88,602 results match your criteria Autopsy Rate and Physician Attitudes Toward Autopsy


Pleural anthracosis presenting with massive effusion: a rare entity.

Respirol Case Rep 2019 Feb 28;7(2):e00390. Epub 2018 Nov 28.

Respiratory Department Universiti Kebangsaan Malaysia Medical Centre Kuala Lumpur Malaysia.

Pleural anthracosis is rare and, in most cases, is diagnosed incidentally or at autopsy. We report a 67-year-old man with pleural anthracosis. He was initially referred for possible tuberculous pleural effusion and had recurrent admissions for symptomatic pleural effusion, which increased with each subsequent episode. Read More

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February 2019

Siglec-1 Macrophages and the Contribution of IFN to the Development of Autoimmune Congenital Heart Block.

J Immunol 2018 Dec 5. Epub 2018 Dec 5.

Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, NY 10016.

Given that diseases associated with anti-SSA/Ro autoantibodies, such as systemic lupus erythematosus and Sjögren syndrome, are linked with an upregulation of IFN and type I IFN-stimulated genes, including sialic acid-binding Ig-like lectin 1 (Siglec-1), a receptor on monocytes/macrophages, recent attention has focused on a potential role for IFN and IFN-stimulated genes in the pathogenesis of congenital heart block (CHB). Accordingly, three approaches were leveraged to address the association of IFN, IFN-stimulated genes, and the phenotype of macrophages in affected fetal cardiac tissue: 1) cultured healthy human macrophages transfected with hY3, an anti-SSA/Ro-associated ssRNA, 2) RNA isolated from freshly sorted human leukocytes/macrophages after Langendorff perfusion of three fetal hearts dying with CHB and three healthy gestational age-matched hearts, and 3) autopsy tissue from three additional human CHB hearts and one healthy heart. TLR ligation of macrophages with hY3 led to the upregulation of a panel of IFN transcripts, including SIGLEC1, a result corroborated using quantitative PCR. Read More

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December 2018

Magnitude, trends and causes of maternal mortality among reproductive aged women in Kersa health and demographic surveillance system, eastern Ethiopia.

BMC Womens Health 2018 Dec 5;18(1):198. Epub 2018 Dec 5.

Mothers and Babies Research Centre, Faculty of Health and Medicine, University of Newcastle, Newcastle, Australia.

Background: Despite efforts at curbing maternal morbidity and mortality, developing countries are still burdened with high rates of maternal morbidity and mortality. Ethiopia is not an exception and has one of the world's highest rates of maternal deaths. Reducing the huge burden of maternal mortality remains the single most serious challenge in Ethiopia. Read More

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December 2018
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Association of Cerebrospinal Fluid Neurofilament Light Protein Levels With Cognition in Patients With Dementia, Motor Neuron Disease, and Movement Disorders.

JAMA Neurol 2018 Dec 3. Epub 2018 Dec 3.

Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.

Importance: Neuronal and axonal destruction are hallmarks of neurodegenerative diseases, but it is difficult to estimate the extent and progress of the damage in the disease process.

Objective: To investigate cerebrospinal fluid (CSF) levels of neurofilament light (NFL) protein, a marker of neuroaxonal degeneration, in control participants and patients with dementia, motor neuron disease, and parkinsonian disorders (determined by clinical criteria and autopsy), and determine its association with longitudinal cognitive decline.

Design, Setting, And Participants: In this case-control study, we investigated NFL levels in CSF obtained from controls and patients with several neurodegenerative diseases. Read More

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December 2018

Global, regional, and national burden of tuberculosis, 1990-2016: results from the Global Burden of Diseases, Injuries, and Risk Factors 2016 Study.

