2,631 results match your criteria Azotemia


[Clinical and microbiological aspects of peritonitis associated with peritoneal dialysis in adult patients with chronic renal failure in the Emergency Department].

Rev Chilena Infectol 2018 ;35(3):225-232

Escuela Superior de Medicina, Instituto Politécnico Nacional, Instituto Mexicano del Seguro Social, México, D.F, México.

Background: Peritonitis is the most important and frequent complication of peritoneal dialysis (PD). Bacterial infections are responsible in most cases, with characteristic symptoms.

Aim: To determine the most frequent pathogens in peritonitis associated with PD in patients with chronic renal failure (CRF). Read More

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January 2018

BK virus nephropathy and multiorgan involvement in a child with heart transplantation
.

Clin Nephrol 2018 Dec 11. Epub 2018 Dec 11.

BK virus is a known cause of renal failure in kidney transplant recipients, but there is little data regarding its effect on native kidneys in heart transplant patients. Here, we describe the case of a child who underwent heart transplantation and was later diagnosed with BK virus with multiorgan involvement. This patient was diagnosed with dilated cardiomyopathy at 4 months of age and underwent heart transplantation at the age of 5 years. Read More

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December 2018

A 52 Years Old Male Presented With Acute Kidney Injury with Hepatitis after Taking Fish Gallbladder.

Authors:
O F Miah F A Dowel

Mymensingh Med J 2018 Oct;27(4):866-868

Dr Mohammad Omar Faruque Miah, Senior Clinical Pathologist, Department of Pathology, Mymensingh Medical College Hospital, Mymensingh, Bangladesh.

A 52 years old male was admitted at National Institute of Kidney Diseases & Urology, Dhaka, Bangladesh on 16th September 2016 with the history of oliguria, nausea, vomiting & swelling of both legs following consumption of rohu fish gall bladder for the permanent remedy of recurrent abdominal discomfort. He was admitted and received antiemetic, proton pump inhibitor. He had azotemia & underwent urgent haemodialysis (HD). Read More

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October 2018

Short- and long-term outcomes after postsurgical acute kidney injury requiring dialysis.

Clin Epidemiol 2018 26;10:1583-1598. Epub 2018 Oct 26.

Division of Nephrology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan,

Objective: Prompt assessment of perioperative complications is critical for the comprehensive care of surgical patients. Acute kidney injury requiring dialysis (AKI-D) is associated with high mortality, yet little is known about how long-term outcomes of patients have evolved. The association of AKI-D with postsurgical outcomes has not been well studied. Read More

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October 2018
4 Reads

A case of entecavir-associated bullous fixed drug eruption and a review of literature.

Turk J Gastroenterol 2018 Nov 19. Epub 2018 Nov 19.

Department of Pathology, Necmettin Erbakan University School of Medicine, Konya, Turkey.

Fixed drug eruption (FDE) is a type of drug reaction characterized by localized erythema, hyperpigmentation, and bullous at the same site(s), generally observed following every intake of a causative drug. Delayed-type cellular hypersensitivity (Type IVC) is considered to play a role in FDE etiology. Several antibiotics, barbiturates, oral contraceptives, nonsteroidal anti-inflammatory drugs, laxative-containing phenolphthalein, metronidazole, and quinine are known to be the primary drugs responsible for FDE. Read More

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November 2018
6 Reads

Myocardial hypertrophy associated with long-term phenylpropanolamine use in a dog.

J Am Vet Med Assoc 2018 Dec;253(11):1452-1459

CASE DESCRIPTION A 9-year-old spayed female Dalmatian was examined because of progressive pelvic limb paraparesis. CLINICAL FINDINGS The dog had a history of chronic urinary incontinence and had been treated with phenylpropanolamine (PPA) for almost 8.5 years. Read More

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December 2018
4 Reads

Non Catether Induced Renal and Inferior Vena Cava Trombosis in a Neonate: A Case Report.

Open Access Maced J Med Sci 2018 Sep 23;6(9):1678-1681. Epub 2018 Aug 23.

Nephrology Department, University Children Hospital, Skopje, Republic of Macedonia.

