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Arthroscopy 2021 May 5. Epub 2021 May 5.

Department of Orthopaedics, Balgrist University Hospital, Forchstrasse 340, 8008 Zurich, Switzerland.

Purpose: To assess whether biologic augmentation in addition to core decompression (CD), compared to CD alone, improves clinical and radiographic outcomes in the treatment of nontraumatic osteonecrosis of the femoral head (ONFH). Our hypothesis was that biologic augmentation would reduce the progression of osteonecrosis and therefore also the rate of conversion to THA.

Methods: A systematic review was performed in accordance with the Preferred Reporting Items of Systematic Reviews and Meta-analysis (PRISMA) statement. Read More

Int Orthop 2021 May 8. Epub 2021 May 8.

Head of Foot and Ankle Surgery Group, Orthopaedics and Traumatology Unit, Prevent Senior, São Paulo, Brazil.

Background: Hindfoot arthrodesis is used in patients with advanced-stage acquired flatfoot, usually associated with degenerative joint disease. The objective of the present study was to evaluate the clinical and radiographic results of hindfoot arthrodesis using the single-incision medial approach.

Methods: A case series of 18 consecutive patients undergoing surgical correction between 2015 and 2018 with hindfoot arthrodesis using the medial approach was evaluated. Read More

Acta Chir Orthop Traumatol Cech 2021 ;88(2):153-157

Istanbul Medeniyet University, Department of Orthopaedic Surgery and Traumatology, Istanbul, Turkey.

PURPOSE OF THE STUDY To investigate the pressure levels on the axillary nerve at different plate positions after plate fixation of a proximal humerus fracture. MATERIAL AND METHODS Eight fresh-frozen cadaveric specimens were used. The plates were applied on the lateral side of the humerus. Read More

Osteoarthr Cartil Open 2021 Jun 16;3(2). Epub 2021 Apr 16.

Boston University School of Medicine, Boston, MA, USA.

Background: Anti-nerve growth factor (NGF) has shown promise for osteoarthritis (OA) pain efficacy, but an unanticipated joint safety signal occurred in trials. To what extent this was related to OA natural history, or was a consequence of anti-NGF agents is unclear. Of the adverse joint safety events identified, osteonecrosis has specific diagnostic codes available in the medical record to enable assessment of its frequency in the general community. Read More

Expert Rev Clin Immunol 2021 May 6. Epub 2021 May 6.

Department of Rheumatology, Fujian Provincial Hospital, Fuzhou, China.

Objectives: : The present meta-analysis aimed to assess the relationship between antiphospholipid antibodies (aPLs) or antiphospholipid antibody syndrome (APS) and the incidence of osteonecrosis (ON) in systemic lupus erythematosus (SLE) patients.

Methods: : MEDLINE/Pubmed, EMBASE, Web of science, the Chinese Biomedical Literature Database (CBM), the Wan-Fang Database, and the China National Knowledge Infrastructure (CNKI) were searched from their inception up until 26 December 2020. Studies in English were included. Read More

J Orthop Case Rep 2020 May-Jun;10(3):95-99

Department of Trauma and Orthopaedic Surgery, Faculty of Medicine, Cairo University, Giza, Egypt.

Introduction: Femoral neck fractures can complicate by non-union and/or hip avascular necrosis (AVN); moreover, the incidence of AVN remains obscure when it is accompanied by an ipsilateral acetabular fracture. Measures to reduce non-union or hip AVN with this complex injury pattern are not well addressed in the literature.

Case Report: We report a case of a young male patient who sustained ipsilateral acetabular, femoral neck, and shaft fractures in addition to a contralateral floating knee injury following a motor vehicle collision. Read More

J Orthop Case Rep 2020 May-Jun;10(3):71-75

Department of Orthopaedic Surgery, Dr. B.R Ambedkar Central Railway Hospital, Byculla, Mumbai, Maharashtra, India.

Introduction: Leprosy is a chronic granulomatous infection, classically presents with cutaneous and neurological manifestations. Joint involvement in leprosy can present as acute symmetrical or chronic polyarthritis with or without tenosynovitis resembling rheumatoidarthritis.

