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Eur Rev Med Pharmacol Sci 2022 Jun;26(12):4197-4206

Department of Orthopedics, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, People's Republic of China.

Objective: The aim of this paper was to evaluate the effects of robot-assisted core decompression combined with human umbilical cord-derived mesenchymal stem cell (hUC-MSC) transplantation for early-stage osteonecrosis of the femoral head (ONFH).

Patients And Methods: A retrospective analysis was performed on 18 patients with a total of 26 hips who were diagnosed with Association Research Circulation Osseous stage 2 avascular necrosis of the femoral head and who received core decompression combined with hUC-MSC transplantation. All surgeries were completed under robotic assistance. Read More

Ulus Travma Acil Cerrahi Derg 2022 Jul;28(7):1008-1015

Department of Orthopedics and Traumatology, Haydarpasa Numune Training and Research Hospital, İstanbul-Türkiye.

Background: In proximal humerus fractures, loss of reduction can occur following surgical fixation. The factors that affect loss of reduction in cases treated with locking plates as well as their relationship with the degree of loss of reduction were investigated in this study.

Methods: The study included 48 patients who underwent surgical treatment with a locking plate for a displaced proximal humerus fracture and experienced loss of reduction during follow-up. Read More

Zhonghua Wai Ke Za Zhi 2022 Jul;60(7):703-708

Department of Orthopedics,the Affiliated Hospital of Qingdao University,Qingdao 266000,China.

To investigate the long-term outcomes of minimally invasive Oxford phase Ⅲ unicompartmental knee arthroplasty (UKA) for patients with medial compartment osteoarthropathy. The clinical data of 594 patients (701 knees) who underwent minimally invasive UKA with Oxford phase Ⅲ unicompartmental prosthesis at Department of Orthopedics,the Affiliated Hospital of Qingdao University from January 2007 to January 2016 were retrospectively analyzed.There were 155 males and 439 females,aged (62. Read More

Bone Joint J 2022 Jul;104-B(7):902-908

Department of Orthopaedic Surgery, National Taiwan University Hospital, Taipei, Taiwan.

Aims: The aim of this study was to compare outcomes of guided growth and varus osteotomy in treating Kalamchi type II avascular necrosis (AVN) after open reduction and Pemberton acetabuloplasty for developmental dysplasia of the hip (DDH).

Methods: This retrospective study reviewed patients undergoing guided growth or varus osteotomy for Kalamchi type II AVN between September 2009 and January 2019. All children who had undergone open reduction and Pemberton acetabuloplasty for DDH with a minimum two-year follow-up were enrolled in the study. Read More

Orthop Rev (Pavia) 2022 25;14(3):33639. Epub 2022 Apr 25.

Medical direction, San Pier Damiano Hospiatl, GVM care and research, Faenza (RA), Italy.

Knee osteonecrosis is a debilitating progressive degenerative disease characterized by subchondral bone ischemia. It can lead to localized necrosis, tissue death, and progressive joint destruction. For this reason, it is essential to diagnose and treat this disease early to avoid subchondral collapse, chondral damage, and end-stage osteoarthritis, where the only solution is total knee arthroplasty. Read More

Cureus 2022 May 26;14(5):e25348. Epub 2022 May 26.

Trauma and Orthopaedics, Huddersfield Royal Infirmary, Huddersfield, GBR.

Introduction The management of proximal humeral fractures ranges greatly from conservative management to surgical treatment. For those fractures requiring surgical treatment, internal fixation is the primary method. The aim of internal fixation is to achieve rigid fracture fixation until union occurs, return of shoulder range of motion, and minimise intra-and postoperative complications. Read More

Gene 2022 Jun 27:146705. Epub 2022 Jun 27.

The Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin 150000, Heilongjiang, China.

Although the precise pathogenesis of steroid-induced osteonecrosis of femoral head (SONFH) is not yet fully understood, evidence shows miRNAs-mediated posttranscription control directs the adipogenesis of bone marrow mesenchymal stem cells (BMSCs) and plays a pivotal role in the SONFH processes. Huogu injection formulated according to traditional Chinese medicine (TCM) theory has been used to treat SONFH by intra-articular injection. In this study, we asked whether the therapeutic effects of Huogu injection might depend on the inhibition of adipogenic differentiation of BMSCs, and if so, the pathway might be a therapeutic target to promote bone repair. Read More

Oral Oncol 2022 Jun 27;132:105974. Epub 2022 Jun 27.

Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address:

SICOT J 2022 29;8:29. Epub 2022 Jun 29.

Department of Pediatric Orthopedic and Traumatology, University Hospital Hassan II - Sidi Mohamed Ben Abdellah University - The Faculty of Medicine and Pharmacy of Fez, Boite Postale 1893 - KM 2.200 Route, Sidi Harazem Fès 30070, Morocco.

Introduction: No consensus exists about the open reduction of developmental dysplasia of the hip (DDH; age of surgery and the need for additional bone surgery). We report clinical and radiological outcomes of a large monocentric study. The objectives are to analyze outcomes and to give recommendations. Read More

Orthop Rev (Pavia) 2022 31;14(4):35446. Epub 2022 May 31.

2nd Academic Department of Orthopedic Surgery, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, General Hospital of Thessaloniki "G. Gennimatas", Greece.

Background: The purpose of this study is to compare the vascularized bone flaps (VBF) that are used in operations for scaphoid non-union in smokers and non-smokers and to scrutinize if the better biological potential of the VBFs can counteract the negative influence of smoking on healing.

Materials And Methods: Our study included articles published until 2016, with scaphoid non-union patients who were operated on with a VBF or a VBG.

Results: Eighteen articles met eligibility criteria with 335 non-smokers and 136 smokers totally. Read More

Int J Stem Cells 2022 Jun 30. Epub 2022 Jun 30.

Department of Emergency and Trauma Surgery, People's Hospital of Pingxiang, Pingxiang, China.

Background And Objectives: This study was to investigate the role of microRNA-29a-3p (miR-29a-3p) in human bone marrow mesenchymal stem cells (hBMSCs), and its relationship with steroid-associated osteonecrosis.

Methods And Results: The online tool GEO2R was used to screen out the differentially expressed genes (DEGs) in GSE123568 dataset. Quantitative real time-polymerase chain reaction (qRT-PCR) was performed to detect the expression of miR-29a-3p, forkhead box O3 (FOXO3), alkaline phosphatase (ALP), bone gamma-carboxyglutamate protein (OCN) and RUNX family transcription factor 2 (Runx2) in the hBMSCs isolated from the patients with steroid- associated osteonecrosis. Read More

Clin Orthop Relat Res 2022 Jun 21. Epub 2022 Jun 21.

Department of Surgery, Sint-Antonius Ziekenhuis, Nieuwegein, Utrecht, the Netherlands.

Background: Femoral neck fractures are common and are frequently treated with internal fixation. A major disadvantage of internal fixation is the substantially high number of conversions to arthroplasty because of nonunion, malunion, avascular necrosis, or implant failure. A clinical prediction model identifying patients at high risk of conversion to arthroplasty may help clinicians in selecting patients who could have benefited from arthroplasty initially. Read More

PLoS One 2022 29;17(6):e0270569. Epub 2022 Jun 29.

Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Background: Although vitamin D concentration is reportedly associated with the pathogenesis and pathology of systemic lupus erythematosus (SLE), benefits of vitamin D supplementation in SLE patients have not been elucidated, to our knowledge. We investigated the clinical impacts of vitamin D supplementation in SLE.

Methods: A cross-sectional analysis was performed using data from a lupus registry of nationwide institutions. Read More

Clin Rheumatol 2022 Jun 28. Epub 2022 Jun 28.

Department of Orthopedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1, Shuaifuyuan Wangfujing, Dongcheng District, Beijing, 100730, China.

Introduction: The number of patients with primary Sjögren's syndrome (PSS) requiring total hip arthroplasty (THA) is expected to increase, but few studies have detailed their outcomes. The purpose of this study was to evaluate a THA cohort of patients with avascular necrosis of the femoral head (ANFH) who had PSS and to compare their outcomes with those of matched patients with osteoarthritis.

Method: A case-control study using data from a single-institution arthroplasty registry was performed. Read More

Int Orthop 2022 Jun 28. Epub 2022 Jun 28.

Postgraduate Program of the Instituto de Assistência Médica ao Servidor Público Estadual (IAMSPE), São Paulo, SP, Brazil.

Purpose: This study investigated the incidence of AVN in patients with cerebral palsy who underwent a hip reconstruction surgery (soft tissue release, femur and pelvic osteotomies) and its impact on quality of life.

