185 results match your criteria Autonomic Neuroscience: Basic & Clinical [Journal]


Impairments in cognitive performance in chronic fatigue syndrome are common, not related to co-morbid depression but do associate with autonomic dysfunction.

PLoS One 2019 5;14(2):e0210394. Epub 2019 Feb 5.

Institute of Cellular Medicine, Newcastle University, Newcastle, United Kingdom.

Objectives: To explore cognitive performance in chronic fatigue syndrome (CFS) examining two cohorts. To establish findings associated with CFS and those related to co-morbid depression or autonomic dysfunction.

Methods: Identification and recruitment of participants was identical in both phases, all CFS patients fulfilled Fukuda criteria. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210394PLOS
February 2019
1 Read

Augmentation of Whole-Body Metabolic Status by Mind-Body Training: Synchronous Integration of Tissue- and Organ-Specific Mitochondrial Function.

Med Sci Monit Basic Res 2019 Jan 11;25:8-14. Epub 2019 Jan 11.

Department of Psychiatry, First Faculty of Medicine Charles University in Prague and General University Hospital in Prague, Center for Cognitive and Molecular Neuroscience, Prague, Czech Republic.

The objective of our concise review is to elaborate an evidence-based integrative medicine model that incorporates functional linkages of key aspects of cortically-driven mind-body training procedures to biochemical and molecular processes driving enhanced cellular bioenergetics and whole-body metabolic advantage. This entails the adoption of a unified biological systems approach to selectively elucidate basic biochemical and molecular events responsible for achieving physiological relaxation of complex cellular structures. We provide accumulated evidence in support of the potential synergy of voluntary breathing exercises in combination with meditation and/or complementary cognitive tasks to promote medically beneficial enhancements in whole-body relaxation, anti-stress mechanisms, and restorative sleep. Read More

View Article

Download full-text PDF

Source
https://basic.medscimonit.com/abstract/index/idArt/913264
Publisher Site
http://dx.doi.org/10.12659/MSMBR.913264DOI Listing
January 2019
4 Reads

Interaction Between Stress and Addiction: Contributions From Latin-American Neuroscience.

Front Psychol 2018 21;9:2639. Epub 2018 Dec 21.

Neuroscience Research Group, Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia.

Drug addiction is a chronic neuropsychiatric disorder that escalates from an initial exposure to drugs of abuse, such as cocaine, cannabis, or heroin, to compulsive drug-seeking and intake, reduced ability to inhibit craving-induced behaviors, and repeated cycles of abstinence and relapse. It is well-known that chronic changes in the brain's reward system play an important role in the neurobiology of addiction. Notably, environmental factors such as acute or chronic stress affect this system, and increase the risk for drug consumption and relapse. Read More

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fpsyg.2018.02639
Publisher Site
http://dx.doi.org/10.3389/fpsyg.2018.02639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308142PMC
December 2018
4 Reads

A novel nonsense mutation in WNK1/HSN2 associated with sensory neuropathy and limb destruction in four siblings of a large Iranian pedigree.

BMC Neurol 2018 Nov 29;18(1):195. Epub 2018 Nov 29.

Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Hereditary sensory and autonomic neuropathy type 2 (HSAN2) is an autosomal recessive disorder with predominant sensory dysfunction and severe complications such as limb destruction. There are different subtypes of HSAN2, including HSAN2A, which is caused by mutations in WNK1/HSN2 gene.

Methods: An Iranian family with four siblings and autosomal recessive inheritance pattern whom initially diagnosed with HSAN2 underwent whole exome sequencing (WES) followed by segregation analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12883-018-1201-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262971PMC
November 2018
3 Reads

Classical paintings may trigger pain and pleasure in the gendered brain.

Cortex 2018 Dec 28;109:171-180. Epub 2018 Sep 28.

Brain and Emotion Laboratory, Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, the Netherlands.

The human body is the most common object of pictorial representation in western art and its representations trigger a vast range of experiences from pain to pleasure. The goal of this study was to investigate brain activity triggered by paintings of male and female body images exemplifying conditions associated with pleasure or pain. Our findings show participant-general as well as gender specific brain activity for either the pain or the pleasure conditions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cortex.2018.09.011DOI Listing
December 2018
2 Reads

EEG and autonomic responses to nociceptive stimulation in disorders of consciousness.

J Clin Neurosci 2019 Feb 9;60:101-106. Epub 2018 Oct 9.

Research Unit in Affective and Social Neuroscience, Catholic University of the Sacred Heart, Milano, Italy; Department of Psychology, Catholic University of the Sacred Heart, Milano, Italy.

Since behavioral responses to external stimuli of patients presenting disorders of consciousness (DoC) are often difficult to qualify, covert physiological correlates of responsivity are deemed as potentially valuable tools to help assessment procedures. While noxious stimuli seem good candidates to explore DoC patients' responsivity, autonomic and electrophysiological correlates of pain detection in DoC patients are still debated. This research aims at investigating autonomic and cortical activation as covert measure of residual somatosensory and nociceptive processes in patients in vegetative state. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jocn.2018.09.020DOI Listing
February 2019
1 Read

The sympathetic nervous system regulates skeletal muscle motor innervation and acetylcholine receptor stability.