Case Report: We report a rare case of lepromatous hip arthritis in a 32-year-old male, known case of leprosytenosynovitis and symmetrical polyarthritis of hands and feet 3 weeks after appearance of typical cutaneous lesion. Read More

J Orthop Case Rep 2020 May-Jun;10(3):63-66

Department of Orthopaedic Surgery, Sri Ramachandra Medical College and Research Institute, Sri Ramachandra Institute of Higher Education and Research, Chennai, TamilNadu, India.

Introduction: Combined subtrochanteric femur fracture with anterior dislocation of hip is a very rare injury to occur with subminimal reported cases available in the literature. This study report describes one such unusual case presentation.

Case Report: A 26-year-old gentleman presented to our emergency room following road traffic accident, complained of severe pain over his right hip and inability to move his right lower limb. Read More

Case Rep Orthop 2021 14;2021:6633690. Epub 2021 Apr 14.

Department of Orthopedics, Centro Hospitalar e Universitário do Porto, Portugal.

Shoulder hemiarthroplasty is a viable option in young patients with an intact rotator cuff in order to preserve the native glenoid. To avoid the dreaded and expected wear of the glenoid in very active shoulders, implants with humeral head coated with a high resistant and elastic material-pyrolytic carbon-are now an option. The authors present the first pyrocarbon coated hemishoulder arthroplasty performed at our Orthopedic Department in a patient with osteonecrosis of the humeral head. Read More

Acta Med Okayama 2021 Apr;75(2):115-123

The survey and research-planning committee, Japanese Society for Dentistry of Medically Compromised Patient.

The aim of this study was to investigate the awareness and experience, among dental practitioners, of adverse events resulting from dental treatment of patients undergoing therapy with drugs that affect the immune system [angiogenesis inhibitors, biological agents, immunosuppressants, and disease-modifying anti-rheumatic drugs (DMARDs)]. For this purpose, a nationwide questionnaire survey was conducted. Questionnaires were sent to 2,050 dentists, of which 206 (10. Read More

Medicine (Baltimore) 2021 May;100(18):e25779

Department of Neurological Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.

Rationale: Systemic lupus erythematosus (SLE) is an important cause of stroke, more than a half the cases present as acute ischemic stroke. Thrombolysis is an effective choice in most cases, but for large vessel occlusion, mechanical thrombectomy is more effective. Here we reported a case of SLE-related stroke with left middle cerebral artery (MCA) occlusion, who was successfully treated by MT and tirofiban. Read More

Arthroplast Today 2021 Apr 16;8:247-252. Epub 2021 Apr 16.

Department of Orthopaedics and Traumatology, AZ Sint-Dimpna, Geel, Province Antwerp, Belgium.

Combined intracapsular and extracapsular fractures of the proximal femur-segmental fractures of neck of femur (SFNOF)-are rare and complex injuries. Literature regarding SFNOF is very limited; only one small retrospective study and 19 unique case reports have been described. We report the case of a 42-year-old man who suffered a compound subcapital femur fracture type Garden IV and an ipsilateral multifragmentary greater trochanter fracture from severe crush trauma. Read More

J Hip Preserv Surg 2020 Aug 29;7(3):466-473. Epub 2020 Oct 29.

Department of Anesthesiology, Aichi Children's Health and Medical Center, Cincinnati, Ohbu City, Aichi 474-8710, Japan.

The Japanese Orthopaedic Association Hip Disease Evaluation Questionnaire (JHEQ) was created for patient-reported outcome measures (PROMs) and to evaluate the conditions of patients with hip disease. Nevertheless, the validity of the JHEQ for patients with hip labral tears remains unclear. Therefore, we validated the JHEQ in patients with labral tears. Read More

J Hip Preserv Surg 2020 Aug 23;7(3):458-465. Epub 2020 Dec 23.

Department of Orthopaedics & Orthopaedic Surgery, Saarland University, Kirrberger Strasse 100, Homburg 66421, Germany.