Methods: Retrospective study, with clinical and radiographic analysis of 104 patients (128 hips) GMFCS IV and V with a minimum two year follow-up. Reimers migration percentage, the amount of abduction, acetabular index, and the neck-shaft angle were collected before and after surgery. Read More

Medicine (Baltimore) 2022 Jun 24;101(25):e29436. Epub 2022 Jun 24.

Department of Orthopedic Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.

Abstract: Breakage of the intramedullary nail is a rare complication after proximal femoral nail antirotation (PFNA) in intertrochanteric fracture treatment. The purpose of this study was (1) to investigate the frequency of nail breakage among the patients who were treated for mechanical failure after PFNA for intertrochanteric/pertrochanteric fracture, and (2) to determine the risk factors for nail breakage in PFNA treatment of intertrochanteric fracture.To identify mechanical failure after internal fixation using PFNA, we retrospectively reviewed the data of 35 patients (35 hips) who required reoperation after PFNA with a helical blade for intertrochanteric/pertrochanteric fracture between June 2005 and June 2018. Read More

J Belg Soc Radiol 2022 9;106(1):55. Epub 2022 Jun 9.

Cliniques Universitaires Saint Luc, BE.

Aim: To assess the frequency of bone changes in resected osteonecrotic femoral head (ONFH) specimens at multidetector computed tomography (MDCT) and compare their frequencies between ONFH with limited or advanced collapse.

Method: Fourteen ONFH were imaged using MDCT (n = 14) and microcomputed tomography ([µCT]; n = 8). Preoperative staging was performed using radiographs and MRI. Read More

Front Oral Health 2022 9;3:907778. Epub 2022 Jun 9.

Department of Orofacial Sciences, University of California, San Francisco, San Francisco, CA, United States.

The number of cancer survivors are increasing and so are the oral toxicities from cancer therapy. Most patients receiving treatment for cancer develop some form of oral adverse events including, but not limited to, mucositis, opportunistic infections, dry mouth, and/or osteonecrosis of the jaw. One of the most common complications from head and neck cancer radiation therapy is salivary gland dysfunction (SGD). Read More

J Dent Sci 2022 Apr 2;17(2):1066-1068. Epub 2021 Dec 2.

Department of Molecular Oral Medicine and Maxillofacial Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

J Clin Orthop Trauma 2022 Jul 11;30:101917. Epub 2022 Jun 11.

Department of Orthopaedics, Southport and Ormskirk NHS Trust, Southport, PR8 6PN, UK.

Purpose: Femoral neck fractures (FNF) in adults are conventionally managed with surgical options. This paper is aimed to assess the safety, and functional outcomes of the novel Femoral neck system (FNS) for FNF treatment in adult population.

Methods: An organized quest of four literature databases (PubMed, Scopus, Web of Science, and Cochrane Library) was performed on March 1, 2022 using the term "femoral neck system". Read More

Cureus 2022 May 23;14(5):e25255. Epub 2022 May 23.

Department of Orthopaedics and Traumatology, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, IND.

Epidural anaesthesia (EA) has consistently been used for treatments affecting the pelvis, lower limbs, lower abdomen, and perineum; however, it is progressively employed as a single anaesthetic or supplement to general and spinal anaesthesia for a broader range of procedures. The retention of a broken epidural catheter piece is an uncommon but well-known complication. In this report, we present a 30-year-old male with avascular necrosis (AVN) of the hip who was referred for total hip replacement (THR). Read More

J Bone Miner Res 2022 Jun 25. Epub 2022 Jun 25.

Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

Front Biosci (Landmark Ed) 2022 Jun;27(6):181

State Key Laboratory of Natural Medicines, China Pharmaceutical University, 210009 Nanjing, Jiangsu, China.

Background: Avascular necrosis of the femoral head (AVNFH) is a progressive, multifactorial, and challenging clinical disease that causes hip pain and loss of hip joint function. Till now, the pathogenesis of AVNFH was not fully understood. In this study, we characterized cartilage protein profiles of patients with AVNFH and identified the potential proteins involved in the progress of AVNFH using proteomics technique. Read More

Medicina (Kaunas) 2022 Jun 14;58(6). Epub 2022 Jun 14.

Digestive Surgery Clinic, University Clinical Center Nis, University of Nis, 18000 Nis, Serbia.

