89,396 results match your criteria Autopsy & case reports[Journal]


Home deaths of children under 5 years in rural South Africa: a population-based longitudinal study.

Trop Med Int Health 2019 Apr 19. Epub 2019 Apr 19.

Nuffield Department of Primary Care Health Sciences, University of Oxford, UK.

Objectives: To determine the proportion of under-5 deaths that occurred at home in rural South Africa, whether care was sought prior to death, and determinants of home deaths amongst those who sought care.

Methods: Verbal autopsy data were used for all under-5 deaths, 2000-2015, in two health and demographic surveillance system sites. Trends in place of death and care-seeking were assessed. Read More

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http://dx.doi.org/10.1111/tmi.13239DOI Listing

Postmortem distribution of acephate and its metabolite methamidophos in body fluids and organ tissues of an intoxication case.

Forensic Sci Int 2019 Apr 4. Epub 2019 Apr 4.

Department of Forensic Medicine, Wakayama Medical University, Wakayama 641-8509, Japan.

We herein report an intoxication case caused by the ingestion of the pesticide Ortoran, which consists of 50% acephate aqueous solution. A man in his 60 s was found dead in his car with a 100-mL bottle containing approximately 50 mL of Ortoran. In a gas chromatography - mass spectrometry (GC-MS) screening test, acephate and its metabolite methamidophos were qualitatively detected in his stomach contents. Read More

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http://dx.doi.org/10.1016/j.forsciint.2019.02.015DOI Listing

Disseminated melanized fungal infection due to Cladosporium halotolerans in a dog coinfected with canine adenovirus-1 and canine parvovirus-2.

Braz J Microbiol 2019 Apr 17. Epub 2019 Apr 17.

Small Animal Internal Medicine, Department of Veterinary Clinics, Universidade Estadual de Londrina, Londrina, Paraná, Brazil.

This report presents the pathologic findings associated with disseminated infection due to Cladosporium halotolerans in a dog that was simultaneously infected with canine adenovirus-1 (CAdV-1) and canine parvovirus-2 (CPV-2). A 12-year-old, mixed breed dog, with a clinical history of neurological manifestations was submitted for routine autopsy due to poor prognosis. The principal pathologic findings were mycotic necrotizing nephritis, hepatitis, and splenitis with embolic dissemination to the brain resulting in mycotic necrotizing meningoencephalitis, ventriculitis, choroid plexitis, and obstructive hydrocephalus associated with intralesional and intravascular septate pigmented fungi. Read More

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http://dx.doi.org/10.1007/s42770-019-00082-6DOI Listing

A case of fatal acebutolol poisoning: an illustration of the potential of molecular networking.

Int J Legal Med 2019 Apr 17. Epub 2019 Apr 17.

INSERM, INRA, CHU Rennes, Institut NuMeCan (Nutrition, Metabolism and Cancer), University Rennes, 35000, Rennes, France.

Acebutolol is a β1-selective adrenergic receptor antagonist with moderate membrane-stabilizing activity and intrinsic sympathomimetic activity; accordingly, the drug is indicated in hypertension, angina pectoris, and arrhythmia. However, acebutolol's beta-blocking properties also extend the QRS and QTc intervals, and may predispose the patient to ventricular tachydysrhythmia. Here, we report autopsy and toxicological findings on a fatal case of acebutolol self-poisoning in a 70-year-old woman. Read More

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http://link.springer.com/10.1007/s00414-019-02062-9
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http://dx.doi.org/10.1007/s00414-019-02062-9DOI Listing
April 2019
2 Reads

A case of desmoplakin mutation and delayed arrhythmogenic right ventricular cardiomyopathy/dysplasia after atrial septal defect closure.

J Cardiol Cases 2019 Apr 6;19(4):111-114. Epub 2019 Feb 6.

Department of Cardiology, Tokyo Women's Medical University, Tokyo, Japan.

Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is a slow-developing cardiomyopathy characterized by ventricular arrhythmias and fibrofatty replacement of the right ventricular (RV) myocardium. Its clinical diagnosis is challenging because of its variable clinical presentation and low genetic penetrance. We describe the case of a 67-year-old man who was diagnosed as having ARVC/D with a desmoplakin mutation that appeared after occlusion of an atrial septal defect (ASD). Read More

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http://dx.doi.org/10.1016/j.jccase.2018.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451054PMC

A Long-term Survival after Surgical Treatment for Atypical Aortic Coarctation Complicating Takayasu Arteritis with Inactive Disease at the Diagnosis: An Appropriately Treated Autopsy Case.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Division of Rheumatology, Department of Internal Medicine, Kanazawa University Graduate School of Medicine, Japan.

