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    Vitamin D status and its association with insulin resistance among type 2 diabetics: A case -control study in Ghana.
    PLoS One 2017 19;12(4):e0175388. Epub 2017 Apr 19.
    Nkawie Government Hospital, Kumasi, Ghana.
    Background: Vitamin D plays a major role in physiological processes that modulate mineral metabolism and immune function with probable link to several chronic and infectious conditions. Emerging data suggests a possible influence of vitamin D on glucose homeostasis. This study sought to provide preliminary information on vitamin D status among Ghanaian type 2 diabetics and assessed its association with glucose homeostasis. Read More

    Deficiency of superoxide dismutase promotes cerebral vascular hypertrophy and vascular dysfunction in hyperhomocysteinemia.
    PLoS One 2017 17;12(4):e0175732. Epub 2017 Apr 17.
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America.
    There is an emerging consensus that hyperhomocysteinemia is an independent risk factor for cerebral vascular disease and that homocysteine-lowering therapy protects from ischemic stroke. However, the mechanisms by which hyperhomocysteinemia produces abnormalities of cerebral vascular structure and function remain largely undefined. Our objective in this study was to define the mechanistic role of superoxide in hyperhomocysteinemia-induced cerebral vascular dysfunction and hypertrophy. Read More

    Enhanced offspring predisposition to steatohepatitis with maternal high-fat diet is associated with epigenetic and microbiome alterations.
    PLoS One 2017 17;12(4):e0175675. Epub 2017 Apr 17.
    Arkansas Children's Nutrition Center, Little Rock, Arkansas, United States of America.
    Objective: Non-alcoholic fatty liver disease (NAFLD) is an important co-morbidity associated with obesity and a precursor to steatohepatitis. However, the contributions of gestational and early life influences on development of NAFLD and NASH remain poorly appreciated.

    Methods: Two independent studies were performed to examine whether maternal over-nutrition via exposure to high fat diet (HFD) leads to exacerbated hepatic responses to post-natal HFD and methionine choline deficient (MCD) diets in the offspring. Read More

    Association Between Vitamin D Status and Schizophrenia: A First Psychotic Episode Study.
    J Nerv Ment Dis 2017 May;205(5):409-412
    *Psychiatry Department, Hospital San Rafael, Vall d'Hebron University Hospital, FIDMAG Germanes Hosptalàries Research Foundation, CIBERSAM; and †Rheumatology Department, Hospital San Rafael, Barcelona, Spain.
    Vitamin D deficiency has been linked with schizophrenia. We aimed to determine whether patients with a first episode of psychosis (FEP) had lower vitamin D levels compared with controls considering their final diagnosis. We conducted a cross-sectional study determining 25-hydroxyvitamin D blood levels. Read More

    Plasma metabolomics in adults with cystic fibrosis during a pulmonary exacerbation: A pilot randomized study of high-dose vitamin D3 administration.
    Metabolism 2017 May 11;70:31-41. Epub 2017 Feb 11.
    Division of Endocrinology, Metabolism & Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA; Center for Cystic Fibrosis and Airways Disease Research, Children's Healthcare of Atlanta, Atlanta, GA, USA; Section of Endocrinology, Atlanta Veterans Affairs Medical Center, Atlanta, GA, USA.
    Background: Cystic fibrosis (CF) is a chronic catabolic disease often requiring hospitalization for acute episodes of worsening pulmonary exacerbations. Limited data suggest that vitamin D may have beneficial clinical effects, but the impact of vitamin D on systemic metabolism in this setting is unknown.