Authors:

Lancet Infect Dis 2018 Dec;18(12):1329-1349

Background: Although a preventable and treatable disease, tuberculosis causes more than a million deaths each year. As countries work towards achieving the Sustainable Development Goal (SDG) target to end the tuberculosis epidemic by 2030, robust assessments of the levels and trends of the burden of tuberculosis are crucial to inform policy and programme decision making. We assessed the levels and trends in the fatal and non-fatal burden of tuberculosis by drug resistance and HIV status for 195 countries and territories from 1990 to 2016. Read More

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December 2018
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Global, regional, and national burden of meningitis, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.

Authors:

Lancet Neurol 2018 Dec 13;17(12):1061-1082. Epub 2018 Nov 13.

Background: Acute meningitis has a high case-fatality rate and survivors can have severe lifelong disability. We aimed to provide a comprehensive assessment of the levels and trends of global meningitis burden that could help to guide introduction, continuation, and ongoing development of vaccines and treatment programmes.

Methods: The Global Burden of Diseases, Injuries, and Risk Factors (GBD) 2016 study estimated meningitis burden due to one of four types of cause: pneumococcal, meningococcal, Haemophilus influenzae type b, and a residual category of other causes. Read More

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December 2018

Extracellular traps derived from macrophages, mast cells, eosinophils and neutrophils are generated in a time-dependent manner during atherothrombosis.

J Pathol 2018 Dec 2. Epub 2018 Dec 2.

Department of Pathology, Amsterdam UMC, University of Amsterdam, Netherlands.

Extracellular traps generated by neutrophils contribute to thrombus progression in coronary atherosclerotic plaques. It is not known whether other inflammatory cell types in coronary atherosclerotic plaque or thrombus also release extracellular traps. We investigated their formation by macrophages, mast cells and eosinophils in human coronary atherosclerosis, and in relation to the age of thrombus of myocardial infarction patients. Read More

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December 2018

Simon's hemorrhages in a case of a fatal construction site accident as the result of body hyperextension in the upside-down position - a possible reconstruction of the injury mechanism.

Forensic Sci Med Pathol 2018 Dec 1. Epub 2018 Dec 1.

Institute of Forensic Medicine, University of Belgrade - School of Medicine, 31a Deligradska str., Belgrade, 11000, Serbia.

An accident occurred at a construction site and a 27-year-old worker was fatally injured. Equipped with personal protective equipment (helmet and a safety belt), he was standing on an 8-meter-high platform holding a large hose that was attached to a pipe connected to a concrete pump truck. Whilst in use the pipe broke and the hose sent the man flying with force, knocking down the platform railing. Read More

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December 2018

Stromal Content Is Correlated With Tissue Site, Contrast Retention, and Survival in Pancreatic Adenocarcinoma.

JCO Precis Oncol 2018 16;2018. Epub 2018 Jan 16.

Department of Medicine, University of California, San Francisco, USA.

Purpose: Desmoplastic stroma is a cardinal feature of primary pancreatic ductal adenocarcinoma (PDAC), but its effects on the biology, prognosis and therapeutic outcomes are not known. We developed an automated method to assess tumor stroma density (TSD) and investigated computed tomography (CT)-correlates of stroma in PDAC.

Patients And Methods: We collected PDAC samples from rapid autopsy and resection series and digitally annotated samples to quantify TSD. Read More

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January 2018

Complete Routine Remote Digital Pathology Services.

J Pathol Inform 2018 29;9:36. Epub 2018 Oct 29.

Department of Pathology, Førde Central Hospital, Førde, Norway.

Background: Validation studies in digital pathology addressed so far diverse aspects of the routine work. We aimed to establish a complete remote digital pathology service.

Methods: Altogether 2295 routine cases (8640 slides) were reported in our studies on digital versus microscopic diagnostics, remote reporting, diagnostic time, fine-needle aspiration cytology (FNAC) clinics, frozen sections, and diagnostic sessions with residents. Read More

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October 2018

Visceral Mycoses in Autopsied Cases in Japan from 1989 to 2013.

Med Mycol J 2018 ;59(4):E53-E62

Department of Pathology, Kitasato University School of Medicine.