Acta Physiol (Oxf) 2019 Mar 22;225(3):e13195. Epub 2018 Oct 22.

Department of Internal Medicine, Gerontology, Wake Forest School of Medicine, Winston-Salem, North Carolina.

Aim: Symptoms of autonomic failure are frequently the presentation of advanced age and neurodegenerative diseases that impair adaptation to common physiologic stressors. The aim of this work was to examine the interaction between the sympathetic and motor nervous system, the involvement of the sympathetic nervous system (SNS) in neuromuscular junction (NMJ) presynaptic motor function, the stability of postsynaptic molecular organization, and the skeletal muscle composition and function.

Methods: Since muscle weakness is a symptom of diseases characterized by autonomic dysfunction, we studied the impact of regional sympathetic ablation on muscle motor innervation by using transcriptome analysis, retrograde tracing of the sympathetic outflow to the skeletal muscle, confocal and electron microscopy, NMJ transmission by electrophysiological methods, protein analysis, and state of the art microsurgical techniques, in C57BL6, MuRF1KO and Thy-1 mice. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/apha.13195
Publisher Site
http://dx.doi.org/10.1111/apha.13195DOI Listing
March 2019
8 Reads
4.382 Impact Factor

Neurophysiological correlates of clinical improvement after greater occipital nerve (GON) block in chronic migraine: relevance for chronic migraine pathophysiology.

J Headache Pain 2018 Aug 20;19(1):73. Epub 2018 Aug 20.

Headache Centre & Neurocritical Care Unit. Department of Human Neurosciences, Sapienza - University of Rome, Viale dell'Università 30, 00185, Rome, Italy.

Background: Therapeutic management of Chronic Migraine (CM), often associated with Medication Overuse Headache (MOH), is chiefly empirical, as no biomarker predicting or correlating with clinical efficacy is available to address therapeutic choices. The present study searched for neurophysiological correlates of Greater Occipital Nerve Block (GON-B) effects in CM.

Methods: We recruited 17 CM women, of whom 12 with MOH, and 19 healthy volunteers (HV). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s10194-018-0901-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102162PMC
August 2018
20 Reads

Role of microglia M1/M2 polarisation in the paraventricular nucleus: New insight into the development of stress-induced hypertension in rats.

Auton Neurosci 2018 Sep 12;213:71-80. Epub 2018 Jun 12.

School of Life Sciences, Shanghai University, 333 Nanchen Road, Shanghai 200444, PR China. Electronic address:

The lack of precise therapies for stress-induced hypertension highlights the need to explore the process of blood pressure changes. Studies have shown that neuroinflammation in the central nervous system is associated with hypertension, although the mechanisms remain elusive. Microglia, are known to play dualistic protective and destructive roles, representing logical but challenging targets for improving stress-induced hypertension. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autneu.2018.06.003DOI Listing
September 2018
11 Reads

Brain structure and function related to headache: Brainstem structure and function in headache.

Cephalalgia 2018 Jan 1:333102418784698. Epub 2018 Jan 1.

3 Department of Neural and Pain Sciences, University of Maryland Baltimore, Baltimore, MD, USA.

Objective To review and discuss the literature relevant to the role of brainstem structure and function in headache. Background Primary headache disorders, such as migraine and cluster headache, are considered disorders of the brain. As well as head-related pain, these headache disorders are also associated with other neurological symptoms, such as those related to sensory, homeostatic, autonomic, cognitive and affective processing that can all occur before, during or even after headache has ceased. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0333102418784698DOI Listing
January 2018
14 Reads

A detailed clinical study of pain in 1957 participants with early/moderate Parkinson's disease.

Parkinsonism Relat Disord 2018 Nov 6;56:27-32. Epub 2018 Jun 6.

Department of Neurology, Institute of Neurological Sciences, Queen Elizabeth University Hospital, Glasgow, United Kingdom.

Introduction: The causes of pain in early/moderate Parkinson's disease (PD) are not well understood. Although peripheral factors such as rigidity, reduced joint movements and poor posture may contribute towards the development of pain, central mechanisms including altered nociceptive processing may also be involved.

Methods: We performed a large clinical study to investigate potential factors contributing towards pain in early/moderate PD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.parkreldis.2018.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302227PMC
November 2018
5 Reads

The Role of the Periaqueductal Gray Matter in Lower Urinary Tract Function.

Mol Neurobiol 2018 May 26. Epub 2018 May 26.

Department of Urology, Maastricht University Medical Center, Maastricht, The Netherlands.

