13,730 results match your criteria Avian Influenza


Difference in pathogenicity of 2 strains of avian leukosis virus subgroup J in broiler chicken.

Poult Sci 2019 Feb 15. Epub 2019 Feb 15.

Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Agricultural University, 61 Daizong Street, Taian City, Shandong Province 271018, China.

Avian leukosis virus subgroup J has been found to infect many types of chickens with various genetic backgrounds. The ALV-J strain NX0101, which was isolated from broiler breeders in 2001, mainly induces the formation of myeloid cell tumors. However, strain HN10PY01, which was recently isolated from laying hens, mainly induces the formation of myeloid cell tumors and hemangioma. Read More

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http://dx.doi.org/10.3382/ps/pez065DOI Listing
February 2019

Emerging Influenza D Virus Threat: What We Know so Far!

J Clin Med 2019 Feb 5;8(2). Epub 2019 Feb 5.

Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA.

Influenza viruses, since time immemorial, have been the major respiratory pathogen known to infect a wide variety of animals, birds and reptiles with established lineages. They belong to the family and cause acute respiratory illness often during local outbreaks or seasonal epidemics and occasionally during pandemics. Recent studies have identified a new genus within the family. Read More

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http://dx.doi.org/10.3390/jcm8020192DOI Listing
February 2019

An avian influenza virus A(H7N9) reassortant that recently emerged in the United States with low pathogenic phenotype does not efficiently infect swine.

Influenza Other Respir Viruses 2019 Feb 13. Epub 2019 Feb 13.

Virus and Prion Research Unit, Agricultural Research Service, National Animal Disease Center, U.S. Department of Agriculture, Ames, Iowa.

In 2017, outbreaks of low and highly pathogenic avian H7N9 viruses were reported in four States in the United States. In total, over 270 000 birds died or were culled, causing significant economic loss. The potential for avian-to-swine transmission of the U. Read More

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http://dx.doi.org/10.1111/irv.12631DOI Listing
February 2019

H5N8 and H7N9 packaging signals constrain HA reassortment with a seasonal H3N2 influenza A virus.

Proc Natl Acad Sci U S A 2019 Feb 13. Epub 2019 Feb 13.

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322

Influenza A virus (IAV) has a segmented genome, which () allows for exchange of gene segments in coinfected cells, termed reassortment, and () necessitates a selective packaging mechanism to ensure incorporation of a complete set of segments into virus particles. Packaging signals serve as segment identifiers and enable segment-specific packaging. We have previously shown that packaging signals limit reassortment between heterologous IAV strains in a segment-dependent manner. Read More

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http://dx.doi.org/10.1073/pnas.1818494116DOI Listing
February 2019

[High expression and immunogenicity analysis of HA globular head domain of H5 subtype avian influenza virus produced in Pichia pastoris].

Sheng Wu Gong Cheng Xue Bao 2019 Jan;35(1):49-58

Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.

To evaluate the immunogenicity of HA globular head domain of H5 subtype influenza virus (H5HA), the gene of H5HA was optimized and the recombinant pPICZaA-H5HA expressing vector was constructed and transfected into Pichia pastoris. The expression of the recombinant H5HA was confirmed by SDS-PAGE and Western blotting and the results demonstrated that the recombinant H5HA (37 kDa) was highly expressed in Pichia pastoris with concentration of 0.2 mg/mL in medium. Read More

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http://dx.doi.org/10.13345/j.cjb.180142DOI Listing
January 2019

Characterization of Mouse Monoclonal Antibodies Against the HA of A(H7N9) Influenza Virus.

Viruses 2019 Feb 11;11(2). Epub 2019 Feb 11.

Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.

Many cases of human infection with the H7N9 virus have been detected in China since 2013. H7N9 viruses are maintained in chickens and are transmitted to humans at live bird markets. During circulation in birds, H7N9 viruses have accumulated amino acid substitutions in their hemagglutinin (HA), which resulted in an antigenically change in the recent H7N9 viruses. Read More

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http://dx.doi.org/10.3390/v11020149DOI Listing
February 2019

Different pathogenicity of two strains of clade 2.3.4.4c H5N6 highly pathogenic avian influenza viruses bearing different PA and NS gene in domestic ducks.

Virology 2019 Jan 15;530:11-18. Epub 2019 Jan 15.

Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 120 Neungdongro, Gwangjingu, Seoul 05029, Republic of Korea. Electronic address:

H5Nx clade 2.3.4. Read More

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http://dx.doi.org/10.1016/j.virol.2019.01.016DOI Listing
January 2019

One health insights to prevent the next HxNy viral outbreak: learning from the epidemiology of H7N9.

BMC Infect Dis 2019 Feb 11;19(1):138. Epub 2019 Feb 11.

School of Public Health, Sun Yat-sen University, Zhongshan 2nd Road, Guangzhou, 510080, Guangdong, China.

