440 results match your criteria Avicenna journal of phytomedicine[Journal]


Neuroprotective effects of leaf extract in a mice model of cerebral ischemia reperfusion.

Avicenna J Phytomed 2020 Mar-Apr;10(2):202-212

Animal Toxicology and Physiology Specialty Research Unit (ATPSRU), Physiology Division, Department of Zoology, Faculty of Science, Kasetsart University, Bangkok, Thailand.

Objective: The present study investigated possible neuroprotective effects of ethanolic extract of leaf against cerebral ischemic-reperfusion injury in mice.

Materials And Methods: Forty male Institute of Cancer Research (ICR) mice were randomly divided into five groups: (1) Sham + 10% Tween 80, (2) bilateral common carotid artery occlusion (BCCAO) + 10% Tween 80, (3) BCCAO + 300 mg/kg, (4) BCCAO + 600 mg/kg and (5) BCCAO + quercetin 10 mg/kg. Cerebral ischemic-reperfusion (IR) was induced by 30 min of BCCAO followed by 45 min of reperfusion. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103431PMC

Methanol extract and fraction of root tuber modulate liver mitochondrial membrane permeability transition pore opening in rats.

Avicenna J Phytomed 2020 Mar-Apr;10(2):190-201

Laboratories for Biomembrane Research and Biotechnology, Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Nigeria.

Objective: Extracts of (AD) are used in folkloric medicine to treat several diseases and infections. However, their roles in mitochondrial permeability transition pore opening are not known.

Materials And Methods: The viability of mitochondria isolated from Wistar rat liver used in this experiment, was assessed by monitoring their swelling amplitude in the absence of calcium and reversal of calcium-induced pore opening by spermine. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103428PMC

Effect of oil extracts on inflammatory and oxidative stress markers in Behcet's disease: A randomized, double-blind, placebo-controlled clinical trial.

Avicenna J Phytomed 2020 Mar-Apr;10(2):181-189

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.

Objective: Behcet's disease (BD) is a chronic inflammatory disorder characterized by recurrent oral and genital aphthous ulcers, uveitis and skin lesions. Oxidative stress and inflammation have important role in the pathogenesis of BD. The aim of this study was to assess the effect of (NS) oil administration on malondialdehyde (MDA), total anti-oxidant capacity (TAC), tumor necrosis factor-α (TNF-α), IL-10 and high sensitivity C-reactive protein (hs- CRP) levels in patients with BD. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103438PMC

The efficacy of camel milk and Tarangabin (manna of  ( combination therapy on glomerular filtration rate in patients with chronic kidney disease: A randomized controlled trial.

Avicenna J Phytomed 2020 Mar-Apr;10(2):170-180

Department of Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: This study was designed to investigate the effect of camel milk and Tarangabin (manna of ) combination therapy in addition to conventional treatments in patients with chronic kidney disease (CKD).

Materials And Methods: Forty-four patients of 15 to 70 years old, with CKD due to hypertension or diabetes, and estimated glomerular filtration rate (eGFR) of 15-60 ml/min per 1.73 m, were enrolled in this trial. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103430PMC

Silymarin inhibits Toll-like receptor 8 gene expression and apoptosis in Ramos cancer cell line.

Avicenna J Phytomed 2020 Mar-Apr;10(2):161-169

Department of Laboratory Sciences, Borujerd Branch, Islamic Azad University, Borujerd, Iran.

Objective: Silymarin is a herbal extract containing flavonolignans, and it has inhibitory effects against the growth of different cancer cell lines by inducing apoptosis. Toll-like receptors are suggested as a novel and attractive target to treat cancer. The current study aimed at examining the mechanism of silymarin-induced apoptosis in Ramos cells and investigating its effects on expression. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103436PMC

Utilization of a chicken embryo membrane model for evaluation of embryonic vascular toxicity of .

Avicenna J Phytomed 2020 Mar-Apr;10(2):152-160

Executive Secretary of Medical Ethics Committee, Vice-Chancellery of Research and Technology, Shiraz University of Medical Sciences, Shiraz, Iran.