The number of Takayasu arteritis (TAK) cases being diagnosed at an advanced age has increased, including some who develop ischemic lesions without inflammation of the involved arteries long after the onset of TAK. However, few histopathological analyses of such patients without immunosuppressive therapy have been reported. We herein report a 92-year-old woman with atypical aortic coarctation complicating TAK who underwent bypass graft surgery and survived for 23 years without immunosuppressive therapy. Read More

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http://dx.doi.org/10.2169/internalmedicine.2483-18DOI Listing
April 2019
1 Read

CT and gross pathology are comparable methods for detecting some degenerative sacroiliac joint lesions in dogs.

Vet Radiol Ultrasound 2019 Apr 16. Epub 2019 Apr 16.

Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, Virginia.

Degenerative sacroiliac joint disease is a cause of lumbosacral pain in dogs; however, published information on cross-sectional imaging characteristics is limited. Objectives of this retrospective, secondary analysis, methods-comparison study were to test hypotheses that CT lesions reported in humans with degenerative sacroiliac joint disease are also present in dogs, and that CT is comparable to gross pathology for detecting these lesions. Matched CT and gross pathology slice images of 30 sacroiliac joints were retrieved from a previous prospective, canine cadaver study. Read More

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http://dx.doi.org/10.1111/vru.12749DOI Listing
April 2019
1 Read

Misfolded SOD1 inclusions in patients with mutations in and other ALS/FTD-associated genes.

J Neurol Neurosurg Psychiatry 2019 Apr 16. Epub 2019 Apr 16.

Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden

Objective: A hallmark of amyotrophic lateral sclerosis (ALS) caused by mutations in () are inclusions containing SOD1 in motor neurons. Here, we searched for SOD1-positive inclusions in 29 patients carrying ALS-linked mutations in six other genes.

Methods: A panel of antibodies that specifically recognise misfolded SOD1 species were used for immunohistochemical investigations of autopsy tissue. Read More

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http://jnnp.bmj.com/lookup/doi/10.1136/jnnp-2018-319386
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http://dx.doi.org/10.1136/jnnp-2018-319386DOI Listing
April 2019
1 Read

All-cause, cause-specific and age-specific standardised mortality ratios of patients with systemic lupus erythematosus in Ontario, Canada over 43 years (1971-2013).

Ann Rheum Dis 2019 Apr 16. Epub 2019 Apr 16.

Center for Prognosis Studies in the Rheumatic Diseases, Toronto Lupus Clinic, University Health Network, University of Toronto, Toronto, Ontario, Canada

Background: Survival in systemic lupus erythematosus (SLE) has improved substantially in the last 50 years. The aim of the present study was to assess the evolution of the all-cause, cause-specific and age-specific standardised mortality ratios (SMRs) of patients with lupus in Ontario, Canada.

Patients And Methods: Between 1971 and 2013, 1732 patients were followed in the Toronto Lupus Clinic. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214802DOI Listing

Machine learning performance in a microbial molecular autopsy context: A cross-sectional postmortem human population study.

PLoS One 2019 15;14(4):e0213829. Epub 2019 Apr 15.

Texas A&M University, Department of Entomology, College Station, TX, United States of America.

Background: The postmortem microbiome can provide valuable information to a death investigation and to the human health of the once living. Microbiome sequencing produces, in general, large multi-dimensional datasets that can be difficult to analyze and interpret. Machine learning methods can be useful in overcoming this analytical challenge. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213829PLOS

Monoamine Oxidase B Binding of 18F-THK5351 to Visualize Glioblastoma and Associated Gliosis: An Autopsy-Confirmed Case.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

An 86-year-old woman with cognitive impairment and left hemiparesis underwent F-THK5351 PET 4 months before her death. In addition to "normal" off-target binding in the basal ganglia, abnormal accumulation was observed along the pyramidal tract and around the right basal ganglia as ring-shaped uptake that overlapped a gadolinium-enhanced lesion. Postmortem pathological examination revealed that she had glioblastoma multiforme with associated gliosis, in which monoamine oxidase B (MAO-B) activity is increased. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002564DOI Listing

3D reconstruction of diaphragmatic defects in CDH: a fetal MRI study.

