92,104 results match your criteria Autopsy & case reports[Journal]


Fatal complication of sickle cell anemia in an immigrant patient rescued from the mediterranean sea.

Clin Ter 2020 Jul-Aug;171(4):e291-e294

Department Pro.Mi.Se., University of Palermo.

The aim of this case report is to share with the forensic science community the experience of a rare complication of sickle cell anemia: acute chest syndrome. In October 2016, at the port of the city of Trapani (Sicily, Italy), the landing of an ONG "Médecins Sans Frontières" ship took place with 548 non-EU citizens and a corpse on board. The man, in the hours before his death, complained of severe chest pain and respiratory difficulties, and, despite of the therapeutic aids and resuscitation maneuvers, lastly died. Read More

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http://dx.doi.org/10.7417/CT.2020.2230DOI Listing

SARS-CoV-2-related deaths in routine forensic autopsy practice: histopathological patterns.

Int J Legal Med 2020 Jun 29. Epub 2020 Jun 29.

UOC Medicina Legale ASUR AV3, Via Annibali 31L Piediripa, 62100, Macerata, Italy.

"Severe acute respiratory syndrome" (SARS) due to coronavirus (SARS-CoV-2) infection is a well-known cause of death. Sometimes, demise can occur unexpectedly in apparently previous healthy individual after a brief period of trivial flu-like symptoms. In these doubtful cases, the forensic pathologist could be requested to define the cause of death occurred outside the hospital. Read More

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http://dx.doi.org/10.1007/s00414-020-02354-5DOI Listing

Post-mortem histopathology of a pediatric brain after bilateral DBS of GPI for status dystonicus: case report and review of the literature.

Childs Nerv Syst 2020 Jul 2. Epub 2020 Jul 2.

Pediatric Anesthesiology and Intensive Care Unit, Children's Hospital A. Meyer-University of Florence, Florence, Italy.

Purpose: To investigate the effects of deep brain stimulation (DBS) electrodes on the brain of a dystonic pediatric patient submitted to bilateral DBS of the globus pallidus internus (GPI).

Methods: An 8-year-old male patient underwent bilateral DBS of GPI for status dystonicus. He died 2 months later due to multiorgan failure triggered by bacterial pneumonia. Read More

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http://dx.doi.org/10.1007/s00381-020-04761-wDOI Listing

[The key points to comprehend the pelvic fascia].

Authors:
H L Liu M B Lin

Zhonghua Wai Ke Za Zhi 2020 Jul;58(7):545-550

Department of General Surgery, Center for Translational Medicine, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, China.

Pelvic fascia is considered to be one controversial human anatomic structure. According to the characteristics of specialized surgery, colorectal surgeons, gynecologic surgeons and urologic surgeons respectively marked the pelvic fascia, but the naming is not unified. For some specific anatomic structures (such as pelvic plexus), different scholars have different descriptions of their positions. Read More

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http://dx.doi.org/10.3760/cma.j.cn112139-20191224-00636DOI Listing

[Foetus congenital cytomegalovirus infection: report of an autopsy case].

Zhonghua Bing Li Xue Za Zhi 2020 Jul;49(7):748-750

Department of Pathology, Guangdong Second Provincial General Hospital & Guangdong Provincial Emergency Hospital, Guangzhou 510317, China.

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http://dx.doi.org/10.3760/cma.j.cn112151-20200214-00100DOI Listing

[Sudden death in the young: the importance of autopsy and DNA testing].

Ned Tijdschr Geneeskd 2020 May 20;164. Epub 2020 May 20.

UMC Utrecht, afd. Cardiologie, Utrecht.

When a young person suddenly dies, there is a real chance that this was caused by genetic heart disease. Autopsy plays an important role in determining the cause of death, but the autopsy rate in the Netherlands is relatively low. Practical problems and a lack of information on autopsy play a role. Read More

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Application of scanning electron microscopy in the auxiliary diagnosis of death caused by potassium chloride intravenous injection: a case report.

Int J Legal Med 2020 Jun 30. Epub 2020 Jun 30.

Department of Forensic Medicine, Faculty of Basic Medical Sciences, Chongqing Medical University, Chongqing, 400016, China.