The periaqueductal gray matter (PAG), as one of the mostly preserved evolutionary components of the brain, is an axial structure modulating various important functions of the organism, including autonomic, behavioral, pain, and micturition control. It has a critical role in urinary bladder physiology, with respect to storage and voiding of urine. The PAG has a columnar composition and has extensive connections with its cranially and caudally located components of the central nervous system (CNS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12035-018-1131-8DOI Listing
May 2018
21 Reads
5.137 Impact Factor

Time-dependent changes in cardiorespiratory functions of anesthetized rats exposed to sustained hypoxia.

Auton Neurosci 2018 Jul 14;212:1-9. Epub 2018 Mar 14.

Laboratory of Veterinary Anatomy and Cell Biology, Faculty of Agriculture, Iwate University, 18-8, Ueda 3-chome, Morioka, Iwate 020-8550, Japan; Department of Basic Veterinary Science, United Graduate School of Veterinary Science, Gifu University, 1-1, Yanagido, Gifu 501-1193, Japan. Electronic address:

Although cardiovascular responses may be altered by respiratory changes under prolonged hypoxia, the relationship between respiratory and cardiovascular changes remains unknown. The aim of the present study is to clarify cardiorespiratory changes in anesthetized rats during and after hypoxic conditions using simultaneous recordings of cardiorespiratory variables with 20-sec recording intervals. After air breathing for 20 min (pre-exposure period), rats were subjected to 10% O for 2 h (hypoxic exposure period) and then air for 30 min (recovery period). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autneu.2018.03.002DOI Listing
July 2018
2 Reads

Overview of Trigeminal Autonomic Cephalalgias: Nosologic Evolution, Diagnosis, and Management.

Ann Indian Acad Neurol 2018 Apr;21(Suppl 1):S39-S44

Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, United Kingdom.

The term trigeminal autonomic cephalalgias (TACs) encompasses four primary headache disorders - cluster headache, paroxysmal hemicrania (PH), hemicrania continua (HC), short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT)/short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms (SUNA). All of these except HC are characterized by short-lasting headaches. HC is characterized by a continuous unilateral headache that waxes and wanes in its intensity without complete resolution. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/aian.AIAN_348_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909133PMC
April 2018
4 Reads

Cluster Headache: Epidemiology, Pathophysiology, Clinical Features, and Diagnosis.

Ann Indian Acad Neurol 2018 Apr;21(Suppl 1):S3-S8

Department of Basic and Clinical Neuroscience, Headache Group, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Cluster headache is a primary headache disorder affecting up to 0.1% of the population. Patients suffer from cluster headache attacks lasting from 15 to 180 min up to 8 times a day. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/aian.AIAN_349_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909131PMC
April 2018
3 Reads

Involvement of Neuroinflammation in the Pathogenesis of Monocrotaline-Induced Pulmonary Hypertension.

Hypertension 2018 Jun 30;71(6):1156-1163. Epub 2018 Apr 30.

From the Department of Physiology and Functional Genomics (R.K.S., A.C.O., S.K., G.L., V.A., E.M.R., M.K.R.)

Pulmonary hypertension (PH) is a devastating disease and its successful treatment remains to be accomplished despite recent advances in pharmacotherapy. It has been proposed that PH be considered as a systemic disease, rather than primarily a disease of the pulmonary vasculature. Consequently, an investigation of the intricate interplay between multiple organs such as brain, vasculature, and lung in PH could lead to the identification of new targets for its therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.10934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945302PMC
June 2018
10 Reads
1 Citation
6.480 Impact Factor

Therapeutic Approaches for the Management of Trigeminal Autonomic Cephalalgias.

Neurotherapeutics 2018 04;15(2):346-360

Danish Headache Centre, Department of Neurology, Rigshospitalet-Glostrup, University of Copenhagen, Copenhagen, Denmark.

Trigeminal autonomic cephalalgia (TAC) encompasses 4 unique primary headache types: cluster headache, paroxysmal hemicrania, hemicrania continua, and short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing and short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms. They are grouped on the basis of their shared clinical features of unilateral headache of varying durations and ipsilateral cranial autonomic symptoms. The shared clinical features reflect the underlying activation of the trigeminal-autonomic reflex. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13311-018-0618-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935647PMC
April 2018
6 Reads

Investigating Misophonia: A Review of the Empirical Literature, Clinical Implications, and a Research Agenda.

Front Neurosci 2018 7;12:36. Epub 2018 Feb 7.

International Misophonia Research Network, New York, NY, United States.

Misophonia is a neurobehavioral syndrome phenotypically characterized by heightened autonomic nervous system arousal and negative emotional reactivity (e. g., irritation, anger, anxiety) in response to a decreased tolerance for specific sounds. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnins.2018.00036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808324PMC
February 2018
9 Reads

Long Non-coding RNA BC168687 is Involved in TRPV1-mediated Diabetic Neuropathic Pain in Rats.

Neuroscience 2018 03 5;374:214-222. Epub 2018 Feb 5.