Background: With an increased incidence of viral zoonoses, there is an impetus to strengthen collaborations between public health, agricultural and environmental departments. This interdisciplinary cooperation, also known as the 'One Health' approach, has received significant support from various stakeholders. However, current efforts and policies still fall short of those needed for an effective One Health approach towards disease control and prevention. Read More

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http://dx.doi.org/10.1186/s12879-019-3752-6DOI Listing
February 2019
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[Genetic characteristic of hemagglutinin of avian influenza A (H7N9) virus in Guizhou Province in 2017].

Zhonghua Yu Fang Yi Xue Za Zhi 2019 Feb;53(2):229-232

Clinical Laboratory of Institute for Communicable Disease Control and Prevention, Guizhou Center for Disease Control and Prevention, Guiyang 550004, China.

The number of H7N9 bird flu cases was high and the situation was grim in guizhou province in 2017. To understand the molecular characteristics of the hemagglutinin gene (HA) and the risk of human infection with avian influenza virus A(H7N9) in Guizhou Province, 2017. Homology, genetic evolution and pivotal sites related to receptor binding regions, pathogenicity and potential glycosylation of 14 avian influenza viruses A(H7N9) were analyzed by a series of bioinformation softwares. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-9624.2019.02.020DOI Listing
February 2019
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Estimating Risk to Responders Exposed to Avian Influenza A H5 and H7 Viruses in Poultry, United States, 2014-2017.

Emerg Infect Dis 2019 May 17;25(5). Epub 2019 May 17.

In the United States, outbreaks of avian influenza H5 and H7 virus infections in poultry have raised concern about the risk for infections in humans. We reviewed the data collected during 2014-2017 and found no human infections among 4,555 exposed responders who were wearing protection. Read More

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http://wwwnc.cdc.gov/eid/article/25/5/18-1253_article.htm
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http://dx.doi.org/10.3201/eid2505.181253DOI Listing
May 2019
5 Reads

Shedding of clade 2.3.4.4 H5N8 and H5N2 highly pathogenic avian influenza viruses in peridomestic wild birds in the U.S.

Transbound Emerg Dis 2019 Feb 10. Epub 2019 Feb 10.

United States Department of Agriculture, National Wildlife Research Center, Fort Collins, CO, USA.

European starlings (Sturnus vulgaris), house sparrows (Passer domesticus) and rock pigeons (Columba livia) are all wild birds commonly found in large numbers in and around human dwellings and domestic livestock operations. This study evaluated the susceptibility of these species to three strains of highly pathogenic avian influenza virus (HP AIV) clade 2.3. Read More

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http://dx.doi.org/10.1111/tbed.13147DOI Listing
February 2019

Association between meteorological factors, spatiotemporal effects, and prevalence of influenza A subtype H7 in environmental samples in Zhejiang province, China.

Sci Total Environ 2019 Jan 31;663:793-803. Epub 2019 Jan 31.

Zhejiang Province Centre for Disease Control and Prevention, 3399 Binsheng Road, Binjiang District, Hangzhou, Zhejiang 310051, China. Electronic address:

Background: Human infection with the H7N9 virus has been reported recurrently since spring 2013. Given low pathogenicity of the virus in poultry, the outbreak cannot be noticed easily until a case of human infection is reported. Studies showed that the prevalence of influenza A subtype H7 in environmental samples is associated with the number of human H7N9 infection, with the latter associated with meteorological factors. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.01.403DOI Listing
January 2019
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Structural and functional definition of a vulnerable site on the hemagglutinin of highly pathogenic avian influenza A virus H5N1.

J Biol Chem 2019 Feb 8. Epub 2019 Feb 8.

Tsinghua University, China.

Most neutralizing antibodies against highly pathogenic avian influenza A virus H5N1 recognize the receptor-binding site (RBS) on the globular head domain and the stem of H5N1 hemagglutinin (HA). Through comprehensive analysis of multiple human protective antibodies, we previously identified four vulnerable sites (VS1-VS4) on the globular head domain. Among them, the VS1, occupying the opposite side of the RBS on the same HA, was defined by the epitope of antibody 65C6. Read More

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http://www.jbc.org/lookup/doi/10.1074/jbc.RA118.007008
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http://dx.doi.org/10.1074/jbc.RA118.007008DOI Listing
February 2019
2 Reads

Soluble expression, rapid purification, biological identification of chicken interferon-alpha using a thioredoxin fusion system in E. coli and its antiviral effects to H9N2 avian influenza virus.

Prep Biochem Biotechnol 2019 Feb 8:1-10. Epub 2019 Feb 8.

a Department of Microbiology , Anhui Medical University , Hefei , Anhui , P.R. China.