Background: Neonatal renal vein thrombosis is the most common vascular condition in the newborn kidney, which could lead to serious complication in infants.

Case Report: We report a case of the unilateral renal vein and inferior vena cava thrombosis, presented with gross hematuria and thrombocytopenia in a neonate. The neonate was a macrosomic male born to a mother with hyperglycemia in pregnancy. Read More

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September 2018

A retrospective study of 157 hospitalized cats with pancreatitis in a tertiary care center: Clinical, imaging and laboratory findings, potential prognostic markers and outcome.

J Vet Intern Med 2018 Nov 13;32(6):1874-1885. Epub 2018 Oct 13.

Department of Small Animal Internal Medicine, Koret School of Veterinary Medicine - Veterinary Teaching Hospital and Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel.

Background: Pancreatitis in cats (FP) has been increasingly diagnosed in recent years, but clinical studies of large numbers of affected cats are scarce.

Objectives: To describe a large cohort of cats with FP requiring hospitalization.

Animals: One hundred and fifty-seven client-owned cats. Read More

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November 2018
6 Reads

Subcutaneous ureteral bypass for treatment of bilateral ureteral obstruction in a cat with retroperitoneal paraganglioma.

J Am Vet Med Assoc 2018 Nov;253(9):1169-1176

CASE DESCRIPTION A 7-year-old female domestic shorthair cat was referred for evaluation of azotemia and unilateral hydronephrosis. CLINICAL FINDINGS Abdominal ultrasonography revealed right-sided hydronephrosis and dilation of the proximal aspect of the ureter; the left kidney was small with irregular margins. A highly vascular, irregular retroperitoneal mass, not clearly associated with the ureteral obstruction, was also visualized. Read More

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November 2018
3 Reads

Determination of urea with special emphasis on biosensors: A review.

Biosens Bioelectron 2019 Jan 20;123:36-50. Epub 2018 Sep 20.

Department of Biochemistry, M.D. University, Rohtak 124001, Haryana, India.

Urea is the major end product of nitrogen metabolism in humans, which is eliminated from the body mainly by the kidneys through urine but is also secreted in body fluids such as blood and saliva. Its level in urine ranges from 7 to 20 mg/dL, which drastically rises under patho-physiological conditions thus providing key information of renal function and diagnosis of various kidney and liver disorders. Increase in urea levels in blood, also referred to as azotemia or uremia. Read More

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January 2019
2 Reads

Tear glucose, creatinine, and urea nitrogen concentrations in cats with normal or increased plasma concentrations.

Vet Ophthalmol 2018 Oct 5. Epub 2018 Oct 5.

Small Animal Clinic, College of Veterinary Medicine, University of Leipzig, Leipzig, Germany.

Objective: The aim of the study was to determine the lacrimal fluid (LF) contents of glucose, urea nitrogen, and creatinine in cats.

Animal Studied: A total of 96 cats were included in the study.

Procedure: Venous blood and LF samples were collected. Read More

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October 2018
1 Read

Clinical, morphological, and molecular characterization of an undetermined Babesia species in a maned wolf (Chrysocyon brachyurus).

Ticks Tick Borne Dis 2019 Jan 11;10(1):124-126. Epub 2018 Sep 11.

Diagnostic Medicine/Pathobiology, College of Veterinary Medircine, Kansas State University, 1800 Denison Ave., Manhattan, KS 66506, USA. Electronic address:

A possible novel Babesia species infection of a maned wolf (Chrysocyon brachyurus) was first reported in 2012. The current case details a confirmed report of a maned wolf with infection by an undetermined species of Babesia. As the mortality and morbidity of babesiosis is high, this may become a significant concern to captive maned wolves, which are considered a near-threatened species by the World Association of Zoos and Aquariums. Read More

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January 2019
1 Read

Cholesterol Crystal Embolization to the Kidney and to a Duodenal Leiomyoma.

ACG Case Rep J 2018 29;5:e62. Epub 2018 Aug 29.

Division of Gastroenterology Hepatology and Nutrition, NYU-Winthrop Hospital, Mineola, NY.

