Search Our Scientific Publications & Authors

Biomed Res Int 2020 6;2020:4176926. Epub 2020 May 6.

The First Department of Orthopedics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, China.

Small extracellular vesicles (sEVs) derived from bone marrow mesenchymal stem cells (BMMSCs) from individuals with steroid-induced osteonecrosis of the femoral head (ONFH) have not been studied. The objective of the present study was to compare the proosteogenic and proangiogenic effects of sEVs derived from BMMSCs from rats with steroid-induced ONFH (oBMMSCs-sEVs) and sEVs derived from BMMSCs from normal rats (nBMMSCs-sEVs). BMMSCs were isolated from steroid-induced ONFH rats and healthy rats. Read More

Arthroscopy 2020 May 24. Epub 2020 May 24.

Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-chuo, Kobe, 650-0017, Japan.

Purpose: To evaluate the association of labral length with acetabular morphology and clinical symptoms.

Methods: Patients treated at our hip joint clinic between January 2015 and December 2018 were retrospectively enrolled into the study. Our sample included patients diagnosed with one or more of the following: hip labral tear, femoroacetabular impingement (FAI), and developmental dysplasia of the hip (DDH). Read More

J Int Med Res 2020 May;48(5):300060520925999

Department of Osteonecrosis and Hip Surgery, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China.

Objective: This study was performed to compare the clinical outcomes and performance of the collum femoris-preserving (CFP) stem (Waldemar Link GmbH & Co., Hamburg, Germany) and the Tri-Lock stem (DePuy Orthopaedics, Warsaw, IN, USA) in terms of femoral offset (FO) and leg length reconstruction.

Methods: Clinical and radiographic data of patients who underwent total hip arthroplasty with either a CFP stem or Tri-Lock stem from January 2016 to March 2017 were compared (65 and 57 patients, respectively). Read More

J Arthroplasty 2020 May 5. Epub 2020 May 5.

Department of Orthopaedic Surgery, Stanford University Medical Center Outpatient Center, Redwood City, CA.

Background: Joint preservation is more effective in early-stage osteonecrosis of the femoral head (ONFH); thus, prompt diagnosis when the femoral head is still salvageable is important. We report a 20-year retrospective study that summarizes age at presentation, etiology, and Association Research Circulation Osseous stage at diagnosis.

Methods: Our database was reviewed to identify patients younger than 65 years of age who were diagnosed with atraumatic ONFH between 1998 and 2018. Read More

BMC Musculoskelet Disord 2020 May 26;21(1):327. Epub 2020 May 26.

Department of Orthopedic Surgery and Traumatology, University Hospital of Basel, Basel, Switzerland.

Background: The most frequently used surgical procedures for treating a proximal humeral fracture (PHF) are plate osteosynthesis, nail osteosynthesis and arthroplasty. Evidence-based recommendations for an appropriate surgical procedure after PHF requires transparent and valid safety data. We performed a systematic review to examine reported terms and definitions of complications after surgically-treated PHFs. Read More

J Clin Rheumatol 2020 Jun;26(4):e77

From the Department of Orthopaedics & Rheumatology, Aster Medcity, Kochi, Kerala, India.

J Pediatr Orthop B 2020 May 22. Epub 2020 May 22.

Department of Medicine, Ataturk Universitesi.

Closed reduction is an effective treatment method for developmental dysplasia of the hip (DDH). Still, there are certain controversial issues regarding the timing of the treatment. In this study, we investigated the results of closed reduction and Outcomes of 302 hips of 218 patients treated with closed reduction have been analyzed retrospectively. Read More

Arch Orthop Trauma Surg 2020 May 25. Epub 2020 May 25.

Orthopaedic Surgery Department, Universite Paris Diderot UFR de Medecine, Paris, France.

Purpose: Although shoulder arthroplasty is relatively safe in general population, it remains unclear in transplant recipient. Aim of this study was to determine outcomes and morbidity after shoulder arthroplasty in lung transplant recipients.

Methods: A retrospective analysis was performed at our university hospital center from 2001 to 2015. Read More

J Orthop Surg Res 2020 May 24;15(1):183. Epub 2020 May 24.

Department of Orthopedic Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou City, 221002, Jiangsu Province, China.

Background: The aim of the present study was to investigate clinical and radiological outcomes of autologous tricortical iliac grafting performed through a window created at the femoral head without suturing the opened articular cartilage for the treatment of osteonecrosis of the femoral head (ONFH), called modified trapdoor procedures.