In this paper, we report a soluble expression based on Escherichia coli and two-step purification of a novel thioredoxin-tagged chicken interferon-α fusion protein (Trx-rChIFN-α) by using pET32a(+) expression system. The mature ChIFN-α gene was amplified by Reverse transcriptase-polymerase chain reaction (RT-PCR) and subcloned into pET-32a (+) vector prior to transformation into Rosetta (DE3) competent cells. After IPTG induction, the recombinant fusion protein was expressed efficiently in the soluble fraction. Read More

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http://dx.doi.org/10.1080/10826068.2019.1566150DOI Listing
February 2019
2 Reads

In silico thermodynamic stability of mammalian adaptation and virulence determinants in polymerase complex proteins of H9N2 virus.

J Genet Eng Biotechnol 2018 Dec 23;16(2):757-767. Epub 2018 Feb 23.

VirologyDept, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt.

The polymerase complex proteins (PB2, PB1, and PA) are responsible primarily for the replication of avian influenza virus and play an important role in virus virulence, mammalian adaptation, and interspecies transmission. In this study; eight Egyptian LPAI-H9N2 viruses isolated from apparent healthy chickens and quails from 2014 to 2016. Characterization of complete nucleotide sequences, phylogenetic and mutation analysis were carried out. Read More

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http://dx.doi.org/10.1016/j.jgeb.2018.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353722PMC
December 2018
1 Read

In silico re-assessment of a diagnostic RT-qPCR assay for universal detection of Influenza A viruses.

Sci Rep 2019 Feb 7;9(1):1630. Epub 2019 Feb 7.

National Institute of Public Health, National Reference Laboratory for Influenza, Prague, Czech Republic.

The ongoing evolution of microbial pathogens represents a significant issue in diagnostic PCR/qPCR. Many assays are burdened with false negativity due to mispriming and/or probe-binding failures. Therefore, PCR/qPCR assays used in the laboratory should be periodically re-assessed in silico on public sequences to evaluate the ability to detect actually circulating strains and to infer potentially escaping variants. Read More

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http://dx.doi.org/10.1038/s41598-018-37869-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367508PMC
February 2019
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Absence of adaptive evolution is the main barrier against influenza emergence in horses in Asia despite frequent virus interspecies transmission from wild birds.

PLoS Pathog 2019 Feb 7;15(2):e1007531. Epub 2019 Feb 7.

MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom.

Virus ecology and evolution play a central role in disease emergence. However, their relative roles will vary depending on the viruses and ecosystems involved. We combined field studies, phylogenetics and experimental infections to document with unprecedented detail the stages that precede initial outbreaks during viral emergence in nature. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007531DOI Listing
February 2019
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Full-genome characterization and genetic analysis of a H9N2 virus in commercial broilers in Iran, 2017.

Trop Anim Health Prod 2019 Feb 7. Epub 2019 Feb 7.

Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.

Since 1998, Iran's poultry industry has faced several outbreaks of low pathogenic avian influenza H9N2. Tissue samples were collected from a broiler flock with respiratory symptoms in autumn 2017. After that, virus isolation and confirmation of H9N2 using RT-PCR, sequencing, and bioinformatic analysis for all eight genes were performed. Read More

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http://dx.doi.org/10.1007/s11250-019-01809-1DOI Listing
February 2019
2 Reads

Inactivated H5 Antigens of H5N8 Protect Chickens from Lethal Infections by the Highly Pathogenic H5N8 and H5N6 Avian Influenza Viruses.

J Vet Res 2018 Dec 31;62(4):413-420. Epub 2018 Dec 31.

Laboratory of Influenza Research, Umuahia Abia State, Republic of Korea.

Introduction: Highly pathogenic Asian H5-subtype avian influenza viruses have been found in poultry and wild birds worldwide since they were first detected in southern China in 1996. Extensive control efforts have not eradicated them. Vaccination prevents such viruses infecting poultry and reduces the number lost to compulsory slaughter. Read More

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http://dx.doi.org/10.2478/jvetres-2018-0078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364154PMC
December 2018
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Broad hemagglutinin-specific memory B cell expansion by seasonal influenza virus infection reflects early-life imprinting and adaptation to the infecting virus.

J Virol 2019 Feb 6. Epub 2019 Feb 6.

David H. Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA

Memory B cells (MBCs) are key determinants of the B cell response to influenza virus infection and vaccination, but the effect of different forms of influenza antigen exposure on MBC populations has received little attention. We analyzed peripheral blood mononuclear cells and plasma collected following human H3N2 influenza infection to investigate the relationship between hemagglutinin-specific antibody production and changes in the size and character of hemagglutinin-reactive MBC populations. Infection produced increased concentrations of plasma IgG reactive to the H3 head of the infecting virus, to the conserved stalk, and to a broad chronological range of H3s consistent with original antigenic sin responses. Read More

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http://dx.doi.org/10.1128/JVI.00169-19DOI Listing
February 2019
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Corrigendum: Detecting and Predicting Emerging Disease in Poultry With the Implementation of New Technologies and Big Data: A Focus on Avian Influenza Virus.