Background And Methods: Our group has continuously studied the epidemiology of visceral mycoses (VM) among autopsy cases in Japan from 1989 to 2013.

Results: First, from a total of 11,149 autopsied cases, 571 (5.1%) cases of VM were observed in 2013. Read More

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January 2018

Autopsy in dengue encephalitis: An analysis of three cases.

Neurol India 2018 Nov-Dec;66(6):1721-1725

Department of Pathology and Neurology, Command Hospital Air Force, Bengaluru, Karnataka, India.

Dengue viral infection with unusual presentations has been described in literature, but autopsy is rarely done and is only limited to some cases, based on the literature review. Here, we present the autopsy findings in three cases of dengue encephalitis. All the three patients clinically presented with signs of meningoencephalitis and were positive for dengue non-structural (NS) 1 antigen (Ag) in the serum and cerebrospinal fluid. Read More

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December 2018

Sudden and unexpected death due to intracranial sellar extramedullary plasmacytoma.

J Forensic Leg Med 2018 Nov 26;61:89-91. Epub 2018 Nov 26.

Institute od Pathology, Faculty of Medicine, Slovak Medical University and Cytopathos Ltd., Limbova 12, 833 03 Bratislava, Slovakia. Electronic address:

The incidence of sudden death caused by undiagnosed primary intracranial neoplasm in young adults is extremely low. The aim of the work is to present a case report of the sudden death of a 24-year-old woman. The autopsy has revealed enlargement of sella turcica with an intrasellar tumorous mass extending into the adjacent basal parts of the brain. Read More

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November 2018
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Hematopoietic cell transplantation for severe MPS I in the first six months of life: The heart of the matter.

Mol Genet Metab 2018 Nov 13. Epub 2018 Nov 13.

Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, United States.

Background: Hematopoietic cell transplantation (HCT) is accepted therapy for severe mucopolysaccharidosis type I (MPS IH). With implementation of newborn screening (NBS) for MPS I in the US, HCT may now occur earlier than 1-2 years of age and it might be assumed that cardiac issues will be fewer. To examine this hypothesis, we reviewed our records for any MPS IH infant who underwent HCT at ≤6 months of age. Read More

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November 2018

Do Autopsies Still Matter? The Influence of Autopsy Data on Final Injury Severity Score Calculations.

J Surg Res 2019 Jan 22;233:453-458. Epub 2018 Sep 22.

Division of Trauma and Burns, Department of Surgery, Harborview Medical Center, University of Washington, Seattle, Washington. Electronic address:

Background: Despite a proven record of identifying injuries missed during clinical evaluation, the effect of autopsy on injury severity score (ISS) calculation is unknown. We hypothesized that autopsy data would alter final ISS and improve the accuracy of outcome data analyses.

Materials And Methods: All trauma deaths from January 2010 through June 2014 were reviewed. Read More

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January 2019

Diabetes insipidus secondary to tuberculous meningoencephalitis with hypothalamic involvement extending to the hypophysis: a case report.

Rev Soc Bras Med Trop 2018 Nov-Dec;51(6):865-867

Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, AM, Brasil.

The involvement of Mycobacterium tuberculosis in the central nervous system (CNS) is an uncommon and devastating manifestation of tuberculosis. We report a case of disseminated tuberculosis presenting as meningoencephalitis, hypothalamic involvement with extension to the hypophysis, and secondary insipidus diabetes diagnosed at autopsy. Read More

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December 2017

Rearward movement of the slide in semi-automatic pistols: a factor potentially influencing the configuration of muzzle imprint marks in contact shots.

Int J Legal Med 2018 Dec 4. Epub 2018 Dec 4.

Institute of Legal Medicine, University Medical Center, Faculty of Medicine, University of Freiburg, Albertstraße 9, 79104, Freiburg, Germany.

