21,761 results match your criteria Avascular Necrosis


Changes in Human Foetal Osteoblasts Exposed to the Random Positioning Machine and Bone Construct Tissue Engineering.

Int J Mol Sci 2019 Mar 18;20(6). Epub 2019 Mar 18.

Osteoimmunology and Integrative Physiology Laboratory, Department of Biology, Texas Southern University, Cleburne, Houston, TX 77004, USA.

Human cells, when exposed to both real and simulated microgravity (s-µ), form 3D tissue constructs mirroring in vivo architectures (e.g., cartilage, intima constructs, cancer spheroids and others). Read More

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http://dx.doi.org/10.3390/ijms20061357DOI Listing

An exploratory study of articular cartilage and subchondral bone reconstruction with bone marrow mesenchymal stem cells combined with porous tantalum/Bio-Gide collagen membrane in osteonecrosis of the femoral head.

Mater Sci Eng C Mater Biol Appl 2019 Jun 19;99:1123-1132. Epub 2019 Feb 19.

Department of Orthopedics, Zhongshan Hospital of Dalian University, No. 6 Jiefang Street, Dalian, Liaoning, China; Department of Biomedical Engineering, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, Linggong Road, Dalian, China. Electronic address:

Osteonecrosis of the femoral head (ONFH) results in collapse of the femoral head and rapid destruction of the hip joint. The repair of post-collapse articular cartilage and subchondral bone is challenging. We interrupted the blood supply to the femoral head and established a full-thickness articular defect animal model after ONFH was determined via X-ray. Read More

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http://dx.doi.org/10.1016/j.msec.2019.02.072DOI Listing

Interferon gamma-1b does not increase markers of bone resorption in autosomal dominant osteopetrosis.

J Bone Miner Res 2019 Mar 19. Epub 2019 Mar 19.

Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.

In autosomal dominant osteopetrosis type 2 (ADO2) CLCN7 mutations cause impaired osteoclast function. Severe consequences include skeletal fragility despite high bone mass, osteomyelitis, osteonecrosis, bone marrow failure, and severe cranial nerve impingement. There is no effective medical treatment for ADO2. Read More

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http://dx.doi.org/10.1002/jbmr.3715DOI Listing

Epidemiology and Perioperative Complications in Patients With Sickle Cell Disease After Orthopaedic Surgery: 26 Years' Experience at a Major Academic Center.

J Am Acad Orthop Surg 2019 Mar 11. Epub 2019 Mar 11.

From the Department of Orthopaedic Surgery (Mr. Cusano, Ms. Curry, Dr. Kingston, Dr. Li), Boston University School of Medicine, and the Center of Excellence in Sickle Cell Disease (Dr. Klings), Boston University School of Medicine, Boston, MA.

Introduction: Surgical management of patients with sickle cell disease (SCD) poses a unique challenge to orthopaedic surgeons due to increased operative and perioperative risk. Studies evaluating perioperative complications among patients with SCD undergoing orthopaedic surgery have been limited. We sought to review the clinical characteristics and perioperative complications in our patients with SCD who required orthopaedic surgery. Read More

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http://dx.doi.org/10.5435/JAAOS-D-18-00288DOI Listing

Perioperative management of renal transplant patients undergoing total joint arthroplasty.

J Perioper Pract 2019 Mar 19:1750458919835435. Epub 2019 Mar 19.

Division of Trauma & Orthopaedics Surgery, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.

The success of renal transplantation depends on lifelong immunosuppression. This can lead to a high incidence of avascular necrosis of major joints in the body for which arthroplasty is the treatment of choice. The risk of surgical complications is high in these patients, and there is no current set of cohesive perioperative management guidelines. Read More

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http://dx.doi.org/10.1177/1750458919835435DOI Listing

[Avascular necrosis of femoral head - Do we always need arthroplasty?]

MMW Fortschr Med 2019 Mar;161(5):56-59

ARCUS Sportklinik, Rastatterstr. 17-19, D-75179, Pforzheim, Deutschland.

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https://www.springermedizin.de/doi/10.1007/s15006-019-0275-4
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http://dx.doi.org/10.1007/s15006-019-0275-4DOI Listing
March 2019
1 Read

A new method for the assessment of reduction tension during open reduction in patients with developmental dysplasia of the hip.

Eklem Hastalik Cerrahisi 2019 Apr;30(1):38-45

Department of Orthopedics and Traumatology, Bağcılar Training and Research Hospital, 34100 Bağcılar, İstanbul, Turkey.