Materials And Methods: A total of 59 consecutive patients (67 hips; 36 males and 23 females) with ONFH were included in this study, which was conducted from April 2009 to March 2012. Patients' age ranged from 27 to 46 years old, with a mean age of 36. Read More

Korean J Fam Med 2020 May 25. Epub 2020 May 25.

Department of Orthopaedics, Faculty of Medicine, University Teknologi MARA, Sungai Buloh Campus, Sungai Buloh, Malaysia.

Avascular necrosis, or osteonecrosis of the femoral head, is a debilitating condition which leads to the destruction of the hip joint due to an interruption in the blood supply to the bony region and is most commonly due to trauma. The case discussed here has been highlighted as it presented as non-traumatic osteonecrosis of the femoral head with an absence of risk factors in a healthy adult male. A 37-year-old male presented with a 4-month history of recurrent left hip pain, which worsened with initiation of movement and weightbearing on the affected side. Read More

Acta Biomater 2020 May 21. Epub 2020 May 21.

Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Department of Sports Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Hunan Key Laboratory of Organ Injury, Aging and Regenerative Medicine, Changsha, Hunan 410008, China; Hunan Key Laboratory of Bone Joint Degeneration and Injury, Changsha, Hunan 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Key Laboratory of Biological Nanotechnology of National Health Commission, Changsha, Hunan 410008, China. Electronic address:

Osteonecrosis of the femoral head (ONFH) frequently occurs after glucocorticoid (GC) treatment. Extracellular vesicles (EVs) are important nano-sized paracrine mediators of intercellular crosstalk. This study aimed to determine whether EVs from human urine-derived stem cells (USC-EVs) could protect against GC-induced ONFH and focused on the impacts of USC-EVs on angiogenesis and apoptosis to explore the mechanism by which USC-EVs attenuated GC-induced ONFH. Read More

Int J Surg Case Rep 2020 May 8;71:85-90. Epub 2020 May 8.

Department of Orthopaedic & Traumatology, Cipto Mangunkusumo National Central Hospital and Faculty of Medicine, Universitas Indonesia, Jalan Diponegoro No. 71, Central Jakarta, Jakarta 10430, Indonesia.

Introduction: Traumatic dislocation of the hip is a very severe injury. Posterior hip dislocation can be associated with acetabular fracture, which can ultimately result in a higher incidence of complications.

Case Presentation: We present a case report of 26-year-old men with a motor vehicle accident and suffered a posterior hip dislocation on left hip joint and acetabular fracture with Judet-Letournel type posterior wall and femoral head fracture. Read More

BMC Musculoskelet Disord 2020 May 23;21(1):323. Epub 2020 May 23.

Osteonecrosis and Joint Reconstruction Ward, Department of Joint Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, 710054, P.R. China.

Background: Consensus on tibial rotation in total knee arthroplasty (TKA) remains controversial. The present study aimed to investigate the closest anatomical reference to surgical epicondylar axis (SEA) among 10 tibial markers in Chinese adults.

Methods: This study included examination of 122 normal lower extremities. Read More

Photodiagnosis Photodyn Ther 2020 May 20:101826. Epub 2020 May 20.

School of Dentistry, University of Santo Amaro, São Paulo, Brazil. Electronic address:

Bone 2020 May 20:115443. Epub 2020 May 20.

Department of Oncology and Metabolism, University of Sheffield, United Kingdom. Electronic address:

The anti-resorptive properties of bisphosphonates have been explored to manage several conditions that traditionally have required a surgical solution. In osteonecrosis, their use is predicated on the principle that bone collapse occurs during the revascularisation phase of the disease. If the associated resorptive activity were modulated, the resultant preserved joint architecture may improve clinical outcome and reduce the need for joint replacement. Read More

Int Orthop 2020 May 22. Epub 2020 May 22.

Department of Orthopaedic Surgery, National University Health System, National University Hospital, 1E Kent Ridge Road, NUHS Tower Block Level 11, Singapore, 119074, Singapore.

Purpose: The review aims to provide a summary of the current literature regarding common medications prescribed in orthopaedic surgery and their potential implications in COVID-19 patients.

Methods: A systematic review was performed using the PRISMA guidelines. All clinical studies, reviews, consensus and guidelines related to the above medications and COVID-19 were included. Read More

Clin Oral Investig 2020 May 22. Epub 2020 May 22.

Department of Oral and Maxillofacial Surgery, Ludwig-Maximilians University of Munich, Lindwurmstr. 2a, D-80336, Munich, Germany.

Objectives: Fluorescence-guided bone surgery is a well-established technique in the treatment of medication-related osteonecrosis of the jaw. No histopathological evidence for bone auto-fluorescence is currently available, and thus, any differences from tetracycline-fluorescence remain unclear. Therefore, the goals of this study were to find out if macroscopic and histological differences occur between the auto- and tetracycline-fluorescence in the delineation of viable and necrotic jawbone in the mini-pig. Read More

Medicine (Baltimore) 2020 May;99(20):e20259

First Ward of Orthopedis Department, First Affiliated Hospital of Jiamusi University.

Background: Femoral head avascular necrosis (FHAN) is a very common condition among elderly population. Previous studies have reported that total hip arthroplasty (THAP) can benefit patients with such condition. However, no study systematically addressed this topic. Read More

Medicine (Baltimore) 2020 May;99(20):e20215

Department of Orthopaedics, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.

Hip preserving procedures are still a challenge in late-stage osteonecrosis of femoral head (ONFH) patients. We aimed to compare the clinical outcomes of surgical dislocation and impaction bone graft and surgical dislocation and rotational osteotomy for treatment of ONFH in Association Research Circulation Osseous (ARCO) stage III patients.We retrospectively reviewed 30 ARCO stage III patients (33 hips) who had surgical dislocation and impaction bone graft or surgical dislocation and rotational osteotomy in our center from June 2012 to December 2017. Read More

Acta Orthop Traumatol Turc 2020 May 22. Epub 2020 May 22.

Department of Orthopaedic Surgery, Chung-Shan Medical University Hospital, Taichung City, Taiwan;Institute of Medicine, Chung-Shan Medical University, Taichung City, Taiwan.

Acute lunate and perilunate dislocations are not commonly observed injuries. In particular, palmar-divergent dislocation is a very rare injury with only a few cases reported in the literature. In this report, we describe the case of a 37-year-old patient with palmar-divergent dislocation of the scaphoid and lunate and discuss the mechanism of this type of injury. Read More

Acta Orthop Traumatol Turc 2020 May 22. Epub 2020 May 22.

Department of Orthopaedics, Hanil General Hospital, Seoul, Korea.

Objective: Internal fixation with cannulated screws for nondisplaced femoral neck fractures in the elderly has substantial reoperation and mortality rates. The selection of either internal fixation or arthroplasty for nondisplaced femoral neck fracture is debatable.

Methods: We performed a systematic review of the literature regarding complications in the internal fixation of nondisplaced femoral neck fractures in elderly (>60 years old) patients. Read More

Oral Maxillofac Surg 2020 May 21. Epub 2020 May 21.

Department of Conservative Dentistry and Periodontology, University Hospital, LMU, Goethestraße 70, 80336, Munich, Germany.

Bemcentinib is a newly developed AXL inhibitor that is currently under investigation in phase II trails for the treatment of acute myeloblastic leukemia (AML). Clinical and radiographic findings in this case were very similar to cases of MRONJ in patients receiving Sunitinib or other anti-angiogenetic substances, assuming that Bemcentinib may cause similar oral side effects. We present a male 81-year-old patient with a manifestation of alveolar bone necrosis at the central upper incisors following a 2-month regimen with the AXL-inhibitor Bemcentinib, administered for the treatment of secondary acute myeloblastic leukemia (sAML). Read More

J Orthop Translat 2020 May 14;22:109-115. Epub 2019 Nov 14.

Institute of Orthopedics, Beijing Key Laboratory of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, Chinese PLA General Hospital, Beijing, 100853, China.

Purpose: The aim of this study was to investigate the location characteristics of cystic lesions in a three-dimensional context and discuss the mechanism of formation.

Methods: A total of 155 femoral head computed tomography images from 94 patients diagnosed with stage II and III osteonecrosis of the femoral head were retrospectively reviewed. Three-dimensional structures of the femoral head including the cystic lesions and necrotic area were reconstructed. Read More

Nutrients 2020 May 19;12(5). Epub 2020 May 19.

Health Psychology Multidisciplinary Research Center, CRU, CiiEM, Egas Moniz-Cooperativa de Ensino Superior, 2829-511 Caparica, Almada, Portugal.

Vitamin D (VD) levels have been gaining growing attention in Oral Health. During growth and adulthood, VD deficiency (VDD) is associated with a wide variety of oral health disorders, and impaired VD synthesis may expedite some of these conditions. In children, severe VDD can induce defective tooth mineralization, resulting in dentin and enamel defects. Read More

Bone 2020 May 11;137:115411. Epub 2020 May 11.

Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology & Musculoskeletal Sciences, University of Oxford, Oxford, UK; Mellanby Centre for Bone Research, University of Sheffield, Sheffield, UK.

Alendronate was synthesized in 1970s in a search for inhibitors of calcification. Istituto Gentili investigators identified it as a potent inhibitor of bone resorption and obtained a patent covering its use in the treatment of osteoporosis and other disorders of excessive bone resorption in the 1980s. Merck licensed alendronate in 1988 and its pharmaceutical chemists reformulated it as a sodium salt with good solubility in a tablet that reduced its potential for esophageal irritation. Read More

J Endod 2020 May 8. Epub 2020 May 8.

Department of Endodontics, Division of Oral Functional Science and Rehabilitation, Asahi University School of Dentistry, 1851, Hozumi, Mizuho-city, Gifu 501-0296, Japan.

Although bisphosphonates (BPs) are widely used to treat conditions such as osteoporosis, they may cause osteonecrosis of the jaw. We treated a patient with no history of tooth extraction or other surgical treatment who developed medication-related osteonecrosis of the jaw (MRONJ) with secondary pulpal disease. A 79-year-old woman presented with purulence discharge from the gum at the incisor region. Read More

Cell Biol Int 2020 May 21. Epub 2020 May 21.

Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan Province, P. R China.

Previous studies have shown that the tumor necrosis factor-α (TNF-α) levels in serum and bone tissues form avascular necrosis of femoral head (ANFH) patients were higher than that of normal individuals, indicating TNF-α might play a role in the pathogenesis of ANFH. However, the underlying mechanisms remain unclear. Hematoxylin and Eosin (HE) staining was performed to show the pathological changes of ANFH bone tissues. Read More

J Cell Physiol 2020 May 21. Epub 2020 May 21.

Department of Spine Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.

Glucocorticoid-induced osteonecrosis of the femoral head (GIOFH) is one of the most common complications of glucocorticoid administration. By chelating Fe , desferoxamine (DFO) was reported to be able to activate the HIF-1α/VEGF pathway and promote angiogenesis. In the present study, we examined whether DFO administration could promote angiogenesis and bone repair in GIOFH. Read More

Oral Dis 2020 May 21. Epub 2020 May 21.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases &, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, P.R. China.

Objectives: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a severe complication of systemic nitrogen-containing bisphosphonates (N-BPs) administration, which lead to osteonecrosis, pain and infection. Despite much effort, effective remedies are yet to be established. This study aimed to investigate potential recovery effect of borate bioactive glass (BBG) in vitro and in vivo. Read More

Sci Transl Med 2020 May;12(544)

Division of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, BJC Institute of Health, 425 S. Euclid Ave., St. Louis, MO 63110, USA.

Nitrogen-containing bisphosphonates (N-BPs), such as alendronate, are the most widely prescribed medications for diseases involving bone, with nearly 200 million prescriptions written annually. Recently, widespread use of N-BPs has been challenged due to the risk of rare but traumatic side effects such as atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ). N-BPs bind to and inhibit farnesyl diphosphate synthase, resulting in defects in protein prenylation. Read More

J Orthop Surg Res 2020 May 20;15(1):180. Epub 2020 May 20.

Department of Pediatric Orthopedics, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang, China.

Purpose: The anterior and medial approaches in open reduction for developmental dysplasia of the hip (DDH) had been widely used. The former could not directly approach the intra-articular interposition, while the latter had been associated with injury to blood vessel and avascular necrosis (AVN) of the femoral head. Meanwhile, the bikini incision had also been mentioned in some studies. Read More

Med Sci Monit 2020 May 20;26:e922624. Epub 2020 May 20.

Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China (mainland).

BACKGROUND Vascularized fibular grafting (VFG) has been successfully employed for treating avascular necrosis of the femoral head (ANFH). In this study, we aimed to evaluate the bone viability of the femoral head and subchondral bone following VFG by using single photon emission computerized tomography and computerized tomography (SPECT/CT). MATERIAL AND METHODS Between March 2011 and June 2014, 14 ANFH patients (17 hips) treated with VFG at Zhongshan Hospital, Fudan University, were prospectively enrolled. Read More

Medicina (Kaunas) 2020 May 16;56(5). Epub 2020 May 16.

Department of Anatomy, School of Medicine, Keimyung University, Daegu 42601, Korea.

: Alterations in mitochondrial DNA (mtDNA) have been observed and studied in various diseases. However, the clinical value of the mtDNA copy number (mtDNA-CN) alterations in osteonecrosis of the femoral head (ONFH) is poorly understood. In the present study, we investigated whether alterations in mtDNA-CNs are associated with clinicopathological parameters in ONFH. Read More

J Orthop Trauma 2020 May 8. Epub 2020 May 8.

Naval Medical Center San Diego.

Objectives: To review the clinical course, complication rates, and mid-term functional outcomes associated with the treatment of displaced femoral neck stress fractures (FNSFs) DESIGN:: Retrospective Case Series SETTING:: Military Tertiary Referral Center PATIENTS:: Twenty-one operatively treated displaced FNSFs between 2002 and 2015.

Intervention: Urgent reduction and fixation was performed. If nonunion developed, an intertrochanteric osteotomy was performed. Read More

Orv Hetil 2020 05;161(21):867-872

Fogorvostudományi Kar, Arc-, Állcsont-, Szájsebészeti és Fogászati Klinika,Semmelweis Egyetem Budapest.

Introduction: Bisphosphonate-related osteonecrosis of the jaw is a condition that severely affects the quality of life, therefore an early diagnosis is of utmost importance (both from a general and a surgical point of view), alongside with an accurate assessment of the risk of emergence of the disease.

Aim: Estimation of the prognosis is not resolved; among several radiological options those used in dentistry seem the most fit for the purpose, with cone-beam computed tomography (CBCT) being superior in this task. Assessment of the risk of BRONJ developed following orally applied bisphosphonate is unemphatic in most case studies - these focus more on the intravenous application carrying a greater risk of BRONJ. Read More

Endocr Pract 2020 May;26(Suppl 1):1-46

The development of these guidelines is sponsored by the American Association of Clinical Endocrinologists (AACE) Board of Directors and American College of Endocrinology (ACE) Board of Trustees and adheres with published AACE protocols for the standardized production of clinical practice guidelines (CPGs). Recommendations are based on diligent reviews of the clinical evidence with transparent incorporation of subjective factors, according to established AACE/ACE guidelines for guidelines protocols. The Executive Summary of this 2020 updated guideline contains 52 recommendations: 21 Grade A (40%), 24 Grade B (46%), 7 Grade C (14%), and no Grade D (0%). Read More

J Orthop 2020 Nov-Dec;22:207-212. Epub 2020 May 6.

Department of Orthopaedics, Kasturba Hospital, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.

Objectives: Pediatric femoral neck fractures were reviewed to compare complications with the time of presentation.

Methods: 34 pediatric femoral neck fractures were studied to detect union time, avascular necrosis, premature physis fusion, and the neck-shaft angle. All complications were comparable between both groups. Read More

Orthop Surg 2020 May 18. Epub 2020 May 18.

Department of Orthopaedic Surgery, Amphia Hospital, Breda, The Netherlands.

Objectives: To assess the learning curve of the direct superior approach (DSA) for total hip arthroplasty (THA) and to compare surgical, clinical, and radiological results with a matched control group using the mini posterior approach (MPA).

Methods: A prospective cohort study was performed from October 2016 to May 2017 including our first 52 patients undergoing THA using the DSA. Patients with primary osteoarthritis or osteonecrosis and a body mass index (BMI) < 35 who were eligible for surgery were included. Read More

Int J Surg Case Rep 2020 May 7;70:234-237. Epub 2020 May 7.

Service de Traumatologie, CHRU Cavale Blanche, Brest, France. Electronic address:

Introduction: Fractures-dislocations of the femoral head are rare, and irreducible dislocations are even rarer. The functional prognosis is poor.

Presentation Of Case: We report the case of a 23-year-old male brought to the emergency room following low-energy trauma. Read More

Acta Biomed 2020 May 11;91(2):342-349. Epub 2020 May 11.

ASL TO5.

Background: Osteonecrosis of the femoral head (ONFH) is a frequent orthopedic disease leading to destruction of the hip joint and disabling arthritis. Several procedures have been developed to treat the joint deterioration in case of osteonecrosis, trying to avoid or delay an intervention of total hip replacement, especially in young patients. The aim of this study was to analyze the use of autologous bone micrografts derived from cancellous bone in the management of avascular ONFH. Read More

Am J Med Sci 2020 Apr 18. Epub 2020 Apr 18.

Department of Dentistry and Oral Surgery, Unit of Sensory and Locomotor Medicine, Division of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.

Clin Rheumatol 2020 May 16. Epub 2020 May 16.

Department of Rheumatology, Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Sheffield, S10 2JF, UK.

Panminerva Med 2020 May 14. Epub 2020 May 14.

Department of Cardiology, Wenzhou Central Hospital, Wenzhou, China.

Background: Acute myocardial infarction (AMI) is the myocardial avascular necrosis syndrome caused by coronary atherosclerotic plaque rupture, thrombosis or coronary artery occlusion. Therefore, it is of great significance to find new targets for the treatment of myocardial infarction. The purpose of this study was to investigate the effect of microRNA-379 (miR-379) on AMI and its mechanism. Read More

J Stomatol Oral Maxillofac Surg 2020 May 13. Epub 2020 May 13.

Department of oral and maxillo-facial surgery, 1200 Brussels, Belgium; Institut Roi Albert II, Cancérologie et Hématologie, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, avenue Hippocrate, 10, 1200 Brussels, Belgium. Electronic address:

MRONJ is a well-known side effect of various medications, such as antiresorptive drugs, anti-angiogenic agents, immunomodulators and immunosuppressants. MRONJ related to immunotherapy is rarely described, with only one case related to ipilimumab. The interaction between the immune system and osteoclast lineage cells is well known. Read More

Clin Exp Dermatol 2020 May 15. Epub 2020 May 15.

Department of Dermatology, Royal Alexandra Hospital, NHS Greater Glasgow & Clyde, Glasgow, UK.

J Orthop Surg Res 2020 May 14;15(1):173. Epub 2020 May 14.

Department of Orthopaedic Surgery, Hongze Huaian District People's Hospital, No. 102 Dongfeng Road, Hongze District, Huai'an City, 223100, Jiangsu Province, China.

Background: It is reported that miR-596 has a potential diagnostic value for non-traumatic osteonecrosis of the femoral head (NOFH), but its underlying mechanisms in NOFH is unclear.

Methods: The expression of miR-596 and Smad3 was detected by western blot and quantitative real-time PCR. The relationship between the two molecules was explored using Dual-Luciferase Reporter Assay. Read More

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2020 May;34(5):596-601

Department of Orthopeadics, the 920th Hospital of Joint Logistics Support Force, Kunming Yunnan, 650032, P.R.China.

Objective: To provide anatomical basis for vascularized pisiform transfer in the treatment of advanced avascular necrosis of the lunate (Kienböck's disease) by studying its morphology and blood supply pattern based on digital technique.

Methods: Twelve adult fresh wrist joint specimens were selected and treated with gelatin-lead oxide solution from ulnar or radial artery. Then the three-dimensional (3D) images of the pisiform and lunate were reconstructed by micro-CT scanning and Mimics software. Read More

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2020 May;34(5):579-584

Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, P.R.China.

Objective: To prospective study the effectiveness and safety of multimodal analgesia (MA) in treatment of avascular necrosis of the femoral head with free vascularized fibular grafting (FVFG).

Methods: Sixty patients with avascular necrosis of the femoral head, who were scheduled to unilateral primary FVFG between February 2016 and December 2016 and met the selection criteria, were included in the study. All patients were allocated to two groups according to the method of random number table: MA group ( =30) and control group ( =30). Read More

Injury 2020 May 8. Epub 2020 May 8.

RGMC, Kalwa Thane, India.

Avascular necrosis (AVN) of the femoral head is a progressive disease that generally affects patients in the second through fifth decades of life; if left untreated, it leads to complete deterioration of the hip joint. Treatments range from simple decompression of the femoral head, to muscle pedicle bone grafting of the involved area, or by using a vascularized fibular graft with varying degree of success. If the disease have progresses further causing secondary arthritis, Total Hip Arthroplasty may be necessary. Read More

Cancers (Basel) 2020 May 12;12(5). Epub 2020 May 12.

Department of Oral and Maxillofacial Surgery, Shimane University Faculty of Medicine, Shimane 693-8501, Japan.

This single-center retrospective observational study aimed to identify risk factors for developing denosumab-related osteonecrosis of the jaw (DRONJ) in stage IV solid cancer patients with bone metastases. In total, 123 consecutive patients who had received 120 mg of denosumab every 4 weeks at least twice between July 2014 and October 2018 were included. We surveyed their demographics, medical history, blood test, underlying disease, and intraoral findings. Read More