    Objective: We used high-resolution metabolomics (HRM) to assess the impact of baseline vitamin D status and high-dose vitamin D3 administration on systemic metabolism in adults with CF with an acute pulmonary exacerbation. Read More

    Association of vitamin D deficiency, season of the year, and latent tuberculosis infection among household contacts.
    PLoS One 2017 12;12(4):e0175400. Epub 2017 Apr 12.
    Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
    Objectives: Vitamin D (VD) enhances the immune response against Mycobacterium tuberculosis in vitro, and VD deficiency has been described in patients with active tuberculosis (TB). However, the role of hypovitaminosis D in the pathogenesis of early TB infection acquisition is unclear. We aimed to evaluate the association of VD deficiency, season of the year, and latent TB infection in household contacts (HHC), given that this is a potentially modifiable condition often related to nutritional deficiencies and lack of sun exposure. Read More

    A rare case of a non-traumatic neck of femur fracture in a 17-year-old boy associated with vitamin D deficiency.
    BMJ Case Rep 2017 Apr 6;2017. Epub 2017 Apr 6.
    Sandwell General Hospital, West Bromwich, Sandwell, UK.
    Hip fractures in the young, healthy population are rare and often the result of high-energy trauma. A previously healthy 17-year-old patient presented to our institution with a 5-week history of left hip and knee pain in the absence of any trauma. Pelvic radiograph revealed a subacute left femoral neck fracture. Read More

    Effects of Vitamin B6 Deficiency on the Composition and Functional Potential of T Cell Populations.
    J Immunol Res 2017 6;2017:2197975. Epub 2017 Mar 6.
    Research Center for Food Safety and Nutrition, Key Lab of Urban Agriculture (South), Bor S. Luh Food Safety Research Center, School of Agriculture & Biology, Shanghai Jiao Tong University, Shanghai 200240, China.
    The immune system is critical in preventing infection and cancer, and malnutrition can weaken different aspects of the immune system to undermine immunity. Previous studies suggested that vitamin B6 deficiency could decrease serum antibody production with concomitant increase in IL4 expression. However, evidence on whether vitamin B6 deficiency would impair immune cell differentiation, cytokines secretion, and signal molecule expression involved in JAK/STAT signaling pathway to regulate immune response remains largely unknown. Read More

    Adult-onset hypophosphatemic osteomalacia associated with Sjogren syndrome: Clinical case report.
    Medicine (Baltimore) 2017 Mar;96(13):e6493
    aDepartment of Nuclear Medicine, West China Hospital of Sichuan University bDepartment of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
    Rationale: Hypophosphatemic osteomalacia (HO) is a metabolic bone disease, exhibiting different etiologies such as genetic mutation, tumor induction, dysimmunity, or renal disease. Sjogren's syndrome (SS) is a connective tissue disorder commonly involving exocrine glands; however kidney involvement is also encountered, leading to abnormal phosphorus metabolism, even HO.

    Patient Concerns: A 47-year-old female patient presented progressively worsening pain in the chest wall, back and bilateral lower extremities as well as muscle weakness was referred to our department. Read More

    Association between serum 25-hydroxyvitamin D and carotid atherosclerotic plaque in Chinese type 2 diabetic patients.
    Medicine (Baltimore) 2017 Mar;96(13):e6445
    aDepartment of Cardiology, Zhejiang Provincial People's Hospital bDepartment of Cardiology, Lishui Central Hospital, Lishui, Zhejiang Province cDepartment of Geriatrics dDepartment of Orthopedics, Zhejiang Provincial People's Hospital, Hangzhou, China.
    In this study, we investigated the distribution of vitamin D and its association with carotid atherosclerotic plaque (CP) in Chinese type 2 diabetic (T2D) patients. We performed a cross-sectional study in 210 T2D and 94 age- and gender-matched nondiabetic patients during winter months, by determining serum 25-hydroxyvitamin D (25(OH)D) levels in both diabetic and nondiabetic controls. We carried out measurements of B-mode ultrasonography of carotid arteries in each T2D patient. Read More

    Genetic risk scores, sex and dietary factors interact to alter serum uric acid trajectory among African-American urban adults.
    Br J Nutr 2017 Mar 27;117(5):686-697. Epub 2017 Mar 27.
    1Laboratory of Epidemiology and Population Sciences,National Institute on Aging (NIA),National Institutes of Health, Intramural Research Program (NIH/IRP),Baltimore,MD 21224,USA.
    Serum uric acid (SUA), a causative agent for gout among others, is affected by both genetic and dietary factors, perhaps differentially by sex. We evaluated cross-sectional (SUAbase) and longitudinal (SUArate) associations of SUA with a genetic risk score (GRS), diet and sex. We then tested the interactive effect of GRS, diet and sex on SUA. Read More