Front Vet Sci 2018 22;5:337. Epub 2019 Jan 22.

Department of Pathobiology, University of Guelph, Guelph, ON, Canada.

[This corrects the article DOI: 10.3389/fvets.2018. Read More

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http://dx.doi.org/10.3389/fvets.2018.00337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349818PMC
January 2019
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A Novel Reassortant Avian H7N6 Influenza Virus Is Transmissible in Guinea Pigs via Respiratory Droplets.

Front Microbiol 2019 22;10:18. Epub 2019 Jan 22.

Institute of Animal Husbandry and Veterinary Sciences, Hubei Academy of Agricultural Sciences, Wuhan, China.

Since 2013, H7N9 and H5N6 avian influenza viruses (AIVs) have caused sporadic human infections and deaths and continued to circulate in the poultry industry. Since 2014, H7N6 viruses which might be reassortants of H7N9 and H5N6 viruses, have been isolated in China. However, the biological properties of H7N6 viruses are unknown. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349713PMC
January 2019
1 Read

Comparative pathogenicity of H5N6 subtype highly pathogenic avian influenza viruses in chicken, Pekin duck, and Muscovy duck.

Transbound Emerg Dis 2019 Feb 5. Epub 2019 Feb 5.

Influenza Unit Division of Transboundary Animal Diseases, National Institute of Animal Health, National Agriculture and Food Research Organization (NARO), Kannondai, Tsukuba, Ibaraki, 3050856, Japan.

In Japan during the 2016-2017 winter season, clade 2.3.4. Read More

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http://dx.doi.org/10.1111/tbed.13141DOI Listing
February 2019
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Surveillance for avian influenza viruses in wild birds at live bird markets, Egypt, 2014-2016.

Influenza Other Respir Viruses 2019 Feb 3. Epub 2019 Feb 3.

Environmental Research Division, Water Pollution Research Department, Center of Scientific Excellence for Influenza Viruses, National Research Centre (NRC), Giza, Egypt.

Aim: Egypt is the habitat for a large number of bird species and serves as a vital stopover for millions of migratory birds during their annual migration between the Palearctic and Afrotropical ecozones. Surveillance for avian influenza viruses (AIVs) is critical to assessing risks for potential spreading of these viruses among domestic poultry. Surveillance for AIV among hunted and captured wild birds in Egypt was conducted in order to understand the characteristics of circulating viruses. Read More

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http://dx.doi.org/10.1111/irv.12634DOI Listing
February 2019
1 Read
2.201 Impact Factor

Inhibitory effect of grapefruit seed extract (GSE) on avian pathogens.

J Vet Med Sci 2019 Feb 4. Epub 2019 Feb 4.

Laboratory of Animal Health, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology.

The inhibitory activities of grapefruit seed extract (GSE) on avian influenza virus (AIV), Newcastle disease virus (NDV), infectious bursal disease virus (IBDV), Salmonella Infantis (SI) and Escherichia coli (EC) were evaluated. Original GSE contained 0.24% benzalkonium chloride (BZC), however, 0. Read More

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http://dx.doi.org/10.1292/jvms.18-0754DOI Listing
February 2019
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Ultrasensitive detection of avian influenza A (H7N9) virus using surface-enhanced Raman scattering-based lateral flow immunoassay strips.

Anal Chim Acta 2019 Apr 7;1053:139-147. Epub 2018 Dec 7.

Department of Bioengineering, Guangdong Province Engineering Research Center for Antibody Drug and Immunoassay, Jinan University, Guangzhou, 510632, PR China; Institute of Food Safety and Nutrition, Jinan University, Guangzhou, 510632, PR China. Electronic address:

The development of biosensors that are portable, low-cost, and quantitative has long been sought for rapid, on-site, and timely detection of avian influenza virus (AIV). In this study, an antibody-based Raman lateral flow immunoassay strip was developed to detect AIV H7N9. This LFIA strip used a novel core-shell structure material, AuAg@AgNPs, as a Raman probe. Read More

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http://dx.doi.org/10.1016/j.aca.2018.11.056DOI Listing
April 2019
1 Read

Sensitive fluorometric determination of platelet-derived growth factor BB and avian influenza A virus DNA via dual signal amplification using the hybridization chain reaction and glucose oxidase assisted recycling.

Mikrochim Acta 2019 02 2;186(3):155. Epub 2019 Feb 2.

School of Chemistry and Environment, Guangdong Ocean University, Zhanjiang, 524088, People's Republic of China.