Department of Physiology, Basic Medical College of Nanchang University, Nanchang 330006, PR China; Jiangxi Provincial Key Laboratory of Autonomic Nervous Function and Disease, Nanchang 330006, PR China. Electronic address:

Long noncoding RNAs (lncRNAs) participate in a diverse range of molecular and biological processes, and dysregulation of lncRNAs has been observed in the pathogenesis of various human diseases. We observed alterations in mechanical withdrawal thresholds (MWT) and thermal withdrawal latencies (TWL) in streptozotocin (STZ)-induced diabetic rats treated with small interfering RNA (siRNA) of lncRNA BC168687. We detected expression of transient receptor potential vanilloid type 1 (TRPV1) in rat dorsal root ganglia (DRG) by a series of molecular experiments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuroscience.2018.01.049DOI Listing
March 2018
8 Reads

Treatment of disabling headache with greater occipital nerve injections in a large population of childhood and adolescent patients: a service evaluation.

J Headache Pain 2018 Jan 16;19(1). Epub 2018 Jan 16.

Department of Paediatric Neurology, Great Ormond Hospital for Children NHS Foundation Trust, London, UK.

Background: Pediatric headache disorders can be extremely disabling, with marked reduction in the quality of life of children and their carers. Evidenced-based options for the treatment of primary headache disorders with preventive medication is limited and clinical outcomes are often unsatisfactory. Greater occipital nerve injections represent a rapid and well-tolerated therapeutic option, which is widely used in clinical practice in adults, and has previously shown a good outcome in a pediatric population. Read More

View Article

Download full-text PDF

Source
https://thejournalofheadacheandpain.biomedcentral.com/articl
Publisher Site
http://dx.doi.org/10.1186/s10194-018-0835-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770345PMC
January 2018
14 Reads

Cluster headache and the trigeminal-autonomic reflex: Driving or being driven?

Authors:
Peter J Goadsby

Cephalalgia 2018 Jul 30;38(8):1415-1417. Epub 2017 Oct 30.

1 Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0333102417738252DOI Listing
July 2018
6 Reads

International spinal cord injury male sexual function and female sexual and reproductive function basic data sets-version 2.0.

Spinal Cord Ser Cases 2017 10;3:17050. Epub 2017 Aug 10.

Spinal Unit, Centre Calve, Fondation Hopale, Berck-sur-Mer, France.

Study Design: Data set review and modification.

Objective: To describe modifications in the International Spinal Cord Injury (SCI) Male Sexual Function Basic Data Set Version 2.0 and the International SCI Female Sexual and Reproductive Function Basic Data Set Version 2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/scsandc.2017.50DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550926PMC
August 2017
13 Reads

Anatomical Organization of Urocortin 3-Synthesizing Neurons and Immunoreactive Terminals in the Central Nervous System of Non-Human Primates [ spp.].

Front Neuroanat 2017 24;11:57. Epub 2017 Jul 24.

Department of Anatomy, Institute of Biomedical Sciences, University of São PauloSão Paulo, Brazil.

Urocortin 3 (UCN3) is a neuropeptide member of the corticotropin-releasing factor (CRF) peptide family that acts as a selective endogenous ligand for the CRF, subtype 2 (CRF) receptor. Immunohistochemistry and hybridization data from rodents revealed UCN3-containing neurons in discrete regions of the central nervous system (CNS), such as the medial preoptic nucleus, the rostral perifornical area (PFA), the medial nucleus of the amygdala and the superior paraolivary nucleus. UCN3-immunoreactive (UCN3-ir) terminals are distributed throughout regions that mostly overlap with regions of CRF messenger RNA (mRNA) expression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnana.2017.00057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522884PMC
July 2017
8 Reads

Heart rate variability is enhanced by long-lasting pleasant touch at CT-optimized velocity.

Biol Psychol 2017 09 16;128:71-81. Epub 2017 Jul 16.

Dept. of Psychology, University of Gothenburg, Gothenburg, Sweden; Dept. of Behavioral Sciences in Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.

Introduction: The present study explores whether long-lasting pleasant touch has positive effects on the stress response, reward sensitivity, mood, and interoceptive awareness.

Methods: 40 participants received either 35min of brush stroking targeting C-tactile fibres (CT) or vibration on the forearm, and rated pleasantness and intensity. Prior and after, stress response (cortisol and heart rate variability), reward sensitivity, mood and interoceptive awareness were measured. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biopsycho.2017.07.007DOI Listing
September 2017
2 Reads

Parkinson's Disease: Basic Pathomechanisms and a Clinical Overview.

Adv Neurobiol 2017 ;15:55-92

Department of Molecular Neuroscience, Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, 1, Wakefield Street, London, WC1N 1PJ, UK.

PD is a common and a debilitating degenerative movement disorder. The number of patients is increasing worldwide and as yet there is no cure for the disease. The majority of existing treatments target motor symptom control. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-3-319-57193-5_3DOI Listing
November 2018
41 Reads

A new potential biomarker for dementia with Lewy bodies: Skin nerve α-synuclein deposits.

Neurology 2017 Jul 30;89(4):318-326. Epub 2017 Jun 30.