To determine the cause of death, in addition to routine autopsy, some assisted techniques are imperative to achieve a definite diagnosis. Herein, we report a case of 36-year-old man who was found dead in his apartment. Medical drug containers (potassium chloride, zolpidem, and propofol) and medical instruments (syringes and indwelling needles) were also found at the scene. Read More

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http://dx.doi.org/10.1007/s00414-020-02361-6DOI Listing

The adulterated XANAX pill: a fatal intoxication with etizolam and caffeine.

Int J Legal Med 2020 Jun 30. Epub 2020 Jun 30.

Institute of Legal Medicine, University Medical Center, St.-Georg-Strasse 108, 18055, Rostock, Germany.

A 49-year old man was found dead at home next to a glass containing a dried, white, crystalline substance and near a bag containing pills with the imprint XANAX, the trade name of alprazolam. A comprehensive screening of material collected during the autopsy revealed the presence of etizolam and caffeine in lethal concentrations (0.77 μg/mL and 190 μg/mL) but no trace of alprazolam. Read More

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http://dx.doi.org/10.1007/s00414-020-02352-7DOI Listing

The evolution of pulmonary pathology in fatal COVID-19 disease: an autopsy study with clinical correlation.

Virchows Arch 2020 Jun 30. Epub 2020 Jun 30.

Department of Pathology and Neuropathology, University Hospital Tübingen and Eberhard Karls University Tübingen, Liebermeisterstraße 8, 72076, Tübingen, Germany.

The pandemia of coronavirus disease 2019 (COVID-19) has caused more than 355,000 confirmed deaths worldwide. However, publications on postmortem findings are scarce. We present the pulmonary findings in four cases of fatal COVID-19 with a spectrum of lung pathology reflecting disease course and duration, invasive therapies, and laboratory features. Read More

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http://dx.doi.org/10.1007/s00428-020-02881-xDOI Listing

Axonal degeneration in Guillain-Barré syndrome: a reappraisal.

Authors:
José Berciano

J Neurol 2020 Jun 30. Epub 2020 Jun 30.

Professor Emeritus of Neurology, Service of Neurology, University Hospital "Marqués de Valdecilla (IDIVAL)", "Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED)", University of Cantabria, Santander, Spain.

The aim of this review was to analyse the pathophysiology of axonal degeneration in Guillain-Barré syndrome (GBS) with emphasis on early stages (≤ 10 days after onset). An overview of experimental autoimmune neuritis (EAN) models is provided. Originally GBS and acute inflammatory demyelinating polyneuropathy were equated, presence of axonal degeneration being attributed to a "bystander" effect. Read More

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http://dx.doi.org/10.1007/s00415-020-10034-yDOI Listing

COVID-19 autopsy in people who died in community settings: the first series.

J Clin Pathol 2020 Jun 30. Epub 2020 Jun 30.

Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK

Here, we report the pathological findings of nine complete autopsies of individuals who died in community settings in the UK, three of which were positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), three tested negative for SARS-CoV-2 but are likely false negatives, and three died of other respiratory infections. Autopsy revealed firm, consolidated lungs or lobar pneumonia. Histology of the lungs showed changes of diffuse alveolar damage with fibrin membrane formation, thickened alveolar walls and interstitium with lymphocytic infiltrate, and type 2 pneumocyte hyperplasia with shedding into the alveolar space. Read More

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http://dx.doi.org/10.1136/jclinpath-2020-206710DOI Listing

Community memory screening as a strategy for recruiting older adults into Alzheimer's disease research.

Alzheimers Res Ther 2020 Jun 30;12(1):78. Epub 2020 Jun 30.

Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0948, USA.

Background: Growing awareness of Alzheimer's disease (AD) has prompted a demand for quick and effective ways to screen for memory loss and cognitive decline in large numbers of individuals in the community. Periodic Memory Screening Day events provide free, brief cognitive screening aimed at those 65 years and older, and can serve as an opportunity to gauge participants' attitudes towards AD research and recruit them into ongoing research projects.

Methods: Over 6 single-day events in 2 years, more than 574 individuals were individually screened using the MoCA and a story recall task (immediate and delayed), given feedback about their performance, and introduced to AD research and opportunities to participate. Read More

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http://dx.doi.org/10.1186/s13195-020-00643-0DOI Listing

Clinical-Forensic Autopsy Findings to Defeat COVID-19 Disease: A Literature Review.