Extra-abdominal manifestations of fat necrosis, like subcutaneous fat necrosis, polyarthritis, and polyserositis may appear with an occurrence rate of about 0.8%, wherein intraosseous fat necrosis is a more rare complication of pancreatitis, with few reports in English literature. A 34-year-old male with a 15-year-history of alcohol abuse was hospitalized several times in the last few years because of attacks of relapsed chronic pancreatitis. Read More

J Clin Med 2022 Jun 14;11(12). Epub 2022 Jun 14.

Department of General Surgery and Medical-Surgical Specialties, Section of Orthopaedics and Traumatology, A.O.U. Policlinico Rodolico-San Marco, University of Catania, 95123 Catania, Italy.

Background: Scaphoid fractures correspond to 60% of all carpal fractures, with a risk of 10% to progress towards non-union. Furthermore, ~3% present avascular necrosis (AVN) of the proximal pole, which is one of the main complications related to the peculiar vascularization of the bone. Scaphoid non-union can be treated with vascularized and non-vascularized bone grafting. Read More

Int J Environ Res Public Health 2022 Jun 17;19(12). Epub 2022 Jun 17.

Department of Clinical Oral Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8588, Japan.

Although maxillary sinusitis often occurs in patients with medication-related osteonecrosis of the jaw (MRONJ) of the upper jaw, there have been few reports on the treatment and outcomes for maxillary sinusitis associated with maxillary MRONJ. This study aimed to retrospectively investigate the treatment outcomes of maxillary sinusitis in patients with MRONJ of the upper jaw. There were 34 patients diagnosed with maxillary MRONJ and sinusitis by preoperative computed tomography who underwent surgery in our institution between January 2011 and December 2019. Read More

Int J Environ Res Public Health 2022 Jun 15;19(12). Epub 2022 Jun 15.

Faculty of Medicine, Collegium Medicum, Cardinal Stefan Wyszynski University in Warsaw, Woycickiego 1/3, 01-938 Warsaw, Poland.

Avascular necrosis (AVN) of the femoral head is caused by disruption of the blood supply to the proximal femur. The alterations in the blood supply may occur following a traumatic event or result from a non-traumatic cause. Femoral neck fracture and hip dislocation and associated surgical procedures, corticosteroid therapy, and alcohol abuse frequently lead to AVN development. Read More

Healthcare (Basel) 2022 Jun 8;10(6). Epub 2022 Jun 8.

Department of Morphological Sciences, Carol Davila University of Medicine and Pharmacy, RO-020021 Bucharest, Romania.

Osteochondral lesions (OCLs) that are frequently encountered in skeletally immature and adult patients are more common than once thought, and their incidence rate is rising. These lesions can appear in many synovial joints of the body, such as the shoulder, elbow, hip, and ankle, occurring most often in the knee. The term osteochondral lesion includes a vast spectrum of pathologies such as osteochondritis dissecans, osteochondral defects, osteochondral fractures, and osteonecrosis of the subchondral bone. Read More

Cells 2022 06 14;11(12). Epub 2022 Jun 14.

Department of Orthopedics, Graduate School of Peking Union Medical College, China-Japan Friendship Institute of Clinical Medicine, Beijing 100000, China.

Glucocorticoids could induce injury and apoptosis of bone microvascular endothelial cells (BMECs) in the femoral head, which is associated with the development of osteonecrosis and osteoporosis. Icariin is a prenylated flavonol glycoside isolated from Epimedium brevicornum, serving as the main active pharmaceutical constituent to treat bone loss. Currently, the impact of the autocrine activity of extracellular vesicles (EVs) induced by icariin on the glucocorticoid-induced injury of BMECs is still to be confirmed. Read More

Oral Maxillofac Surg 2022 Jun 24. Epub 2022 Jun 24.

Department of Stomatology, Post Graduate Program in Dentistry, Federal University of Paraná, Avenida Professor Lothário Meissner, 623, Jardim Botânico, Curitiba/PR, Brazil.

Introduction: Medication-related osteonecrosis of the jaws (MRONJ) is a complication that develops in patients who use or have used antiresorptive or antiangiogenic medications for the treatment of bone metabolic disease and bone metastases. Clinically, MRONJ is characterized by the appearance of an inflammation in soft tissues and exposure of necrotic bone tissue in mandible or maxilla, for a period of 8 weeks, in patients with no history of head and neck radiotherapy that were being or are being treated with antiresorptive and/or antiangiogenic agents. The fibrin-rich platelets and leukocytes (L-PRF) membrane has been used as an alternative for MRONJ prevention. Read More