A muzzle imprint mark is a highly diagnostic finding, which indicates a contact shot. In many cases, it also provides additional information on the type of the weapon used and on the way in which it was held at the time of firing. In semi-automatic pistols, some constructional elements constituting the muzzle plane move to the rear together with the slide, which may prevent them from causing a corresponding imprint close to the bullet entrance hole. Read More

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December 2018
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Assessment of the Prevalence of Vascular Anomalies of the Circle of Willis Based on the Autopsy of Cadavers in Kurdish Race Between 2016 and 2017.

Mater Sociomed 2018 Oct;30(3):189-192

Department of Neurosurgery, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Introduction: Cerebral arterial variations are commonly associated with cerebrovascular disease and should be considered during brain surgeries. Since some cerebrovascular diseases are seen in certain breeds, it seems that different distributions of cerebral arterial variations depend on race.

Aim: The aim of this study was to determine the random incidence of vascular anomalies of the circle of Willis in autopsy of the cadavers. Read More

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October 2018

Correlation of height and maximum overhead reach of a person in the forensic scenario: A study among the North Indian population.

Med Sci Law 2018 Dec 4:25802418816283. Epub 2018 Dec 4.

Department of Forensic Medicine, ESIC Medical College, India.

This study formulated a regression equation to estimate the maximum overhead reach of a person using his/her height. Height and maximum overhead reach of participants aged 21-30 years were measured. A regression equation was formulated to find the relation between height and maximum overhead reach. Read More

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December 2018

Une épidémie de cancers due au surdiagnostic.

Rev Prat 2017 Jun;67(6):668-672

service de médecine nucléaire institut Gustave- Roussy, université Paris-Saclay, Inserm U1018, Villejuif, France.

Epidemiology of thyroid cancer. There is an important increase in the frequency of thyroid cancer in France, even after taking into account population increase and aging. This increase is essentially due to overdiagnosis. Read More

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Systemic Dissemination of Injected Foreign Material.

J Forensic Sci 2018 Dec 4. Epub 2018 Dec 4.

Forensic Science SA, GPO Box 2790, Adelaide, 5001.

A 32-year-old woman collapsed following an intravenous injection of material that included crushed pharmaceutical tablets. Resuscitation was attempted but was unsuccessful. She had an extensive past medical history of complications resulting from intravenous drug use. Read More

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December 2018
3 Reads

Prenatal and postnatal presentation of PRMT7 related syndrome: Expanding the phenotypic manifestations.

Am J Med Genet A 2018 Dec 4. Epub 2018 Dec 4.

Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel.

Protein arginine methyltransferase 7 (PRMT7) is a member of a family of enzymes that catalyze the transfer of methyl groups from S-adenosyl-l-methionine to nitrogen atoms on arginine residues. Arginine methylation is involved in multiple biological processes, such as signal transduction, mRNA splicing, transcriptional control, DNA repair, and protein translocation. Currently, 10 patients have been described with mutations in PRMT7. Read More

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December 2018
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Discussion: Understanding Fatal Fat Embolism in Gluteal Lipoinjection: A Review of the Medical Records and Autopsy Reports of 16 Patients.

Plast Reconstr Surg 2018 Nov;142(5):1209-1211

Santa Monica, Calif. From the David Geffen School of Medicine at University of California, Los Angeles.

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November 2018

An autopsy case of progressive multifocal leukoencephalopathy after rituximab therapy for malignant lymphoma.

Neuropathology 2018 Dec 3. Epub 2018 Dec 3.

Department of Pathology, Kurume University School of Medicine, Kurume, Japan.

Progressive multifocal leukoencephalopathy (PML) is a rare fatal demyelinating disease of the central nervous system caused by reactivation of the JC virus (JCV), which is named after the initials of the patient from whom the virus was first isolated. JCV is highly prevalent worldwide, infects humans in early childhood, and the infection persists throughout the course of life in latent form. The present paper deals with the second autopsy case report of rituximab-associated PML in Japan. Read More

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December 2018
2 Reads

Amyotrophic lateral sclerosis of long clinical course clinically presenting with progressive muscular atrophy.

