380 results match your criteria Avicenna journal of phytomedicine[Journal]


Effects of leaf extract on lipopolysaccharide -induced neuroinflammation in rats: A behavioral and H NMR-based metabolomics study.

Avicenna J Phytomed 2019 Mar-Apr;9(2):164-186

Laboratory of Natural Products, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.

Objective: This research revealed the biochemical outcomes of metabolic dysregulation in serum associated with physiological sickness behavior following lipopolysaccharide (LPS)-induced neuroinflammation in rats, and treatment with (CN). Verification of H NMR analysis of the CN aqueous extract proved the existence of bioactive phytochemical constituents' in extract.

Materials And Methods: Twenty-five rats were subjected to unilateral stereotaxic injection of 10 µL LPS (1 mg/mL), while another ten rats were injected with phosphate-buffered saline (PBS, 10 µL) as control. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448548PMC
April 2019
1 Read

Ethnomedicinal uses of plants for the treatment of nervous disorders at the herbal markets of Bojnord, North Khorasan Province, Iran.

Avicenna J Phytomed 2019 Mar-Apr;9(2):153-163

Department of Biology, Payame Noor University (PNU), Tehran, Iran.

Objective: Since ancient times, plants have been commonly used to cure human ailments by indigenous people throughout the world. Nervous diseases are rising all around the world. This paper provides important ethnobotanical information on plants that are used against neurological disorders and are available in medicinal markets of Bojnord, northeastern Iran. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448544PMC

Phytochemical composition, and cytotoxic, antioxidant, and antibacterial activity of the essential oil and methanol extract of .

Avicenna J Phytomed 2019 Mar-Apr;9(2):143-152

Department of Biology, Faculty of Science, Shahid Bahonar University of Kerman, Kerman, Iran.

Objective: In this study, our aim was to extract, and identify and quantify the chemical composition of essential oils of grown in Kerman, Iran. Moreover, cytotoxic, antioxidant and antimicrobial activity of the essential oil and methanol extract of aerial parts of were reported.

Materials And Methods: GC and GC/MS analysis were used for identifying and quantifying the essential oil components. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448547PMC
April 2019
1 Read

Effect of carvacrol on pulmonary function tests, and total and differential white blood cell counts in healthy volunteers: A randomized clinical trial.

Avicenna J Phytomed 2019 Mar-Apr;9(2):134-142

Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad , Iran.

Objective: This is the first study to evaluate the effect of carvacrol on pulmonary function tests (PFT), and total and differential white blood cell (WBC) counts in healthy volunteers.

Materials And Methods: Thirty healthy volunteers were recruited based on the inclusion and exclusion criteria. The subjects were treated with two doses of carvacrol (1 and 2 mg/kg/day) for 1 month. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448546PMC

Short-course administration of a traditional herbal mixture ameliorates asthma symptoms of the common cold in children.

Avicenna J Phytomed 2019 Mar-Apr;9(2):126-133

Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: Asthma is an increasing chronic respiratory disease affecting over 300 million people worldwide. Several studies have shown that herbal remedies may improve asthma control and reduce asthma symptoms. In this study, the effects of short-course administration of an herbal mixture (ASMATUS) in asthmatic children during viral respiratory tract infection, were evaluated. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448545PMC

Acute and sub-acute oral toxicity of ethanol extract of fruit in male rats.

Avicenna J Phytomed 2019 Mar-Apr;9(2):117-125

Department of PG Studies and Research in Biotechnology and Bioinformatics, Jnanasahyadri, Kuvempu University, Shankaraghatta, Shivamogga, Karnataka, India.

Objective: The plant L. (Caesalpiniaceae) is traditionally used to treat heart diseases, abdominal pain and fever. The present study was aimed to investigate the toxic effects acute and sub-acute administration of ethanol extract of fruit (CFE) in male Wistar rats. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448542PMC
April 2019
1 Read

Treatment of liver and spleen illnesses by herbs: Recommendations of Avicenna's heritage "Canon of Medicine".