Ultrasound Obstet Gynecol 2019 Apr 15. Epub 2019 Apr 15.

Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.

Objectives: To assess the clinical feasibility and validity of fetal MRI-based 3D reconstructions to localize, classify, and quantify diaphragmatic defects in congenital diaphragmatic hernia (CDH).

Methods: Manual segmentation of the diaphragm based on 65 in vivo and four postmortem fetal MRI scans of 46 CDH cases (gestational age 16 - 38 gestational weeks (GW)) was performed using SSFP, T2-weighted, and T1-weighted sequences and ITK-Snap. The resultant 3D models of the fetal diaphragm and its defect(s) were validated by postmortem MRI segmentation in four cases and/or comparison to a reference classification based on autopsy and surgery reports. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/uog.20296
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http://dx.doi.org/10.1002/uog.20296DOI Listing
April 2019
2 Reads

An Outcome-Based Follow-up Study of Cured Category I Pulmonary Tuberculosis Adult Cases from Various Tuberculosis Units under Revised National Tuberculosis Control Program from a Western Indian City.

Indian J Community Med 2019 Jan-Mar;44(1):48-52

Department of Community Medicine, GMERS, Medical College Sola, Ahmadabad, Gujarat, India.

Context: Despite the nationwide implementation of the Revised National Tuberculosis Control Program in India, adverse outcome after treatment is on rise. Program guidelines propose follow-up of cured patients for 2 years which is rarely done.

Objectives: The main objectives of this study is (1) To find the response of treatment in terms of failure and drug resistance (recurrence of symptoms and mortality experience) and (2) Collect client perspective about the program and suggest the same to program managers. Read More

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http://dx.doi.org/10.4103/ijcm.IJCM_310_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437808PMC

Maternal Mortality in Rural Varanasi: Delays, Causes, and Contributing Factors.

Indian J Community Med 2019 Jan-Mar;44(1):26-30

Department of Community Medicine, IMS, BHU, Varanasi, Uttar Pradesh, India.

Background: Pregnancy and motherhood are natural processes and considered to be full of positive experiences. However, for various reasons many women end up dying during pregnancy, childbirth, and the postpartum period. Improving maternal health and reducing maternal mortality have been prioritized in several international declarations and national policies. Read More

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http://dx.doi.org/10.4103/ijcm.IJCM_170_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437805PMC
April 2019
2 Reads

Challenges in classification and assignment of causes of stillbirths in low- and lower middle-income countries.

Semin Perinatol 2019 Mar 16. Epub 2019 Mar 16.

Department of Pediatrics, Division of Neonatal-Perinatal Medicine, University of North Carolina School of Medicine, UNC Hospitals - 4th Floor, 101 Manning Drive, Room N4051, Campus Box 7596, Chapel Hill, NC 27599-7596, United States.

Stillbirths account for 2.6 million deaths annually. 98% occur in low- and lower middle-income countries. Read More

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http://dx.doi.org/10.1053/j.semperi.2019.03.021DOI Listing

Death following consumption of MDAI and 5-EAPB.

Forensic Sci Int 2019 Mar 25;299:89-94. Epub 2019 Mar 25.

Laboratory of Clinical, Forensic, Industrial and Environmental Toxicology, Center for Interdisciplinary Research on Medicines (CIRM), University Hospital of Liege, Belgium.

5-(2-ethylaminopropyl)benzofuran (5-EAPB) and 5,6-methylenedioxy-2-aminoindane (MDAI) are two new psychoactive substances (NPS) exhibiting MDMA-like properties. In this paper, we report the case of a 28-years old man, known as drug addict, found dead at home, with two unidentified powders next to him. External examination by the forensic pathologist was unremarkable but no autopsy was performed. Read More

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http://dx.doi.org/10.1016/j.forsciint.2019.03.023DOI Listing

Microglia damage precedes major myelin breakdown in X-linked adrenoleukodystrophy and metachromatic leukodystrophy.

Glia 2019 Jun 11;67(6):1196-1209. Epub 2019 Feb 11.

Department of Neuropathology, University Medical Center Göttingen, Göttingen, Germany.

