212 results match your criteria Autonomic Neuroscience: Basic & Clinical [Journal]


The microstructure of REM sleep: Why phasic and tonic?

Sleep Med Rev 2020 Mar 19;52:101305. Epub 2020 Mar 19.

UR2NF, Neuropsychology and Functional Neuroimaging Research Unit at CRCN - Center for Research in Cognition and Neurosciences and UNI - ULB Neurosciences Institute, Université Libre de Bruxelles (ULB), Brussels, Belgium.

Rapid eye movement (REM) sleep is a peculiar neural state that occupies 20-25% of nighttime sleep in healthy human adults and seems to play critical roles in a variety of functions spanning from basic physiological mechanisms to complex cognitive processes. REM sleep exhibits a plethora of transient neurophysiological features, such as eye movements, muscle twitches, and changes in autonomic activity, however, despite its heterogeneous nature, it is usually conceptualized as a homogeneous sleep state. We propose here that differentiating and exploring the fine microstructure of REM sleep, especially its phasic and tonic constituents would provide a novel framework to examine the mechanisms and putative functions of REM sleep. Read More

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http://dx.doi.org/10.1016/j.smrv.2020.101305DOI Listing

The role of tissue biopsy as a biomarker in REM sleep behavior disorder.

Sleep Med Rev 2020 Jun 11;51:101283. Epub 2020 Feb 11.

Department of Neurology & Neurological Sciences, Stanford University, Palo Alto, CA, USA. Electronic address:

Patients with idiopathic REM-sleep behavior disorder (iRBD) are at substantial risk of progressive neurodegenerative disease of α-synuclein pathology. Longitudinal studies have demonstrated that abnormal α-synuclein deposition occurs early in the course of disease and may precede the appearance of motor symptoms by several decades. This provides rationale for the use of a reliable biomarker to both follow disease progression and to assess treatment response, once disease-modifying treatments become available. Read More

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http://dx.doi.org/10.1016/j.smrv.2020.101283DOI Listing

Efficacy of transcutaneous electrical acupoint stimulation combined with general anesthesia for sedation and postoperative analgesia in minimally invasive lung cancer surgery: A randomized, double-blind, placebo-controlled trial.

Thorac Cancer 2020 Apr 16;11(4):928-934. Epub 2020 Feb 16.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Anesthesiology, Peking University Cancer Hospital and Institute, Beijing, China.

Background: Multimodal opioid-sparing analgesia is a key component of an enhanced recovery pathway after surgery that aims to improve postoperative recovery. Transcutaneous electrical acupoint stimulation (TEAS) is assumed to alleviate pain and anxiety and to modify the autonomic nervous system. This study aimed to determine the efficacy of TEAS for sedation and postoperative analgesia in lung cancer patients undergoing thoracoscopic pulmonary resection. Read More

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http://dx.doi.org/10.1111/1759-7714.13343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113057PMC
April 2020
1.126 Impact Factor

Emotion-body connection dispositions modify the insulae-midcingulate effective connectivity during anger processing.

PLoS One 2020 13;15(2):e0228404. Epub 2020 Feb 13.

Department of Psychiatry, Liaison Psychiatry, University Hospitals of Geneva, Geneva, Switzerland.

The link between anger and bodily states is readily apparent based on the autonomic and behavioral responses elicited. In everyday life angry people react in different ways, from being agitated with an increased heart rate to remaining silent or detached. Neuroimaging evidence supports the role of mid-posterior insula and midcingulate cortex/MCC as key nodes of a sensorimotor network that predominantly responds to salient stimuli, integration of interoceptive and autonomic information, as well as to awareness of bodily movements for coordinated motion. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0228404PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018059PMC

SCN8A heterozygous variants are associated with anoxic-epileptic seizures.

Am J Med Genet A 2020 05 10;182(5):1209-1216. Epub 2020 Feb 10.