Cholesterol crystal embolism can be spontaneous or iatrogenic, and it can involve any organ of the gastrointestinal tract, presenting with common gastrointestinal symptoms such as bleeding, perforation, obstruction, and inflammation. It is therefore considered the "great masquerader," requiring a high level of suspicion because the condition is associated with increased morbidity and mortality. We present a 69-year-old man who presented with gastrointestinal bleeding and azotemia. Read More

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August 2018
1 Read

Biological implant-associated granulomatous inflammation resulting in secondary hypercalcemia and azotemia in a dog.

Clin Case Rep 2018 Sep 25;6(9):1801-1806. Epub 2018 Jul 25.

University of Pennsylvania Philadelphia PA USA.

Implant associated granulomatous inflammation causing hypercalcemia can occur following use of commercial xenogeneic pericardial tissue patches in dogs. Removal of the implant can result in resolution of the hypercalcemia, suggesting a causal relationship between the tissue reaction to a xenogeneic implant and development of hypercalcemia. Read More

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September 2018
1 Read

COMPARISON OF PROPOFOL CONSTANT RATE INFUSION AND ISOFLURANE FOR MAINTENANCE OF ANESTHESIA IN SPEKE'S GAZELLE, GAZELLA SPEKEI.

J Zoo Wildl Med 2018 Sep;49(3):722-731

The aims of this study were to determine if a propofol constant rate infusion (CRI) in Speke's gazelle, Gazella spekei, would serve as an effective alternative maintenance anesthetic, result in shorter recovery times, and improve anesthetic recovery quality when compared with isoflurane. Eight adult gazelle were enrolled in this complete crossover study with a minimum 3-wk washout period. All gazelle were induced with 10 mg/kg intravenous propofol and maintained with either propofol CRI (0. Read More

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September 2018
7 Reads

Retrospective analysis of incidence, clinical features, potential risk factors, and prognostic indicators for aspiration pneumonia in three brachycephalic dog breeds.

J Am Vet Med Assoc 2018 Oct;253(7):869-876

OBJECTIVE To investigate incidence, clinical features, potential risk factors, and prognostic indicators for aspiration pneumonia in Pugs, French Bulldogs, and Bulldogs. DESIGN Retrospective, observational study. ANIMALS 41 brachycephalic dogs with aspiration pneumonia. Read More

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October 2018
1 Read

Renal azotemia and associated clinical and laboratory findings in dogs with Babesia rossi infection.

Vet Parasitol 2018 Aug 29;260:22-29. Epub 2018 Jul 29.

Department of Companion Animal Clinical Studies, Faculty of Veterinary Science, University of Pretoria, Pretoria, Onderstepoort 0110, South Africa.

The occurrence of acute kidney injury in canine babesiosis is not well documented. Furthermore, interpretation of urine specific gravity (USG) to assess renal concentrating ability is hampered by the frequent presence of hemoglobinuria in this disease. This cross-sectional study aimed to test the hypothesis that renal azotemia (RA) is underdiagnosed according to current canine babesiosis literature by determining its occurrence at presentation, using urine osmolality instead of USG to measure urinary concentration. Read More

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August 2018
13 Reads

Limitations of Fractional Excretion of Urea in Clinical Practice.

Hepatology 2018 Sep 4. Epub 2018 Sep 4.

Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

We read an article written by Patidar et al. (1) with interest. The authors performed analysis in patients with cirrhosis who were taking diuretics and diagnosed with acute kidney injury (AKI). Read More

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September 2018
1 Read

Variable saline resuscitation in a murine model of combined traumatic brain injury and haemorrhage.

Brain Inj 2018 Aug 23:1-9. Epub 2018 Aug 23.

a Division of Research, Institute for Military Medicine, Department of Surgery , University of Cincinnati , Cincinnati , OH , USA.

Background: Resuscitation strategies for combined traumatic brain injury (TBI) with haemorrhage in austere environments are not fully established. Our aim was to establish the effects of various saline concentrations in a murine model of combined TBI and haemorrhage, and identify an effective resuscitative strategy for the far-forward environment.