Neuropathology 2018 Dec 3. Epub 2018 Dec 3.

Department of Neurology, Mifukai Vihara Hananosato Hospital, Hiroshima, Japan.

Amyotrophic lateral sclerosis (ALS) primarily affects upper and lower motor neurons. Phosphorylated trans-activation response DNA-binding protein of 43 kDa (TDP-43) inclusion bodies are reportedly a pathological hallmark of sporadic ALS. Here, we present an atypical case of sporadic ALS that progressed very slowly, persisted for 19 years, and clinically appeared to only affect the lower motor neurons; however, upper motor neuron degeneration was detected at autopsy. Read More

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December 2018

A controlled inflammation and a regulatory immune system are associated with more favorable prognosis of progressive multifocal leukoencephalopathy.

J Neurol 2018 Dec 3. Epub 2018 Dec 3.

Department of Neurology and Neurological Science, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, 1-5-45 Yushima Bunkyo-ku, Tokyo, 113-8510, Japan.

Objective: In the present study, we analyzed the inflammatory profiles of brain tissues obtained from patients with progressive multifocal leukoencephalopathy (PML) due to John Cunningham (JC) virus infection to identify potential prognostic factors.

Methods: The study included seven patients (two men, five women) who had been pathologically diagnosed with PML, and all of whom were HIV negative. Fixed brain samples were analyzed via hematoxylin and eosin (HE) staining and Klüver-Barrera (KB) staining. Read More

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December 2018

Histopathological liver findings in patients with hepatocerebral mitochondrial depletion syndrome with defined molecular basis.

Pol J Pathol 2018 ;69(3):292-298

Mitochondrial DNA depletion consisting of the systemic reduction of mtDNA copy number in cells may have a heterogenous genetic basis, resulting from a pathogenic change in the nuclear genes involved in mtDNA synthesis. The mode of inheritance is autosomal recessive. Severe hepatocerebral disease represents one of many different clinical forms of so-called mitochondrial depletion syndrome (MDS). Read More

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January 2018

Pathologic and molecular studies of enterovirus 71 infection in a fatal case from a recent epidemic in China: A case report.

Medicine (Baltimore) 2018 Nov;97(48):e13447

Zhejiang Key Laboratory of Pathophysiology, Department of Pathology and Pathogen Biology, Medical School of Ningbo University.

Rationale: Enterovirus 71 (EV71) is identified as the primary cause of hand, foot, and mouth disease (HFMD) and mainly infects the young infants. Though some fatal cases have been reported, the underlying mechanisms of EV71 infection remain elusive and more further pathologic and molecular studies of EV71 infection are needed.

Patient Concerns: A 26-month-old girl with a history of fever and lethargy for 3 days and intermittent seizures for 2 hours associated with rash on 4 limbs was brought to a hospital. Read More

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November 2018
2 Reads

Investigating the characteristics of echocardiogram, surgical treatment, chromosome and prognosis for fetal right heart enlargement: A STROBE-compliant article.

Medicine (Baltimore) 2018 Nov;97(48):e13307

Department of Cardiovascular Ultrasound, Henan Provincial People's Hospital, China.

The prognosis of right heart enlargement varies according to different etiologies. The purpose of this study was to investigate the characteristics of echocardiogram, surgical treatment, chromosome and prognosis for fetal right heart enlargement.The foetal echocardiogram was performed on 3987 pregnant women, and then 88 fetuses with right heart enlargement were identified. Read More

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November 2018
1 Read

Fatal combination of mitragynine and quetiapine - a case report with discussion of a potential herb-drug interaction.

Authors:
Rhome L Hughes

Forensic Sci Med Pathol 2018 Nov 29. Epub 2018 Nov 29.

University of North Dakota School of Medicine and Health Sciences, 1301 N. Columbia Rd (Room W430), Grand Forks, ND, 58203, USA.