Objective: Extensive research has been done to assess the efficacy of herbs for treating different disorders. () is used in folk medicines for various goals. The application of herbs in medicine is accompanied by harmful effects. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103434PMC

Pomegranate peel extract inhibits internalization and replication of the influenza virus: An study.

Avicenna J Phytomed 2020 Mar-Apr;10(2):143-151

Department of Microbiology, College of Veterinary Medicine, Shahrekord Branch, Islamic Azad University.

Objective: Influenza virus, which is associated with high level of morbidity and mortality, has been recently considered a public health concern; however, the methods of choice to control and treat it are limited. Our previous study showed anti-influenza virus activity of pomegranate peel extract (PPE). In this study, the mechanism through which PPE acts against influenza virus A/Puerto Rico/8/34 (H1N1; PR8) was investigated. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103433PMC

Ethnobotanical knowledge of spp.: The world's largest genus of vascular plants.

Avicenna J Phytomed 2020 Mar-Apr;10(2):128-142

Department of Botany, Research Center for Plant Sciences, Ferdowsi University of Mashhad, Mashhad, Iran.

Objective: L. (Fabaceae) is the largest genus of vascular plants in the world, that comprises an estimated number of 2900 annual and perennial species. The members of this genus have a broad spectrum of usages (e. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103437PMC

Effects of stevia on glycemic and lipid profile of type 2 diabetic patients: A randomized controlled trial.

Avicenna J Phytomed 2020 Mar-Apr;10(2):118-127

Department of Food and Nutrition Policy and Planning Research, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Objective: Stevia () is a natural and healthy alternative sweetener to sugar and artificial sweeteners, which has become important for human diets and food manufactures. In this study, the effects of stevia or sucralose as tea sweeteners on glycemic and lipid profile of type 2 diabetic patients were investigated.

Materials And Methods: A double-blind clinical trial was carried out in 34 type 2 diabetic patients. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103435PMC

Response to Letter to the Editor: "Evaluate the effects of curcumin on the prevention of atrial and ventricular arrhythmias and heart failure in patients with unstable angina".

Avicenna J Phytomed 2020 Mar-Apr;10(2):116-117

Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103429PMC

Letter to the Editor: "Evaluate the effects of curcumin on the prevention of atrial and ventricular arrhythmias and heart failure in patients with unstable angina".

Avicenna J Phytomed 2020 Mar-Apr;10(2):114-115

Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103432PMC

Evaluating bioactive constituents and toxicological effects of aqueous extract of fermented seeds in rats.

Avicenna J Phytomed 2020 Jan-Feb;10(1):101-113

Department of Biochemistry Abia State University, PMB 2000, Uturu, Abia State, Nigeria.

Objective: This study aimed at evaluating the bioactive constituents and the toxicological profile of the aqueous fermented seed extract of .

Materials And Methods: The chemical constituents of fermented were assessed using GC-MS. For acute toxicity study, one-time doses of up to 5000 mg/kg of the extract were orally administered to male and female rats whereas 200, 400 and 800 mg/kg of the extract were orally administered daily for 14 days in sub-acute toxicity investigation. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941688PMC
January 2020

Determining factors for Cannabis use among Moroccans Schizophrenic Patients: A cross sectional study.

Avicenna J Phytomed 2020 Jan-Feb;10(1):89-100

Department of Toxicology, University Hospital Hassan II Fez, BP 1893, road of Sidi Hrazem Fez 30000, Morocco.

Objective: Cannabis use is considered a major clinical problem associated with a poorer outcome in patients with schizophrenia. The objective of the present study was to assess the prevalence of cannabis us among patients with schizophrenia. The assessment consists in comparing some factors related to substance use in a population of schizophrenic patients between cannabis users and non. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941683PMC
January 2020

extract reverses lipopolysaccharide-induced anxiety and depression behaviors in rats.

Avicenna J Phytomed 2020 Jan-Feb;10(1):78-88

Department of Physiology, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran.