Pediatric Neurology Unit, Child and Adolescent Department, Geneva University Hospitals, Geneva, Switzerland.

Anoxic-epileptic seizures (AES) are rare outcomes of common childhood reflex anoxic syncope that trigger a true epileptic seizure. The term AES was coined by Stephenson in 1983, to differentiate these events from convulsive syncopes and the more common reflex anoxic syncopes. A genetic susceptibility for AES has been postulated; but, its molecular basis has up to now been elusive. Read More

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http://dx.doi.org/10.1002/ajmg.a.61513DOI Listing

Severing the ventral funiculus in chronic spinal cord injury has the most deteriorating effect on spermatogenesis in rats.

Auton Neurosci 2020 03 17;224:102639. Epub 2020 Jan 17.

Department of Public Health Medicine, Faculty of Medicine, University of Pécs, Baranya, Hungary.

Sexual dysfunction, following spinal cord injury (SCI), is highly dependent on the extent of injury. SCI disrupts the supraspinal innervation of the reproductive organs; resulting in structural and functional deficits. Relating the extent of SCI to these changes could eventually improve diagnoses and treatment planning of sexual dysfunction following SCI. Read More

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http://dx.doi.org/10.1016/j.autneu.2020.102639DOI Listing

The mere physical presence of another person reduces human autonomic responses to aversive sounds.

Proc Biol Sci 2020 01 22;287(1919):20192241. Epub 2020 Jan 22.

Center of Mental Health, Department of Psychiatry, Psychosomatic and Psychotherapy, Translational Social Neuroscience Unit, University of Wurzburg, Wurzburg 97080, Germany.

Social animals show reduced physiological responses to aversive events if a conspecific is physically present. Although humans are innately social, it is unclear whether the mere physical presence of another person is sufficient to reduce human autonomic responses to aversive events. In our study, participants experienced aversive and neutral sounds alone (alone treatment) or with an unknown person that was physically present without providing active support. Read More

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http://dx.doi.org/10.1098/rspb.2019.2241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015327PMC
January 2020

FAM134B oligomerization drives endoplasmic reticulum membrane scission for ER-phagy.

EMBO J 2020 Mar 13;39(5):e102608. Epub 2020 Jan 13.

Department of Biochemistry, Department of Cardiology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Degradation of endoplasmic reticulum (ER) by selective autophagy (ER-phagy) is crucial for ER homeostasis. However, it remains unclear how ER scission is regulated for subsequent autophagosomal sequestration and lysosomal degradation. Here, we show that oligomerization of ER-phagy receptor FAM134B (also referred to as reticulophagy regulator 1 or RETREG1) through its reticulon-homology domain is required for membrane fragmentation in vitro and ER-phagy in vivo. Read More

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http://dx.doi.org/10.15252/embj.2019102608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049798PMC

Activation of bradykinin-sensitive pericardial afferents increases systemic venous tone in conscious rats.

Auton Neurosci 2020 01 26;223:102624. Epub 2019 Dec 26.

Division of Basic Biomedical Sciences, Sanford School of Medicine University of South Dakota, 414 East Clark Street, Vermillion, SD 57069, United States of America.

Our understanding of reflex regulation of veins lags behind that of the arterial system. While the cardiac sympathetic afferent reflex (CSAR) exerts control over sympathetic outflow, its effect on venous tone is not known. We tested the hypothesis that activation of pericardial bradykinin sensitive afferents elicits systemic venoconstriction. Read More

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http://dx.doi.org/10.1016/j.autneu.2019.102624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017472PMC
January 2020

Biochemical Modulation and Pathophysiology of Migraine.

J Neuroophthalmol 2019 12;39(4):470-479

Headache Group, Department of Basic and Clinical Neuroscience (CC, DYW, PJG), Institute of Psychology, Psychiatry and Neuroscience, King's College London, London, United Kingdom; and NIHR-Wellcome Trust King's Clinical Research Facility (CC, DYW, PJG), SLaM Biomedical Research Centre, King's College Hospital, London, United Kingdom.