Kratom is a plant with dose-dependent mixed stimulant and opioid properties whose pharmacologic characteristics and social impact continue to be described. The main active isolate of kratom is mitragynine, an indole-containing alkaloid with opioid-like effects. Kratom toxicity and kratom-associated fatalities have been described, including those in association with additional drugs. Read More

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November 2018
1 Read

Forensic Radiology: An Update.

J Belg Soc Radiol 2017 Dec 16;101(Suppl 2):21. Epub 2017 Dec 16.

University of Foggia, IT.

Forensic radiology is a specialized area of medical imaging using radiological techniques to assist physicians and pathologists in matters related to the law. The forensic application of diagnostic medical radiology can be applied in many fields; the prime target of evaluation is the osseous skeleton, but soft tissues and abdominal and thoracic viscera may offer key findings. The technological progress in clinical radiology provides a lot of potential tools to forensic radiology, allowing wider fields of applications in this matter. Read More

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December 2017

Global, regional, and national estimates of pneumonia morbidity and mortality in children younger than 5 years between 2000 and 2015: a systematic analysis.

Lancet Glob Health 2018 Nov 26. Epub 2018 Nov 26.

Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK; Public Health Foundation of India, Gurgaon, India. Electronic address:

Background: Global child mortality reduced substantially during the Millennium Development Goal period (2000-15). We aimed to estimate morbidity, mortality, and prevalence of risk factors for child pneumonia at the global, regional, and national level for developing countries for the Millennium Development Goal period.

Methods: We estimated the incidence, number of hospital admissions, and in-hospital mortality due to all-cause clinical pneumonia in children younger than 5 years in developing countries at 5-year intervals during the Millennium Development Goal period (2000-15) using data from a systematic review and Poisson regression. Read More

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November 2018

A Treatise on the Epidemic Cholera; Containing Its History, Symptoms, Autopsy, Etiology, Causes, and Treatment.

Lond Med Phys J 1833 Apr;14(82):265-283

the Honourable East-India Company's Service; Member of the Royal Asiatic Society of Great Britain and Ireland, of the Wernerian and Royal Medical Societies of Edinburgh, &c.

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A Treatise on the Epidemic Cholera; Containing Its History, Symptoms, Autopsy, Etiology, Causes, and Treatment.

Lond Med Phys J 1833 May;14(83):353-365

the Honourable East-India Company's Service; Member of the Royal Asiatic Society of Great Britain and Ireland, of the Wernerian and Royal Medical Societies of Edinburgh, &c.

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On the Autopsy of Epidemic Cholera.

Lond Med Phys J 1833 Jul;15(85):3-15

the Honourable East-India Company's Service; Member of the Royal Asiatic Society of Great Britain and Ireland, of the Wernerian and Royal Medical Societies of Edinburgh, &c.

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Unexpected sudden death in pregnancy - arrhythmogenic right ventricular cardiomyopathy/dysplasia: a case report.

Forensic Sci Res 2017 23;2(3):161-163. Epub 2017 May 23.

Forensic Unit, Teaching Hospital Kandy, Kandy, Sri Lanka.

Cardiovascular disease is an important contributor to maternal mortality in both developing and developed countries. Systematic search for cardiac disease is usually not performed during pregnancy despite hypertensive disease, undiagnosed pulmonary hypertension and cardiomyopathies being recognized as major health problems in these settings. This article reported a 27-year-old female who was normal on clinical examination and basic investigations, and on an antenatal visit was found collapsed in the toilet of her house and was pronounced dead on admission to hospital. Read More

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May 2017
2 Reads

Astrocytic clasmatodendrosis in the cerebral cortex of methamphetamine abusers.

Forensic Sci Res 2017 31;2(3):139-144. Epub 2017 Jan 31.

Department of Forensic Pathology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.

Postmortem investigation of methamphetamine (MA) abuse is an important task in forensic pathology. The present study investigated morphological changes in the astrocytes in the parietal cerebral cortex of MA abusers. Glial fibrillary acidic protein immunoreactivity in the cerebral cortex was examined in forensic autopsy cases for MA-detected group and control group. Read More

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January 2017

Microscopic examination of pituitary glands in cases of fatal accidental hypothermia.