J Clin Med 2020 Jun 28;9(7). Epub 2020 Jun 28.

Department of Medical, Surgical and Advanced Technologies "G.F. Ingrassia", University of Catania, 95121 Catania, Italy.

The severe acute respiratory syndrome (SARS)-CoV-2 was identified for the first time in China, in December 2019. Confirmed cases of COVID-19 have been reported around the world; indeed, this infection has been declared a pandemic. Consequently, the scientific community is working hard to gain useful information about the history of this virus, its transmission, diagnosis, clinical features, radiological findings, research and development of candidate therapeutics as well as vaccines. Read More

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http://dx.doi.org/10.3390/jcm9072026DOI Listing

Asphyxia Homicides in Finland, 1983-2012.

J Forensic Sci 2020 Jun 30. Epub 2020 Jun 30.

Department of Community Medicine and Rehabilitation/Forensic Medicine, Umeå University, Umeå, Sweden.

Finland has one of the highest homicide rates in Western Europe, and almost every tenth homicide is caused by asphyxiation. Reliable statistics, a strict legislation, and an exceptionally high medico-legal autopsy rate formed a base for a nationwide analysis of asphyxia homicides (n = 383) during 30 years. The cases were identified through multiple records, and all the forensic pathology case files were studied in detail. Read More

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http://dx.doi.org/10.1111/1556-4029.14458DOI Listing

The Application of Photogrammetry in the Autopsy Room: A Basic, Practical Workflow.

J Forensic Sci 2020 Jun 30. Epub 2020 Jun 30.

Department of Pathology, State University of New York, Upstate Medical University, 750 E Adams St, Syracuse, NY, 13202.

Photogrammetry is a technique that uses two-dimensional photographs taken from different angles and positions to determine three-dimensional coordinates and distances. Becoming familiar with the photography technique for photogrammetry purposes is the first step to obtaining high-quality results. Ten human cadavers were studied to develop this protocol. Read More

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http://dx.doi.org/10.1111/1556-4029.14493DOI Listing

Endocrine and Metabolic Manifestations of Snakebite Envenoming.

Am J Trop Med Hyg 2020 Jun 29. Epub 2020 Jun 29.

Department of Endocrinology, Manipal Hospital, New Delhi, India.

Snake envenoming is a neglected, public health problem in tropical and subtropical regions. Local tissue necrosis, neurotoxic, and hemo-vasculotoxic effects are well-recognized features, whereas the endocrine and metabolic derangements are not as well known. In addition to contributing to morbidity, some of these manifestations can be potentially life-threatening if not recognized early. Read More

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http://dx.doi.org/10.4269/ajtmh.20-0161DOI Listing

Three-Dimensional Microstructural Basis for Differential Occurrence of Subcapital versus Basicervical Hip Fractures in Men.

Calcif Tissue Int 2020 Jun 29. Epub 2020 Jun 29.

Laboratory for Anthropology and Skeletal Biology, Institute of Anatomy, Faculty of Medicine, University of Belgrade, Dr Subotica 4/2, Belgrade, 11000, Serbia.

We analyzed the bone microarchitecture of the subcapital and basicervical subregions of the femoral neck in men, to determine whether microarchitectural differences of cortical or trabecular bone can explain differential frequency of subcapital vs. basicervical fractures, especially in aged persons. The study sample encompassed twenty male proximal femora obtained during autopsy. Read More

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http://dx.doi.org/10.1007/s00223-020-00717-zDOI Listing

Brain tight junction protein expression in sepsis in an autopsy series.

Crit Care 2020 Jun 29;24(1):385. Epub 2020 Jun 29.

Division of Intensive Care Medicine, Department of Anesthesiology, Research Group of Surgery, Anesthesiology and Intensive Care Medicine, Oulu University Hospital, Medical Research Center Oulu, University of Oulu, Oulu, Finland.

Background: Neuroinflammation often develops in sepsis along with increasing permeability of the blood-brain barrier (BBB), which leads to septic encephalopathy. The barrier is formed by tight junction structures between the cerebral endothelial cells. We investigated the expression of tight junction proteins related to endothelial permeability in brain autopsy specimens in critically ill patients deceased with sepsis and analyzed the relationship of BBB damage with measures of systemic inflammation and systemic organ dysfunction. Read More

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http://dx.doi.org/10.1186/s13054-020-03101-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325252PMC

Genotype-phenotype correlation in two Polish neonates with alveolar capillary dysplasia.