Objective: Stressors have an important role in sickness behaviors. We checked the effect of (ZM) extract against lipopolysaccharide (LPS)-induced anxiety and depression behaviors in rats.

Materials And Methods: Rats were distributed in the following groups (n=10): Control, LPS (1 mg/kg), LPS-ZM50, LPS-ZM100 and LPS-ZM200. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941686PMC
January 2020

enhances pentobarbital-induced sleeping behaviors.

Avicenna J Phytomed 2020 Jan-Feb;10(1):70-77

Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: Sleep disorders are among the most common psychiatric and medical conditions. In the present study, the hypnotic effect of was studied in mice

Materials And Methods: The hydro-alcoholic extract (HAE) of and three fractions of it, namely water fraction (WF), ethyl acetate fraction (EAF), and -hexane fraction (NHF), were intraperitoneally (ip) administrated to mice 30 min before injection of sodium pentobarbital (30 mg/kg, ip). Then, 30 min after administration of HAE, motor coordination (rota-rod test) was evaluated. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941693PMC
January 2020

Effect of chamomile on chemotherapy-induced neutropenia in pediatric leukemia patients: A randomized triple-blind placebo-controlled clinical trial.

Avicenna J Phytomed 2020 Jan-Feb;10(1):58-69

Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.

Objective: Chemotherapy-induced neutropenia is one of the main side effects of acute lymphoblastic leukemia (ALL) treatment. In this trial, we evaluated the efficacy of chamomile in management of neutropenia.

Materials And Methods: This randomized triple-blind placebo-controlled clinical trial was carried out in 2-18-year-old children with ALL. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941685PMC
January 2020

Does p-coumaric acid improve cardiac injury following LPS-induced lung inflammation through miRNA-146a activity?

Avicenna J Phytomed 2020 Jan-Feb;10(1):50-57

Cellular and Molecular Research Center, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Objective: In cardiovascular diseases, inflammatory response plays an important role and affects heart function. As a flavonoid compound, p-coumaric acid (pCA), commonly exists in many fruits and vegetables and has a therapeutic effect on inflammatory diseases due to its anti-inflammatory properties. The purpose of the present study was to investigate pCA anti-inflammatory effect and the miRNAs (miRs) signaling pathway involved in cardiac inflammation following lipopolysaccharide-induced acute lung injury (ALI). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941691PMC
January 2020

Carob (Ceratonia siliqua L.) fruit hydro-alcoholic extract alleviates reproductive toxicity of lead in male mice: Evidence on sperm parameters, sex hormones, oxidative stress biomarkers and expression of and .

Avicenna J Phytomed 2020 Jan-Feb;10(1):35-49

Department of Pathobiology, Faculty of Veterinary medicine, Urmia University, Urmia, Iran.

Objective: Carob  is an evergreen tree with fruits that have potent antioxidant activity. The aim of this study was to investigate alleviative effects of carob fruit hydro-alcoholic extract (CFHAE) against reproductive toxicity induced by lead (Pb) in male mice.

Materials And Methods: Forty-two NMRI adult male mice were randomly categorized into 7 groups (N=6). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941692PMC
January 2020

Comparison of Th1/Th2 and Treg/Th17 ratios between wet and dry cupping therapies in Persian medicine.

Avicenna J Phytomed 2020 Jan-Feb;10(1):24-34

Immunology Research Center, School of medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: In Persian medicine (PM), wet-cupping therapy (WCT) is the most utilized approach. WCT is mostly done between the shoulders, which is referred to as "" in the Persian language. CD4+T cells also refer to T helper lymphocytes play a critical role in the immune system. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941689PMC
January 2020

Molecular mechanisms underlying gallic acid effects against cardiovascular diseases: An update review.

Authors:
Ghaidafeh Akbari

Avicenna J Phytomed 2020 Jan-Feb;10(1):11-23

Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.