Objectives: This study aims to describe our standardized method for evaluating the tension of reduction around the hip joint during open reduction in patients with developmental dysplasia of the hip (DDH).

Patients And Methods: We retrospectively evaluated 67 pediatric patients (8 males, 59 females; mean age 21.9±11. Read More

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http://dx.doi.org/10.5606/ehc.2019.61744DOI Listing

[Comparison between pathology and computer for quantitative determination of femoral head necrosis].

Zhongguo Gu Shang 2019 Feb;32(2):146-150

Department of Orthopaedics, the Second Affiliated Hospital of Zhejiang Traditional Chinese Medicine University, Hangzhou 310005, Zhejiang, China;

Objective: To compare computer measurement semi automatic quantitative detection software system with ultra thin layer pathological section to confirm the avascular necrosis percentage of the femoral head, and provide reference for clinical treatment options.

Methods: From June 2012 to December 2013, the X-ray and MRI of 24 patients(24 hips on unilateral) were reviewed, who had avascular necrosis of the femoral head at late stage (stage III and IV) according to the ARCO international staging system, and performed by total hip arthroplasty. There were 15 males and 9 females, with an average age of (65. Read More

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http://dx.doi.org/10.3969/j.issn.1003-0034.2019.02.010DOI Listing
February 2019

A Newly Modified Salter Osteotomy Technique for Treatment of Developmental Dysplasia of Hip That Is Associated with Decrease in Pressure on Femoral Head and Triradiate Cartilage.

Biomed Res Int 2019 6;2019:6021271. Epub 2019 Feb 6.

Student Research Committee, School of Medicine, Babol University of Medical Sciences, Babol, Iran.

Background And Purpose: The Salter innominate osteotomy has been an effective method to treat the developmental dysplasia of hip (DDH) over the past decades; however, several postoperative complications and deficiencies were reported. In this study, we evaluated outcome of a newly modified Salter osteotomy in patients presenting with DDH.

Methods: We reviewed retrospectively 76 patients (90 hips) with DDH aged ≥ 18 months, who underwent open reduction and a modified osteotomy by a single surgeon. Read More

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http://dx.doi.org/10.1155/2019/6021271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381572PMC
February 2019

Evaluation and Management of Septic Arthritis and its Mimics in the Emergency Department.

West J Emerg Med 2019 Mar 6;20(2):331-341. Epub 2018 Dec 6.

Rush University Medical Center, Department of Emergency Medicine, Chicago, Illinois.

Septic arthritis is a dangerous medical condition associated with significant morbidity and mortality. However, the differential diagnosis can be broad with conditions that mimic this disease and require different evaluation and treatment. This narrative review presents the emergency medicine evaluation and management, as well as important medical conditions that may mimic this disease. Read More

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http://dx.doi.org/10.5811/westjem.2018.10.40974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404712PMC

Treatment of osteonecrosis of the femoral head by core decompression and implantation of fully functional ex vivo-expanded bone marrow-derived mesenchymal stem cells: a proof-of-concept study.

Stem Cells Cloning 2019 1;12:11-16. Epub 2019 Mar 1.

Centro de Terapia Regenerativa Celular, Clínica Las Condes, Santiago, Chile,

Background: Based on several attributes involved in bone formation, bone marrow-resident mesenchymal stem cells (MSCs) have been employed in the treatment of patients suffering from femoral head osteonecrosis. Due to the low content of MSCs in the bone marrow, ex vivo expansion procedures are utilized to increase the cell number. Customarily, before administration of the resulting expanded cell product MSCs to the patient, its cellular identity is usually evaluated according to a set of "minimal phenotypic" markers, which are not modified by ex vivo processing. Read More

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http://dx.doi.org/10.2147/SCCAA.S181883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402444PMC

Salter osteotomy without open reduction in the Tönnis type II developmental hip dysplasia: A retrospective clinical study.

J Orthop Surg (Hong Kong) 2019 Jan-Apr;27(1):2309499019835572

1 Department of Orthopaedics and Traumatology, Faculty of Medicine, Firat University, Elazig, Turkey.

Purpose:: We aimed to evaluate the clinical and radiological outcomes of children older than 18 months who were treated with Salter osteotomy without open reduction for Tönnis type II hip dysplasia.

Methods:: Thirty-two type II hips of 24 patients were included in the study. The mean age was 43. Read More

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http://dx.doi.org/10.1177/2309499019835572DOI Listing

Naringin regulates bone metabolism in glucocorticoid-induced osteonecrosis of the femoral head via the Akt/Bad signal cascades.