A method is described for fluorometric determination of platelet-derived growth factor BB (PDGF-BB) and avian influenza A (H1N1) virus DNA. It is based on the use of the hybridization chain reaction (HCR) and of glucose oxidase (GOx) assisted dual-recycling amplification. A silver coated glass slide (SCGS) serves as an ideal material for separation. Read More

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http://dx.doi.org/10.1007/s00604-019-3285-0DOI Listing
February 2019
1 Read

Continuous adaptation of the HA and NA gene of H3N2 subtypes of avian influenza virus in South China, 2017-2018.

J Infect 2019 Jan 30. Epub 2019 Jan 30.

National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control, College of Veterinary Medicine, South China Agricultural University; Key Laboratory of Zoonoses, Key Laboratory of Animal Vaccine Development, Ministry of Agriculture, Guangzhou, China; Key Laboratory of Zoonoses Prevention and Control of Guangdong Province, Guangzhou, China. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2019.01.009DOI Listing
January 2019
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Bayesian Phylogenetic Analysis of the Influenza-A virus genomes isolated in Tunisia, and Determination of Potential Recombination Events.

Mol Phylogenet Evol 2019 Jan 29. Epub 2019 Jan 29.

Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, KSA; Institut National des Sciences Appliquées et de Technologie (INSAT), Tunis, Tunisia.

The influenza-A virus (IAV) causes seasonal epidemics and presents a pandemic risk with the possibility of genetic re-assortment, allowing the emergence of new strains. The evolution of IAVes is done most often by relatively frequent re-assortment between gene segments, but the hypothesis of their evolution by recombination between RNA segments has not been justified to this date. Here, we examine this hypothesis by Bayesian phylogenetic analysis, to test if recombination events have occurred between genomic RNA segments. Read More

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http://dx.doi.org/10.1016/j.ympev.2019.01.019DOI Listing
January 2019
2 Reads

The development of a multiplex serological assay for avian influenza based on Luminex technology.

Methods 2019 Jan 30. Epub 2019 Jan 30.

Wageningen Bioveterinary Research, Houtribweg 39, 8221 RA Lelystad, the Netherlands. Electronic address:

Avian influenza (AI) is an infectious disease in birds with enormous impact on the poultry sector. AI viruses are divided into different subtypes based on the antigenicity of their surface proteins haemagglutinin (HA) and neuraminidases (NA). In birds, 16 HA subtypes and 9 NA subtypes are detected in different combinations. Read More

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http://dx.doi.org/10.1016/j.ymeth.2019.01.012DOI Listing
January 2019
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Optimising the detectability of H5N1 and H5N6 highly pathogenic avian influenza viruses in Vietnamese live-bird markets.

Sci Rep 2019 Jan 31;9(1):1031. Epub 2019 Jan 31.

VEEPH Group, Royal Veterinary College, Hatfield, United Kingdom.

Live bird markets (LBMs) are major targets for avian influenza virus (AIV) surveillance programmes. While sampling the LBM environment has become a widely used alternative to the labour-intensive sampling of live poultry, the design of surveillance programmes and the interpretation of their results are compromised by the lack of knowledge about the effectiveness of these sampling strategies. We used latent class models and a unique empirical dataset collated in Vietnamese LBMs to estimate the sensitivity and specificity of five different sample types for detecting AIVs subtypes H5N1 and H5N6: oropharyngeal duck samples, solid and liquid wastes, poultry drinking water and faeces. Read More

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http://dx.doi.org/10.1038/s41598-018-37616-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355762PMC
January 2019
1 Read

Molecular characterization and receptor binding specificity of H9N2 avian influenza viruses based on poultry-related environmental surveillance in China between 2013 and 2016.

Virology 2019 Jan 3;529:135-143. Epub 2019 Jan 3.

National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, and Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing 102206, People's Republic of China. Electronic address:

H9N2 avian influenza viruses (AIVs) have become panzootic and caused sporadic human cases since 1998. Based on the poultry-related environmental surveillance data in mainland China from 2013 to 2016, a total of 68 representative environment isolates were selected and further investigated systematically. Phylogenetic analysis indicated that Y280-like H9N2 viruses have been predominant during 2013-2016 and acquired multiple specific amino acid substitutions that might favor viral transmission from avian to mammalians. Read More

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http://dx.doi.org/10.1016/j.virol.2019.01.002DOI Listing
January 2019
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Spatial modeling for low pathogenicity avian influenza virus at the interface of wild birds and backyard poultry.

Transbound Emerg Dis 2019 Jan 30. Epub 2019 Jan 30.

Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, MN, USA.

Low pathogenicity avian influenza virus (LPAIV) is endemic in wild birds and poultry in Argentina, and active surveillance has been in place to prevent any eventual virus mutation into a highly pathogenic avian influenza virus (HPAIV), which is exotic in this country. Risk mapping can contribute effectively to disease surveillance and control systems, but it has proven a very challenging task in the absence of disease data. We used a combination of expert opinion elicitation, multicriteria decision analysis (MCDA), and ecological niche modeling (ENM) to identify the most suitable areas for the occurrence of LPAIV at the interface between backyard domestic poultry and wild birds in Argentina. Read More

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http://dx.doi.org/10.1111/tbed.13136DOI Listing
January 2019
1 Read

Heterosubtypic protection against avian influenza virus by live attenuated and chimeric norovirus P-particle-M2e vaccines in chickens.