Objective: The prevalence of cardiovascular diseases (CVDs) is growing. CVDs are the major cause of mortality and have become one of the most important health challenges in developing countries. Gallic acid (GA) is a natural phytochemical which has been widely used against multiple conditions. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941690PMC
January 2020

antibacterial activity of curcumin-meropenem combination against extensively drug-resistant (XDR) bacteria isolated from burn wound infections.

Avicenna J Phytomed 2020 Jan-Feb;10(1):3-10

Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Objective: Burn wound infection is a severe complication of thermal injury. Patients with severe burn injuries need urgent care to diminish complications after severe burns. Wound infections are commonly considered one of the most serious burn complications, particularly those that are caused by extensively drug-resistant (XDR) bacteria with few therapeutic choices. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941687PMC
January 2020

Umbelliprenin, a bioactive constituent from the genus has cytotoxic and apoptotic activity in a dose- and time-dependent manner.

Avicenna J Phytomed 2020 Jan-Feb;10(1):1-2

Cellular and Molecular Research Center, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941684PMC
January 2020

Effects of troxerutin on inflammatory cytokines and BDNF levels in male offspring of high-fat diet fed rats.

Avicenna J Phytomed 2019 Nov-Dec;9(6):597-605

Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Objective: In the present study, we aimed to examine the effect of troxerutin treatment on levels of brain-derived neurotrophic factor (BDNF), and tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), as pro-inflammatory cytokines, in the blood and hippocampus of high-fat diet (HFD) fed dams and their male offspring.

Materials And Methods: Forty virgin female Wistar rats, 3 weeks old, were divided into two groups (n=20/per group) and fed control diet (CD), or HFD for 8 weeks. After mating, pregnant animals were assigned to four subgroups including: control (CD), control+troxerutin (CD+T), high-fat diet (HFD), and HFD+troxerutin (HFD+T) groups. Read More

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http://dx.doi.org/10.22038/AJP.2019.13587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823526PMC
November 2019

Boiss. extract improves spatial memory and learning capacity in scopolamine-induced amnesic rats.

Avicenna J Phytomed 2019 Nov-Dec;9(6):587-596

Herbal and Traditional Research Center, Department of Pharmacognosy, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.

Objective: () has been proposed for memory enhancing in Persian traditional medicine; but to now, no study has been carried out in this field yet. The aim of this research was to study the plant effect on spatial memory in scopolamine-induced amnesia and investigate anticholinesterase effect of .

Material And Methods: Aerial parts of the plant were extracted with methanol and standardized on the basis of rutin content. Read More

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http://dx.doi.org/10.22038/AJP.2019.13540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823527PMC
November 2019

Cytotoxic activity of caffeic acid and gallic acid against MCF-7 human breast cancer cells: An and study.

Avicenna J Phytomed 2019 Nov-Dec;9(6):574-586

Department of Chemistry, School of Sciences, Hakim Sabzevari University, Sabzevar, Iran.

Objective: Phenolic compounds have been considered inhibitors of various cancers.

Material And Methods: In this study, caffeic acid and gallic acid were appraised for their possible effects on apoptotic genes expression in a breast cancer cell line . We also evaluated ligand interaction and ligand binding with estrogen receptor alpha by molecular docking. Read More

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http://dx.doi.org/10.22038/AJP.2019.13475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823530PMC
November 2019

Therapeutic potential of leaf hydroethanolic extract against renal oxidative stress and nephrotoxicity induced by paraquat in rats.

Avicenna J Phytomed 2019 Nov-Dec;9(6):563-573

Clinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Objective: Paraquat is a herbicide with potent toxicity in humans and animals. This study aimed to evaluate the protective effects of () leaf extract on the acute nephrotoxicity and renal oxidative stress caused by paraquat.

Materials And Methods: We randomly assigned forty male rats into five groups (G1-G5). Read More

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http://dx.doi.org/10.22038/AJP.2019.13466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823533PMC
November 2019
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Semen quality, hormone profile and histological changes in male albino rats treated with leaf extract.