From the IRCCS Institute of Neurological Sciences (V.D., A.I., G.R., S.C., R.P., M.S.M., F.M., A.B., R.L.); Department of Biomedical and Neuromotor Sciences (G.R., S.C., R.L.), University of Bologna; Neurological Unit (G. Devigili, R.E.), Department of Neurosciences, "Santa Maria della Misericordia" University Hospital Udine; and Department of Basic Medical Sciences (G. Defazio), Neuroscience and Sense Organs, "Aldo Moro" University of Bari, Italy.

Objective: To investigate whether (1) phosphorylated α-synuclein (p-syn) deposits in skin nerves could be useful in differentiating dementia with Lewy bodies (DLB) from different forms of dementia and (2) small fiber neuropathy (SFN) is associated with DLB.

Methods: We studied 18 well-characterized patients with DLB (11 with autonomic dysfunction), 23 patients with nonsynucleinopathy dementia (NSD; 13 with young-onset Alzheimer disease dementia, 6 frontotemporal dementia, and 4 vascular dementia), and 25 healthy controls. All participants underwent skin biopsies from proximal (i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000004146DOI Listing
July 2017
15 Reads

A multicentre randomiSed controlled TRial of IntraVEnous immunoglobulin compared with standard therapy for the treatment of transverse myelitis in adults and children (STRIVE).

Health Technol Assess 2017 05;21(31):1-50

Department of Children's Neurosciences, Evelina Children's Hospital at Guy's and St Thomas' NHS Foundation Trust, King's Health Partners Academic Health Science Centre, London, UK.

Background: Transverse myelitis (TM) is an immune-mediated disorder of the spinal cord that affects adults and children and that causes motor, sensory and autonomic dysfunction. There is a prolonged recovery phase, which may continue for many years. Neuromyelitis optica (NMO) is an uncommon relapsing inflammatory central nervous system condition in which TM can be the first presenting symptom. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3310/hta21310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512007PMC
May 2017
22 Reads

Interoception and Autonomic Correlates during Social Interactions. Implications for Anorexia.

Front Hum Neurosci 2017 17;11:219. Epub 2017 May 17.

Department of Medicine and Surgery, Unit of Neuroscience, University of ParmaParma, Italy.

The aim of this study is to investigate the bodily-self in Restrictive Anorexia, focusing on two basic aspects related to the bodily self: autonomic strategies in social behavior, in which others' social desirability features, and social cues (e.g., gaze) are modulated, and interoception (i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnhum.2017.00219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434670PMC
May 2017
26 Reads

Viral-mediated oligodendroglial alpha-synuclein expression models multiple system atrophy.

Mov Disord 2017 Aug 29;32(8):1230-1239. Epub 2017 May 29.

Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France.

Background: MSA is a fatal neurodegenerative disorder characterized by a combination of autonomic dysfunction, cerebellar ataxia, and l-dopa unresponsive parkinsonism. The hallmark of MSA is the accumulation of α-synuclein, forming cytoplasmic inclusions in oligodendrocytes. Adeno-associated viruses allow efficient targeting of disease-associated genes in selected cellular ensembles and have proven efficient for the neuronal overexpression of α-synuclein in the substantia nigra in the context of PD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mds.27041DOI Listing
August 2017
37 Reads

Connecting minds and sharing emotions through mimicry: A neurocognitive model of emotional contagion.

Neurosci Biobehav Rev 2017 Sep 12;80:99-114. Epub 2017 May 12.

Leiden University, Institute of Psychology, Cognitive Psychology Unit, Wassenaarseweg 52, Leiden 2333 AK, The Netherlands; Leiden Institute for Brain and Cognition (LIBC), Albinusdreef 2, Leiden 2300 RC, The Netherlands. Electronic address:

During social interactions, people tend to automatically align with, or mimic their interactor's facial expressions, vocalizations, postures and other bodily states. Automatic mimicry might be implicated in empathy and affiliation and is impaired in several pathologies. Despite a growing body of literature on its phenomenology, the function and underlying mechanisms of mimicry remain poorly understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neubiorev.2017.05.013DOI Listing
September 2017
7 Reads

Corticotropin-releasing hormone modulates airway vagal preganglionic neurons of Sprague-Dawley rats at multiple synaptic sites via activation of its type 1 receptors: Implications for stress-associated airway vagal excitation.

Neuroscience 2017 07 10;355:101-112. Epub 2017 May 10.

Department of Neurobiology, School of Basic Medical Sciences, Fudan University, China; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, China. Electronic address:

Corticotropin-releasing hormone release is the final common pathway of stress-associated neuroendocrine responses. This study tested how corticotropin-releasing hormone modulates airway vagal preganglionic neurons. Airway vagal preganglionic neurons in neonatal rats were retrogradely labeled with fluorescent dye and identified in medullary slices, and their responses to corticotropin-releasing hormone (200nmolL) were examined using whole-cell patch clamp. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuroscience.2017.04.049DOI Listing
July 2017
28 Reads
1 Citation
3.360 Impact Factor

Touch between romantic partners: Being stroked is more pleasant than stroking and decelerates heart rate.