    Vitamin D deficiency and diabetes.
    Biochem J 2017 Mar 24;474(8):1321-1332. Epub 2017 Mar 24.
    The Babraham Institute, Babraham, Cambridge CB22 3AT, U.K.
    Vitamin D deficiency has been linked to the onset of diabetes. This review summarizes the role of Vitamin D in maintaining the normal release of insulin by the pancreatic beta cells (β-cells). Diabetes is initiated by the onset of insulin resistance. Read More

    Physical Activity, Vitamin D, and Incident Atherosclerotic Cardiovascular Disease in Whites and Blacks: The ARIC Study.
    J Clin Endocrinol Metab 2017 Apr;102(4):1227-1236
    Ciccarone Center for the Prevention of Heart Disease, Division of Cardiology, Johns Hopkins University School of Medicine, and.
    Context: Physical activity (PA) is associated with 25-hydroxyvitamin D [25(OH)D] levels. Both are associated with atherosclerotic cardiovascular disease (ASCVD), but their joint association with ASCVD risk is unknown.

    Objective: To examine the relationship between PA and 25(OH)D, and assess effect modification of 25(OH)D and PA with ASCVD. Read More

    Association of Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorders with Mean Platelet Volume and Vitamin D.
    Med Sci Monit 2017 Mar 20;23:1378-1384. Epub 2017 Mar 20.
    Department of Pediatrics, Medical School, Yüzüncü Yil University, Van, Turkey.
    BACKGROUND The purpose of this study was to assess the values of the mean platelet volume (MPV) in children with attention deficit hyperactivity disorder (ADHD) and with autism spectrum disorders (ASDs) to determine the risk of cardiovascular disease in these 2 disorder groups. MATERIAL AND METHODS The study included a total of 79 patients with ADHD or ASDs and controls in the Van region of Turkey. The control group included subjects of matching age and sex with no ADHD, ASDs, or chronic disease and taking no vitamins. Read More

    Stability of β-carotene during baking of orange-fleshed sweet potato-wheat composite bread and estimated contribution to vitamin A requirements.
    Food Chem 2017 Aug 30;228:85-90. Epub 2017 Jan 30.
    Department of Food Science, Institute for Food, Nutrition and Well-being, University of Pretoria, Private Bag X20, Hatfield, Pretoria 0028, South Africa.
    Orange-fleshed sweet potato (OFSP) is known to be a rich source of β-carotene, a precursor of vitamin A and a potential tool for fighting vitamin A deficiency (VAD) in developing countries. OFSP flour was incorporated into wheat flour at 10, 20 and 30% (w/w) substitution levels. The stability of β-carotene during baking and the contribution of OFSP-wheat composite breads to vitamin A requirements were evaluated. Read More

    Clinical Epidemiology of Mineral Bone Disorder Markers in Prevalent Hemodialysis Patients in the Xinjiang Uyghur Autonomous Region in China.
    Biomed Res Int 2017 19;2017:2516934. Epub 2017 Feb 19.
    Department of Nephrology, The First Affiliated Hospital of Xinjiang Medical University, Xinjiang, China.
    We investigated the clinical epidemiology of mineral bone disorder markers in prevalent hemodialysis (HD) patients in Xinjiang, the largest province in China. Data were obtained from 59 hospitals. A total of 3725 patients tracked from January 1 to December 31, 2014, were enrolled. Read More

    Vitamin D, bones and muscle: myth versus reality.
    Australas J Ageing 2017 Mar;36 Suppl 1:8-13
    Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts, USA.
    Objectives: Evidence regarding the efficacy and dosing of vitamin D on fall and fracture prevention, with or without calcium, is characterised by uncertainty.

    Methods: A panel of experts was organised at the First Australasian Conference on Sarcopenia and Frailty in Melbourne, Australia, in November 2016 to provide an interpretation of the current evidence and to give their opinions regarding the supplementation of vitamin D in three hypothetical cases.