BMC Pediatr 2020 Jun 29;20(1):320. Epub 2020 Jun 29.

Department of Neonatology, Neonatal Biophysical Monitoring and Cardiopulmonary Therapies Research Unit, Poznan University of Medical Sciences, Poznan, Poland.

Background: Alveolar capillary dysplasia (ACD) is a rare cause of severe pulmonary hypertension and respiratory failure in neonates. The onset of ACD is usually preceded by a short asymptomatic period. The condition is refractory to all available therapies as it irreversibly affects development of the capillary bed in the lungs. Read More

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http://dx.doi.org/10.1186/s12887-020-02200-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322906PMC

Effect of Maternal Rubella Virus Infection on Fetal Cardiac Function and Neural Development by Color Doppler Ultrasound (Cardiography) Information Technology.

Authors:
Haixia Liu Wei Shi

Neurosci Lett 2020 Jun 26:135209. Epub 2020 Jun 26.

Third department of Ultrasound, Cangzhou Central Hospital, Cangzhou City, 061001, Hebei Province, China. Electronic address:

This study was aimed to explore the effect of maternal rubella virus infection on fetal cardiac function and neural development by color Doppler ultrasound cardiogram based on computer information technology. 658 pregnant women who were treated in our hospital were selected as the research subject. The rubella virus IgM antibody test, prenatal color Doppler ultrasound cardiogram test, suspicious neonatal ultrasound test and follow-up were performed on them. Read More

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http://dx.doi.org/10.1016/j.neulet.2020.135209DOI Listing

[Etiology of severe community - acquired pneumonia in adults: results of the first Russian multicenter study].

Ter Arkh 2020 Jan 15;92(1):36-42. Epub 2020 Jan 15.

M.K. Ammosov Federal North-Eastern University.

Aim: to study the etiology of severe community - acquired pneumonia (SCAP) in adults in Russian Federation. SCAP is distinguished by high mortality and socio - economic burden. Both etiology and antimicrobial resistance are essential for appropriate antibiotic choice. Read More

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http://dx.doi.org/10.26442/00403660.2020.01.000491DOI Listing
January 2020

[Cardiovascular syphilis (current state of the problem and analysis of own observations)].

Ter Arkh 2019 Nov 15;91(11):81-85. Epub 2019 Nov 15.

Novosibirsk State Medical University.

A description of two cases of cardiovascular syphilis is presented. The introduction discusses the relevance of visceral syphilis. The literary review is constructed in a chronological format and reflects the stages of studying the problem of cardiovascular syphilis. Read More

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http://dx.doi.org/10.26442/00403660.2019.11.000246DOI Listing
November 2019

Incidental detection of unexpected neck lymphatic III level node metastasis from occult papillary thyroid carcinoma during cervical disc surgery: first literature report.

Endokrynol Pol 2020 Jun 29. Epub 2020 Jun 29.

Pathology Department, District Hospital, Arkonska 4, 71-455 Szczecin, Poland.

Background: The regional lymph node metastases of papillary thyroid carcinoma are very common. Subclinical neck lymphatic malignancy of the undiagnosed papillary carcinoma can be found by chance at autopsy or intravitally, especially during neck imaging scrutiny for other reasons. And cervical lymph node metastasis as the initial manifestation of occult papillary thyroid carcinoma is very rare phenomenon. Read More

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http://dx.doi.org/10.5603/EP.a2020.0031DOI Listing

Preserving Access to the Invaluable Clinical Autopsy.

JAMA Intern Med 2020 Jun 29. Epub 2020 Jun 29.

Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, University of California, San Francisco.

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http://dx.doi.org/10.1001/jamainternmed.2020.2236DOI Listing

Assessment of Racial Differences in Rates of Autopsy in the US, 2008-2017.

JAMA Intern Med 2020 Jun 29. Epub 2020 Jun 29.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1001/jamainternmed.2020.2239DOI Listing

Clinical and Pathological Phenotypes of LRP10 Variant Carriers with Dementia.

J Alzheimers Dis 2020 Jun 22. Epub 2020 Jun 22.