This study's purpose is to arthroscopically assess the occurrence of intraarticular pathologies in patients with osteonecrosis of the femoral head (OFNH) and to compare arthroscopic with radiologic findings. In a retrospective cohort analysis of ONFH patients undergoing combined core decompression (CD) and hip arthroscopy, concomitant intraarticular pathologies were qualitatively and quantitatively assessed by means of arthroscopy. Intraoperative findings were compared with preoperative radiodiagnostics. Read More

J Hip Preserv Surg 2020 Aug 22;7(3):423-438. Epub 2020 Nov 22.

Department of Orthopaedics, PGIMER, Chandigarh 160012, India.

Head preserving modalities in avascular necrosis (AVN) hip are variably effective in early stages, and further options that could prevent head distortion and osteoarthritis are needed. Core decompression (CD) is the most commonly used surgery in the early stages of osteonecrosis with variable rates of success. The present review aimed to determine the effectiveness of bone marrow aspirate concentrate (BMAC), platelet-rich plasma (PRP), bone morphogenetic proteins (BMP) or their combination with CD in early stages of AVN hip, prior to collapse of femoral head. Read More

BMC Surg 2021 May 4;21(1):233. Epub 2021 May 4.

Department of Orthopaedics, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing, 100853, China.

Background: The treatment of a displaced proximal humeral fracture is still a matter of controversy. The purpose of this study was to report outcomes at a long-term follow-up after fixation augmentation using peek (polyether-ether-ketone) cage and locking compression plate (LCP).

Methods: A total of 27 patients (average age 53. Read More

Dent J (Basel) 2021 Apr 30;9(5). Epub 2021 Apr 30.

Department of Biomolecular Sciences, Maxillofacial Surgery, University of Mississippi, Jackson, MS 39216, USA.

Medication-related osteonecrosis of the jaw (MRONJ) frequently affects patients after treatments with bisphosphonates or denosumab, especially with high doses in patients with bone osteoporosis, neoplastic metastases, or possibly anti-angiogenic treatment for cancer. The aim of this article was to show a new treatment planning for stage 2 and stage 3 MRONJ using platelet-rich fibrin (PRF) at the surgical field to enhance healing in association with a new epi-mucosal fixation technique to prevent or treat mandibular fracture. Two cases were treated by epi-mucosa fixation and autologous PRF use for prevention of mandibular fracture risks related to necrotic bone resection or a narrow fracture reduction. Read More

J Cell Mol Med 2021 May 3. Epub 2021 May 3.

Department of Orthopedics, Guizhou Provincial People's Hospital, Guiyang, China.

Glucocorticoid-induced osteonecrosis of the femoral head (GIONFH) is a common orthopaedic disease. GIONFH primarily manifests clinically as hip pain in the early stages, followed by the collapse of the femoral head, narrowing of the hip joint space and damage to the acetabulum, resulting in severely impaired mobility. However, the pathogenesis of GIONFH is not clearly understood. Read More

Clin Case Rep 2021 Apr 11;9(4):2205-2209. Epub 2021 Mar 11.

Internal Medicine Department Faculty of Medicine of Tunis Habib Thameur Hospital University of Tunis el Manar Tunis Tunisia.

Osteonecrosis in antiphospholipid syndrome is a diagnostic challenge for clinicians. Early diagnosis and intervention are important for better prognosis. Read More

Drug Des Devel Ther 2021 23;15:1717-1724. Epub 2021 Apr 23.

Department of Orthopedics, Minhang Hospital, Fudan University, Shanghai, 201199, People's Republic of China.

Background: Osteonecrosis of the femoral head (ONFH) seriously affects the quality of life and labor ability of patients. It is urgent and vital to find the methods for necrosis clinical treatment.

Objective: This study aims to study the potential protective effects of Alendronate in the early stage of femur head necrosis. Read More

Rev Bras Ortop (Sao Paulo) 2021 Apr 22;56(2):133-137. Epub 2020 Jul 22.

Departamento de Ortopedia e Traumatologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.

Medial arthrosis of the knee is an evolutionary pathology that occurs due to progressive muscle imbalance. The muscles of the knee region have a large imbalance caused by the difference of power and lever arm. With the progression of life, this imbalance manifests itself more importantly, especially due to the loss of muscle strength due to aging. Read More

Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Mar 14. Epub 2021 Mar 14.