Chem Biol Interact 2019 Mar 14;304:97-105. Epub 2019 Mar 14.

Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, 300052, People's Republic of China. Electronic address:

Purpose: Glucocorticoid-induced osteonecrosis of the femoral head (GIONFH) is a common disease following long-term use or large doses of glucocorticoids. The pathogenesis of GIONFH remains controversial, and abnormal bone metabolism caused by glucocorticoids(GCs) may be one of the important factors. Due to its positive effect on bone remodeling, naringin shows potential therapeutic effects in bone metabolism-related diseases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00092797183140
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http://dx.doi.org/10.1016/j.cbi.2019.03.008DOI Listing
March 2019
1 Read

Role of Bisphosphonates in Breast Cancer Therapy.

Curr Treat Options Oncol 2019 Mar 14;20(4):26. Epub 2019 Mar 14.

Division of Medical Oncology, University of Toronto and Princess Margaret Cancer Centre, 700 University Ave, 7-721, Toronto, ON, M5G 2M9, Canada.

Opinion statement Bisphosphonates are utilized routinely in breast cancer. In metastatic disease with bone involvement, bisphosphonates prevent or delay skeletal-related events and can improve pain control. Different agents have shown benefit compared with placebo or no treatment. Read More

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http://dx.doi.org/10.1007/s11864-019-0623-8DOI Listing
March 2019
2 Reads

Core Decompression for Post-Arthroscopic Osteonecrosis of the Lateral Tibial Plateau.

Knee Surg Relat Res 2019 Mar;31(1):76-80

Department of Trauma and Orthopaedic, Raigmore Hospital, NHS Highland, Inverness, UK.

Post-arthroscopic osteonecrosis is a rare complication that mostly occurs in the over 50s. It most commonly occurs in the medial femoral condyle, followed by the lateral femoral condyle then medial tibial plateau. We report the first case of lateral tibial plateau osteonecrosis in a young patient after arthroscopic lateral meniscectomy. Read More

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http://www.jksrr.org/journal/view.html?doi=10.5792/ksrr.18.0
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http://dx.doi.org/10.5792/ksrr.18.063DOI Listing
March 2019
2 Reads

Physiological concentrations of denosumab enhance osteogenic differentiation in human mesenchymal stem cells of the jaw bone.

Arch Oral Biol 2019 Mar 7;101:23-29. Epub 2019 Mar 7.

Department of Cranio-Maxillofacial Surgery, Hospital of the University of Regensburg, Franz-Josef-Strauß-Allee, 93053 Regensburg, Germany. Electronic address:

Objective: The aim of this study was to evaluate the possible influence of denosumab and zoledronate on proliferation and osteogenic differentiation of alveolar bone stem cells.

Design: Mesenchymal stem cells (MSCs) and dental follicle cells (DFCs) were grown under osteogenic differentiation with concentrations from 0.25 μM to 10 μM (zoledronate) and to 20 μM (denosumab). Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.03.005DOI Listing
March 2019
1 Read

Decrease of GSK3β Ser-9 Phosphorylation Induced Osteoblast Apoptosis in Rat Osteoarthritis Model.

Curr Med Sci 2019 Feb 13;39(1):75-80. Epub 2019 Mar 13.

Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, 430060, China.

Nowadays, the cumulative intake of glucocorticoids has become the most common pathogenic factor for non-traumatic osteonecrosis of the femoral head (ONFH). Apoptosis of osteoblasts is considered as the main reason of ONFH at the molecular level. Glycogen synthase kinase 3β (GSK3β) is an important regulator of cellular differentiation and apoptosis pathway, which can modulate the balance between osteoblasts and osteoclasts. Read More

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http://dx.doi.org/10.1007/s11596-019-2002-xDOI Listing
February 2019
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TRANSIENT OSTEOPOROSIS: CLINICAL SPECTRUM IN ADULTS AND ASSOCIATED RISK FACTORS.

Endocr Pract 2019 Mar 13. Epub 2019 Mar 13.

From: Division of Endocrinology, Diabetes, Metabolism and Nutrition, Department of Medicine; Mayo Clinic, Rochester, Minnesota, USA.

Objective: We aimed to describe the natural history of the rare clinical syndrome of transient osteoporosis (TO) and ascertain potential risk factors.

Design: Retrospective cohort study of adults with TO at Mayo Clinic, Rochester over 15 years.