X-linked adrenoleukodystrophy (X-ALD) and metachromatic leukodystrophy (MLD) are two relatively common examples of hereditary demyelinating diseases caused by a dysfunction of peroxisomal or lysosomal lipid degradation. In both conditions, accumulation of nondegraded lipids leads to the destruction of cerebral white matter. Because of their high lipid content, oligodendrocytes are considered key to the pathophysiology of these leukodystrophies. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/glia.23598
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http://dx.doi.org/10.1002/glia.23598DOI Listing
June 2019
2 Reads

Potential clinical benefits and limitations of fetal virtopsy using high-field MRI at 7 Tesla versus stereomicroscopic autopsy to assess first trimester fetuses.

Prenat Diagn 2019 Apr 12. Epub 2019 Apr 12.

IMOGEN - Centre of Advanced Research Studies, Emergency County Hospital, Cluj-Napoca, Romania.

Objective: The aim of this study was to establish the diagnostic accuracy of high-field magnetic resonance imaging (MRI) at 7 Tesla (T) compared to that of stereomicroscopic autopsy for assessing first trimester fetuses.

Methods: Nine consecutive cases of first trimester fetuses resulting from spontaneous and therapeutic pregnancy termination were considered. The cases were divided into two groups according to gestational age: the Embryo Group with cases of 9-10 gestational weeks (GW) and the Fetus Group with cases of 13 GW. Read More

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http://dx.doi.org/10.1002/pd.5457DOI Listing

Vein "Beltization" Technique Facilitates Venous Anastomoses for Laparoscopic Orthotopic Kidney Transplantation in a Pig Model.

Transplant Proc 2019 Apr 9;51(3):913-918. Epub 2019 Jan 9.

Liver and Kidney Transplant Service, Sir Charles Gairdner Hospital, School of Surgery, The University of Western Australia, Nedlands, Perth, Australia.

Objective: This study was performed to investigate the safety and efficiency of the renal vein "beltization" technique for laparoscopic orthotopic kidney transplantation (LOKT) in a pig model.

Material And Methods: Kidney autotransplants were conducted, in which the renal vein beltization technique was employed, in 12 domestic pigs. In the operation, the right kidney was autotransplanted to the left kidney vessel trunks. Read More

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http://dx.doi.org/10.1016/j.transproceed.2019.01.034DOI Listing

Cardiac left ventricular myocardial tissue density, evaluated by computed tomography and autopsy.

BMC Med Imaging 2019 04 12;19(1):29. Epub 2019 Apr 12.

Section of Forensic Pathology, Department of Forensic Medicine, University of Copenhagen, Frederik V's vej 11, 1 sal, 2100, Copenhagen, Denmark.

Background: Left ventricular mass (LVM) is an independent risk factor for the prediction of cardiac events. Its assessment is a clinically important diagnostic procedure in cardiology and may be performed by Computed Tomography (CT). The aim of this study was to assess the correlation between the cardiac left ventricular shell volume (LVShV) determined by postmortem Computed Tomography (PMCT) and the anatomic LVM obtained at autopsy and to calculate the myocardial tissue density. Read More

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https://bmcmedimaging.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12880-019-0326-4DOI Listing
April 2019
1 Read

Coexistence of Gastric Cancer and Multiple Small Gastrointestinal Stromal Tumors: Report of a Unique Case and Review of the Literature.

Authors:
Helen J Trihia

Gastrointest Tumors 2019 Feb 21;5(3-4):63-67. Epub 2018 Dec 21.

Department of Pathology, "Metaxas" Cancer Hospital, Piraeus, Greece.

Background: In recent years, the synchronous occurrence of tumors of different histotypes arising in the same organ has been reported more frequently in the literature. The simultaneous development of adenocarcinoma and gastrointestinal stromal tumor (GIST) has been documented rarely.

Summary: The coexistence of primary gastric adenocarcinoma and GIST has been detected incidentally on gastric mucosa, serosa or occasionally intramurally, at surgery, or gastroscopy for other reasons. Read More

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http://dx.doi.org/10.1159/000495178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422145PMC
February 2019
1 Read

Issues in the handling of cases of tuberculosis in the mortuary.

J Forensic Leg Med 2019 Apr 6;64:42-44. Epub 2019 Apr 6.