Vaccine 2019 Jan 25. Epub 2019 Jan 25.

Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH, United States; Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, OH, United States. Electronic address:

Avian influenza in poultry continues to be a great concern worldwide, and the currently licensed inactivated influenza vaccines are not effective against the novel strains of influenza virus that continue to emerge in the field. This warrants the development of more broadly protective influenza vaccines or vaccination regimens. Live attenuated influenza vaccines (LAIVs) and subunit vaccines derived from viral peptides, such as the highly conserved ectodomain of influenza virus matrix protein 2 (M2e), can offer a more broadly reactive immune response. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X193010
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http://dx.doi.org/10.1016/j.vaccine.2019.01.037DOI Listing
January 2019
2 Reads

Digital Single Virus Immunoassay for Ultrasensitive Multiplex Avian Influenza Virus Detection Based on Fluorescent Magnetic Multifunctional Nanospheres.

ACS Appl Mater Interfaces 2019 Feb 5;11(6):5762-5770. Epub 2019 Feb 5.

Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, State Key Laboratory of Virology , Wuhan University , Wuhan 430072 , P. R. China.

The fluorescence method has made great progress in the construction of sensitive sensors but the background fluorescence of the matrix and photobleaching limit its broad application in clinical diagnosis. Here, we propose a digital single virus immunoassay for multiplex virus detection by using fluorescent magnetic multifunctional nanospheres as both capture carriers and signal labels. The superparamagnetism and strong magnetic response ability of nanospheres can realize efficient capture and separation of targets without sample pretreatment. Read More

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http://dx.doi.org/10.1021/acsami.8b18898DOI Listing
February 2019
2 Reads

A Comprehensive Review on the Interaction Between the Host GTPase Rab11 and Influenza A Virus.

Front Cell Dev Biol 2018 9;6:176. Epub 2019 Jan 9.

Cell Biology of Viral Infection Lab, Instituto Gulbenkian de Ciência, Oeiras, Portugal.

This year marks the 100th anniversary of one of the deadliest pandemic outbreaks, commonly referred as the Spanish Flu, that was caused by influenza A virus (IAV). Since then, IAV has been in governmental agendas worldwide, and a lot of effort has been put into understanding the pathogen's lifecycle, predict and mitigate the emergence of the strains that provoke yearly epidemics and pandemic events. Despite decades of research and seminal contributions there is still a lot to be investigated. Read More

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http://dx.doi.org/10.3389/fcell.2018.00176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333742PMC
January 2019
1 Read

Avian H5N1 influenza virus infection causes severe pneumonia in the Northern tree shrew (Tupaia belangeri).

Virology 2019 Jan 19;529:101-110. Epub 2019 Jan 19.

Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, 2-1-6, Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan. Electronic address:

Avian-origin influenza viruses like H5N1 and H7N9 often cause severe symptoms with high mortality in humans. Animal models are useful for clarification of the mechanisms of pathogenicity of these infections. In this study, to expand the potential utility of the Northern tree shrew (Tupaia belangeri) for influenza virus infection, we assessed the pathogenicity of H5N1 and H7N9 avian influenza viruses in tupaia. Read More

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http://dx.doi.org/10.1016/j.virol.2019.01.015DOI Listing
January 2019
2 Reads

Clinical indices and mortality of hospitalized avian influenza A (H7N9) patients in Guangdong, China.

Chin Med J (Engl) 2019 Feb;132(3):302-310

Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong 510080, China.

Background: Six epidemic waves of human infection with avian influenza A (H7N9) virus have emerged in China with high mortality. However, study on quantitative relationship between clinical indices in ill persons and H7N9 outcome (fatal and non-fatal) is still unclear. A retrospective cohort study was conducted to collect laboratory-confirmed cases with H7N9 viral infection from 2013 to 2015 in 23 hospitals across 13 cities in Guangdong Province, China. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000043DOI Listing
February 2019
5 Reads
1.016 Impact Factor

Establishment of sandwich ELISA for detecting the H7 subtype influenza A virus.

J Med Virol 2019 Jan 24. Epub 2019 Jan 24.

National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health Commission, Beijing, P. R. China.

Avian H7N9 subtype influenza virus infects human with high case-fatality rate since it emerged in 2013. Although the vaccination has been rapidly used in poultry due to the emergence of highly pathogenic strain, this virus remains prevalent in this region. Thus, rapid diagnosis both in poultry and human clinic is critically important for the control and prevention of H7N9 infection. Read More

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http://dx.doi.org/10.1002/jmv.25408DOI Listing
January 2019
1 Read

[Baloxavir marboxil: a potent cap-dependent endonuclease inhibitor of influenza viruses].