Methods: Male C57BL/6 mice underwent closed head injury and subjected to controlled haemorrhage to a systolic blood pressure of 25 mmHg via femoral artery cannulation for 60 min. Read More

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August 2018
3 Reads

Exceptional mucocutaneous manifestations with amyloid nephropathy: a case report.

J Med Case Rep 2018 Aug 21;12(1):241. Epub 2018 Aug 21.

Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea.

Background: Amyloidosis is a very rare disease that is difficult to diagnose because of the unspecific early clinical manifestations of the disease. Accurate and early diagnosis is extremely important because the effect of treatment is dependent on the extent of disease progression. Sicca syndrome and nail dystrophy are very rare symptoms of amyloidosis. Read More

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August 2018
10 Reads

Assessment and prediction of acute kidney injury in patients with decompensated cirrhosis with serum cystatin C and urine N-acetyl-β-D-glucosaminidase.

J Gastroenterol Hepatol 2018 Jul 30. Epub 2018 Jul 30.

Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.

Background And Aim: For appropriate management of acute kidney injury (AKI) in cirrhotic patients, accurate differentiation of the types of AKI, prerenal azotemia (PRA), hepatorenal syndrome (HRS), and acute tubular necrosis (ATN) is very important. Urine N-acetyl-β-D-glucosaminidase (NAG) has been proposed as a good tubular injury marker in many studies, but its efficacy in cirrhosis is unclear. This study was performed to evaluate the usefulness of urine NAG in patients with decompensated cirrhosis. Read More

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July 2018
6 Reads

Effect of Combined Peritoneal Dialysis and Hemodialysis on Health-Related Quality of Life.

Contrib Nephrol 2018 24;196:135-140. Epub 2018 Jul 24.

Background: In Japan, combined peritoneal dialysis (PD) and hemodialysis (HD) therapy is performed widely as an established modality of renal replacement therapy. This combination therapy is indicated for patients who cannot maintain adequate solute clearance using a standard PD prescription, or those who have uremic symptoms or a state of persistent fluid overload. A common treatment schedule for combined PD + HD therapy consists of 5 days of PD and one HD session per week. Read More

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July 2018
7 Reads

Acute kidney injury in patients with cirrhosis of liver: Clinical profile and predictors of outcome.

Indian J Gastroenterol 2018 05 17;37(3):248-254. Epub 2018 Jul 17.

Department of Nephrology, Madras Medical Mission, 4A, Dr J J Nagar, Mogappair, Chennai, 600 037, India.

Background: Acute kidney injury (AKI) is a common complication of liver cirrhosis and is associated with poor survival. We studied the clinical profile and predictors of in-hospital mortality in patients with cirrhosis of the liver with AKI.

Methods: This retrospective cohort study examined patients at a tertiary care hospital. Read More

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May 2018
6 Reads

The Relation between Pregnancy-Associated Plasma Protein A and Obstructive Sleep Apnea Syndrome.

Can Respir J 2018 3;2018:3297810. Epub 2018 Jun 3.

Pulmonology Department, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey.

Aim: We aimed to investigate the relationship between serum pregnancy-associated plasma protein A (PAPP-A) levels and obstructive sleep apnea syndrome (OSAS).

Materials And Method: 44 patients with OSAS and 44 healthy adults were included in this study. The participants having rheumatic or systemic inflammatory disease, advanced liver or kidney failure, diabetes, heart failure, hypertension, pregnancy, prerenal azotemia, known history of coronary artery disease, any pulmonary disease, rhinitis, or atopy, history of major trauma or surgery within the last six 6 months, and inhaled nasal or systemic corticosteroid use or other anti-inflammatory medications and those with <18 years of age were excluded. Read More

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June 2018
3 Reads

[Canine hypoadrenocorticism - an update on pathogenesis, diagnosis and treatment].

Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Jun 13;46(3):163-175. Epub 2018 Jun 13.