Forensic Sci Res 2017 7;2(3):132-138. Epub 2017 Jun 7.

Institute of Forensic Medicine, University of Bonn, Bonn, Germany.

In cases of death caused by hypothermia, histological analysis can be used to determine the cause of death. Certain histological alterations of the pituitary glands in hypothermia have been reported in the literature, including haemorrhage, hyperaemia and cellular vacuolization of cells in the anterior lobe. In the present study, the validity of these morphological alterations as markers for fatal accidental hypothermia was investigated in autopsy material. Read More

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Brugada syndrome: a fatal disease with complex genetic etiologies - still a long way to go.

Forensic Sci Res 2017 5;2(3):115-125. Epub 2017 Jul 5.

Department of Forensic Pathology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.

Brugada syndrome (BrS) is an arrhythmogenic disorder which was first described in 1992. This disease is a channelopathy characterized by ST-segment elevations in the right precordial leads and is susceptible to sudden death. BrS is a fatal disease with gender and age preferences. Read More

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Diagnosis of coronary artery disease using targeted post-mortem computed tomography coronary angiography: a case report.

Forensic Sci Res 2017 5;2(2):107-111. Epub 2017 Jun 5.

Shanghai Key Laboratory of Forensic Science, Shanghai Forensic Service Platform, Department of Forensic Pathology, Institute of Forensic Science, Ministry of Justice, Shanghai, China.

Targeted post-mortem computed tomography (PMCT) combined with coronary angiography has the potential to play a significant role in the investigation of sudden cardiac death. The authors utilized a targeted PMCT coronary angiography in a case involving a 53-year-old man who died from acute myocardial ischemia and cardiac decompensation which may result from coronary artery disease (CAD). The victim collapsed suddenly at work and died soon after arrival to hospital. Read More

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June 2017
1 Read

A fatal case of oxygen embolism in a hospital.

Forensic Sci Res 2017 31;2(2):100-106. Epub 2017 May 31.

Unit of Forensic Imaging and Anthropology, University Center of Legal Medicine, CHUV Hospital, Lausanne-Geneva, Switzerland.

This case reports on a 68-year-old man who was found dead in hospital next to his bed. Before this, he had been treated with intravenous antibiotics for pneumonia. The body was found with a peripheral venous catheter connected to a nasal cannula delivering oxygen (O) from the wall. Read More

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State of the art in post-mortem forensic imaging in China.

Authors:
Yijiu Chen

Forensic Sci Res 2017 19;2(2):75-84. Epub 2017 Jun 19.

Institute of Forensic Science, Ministry of Justice, PRC, Shanghai, China.

The autopsy and histopathologic examination are traditional and classic approaches in forensic pathology. In recent years, with the tremendous progresses of computer technology and medical imaging technology, the developed post-mortem computer tomography, post-mortem magnetic resonance imaging and other new methods provide non-invasive, intuitive, high-precision examining methods and research tools for the forensic pathology. As a result, the reconstruction of the injury as well as the analysis of injury mechanism has been essentially achieved. Read More

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Intramedullary schwannoma of the upper cervical spinal cord: a case study of identification in pathologic autopsy.

Forensic Sci Res 2017 25;2(1):46-49. Epub 2017 Jan 25.

Medicolegal Department, Shantou University Medical College, Shantou, China.

Intramedullary schwannoma of the upper cervical spinal cord is rarely reported in forensic medicine. We herein report a case involving a patient who died of compression from an intramedullary schwannoma in the upper cervical spinal cord. A 30-year-old man initially presented with a five-day history of pain in the left chest that progressed to weakening in the left arm. Read More

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January 2017
1 Read

Systemic air embolism complicating upper gastrointestinal endoscopy: a case report with post-mortem CT scan findings and review of literature.