Avicenna J Phytomed 2019 Nov-Dec;9(6):551-562

Department of Zoology and Environmental Biology, College of Natural and Applied Sciences, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria.

Objective: In this study, the anti-fertility effect of leaf extract (COLE) was evaluated in adult male rats.

Materials And Methods: Forty rats assigned to 4 groups of 10 rats each, were orally given COLE for 28 days. Group 1 was the control group but groups 2, 3 and 4 were administered with 250, 500 and 1000 mg/kg body weight, respectively and were considered the test groups. Read More

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http://dx.doi.org/10.22038/AJP.2019.13426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823532PMC
November 2019

Thymol has beneficial effects on the experimental model of ulcerative colitis.

Avicenna J Phytomed 2019 Nov-Dec;9(6):538-550

Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.

Objective: Thymol, a natural aromatic monoterpene phenol derived from thymus, possesses anti-inflammatory benefits. Here, we evaluated the potential of thymol therapy in improving an animal model of ulcerative colitis.

Materials And Methods: Luminal instillation of acetic acid was used to induce colitis in male Wistar rats. Read More

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http://dx.doi.org/10.22038/AJP.2019.13383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823534PMC
November 2019

Chemical composition and antibacterial properties of L.

Avicenna J Phytomed 2019 Nov-Dec;9(6):530-537

Medicinal Chemistry Department, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: The present study was conducted to investigate antibacterial properties of fruit and flower of .

Material And Methods: Column chromatography, followed by preparative thin layer chromatography (TLC) was used for final purification. The structure of pure alkaloids was determined using spectroscopic methods (H-NMR, C-NMR, UV and MS). Read More

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http://dx.doi.org/10.22038/AJP.2019.13382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823531PMC
November 2019

Effect of an herbal capsule on chronic constipation among menopausal women: A randomized controlled clinical trial.

Avicenna J Phytomed 2019 Nov-Dec;9(6):517-529

Department of Midwifery, Social Determinants of Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Objective: Chronic constipation is frequently observed in postmenopausal women. An herbal combination including clover plants, Roman anis or Anisone, green anis or fennel, green raisins, Alhagi maurorum, violets, Terminalia chebula, senna and golqand has been introduced in traditional books as an effective laxative. Thus, the present study aimed to assess the effectiveness of the combined herbal capsule on chronic constipation in postmenopausal women. Read More

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http://dx.doi.org/10.22038/AJP.2019.13109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823525PMC
November 2019

Evaluation of the effectiveness of crocin isolated from saffron in treatment of burning mouth syndrome: A randomized controlled trial.

Avicenna J Phytomed 2019 Nov-Dec;9(6):505-516

Oral and Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: Burning mouth syndrome (BMS) is a debilitating disorder with few limited treatment modalities. Because of the proven association between BMS symptoms, and depression and anxiety, treatment modalities that alleviate the two latter etiologic factors can be clinically effective. Thus, owing to the antidepressant and potential analgesic effects of crocin (as an active constituent of saffron), the present study was performed to compare the effect of crocin and citalopram (as control) on BMS symptoms and depression/anxiety in patients with BMS. Read More

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http://dx.doi.org/10.22038/AJP.2019.12764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823529PMC
November 2019

Beneficial effects of pumpkin seed oil as a topical hair growth promoting agent in a mice model.

Avicenna J Phytomed 2019 Nov-Dec;9(6):499-504

Department of Pharmacology and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan university of Medical Sciences, Isfahan, Iran.

Objective: Pumpkin ( L.) seed oil mainly consists of saturated and unsaturated fatty acids. Previously, it was reported that oral administration of pumpkin seed oil (PSO) improved hair growth in male pattern alopecia. Read More

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http://dx.doi.org/10.22038/AJP.2019.13463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823528PMC
November 2019

The mechanism of neuroprotective effect of against serum/glucose deprivation-induced PC12 cell death.