Canine hypoadrenocorticism (HoAC) results from a loss of functional adrenal cortex, the most common etiology of which is an immune-mediated destruction leading to an inadequate production of glucocorticoids and mineralocorticoids. The term "atypical" HoAC is used for a subgroup of dogs with either an isolated glucocorticoid deficiency or a combined glucocorticoid and mineralocorticoid deficiency but normal electrolytes. Dogs with HoAC can present with a large variety of clinical signs, ranging from shaking, weakness, and mild gastrointestinal signs to seizures, hypovolemic shock, and collapse. Read More

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June 2018
5 Reads

Treatment of acute kidney injury secondary to oak intoxication with hemodialysis in a miniature zebu.

J Vet Emerg Crit Care (San Antonio) 2018 Jul 13;28(4):361-365. Epub 2018 Jun 13.

Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, 32608.

Objective: To describe the successful management of acute kidney injury (AKI) secondary to oak intoxication using hemodialysis in a miniature zebu.

Case Summary: A 1-year-old male intact miniature zebu was presented for evaluation of a 2-day history of lethargy, anorexia, decreased urine production, and dry, firm stool. Initial diagnostics revealed severe azotemia and the bull was presumptively diagnosed with AKI secondary to oak intoxication due to free access to oak trees in the pasture. Read More

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July 2018
8 Reads

Treatment of carprofen overdose with therapeutic plasma exchange in a dog.

J Vet Emerg Crit Care (San Antonio) 2018 Jul 13;28(4):356-360. Epub 2018 Jun 13.

Section of Companion Animal Medicine, Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, 70803.

Objective: To report the use of therapeutic plasma exchange (TPE) in a dog with carprofen toxicosis.

Summary: A 6-year-old female neutered Bichon Frise weighing 6.9 kg was examined after it had ingested 72 mg/kg carprofen. Read More

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July 2018
2 Reads

Targeted inhibition of Axl receptor tyrosine kinase ameliorates anti-GBM-induced lupus-like nephritis.

J Autoimmun 2018 Sep 9;93:37-44. Epub 2018 Jun 9.

Division of Immunology, Allergy and Rheumatology, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH 45267 USA. Electronic address:

Glomerulonephritis (GN) is a typical lesion in autoantibody and immune complex disorders, including SLE. Because the Gas6/Axl pathway has been implicated in the pathogenesis of many types of GN, targeting this pathway might ameliorate GN. Consequently, we have studied the efficacy and mechanism of R428, a potent selective Axl inhibitor, in the prevention of experimental anti-GBM nephritis. Read More

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September 2018
7 Reads

Cisplatin nephrotoxicity as a model of chronic kidney disease.

Lab Invest 2018 Aug 1;98(8):1105-1121. Epub 2018 Jun 1.

Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Cisplatin (CP)-induced nephrotoxicity is widely accepted as a model for acute kidney injury (AKI). Although cisplatin-induced chronic kidney disease (CKD) in rodent has been reported, the role of phosphate in the cisplatin-induced CKD progression is not described. In this study, we gave a single peritoneal injection of CP followed by high (2%) phosphate diet for 20 weeks. Read More

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August 2018
6 Reads

Trpc6 inactivation confers protection in a model of severe nephrosis in rats.

J Mol Med (Berl) 2018 Jul 22;96(7):631-644. Epub 2018 May 22.

Department of Biology and Biochemistry, University of Houston, Houston, TX, USA.

Mutations in canonical transient receptor potential-6 (TRPC6) channels give rise to rare familial forms of focal and segmental glomerulosclerosis (FSGS). Here we examined a possible role for TRPC6 in the progression of chronic puromycin aminonucleoside (PAN) nephrosis in Sprague-Dawley rats, a classic model of acquired nephrotic syndromes. We used CRISPR/Cas9 technology to delete a 239-bp region within exon 2 of the Trpc6 gene (Trpc6 allele). Read More

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July 2018
5 Reads

Renal cell carcinoma in a cat with polycystic kidney disease undergoing renal transplantation.

JFMS Open Rep 2018 Jan-Jun;4(1):2055116918766152. Epub 2018 May 4.

Section of Surgery, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Case Summary: A 10-year-old spayed female American Shorthair cat underwent renal transplantation due to worsening chronic kidney disease secondary to polycystic kidney disease. During transplantation, the right kidney grossly appeared to be more diseased than the left and was firmly adhered to the surrounding tissues. An intraoperative fine-needle aspirate of the right native kidney revealed inflammatory cells but no evidence of neoplasia. Read More

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May 2018
2 Reads

Pharmacokinetic and pharmacodynamic properties of orally administered torsemide in healthy horses.