Avicenna J Phytomed 2019 Mar-Apr;9(2):101-116

Department of Statistics, Faculty of Basic Sciences, Bu- Ali Sina University, Hamedan, Iran.

Objective: Avicenna (Abu Ali al-Hossein ibn Abdullah ibn Sina) who had a special attention toward diseases treatments, gathered results of ages of herbal medicine experiments on humans and animals in his book "Al-Qānūn fī Ṭibb" or "The Canon of Medicine", which is a reliable book in Iranian traditional medicine. The aim of this research was to build a reliable list of plants effective against liver and spleen diseases, based on Avicenna's book (volume 2).

Materials And Methods: By studying the monographs, introduced agents that have been effective in liver and spleen diseases were identified. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448543PMC
April 2019
1 Read

The neuroprotective effect of BSA-based nanocurcumin against 6-OHDA-induced cell death in SH-SY5Y cells.

Avicenna J Phytomed 2019 Mar-Apr;9(2):92-100

Nanobiology and Nanomedicine Research Centre, Shiraz University of Medical sciences, Shiraz, Iran.

Objective: Parkinson's disease (PD) is regarded as the second most common neurodegenerative disease affecting elderly population. There is a tendency toward finding natural cures to suppress the initiation and progression of this disease. Some epidemiological studies indicated lower incidence of PD in populations that consume curry. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448549PMC

Effect of acupressure on constipation in patients undergoing hemodialysis: A randomized double-blind controlled clinical trial.

Avicenna J Phytomed 2019 Jan-Feb;9(1):84-91

Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: Constipation is one of the most common digestive problems in patients undergoing hemodialysis. It has a negative effect on quality of life in these patients. As routine treatments are not effective in this regard, complementary therapies may help to overcome this condition. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369316PMC
February 2019

The protective effect of Boiss. hydroalcoholic extract on TNF-α production, oxidative stress, and insulin level in streptozotocin-induced diabetic rats.

Avicenna J Phytomed 2019 Jan-Feb;9(1):72-83

Department of Endocrinology, Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Objective: Oxidative stress leads to reactive oxygen species (ROS) overproduction, which causes tissue injury in diabetic patients. The aim of this study was to evaluate the effects of extract on TNF-α, oxidative stress products, and insulin levels as well as lipid profile in diabetic rats.

Materials And Methods: Rats were randomly divided into 6 groups of 10 animals. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369318PMC
February 2019

Antimutagenic, antitumor and estrogen receptor binding activity of the rare plant : An ethnobotanical and chemosystematic approach.

Avicenna J Phytomed 2019 Jan-Feb;9(1):62-71

School of Nursing, Clemson University, Clemson, SC.

Objective: and other members of the Diapensiaceae family have ethnomedicinal history in both Eastern and Western hemispheres. Based on ethnopharmacological and chemosystematic evidence, pharmacological and toxicological bioassays were conducted on the rare plant Oconee Bell, .

Materials And Methods: Extracts were examined in assays for antimutagenicity, antitumor and estrogen receptor (ER)-binding activity. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369323PMC
February 2019

Skin inflammatory reactions to capsaicin in rheumatoid arthritis patients compared to healthy controls.

Avicenna J Phytomed 2019 Jan-Feb;9(1):54-61

Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: Previous studies have examined the role of sensory nerves and neural mediators in symmetrical joint inflammation and autoimmunity in rheumatoid arthritis (RA). In this study, we sought to examine the association between capsaicin skin test and disease activity in RA patients.

Materials And Methods: Eighty RA patients (case group) and 20 healthy volunteers were enrolled in this experiment. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369324PMC
February 2019
1 Read

Effects of standardized hydro-alcoholic extract of leaf on hypertension and biochemical parameters in hypertensive hyperlipidemic type 2 diabetic patients: a randomized, double-blind and placebo-controlled clinical trial.