Avicenna J Phytomed 2019 Nov-Dec;9(6):491-498

Department of Traditional Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: Oxidative stress is associated with the pathogenesis of brain ischemia and other neurodegenerative disorders. Previous researches have shown the antioxidant activity of   L. In this project, we studied neuro-protective and reactive oxygen species (ROS) scavenging activities of methanol (MeOH) extract and other fractions isolated from in PC12 cell line in serum/glucose deprivation (SGD) condition. Read More

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http://dx.doi.org/10.22038/AJP.2019.13098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823524PMC
November 2019

Kiwifruit effect on adipose tissue cell size and cholesteryl ester transfer protein gene expression in high-fat diet fed Golden Syrian hamsters.

Avicenna J Phytomed 2019 Sep-Oct;9(5):482-490

Department of Clinical Biochemistry, Hamadan University of Medical Sciences; Hamadan, Iran.

Objective: The effects of kiwifruit on the histology and cell size of adipose tissue in hyperlipidemic models have not yet been reported. Therefore, this study aimed to investigate the effect of kiwifruit on the adipose tissue cell size and activity as well as the gene expression of cholesteryl ester transfer protein (CETP) in high-fat diet (HFD) fed hamsters.

Materials And Methods: Forty-two male Syrian hamsters were divided into six groups. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727434PMC
September 2019

Antimalarial activity of extract and fractions of (Blume) A.DC.

Avicenna J Phytomed 2019 Sep-Oct;9(5):474-481

Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Padjadjaran University, Jatinangor, West Java, Indonesia.

Objective: One of the biggest health problems in the world, which occurs in more than 90 countries, is the spread of malaria. Cep-cepan leaves (), was empirically used as an antimalarial herb in North Sumatra. Since its use has not been scientifically studied, we investigated the antimalarial activity of extract and fractions of against ANKA in a mouse model. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727430PMC
September 2019
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could improve hippocampal tau protein and TNF levels and cognitive behavior defects in a rat model of Alzheimer's disease.

Avicenna J Phytomed 2019 Sep-Oct;9(5):465-473

Pharmacology division of Basic Science Department, School of Vet Med; Shiraz University, Shiraz, Iran.

Objective: (ZM) is a plant with ethnopharmacological value which was recently tested to reduce symptoms of Alzheimer's disease (AD). The aim of the present study was to determine the effect of ZM essential oil on spatial cognitive and noncognitive behavior, as well as hippocampal tau protein and tumor necrosis factor alpha (TNFα) concentrations in rats with AD.

Materials And Methods: Thirty-five adult male Sprague Dawley rats (300±30 g) were randomly divided into 5 groups: control (intact rats); sham (received intracerebroventricular (ICV) microinjection of normal saline); AD control (rats with AD that did not receive any treatment); vehicle control (rats with AD that orally received tween-80, 5% (ZM essential oil vehicle) for 20 days) and experimental (rats with AD that orally received ZM essential oil 100 µl/kg/day for 20 days). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727437PMC
September 2019

The anti-diabetic and antioxidant effects of a combination of , and in diabetic rats.

Avicenna J Phytomed 2019 Sep-Oct;9(5):454-464

Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: Effects of and ethanolic extracts and hydro-ethanolic extract combination were evaluated in streptozotocin (STZ)-induced diabetic rats.

Materials And Methods: Male Wistar rats (n=48) were randomly assigned into: control; diabetic; diabetic+metformin (300 mg/kg); diabetic+dose 1 of herbal combination (438 mg/kg of +214 mg/kg of +857 mg/kg of ); diabetic+dose 2 (642 mg/kg of +214 mg/kg of +642 mg/kg of ); and diabetic+dose 3 (857 mg/kg of +438 mg/kg of +1714 mg/kg t of ). All treatments were given orally by gavage. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727431PMC
September 2019

Gummosin, a sesquiterpene coumarin from is preferentially cytotoxic to human breast and prostate cancer cell lines.

Avicenna J Phytomed 2019 Sep-Oct;9(5):446-453

Department of Pharmacology and Toxicology, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran.

Objective: The present study was conducted to find cytotoxic compounds from oleo-gum-resin of (asafoetida).