Forensic Sci Res 2016 16;1(1):52-57. Epub 2017 Jan 16.

Office of the Chief Medical Examiner, State of Maryland, Baltimore, MD, USA.

Endoscopy of the gastrointestinal and biliary tract is a common procedure and is routinely performed for therapeutic and diagnostic purposes. Perforation, bleeding and infection are some of the more common reported side effects. Air embolism on the other hand, is a rare complication of gastrointestinal endoscopy. Read More

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January 2017
2 Reads

Fatal poisoning involving cyclopropylfentanyl - Investigation of time-dependent postmortem redistribution.

Forensic Sci Int 2018 Nov 16;294:80-85. Epub 2018 Nov 16.

Department of Forensic Pharmacology and Toxicology, Zurich Institute of Forensic Medicine, University of Zurich, Switzerland. Electronic address:

A growing number of fatal overdoses involving opioid drugs, in particular involving fentanyl and its analogues, pose an immense threat to public health. Postmortem casework of forensic toxicologists in such cases is challenging, as data on pharmacodynamic and pharmacokinetic properties as well as reference values for acute toxicities and data on potential postmortem redistribution (PMR) mechanisms often do not exist. A fatal case involving cyclopropylfentanyl was investigated at the Zurich Institute of Forensic Medicine and the Zurich Forensic Science Institute; an unknown powder found at the scene was reliably identified as cyclopropylfentanyl by gas chromatography-infrared spectroscopy (GC-IR). Read More

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November 2018

"Contribution of the clinical information to the accuracy of the minimally invasive and the complete diagnostic autopsy".

Hum Pathol 2018 Nov 26. Epub 2018 Nov 26.

Department of Pathology, Maputo, Central Hospital, 1100 Maputo, Mozambique; Faculty of Medicine, Eduardo Mondlane University, 1100 Maputo, Mozambique.

Although autopsy diagnosis includes routinely, a thorough evaluation of all available pathological results and also of any available clinical data, the contribution of this clinical information to the diagnostic yield of the autopsy has not been analyzed. We aimed to determine to which degree the use of clinical data improves the diagnostic accuracy of the complete diagnostic autopsy (CDA) and the minimally invasive autopsy (MIA), a simplified pathological postmortem procedure designed for low-income sites. 264 coupled MIA and CDA procedures (112 adults, 57 maternal deaths, 54 children and 41 neonates) were performed at the Maputo hospital, Mozambique. Read More

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November 2018
1 Read
2.769 Impact Factor

Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017.

Authors:

Lancet 2018 Nov 8;392(10159):1736-1788. Epub 2018 Nov 8.

Background: Global development goals increasingly rely on country-specific estimates for benchmarking a nation's progress. To meet this need, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 estimated global, regional, national, and, for selected locations, subnational cause-specific mortality beginning in the year 1980. Here we report an update to that study, making use of newly available data and improved methods. Read More

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November 2018
3 Reads
45.220 Impact Factor

Embolization of Endocardial Vegetation With Stroke Presentation.

Am J Forensic Med Pathol 2018 Nov 27. Epub 2018 Nov 27.

Department of Biomedical Sciences, University of South Carolina School of Medicine Greenville, Greenville, SC.

This case report details the unique cause of death of a 37-year-old Caucasian woman with a history significant for intravenous drug abuse. Before her death, she complained of extremity weakness and pain. Although her death was discovered to be the result of endocarditis, her symptoms were similar to that of a stroke. Read More

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November 2018
3 Reads

Fatal ruptured ectopic pregnancy - a case report.

Med Leg J 2018 Nov 29:25817218795337. Epub 2018 Nov 29.

Department of Forensic Medicine, M.S. Ramaiah Medical College, Bangalore, India.

A 26-year-old unmarried female with a history of acute abdominal pain and bleeding per vagina was brought unresponsive to the hospital. She was in shock on arrival and could not be resuscitated. Death was registered as a medico-legal case. Read More

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November 2018
1 Read