J Vet Intern Med 2018 Jul 17;32(4):1428-1435. Epub 2018 May 17.

Department of Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio.

Background: Diuretic treatment is the mainstay for management of congestive heart failure in horses, and its use has been restricted to injectable medications because no currently data supports the use of PO administered loop diuretics.

Objectives: To determine the pharmacokinetic and pharmacodynamic properties of PO administered torsemide and, determine if PO administered torsemide, could be used as an alternative to injectable diuretics in the horse.

Animals: Six healthy adult mares. Read More

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July 2018
2 Reads

Prognostic importance of plasma total magnesium in a cohort of cats with azotemic chronic kidney disease.

J Vet Intern Med 2018 Jul 27;32(4):1359-1371. Epub 2018 Apr 27.

Department of Clinical Science and Services, Royal Veterinary College, University of London, London, United Kingdom.

Background: Hypomagnesemia is associated with increased mortality and renal function decline in humans with chronic kidney disease (CKD). Magnesium is furthermore inversely associated with fibroblast growth factor 23 (FGF23), an important prognostic factor in CKD in cats. However, the prognostic significance of plasma magnesium in cats with CKD is unknown. Read More

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July 2018
2 Reads

Uremic encephalopathy in a rhesus macaque (Macaca mulatta): A case report and a brief review of the veterinary literature.

J Med Primatol 2018 Apr 25. Epub 2018 Apr 25.

Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.

Background: Uremic encephalopathy is uncommon yet is one of the most severe complications of renal failure. We present a case of acute renal failure and associated cerebral and vascular lesions consistent with uremic encephalopathy in a rhesus macaque (Macaca mulatta).

Methods: A 14-year-old, female, specific-pathogen-free rhesus macaque presented in lateral recumbency, obtunded, severely dehydrated, and hypothermic, with severe azotemia, mild hyponatremia, hypokalemia, hypochloremia, increased anion gap, and hypercholesterolemia. Read More

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April 2018
2 Reads

Invasive Group B streptococcus: multiloculated perinephric abscesses treated with percutaneous drainage.

J Community Hosp Intern Med Perspect 2018 17;8(2):76-79. Epub 2018 Apr 17.

Department of Internal Medicine, SSM St. Mary's Hospital - St. Louis, St. Louis, MO, USA.

Group B streptococcus infections (GBSI) are commonly associated with neonates and pregnant women, but may also affect nonpregnant adults. Among its spectrum of manifestations, perinephric abscess (PA) is exceedingly rare. Comorbid conditions such as diabetes mellitus (DM) and immunosuppression increase the risk of GBSI. Read More

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April 2018
3 Reads

Vanadate-Induced Renal cAMP and Malondialdehyde Accumulation Suppresses Alpha 1 Sodium Potassium Adenosine Triphosphatase Protein Levels.

Toxicol Res 2018 Apr 15;34(2):143-150. Epub 2018 Apr 15.

Division of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

It has been demonstrated that vanadate causes nephrotoxicity. Vanadate inhibits renal sodium potassium adenosine triphosphatase (Na, K-ATPase) activity and this is more pronounced in injured renal tissues. Cardiac cyclic adenosine monophosphate (cAMP) is enhanced by vanadate, while increased cAMP suppresses Na, K-ATPase action in renal tubular cells. Read More

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April 2018
4 Reads

Clinical findings and diagnostic procedures in 270 small ruminants with obstructive urolithiasis.

J Vet Intern Med 2018 May 16;32(3):1274-1282. Epub 2018 Apr 16.

Clinic for Ruminants, Vetsuisse Faculty, University of Bern, Bremgartenstrasse 109a, Bern 3012, Switzerland.

Background: Details of the clinical signs of obstructive urolithiasis in male small ruminants have not been documented in a large population.

Objective: To describe the clinical presentation and diagnostic procedures in a large group of small ruminants with urolithiasis.