Materials And Methods: A dichloromethane extract of asafoetida was subjected to different chromatography analyses (including column chromatography, preparative thin layer chromatography and high performance liquid chromatography) to isolate its bioactive sesquiterpene coumarins. The structures of isolated compounds were elucidated through H-NMR spectra interpretation and comparison with those reported in the literature. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727436PMC
September 2019

Effects of saffron on homocysteine, and antioxidant and inflammatory biomarkers levels in patients with type 2 diabetes mellitus: a randomized double-blind clinical trial.

Avicenna J Phytomed 2019 Sep-Oct;9(5):436-445

Cellular and molecular research center, Department of Immunology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Objective: Type 2 diabetes mellitus (T2DM) is one of the most common health problems worldwide. Studies have shown that saffron and its derivatives may have therapeutic potentials in T2DM through reducing plasma glucose. The present study aimed to evaluate the effects of saffron extract on serum anti-inflammatory and antioxidant variables in T2DM patients. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727435PMC
September 2019
10 Reads

Curcumin effects on myeloperoxidase, interleukin-18 and matrix metalloproteinase-9 inflammatory biomarkers in patients with unstable angina: A randomized clinical trial.

Avicenna J Phytomed 2019 Sep-Oct;9(5):428-435

Department of Internal Medicine, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: Inflammation along with oxidative stress plays an important role in the development, progression, instability and rupture of coronary atherosclerotic plaques. Several studies introduced curcumin (diferuloylmethane) as a wonderful chemical in (turmeric) with appropriate anti-inflammatory and antioxidant effects. The effect of curcumin on inflammatory biomarkers was assessed in several clinical trials. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727433PMC
September 2019
3 Reads

Effects of saffron () on sexual dysfunction among men and women: A systematic review and meta-analysis.

Avicenna J Phytomed 2019 Sep-Oct;9(5):419-427

Department of midwifery, School of nursing and midwifery, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.

Objective: This systematic review and meta-analysis study evaluated the effect of saffron () on sexual dysfunction and its subscales (dimensions) among men and women.

Material And Methods: PubMed/Medline, ScienceDirect, Google Scholar, as well as Scientific Information Database (www.SID. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727438PMC
September 2019

Gastro-protective effect of root hydro-methanolic extract in rats with ethanol-induced peptic ulcer.

Avicenna J Phytomed 2019 Sep-Oct;9(5):410-418

Division of Pharmacology and Toxicology, Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.

Objective: is one of the native plants of Iran and its root is used in folk medicine. This study aimed to evaluate the gastro-protective effect of the hydro-methanolic extract of this plant's roots against ethanol-induced gastric ulcer in rats.

Materials And Methods: The following five groups of seven rats were included in this study: control (C), gastric ulcer (GU), control omeprazole (CO) and two treatment groups (the latter 3 groups were rats with gastric ulcer that orally received omeprazole, 20 mg/kg, or the root extract at 150 and 300 mg/kg (BM 150 and BM 300, respectively) 1 hour before ulcer induction). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727432PMC
September 2019
1 Read

(L.) Schott ethanolic leaf extract and fractions exhibited profound anti-inflammatory activity.

Avicenna J Phytomed 2019 Jul-Aug;9(4):396-409

Department of Pharmaceutical and Medicinal Chemistry Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Nigeria.

Objective: (mas) (L.) Schott, (Dryopteridaceae) is used in traditional medicine, particularly in the Southern parts of Nigeria for the treatment of inflammation, rheumatoid arthritis, wounds and ulcers. In this study, we evaluated the anti-inflammatory activity of its ethanolic leaf extract and fractions. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612247PMC
July 2019
4 Reads

Cytotoxic and anti-proliferative effects of Schrenk extracts on human liver and breast cancer cells.

Avicenna J Phytomed 2019 Jul-Aug;9(4):386-395

Department of Biotechnology, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology Kerman, Iran.