Erasmus MC, University Medical Center Rotterdam, Department of Clinical Genetics, Rotterdam, the Netherlands.

Background: Rare variants in the low-density lipoprotein receptor related protein 10 gene (LRP10) have recently been implicated in the etiology of Parkinson's disease (PD) and dementia with Lewy bodies (DLB).

Objective: We searched for LRP10 variants in a new series of brain donors with dementia and Lewy pathology (LP) at autopsy, or dementia and parkinsonism without LP but with various other neurodegenerative pathologies.

Methods: Sanger sequencing of LRP10 was performed in 233 donors collected by the Netherlands Brain Bank. Read More

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http://dx.doi.org/10.3233/JAD-200318DOI Listing

[Methodological basis for determining a person's age].

Sud Med Ekspert 2020 ;63(3):45-50

Medicine of Sechenov First Moscow State Medical University under Ministry of Health of the Russian Federation, Moscow, Russia.

This paper presents a review of modern fundamental research studies investigating the age-related changes of connective, cartilage, nervous and bone tissues. A methodological and mathematical basis for the analysis of the obtained results is proposed. The conducted analysis enabled the formulation of a new scientific direction - the forensic medical determination of age in the identification of individuals in emergency situations with mass casualties. Read More

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http://dx.doi.org/10.17116/sudmed20206303145DOI Listing
January 2020

[Pathomorphological features of baby shaking syndrome].

Sud Med Ekspert 2020 ;63(3):19-22

Chuvash State University named after I.N. Ulyanov, Cheboksary, Russia.

The aim of study is to identify pathomorphological changes of the Central nervous system in childhood with rarely diagnosed of «baby shaking» syndrome on the example of sectional case. The analysis of medical documentation (medical history and outpatient card of the child) was done. The standard method of opening the skull cavity of infants was used. Read More

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http://dx.doi.org/10.17116/sudmed20206303119DOI Listing
January 2020

[Renomedullary interstitial cell tumor: review of a rare clinical case].

Urologiia 2020 Jun(3):91-93

Morphological Department of the Clinic of Rostov State Medical University, Rostov-on-Don, Russia.

Autopsy study of a 49-year-old patient demonstrates a rare kidney tumor that had a structure of a mesenchymal renomedullary interstitial tumor (RIO), which had specific characteristics. They include a predominance of the cellular component in the tumor, represented by cells with processes elements (fibroblasts, myofibroblasts), which were surrounded by collagen fibers of interstitium. Apparently, these cells can be involved in the regulation of renin and bicarbonates, the exchange of components of connective tissue (collagen fibers, proteoglycans) and hormones (estrogen, progesterone). Read More

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Prenatal over- and undernutrition differentially program small intestinal growth, angiogenesis, absorptive capacity, and endocrine function in sheep.

Physiol Rep 2020 Jun;8(12):e14498

Department of Animal Science, Faculty of Technical Sciences, Aarhus University, Tjele, Denmark.

The aim was to test the hypothesis that prenatal under- and overnutrition in late gestation can program small intestinal (SI) growth, angiogenesis, and endocrine function to predispose for a hyperabsorptive state, thereby increasing the susceptibility to the adverse effects of an early postnatal obesogenic diet. Twin-pregnant ewes were exposed to adequate (NORM), LOW (50% of NORM), or HIGH (150% energy and 110% protein of NORM) diets through the last trimester (term ~147 days). From 3 days to 6 months of age, their lambs were fed either a moderate (CONV) or a high-carbohydrate high-fat (HCHF) diet. Read More

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http://dx.doi.org/10.14814/phy2.14498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322502PMC

Downregulation of MHC Class I Molecules by HCMV Occurs During All Phases of Viral Replication but Is Not Always Complete.

Front Cell Infect Microbiol 2020 12;10:283. Epub 2020 Jun 12.

Institute of Virology, Ulm University Medical Center, Ulm, Germany.

Based on cell culture data, MHC class I downregulation by HCMV on infected cells has been suggested as a means of immune evasion by this virus. In order to address this issue , an immunohistochemical analysis of tissue sections from biopsy and autopsy materials of HCMV infected organs was performed. HCMV antigens from the immediate early, early, and late phase of viral replication, and cellular MHC class I molecules were detected simultaneously or in serial sections by immuno-peroxidase and immuno-alkaline phosphatase techniques. Read More

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http://dx.doi.org/10.3389/fcimb.2020.00283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304332PMC

First Report of spp. Infection in Eurasian Lynx and Its Histopathology Study from Iran: A Case Report.