Background: Migraine is a common disabling neurological disorder where attacks have been recognized to consist of more than headache. The premonitory, headache, and postdromal phases are the various phases of the migraine cycle, where aura can occur before, during, or after the onset of pain. Migraine is also associated with photosensitivity and cranial autonomic symptoms, which includes lacrimation, conjunctival injection, periorbital edema, ptosis, nasal congestion, and rhinorrhoea. Read More

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http://dx.doi.org/10.1097/WNO.0000000000000875DOI Listing
December 2019

The Concept of Neuroglia.

Adv Exp Med Biol 2019 ;1175:1-13

Department of Neurobiology, The University of Alabama at Birmingham, Birmingham, AL, USA.

Neuroglia represent a diverse population of non-neuronal cells in the nervous systems, be that peripheral, central, enteric or autonomic nervous system. Arguably, these cells represent about half of the volume of the human brain. This volumetric ratio, and by extension glia to neurone ratio, not only widely differ depending on the size of the animal species brain and its positioning on the phylogenetic tree, but also vary between the regions of an individual brain. Read More

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http://dx.doi.org/10.1007/978-981-13-9913-8_1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188601PMC
October 2019

Corrigendum to "Role of P2X3 receptor in myocardial ischemia injury and nociceptive sensory transmission" [Auton. Neurosci.: Basic Clin. volume 139, (issues 1-2), (30 May 2008), pages 30-37].

Auton Neurosci 2019 Nov 5;221:102587. Epub 2019 Sep 5.

Department of Physiology, Medical College of Nanchang University, Nanchang, Jiangxi 330006, PR China.

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http://dx.doi.org/10.1016/j.autneu.2019.102587DOI Listing
November 2019
1 Read

Extensive Inhibitory Gating of Viscerosensory Signals by a Sparse Network of Somatostatin Neurons.

J Neurosci 2019 10 30;39(41):8038-8050. Epub 2019 Aug 30.

Florey Institute of Neuroscience and Mental Health, and

Integration and modulation of primary afferent sensory information begins at the first terminating sites within the CNS, where central inhibitory circuits play an integral role. Viscerosensory information is conveyed to the nucleus of the solitary tract (NTS) where it initiates neuroendocrine, behavioral, and autonomic reflex responses that ensure optimal internal organ function. This excitatory input is modulated by diverse, local inhibitory interneurons, whose functions are not clearly understood. Read More

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http://dx.doi.org/10.1523/JNEUROSCI.3036-18.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786816PMC
October 2019
4 Reads

Symbolic analysis of heart rate fluctuations identifies cardiac autonomic modifications during LPS-induced endotoxemia.

Auton Neurosci 2019 11 16;221:102577. Epub 2019 Jul 16.

Metropolitan Autonomous University (UAM), Campus Lerma, Biological and Health Sciences Division, Lerma 52005, Mexico; Swiss Federal Institute of Technology (ETH) Zurich, Department of Health Sciences, and Technology, Zurich 8092, Switzerland. Electronic address:

The present study aimed to compare linear and symbolic dynamics (SD) indices for detecting the autonomic cardiac changes produced by endotoxemia in freely-moving rats. In this context, we analyzed ECG-derived R-R time series in freely moving Dark Agouti rats, which received lipopolysaccharide (LPS, n = 9), or vehicle (V, n = 7). Five minutes R-R time series were assessed every hour up to +12 h and + 24 h post-LPS injection. Read More

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http://dx.doi.org/10.1016/j.autneu.2019.102577DOI Listing
November 2019
1 Read

The effects of mindfulness training on competition-induced anxiety and salivary stress markers in elite Wushu athletes: A pilot study.

Physiol Behav 2019 10 19;210:112655. Epub 2019 Aug 19.