Forensic Science South Australia (FSSA) and the School of Medicine, The University of Adelaide, Adelaide, South Australia, 5000, Australia. Electronic address:

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (MTB) that is most often transmitted by the inhalation of bacteria-containing aerosols. While there has been a decline in numbers of cases in certain countries, large population movements, the increasing emergence of drug-resistant strains and the association with human immunodeficiency virus (HIV) infection make it a disease that is increasingly seen in forensic practice. Mortuary staff are at risk of infection from penetrating sharp injuries, droplet inhalation, ingestion, direct inoculation, through skin breaks or through mucous membranes of the eyes, nose and mouth. Read More

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http://dx.doi.org/10.1016/j.jflm.2019.04.002DOI Listing
April 2019
1 Read

Expression of aldosterone synthase CYP11B2 was inversely correlated with longevity.

J Steroid Biochem Mol Biol 2019 Apr 8. Epub 2019 Apr 8.

Department of Uro-Oncology, Saitama Medical University International Medical Center, Saitama, Japan; Department of Biochemistry, Keio University School of Medicine, Tokyo, Japan. Electronic address:

Immunohistochemistry of human aldosterone synthase (CYP11B2) has revealed that most of aldosterone is autonomously produced in aldosterone-producing cell clusters (APCCs) beneath the capsule of adult adrenals rather than physiologically in the zona glomerulosa (ZG). APCCs have been occasionally found to harbor a somatic mutation of ion channel/pump genes, and number and size of APCCs increase with age until 50 years old. Herein, the objective of the study was to examine APCC development in 106 autopsied adrenals from 85 elderly individuals who died at ages from 50 to 103 years. Read More

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http://dx.doi.org/10.1016/j.jsbmb.2019.04.010DOI Listing

Air contamination during medical treatment results in deposits of microemboli in the lungs: An autopsy study.

Int J Artif Organs 2019 Apr 11:391398819840363. Epub 2019 Apr 11.

2 Department of Public Health and Clinical Medicine, Faculty of Medicine, Umeå University, Umeå, Sweden.

Introduction: Microbubbles of air may enter into patients during conventional hemodialysis, infusions of fluids, or by injections. The aim of this study was to investigate whether the air that enters the patient during hemodialysis can be detected in the lungs after death, and if so, whether this may be related to tissue damage.

Methods: The material consisted of lung tissue from five chronic hemodialysis patients who died either during (two) or after hemodialysis (range 10 min from start until 3333 min after the last hemodialysis session); as reference group tissue was taken from seven patients who died due to amyotrophic lateral sclerosis. Read More

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http://dx.doi.org/10.1177/0391398819840363DOI Listing
April 2019
1 Read

Gastrointestinal impactions in backyard poultry.

J Vet Diagn Invest 2019 Apr 11:1040638719843966. Epub 2019 Apr 11.

California Animal Health and Food Safety Laboratory System, University of California, San Bernardino branch (Carvallo).

In contrast to conventional commercial poultry, which are raised primarily in controlled indoor environments, backyard poultry are typically raised in less restricted settings, potentially exposing them to a greater variety of ingestible substances, including multiple types of forage. Consequently, problems such as gastrointestinal impactions caused by ingesta have been noted in backyard poultry. To determine the prevalence of these impactions in backyard poultry, we performed a retrospective database search for autopsy submissions to the California Animal Health and Food Safety laboratory system and found that gastrointestinal impaction was associated with the death of 42 backyard poultry cases (40 chickens, 1 turkey, and 1 goose) from January 2013 to July 2018. Read More

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http://dx.doi.org/10.1177/1040638719843966DOI Listing

Surveillance for Avibacterium paragallinarum in autopsy cases of birds from small chicken flocks using a real-time PCR assay.

J Vet Diagn Invest 2019 Apr 11:1040638719844297. Epub 2019 Apr 11.

California Animal Health and Food Safety Laboratory System, School of Veterinary Medicine, University of California-Davis, Davis, CA.

Infectious coryza is a severe respiratory disease of chickens associated with large economic losses in affected commercial flocks. The fastidious causative pathogen, Avibacterium paragallinarum, is difficult to recover and identify, resulting in delayed diagnosis and enhanced spread of the agent. Small poultry flocks are increasingly common in rural and suburban environments. Read More

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http://dx.doi.org/10.1177/1040638719844297DOI Listing
April 2019
1 Read

Approaching pulmonary fat embolism on postmortem computed tomography.

Int J Legal Med 2019 Apr 10. Epub 2019 Apr 10.

Department of Forensic Medicine and Imaging, Institute of Forensic Medicine, University of Zurich, Winterthurerstrasse 190/52, CH-8057, Zurich, Switzerland.