Iran J Parasitol 2020 Apr-Jun;15(2):282-286

Young Researchers and Elite Club, Babol Branch, Islamic Azad University, Babol, Iran.

According to the last information of IUCN Red List, Eurasian lynx has been endangered since 2010. The population of this animal is heavily affected by infectious parasites. Two adult Eurasian lynx (one male and one female) were illegally hunted and found dead in Parvar National Park, Semnan Province, Iran. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311823PMC

Tumor lysis syndrome in a patient with metastatic melanoma treated with nivolumab.

Clin J Gastroenterol 2020 Jun 27. Epub 2020 Jun 27.

Department of Gastroenterology, Kanazawa University Hospital, 13-1 Takara-Machi, Kanazawa, Ishikawa, 920-8641, Japan.

A 79-year-old man with metastatic melanoma of the right maxillary sinus and multiple liver metastases received a single dose of nivolumab. Eight days later, he experienced impaired consciousness, accompanied by abnormal laboratory and electrocardiographic findings. He was therefore diagnosed with tumor lysis syndrome (TLS). Read More

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http://dx.doi.org/10.1007/s12328-020-01164-xDOI Listing

[Comparative evaluation of ultrasonic virtopsia and classical autopsy for antenatal fetal death].

Arkh Patol 2020 ;82(3):51-54

Forensic Medicine Bureau, St. Petersburg, Russia.

Aim Of Study: Comparison of the data obtained by ultrasound examination of a pregnant woman with antenatal death of the fetus and stillborn child, with the autopsy results.

Materials And Methods: The protocols of ultrasound examinations and the autopsy protocols of 126 fetuses that died antenatally were analyzed.

Results: In our study of 126 patients, 95 showed no structural changes either during ultrasound examination or during further pathomorphological examination. Read More

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http://dx.doi.org/10.17116/patol20208203151DOI Listing
January 2020

Somatosensory area 3b is selectively unaffected in corticobasal syndrome: combining MRI and histology.

Neurobiol Aging 2020 May 21;94:89-100. Epub 2020 May 21.

Institute for Anatomy I, Medical Faculty, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany; Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany; JARA-BRAIN, Jülich-Aachen Research Alliance, Research Centre Jülich, Jülich, Germany. Electronic address:

An increasing number of neuroimaging studies addressing patients with corticobasal syndrome use macroscopic definitions of brain regions. As a closer link to functionally relevant units, we aimed at identifying magnetic resonance-based atrophy patterns in regions defined by probability maps of cortical microstructure. For this purpose, three analyses were conducted: (1) Whole-brain cortical thickness was compared between 36 patients with corticobasal syndrome and 24 controls. Read More

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http://dx.doi.org/10.1016/j.neurobiolaging.2020.05.009DOI Listing

Direct maternal deaths attributable to HIV in the era of antiretroviral therapy: evidence from three population-based HIV cohorts with verbal autopsy.

AIDS 2020 Jul;34(9):1397-1405

Department of Population Health, London School of Hygiene & Tropical Medicine, London, UK.

Objective: To assess whether HIV is associated with an increased risk of mortality from direct maternal complications.

Design: Population-based cohort study using data from three demographic surveillance sites in Eastern and Southern Africa.

Methods: We use verbal autopsy data, with cause of death assigned using the InSilicoVA algorithm, to describe the association between HIV and direct maternal deaths amongst women aged 20-49 years. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002552DOI Listing

Postmortem swabs in the Sars-CoV-2 Pandemic: Report on 12 complete clinical autopsy cases.

Arch Pathol Lab Med 2020 Jun 26. Epub 2020 Jun 26.