Avicenna J Phytomed 2019 Jan-Feb;9(1):44-53

Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran.

Objective: To study the blood pressure, lipid and glycemic effects and safety of leaf in the hypertensive hyperlipidemic type 2 diabetic patients.

Materials And Methods: The patients took 350 mg standardized plant leaf hydro-alcoholic extract capsule (n=50) or placebo capsule (n=50) three times daily alongside conventional drugs for 2 months. At the baseline and endpoint, systolic and diastolic blood pressures and blood levels of fasting glucose (FG), 2-hr postprandial glucose (2hPPG), glycosylated hemoglobin (HbA1c), total cholesterol (TC), LDL-C, triglyceride, HDL-C, SGOT, SGPT and creatinine were determined in both groups. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369317PMC
February 2019

Modulation of proliferation and cytokine secretion of human lymphocytes by extracts.

Avicenna J Phytomed 2019 Jan-Feb;9(1):34-43

Autoimmune Diseases Research Center, and Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Objective: L. Hudson has been used in folk medicine for various purposes especially for its anti-inflammatory effects. Lymphocytes play a central role in development of inflammation. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369321PMC
February 2019

Histomorphological effects of the oil extract of seed on benign prostatic hyperplasia induced by exogenous testosterone and estradiol in adult Wistar rats.

Avicenna J Phytomed 2019 Jan-Feb;9(1):21-33

Department of Anatomic and Molecular Pathology, College of Medicine of the University of Lagos, Nigeria.

Objective: (SJ) seed has many health benefits due to its very potent anti-inflammatory and antioxidant properties. Despite its widespread use, it has not been validated for use in the treatment of benign prostatic hyperplasia (BPH). This study was conducted to examine histomorphological effects of SJ seed on BPH that usually causes bladder outlet obstruction. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369320PMC
February 2019

Effects of L-citrulline supplementation on blood pressure: A systematic review and meta-analysis.

Avicenna J Phytomed 2019 Jan-Feb;9(1):10-20

Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.

Objective: We aimed to conduct a systematic review and meta-analysis of clinical trials that examined the effects of L-citrulline supplementation on blood pressure (BP).

Materials And Methods: We searched MEDLINE, SCOPUS, PUBMED and Google scholar databases from inception to November 16, 2017 and 811 papers were identified, of which 8 trials with 10 data sets met the inclusion criteria. Inclusion criteria were: (1) application of randomized clinical trial with either crossover or parallel designs; (2) studies conducted in adults (≥18 y); (3) oral supplementation with L-citrulline compared to control group; (4) expression of sufficient data about systolic and diastolic BP at baseline and at the end of the study in each group. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369322PMC
February 2019

The effects of curcumin on the prevention of atrial and ventricular arrhythmias and heart failure in patients with unstable angina: A randomized clinical trial.

Avicenna J Phytomed 2019 Jan-Feb;9(1):1-9

Department of Internal Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: Inflammation along with oxidative stress has an important role in the pathophysiology of unstable angina which leads to acute myocardial infarction, arrhythmias and eventually heart failure. Curcumin has anti-inflammatory and anti-oxidant effects and thereby, it may reduce cardiovascular complications. This randomized controlled trial aimed to investigate the effects of curcumin on the prevention of atrial and ventricular arrhythmias and heart failure in patients with unstable angina. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369319PMC
February 2019
2 Reads

Topical application of L. fruit gel in management of cutaneous lesions of pemphigus vulgaris: A double-blind, placebo-controlled clinical trial.

Avicenna J Phytomed 2018 Nov-Dec;8(6):543-551

Shiraz Molecular Dermatology Research Center, Department of Dermatology, Shiraz University of Medical Sciences, Shiraz, Iran.

Objective: L. fruit extract has been traditionally used in the treatment of pemphigus vulgaris (PV) lesions in Iran. The aim of this study was to determine the efficacy of fruit gel on healing time of PV lesions in a clinical setting. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235662PMC
November 2018
17 Reads

Arbutin attenuates behavioral impairment and oxidative stress in an animal model of Parkinson's disease.