Purpose: Pulmonary fat embolism (PFE) is a relevant diagnosis playing a role as a sign of vitality or a cause of death. Its severity is assessed according to histological grading systems like that of Falzi. The aim of this study was to determine the utility of unenhanced postmortem computed tomography (PMCT) for PFE diagnosis based on the detection of fat layers. Read More

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http://link.springer.com/10.1007/s00414-019-02055-8
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http://dx.doi.org/10.1007/s00414-019-02055-8DOI Listing
April 2019
2 Reads

Anticancer Activities of L. in Experimental Breast Carcinoma in Vivo and in Vitro.

Int J Mol Sci 2019 Apr 9;20(7). Epub 2019 Apr 9.

Weill Cornell Medicine in Qatar, Qatar Foundation-Education City, Doha 24144, Qatar.

Naturally-occurring mixtures of phytochemicals present in plant foods are proposed to possess tumor-suppressive activities. In this work, we aimed to evaluate the antitumor effects of L. in in vivo and in vitro mammary carcinoma models. Read More

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http://dx.doi.org/10.3390/ijms20071749DOI Listing
April 2019
2.862 Impact Factor

Feasibility of Postmortem Imaging Assessment of Brain: Liver Volume Ratios with Pathological Validation.

Fetal Diagn Ther 2019 Apr 10:1-8. Epub 2019 Apr 10.

Department of Radiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom.

Introduction: Organ volumes at postmortem magnetic resonance imaging (PMMR) should reflect autopsy organ weights, and thus brain:liver volume ratios on imaging could be a surrogate for weight volume ratios at autopsy to indicate fetal growth restriction (FGR). This study aims to determine whether imaging-based organ volume ratios can replace autopsy organ weight ratios. Materials and Meth ods: An unselected cohort of perinatal deaths underwent PMMR prior to autopsy. Read More

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http://dx.doi.org/10.1159/000497158DOI Listing
April 2019
2 Reads

Organ Weight Reference Ranges for Ages 0 to 12 Years.

Am J Forensic Med Pathol 2019 Apr 8. Epub 2019 Apr 8.

Office of the Medical Examiner, Maricopa County, Phoenix, AZ.

Abnormal organ weights often serve as an indicator of underlying disease or other pathological process making assessment of organ weight a critical part of the autopsy examination and interpretation. Unfortunately, normal organ weights for children are often based on studies done in the 1930s and 1960s. Thus, the present study was designed to accurately assess organ weights in children to establish reference ranges for use in autopsy examinations. Read More

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http://dx.doi.org/10.1097/PAF.0000000000000481DOI Listing
April 2019
1 Read

Extensive study on electrocution at the Bureau of Legal Medicine of Milan (1993-2017): Determination of the current mark with scanning electron microscope/energy-dispersive X-ray analysis on paraffin-embedded samples.

Med Leg J 2019 Apr 10:25817219833328. Epub 2019 Apr 10.

1 Dipartimento di Scienze Biomediche per la Salute, Sezione di Medicina Legale e delle Assicurazioni, Università degli Studi di Milano, Milano, Italy.

Literature on electrocution in Italy is limited. The authors have focused their attention on the use of scanning electron microscope/energy-dispersive X-ray analysis in order to evaluate the current mark even on paraffin-embedded samples. A total of 24,104 autopsies were performed at the Section of Legal Medicine of Milan (1993-2017); all cases of death caused by electrocution (low and high voltage) were selected. Read More

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http://dx.doi.org/10.1177/0025817219833328DOI Listing

Non-small cell lung cancer presenting as "psoas muscle syndrome".

Monaldi Arch Chest Dis 2019 Apr 5;89(1). Epub 2019 Apr 5.

Department of Translational Medical Sciences, University of Campania "L. Vanvitelli", Monaldi Hospital, Naples.

Lung cancer is the leading cause of cancer-related death worldwide and majority of patients are diagnosed in advanced/metastatic disease stage. Sites of distant metastases mainly include contralateral lung, lymph nodes, brain, bones, adrenal glands and liver; skeletal muscles metastases (SMMs) are less common. Psoas muscle and diaphragm metastases are mainly found during autopsy, as their involvement commonly is asymptomatic. Read More

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https://www.monaldi-archives.org/index.php/macd/article/view
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http://dx.doi.org/10.4081/monaldi.2019.1012DOI Listing
April 2019
6 Reads

Accuracy of Micro-Computed Tomography in Post-mortem Evaluation of Fetal Congenital Heart Disease. Comparison Between Post-mortem Micro-CT and Conventional Autopsy.