Animals: Two hundred and seventy small ruminants (158 sheep and 112 goats). Read More

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May 2018
3 Reads

JAK1/2 inhibition with baricitinib in the treatment of autoinflammatory interferonopathies.

J Clin Invest 2018 Jul 11;128(7):3041-3052. Epub 2018 Jun 11.

Translational Autoinflammatory Disease Section, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.

Background: Monogenic IFN-mediated autoinflammatory diseases present in infancy with systemic inflammation, an IFN response gene signature, inflammatory organ damage, and high mortality. We used the JAK inhibitor baricitinib, with IFN-blocking activity in vitro, to ameliorate disease.

Methods: Between October 2011 and February 2017, 10 patients with CANDLE (chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperatures), 4 patients with SAVI (stimulator of IFN genes-associated [STING-associated] vasculopathy with onset in infancy), and 4 patients with other interferonopathies were enrolled in an expanded access program. Read More

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July 2018
12 Reads

Outcome of elective cholecystectomy for the treatment of gallbladder disease in dogs.

J Am Vet Med Assoc 2018 Apr;252(8):970-975

OBJECTIVE To determine mortality rates for dogs undergoing cholecystectomy and variables associated with failure to survive to hospital discharge. DESIGN Retrospective cohort study. ANIMALS 70 dogs that underwent cholecystectomy for biliary tract disease at a companion animal referral hospital from 2009 through 2015. Read More

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April 2018
3 Reads

Detection and seroprevalence of morbillivirus and other paramyxoviruses in geriatric cats with and without evidence of azotemic chronic kidney disease.

J Vet Intern Med 2018 May 23;32(3):1100-1108. Epub 2018 Mar 23.

Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.

Background: Feline morbillivirus (FeMV) is associated with the presence of tubulo-interstitial nephritis (TIN) in cats, however the seroprevalence of FeMV in the UK and the association between the presence of FeMV and renal azotemia is unknown HYPOTHESIS/OBJECTIVES: To identify whether paramyxoviruses are present in urine samples of geriatric cats and to develop an assay to assess FeMV seroprevalence. To investigate the relationship between both urinary paramyxovirus (including FeMV) excretion and FeMV seroprevalence and azotemic chronic kidney disease (CKD).

Animals: Seventy-nine cats (40 for FeMV detection; 72 for seroprevalence). Read More

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May 2018
5 Reads

Azotemia and Proteinuria in Dogs Infected with Babesia gibsoni.

J Am Anim Hosp Assoc 2018 May/Jun;54(3):156-160. Epub 2018 Mar 20.

T. Ullal's present affiliation is the College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado.

Babesiosis is a hemoprotozoal tick-borne disease that is commonly associated with thrombocytopenia and anemia; however, renal involvement has been documented in dogs. The purpose of this retrospective study was to document azotemia and proteinuria in dogs infected with Babesia sp. and to describe the response to antiprotozoal therapy. Read More

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March 2018
4 Reads

Renal dialysis and long-term treatment of a dog with kidney disease associated with canine leishmaniosis.

Parasit Vectors 2018 03 20;11(1):151. Epub 2018 Mar 20.

Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel.

Background: Renal disease is considered the main cause of natural mortality in dogs with canine leishmaniosis. The pathological mechanisms associated with kidney injury in canine leishmaniosis include immune complex glomerulonephritis, tubulointerstitial nephritis and occasionally renal amyloidosis. Proteinuria is a frequent finding in canine leishmaniosis and its quantification by the urine protein-creatinine ratio (UPC) is an important parameter in the staging of canine lesihmaniosis as presented by the LeishVet group. Read More

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March 2018
7 Reads

Acute glomerulonephritis secondary to .

BMJ Case Rep 2018 Mar 9;2018. Epub 2018 Mar 9.

Hotz Children's Hospital, Jackson Health Sysrem, Miami, Florida, USA.

is a clinically important pathogen that is emerging globally but remains poorly investigated. Here, we report the first case of acute glomerulonephritis resulting from infection with Glomerulonephritis is typically caused by and reports secondary to other strains including and exist. Infection with in this patient was associated with acute nephritis (haematuria, oedema and hypertension), nephrotic syndrome and progressive azotemia. Read More

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March 2018
5 Reads

Central-Variant Posterior Reversible Encephalopathy Syndrome with Albuminocytologic Dissociation.