Avicenna J Phytomed 2018 Nov-Dec;8(6):533-542

Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.

Objective: Arbutin has been shown to have antioxidant and free-radical scavenging properties. The aim of this study was to investigate the effects of arbutin administration on behavioral impairment, and oxidative and nitrosative stress in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced animal model of Parkinson's disease (PD).

Materials And Methods: PD model was developed by 4 intraperitoneal (i. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235658PMC
November 2018
10 Reads

Evaluation of leishmanicidal effect of extract by anti-leishmanial assay using promastigotes of .

Avicenna J Phytomed 2018 Nov-Dec;8(6):524-532

Pharmaceutical Research Centers, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: The extract of different species of has been successfully used as a remedy for treatment of cutaneous leishmaniasis. The aim of this study was to assess the leishmanicidal effect of () extract.

Materials And Methods: Ethanolic percolated and methanolic Soxhlet extract of on promastigotes of at different concentrations of extracts, one positive control group and one negative control group as well as 1 solvent control were prepared and placed in 24-well plates that contained 40,000 parasites/well. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235661PMC
November 2018
1 Read

Saffron () versus duloxetine for treatment of patients with fibromyalgia: A randomized double-blind clinical trial.

Avicenna J Phytomed 2018 Nov-Dec;8(6):513-523

Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Objective: Saffron was found efficient and safe in treatment of neuropsychiatric disorders, in particular depression. We compared the efficacy of saffron with duloxetine in treatment of patients with fibromyalgia.

Materials And Methods: In this double-blind parallel-group clinical trial, outpatients with fibromyalgia were randomized to receive either saffron 15 mg or duloxetine 30 mg starting with 1 capsule per day in the first week followed by 2 capsules per day from week 2 until the end of week 8. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235666PMC
November 2018
30 Reads

methanolic extract triggers apoptosis in HepG2 cells.

Avicenna J Phytomed 2018 Nov-Dec;8(6):504-512

Department of Biochemistry, Biomedical Research Unit and Laboratory Animal Centre (BRULAC), Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.

Objective: The objective of the present study was to evaluate the cytotoxic potentials of in human hepatoma HepG2 cells.

Materials And Methods: HepG2 cells were treated with methanolic extract of at 20, 40 and 80 µg/ml for 24 hr and cytotoxic effect was analyzed by MTT assay. The apoptosis rate was investigated by Hoechst 33342 and annexin V/propidium iodide staining. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235665PMC
November 2018
16 Reads

Efficacy of seeds oil in patients with Behcet's disease: a double-blind randomized controlled trial.

Avicenna J Phytomed 2018 Nov-Dec;8(6):498-503

Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Objective: (NS) is a herbal medicine with anti-inflammatory and anti-oxidant functions. This study was designed to evaluate the effect of oral administration of NS seeds oil on the treatment of Behcet's disease (BD).

Materials And Methods: In this double-blind randomized controlled study, 130 patients with BD were screened and 71 patients with BD were randomly allocated to the treatment (n=37) and control (n=34) groups. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235660PMC
November 2018
1 Read

Protective effect of root against mercuric chloride-induced hepatorenal toxicity in rats.

Avicenna J Phytomed 2018 Nov-Dec;8(6):488-497

Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: The present study was designed to investigate the protective effects of hydroalcoholic extract of against HgCl hepatorenal toxicity in rats.

Materials And Methods: Animals were randomly divided into five groups (n= 6 in each group) and received HgCl and plant's extract, intraperitoneally. Group1 received saline (1 mL/kg/day), group 2 received extract (200 mg/kg/day), group 3 was treated with HgCl (5 mg/kg/day,) and groups 4 and 5 received the extract (100 and 200 mg/kg/day, respectively), 1 hr before HgCl administration. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235663PMC
November 2018
16 Reads

Toxicological profile of the aqueous-fermented extract of in rats.

Avicenna J Phytomed 2018 Nov-Dec;8(6):478-487

Department of Biochemistry Abia State University, PMB 2000, Uturu, Abia State, Nigeria.

Objective: This study was conducted to assess the toxicity profile of the aqueous-fermented extract of in rats.

Materials And Methods: In acute toxicity test, the rats of different groups were orally administered with a single dose of 500, 1000, 2000 and 5000 mg/kg of fermented extract of . The rats were monitored for behavioral changes, toxicity signs and mortality. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235664PMC
November 2018
35 Reads

Smooth muscle relaxant activity of (saffron) and its constituents: possible mechanisms.

Avicenna J Phytomed 2018 Nov-Dec;8(6):475-477

Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235659PMC
November 2018
2 Reads

Enhancing effect of leaves extract on spatial learning, memory and learning flexibility as well as hippocampal choline acetyltransferase activity in mice.

Avicenna J Phytomed 2018 Jul-Aug;8(4):380-388

Department of Zoology, Faculty of Science, Kasetsart University, Bangkok, Thailand.

Objective: The present study investigates the effect of leaf extract on spatial learning, memory, and learning flexibility as well as hippocampal choline acetyltransferase (ChAT) activity in mice.

Materials And Methods: Thirty male ICR mice were randomly divided into three groups including 10% Tween 80, 300 mg/kg and 600 mg/kg. All administrations were done orally for 18 consecutive days. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204150PMC
November 2018
3 Reads

Renoprotective effects of the methanolic extract of against carbon tetrachloride-induced renal injury in rats.

Avicenna J Phytomed 2018 Jul-Aug;8(4):370-379

Department of Health information technology management, School of medicine, Ardabil University of Medical Sciences, Ardabil, Iran.

Objective: Studies have demonstrated that carbon tetrachloride (CCl) increases the generation of reactive oxygen species (ROS) in many tissues including the kidney, heart, lung, brain, and liver. The major aim of the present study was to evaluate the protective activity of extract (TPE) in renal tissues of CCl-intoxicated rats.

Materials And Methods: Animals were divided into seven groups of six rats. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204152PMC
November 2018
15 Reads

Aqueous extract of saffron administration along with amygdala deep brain stimulation promoted alleviation of symptoms in post-traumatic stress disorder (PTSD) in rats.

Avicenna J Phytomed 2018 Jul-Aug;8(4):358-369

Electrophysiology Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.

Objective: Post-traumatic stress disorder (PTSD) as one of the most devastating kinds of anxiety disorders, is the consequence of a traumatic event. L., commonly known as saffron have been traditionally used for treatment of stress and anxiety. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204151PMC
November 2018
2 Reads

Evaluation of hematopoietic stem cell expansion in the presence of garcinol.

Avicenna J Phytomed 2018 Jul-Aug;8(4):350-357

Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

Objective: The application of human cord blood (hCB) is limited to children by using relatively small volume of cord blood that does not contain enough hematopoietic stem cells (HSCs). So, efforts for applying cord blood stem cells in transplantation have led to establishment of some approaches for ex vivo expansion of HSCs such as garcinol.

Materials And Methods: CD133+ HSCs were separated by a magnetic-activated cell sorting (MACS) system. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204147PMC
November 2018
4 Reads

The effect of asafoetida essential oil on myocardial ischemic-reperfusion injury in isolated rat hearts.

Avicenna J Phytomed 2018 Jul-Aug;8(4):338-349

Department of Physiology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Objective: Previous studies reported that asafetida from Linn. species and its essential oil (AEO) have antioxidant effects. In the present study, the effect of AEO was evaluated on ischemic-reperfusion injury in isolated rat hearts. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204149PMC
November 2018
1 Read

The effects of curcumin and a modified curcumin formulation on serum Cholesteryl Ester Transfer Protein concentrations in patients with metabolic syndrome: A randomized, placebo-controlled clinical trial.

Avicenna J Phytomed 2018 Jul-Aug;8(4):330-337

Metabolic Syndrome Research Center, Department of Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: Cholesteryl Ester Transfer Protein (CETP) mediates the transfer of cholesteryl ester from HDL-C to LDL-C and VLDL-C. The aim of the present trial was to evaluate the effect of curcumin and its modified formulation on serum CETP concentrations in patients with metabolic syndrome.

Materials And Methods: Participants were randomly allocated to one of three groups of 40 subjects receiving either unmodified curcumin or its phospholipid complex or placebo. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204148PMC
November 2018
6 Reads

Quantitative ethnobotanical appraisal of medicinal plants used by inhabitants of lower Kurram, Kurram agency, Pakistan.

Avicenna J Phytomed 2018 Jul-Aug;8(4):313-329

Department of Botany, University of Peshawar, KP, Pakistan.

Objective: Medicinal plants are used for treatment of ailments throughout rural and urban areas of the world. Such use of plants varies from one region to another and is measured using quantitative techniques. The current research which was conducted from March to October 2015, is the first explorative study of medicinal plants used by inhabitants of lower Kurram, Kurram agency, Pakistan. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204146PMC
November 2018

Cytotoxic activity of the genus (Apiaceae) and its bioactive constituents.

Avicenna J Phytomed 2018 Jul-Aug;8(4):296-312

Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran.

Objective: The genus L. includes perennial flowering plants belonging to the Apiaceae family. This genus is a rich source of biologically active phytochemicals such as sulfur-containing derivatives, coumarins, sesquiterpenes, sesquiterpene lactones, sesquiterpene coumarins, glucuronic acid, galactose, arabinose, rhamnose, and daucane esters. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204145PMC
November 2018
21 Reads

The effect of latex on 7, 12-dimethylbenz () anthracene-induced breast cancer in rats.

Avicenna J Phytomed 2018 Jul-Aug;8(4):286-295

Department of Biology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran.

Objective: In traditional medicine, (also known as fig) latex is recognized as a remedy with various therapeutic effects. Recently, studies have reported the anticancer effect of this latex on cancer cell lines. This study evaluated the effect of this latex on breast cancer growth, hematological parameters, and histopathology in rats. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204144PMC
November 2018
6 Reads

and antifungal activity of and .

Avicenna J Phytomed 2018 Sep-Oct;8(5):465-474

Department of Microbiology, Yasooj Branch, Islamic Azad University, Yasooj, Iran.

Objective: One of the major clinical problems is the resistance of species towards most of antifungals. The search for new antifungal drug from plants have helped to overcome this problem. This study evaluated the effects of and extracts on both and in a mouse model of systemic candidiasis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190248PMC
October 2018
1 Read

Protective effect of Mumiju against acetic acid-induced ulcerative colitis in rats.

Avicenna J Phytomed 2018 Sep-Oct;8(5):457-464

School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

Objective: In this study, we elucidated the ameliorative effect of aqueous extract of leaves of Mumiju against acetic acid-induced experimental colitis in male rats.

Materials And Methods: The animals were randomly divided into four groups (n=7) including I: control group, II: vehicle group (injected with 2 ml acetic acid (4%) intra rectally), III and IV: treatment groups which received Mumiju (250 mg/kg) orally or intraperitoneally for 4 consecutive days after ulcer induction. Ulcer index, severity of inflammation, colonic levels of superoxide dismutase (SOD), glutathione (GSH), and malondialdehyde (MDA), and histological changes were recorded after the treatment regimen of 4 days. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190247PMC
October 2018

Protective effects of hydro-alcoholic extract of against lead-induced oxidative stress in the reproductive system of male mice.

Avicenna J Phytomed 2018 Sep-Oct;8(5):448-456

Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.

Objective: Exposure to heavy metals such as lead (Pb) results in oxidative stress induction in the male reproductive system. Herbal medicine can be utilized as antioxidant agents against oxidative stress. (QB) has shown antioxidant activity in previous studies. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190249PMC
October 2018
11 Reads

Synergistic effects of and radiotherapy on induction of cytotoxicity in HeLa cell line.

Avicenna J Phytomed 2018 Sep-Oct;8(5):439-477

Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: Cervical cancer is the second most common type of cancer among women, worldwide; and for treatment of this type of cancer radiotherapy is commonly used. Boiss ("Barije" in Persian, from the family Apiaceae), (F. gummosa), is an extremely precious medicinal plant which naturally grows throughout the Mediterranean and Central Asia and is a native plant in Iran. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190245PMC
October 2018
13 Reads

Antimycobacterial activity of fruit of DC against .

Avicenna J Phytomed 2018 Sep-Oct;8(5):432-438

Research Center for Chemsitry - The Indonesian Institute of Sciences (LIPI). Tangerang Selatan, Banten 15314, Indonesia.

Objective: Fruits of lemon pepper ( DC., Rutaceae) have been traditionally used as a spice and in folk medicine for treatment of diarrhea and stomachache. Stomachache could be associated with mycobacterial infection. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190246PMC
October 2018

Anti-virulence potential of eugenol-rich fraction of against multidrug resistant uropathogens isolated from catheterized patients.

Avicenna J Phytomed 2018 Sep-Oct;8(5):416-431

Renal Research Lab, Centre for Bio Medical Research, School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, India.

Objective: Considering the emergence of biofilm-associated pathogens with multidrug resistance, the objective(s) of the present study was to evaluate the anti-virulence property of extracts/fractions against 2 multidrug-resistant catheter isolates.

Materials And Methods: Pulverized clove buds were subjected to bioactivity-guided isolation to identify the bioactive extract/fraction(s) with significant anti-virulence property. The clove bud powder was subjected to Soxhlet extraction and all these extracts were investigated in terms of anti-virulent efficacy using initial readout assays. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190244PMC
October 2018
14 Reads

Antiulcer effects of Boiss. on indomethacin-induced gastric ulcer in rats.

Avicenna J Phytomed 2018 Sep-Oct;8(5):408-415

Schools of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.

Objective: has been reported to have several medicinal properties including antioxidant, antibacterial, antispasmodic, and expectorant activities. This study aimed to investigate the effect of hydro-alcoholic extract (ZMHE) on peptic ulcer caused by indomethacin in rats.

Materials And Methods: ZMHE was prepared by maceration, condensed by rotary evaporator and dried by a freeze-drier. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190242PMC
October 2018
11 Reads

Effects of Rosmarinus officinalis and Platanus orientalis extracts on asthmatic subjects resistant to routine treatments.

Avicenna J Phytomed 2018 Sep-Oct;8(5):399-407

Biologist, Shahid Hasehemi Nezhad Research center, Kavosh high school, Ministry of Education, Mashhad, Iran.

Objective: The present study aimed to determine the effects of ( and () extracts on asthma.

Materials And Methods: We conducted a randomized, double-blind, active-comparator study to evaluate the effect of and extracts on asthmatic patients resistant to routine treatment. The subjects were randomly divided into three groups receiving and extracts alone or in combination. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190250PMC
October 2018
5 Reads

Effect of a functional food (vegetable soup) on blood rheology in patients with polycythemia.

Avicenna J Phytomed 2018 Sep-Oct;8(5):389-398

Department of Persian and Complementary Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: Key hemorheological variables are associated with several life-threatening diseases including cardio-cerebro-vascular diseases. A diet can influence the blood rheological variables. To compare the effectiveness of a vegetable soup on blood viscosity (BV), hematocrit (Hct), plasma fibrinogen, lipid profile, fasting blood sugar (FBS), and blood osmolarity in patients with polycythemia in comparison to a control group. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190243PMC
October 2018
3 Reads

A comparison between the effects of seeds extract and valsartan on echocardiographic and hemodynamic parameters in rats with levothyroxine-induced thyrotoxicosis.

Avicenna J Phytomed 2018 May-Jun;8(3):276-285

Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: The aim of the present study was to compare the effects of (Po) seeds extract and those of valsartan on cardiac function in levothyroxine (T)-treated rats.

Materials And Methods: Forty Wistar rats were divided into four groups (n=10): control, levothyroxine (T), T plus valsartan (T-Val) and T plus hydro-alcoholic extract of the seeds (T-Po). Control group received normal saline. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987442PMC
June 2018
6 Reads

Early and late preventive effect of on the bleomycin-induced pulmonary fibrosis in rats: An experimental study.

Avicenna J Phytomed 2018 May-Jun;8(3):263-275

Assistant Professor of Plant Protection, Department of agriculture.

Objective: Pulmonary fibhrosis is a disease of the connective tissues in the respiratory system. has been used for the treatment of pulmonary diseases like asthma. This study investigated the early and late preventive effect of methanolic extract of on a bleomycin- induced pulmonary fibrosis model. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987441PMC
June 2018
26 Reads

Protective effect of leaf hydro alcoholic extract against experimentally-induced atherosclerosis in rats.

Avicenna J Phytomed 2018 May-Jun;8(3):254-262

Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.

Objective: Finding compounds that could be used for prevention of atherosclerosis (AS) is highly desired. The present study evaluated the protective effects of (UD, commonly known as stinging nettle) leaf ethanolic extract against high-fat diet-induced AS in rats.

Materials And Methods: In this study, 40 male adult Sprauge-Dawley rats were randomly allocated to 4 equal groups and treated as follows for 9 consecutive weeks: (1) Normal control (NC; normal rats that were fed with a basic diet); (2) Atherosclerotic rats (AT; which received no particular treatment); (3) Atherosclerotic rats that received 100 mg/kg/day ethanolic extract of UD orally and (4) Atherosclerotic rats that received simvastatin 4 mg/kg/day orally. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987440PMC

evaluation of antibacterial activity of verbascoside, lemon verbena extract and caffeine in combination with gentamicin against drug-resistant and clinical isolates.

Avicenna J Phytomed 2018 May-Jun;8(3):246-253

Pharmaceutical Research Center, Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: In recent years, there has been an increasing interest in using herbal products to overcome bacterial resistance. The aim of this study was to investigate the effect of lemon verbena aqueous extract, verbascoside and caffeine in combination with gentamicin against standard and clinical isolates of and strains.

Materials And Methods: The MIC and MBC values of different antibacterial agents against bacterial strains were determined. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987439PMC
June 2018
19 Reads

induces apoptosis by increasing reactive oxygen species generation in human leukemic cells.

Avicenna J Phytomed 2018 May-Jun;8(3):237-245

Golestan Rheumatology Research Center, Golestan University of Medical Sciences, Gorgan, Iran.

Objective: or common dodder is a holoparasitic plant that has been valorized for treatment of liver injury and cancer prevention in traditional medicine. Recently, extract of had shown moderate antimicrobial properties and cytotoxic effects. In this study, we examined the level of cellular oxidants, cytotoxicity, apoptosis and differentiation induced by hydroalcoholic extract of (CCE) (12. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987438PMC

Antinociceptive effect of methanolic extract and alkaloid fractions of root in animal models.

Avicenna J Phytomed 2018 May-Jun;8(3):227-236

Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.

Objective: has antioxidant, hepato--renal protective, antibacterial, lipid lowering, anti-inflammatory and antinociceptive activities. The genus , has another member called which has not been studied for antinociceptive activity and therefore, this study was aimed to examine the antinociceptive effect of total extract and alkaloid fractions of  root in mice.

Materials And Methods: Methanolic total extract and alkaloid fractions of the plant namely, fractions A, B, C and D were prepared according to standard methods. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987437PMC
June 2018
3 Reads