Department of Woman and Child Health and Public Health, Area of Pathology, Catholic University of Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, U.O.S.D. Coordinamento attività di Settorato; Rome, Italy (Dr. Dell'Aquila, Mr. Stigliano, Dr. Carbone, Dr. Arena); Department of Basic Biotechnological Sciences, Intensivological and Perioperative Clinics, Fondazione Policlinico A. Gemelli IRCCS, Catholic University of Sacred Heart, Rome, Italy (Dr. Cattani); Department of laboratory and infectivological sciences, Fondazione Policlinico A. Gemelli IRCCS, Catholic University of Sacred Heart, Rome, Italy (Dr. Fantoni); Department of Safety and Bioethics, Section of Infectious Diseases, Catholic University of Sacred Heart; Columbus Covid 2 Hospital, Fondazione Policlinico A Gemelli IRCCS, Roma, Italy Università Cattolica S. Cuore, (Dr. Marchetti); Institute of Legal Medicine and Department of Surgical and Medical Sciences at the University "Magna Graecia" of Catanzaro, Italy (Dr. Aquila); Department of Safety and Bioethics, Section of Legal Medicine, Fondazione Policlinico A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy (Dr. Oliva).

Clinical autopsies have historically provided a fundamental contribution in the definition of the clinico-pathological basis of infectious diseases. Even though we are witnessing the decline of the clinical autopsy, its importance remains unchanged as it is the most exhaustive way to investigate diseases. The identification of the virus in postmortem tissues is a fundamental step in the definition of its clinical features. Read More

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http://dx.doi.org/10.5858/arpa.2020-0362-SADOI Listing
June 2020
2.838 Impact Factor

Fatal course of clofazimine-induced pulmonary crystal deposition in a patient with Melkersson-Rosenthal syndrome
.

Int J Clin Pharmacol Ther 2020 Jun 26. Epub 2020 Jun 26.

A wide variety of drugs and substances have the potential to damage the respiratory system by different mechanisms. Clofazimine is an anti-leprosy drug that is normally only prescribed for a few years. It has a very long half-life, and crystalline deposition of the drug in various tissues has been documented. Read More

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http://dx.doi.org/10.5414/CP203784DOI Listing

Central nervous system pathology in the amniotic rupture sequence.

Authors:
Patrick Shannon

Clin Neuropathol 2020 Jun 26. Epub 2020 Jun 26.

Aims: We delineate and review the central nervous system (CNS) pathology of amniotic rupture sequence (ARS) and its extraneural associations.

Materials And Methods: We review a consecutive 15-year fetal/neonatal autopsy series for cases of ARS to document its morphology and correlates.

Results: We retrieved 15 cases of ARS with complete dissection of the CNS. Read More

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http://dx.doi.org/10.5414/NP301266DOI Listing

Basophilic invasion in the neurohypophysis is increased in patients with Alzheimer's disease.

Clin Neuropathol 2020 Jun 26. Epub 2020 Jun 26.

Purpose: The prevalence of basophilic invasion (BI) and degenerative changes in the neurohypophysis of humans with neurodegenerative disease is not established.

Materials And Methods: We evaluated 122 pituitary glands reviewed at autopsy including 45 with Alzheimer's disease (AD) Braak and Braak stage V or VI, 18 with Lewy body disease (LBD), and 59 age-matched controls for BI. In addition, pituitary glands from 51 patients including 25 patients with AD and 18 aged-matched controls were studied with a periodic acid Schiff (PAS) stain and immunohistochemistry with a polyclonal antibody to nestin. Read More

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http://dx.doi.org/10.5414/NP301255DOI Listing

[CUP in the liver].

Pathologe 2020 Jun 25. Epub 2020 Jun 25.

Institut für Pathologie,an den Universitätskliniken Bergmannsheil, Ruhr-Universität Bochum, Bürkle de la Camp-Platz 1, 44789, Bochum, Deutschland.

Hepatic involvement is one of the most common manifestations in cancer of unknown primary (CUP) syndrome. The most frequent secondary neoplasms of the liver are carcinomas and malignant melanomas. Most common carcinoma metastases are adenocarcinomas originating from the digestive system or metastases of breast and lung carcinomas. Read More

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http://dx.doi.org/10.1007/s00292-020-00803-xDOI Listing

How to deal with the suffering: Utility of an emotional containment strategy to collect data for verbal autopsies in Mexico.

Death Stud 2020 Jun 25:1-6. Epub 2020 Jun 25.

Institute for Health Metrics and Evaluation, University of Washington, Seattle, Washington, USA.