    Results And Conclusion: The authors conclude that (i) target serum 25(OH)D concentration should be 50 to 60 nmol/L year round, with a conservative upper limit <100 nmol/L; (ii) change in serum concentrations at any given dose is highly variable among individuals; (iii) dosing interval may need to be <2 months to have a continuous benefit; (iv) a loading dose can raise levels to target quickly, but there is no evidence yet that this has any positive effect on falls or fracture outcomes; and (v) a maintenance dose of 1000 IU/day, or given as an equivalent dose weekly or monthly, is sufficient for most individuals. Read More

    Severe hypophosphataemia after intravenous iron administration.
    BMJ Case Rep 2017 Mar 13;2017. Epub 2017 Mar 13.
    Division of Endocrinology, University Hospital Zürich, Zürich, Switzerland.
    Iron deficiency is common and can be effectively treated with parenteral iron infusion. We report a case of an iron-deficient and vitamin D-deficient woman who developed severe symptomatic hypophosphataemia following intravenous ferric carboxymaltose administration. We stress the need of increased awareness of this potential complication among physicians. Read More

    The Strategy to Prevent and Regress the Vascular Calcification in Dialysis Patients.
    Biomed Res Int 2017 14;2017:9035193. Epub 2017 Feb 14.
    Division of Nephrology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; Department of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan.
    The high prevalence of arterial calcification in end-stage renal disease (ESRD) is far beyond the explanation by common cardiovascular risk factors such as aging, diabetes, hypertension, and dyslipidemia. The finding relies on the fact that vascular and valvular calcifications are predictors of cardiovascular diseases and mortality in persons with chronic renal failure. In addition to traditional cardiovascular risk factors such as diabetes mellitus and blood pressure control, other ESRD-related risks such as phosphate retention, excess calcium, and prolonged dialysis time also contribute to the development of vascular calcification. Read More

    Reversal of isolated 20q deletion with vitamin B12 replacement in a patient with pernicious anaemia.
    BMJ Case Rep 2017 Mar 8;2017. Epub 2017 Mar 8.
    Department of Internal Medicine, Louisiana State University Health Sciences Center- Shreveport, LA, USA.
    Severe vitamin B12 deficiency is well known to cause morphological alterations in bone marrow. In rare instances, these myelodysplastic and megaloblastic changes can coexist with cytogenetic abnormalities. Here, we report a case of a 38-year-old African-American woman with pernicious anaemia, who was found to have an isolated 20q deletion and which resolved after vitamin B12 replacement. Read More

    Vitamin D Deficiency in Europeans Today and in Viking Settlers of Greenland.
    Biochemistry (Mosc) 2016 Dec;81(12):1492-1497
    Göring Consulting, Berlin, 12555, Germany.
    The vast majority of the Earth's population lives between the 20th and 40th parallel north and south. It seems that right here humans have found the best living conditions relating not only to temperature and food recourses, but also to UV radiation necessary for the production of vitamin D by human skin. An exception to this general rule is Europe. Read More

    Linking vitamin D status, executive functioning and self-perceived mental health in adolescents through multivariate analysis: A randomized double-blind placebo control trial.
    Scand J Psychol 2017 Apr;58(2):123-130
    Department of Clinical Psychology, University of Bergen, Christiesgt. 12, 5015, Bergen, Norway.
    The aim of the present randomized double-blind placebo control trial was to investigate if vitamin D supplementation had an effect on vitamin D status, executive functioning and self-perceived mental health in a group of Norwegian adolescents during winter time. Fifty adolescents were randomly assigned into an intervention group (vitamin D pearls) or a control group (placebo pearls). Before (pre-test in December/January) and after (post-test in April/May) the intervention period the participants were exposed to a test procedure, consisting of blood draw, completion of cognitive tests (Tower of Hanoi and Tower of London), and the Youth Self-report version of the Child Behavior Checklist. Read More

