series from 2005 to 2014.

Setting: Three university veterinary teaching hospitals. Read More

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http://dx.doi.org/10.1111/vec.12905DOI Listing
January 2020
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Clinical Significance of Urinary Neutrophil Gelatinase-associated Lipocalin Levels in Defining the Various Etiologies of Acute Kidney Injury in Liver Cirrhosis Patients.

Korean J Gastroenterol 2019 Oct;74(4):212-218

Department of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.

Background/aims: A diagnosis of hepatorenal syndrome (HRS) is based on a differential evaluation of acute kidney injury (AKI), which may aggravate the clinical course. This study assessed the clinical significance of the urinary neutrophil gelatinase- associated lipocalin (u-NGAL) levels in a differential diagnosis of AKI in patients with liver cirrhosis (LC).

Methods: Patients with LC who developed AKI were enrolled prospectively. Read More

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http://dx.doi.org/10.4166/kjg.2019.74.4.212DOI Listing
October 2019

Vitamin D Toxicity: A Prospective Study from a Tertiary Care Centre in Kashmir Valley.

Indian J Endocrinol Metab 2019 May-Jun;23(3):363-366

Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Kashmir, Jammu and Kashmir, India.

Background: Vitamin D toxicity (VDT), a "not uncommon" cause of hypercalcemia, can be life-threatening and cause substantial morbidity, if not treated promptly.

Aims: To describe presentation, management, and outcome in 32 patients with VDT diagnosed over 3 years.

Materials And Methods: Patients presenting with VDT at a tertiary care centre in Srinagar Kashmir India were included. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_116_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683682PMC
October 2019
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Mechanisms of kidney dysfunction in the cirrhotic patient: Non-hepatorenal acute-on-chronic kidney damage considerations.

Ann Hepatol 2020 Mar - Apr;19(2):145-152. Epub 2019 Sep 24.

Medica Sur Clinical Foundation, Mexico City, Mexico; The American British Cowdray Medical Center, Mexico City, Mexico; International Renal Research Institute of Vicenza (IRRIV), Vicenza, Italy. Electronic address:

Renal dysfunction is a common finding in cirrhotic patients and has a great physiologic, and therefore, prognostic relevance. The combination of liver disease and renal dysfunction can occur as a result of systemic conditions that affect both the liver and the kidney, although primary disorders of the liver complicated by renal dysfunction are much more common. As most of the renal dysfunction scenarios in cirrhotic patients correspond to either prerenal azotemia or hepatorenal syndrome (HRS), physicians tend to conceive renal dysfunction in cirrhotic patients as mainly HRS. Read More

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http://dx.doi.org/10.1016/j.aohep.2019.06.022DOI Listing
September 2019
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Thrombotic Microangiopathy: An Under-Recognised Cause of Snake-bite-related Acute Kidney Injury.

Indian J Nephrol 2019 Sep-Oct;29(5):324-328

Department of Nephrology, Kasturba Medical College and Hospital, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Introduction: Thrombotic microangiopathy (TMA) as a cause of snake-bite-induced acute kidney injury (AKI) is rarely reported. Very little is known about the clinical course, optimal management, and prognosis of this entity. We describe a series of snake-bite-induced TMA and compare their outcomes with those without TMA. Read More

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http://dx.doi.org/10.4103/ijn.IJN_280_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755934PMC
October 2019
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Fibroblast growth factor 23 and symmetric dimethylarginine concentrations in geriatric cats.

J Vet Intern Med 2019 Nov 30;33(6):2657-2664. Epub 2019 Sep 30.

Department of Comparative Biomedical Science, Royal Veterinary College, University of London, London, United Kingdom.

Background: Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone that is increased in azotemic cats with chronic kidney disease (CKD) and predictive of the onset of azotemia in older cats. The introduction of symmetric dimethylarginine (SDMA) as a biomarker of glomerular filtration rate has led to the identification of cats in which SDMA is increased, but plasma creatinine concentrations remains within reference range. There is currently little understanding of the metabolic changes present in such cats. Read More

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http://dx.doi.org/10.1111/jvim.15590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872607PMC
November 2019
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Abomasal displacement in neonatal dairy calves: Review of recent literature with special emphasis on abomasal torsion.

Vet World 2019 Jul 25;12(7):1121-1125. Epub 2019 Jul 25.

Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan.

Aim: This study aimed to describe the clinicopathological and necropsy findings in neonatal dairy calves affected with right torsion of the abomasum.

Materials And Methods: The history and findings of clinical examination, hematology and serum biochemical analyses and necropsy were described in six neonatal Holstein calves with a confirmed diagnosis of right torsion of the abomasum. Furthermore, a review of the literature was carried out using internet search engines such as PubMed and Google Scholar concerning abomasal displacement in calves. Read More

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http://dx.doi.org/10.14202/vetworld.2019.1121-1125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702550PMC
July 2019
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Concurrent Anti-glomerular Basement Membrane Nephritis and IgA Nephropathy.