Physiol Behav 2017 Aug 3;177:169-175. Epub 2017 May 3.

Dept. of Behavioral Sciences in Medicine, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway.

Introduction: Touch has been found to entail positive effects in the person receiving it, whereas effects on the person giving touch have previously been unexplored. We investigated whether stroking the partner also is a pleasant experience for the person performing it, and whether it has similar effects on well-being and autonomic nervous function as being stroked or stroking oneself. Furthermore, we compared the hedonic and autonomic nervous effects of stroking the partner and self-stroking. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.physbeh.2017.05.006DOI Listing
August 2017
3 Reads

Autonomic Receptor-mediated Regulation of Production and Release of Nitric Oxide in Normal and Malignant Human Urothelial Cells.

Basic Clin Pharmacol Toxicol 2017 Oct 19;121(4):257-265. Epub 2017 Jun 19.

Department of Pharmacology, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

In the urinary bladder, the main source of NO seems to be the urothelium and the underlying suburothelium. In this study, we aimed to characterize how receptors in the human urothelium regulate the production and release of NO. For this, we cultured two human urothelial cell lines - the normal immortalized cell line UROtsa and the malignant cell line T24. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/bcpt.12799
Publisher Site
http://dx.doi.org/10.1111/bcpt.12799DOI Listing
October 2017
3 Reads

Relationship between Cognitive and Sleep-wake Variables in Asymptomatic Offspring of Patients with Late-onset Alzheimer's Disease.

Front Aging Neurosci 2017 5;9:93. Epub 2017 Apr 5.

FLENI Foundation Department of PsychiatryBuenos Aires, Argentina.

Early neuropathological changes characteristic of late-onset Alzheimer's disease (LOAD) involve brain stem and limbic structures that regulate neurovegetative functions, including sleep-wake rhythm. Indeed, sleep pattern is an emerging biomarker and a potential pathophysiological mechanism in LOAD. We hypothesized that cognitively asymptomatic, middle-aged offspring of patients with LOAD (O-LOAD) would display a series of circadian rhythm abnormalities prior to the onset of objective cognitive alterations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnagi.2017.00093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380732PMC
April 2017
3 Reads

Instruction manual for the ILAE 2017 operational classification of seizure types.

Epilepsia 2017 04 8;58(4):531-542. Epub 2017 Mar 8.

The Paediatric Neurosciences Research Group, Royal Hospital for Children, Glasgow, United Kingdom.

This companion paper to the introduction of the International League Against Epilepsy (ILAE) 2017 classification of seizure types provides guidance on how to employ the classification. Illustration of the classification is enacted by tables, a glossary of relevant terms, mapping of old to new terms, suggested abbreviations, and examples. Basic and extended versions of the classification are available, depending on the desired degree of detail. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/epi.13671DOI Listing
April 2017
27 Reads

SCN3A deficiency associated with increased seizure susceptibility.

Neurobiol Dis 2017 Jun 22;102:38-48. Epub 2017 Feb 22.

Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address:

Mutations in voltage-gated sodium channels expressed highly in the brain (SCN1A, SCN2A, SCN3A, and SCN8A) are responsible for an increasing number of epilepsy syndromes. In particular, mutations in the SCN3A gene, encoding the pore-forming Na1.3 α subunit, have been identified in patients with focal epilepsy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nbd.2017.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446790PMC
June 2017
10 Reads

Alterations in cardiac autonomic control in spinal cord injury.

Auton Neurosci 2018 01 15;209:4-18. Epub 2017 Feb 15.

International Collaboration On Repair Discoveries (ICORD), Autonomic Research Unit, ICORD-BSCC, UBC, 818 West 10th Avenue, V5Z 1M9 Vancouver, BC, Canada; Spinal Cord Program, GF Strong Rehabilitation Centre, University of British Columbia, 4255 Laurel St., V5Z 2G9 Vancouver, BC, Canada; Department of Physical Medicine and Rehabilitation, University of Western Ontario, London, ON, Canada. Electronic address:

A spinal cord injury (SCI) interferes with the autonomic nervous system (ANS). The effect on the cardiovascular system will depend on the extent of damage to the spinal/central component of ANS. The cardiac changes are caused by loss of supraspinal sympathetic control and relatively increased parasympathetic cardiac control. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autneu.2017.02.004DOI Listing
January 2018
8 Reads

Changes in sympathetic neurovascular function following spinal cord injury.

Auton Neurosci 2018 01 11;209:25-36. Epub 2017 Feb 11.

Department of Anatomy and Neuroscience, University of Melbourne, Victoria 3010, Australia. Electronic address:

The effects of spinal cord injury (SCI) on sympathetic neurovascular transmission have generally been ignored. This review describes changes in sympathetic nerve-mediated activation of arterial vessels to which ongoing sympathetic activity has been reduced or silenced following spinal cord transection in rats. In all vessels studied in rats, SCI markedly enhanced their contractile responses to nerve activity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autneu.2017.02.003DOI Listing
January 2018
4 Reads

POMC Neurons: From Birth to Death.