    Vitamin D deficiency and sufficiency among Canadian children residing at high latitude following the revision of the RDA of vitamin D intake in 2010.
    Br J Nutr 2017 Feb 1;117(3):457-465. Epub 2017 Mar 1.
    1School of Public Health,University of Alberta,Alberta,Canada.
    Recently, countries at high latitudes have updated their vitamin D recommendations to ensure adequate intake for the musculoskeletal health of their respective populations. In 2010, the dietary guidelines for vitamin D for Canadians and Americans aged 1-70 years increased from 5 μg/d to 15 μg/d, whereas in 2016 for citizens of the UK aged ≥4 years 10 μg/d is recommended. The vitamin D status of Canadian children following the revised dietary guidelines is unknown. Read More

    Hypovitaminosis A in extensively grazed beef cattle.
    Aust Vet J 2017 Mar;95(3):80-84
    College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Queensland, Australia.
    Case Report: Vitamin A deficiency was diagnosed in a herd of 97 19-month-old Braford heifers in the Mitchell Grass Downs (Astrebla spp.) bioregion of Hughenden in north-western Queensland during November 2015. Two heifers died after a 48-h history of sternal recumbency and of the 19 that had neurological signs, 7 were blind. Read More

    Lamivudine, Entecavir, or Tenofovir Treatment of Hepatitis B Infection: Effects on Calcium, Phosphate, FGF23 and Indicators of Bone Metabolism.
    Ann Hepatol 2017 March-April;16(2):207-214
    Department of Medicine, Division of Gastroenterology, University of British Columbia, Vancouver, BC, Canada.
    Background: Patients with chronic hepatitis B virus (HBV) are often treated with nucleoside/nucleotide antiviral agents and metabolic bone toxicity is a possible concern.

    Objective: To determine the relationships between fibroblast growth factor 23 (FGF23), a phosphaturic hormone, bone mineral density (BMD), and bone biochemical abnormalities in these patients.

    Material And Methods: This is a cross-sectional observational study comparing HBV-infected subjects treated for at least one year with tenofovir (TDF), lamuvidine (LVD), entacavir (ETV), or not treated (CON). Read More

    The Dramatic Recovery of a Patient with Biguanide-associated Severe Lactic Acidosis Following Thiamine Supplementation.
    Intern Med 2017 15;56(4):455-459. Epub 2017 Feb 15.
    Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Japan.
    Biguanides are a drug of choice for the treatment of type 2 diabetes mellitus. Although they can cause lactic acidosis in susceptible patients with predisposing risk factors, the incidence of lactic acidosis is reported to be very low when they are used properly. We herein present a case of biguanide-associated severe lactic acidosis complicated with thiamine deficiency that was provoked without predisposing factors for thiamine deficiency. Read More

    Megaloblastic Anemias: Nutritional and Other Causes.
    Med Clin North Am 2017 Mar 14;101(2):297-317. Epub 2016 Dec 14.
    Department of Pathology and Laboratory Medicine, UC Davis Medical Center, University of California Davis Health System, 4400 V. Street, Sacramento, CA 95817, USA.
    Vitamin B12 and folate deficiencies are major causes of megaloblastic anemia. Causes of B12 deficiency include pernicious anemia, gastric surgery, intestinal disorders, dietary deficiency, and inherited disorders of B12 transport or absorption. The prevalence of folate deficiency has decreased because of folate fortification, but deficiency still occurs from malabsorption and increased demand. Read More

    Involvement of histone methylation in macrophage apoptosis and unstable plaque formation in methionine-induced hyperhomocysteinemic ApoE(-/-) mice.
    Life Sci 2017 Mar 7;173:135-144. Epub 2017 Feb 7.
    Institute of Cardiovascular Diseases, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, PR China; Heart Centre, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, PR China. Electronic address:
    Aims: Hyperhomocysteinemia (Hhcy) is an independent risk factor of atherosclerosis and promotes unstable plaque formation. Epigenetic mechanisms play an important role in the pathogenesis of atherosclerosis induced by Hhcy. However, the exact mechanism is still undefined. Read More

    Effects of Cholecalciferol vs Calcifediol on Total and Free 25-Hydroxyvitamin D and Parathyroid Hormone.
    J Clin Endocrinol Metab 2017 Apr;102(4):1133-1140
    Department of Orthopaedic Surgery, and.
    Context: Vitamin D deficiency disproportionately affects nonwhite individuals. Controversy persists over how to best restore low 25D levels, and how to best define vitamin D status [total (protein bound plus free) vs free 25D].

    Objective: To assess the effects of vitamin D3 (cholecalciferol, or D3) vs 25-hydroxyvitamin D3 (calcifediol, or 25D3) on total and free 25D in a multiethnic cohort of adults, and whether change in parathyroid hormone (PTH) is more strongly associated with total vs free 25D. Read More

    Modulatory role of Co-enzyme Q10 on methionine and choline deficient diet-induced non-alcoholic steatohepatitis (NASH) in albino rats.
    Appl Physiol Nutr Metab 2017 Mar 9;42(3):243-249. Epub 2016 Nov 9.
    Department of Pharmacology, Medical Division, National Research Centre, 33 EL Bohouth St., Dokki, Giza 12622, Egypt.
    The present study aimed to evaluate the hepato-protective and neuro-protective activity of Co-enzyme Q10 (CoQ10) on non-alcoholic steatohepatitis (NASH) in albino rats induced by methionine and choline-deficient (MCD) diet. Rats were fed an MCD diet for 8 weeks to induce non-alcoholic steatohepatitis. CoQ10 (10 mg/(kg·day)(-1)) was orally administered for 2 consecutive weeks. Read More

    Vitamin D status, hypertension and body mass index in an urban black community in Mangaung, South Africa.
    Afr J Prim Health Care Fam Med 2016 Oct 31;8(1):e1-e5. Epub 2016 Oct 31.
    Department of Nutrition and Dietetics, University of the Free State.
    Background: A strong relationship exists between hypertension and body weight. Research has linked both higher blood pressure and body weight with lower vitamin D status.

    Objective: This study assessed the vitamin D status of a low-income, urban, black community in South Africa, to examine whether serum levels of 25-hydroxy vitamin D [25(OH)D] are associated with hypertension and body mass index (BMI). Read More

    Effects of an L-arginine-based multi ingredient product on endothelial function in subjects with mild to moderate hypertension and hyperhomocysteinemia - a randomized, double-blind, placebo-controlled, cross-over trial.
    BMC Complement Altern Med 2017 Feb 2;17(1):92. Epub 2017 Feb 2.
    Nutritional CRO, BioTeSys GmbH, Schelztorstraße 54-56, 73728, Esslingen, Germany.
    Background: Nutrition plays an important role in prevention and management of cardiovascular diseases (CVD) in early stages. Recent research demonstrated beneficial effects of various nutritional ingredients on vascular health. The aim of the current study was to evaluate the effects of an L-arginine-based multi ingredient product (AbMIP) on vascular function. Read More

    High-dose oral colecalciferol loading in obesity: impact of body mass index and its utility prior to bariatric surgery to treat vitamin D deficiency.
    Clin Obes 2017 Apr 1;7(2):92-97. Epub 2017 Feb 1.
    Department of Endocrinology, St. James' University Hospital, Leeds, UK.
    Obesity is associated with lower vitamin D levels compared with normal weight subjects, and if levels are not replaced prior to bariatric surgery, this can increase fracture risk as bone density typically falls post-operatively. We analysed the effect of body mass index (BMI) on vitamin D levels in response to 300 000 IU of colecalciferol in patients with vitamin D deficiency (<30 nmol L(-1) ). Patients were grouped according to their BMI as normal weight (20-24. Read More

    Association of Serum Vitamin D Levels with Level of Control of Childhood Asthma.
    Indian Pediatr 2017 Jan;54(1):29-32
    Departments of Pediatrics and *Endocrinology, AIIMS, Ansari Nagar, New Delhi, India. Correspondence to: Dr Rakesh Lodha, Professor, Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India.
    Objective: To study the association between serum vitamin D levels and levels of asthma control in children aged 5-15 years.

    Methods: Children with physician-diagnosed asthma who were under follow-up for at least 6 months were enrolled. Participants were categorized into three asthma control groups as per standard guidelines, and their serum 25-hydroxy vitamin D levels and pulmonary function tests were compared. Read More

    Physiological changes and reproductive performance of Sterlet sturgeon Acipenser ruthenus injected with thiamine.
    Anim Reprod Sci 2017 Mar 15;178:23-30. Epub 2017 Jan 15.
    School of Environment and Natural Resources, The Ohio State University, Columbus, OH 43210, USA.
    To evaluate the effects of thiamine on physiological changes and spawning performance of Sterlet sturgeon Acipenser ruthenus, 45 farmed female fish (698.6±8.9g) were randomly distributed in 9 tanks (1000L) and fed a diet with 1g/kg of an anti-thiamine drug. Read More

    X-linked hypophosphatemia and growth.
    Rev Endocr Metab Disord 2017 Mar;18(1):107-115
    Division of Pediatrics, Department of Medicine. Faculty of Medicine, University of Oviedo, Oviedo, Asturias, Spain.
    X-Linked hypophosphatemia (XLH) is the most common form of hereditary rickets caused by loss-of function mutations in the PHEX gene. XLH is characterized by hypophosphatemia secondary to renal phosphate wasting, inappropriately low concentrations of 1,25 dihydroxyvitamin D and high circulating levels of fibroblast growth factor 23 (FGF23). Short stature and rachitic osseous lesions are characteristic phenotypic findings of XLH although the severity of these manifestations is highly variable among patients. Read More

    Vitamin B12 deficiency neuropathy; a rare diagnosis in young adults: a case report.
    BMC Res Notes 2017 Jan 28;10(1):72. Epub 2017 Jan 28.
    Department of Medicine, Faculty of Health Sciences, University of Buea and Global Health Dialogue Foundation, Buea, Cameroon.
    Background: Vitamin B12 deficiency is a metabolic disorder with many causes. It often presents with megaloblastic anaemia and neurological disorders which entail prompt treatment. The diagnosis of Vitamin B12 deficiency is challenging in resource limited-settings due to limited access to diagnostic tools and unfamiliarity with the disease, owing to its rarity especially in young people. Read More

    Investigation of the vitamin D nutritional status in women with gestational diabetes mellitus in Beijing.
    Lipids Health Dis 2017 Jan 28;16(1):22. Epub 2017 Jan 28.
    Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China.
    Background: Vitamin D deficiency is a common issue, which has relation with GDM, during the pregnant period. To study the Vitamin D nutritional status of pregnant women with gestational diabetes mellitus (GDM) in the middle and late pregnancy and analyze the different sources of Vitamin D intake.

    Methods: A total of ninety-eight pregnant women with GDM were enrolled voluntarily in this study. Read More

    Exploring Vitamin B12 Deficiency in Sleeve Gastrectomy from a Histological Study of a Cadaveric Stomach and Ileum.
    J Diet Suppl 2017 Sep 26;14(5):514-520. Epub 2017 Jan 26.
    c Department of Pathology , Ross University School of Medicine , North Brunswick , NJ , USA.
    Introduction: Vitamin B12 deficiency is more commonly found among patients who have undergone Roux-en-Y gastric bypass (RYGB) as compared to those with post-sleeve gastrectomies (SG). The major difference between SG and RYGB is that the latter greatly bypasses the stomach whereas the former simply reduces the gastric volume.

    Purpose: The aim of this article was to study the stomach and the distal ileum histologically in a cadaver with SG to explain the higher rate of incidences of vitamin B12 deficiency seen in patients post-RYGB relative to patients post-SG. Read More

    [Plasma 25-OH Vitamin D Concentrations in Cord Blood after Summer Months, Spain].
    Rev Esp Salud Publica 2017 Jan 25;91. Epub 2017 Jan 25.
    Servicio de Pediatría. Hospital del Mar. Barcelona. España.
    Objective: Plasma vitamin D (25(OH)D) levels in the newborn are dependent on maternal stores. Several studies showing a high prevalence of vitamin D deficiency in pregnant women have been published last years. The aim of the study was to analyze 25(OH)D levels in cord blood after summer month, determine whether there is a relation with different variables. Read More

    Cystatin C is Better than Serum Creatinine for Estimating Glomerular Filtration Rate to Detect Osteopenia in Chronic Kidney Disease Patients.
    Yonsei Med J 2017 Mar;58(2):380-387
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
    Purpose: Recent studies have reported that loss of bone mass is associated with renal function decline and increased fracture risks in chronic kidney disease (CKD) patients. The aim of this study was to investigate the best estimated glomerular filtration rate (eGFR) equation to detect osteopenia in CKD patients.

    Materials And Methods: This was a cross-sectional study, and 780 patients aged 50 years or above were classified into normal bone mass or osteopenia groups according to the -1. Read More

    Vitamin D supplementation for sickle cell disease.
    Cochrane Database Syst Rev 2017 01 20;1:CD010858. Epub 2017 Jan 20.
    Comprehensive Sickle Cell Program, Aflac Cancer and Blood Disorders Service, Emory University School of Medicine, 1405 Clifton Road, NE, Atlanta, Georgia, USA, GA 30322.
    Background: Sickle cell disease is a genetic chronic haemolytic and pro-inflammatory disorder. The clinical manifestations of sickle cell disease result from the presence of mutations on the beta globin genes that generate an abnormal haemoglobin product (called haemoglobin S) within the red blood cell. Sickle cell disease can lead to many complications such as acute chest syndrome, stroke, acute and chronic bone complications (including painful vaso-occlusive crisis, osteomyelitis, osteonecrosis and osteoporosis). Read More

    Vitamin D deficiency and the risk of tuberculosis: a meta-analysis.
    Drug Des Devel Ther 2017 28;11:91-102. Epub 2016 Dec 28.
    Department of Thoracic Surgery, Beijing Chest Hospital, Capital Medical University, Beijing, People's Republic of China.
    Background And Aim: To conduct meta-analyses of all published studies on various aspects of association between vitamin D and tuberculosis (TB).

    Methods: PubMed and Web of Knowledge were searched for all properly controlled studies on vitamin D and TB. Pooled odds ratio, mean difference or standardized mean difference, and its corresponding 95% confidence interval were calculated with the Cochrane Review Manager 5. Read More

    Use of Metformin for Cardiometabolic Risks in Psychiatric Practice: Need-to-Know Safety Issues.
    J Clin Psychiatry 2016 Nov;77(11):e1491-e1494
    Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore, India.
    Metformin, a biguanide drug, is emerging as an important treatment option for the prevention or treatment of weight gain, type 2 diabetes mellitus, and the metabolic syndrome in psychiatric patients, especially those who require or receive antipsychotic drugs. Metformin treatment is commonly associated with gastrointestinal adverse effects; the risk of these is reduced by gradual dose uptitration, administration of the drug with meals, and use of a time-release formulation. Lactic acidosis, a potentially fatal complication of biguanide therapy, is very rare with metformin; the risk can be reduced by avoidance of its prescription in patients with impaired renal function, impaired liver function, cardiac failure, and certain other conditions. Read More

    Serum 25-OH vitamin D levels in systemic sclerosis: analysis of 140 patients and review of the literature.
    Clin Rheumatol 2017 Mar 9;36(3):583-590. Epub 2017 Jan 9.
    Rheumatology Unit, Department of Internal Medicine, University of Modena and Reggio Emilia, Via del Pozzo, 71, 41100, Modena, Italy.
    Hypovitaminosis D is increasingly reported in autoimmune diseases. We investigated the 25-OH-vitamin D (25-OH-vitD) levels in systemic sclerosis (SSc) patients, in correlation with disease's features. We measured the 25-OH-vitD serum levels in 140 consecutive patients (F/M 126/15; mean age 61 ± 15. Read More

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