Case Rep Neurol 2018 Jan-Apr;10(1):29-33. Epub 2018 Feb 2.

Department of Neurology, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea.

Posterior reversible encephalopathy syndrome (PRES) is a disorder of reversible vasogenic brain edema which mainly involves the parieto-occipital lobes in various clinical settings. The main mechanism is known to be cerebral autoregulation failure and endothelial dysfunction leading to the disruption of the blood-brain barrier. We report the case of a 47-year-old woman with PRES which involved the brain stem and thalami, sparing the cerebral hemispheres. Read More

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February 2018
1 Read

Surgical and endoscopic treatment of bladder exstrophy-epispadias complex in a female dog.

J Am Vet Med Assoc 2018 Mar;252(6):732-743

CASE DESCRIPTION A 14-week-old 7.7-kg (16.9-lb) sexually intact female Golden Retriever was evaluated because of urine dripping from the caudoventral aspect of the abdomen. Read More

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March 2018
3 Reads

Treatment of pyonephrosis with a subcutaneous ureteral bypass device in four cats.

J Am Vet Med Assoc 2018 Mar;252(6):744-753

CASE DESCRIPTION 4 cats were examined because of ureteral obstruction. CLINICAL FINDINGS Clinical and clinicopathologic abnormalities were nonspecific and included anorexia, lethargy, weight loss, anemia, leukocytosis, neutrophilia, lymphopenia, and azotemia. A diagnosis of pyonephrosis was made in all cats. Read More

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March 2018
3 Reads

Use of a modified Boari flap for the treatment of a proximal ureteral obstruction in a cat.

Vet Surg 2018 May 5;47(4):578-585. Epub 2018 Mar 5.

Hope Veterinary Specialists, Malvern, Pennsylvania.

Objective: To describe the use and long term outcome of a novel surgical technique developed to treat a proximal ureteral obstruction in a cat.

Study Design: Case report.

Animals: A 3-year-old female spayed Russian blue cat. Read More

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May 2018
18 Reads

Concurrent renal amyloidosis and thymoma resulting in a fatal ventricular thrombus in a dog.

J Vet Intern Med 2018 May 27;32(3):1160-1165. Epub 2018 Feb 27.

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa.

Thymoma-associated nephropathies have been reported in people but not in dogs. In this report, we describe a dog with thymoma and concurrent renal amyloidosis. A 7-year-old castrated male Weimaraner was presented for progressive anorexia, lethargy, and tachypnea. Read More

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May 2018
5 Reads

Calcitonin Response to Naturally Occurring Ionized Hypercalcemia in Cats with Chronic Kidney Disease.

J Vet Intern Med 2018 Mar 22;32(2):727-735. Epub 2018 Feb 22.

Department of Clinical Science and Services, Royal Veterinary College, University of London, London, United Kingdom.

Background: Hypercalcemia is commonly associated with chronic kidney disease (CKD) in cats.

Objectives: To explore the calcitonin response to naturally occurring ionized hypercalcemia in cats with azotemic CKD, and to assess the relationship of plasma calcitonin with ionized calcium, alkaline phosphatase (ALP), and urinary calcium excretion.

Animals: Thirty-three client-owned cats with azotemic CKD and ionized hypercalcemia from first opinion practice. Read More

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March 2018
2 Reads

Uremia: A historical reappraisal of what happened
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Clin Nephrol 2018 May;89(5):305-313

Urea was identified as a urinary salt in 1662 and was the first organic bodily product to be synthesized in vitro in 1828. This heralded the end of an era that defined disease as an imbalance between vital life forces, and catalyzed the merging of organic chemical sciences into clinical medicine. The term urée (urea) was introduced in 1803, its accumulation in blood was dubbed urémie (uremia) in 1847, and the procedure for its removal from urine across semi-permeable membranes designated dialysis in 1861. Read More

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May 2018
8 Reads