J Pathol Transl Med 2019 Nov 16;53(6):399-402. Epub 2019 Sep 16.

Department of Pathology, Chungnam National University School of Medicine, Daejeon, Republic of Korea.

Anti-glomerular basement membrane (GBM) nephritis is characterized by circulating anti-GBM antibodies and crescentic glomerulonephritis (GN) with deposition of IgG along the GBM. In a limited number of cases, glomerular immune complexes have been identified in anti-GBM nephritis. A 38-year-old female presented azotemia, hematuria, and proteinuria without any pulmonary symptoms. Read More

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http://dx.doi.org/10.4132/jptm.2019.08.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877440PMC
November 2019
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Transient Fanconi Syndrome After Treatment with Firocoxib, Cefadroxil, Tramadol, and Famotidine in a Maltese.

J Am Anim Hosp Assoc 2019 Nov/Dec;55(6):323-327. Epub 2019 Sep 16.

From the Department of Veterinary Internal Medicine, College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Gangwon-do, South Korea (J-O.A., J-Y.C.); and the Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Science, College of Veterinary Medicine, Seoul National University, Seoul, South Korea (S-M.K., W-J.S., M-O.R, Q.L., H-Y.Y.).

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http://dx.doi.org/10.5326/JAAHA-MS-6786DOI Listing
September 2019
2 Reads

Pancreatic Langerhans cell histiocytosis in a cat.

J Vet Diagn Invest 2019 Nov 11;31(6):859-863. Epub 2019 Sep 11.

Departments of Pathology and Athens Veterinary Diagnostic Laboratory (Rissi, Brown), Veterinary Biosciences and Diagnostic Imaging (Gendron), and Small Animal Medicine and Surgery (Good, Lane, Schmiedt), College of Veterinary Medicine, University of Georgia, Athens, GA.

In contrast to pulmonary Langerhans cell histiocytosis (LCH), which is a proliferative disorder of Langerhans cells that affects the lungs and other organs of cats, LCH involving a single organ system has not been documented in cats, to our knowledge. Herein we describe a case of pancreatic LCH in a 9-y-old castrated male Domestic Shorthaired cat that was evaluated for possible renal transplantation. The cat was hypoglycemic, hyperinsulinemic, and azotemic. Read More

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http://dx.doi.org/10.1177/1040638719874857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900718PMC
November 2019
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[Can the pre-dialysis period in stage IV chronic kidney disease be prolonged?]

Angiol Sosud Khir 2019 ;25(3):177-181

Samara State Medical University of the RF Ministry of Public Health, Samara, Russia.

Analysed herein are the results of treating a total of 29 patients presenting with stage IV chronic kidney disease (CKD) induced by ischaemic nephropathy. All patients had renal artery stenosis more than 80%, decreased glomerular filtration rate (GFR) below 30 ml/min/1.73m2 and were regarded by the nephrologists as potential candidates for programmed haemodialysis. Read More

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http://dx.doi.org/10.33529/ANGID2019301DOI Listing
November 2019
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Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis.

Cell Metab 2019 10 29;30(4):784-799.e5. Epub 2019 Aug 29.

Renal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA; Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address:

Fibrosis is the final common pathway leading to end-stage renal failure. By analyzing the kidneys of patients and animal models with fibrosis, we observed a significant mitochondrial defect, including the loss of the mitochondrial transcription factor A (TFAM) in kidney tubule cells. Here, we generated mice with tubule-specific deletion of TFAM (Ksp-Cre/Tfam). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15504131193043
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http://dx.doi.org/10.1016/j.cmet.2019.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054893PMC
October 2019
3 Reads

Severe hypernatremia and transient azotemia in a cat following inadvertent intravenous administration of a commercial polyethylene glycol solution.

J Vet Emerg Crit Care (San Antonio) 2019 Nov 31;29(6):690-695. Epub 2019 Aug 31.

Department of Veterinary Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA.

Objective: To describe the clinical signs, clinicopathologic abnormalities, treatment, and outcome after IV administration of polyethylene glycol 3350 (PEG3350) in a cat.

Case Summary: A cat was inadvertently administered 6 g/kg of PEG3350 in electrolyte solution, IV, resulting in severe hypernatremia (203 mmol/L), diffuse encephalopathy, hemolysis, and moderate azotemia. The hemolysis and acute kidney injury observed immediately following PEG3350 administration resolved with supportive care. Read More

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http://dx.doi.org/10.1111/vec.12888DOI Listing
November 2019
1 Read