Department of Psychology, Faculty of Psychology and Education, University of Tehran, Tehran, Iran. Electronic address:

Objective: Due to the impact of stress and related psychophysiological responses on competitive performance, psychological interventions that reduce stress and may thus increase athletic performance need to be evaluated. In this pilot study, the effects of a mindfulness-based intervention (MBI) on competitive anxiety, self-confidence and mindfulness, and autonomic and endocrine stress responses to a competition in elite athletes were explored.

Methods: Twenty-six male elite Wushu athletes (N = 26) were randomly assigned to either MBI (8 weeks) or a wait-list control group. Read More

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http://dx.doi.org/10.1016/j.physbeh.2019.112655DOI Listing
October 2019
4 Reads

Managing cluster headache.

Pract Neurol 2019 Dec 5;19(6):521-528. Epub 2019 Jul 5.

Headache Group, Department of Basic and Clinical Neuroscience, King's College London, London, UK

Cluster headache is a neurological disorder that presents with unilateral severe headache associated with ipsilateral cranial autonomic symptoms. Cluster headache attacks often occur more than once a day, and typically manifesting in bouts. It has a point prevalence of 1 in 1000 and is the most common trigeminal autonomic cephalalgia. Read More

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http://dx.doi.org/10.1136/practneurol-2018-002124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902063PMC
December 2019
8 Reads

Cluster Headache in Kuwait: A Hospital-Based Study.

Front Neurol 2019 4;10:573. Epub 2019 Jun 4.

Department of Basic and Clinical Neuroscience, Headache Group, Institute of Psychiatry, Psychology and Neuroscience, King's College London, NIHR-Wellcome Trust King's Clinical Research Facility, King's College Hospital, London, United Kingdom.

Cluster headache (CH) is a relatively uncommon primary headache disorder. Few studies in our region described CH. We aimed to study demographics, clinical characteristics and treatment modalities of CH patients referred to Headache Clinic in Kuwait. Read More

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http://dx.doi.org/10.3389/fneur.2019.00573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558162PMC
June 2019
15 Reads

Trigeminal autonomic cephalalgias presenting in a multidisciplinary tertiary orofacial pain clinic.

J Headache Pain 2019 Jun 11;20(1):69. Epub 2019 Jun 11.

Headache Group, Department of Basic and Clinical Neuroscience, King's College London, London, UK.

Orofacial pain may have a variety of causes and offers a significant clinical challenge for its diagnosis and management.

Objective: To assess the headache disorders presenting in a tertiary multidisciplinary orofacial pain clinic, after dental causes have been excluded.

Methods: Clinic letters from the initial consultation and subsequent follow up reviews of the 142 patients, who were seen in the tertiary Multidisciplinary Orofacial Pain clinic between January 2015 until January 2018 were reviewed as a clinical audit. Read More

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http://dx.doi.org/10.1186/s10194-019-1019-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734481PMC
June 2019
4 Reads

Spatiotemporal structure of cell fate decisions in murine neural crest.

Science 2019 Jun;364(6444)

Department of Molecular Neurosciences, Center for Brain Research, Medical University Vienna, 1090 Vienna, Austria.

Neural crest cells are embryonic progenitors that generate numerous cell types in vertebrates. With single-cell analysis, we show that mouse trunk neural crest cells become biased toward neuronal lineages when they delaminate from the neural tube, whereas cranial neural crest cells acquire ectomesenchyme potential dependent on activation of the transcription factor The choices that neural crest cells make to become sensory, glial, autonomic, or mesenchymal cells can be formalized as a series of sequential binary decisions. Each branch of the decision tree involves initial coactivation of bipotential properties followed by gradual shifts toward commitment. Read More

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http://dx.doi.org/10.1126/science.aas9536DOI Listing
June 2019
9 Reads
31.477 Impact Factor

Nurturescience versus neuroscience: A case for rethinking perinatal mother-infant behaviors and relationship.

Birth Defects Res 2019 09 30;111(15):1110-1127. Epub 2019 May 30.