Objective: Schrenk has been consumed in Iranian traditional medicine. In contrary to its close species (e.g. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612246PMC

Administration of troxerutin improves testicular function and structure in type-1 diabetic adult rats by reduction of apoptosis.

Avicenna J Phytomed 2019 Jul-Aug;9(4):374-385

Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Objective: The glucose-reducing effects of troxerutin was previously proven. This study was conducted to evaluate troxerutin effect on testicular structure and spermatozoid parameters in type-1 diabetic adult male rats.

Materials And Methods: Fifty male Wistar rats were randomly classified into 5 groups as follows: control (C), troxerutin (T), diabetic (DM), troxerutin-treated DM (DT) and insulin-treated DM (DI). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612250PMC
July 2019
2 Reads

The effect of hydroalcoholic extract of L. on spatial memory and neuronal density of hippocampal CA1 region in rats with sporadic Alzheimer's disease.

Avicenna J Phytomed 2019 Jul-Aug;9(4):362-373

Department of chemistry, Damghan Branch, Islamic Azad University, Damghan, Iran.

Objective: Alzheimer's disease is a neurodegenerative disorder associated with gradual loss of cognitive and memory abilities. It was shown that the hippocampus is one of the first structures in the brain that is affected by the disease. () is a member of Lamiaceae family and contains various substances. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612251PMC

Effect of crocin on biochemical parameters, oxidative/antioxidative profiles, sperm characteristics and testicular histopathology in streptozotocin-induced diabetic rats.

Avicenna J Phytomed 2019 Jul-Aug;9(4):347-361

Department of Pathobiology, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran.

Objective: Chronic hyperglycemia and overproduction of reactive oxygen species (ROS) are strong predictors of the development of reproductive complications of diabetes. The present study was conducted to determine the effects of crocin on biochemical parameters, oxidative stress, and sperm characteristics as well as testes histopathology in diabetic rats.

Materials And Methods: Twenty-four rats were divided into the four groups as follows: control, untreated diabetic and two crocin (40 and 60 mg/kg/day)-treated diabetic groups. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612253PMC
July 2019
3 Reads

Cytotoxic effects of auraptene against a human malignant glioblastoma cell line.

Avicenna J Phytomed 2019 Jul-Aug;9(4):334-346

Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: Glioblastoma multiforme (GBM) is the deadliest type of primary brain tumors, and the survival of patients is estimated to be only about one year. This study, for the first time, investigated the cytotoxic effects of auraptene on U87 GBM cell line.

Materials And Methods: The cellular toxicity was measured by the MTT assay following 24 and 48-hr treatment with different concentrations of auraptene (0-400μg/ml). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612248PMC
July 2019
2 Reads

The effect of saffron ( L.) supplementation on blood pressure, and renal and liver function in patients with type 2 diabetes mellitus: A double-blinded, randomized clinical trial.

Avicenna J Phytomed 2019 Jul-Aug;9(4):322-333

Department of Endocrinology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Objective: Microalbuminuria and hypertension are the risk factors for diabetic nephropathy, and increased levels of liver enzymes are prevalent among diabetic patients. The aim of this research was to examine the effects of supplementation on nephropathy indices, liver enzymes, and blood pressure in patients with type 2 diabetes (T2D).

Materials And Methods: This placebo-controlled, randomized clinical trial was performed among 80 T2D patients. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612249PMC
July 2019
2 Reads

The effect of a natural vaginal product based on honey on the success of intrauterine insemination (IUI) in infertility treatment.

Avicenna J Phytomed 2019 Jul-Aug;9(4):310-321

Department of pharmaceutical sciences in Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: Due to high prevalence of infertility and increasing tendency towards complementary medicine, this study was conducted to investigate the effect of a vaginal natural product based on honey and 1% extract of on the extent of success of intrauterine insemination (IUI).

Materials And Methods: This non-randomized clinical trial study with a historic control group, was performed on infertile women. In this trial, 159 patients were assigned to the intervention group, and 288 patients were recruited to the control group. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612252PMC
July 2019
2 Reads