Methods: Adults with acute onset joint pain worsened by weight bearing and bone marrow edema on MRI were included; exclusion criteria were trauma, tumors, rheumatic diseases, avascular necrosis, infection and hyperesthesia. Read More

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http://dx.doi.org/10.4158/EP-2018-0626DOI Listing
March 2019
3 Reads

Evolving Understanding of and Treatment Approaches to Slipped Capital Femoral Epiphysis.

Curr Rev Musculoskelet Med 2019 Mar 12. Epub 2019 Mar 12.

Boston Children's Hospital, Boston, MA, USA.

Purpose Of Review: To review slipped capital femoral epiphysis (SCFE), with a focus on new insights into its etiology and evolving methods of operative fixation.

Recent Findings: The epiphyseal tubercle and its size during adolescence are paramount to understanding the mechanism of SCFE. In chronic stable SCFE, the epiphysis rotates about the tubercle protecting the lateral epiphyseal vessels from disruption. Read More

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http://dx.doi.org/10.1007/s12178-019-09547-5DOI Listing
March 2019
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Evaluation of Quality of Life After Mandibular Reconstruction Using a Novel Fixed Implant-Supported Dental Prosthesis Concept: A Pilot Study.

Int J Prosthodont 2019 Mar/Apr;32(2):162-173

Purpose: To evaluate the feasibility and efficacy of a novel concept of early loaded (ie, within 2 weeks) implant-supported fixed dental prostheses (ISFDP) for patients who underwent mandibular reconstruction.

Materials And Methods: All patients requiring mandibular reconstruction between July 2013 and March 2016 at AZ Sint-Jan Brugge-Oostende AV were screened for dental rehabilitation according to the proposed concept. Of 17 patients, 10 were eligible for inclusion. Read More

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http://dx.doi.org/10.11607/ijp.6001DOI Listing
March 2019
1 Read

Diagnostic issue on spontaneous osteonecrosis of medial tibial plateau.

Authors:
Jun Jiang Jian Chen

Chin Med J (Engl) 2019 Mar;132(6):755-756

Arthritis Clinic and Research Center, Peking University People Hospital, Beijing 100044, China.

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http://dx.doi.org/10.1097/CM9.0000000000000119DOI Listing
March 2019
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Efficacy and safety of denosumab compared to bisphosphonates in improving bone strength in postmenopausal osteoporosis: a systematic review.

Singapore Med J 2019 Mar 11. Epub 2019 Mar 11.

Department of Infectious Diseases, Singapore General Hospital, Singapore.

Introduction: Osteoporosis is the main cause of fractures among women after menopause. This study aimed to evaluate the efficacy and safety of denosumab compared to bisphosphonates in treating postmenopausal osteoporosis.

Methods: Databases including PubMed and the Cochrane Central Register of Controlled Trials were systematically searched for randomised controlled trials (RCTs) that directly compared denosumab and bisphosphonates. Read More

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http://dx.doi.org/10.11622/smedj.2019028DOI Listing
March 2019
1 Read

Non-concentric Reduction Due to Entrapped Loose Bone Piece During a Single-stage Bilateral Total Hip Arthroplasty.

Cureus 2018 Dec 27;10(12):e3780. Epub 2018 Dec 27.

Orthopaedics, All India Institute of Medical Sciences, Bhubaneswar, IND.

Total hip arthroplasty (THA) is the treatment of choice for Grade IV avascular necrosis of the femoral head. Dislocation following THA, although rare, is a known complication. Common causes of unsuccessful reduction include interposition of soft tissue, component loosening, malalignment, and inadequate muscle relaxation following anaesthesia. Read More

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http://dx.doi.org/10.7759/cureus.3780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395014PMC
December 2018
1 Read

Discovery and validation an eight-biomarker serum gene signature for the diagnosis of steroid-induced osteonecrosis of the femoral head.

Bone 2019 Mar 8;122:199-208. Epub 2019 Mar 8.

Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China. Electronic address:

Steroid-induced osteonecrosis of the femoral head (SONFH) is difficult to be diagnosed at the early stages when it can be administrated effectively. Yet, to date no study has been performed to identify diagnostic biomarkers and to develop diagnostic models for SONFH. In the current study, a total of 60 SONFH patients with Association Research Circulation Osseous (ARCO) stages I-IV, and 20 controls were enrolled and divided into the discovery and validation cohorts. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.008DOI Listing
March 2019
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Effects of anterior boundary of the necrotic lesion on the progressive collapse after varus osteotomy for osteonecrosis of the femoral head.

J Orthop Sci 2019 Mar 7. Epub 2019 Mar 7.

Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Background: Anterior localization of the necrotic lesion was recently proposed as an important factor for the occurrence of collapse even in medially located osteonecrosis of the femoral head (ONFH). We examined the effects of the anterior boundary of the necrotic lesion on progressive collapse after varus osteotomy for ONFH.

Methods: We reviewed the outcomes of 31 hips in 27 patients with ONFH treated by transtrochanteric curved varus osteotomy (CVO) from 2000 to 2012 with a mean follow-up of 10. Read More

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http://dx.doi.org/10.1016/j.jos.2019.02.014DOI Listing
March 2019
1 Read

Genetic polymorphisms in IL1B predict susceptibility to steroid-induced osteonecrosis of the femoral head in Chinese Han population.

Osteoporos Int 2019 Mar 9. Epub 2019 Mar 9.

Department of Osteonecrosis and Joint Reconstruction Ward, HongHui Affiliated Hospital of Xi'an Jiaotong University College of Medicine, #555 Youyi East Road, Xi'an, 710054, Shaanxi, China.

The purpose of this research was to examine if the IL1B gene polymorphism has impact on the risk of steroid-induced ONFH in Chinese population. We found that IL1B rs1143630 decreased the SANFH's risk and IL1B rs2853550 increased the risk of steroid-induced ONFH. So, we guess that IL1B gene influences the genetic susceptibility of steroid-induced ONFH. Read More

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http://link.springer.com/10.1007/s00198-019-04835-9
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http://dx.doi.org/10.1007/s00198-019-04835-9DOI Listing
March 2019
4 Reads

Inhibition of macrophage viability by bound and free bisphosphonates.

Acta Histochem 2019 Mar 6. Epub 2019 Mar 6.

Faculty of Dentistry, Thammasat University, Rangsit campus, 99 Moo 18 Pahonyothin Rd., Klong Luang, Pathumthani, 12120, Thailand.

Introduction: Long-term administration of bisphosphonates (BPs) may cause osteonecrosis of the jaw (BRONJ). After administration, 50% of BPs in the circulation rapidly binds to calcium phosphate of bone. Two forms, bound and free BPs, may affect cells residing in bone including macrophages. Read More

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http://dx.doi.org/10.1016/j.acthis.2019.02.007DOI Listing
March 2019
2 Reads

Osteonecrosis in pediatric cancer survivors: Epidemiology, risk factors, and treatment.

Surg Oncol 2019 Mar 4;28:214-221. Epub 2019 Feb 4.

Division of Orthopaedic Oncology, Department of Orthopaedic Surgery, The Johns Hopkins University, Baltimore, MD, USA. Electronic address:

Several treatment regimens for childhood malignancies have been associated with the development of osteonecrosis, including radiation therapy, glucocorticoid medications, immunotherapy (including anti-angiogenic agents), and several chemotherapeutic agents. Adolescents older than 10 years are at greatest risk of developing osteonecrosis within 1 year of initiating therapy. Screening with magnetic resonance imaging in this high-risk population may be a useful method for detecting osteonecrosis. Read More

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http://dx.doi.org/10.1016/j.suronc.2019.02.001DOI Listing

Osteonecrosis of the Femoral Head.

Orthop Clin North Am 2019 Apr 12;50(2):139-149. Epub 2019 Feb 12.

Department of Orthopedic Surgery, University of Virginia, University of Virginia School of Medicine, 400 Ray C. Hunt Drive, #300, Charlottesville, VA 22903, USA. Electronic address:

Osteonecrosis of the femoral head most commonly arises from trauma or corticosteroid and alcohol use but is also associated with blood dyscrasias and metabolic and coagulation disorders. Initial evaluation includes a history and physical examination and plain radiographs. Early-stage osteonecrosis is best evaluated by MRI. Read More

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http://dx.doi.org/10.1016/j.ocl.2018.10.001DOI Listing
April 2019
1 Read

Osteonecrosis of the jaw in the era of targeted therapy and immunotherapy in oncology.

J Korean Assoc Oral Maxillofac Surg 2019 Feb 26;45(1):3-8. Epub 2019 Feb 26.

Hemato-Oncology Clinic, Department of Internal Medicine, Brugmann University Hospital Center, Brussels, Belgium.

Osteonecrosis of the jaw (ONJ) is a well-known pathological condition in oncology derived from the use of bisphosphonates (BPs) and denosumab. Many molecular and immunological targets have been introduced for daily use in cancer treatment in recent years; consequently, new cases of ONJ have been reported in association with these drugs, especially if administered with BPs and denosumab. When the drugs are administered alone, ONJ is rarely seen. Read More

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http://dx.doi.org/10.5125/jkaoms.2019.45.1.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400698PMC
February 2019
1 Read

Challenges of denosumab in giant cell tumor of bone, and other giant cell-rich tumors of bone.

Curr Opin Oncol 2019 Mar 5. Epub 2019 Mar 5.

Department of Medical Oncology.

Purpose Of Review: Giant cell tumor of bone (GCTB) is an uncommon benign primary bone tumor, consisting of receptor activator of nuclear factor kappa-B (RANK) expressing reactive osteoclast-like giant cells and neoplastic spindle-shaped cells. Denosumab was approved by FDA in 2013 and by EMA in 2014 to treat adults and skeletally mature adolescents with unresectable GCTB or when resection is likely to result in severe morbidity. However, there is much discussion regarding the optimal applied treatment strategy. Read More

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http://dx.doi.org/10.1097/CCO.0000000000000529DOI Listing
March 2019
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[Mid-Term Results of Treatment of Severe Grades of Slipped Capital Femoral Epiphysis without Surgical Hip Dislocation].

Acta Chir Orthop Traumatol Cech 2019 ;86(1):23-32

Ortopedická klinika 1. lékařské fakulty Univerzity Karlovy, Institutu postgraduálního vzdělávání ve zdravotnictví a Nemocnice Na Bulovce, Praha.

PURPOSE OF THE STUDY To evaluate the results of treatment of acute and chronic severe slips of slipped capital femoral epiphysis. The tested hypothesis was that the results will be comparable with the methods using surgical hip dislocation. MATERIAL AND METHODS In the period 1996-2014, 26 patients were treated for severe slips ( >60°). Read More

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January 2019
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Osteonecrosis in Children and Adolescents With Acute Lymphoblastic Leukemia: Early Diagnosis and New Treatment Strategies.

Anticancer Res 2019 Mar;39(3):1259-1266

Department of Women's and Children's Health, Pediatric Haemato-Oncology, University of Padua, Padua, Italy.

Background/aim: In the last few decades, treatment strategies for acute lymphoblastic leukemia (ALL) have been associated not only with improvement of prognosis, but also with an increasing rate of late complication as osteonecrosis (ON). Herein, the cumulative incidence, risk factors, new conservative therapeutic strategies as hyperbaric oxygen therapy (HBO), and outcome of symptomatic ON were studied in pediatric patients with ALL.

Patients And Methods: Between 2000 and 2017, 495 children and young adolescents with a diagnosis of ALL were evaluated. Read More

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http://dx.doi.org/10.21873/anticanres.13236DOI Listing
March 2019
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Plasma C-terminal cross-linking telopeptide of type II collagen as a biomarker in advanced stages of femoral head osteonecrosis.

Biomed Pharmacother 2019 Mar 15;111:1213-1220. Epub 2019 Jan 15.

Hip preserving ward, No. 3 Orthopaedic region, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, PR China; Institute of hip joint, Guangzhou University of Chinese Medicine, Guangzhou, PR China. Electronic address:

Aim: The aim of this study is to investigate the potential role of C-terminal cross-linking telopeptide of type II collagen (CTX-II) in the development of femoral head osteonecrosis (FHN).Materials and methodsOne hundred and thirty-two patients diagnosed with FHN and 66 age- and sex-matched healthy subjects were included in this cross-sectional case-control study between May 2016 and November 2016. Bone histomorphology, cartilaginous immunohistochemistry, Western blotting, and level of plasma CTX-II, as well as the receiver operating characteristic (ROC) curve, were evaluated. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.01.013DOI Listing
March 2019
1 Read

Comment on: Medication-related osteonecrosis of the jaw in osteoporotic patients: prevention and management.

Singapore Med J 2019 01;60(1):52

Department of Restorative Dentistry, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia.

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http://dx.doi.org/10.11622/smedj.2019006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351692PMC
January 2019
2 Reads

Dhs plus anti-rotational screw vs cannulated screws for femoral neck fractures: an analysis of clinical outcome and incidence regarding avn.

Acta Orthop Belg 2018 Sep;84(3):279-283

The aim of this study was to compare the union time, functional outcome and complications in patients with femoral neck fractures treated with percutaneous cannulated screws or dynamic hip screw (DHS) plus antirotational screw. We selected 117 consecutive patients having a hip fracture at any level within the Garden classification, treated at the Orthopedics and Traumatology Clinic in Perugia from 2010 to 2011. Average patient age was 67. Read More

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September 2018
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Intermediate to Long-term Results of Femoral Neck Lengthening (Morscher Osteotomy).

J Pediatr Orthop 2019 Apr;39(4):181-186

Pediatric Orthopedics Unit, Ha-Emek Hospital, Afula, Israel.

Background: Femoral neck lengthening and transfer of the greater trochanter were introduced by Morscher as treatment for patients with coxa breva and overgrowth of the greater trochanter. In this study we evaluated intermediate and long-term results of this operation.

Methods: We reviewed clinical and radiographic results of 18 patients (20 hips) who were treated by Morscher osteotomy. Read More

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http://dx.doi.org/10.1097/BPO.0000000000000906DOI Listing
April 2019
5 Reads

Spontaneous healing of avascular necrosis of the femoral head in sickle cell disease.

Am J Hematol 2019 Mar 5. Epub 2019 Mar 5.

Division of Hematology/Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.

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http://dx.doi.org/10.1002/ajh.25453DOI Listing
March 2019
2 Reads

Spontaneous Osteonecrosis of the Tarsal Navicular: A Report of Two Cases.

Case Rep Orthop 2019 30;2019:5952435. Epub 2019 Jan 30.

Department of Orthopaedic Surgery, Graduate School of Medicine, Mie University, 2-174 Edobashi, Tsu, Mie 514-8507, Japan.

Spontaneous osteonecrosis of the tarsal navicular, called the Mueller-Weiss syndrome, is an uncommon disease. Patients who are resistant to conservative treatment require operative treatment. However, there is no established operative treatment. Read More

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http://dx.doi.org/10.1155/2019/5952435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374815PMC
January 2019
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Perceptions and attitudes of patients towards medication-related osteonecrosis of the jaw (MRONJ): a qualitative study in England.

BMJ Open 2019 Mar 3;9(3):e024376. Epub 2019 Mar 3.

School of Medicine, University of Sunderland, Sunderland, UK.

Objective: To explore the impact of medication-related osteonecrosis of the jaw (MRONJ) on quality of life and to explore the attitudes and perceptions of patients towards the multidisciplinary approach to the prevention of the condition.

Design: Interpretivist methodology using qualitative semistructured interviews.

Setting: Primary care general medical practices and secondary care dental services in England. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024376DOI Listing
March 2019
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Osteoclastic expression of higher-level regulators NFATc1 and BCL6 in medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy: a comparison with osteoradionecrosis and osteomyelitis.

J Transl Med 2019 Mar 4;17(1):69. Epub 2019 Mar 4.

Department of Oral and Maxillofacial Surgery, Friedrich-Alexander University Erlangen-Nürnberg, Glückstraße 11, 91054, Erlangen, Germany.

Background: With an increasing indication spectrum of antiresorptive drugs, the medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy [MRONJ (BP)] is continuously gaining clinical relevance. Impaired osteoclast function, accompanied by altered cell morphology and expression of osteoclastic effector proteins, contributes to the pathogenesis of MRONJ (BP). However, the underlying regulatory mechanisms at a transcriptional level are unaddressed so far. Read More

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http://dx.doi.org/10.1186/s12967-019-1819-1DOI Listing

Global urinary metabolic profiling of the osteonecrosis of the femoral head based on UPLC-QTOF/MS.

Metabolomics 2019 Feb 20;15(3):26. Epub 2019 Feb 20.

Department of Orthopedics, Fuling Center Hospital of Chongqing City, Chongqing, 408000, China.

Introduction: Osteonecrosis of the femoral head (ONFH), one of the widespread orthopedic diseases with a decrease in bloodstream to the femoral head, is frequently accompanied by cellular death, trabecula fracture, and collapse of the articular surface. The exactly pathological mechanism of ONFH remains to explore and further identify.

Objectives: The aim was to identify the global urinary metabolic profiling of ONFH and to detect biomarkers of ONFH. Read More

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http://dx.doi.org/10.1007/s11306-019-1491-8DOI Listing
February 2019
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3.855 Impact Factor

Clinical significance of periosteal reaction as a predictive factor for treatment outcome of medication-related osteonecrosis of the jaw.

J Bone Miner Metab 2019 Mar 4. Epub 2019 Mar 4.

Department of Otolaryngology Head and Neck Surgery, Kansai Medical University, 2-3-1 Shinmachi, Hirakata, Osaka, 573-1191, Japan.

Regarding treatment strategies for medication-related osteonecrosis of the jaw (MRONJ), surgical therapy has recently been reported to be more effective than conservative therapy. However, some patients did not achieve complete healing, even when extensive surgery was performed. Periosteal reaction in MRONJ patients is often observed by the CT examination. Read More

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http://dx.doi.org/10.1007/s00774-019-00994-1DOI Listing
March 2019
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Resection arthroplasty in radiation-induced osteonecrosis of the hip.

J Clin Orthop Trauma 2019 Mar-Apr;10(2):364-367. Epub 2018 Feb 24.

Department of Orthopedic Surgery, Kosin University Gospel Hospital, Busan, Republic of Korea.

Purpose: The purpose of this study was to evaluate the choice of appropriate surgical procedure through follow-up of postoperative results in patients with radiation-induced osteonecrosis of the hip.

Materials And Methods: From January 1990 to December 2010, 25 patients underwent surgery for hip osteonecrosis after pelvic irradiation, for a total of 31 cases. The mean patient age was 61. Read More

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http://dx.doi.org/10.1016/j.jcot.2018.02.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383166PMC
February 2018
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Glucocorticoid induces osteonecrosis of the femoral head in rats through GSK3β-mediated osteoblast apoptosis.

Biochem Biophys Res Commun 2019 Feb 28. Epub 2019 Feb 28.

Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, Hubei, China. Electronic address:

Objective: One of the important causes of glucocorticoids (GCs)-induced osteonecrosis of the femoral head (ONFH) is osteoblast apoptosis. Glycogen synthase kinase 3β (GSK3β) has been reported to be related to dexamethasone (Dex)-induced osteoblast apoptosis. This study aimed to determine whether GSK3β plays role in GC-induced ONFH and investigate the underlying mechanism. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.02.118DOI Listing
February 2019

c-ANCA vasculitis after initiation of denosumab.

BMJ Case Rep 2019 Mar 1;12(3). Epub 2019 Mar 1.

University of Miami Miller School of Medicine at Holy Cross Hospital, Fort Lauderdale, Florida, USA.

Denosumab is a fully human antibody to receptor activator of nuclear factor kappa-B ligand (RANKL), and it is administered every 6 months in women with postmenopausal osteoporosis (PMO) at high risk for fracture. Adverse effects of denosumab include musculoskeletal pain, hypercholesterolaemia, symptomatic hypocalcaemia, osteonecrosis of the jaw and cutaneous events such as angioedema, cellulitis and pustular dermatitis. While the possibility of vasculitis was mentioned in the product Monograph as well as in the WHO Newsletter, this is the first case, to our knowledge, of cytoplasmic-ANCA (c-ANCA) associated vasculitis officially published in the literature. Read More

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http://dx.doi.org/10.1136/bcr-2018-228336DOI Listing

Influence of Bisphosphonates on Clinical Features of Osteoradionecrosis of the Maxilla and Mandible.

Oral Dis 2019 Mar 1. Epub 2019 Mar 1.

Stomatology Department, School of Dentistry, São Paulo University, São Paulo, Brazil.

Background And Purpose: Osteoradionecrosis is one of the most severe adverse effects of radiotherapy to the head and neck region. Medication-induced osteonecrosis of the jaw has been reported among patients using bisphosphonates. However, the impact of radiotherapy on osteonecrosis in patients using bisphosphonates has not yet been described. Read More

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http://dx.doi.org/10.1111/odi.13081DOI Listing
March 2019
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Inferior calcar buttress reduction pattern for displaced femoral neck fractures in young adults: a preliminary report and an effective alternative.

J Orthop Surg Res 2019 Feb 28;14(1):70. Epub 2019 Feb 28.

The Department of Orthopaedic Surgery, Yangpu Hospital, Tongji University School of Medicine, 450Tengyue Road, Shanghai, 200090, People's Republic of China.

Background: Fracture reduction quality is of paramount importance for osteosynthesis. The aim of this study was to report the outcome of an inferior cortical buttress non-anatomic reduction pattern and internal fixation for displaced femoral neck fractures (Garden types III and IV) in young adults.

Methods: A retrospective analysis of 46 displaced femoral neck fractures was performed, which were treated by closed reduction and internal fixation with parallel cannulated screws. Read More

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http://dx.doi.org/10.1186/s13018-019-1109-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396447PMC
February 2019
2 Reads