Department of Pediatrics, Columbia University Irving Medical Center, New York, New York.

Behavioral and emotional outcomes for babies who experienced maternal separation due to prematurity or birth defects have not improved significantly for the last 20 years. Current theories and treatment paradigms based on neuroscience have not generated explanatory mechanisms that work, or provided testable hypotheses. This article proposes a new field of scientific investigation, "nurturescience" within which new hypotheses can be tested with novel instruments. Read More

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http://dx.doi.org/10.1002/bdr2.1529DOI Listing
September 2019
20 Reads

Cognitive self-regulation influences pain-related physiology.

Pain 2019 10;160(10):2338-2349

Department of Psychology and Neuroscience, University of Colorado, Boulder, CO, United States.

Cognitive self-regulation can shape pain experience, but its effects on autonomic responses to painful events are unclear. In this study, participants (N = 41) deployed a cognitive strategy based on reappraisal and imagination to regulate pain up or down on different trials while skin conductance responses (SCRs) and electrocardiogram activity were recorded. Using a machine learning approach, we first developed stimulus-locked SCR and electrocardiogram physiological markers predictive of pain ratings. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001621DOI Listing
October 2019
8 Reads

New basic insights on the potential of a chitosan-based medical device for improving functional recovery after radical prostatectomy.

BJU Int 2019 12 27;124(6):1063-1076. Epub 2019 Jun 27.

Department of Clinical and Biological Sciences, Cavalieri Ottolenghi Neuroscience Institute, University of Turin, Orbassano, Italy.

Objectives: To evaluate: (i) the neuro-regenerative potential of chitosan membrane (CS-Me) on acutely axotomised autonomic neurones in vitro; (ii) to exclude the possibility that a pro-regenerative biomaterial could interfere with the proliferation activity of prostate cancer cell lines; (iii) to provide an in vivo proof of the biocompatibility and regeneration promoting effect of CS-Me in a standardised rat model of peripheral nerve injury and repair; (iv) finally, to evaluate the tissue reaction induced by the degrading material; as previous studies have shown promising effects of CS-Me for protection of the neurovascular bundles for potency recovery in patients that undergo nerve-sparing radical prostatectomy (RP).

Materials And Methods: Addressing aim (i), the neuro-regenerative potential, organotypic cultures derived from primary sympathetic ganglia were cultured on CS-Me over 3 days and neurite extension and axonal sprouting were evaluated. Addressing aim (ii), effects of CS on cancer cells, different human prostate cancer cell lines (PC3, DU-145, LN-Cap) were seeded on CS-coated plates or cultured in the presence of CS-Me dissolution products. Read More

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http://dx.doi.org/10.1111/bju.14834DOI Listing
December 2019
3 Reads

Exploring hyperhidrosis and related thermoregulatory symptoms as a possible clinical identifier for the dysautonomic subtype of Parkinson's disease.

J Neurol 2019 Jul 17;266(7):1736-1742. Epub 2019 Apr 17.

King's College London, Institute of Psychiatry, Psychology and Neuroscience, Department of Basic and Clinical Neurosciences, De Crespigny Park, London, SE5 8AF, UK.

Objective: To identify associated (non-)motor profiles of Parkinson's disease (PD) patients with hyperhidrosis as a dominant problem.

Methods: This is a cross-sectional, exploratory, analysis of participants enrolled in the Non-motor Longitudinal International Study (NILS; UKCRN No: 10084) at the Parkinson's Centre at King's College Hospital (London, UK). Hyperhidrosis scores (yes/no) on question 28 of the Non-Motor Symptom Questionnaire were used to classify patients with normal sweat function (n = 172) and excessive sweating (n = 56) (Analysis 1; n = 228). Read More

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http://dx.doi.org/10.1007/s00415-019-09325-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586713PMC
July 2019
13 Reads

Noise exposure accelerates the risk of cognitive impairment and Alzheimer's disease: Adulthood, gestational, and prenatal mechanistic evidence from animal studies.