Authors:
J Reina N Reina

Rev Esp Quimioter 2019 Feb 23;32(1):1-5. Epub 2019 Jan 23.

Jordi Reina, Unidad de Virología, Servicio de Microbiología, Hospital Universitario Son Espases, Palma de Mallorca. Spain.

Baloxavir marboxil (5-hydroxy-4-pyridone-3-carboxyl acid) is a new antiviral drug with special efficacy on influenza viruses that acts by inhibiting the cap-dependent endonuclease required for its replication. It is the first representative of the so-called inhibitors of influenza-like PB2. It has shown efficacy against influenza viruses A and B and most strains of animal origin (avian flu). Read More

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February 2019
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Characterization of a novel reassortant H7N3 highly pathogenic avian influenza virus isolated from a poultry meat product taken on a passenger flight to Japan.

J Vet Med Sci 2019 Jan 24. Epub 2019 Jan 24.

Exotic Disease Inspection Division, Laboratory Department, Animal Quarantine Service, Ministry of Agriculture, Forestry and Fisheries.

A new reassortant H7N3 avian influenza virus (AIV) was isolated from a duck meat product that was illegally taken on board a passenger flight from China to Japan in March 2018. Sequencing analysis revealed that the H7N3 isolate, A/duck/Japan/AQ-HE30-1/2018 (Dk/HE30-1) (H7N3), was a reassortant highly pathogenic avian influenza virus (HPAIV) that contained the haemagglutinin (HA) gene of Chinese H7N9 HPAIV. Dk/HE30-1 (H7N3) possessed a novel polybasic sequence motif PEVPKRRRTAR/GLF at the HA cleavage site that has never previously been reported in H7 HPAIVs. Read More

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http://dx.doi.org/10.1292/jvms.18-0628DOI Listing
January 2019
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The cellular localization of avian influenza virus PB1-F2 protein alters the magnitude of IFN2 promoter and NFκB-dependent promoter antagonism in chicken cells.

J Gen Virol 2019 Jan 23. Epub 2019 Jan 23.

1​The Pirbright Institute, Pirbright, Woking, UK.

The accessory protein, PB1-F2, of influenza A virus (IAV) functions in a chicken host to prolong infectious virus shedding and thus the transmission window. Here we show that this delay in virus clearance by PB1-F2 in chickens is accompanied by reduced transcript levels of type 1 interferon (IFN)-induced genes and NFκB-activated pro-inflammation cytokines. In vitro, two avian influenza isolate-derived PB1-F2 proteins, H9N2 UDL01 and H5N1 5092, exhibited the same antagonism of the IFN and pro-inflammation induction pathways seen in vivo, but to different extents. Read More

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http://dx.doi.org/10.1099/jgv.0.001220DOI Listing
January 2019
2 Reads

Recombinant baculovirus vaccine expressing hemagglutinin of H7N9 avian influenza virus confers full protection against lethal highly pathogenic H7N9 virus infection in chickens.

Arch Virol 2019 Jan 22. Epub 2019 Jan 22.

Animal Infectious Disease Laboratory, School of Veterinary Medicine, Yangzhou University, 48 East Wenhui Road, Yangzhou, Jiangsu, 225009, China.

The emergent highly pathogenic avian influenza A (H7N9) (HPAI) virus is a major public concern in China. Therefore, it is crucially important to develop an effective vaccine against this virus. In this study, we constructed a baculovirus vaccine expressing the hemagglutinin (HA) of H7N9 strain A/Chicken/Jiaxing/148/2014 (JX148). Read More

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http://link.springer.com/10.1007/s00705-018-04142-4
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http://dx.doi.org/10.1007/s00705-018-04142-4DOI Listing
January 2019
4 Reads

PADI-web corpus: Labeled textual data in animal health domain.

Data Brief 2019 Feb 23;22:643-646. Epub 2018 Dec 23.

TETIS, Univ. of Montpellier, AgroParisTech, Cirad, CNRS, Irstea, Montpellier, France.

Monitoring animal health worldwide, especially the early detection of outbreaks of emerging pathogens, is one of the means of preventing the introduction of infectious diseases in countries (Collier et al., 2008) [3]. In this context, we developed PADI-web, a Platform for Automated extraction of animal Disease Information from the Web (Arsevska et al. Read More

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http://dx.doi.org/10.1016/j.dib.2018.12.063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327737PMC
February 2019
1 Read

Developing Farm-Level Post-vaccination Sero-Monitoring Systems for H5N1 Highly Pathogenic Avian Influenza in an Endemically Infected Country.

Front Vet Sci 2018 8;5:324. Epub 2019 Jan 8.

Faculty of Veterinary Science, University of Melbourne, Melbourne, VIC, Australia.

Whilst the serological responses of poultry following vaccination against highly pathogenic avian influenza H5N1 has been extensively investigated under laboratory conditions, there have been fewer studies conducted in the field. This applies particularly to the endemically infected countries routinely practicing vaccination, where the combination of multiple circulating clades and/or the use of vaccines with different seed strains makes the design and interpretation of field studies especially problematic. To address this for the particular situation of layer hens in the small to medium commercial sector in Indonesia, we developed a sampling regime before and after the vaccination given to point-of-lay pullets, and assessed serological response with a panel of test antigens. Read More

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https://www.frontiersin.org/article/10.3389/fvets.2018.00324
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http://dx.doi.org/10.3389/fvets.2018.00324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331391PMC
January 2019
3 Reads

Individual and flock immunity responses of naïve ducks on smallholder farms after vaccination with H5N1 Avian Influenza vaccine: a study in a province of the Mekong Delta, Vietnam.

PeerJ 2019 16;7:e6268. Epub 2019 Jan 16.

Veterinary Public Health Centre for Asia Pacific (VPHCAP) and Excellent Center of Veterinary Public Health, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai, Thailand.

In Vietnam, vaccination has played a crucial role in the national strategy for the prevention and control of H5 highly pathogenic avian influenza (HPAI). This study aimed to evaluate antibody responses of immunologically naïve domestic ducks to H5N1 avian influenza vaccine currently used in the national mass vaccination program of Vietnam. Blood samples of 166 ducks reared on smallholder farms were individually collected at three sampling time points, namely, right before vaccination, 21 days after primary vaccination, and 21 days after booster vaccination. Read More

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https://peerj.com/articles/6268
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http://dx.doi.org/10.7717/peerj.6268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339474PMC
January 2019
8 Reads

Preliminary results on the uptake and biochemical response to water-exposure of Tamiflu® (oseltamivir phosphate) in two marine bivalves.

J Toxicol Environ Health A 2019 Jan 22:1-11. Epub 2019 Jan 22.

a Institute of Marine Sciences (ICM-CSIC) , Barcelona , Spain.

Tamiflu® (oseltamivir phosphate, OST) is an antiviral drug used for the pandemic treatment of avian influenza but few data are available regarding its toxicity. It should be noted that acute adverse responses are not likely to occur due to low environmental presence of this drug. Nonetheless, water concentration levels of this compound may reach the µg/L range under influenza episodes. Read More

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http://dx.doi.org/10.1080/15287394.2018.1562393DOI Listing
January 2019
2 Reads

Co-infections, genetic, and antigenic relatedness of avian influenza H5N8 and H5N1 viruses in domestic and wild birds in Egypt.

Poult Sci 2019 Jan 22. Epub 2019 Jan 22.

Poultry Diseases Department, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef 62511, Egypt.

A total of 50 poultry farms of commercial broilers (N = 39) and commercial layers (N = 11) suffered from respiratory problems and mortality during the period from January 2016 to December 2017 were investigated. Also, samples were collected from quail (N = 4), Bluebird (Sialis, N = 1), and Greenfinch (Chloris chloris, N = 1) for analysis. Respiratory viral pathogens were screened by PCR and positive samples were subjected to virus isolation and genetic identification. Read More

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http://dx.doi.org/10.3382/ps/pez011DOI Listing
January 2019
1 Read
1.672 Impact Factor

Comparison between human infections caused by highly and low pathogenic H7N9 avian influenza viruses in Wave Five: Clinical and virological findings.

J Infect 2019 Jan 18. Epub 2019 Jan 18.

Shenzhen Key Laboratory of Pathogen and Immunity, Guangdong Key Laboratory for Diagnosis and Treatment of Emerging Infectious Diseases, State Key Discipline of Infectious Disease, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen Third People's Hospital, Shenzhen 518112, China; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, Institute of Microbiology, Center for Influenza Research and Early-Warning (CASCIRE), Chinese Academy of Sciences, Beijing 100101, China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 102206, China; University of Chinese Academy of Sciences Medical School, Chinese Academy of Sciences, Beijing 101408, China. Electronic address:

Objective: The newly emerged highly pathogenic (HP) H7N9 avian influenza virus during Wave Five has caused 28 human infections, while differences in disease severity between low pathogenic (LP)- and HP-H7N9 human infections remain unclear.

Methods: Clinical data, concentrations of serum cytokines, dynamics of virus shedding and PaO/FiO from patients infected with LP-H7N9 (n = 7, LP group) and HP-H7N9 (n = 5, HP group) viruses during Wave Five were compared. In addition, critical mutations associated with H7N9 virulence in mammal/human were analyzed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01634453193002
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http://dx.doi.org/10.1016/j.jinf.2019.01.005DOI Listing
January 2019
5 Reads
4.441 Impact Factor