Ordinary Professor, Maxillo‑Facial Surgery, Department of Medicine and Surgery, University of Perugia, Perugia, Italy; Chief of Maxillo-Facial Surgery Unit, Santa Maria Della Misericordia Hospital, San Sisto, Perugia, Italy.

Objective: The aim of this systematic review was to describe the quality of life and oral health-related quality of life of patients affected by medication-related osteonecrosis of the jaw.

Study Design: The review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A combination of keywords and MeSH terms was used in PubMed, Scopus, Cochrane Library, Web of Science, and EBSCO up to December 13, 2020. Read More

Bone Joint J 2021 May;103-B(5):999-1004

Department of Orthopaedic Surgery, Sophia's Children's Hospital, Erasmus University Medical Centre, Rotterdam, The Netherlands.

Aims: The most important complication of treatment of developmental dysplasia of the hip (DDH) is avascular necrosis (AVN) of the femoral head, which can result in proximal femoral growth disturbances leading to pain, dysfunction, and eventually to early onset osteoarthritis. In this study, we aimed to identify morphological variants in hip joint development that are predictive of a poor outcome.

Methods: We retrospectively reviewed all patients who developed AVN after DDH treatment, either by closed and/or open reduction, at a single institution between 1984 and 2007 with a minimal follow-up of eight years. Read More

Eur J Cancer 2021 Apr 29;150:211-213. Epub 2021 Apr 29.

Department of Pharmacy, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China. Electronic address:

J Craniomaxillofac Surg 2021 Apr 20. Epub 2021 Apr 20.

Department of Oral and Maxillofacial Surgery, Hacettepe University, Ankara, Turkey.

The aim of this study was to focus on the MRONJ-related pathologic fractures, their incidence, and to analyze possible causative factors for their occurrence. Pathologic fracture in patients suffering frm MRONJ were identified, examined in detail, and the patient characteristics were evaluated. In 116 patients (73 female and 43 male; mean age 62. Read More

J Stomatol Oral Maxillofac Surg 2021 Apr 27. Epub 2021 Apr 27.

Faculté d'odontologie de Rennes, Université de Rennes 1, 2 avenue du Professeur Léon Bernard, 35043 Rennes, France; Centre de Soins Dentaires de Rennes, Centre Hospitalier Universitaire de Rennes, 2 Rue Henri le Guilloux, 35033 Rennes cedex 9, France. Electronic address:

Introduction: A cross-sectional study by questionnaire was performed to evaluate the knowledge of French dentists about bone resorption inhibitors (BRIs) and medication-related osteonecrosis of the jaw (MRONJ).

Materials And Methods: 498 digital questionnaires were collected and 358 complete responses of French dental practionners in active practice except for orthodontists were analyzed. Descriptive analysis was computed and categorical variables were compared by Z test. Read More

Life Sci 2021 Apr 27:119548. Epub 2021 Apr 27.

Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, PR China. Electronic address:

Aims: Adipocyte-secreted microvesicles (MVs)-derived microRNAs (miRNAs) are relevant to adipogenic and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) in osteonecrosis of the femoral head (ONFH). Our aims are to investigate the mechanism of adipocyte-derived MVs-miR-148a in ONFH.

Materials And Methods: Adipocyte-derived MVs were identified via transmission electron microscopy and specific markers expression. Read More

Biomed Res Int 2021 7;2021:6655225. Epub 2021 Apr 7.

Department of Orthopedics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province 710061, China.

Recent studies have suggested that exosomes exert similar therapeutic effects to those of mesenchymal stem cells (MSCs) in regenerative medicine and MSCs-derived exosomes exhibit therapeutic effects on steroid-induced osteonecrosis of the femoral head (ONFH). Furthermore, reparative functions of exosomes from MSCs are enhanced by hypoxia treatment of the cells. However, there are no related reports about whether exosomes derived from hypoxia-preconditioned MSCs could show better therapeutic effects on steroid-induced ONFH. Read More