Neurosci Biobehav Rev 2019 Apr 9. Epub 2019 Apr 9.

Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, T1K 3M4, Canada. Electronic address:

This review examines the adverse impacts of different noise exposure paradigms on the neuroendocrine system, hippocampal and neocortical structures, cognitive performances, and the development of Alzheimer's disease (AD)-like neuropathological changes in the brain of laboratory animals. Studies were reviewed in three periods during the lifespan including: adult animals exposed to noise, female rodents exposed to noise during gestation, and offspring exposed to noise during the prenatal period. Findings imply that chronic noise exposure dysregulates the neuroendocrine system leading to hyperactivation of the sympathetic divisions of the autonomic nervous system (i. Read More

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http://dx.doi.org/10.1016/j.neubiorev.2019.04.001DOI Listing
April 2019
26 Reads

EEG and ANS markers of attention response in vegetative state: Different responses to own vs. other names.

Neuropsychol Rehabil 2019 Mar 27:1-19. Epub 2019 Mar 27.

a Research Unit in Affective and Social Neuroscience , Catholic University of the Sacred Heart , Milano , Italy.

Covert measures of information-processing are valuable tools to support assessment of patients' disorders of consciousness because of their potential in revealing what seem to be hidden. Those measures allow to overcome some limitations of traditional behavioural methods, which are often biased by difficulties in detecting reliable patients' responses. Therefore, we aimed at exploring patterns of psychophysiological responses (electroencephalography - EEG, skin conductance level - SCL, skin conductance response - SCR, heart rate - HR) marking potentially-preserved processing of personally-relevant stimuli in a sample of VS patients. Read More

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http://dx.doi.org/10.1080/09602011.2019.1595020DOI Listing
March 2019
2 Reads

Impairments in cognitive performance in chronic fatigue syndrome are common, not related to co-morbid depression but do associate with autonomic dysfunction.

PLoS One 2019 5;14(2):e0210394. Epub 2019 Feb 5.

Institute of Cellular Medicine, Newcastle University, Newcastle, United Kingdom.

Objectives: To explore cognitive performance in chronic fatigue syndrome (CFS) examining two cohorts. To establish findings associated with CFS and those related to co-morbid depression or autonomic dysfunction.

Methods: Identification and recruitment of participants was identical in both phases, all CFS patients fulfilled Fukuda criteria. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210394PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363139PMC
October 2019
4 Reads

Augmentation of Whole-Body Metabolic Status by Mind-Body Training: Synchronous Integration of Tissue- and Organ-Specific Mitochondrial Function.

Med Sci Monit Basic Res 2019 Jan 11;25:8-14. Epub 2019 Jan 11.

Department of Psychiatry, First Faculty of Medicine Charles University in Prague and General University Hospital in Prague, Center for Cognitive and Molecular Neuroscience, Prague, Czech Republic.

The objective of our concise review is to elaborate an evidence-based integrative medicine model that incorporates functional linkages of key aspects of cortically-driven mind-body training procedures to biochemical and molecular processes driving enhanced cellular bioenergetics and whole-body metabolic advantage. This entails the adoption of a unified biological systems approach to selectively elucidate basic biochemical and molecular events responsible for achieving physiological relaxation of complex cellular structures. We provide accumulated evidence in support of the potential synergy of voluntary breathing exercises in combination with meditation and/or complementary cognitive tasks to promote medically beneficial enhancements in whole-body relaxation, anti-stress mechanisms, and restorative sleep. Read More

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https://basic.medscimonit.com/abstract/index/idArt/913264
Publisher Site
http://dx.doi.org/10.12659/MSMBR.913264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505060PMC
January 2019
23 Reads

Interaction Between Stress and Addiction: Contributions From Latin-American Neuroscience.

Front Psychol 2018 21;9:2639. Epub 2018 Dec 21.

Neuroscience Research Group, