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Pan Afr Med J 2022 25;41:249. Epub 2022 Mar 25.

Public Health Nutrition Research Consultant, Addis Ababa, Ethiopia.

Introduction: there is a large body of literature that has linked vitamin D status in the population with COVID-19 infection risk and disease severity. However, there is paucity of evidence in African context. Hence, this study aimed to conduct an ecological analysis to explore correlation between population level vitamin D status, COVID-19 infection, and mortality in Africa. Read More

Sci Rep 2022 Jun 21;12(1):10470. Epub 2022 Jun 21.

GReD Institute, Faculté de Médecine, Université Clermont Auvergne-INSERM-CNRS, Clermont-Ferrand, France.

Vitamin D (VD) deficiency reduces the chances of successful fertilization; however, it remains to be validated whether this effect is dependent or not on calcium. To address this question, we generated several situation using a mouse model in which VD content was either increased or decreased in a normo or hypocalcemia context. After the measurement of serum 25-hydroxyvitamin D, calcium and phosphorus levels, an analysis was carried out in terms of oocytes maturation as well as reproductive performance. Read More

Comput Assist Surg (Abingdon) 2022 Dec;27(1):84-90

Department of Orthopedic Surgery, Yokohama City University, Yokohama, Japan.

Planning a three-dimensional (3D) osteotomy using computed tomography (CT) data is useful especially in cases with complex deformities. Furthermore, CT-based navigation system allows the preoperative virtual planning to be replicated in actual surgery. However, one disadvantage when using navigation systems is that when osteotomies are performed on tracker-attached bone, the bone fragments on the side that were cut away cannot be tracked. Read More

Curr Opin Nephrol Hypertens 2022 Jul;31(4):303-305

Division of Nephrology and Hypertension, Department of Medicine and Center for Translational Metabolism and Health, Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Ann Transplant 2022 Jun 21;27:e936009. Epub 2022 Jun 21.

Department of Internal Medicine and Transplant Nephrology, Chair of Pulmonology, Rheumatology and Clinical Immunology, Medical University of Łódź, Łódź, Poland.

BACKGROUND The aim of the study was to assess the relationship between body composition and nutritional status with the level of vitamin D metabolites 25(OH)D and 1,25(OH)₂D in patients in the long term after kidney transplantation (KTx). MATERIAL AND METHODS During 2 routine outpatient visits in summer and winter, the anthropometric and body composition measurements and laboratory data from 105 stable KTx patients were taken and the annual averages were analyzed. RESULTS Data of 64 patients (26 F, 38 M) at mean age 49. Read More

BMJ Case Rep 2022 Jun 20;15(6). Epub 2022 Jun 20.

Paediatric Dentistry, UCL Eastman Dental Institute, London, UK.

Vitamin C deficiency, historically known as scurvy, was associated with sailors in the Victorian times, however, a global review in 2020 suggests it still exists in certain at-risk groups.A case is presented of a young non-verbal child with learning difficulties and on a restricted diet, in which the primary symptom was gingival inflammation. It posed a diagnostic dilemma due to the non-specific symptoms, and a delay in the diagnosis, until vitamin C deficiency was confirmed. Read More

Fertil Steril 2022 Jul;118(1):123-124

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

CMAJ 2022 Jun;194(24):E843

Department of Medicine (Silverstein, Cheung, Lin), University of Toronto; Division of Medical Oncology & Hematology (Cheung, Lin), Sunnybrook Health Sciences Centre; ICES Central (Cheung); Precision Diagnostics and Therapeutics Program (Lin), Sunnybrook Health Sciences Centre; Department of Laboratory Medicine and Pathobiology (Lin), University of Toronto, Toronto, Ont.

S D Med 2022 May;75(5):220-223

Sanford Children's Hospital, Sioux Falls, South Dakota.

We present a case of a 6-week-old infant who presented with seizure-like activity. Workup revealed abnormal coagulation and imaging confirmed intracranial hemorrhage. Parental refusal of vitamin K treatment at birth suggested vitamin K deficiency bleeding (VKDB) in this newborn. Read More

Front Endocrinol (Lausanne) 2022 1;13:863448. Epub 2022 Jun 1.

Spine Disease Research Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Introduction: In postmenopausal women, vitamin D deficiency (as defined by the circulating level of 25(OH)D being below 20 ng/ml (50 nmol/L)) is a regular occurrence. The effect of vitamin D supplementation on the muscle function of postmenopausal women has been controversial. This systematic review and meta-analysis of randomized controlled trials (RCTs) examines and summarizes the effects of vitamin D supplementation on the muscular strength and mobility of postmenopausal women. Read More

Pan Afr Med J 2022 15;41:212. Epub 2022 Mar 15.

Cardiology and Vascular Medicine Department, Faculty of Medicine, Airlangga University, Surabaya, Indonesia.

Introduction: hyperhomocysteinemia (HHcy) may contribute to an increased risk of coronary artery disease (CAD). The underlying mechanisms are not well understood, but other than dietary intake factors, hyperhomocysteinemia may genetically result from a methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism. A cross-sectional study was performed to assess whether this mutation was a potential genetic risk factor for CAD. Read More

Wei Sheng Yan Jiu 2022 May;51(3):381-385

NHC Key Laboratory of Trace Element Nutrition, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China.

Objective: To investigate the vitamin A nutritional status and its related influencing factors of Chinese 18-60 urban adults by analyzing serum retinol level in 2015.

Methods: Serum samples of 42 people, half male and half female, were randomly selected in each point, from the 302 monitoring sites of Chinese adult chronic diseases and nutrition surveillance in 2015. The serum retinol levels were determined by high pressure liquid chromatography(HPLC). Read More

Arthritis Res Ther 2022 Jun 18;24(1):147. Epub 2022 Jun 18.

Department of Public Health and Primary Care, Trinity College Dublin, The University of Dublin, Dublin, Ireland.

Background: The aetiology of ANCA-associated vasculitis (AAV) and triggers of relapse are poorly understood. Vitamin D (vitD) is an important immunomodulator, potentially responsible for the observed latitudinal differences between granulomatous and non-granulomatous AAV phenotypes. A narrow ultraviolet B spectrum induces vitD synthesis (vitD-UVB) via the skin. Read More

Am Fam Physician 2022 Jun;105(6):663-664

Florida State University, Tallahassee, Florida.

PLoS One 2022 16;17(6):e0269394. Epub 2022 Jun 16.

Department of Psychiatry, JSS Medical College & Hospital, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India.

Background: Disorders of mental health are known to affect cognitive functions, hence called as cognitive disorders. Impaired glucose metabolism, insulin resistance, vitamin-D deficiency and oxidative stress are some of the key early events reported to be involved in the pathogenesis of most common cognitive disorders, which include Alzheimer's disease. Type-2 diabetes mellitus (T2DM) is one of the known contributing factors of cognitive impairment and dementia. Read More

Dtsch Arztebl Int 2022 Mar;119(12):216

Am Fam Physician 2022 Jun;105(6):663-664

Florida State University, Tallahassee, FL, USA.

Arch Bronconeumol 2021 Sep 3;57(9):567-568. Epub 2021 Jul 3.

Servicio de Endocrinología y Nutrición, Hospital Universitario Reina Sofía, Murcia, Spain.

Indian Pediatr 2022 Jun;59(6):504

Pediatric Nephrology Division, Puerta del Mar University Hospital, Cádiz, Spain.

Indian Pediatr 2022 Jun;59(6):504

Intensive Care Unit; Hospital Morales Meseguer, Murcia, Spain.

BMC Public Health 2022 Jun 10;22(1):1162. Epub 2022 Jun 10.

Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), No 44, Hojjat-dost Alley, Naderi St, Keshavarz Blvd, Tehran, Iran.

Background: Inadequate health and nutritional literacy is a common problem among adults, associated with poor health outcomes. Therefore, this study aimed to investigate the relationship between health literacy and nutritional literacy to sun exposure behaviour.

Methods: We conducted a cross-sectional study on 261 adults (18-65 years) in Iran. Read More

Nutrients 2022 Jun 6;14(11). Epub 2022 Jun 6.

Department of Public Health, and Department of Anesthesiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310058, China.

We aimed to explore the effect of single nucleotide polymorphism (SNP) in the genes of the vitamin D (VitD) metabolic pathway and its interaction with VitD level during pregnancy on the development of hypertensive disorders of pregnancy (HDP). The study was conducted in the Zhoushan Maternal and Child Health Care Hospital, China, from August 2011 to May 2018. The SNPs in VitD metabolic pathway-related genes were genotyped. Read More

Nutrients 2022 Jun 5;14(11). Epub 2022 Jun 5.

Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Kosciuszki 4, 90-419 Lodz, Poland.

The global prevalence of eye diseases continues to grow, bringing with it a reduction in the activity levels and quality of life of patients, and partial or complete blindness if left untreated. As such, there is considerable interest in identifying more effective therapeutic options and preventive agents. One such agent is vitamin D, known to have a range of anti-cancer, anti-angiogenic, anti-inflammatory and anti-oxidative properties, and whose deficiency is linked to the pathogenesis of a range of cardiovascular, cancer, and inflammatory diseases. Read More

Nutrients 2022 May 31;14(11). Epub 2022 May 31.

Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Science, Norwegian University of Science and Technology, 7491 Trondheim, Norway.

Hypovitaminosis D is prevalent worldwide, and especially in South-Asia. According to the Institute of Medicine (IOM), 25(OH)D levels below 30 nmol/L are defined as vitamin D deficiency (VDD) and levels between 30-50 nmol/L as insufficiency (VDI). Besides its role in calcium homeostasis, it has been postulated that vitamin D is involved in metabolic syndrome. Read More

Nutrients 2022 May 30;14(11). Epub 2022 May 30.

Vascular Medicine Laboratory, Nimes University Hospital, 30900 Nimes, France.

Obesity is associated with vitamin D (VD) deficiency and arterial stiffness. This randomized control trial assessed the effects of VD supplementation during a weight-loss program on carotid intima-media thickness (IMT) and carotid compliance in obese adolescents. Participants were randomly assigned to receive either a 12-week lifestyle program with VD supplementation ( = 13), a lifestyle program without VD supplementation ( = 13) or a control group composed of normal-weight adolescents ( = 18). Read More

Nutrients 2022 May 30;14(11). Epub 2022 May 30.

School of Public Health, Xiamen University, Xiamen 361000, China.

Background: Frailty is associated with adverse health outcomes, and vitamin D (VD) deficiency may be a risk factor. We aimed to identify frailty trajectories and examine the mediating effect of physical activity (PA) on the association between VD deficiency and frailty trajectories.

Methods: We included 2997 participants aged 60 to 85 years from ELSA. Read More

Nutrients 2022 May 29;14(11). Epub 2022 May 29.

Laboratory of Biology and Organisms Physiology, Team of Bioenergetics and Intermediary Metabolism Nutrition and Dietetics in Human Pathologies Post Graduate School, University of Sciences and Technology Houari Boumediene, El Alia, Bab Ezzouar, Algiers 16123, Algeria.

The 25-hydroxyvitamin D (25OHD) deficiency in chronic kidney disease (CKD) is associated with immune system dysfunction (pro-inflammatory cytokines storm) through macrophages renal infiltration, oxidative stress (OxS) damage and athero-thromboembolic risk. Conversely, cholecalciferol supplementation (25OHD-S) prevents kidney fibrosis by inhibition of vascular calcification and nephrotic apoptosis (nephrons reduction). The objective of this study was to investigate the pleiotropic effects of 25OHD-S on immunomodulation, antioxidant status and in protecting against thromboembolic events in deficiency CKD Black and White individuals living in the Southern Sahara (SS). Read More

Nutrients 2022 May 28;14(11). Epub 2022 May 28.

Post Graduate Program in Nutrition, Health Science Center, Federal University of Rio Grande do Norte, Natal 59078-900, Brazil.

Vitamin E deficiency (VED) is associated with clinical repercussions in preterm newborns (PTN), but low levels are also found in full-term newborns (TN). As this inadequacy can compromise neurogenesis in childhood, studies are needed to assess whether there is a difference in vitamin E status among newborns according to gestational age to provide support for neonatal monitoring protocols. This systematic review presents a synthesis of the available information on the vitamin E status among PTN and TN. Read More

Int J Mol Sci 2022 May 29;23(11). Epub 2022 May 29.

Department of Biology and Biotechnology "Charles Darwin", Sapienza University, 00185 Rome, Italy.

The active form of vitamin B6, pyridoxal 5'-phosphate (PLP), is a cofactor for more than 200 enzymes involved in many metabolic pathways. Moreover, PLP has antioxidant properties and quenches the reactive oxygen species (ROS). Accordingly, PLP deficiency causes chromosome aberrations in , yeast, and human cells. Read More

Cells 2022 May 25;11(11). Epub 2022 May 25.

Unité de Biologie Fonctionnelle et Adaptative, Université Paris Cité, CNRS, 75013 Paris, France.

Cystathionine beta synthase (CBS) catalyzes the first step of the transsulfuration pathway from homocysteine to cystathionine, and its deficiency leads to hyperhomocysteinemia (HHcy) in humans and rodents. To date, scarce information is available about the HHcy effect on insulin secretion, and the link between CBS activity and the setting of type 2 diabetes is still unknown. We aimed to decipher the consequences of an inborn defect in CBS on glucose homeostasis in mice. Read More