Front Pediatr 2019 22;7:92. Epub 2019 Mar 22.

Division of Cardiac Surgery, Department of Surgery, Dentistry, Pediatrics and Gynecology, University of Verona, Verona, Italy.

Early prenatal diagnosis of congenital heart disease is feasible. Conventional autopsy is the current gold standard method for post-mortem confirmation. Radiologic techniques alternative to conventional autopsy, such as post-mortem micro-computed tomography, have been proposed in case of limited diagnostic accuracy (i. Read More

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http://dx.doi.org/10.3389/fped.2019.00092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440368PMC
March 2019
1 Read

Macrophages of the subcutaneous and omental fatty tissue in obese patients: Immunohistochemical phenotyping of M2 subtypes in relation to type 2 diabetes.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2019 Apr 9. Epub 2019 Apr 9.

Department of Histology and Embryology, Faculty of Medicine University of Ostrava, Ostrava, Czech Republic.

Background And Aims: Macrophages are linked to the initiation of the chronic inflammation believed to underlie the changes taking place in the white fatty tissue of obese people. Both the number of macrophages, but their functional status, play an important role in the development of inflammation. Classically, macrophages are divided into two types: pro-inflammatory (M1) and anti-inflammatory (M2) types, and based on current immunological studies, further views on the functional distribution of macrophages are suggested. Read More

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http://dx.doi.org/10.5507/bp.2019.011DOI Listing

Levels of trace elements and potential toxic elements in bovine livers: A trend analysis from 2007 to 2018.

PLoS One 2019 9;14(4):e0214584. Epub 2019 Apr 9.

Animal Health Services, AA Deventer, The Netherlands.

Trace elements and potential toxic elements were analyzed in bovine livers submitted for autopsy in the Netherlands during the years 2007 to 2018. The age of each animal was recorded. In total, 1544 livers were analyzed for cadmium, cobalt, chromium, copper, iron, molybdenum, nickel, lead, selenium and zinc. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214584PLOS

Corticosteroid-induced immunodeficiency in a patient with gliomatosis cerebri: Are corticosteroids indicated in all brain tumors?

Clin Neuropathol 2019 Apr 9. Epub 2019 Apr 9.

An elderly male was admitted to the Department of Neurology for slowly progressive dysarthria and right-sided atactic hemiparesis. Magnetic resonance imaging (MRI) revealed a small contrast-enhanced focus of malignant glioma in the left parietal lobe - with the growth pattern of cerebral gliomatosis - involving the whole left cerebral hemisphere, the corpus callosum, and spreading into the right frontal hemisphere. Diagnostic biopsy was deferred until the exclusion of other possible causes of the brain lesion. Read More

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http://dx.doi.org/10.5414/NP301167DOI Listing
April 2019
1 Read

Modified contralateral C7 nerve transfer: the possibility of permitting ulnar nerve recovery is confirmed by 10 cases of autopsy.

Neural Regen Res 2019 Aug;14(8):1449-1454

Department of Hand Surgery, Huashan Hospital, Fudan University; Key Laboratory of Hand Reconstruction, Ministry of Health; Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, Shanghai, China.

Contralateral C7 nerve transfer surgery is one of the most important surgical techniques for treating total brachial plexus nerve injury. In the traditional contralateral C7 nerve transfer surgery, the whole ulnar nerve on the paralyzed side is harvested for transfer, which completely sacrifices its potential of recovery. In the present, novel study, we report on the anatomical feasibility of a modified contralateral C7 nerve transfer surgery. Read More

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http://dx.doi.org/10.4103/1673-5374.253530DOI Listing
August 2019
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An 18th century description of endometriosis : The autopsy of the Countess von Reitzenstein.

Wien Med Wochenschr 2019 Apr 8. Epub 2019 Apr 8.

Department of Pathology H4.312, University Medical Center Utrecht, Utrecht, The Netherlands.

Descriptions of endometriosis in 18th century monographs and manuscripts are rare and the recorded macroscopic features of endometriosis seldom support this attribution to the described cases. Recently, we became aware of an anonymous German autopsy report from the 18th century. After transcription, the manuscript was assessed by pathologists with historical expertise. Read More

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http://dx.doi.org/10.1007/s10354-019-0693-zDOI Listing
April 2019
2 Reads

Gamna-Gandy bodies of the spleen in sickle cell disease.