Annu Rev Physiol 2017 02;79:209-236

Program in Integrative Cell Signaling and Neurobiology of Metabolism, Yale University School of Medicine, New Haven, Connecticut 06520; email:

The hypothalamus is an evolutionarily conserved brain structure that regulates an organism's basic functions, such as homeostasis and reproduction. Several hypothalamic nuclei and neuronal circuits have been the focus of many studies seeking to understand their role in regulating these basic functions. Within the hypothalamic neuronal populations, the arcuate melanocortin system plays a major role in controlling homeostatic functions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1146/annurev-physiol-022516-034110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669621PMC
February 2017
15 Reads

Brain network alterations in the inflammatory soup animal model of migraine.

Brain Res 2017 04 3;1660:36-46. Epub 2017 Feb 3.

Pain/Analgesia Imaging Neuroscience (P.A.I.N.) Group, Department of Anesthesia, Boston Children's Hospital, Center for Pain and the Brain, Harvard Medical School, Boston, MA, USA; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA; Departments of Psychiatry and Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

Advances in our understanding of the human pain experience have shifted much of the focus of pain research from the periphery to the brain. Current hypotheses suggest that the progression of migraine depends on abnormal functioning of neurons in multiple brain regions. Accordingly, we sought to capture functional brain changes induced by the application of an inflammatory cocktail known as inflammatory soup (IS), to the dura mater across multiple brain networks. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.brainres.2017.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731648PMC
April 2017
4 Reads

The psychosis spectrum in Parkinson disease.

Nat Rev Neurol 2017 Feb 20;13(2):81-95. Epub 2017 Jan 20.

KCL-PARCOG group, Institute of Psychiatry, Psychology &Neuroscience, King's College London, De Crespigny Park, London SE5 8AF, UK.

In 2007, the clinical and research profile of illusions, hallucinations, delusions and related symptoms in Parkinson disease (PD) was raised with the publication of a consensus definition of PD psychosis. Symptoms that were previously deemed benign and clinically insignificant were incorporated into a continuum of severity, leading to the rapid expansion of literature focusing on clinical aspects, mechanisms and treatment. Here, we review this literature and the evolving view of PD psychosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrneurol.2016.200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656278PMC
February 2017
7 Reads

Disruption of Glucagon-Like Peptide 1 Signaling in Sim1 Neurons Reduces Physiological and Behavioral Reactivity to Acute and Chronic Stress.

J Neurosci 2017 01;37(1):184-193

Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, Ohio 45237,

Organismal stress initiates a tightly orchestrated set of responses involving complex physiological and neurocognitive systems. Here, we present evidence for glucagon-like peptide 1 (GLP-1)-mediated paraventricular hypothalamic circuit coordinating the global stress response. The GLP-1 receptor (Glp1r) in mice was knocked down in neurons expressing single-minded 1, a transcription factor abundantly expressed in the paraventricular nucleus (PVN) of the hypothalamus. Read More

View Article

Download full-text PDF

Source
http://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.1104-1
Publisher Site
http://dx.doi.org/10.1523/JNEUROSCI.1104-16.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214629PMC
January 2017
13 Reads

The efficacy of apomorphine - A non-motor perspective.

Parkinsonism Relat Disord 2016 12 9;33 Suppl 1:S28-S35. Epub 2016 Dec 9.

National Parkinson Foundation (NPF) International Center of Excellence at King's College Hospital, London, UK; Dept. Basic and Clinical Neuroscience, The Maurice Wohl Clinical Neuroscience Institute, Institute of Psychology, Psychiatry and Neurosciences, King's College London, UK; National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre, Institute of Psychology, Psychiatry and Neurosciences, King's College London, UK.

Non-motor features have a great impact on progression and quality of life in individuals with Parkinson's disease. Current treatments for PD are limited and apomorphine is one of the advanced therapies available with advantageous effects on motor complications. Several studies have suggested that apomorphine has potential benefits in PD patients beyond its established role in the treatment of motor fluctuations and levodopa-induced dyskinesia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.parkreldis.2016.11.020DOI Listing
December 2016
6 Reads

Cold-induced sympathetic tone modifies the impact of endothelium-dependent vasodilation in the finger pulp.

Auton Neurosci 2017 Mar 30;203:97-102. Epub 2016 Nov 30.

Division of Physiology, Institute of Basic Medical Sciences, University of Oslo, Norway.

Objective: In thermoneutral and cold subjects, the sympathetic nervous system regulates skin blood flow by adjusting frequency of the tonic vasoconstrictor impulses. However, the way these thermoregulatory impulses influence the vascular endothelium is not well known. We studied how the sympathetic nervous system influences endothelium-dependent vasodilation (EDV) caused by shear stress in skin containing arteriovenous anastomoses (AVAs) and arterioles in healthy subjects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autneu.2016.11.004DOI Listing
March 2017
5 Reads

Neural connection supporting endogenous 5-hydroxytryptamine influence on autonomic activity in medial prefrontal cortex.

Auton Neurosci 2017 Mar 1;203:25-32. Epub 2016 Dec 1.

Department of Anatomy and K.K. Leung Brain Research Centre, The Fourth Military Medical University, Xi'an, People's Republic of China. Electronic address:

5-hydroxytryptamine (5-HT) transmission in the medial prefrontal cortex (mPFC) enhances or suppresses signal outflow to influence emotion-/cognition-based function performances and, putatively, the autonomic responses. The top-down cortical modulation of autonomic activities may be mediated in part through projections from mPFC to brain stem dorsal vagal complex (DVC). The abundant and heterogeneous densities of 5-HT fibers across laminae in mPFC suggest serotonergic innervation of mPFC-DVC projection neurons whereby endogenous 5-HT acts to regulate autonomic activities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autneu.2016.11.005DOI Listing
March 2017
11 Reads

Basics of neuroanatomy and neurophysiology.

Handb Clin Neurol 2016 ;138:53-68

Aging, Mobility, and Cognitive Neuroscience Laboratory, Department of Physical Therapy, Faculty of Medicine and Djavad Mowafaghian Centre for Brain Health, University of British Columbia Vancouver, BC, Canada; Brain Research Centre, University of British Columbia Vancouver, BC, Canada. Electronic address:

This chapter presents an overview of the anatomy and functioning of the central nervous system. We begin the discussion by first examining the cellular basis of neural transmission. Then we present a brief description of the brain's white and gray matter and associated diseases, including a discussion of white-matter lesions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/B978-0-12-802973-2.00004-5DOI Listing
March 2017
2 Reads

A New Folding Kinetic Mechanism for Human Transthyretin and the Influence of the Amyloidogenic V30M Mutation.

Int J Mol Sci 2016 Aug 31;17(9). Epub 2016 Aug 31.

Chemistry Department and Coimbra Chemistry Centre, Faculty of Science and Technology, University of Coimbra, Coimbra 3004-535, Portugal.

Protein aggregation into insoluble amyloid fibrils is the hallmark of several neurodegenerative diseases, chief among them Alzheimer's and Parkinson's. Although caused by different proteins, these pathologies share some basic molecular mechanisms with familial amyloidotic polyneuropathy (FAP), a rare hereditary neuropathy caused by amyloid formation and deposition by transthyretin (TTR) in the peripheral and autonomic nervous systems. Among the amyloidogenic TTR mutations known, V30M-TTR is the most common in FAP. Read More

View Article

Download full-text PDF

Source
http://www.mdpi.com/1422-0067/17/9/1428
Publisher Site
http://dx.doi.org/10.3390/ijms17091428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037707PMC
August 2016
6 Reads

Characterization of the intrinsic cardiac nervous system.

Auton Neurosci 2016 08 6;199:3-16. Epub 2016 Aug 6.

Department of Cardiovascular Sciences, Cardiology Group, Glenfield Hospital, Groby Road, University of Leicester, LE3 9QP, United Kingdom; Leicester NIHR Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester LE3 9QP, United Kingdom. Electronic address:

Heart disease is the number one cause of mortality in the developed world and it is well recognised that neural mechanisms are important in pathology. As well as peripheral autonomic nerves, there is a rich intrinsic innervation of the heart that includes cardiac ganglia, collectively termed ganglionic plexuses (GP). Understanding the role that the intrinsic cardiac nervous system (ICNS) play in controlling cardiac function and how it interacts with information between central command centers and its integration with sensory information from the myocardium could prove crucial for prophylactic and corrective treatments of heart disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autneu.2016.08.006DOI Listing
August 2016
4 Reads

The sympathetic innervation of the heart: Important new insights.

Auton Neurosci 2016 08 24;199:17-23. Epub 2016 Aug 24.

Cardiovascular Sciences, Glenfield Hospital, University of Leicester, UK.

Autonomic control of the heart has a significant influence over development of life threatening arrhythmias that can lead to sudden cardiac death. Sympathetic activity is known to be upregulated during these conditions and hence the sympathetic nerves present a target for treatment. However, a better understanding of the anatomy and physiology of cardiac sympathetic nerves is required for the progression of clinical interventions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autneu.2016.08.014DOI Listing
August 2016
4 Reads

Non-Motor Symptoms in Patients Suffering from Motor Neuron Diseases.

Front Neurol 2016 25;7:117. Epub 2016 Jul 25.

Department of Neurology, Division for Neurodegenerative Diseases, Technische Universität Dresden, Dresden, Germany; German Center for Neurodegenerative Diseases (DZNE) Dresden, Dresden, Germany.

Background: The recently postulated "disease spreading hypothesis" has gained much attention, especially for Parkinson's disease (PD). The various non-motor symptoms (NMS) in neurodegenerative diseases would be much better explained by this hypothesis than by the degeneration of disease-specific cell populations. Motor neuron disease (MND) is primarily known as a group of diseases with a selective loss of motor function. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fneur.2016.00117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958907PMC
August 2016
7 Reads