Verbal autopsies are often used to establish cause of death but can be emotionally taxing on the interviewers. We conducted focus groups with interviewers ( = 15) who collected data for verbal autopsies in Mexico in order to explore the utility of an emotional containment strategy designed to boost self-confidence and resilience. The interviewers reflected on broader cultural perspectives on illness and death and described the strategy as helpful in developing strategies to manage emotionally stressful situations and develop their confidence in their work performance. Read More

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http://dx.doi.org/10.1080/07481187.2020.1784310DOI Listing

Monochorionic diamniotic twins of discordant external genitalia with 45,X/46,XY mosaicism.

Mol Genet Genomic Med 2020 Jun 25:e1382. Epub 2020 Jun 25.

Center for Maternal-Fetal-Neonatal and Reproductive Medicine, National Center for Child Health and Development, Setagaya-ku, Tokyo, Japan.

Background: Monozygotic twins with 45,X/46,XY mosaicism, discordant for phenotypic sex, are extremely rare.

Methods: This report describes the clinical findings of a rare case of 45,X/46,XY mosaicism in monozygotic twins with different external genitalia. Single nucleotide polymorphism (SNP) array analysis, performed by collecting DNA from each umbilical cord, showed identical SNPs in the autosomal chromosomes of both fetuses. Read More

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http://dx.doi.org/10.1002/mgg3.1382DOI Listing

How Are We Facing It? Dispatches From Pathology Residents in a COVID-19 Lombardy Hospital.

Front Public Health 2020 4;8:259. Epub 2020 Jun 4.

Department of Pathology, Humanitas Clinical and Research Center IRCCS, Milan, Italy.

At the end of February, the Italian National Health Service reported a hot spot of Coronavirus disease in the Lombardy region. COVID-19 is a highly pathogenic viral infection which poses some challenges for healthcare workers. Indeed, Pathology Departments are involved in reorganizing samples' management, from their delivery until their processing, according to National and WHO guidelines. Read More

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http://dx.doi.org/10.3389/fpubh.2020.00259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287170PMC

Is cell block technique useful to predict histological type in patients with ovarian mass and/or body cavity fluids?

Nagoya J Med Sci 2020 May;82(2):225-235

Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

The cell block (CB) technique is a generalized method utilized for the diagnostic evaluation of body cavity fluids. Ascites cytology is one of the most important diagnostic processes for epithelial ovarian cancer. However, in clinical practice, the usefulness of the CB method to diagnose this tumor remains unelucidated. Read More

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http://dx.doi.org/10.18999/nagjms.82.2.225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276405PMC

Morphoproteomics and Etiopathogenic Features of Pulmonary COVID-19 with Therapeutic Implications: A Case Study.

Ann Clin Lab Sci 2020 May;50(3):308-313

Department of Pathology and Laboratory Medicine, UTHealth McGovern Medical School, Texas, USA.

Objective: The COVID-19 pandemic has challenged the world economically and medically. Understanding and defining the biology of this specific coronavirus infection may lead to targeted therapies to lessen its virulence and expand the host resistance. This study's objective was to apply morphoproteomics to pulmonary lung sections from a forensic autopsy of an untreated COVID-19 victim, so that we may better define its biology from the perspective of its interaction with the host and provide options for therapeutic targets. Read More

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A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids.

Cell Stem Cell 2020 Jun 19. Epub 2020 Jun 19.

Department of Surgery, Weill Cornell Medicine, 1300 York Ave, New York, NY 10065, USA. Electronic address:

SARS-CoV-2 has caused the COVID-19 pandemic. There is an urgent need for physiological models to study SARS-CoV-2 infection using human disease-relevant cells. COVID-19 pathophysiology includes respiratory failure but involves other organ systems including gut, liver, heart, and pancreas. Read More

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http://dx.doi.org/10.1016/j.stem.2020.06.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303620PMC

Systemic inflammatory response and thrombosis due to alterations in the gut microbiota in COVID-19.

Rev Esp Enferm Dig 2020 Jun 24;112. Epub 2020 Jun 24.

Gastroenterology, Ameos Klinikum .

We thank Dr. Cienfuegos and colleagues for their comments on our recent publication "COVID-19, Coronavirus, SARS-CoV-2 and the small bowel". Cienfuegos et al. Read More

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http://dx.doi.org/10.17235/reed.2020.7297/2020DOI Listing