Autops Case Rep 2019 Apr-Jun;9(2):e2018076. Epub 2019 Mar 22.

Universidade de São Paulo (USP), Faculty of Medicine, Department of Pathology. São Paulo, SP, Brazil.

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http://www.autopsyandcasereports.org/article/doi/10.4322/acr
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http://dx.doi.org/10.4322/acr.2018.076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433140PMC
March 2019
3 Reads

Fatal necrotizing esophagitis in a patient with leukocytoclastic cutaneous vasculitis and ankylosing spondylitis.

Autops Case Rep 2019 Apr-Jun;9(2):e2018070. Epub 2019 Mar 22.

Universidade de São Paulo (USP), Hospital Universitário, Internal Medicine Division. São Paulo, SP, Brazil.

Esophageal infection by spp. is a common opportunistic entity in immunocompromised hosts; however, systemic fungal dissemination due to perforation or transmural necrosis, also known as necrotizing esophagitis (NCE), is rare. We report the case of a 61-year-old male patient with diagnosed ankylosing spondylitis, severe arteriosclerosis, and vasculitis under immunosuppressive therapy who presented NCE with fungal and bacterial septicemia diagnosed at autopsy. Read More

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http://www.autopsyandcasereports.org/article/doi/10.4322/acr
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http://dx.doi.org/10.4322/acr.2018.070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433139PMC
March 2019
3 Reads

Clinicopathological and Genetic Profiles of Cases with Myocytes Disarray-Investigation for Establishing the Autopsy Diagnostic Criteria for Hypertrophic Cardiomyopathy.

J Clin Med 2019 Apr 5;8(4). Epub 2019 Apr 5.

Department of Legal Medicine, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan.

Myocyte disarray of >10% in the heart is broadly accepted as a diagnostic pitfall for hypertrophic cardiomyopathy (HCM) at postmortem. The present study aims to propose an additional diagnostic criterion of HCM. Heart specimens from 1387 serial forensic autopsy cases were examined. Read More

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http://dx.doi.org/10.3390/jcm8040463DOI Listing
April 2019
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Sudden Unexpected Death in a Child From an Anaplastic Ependymoma.

Am J Forensic Med Pathol 2019 Apr 2. Epub 2019 Apr 2.

N.C. Office of the Chief Medical Examiner, Raleigh, NC.

Primary central nervous system tumors are an extremely rare cause of sudden, unexpected death in children as most patients develop symptoms because of increased intracranial pressure and seek medical attention. Rarely, a forensic pathologist may encounter a primary intracranial neoplasm in a pediatric decedent that was not suspected before death. Herein, we present a case of a supratentorial neuroepithelial tumor found at autopsy in a 3-year-old African American boy without any reported significant medical history. Read More

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http://dx.doi.org/10.1097/PAF.0000000000000480DOI Listing

Gastric Heterotopic Pancreas Presenting as Abdominal Pain with Acute and Chronic Pancreatitis in the Resected Specimen.

Case Rep Gastrointest Med 2019 6;2019:2021712. Epub 2019 Mar 6.

Warren Alpert Medical School, Brown University, Providence, RI, USA.

Heterotopic pancreas, also known as ectopic pancreas, is pancreatic tissue located outside the pancreatic parenchyma without vascular or ductal communication with the gland. Ectopic pancreas is rarely symptomatic, typically detected incidentally at surgery or autopsy. Eighty-five to 90% are in the upper GI tract, especially the gastric antrum. Read More

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http://dx.doi.org/10.1155/2019/2021712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431401PMC
March 2019
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Homicide or car accident: The case of the 'guilty' fibre.

Med Leg J 2019 Apr 8:25817219830275. Epub 2019 Apr 8.

1 Department of Clinical and Experimental Medicine, Section of Legal Medicine, University of Foggia, Foggia, Italy.

Crime scene investigation should be carried out using a critical forensic approach by an expert team. This provides essential tools in the research and collection of evidence and samples which must be integrated with the autopsy and the police officers' investigations. This paper aims to highlight the importance of a multidisciplinary approach to crime scene investigation and describes a very interesting criminal case. Read More

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http://dx.doi.org/10.1177/0025817219830275DOI Listing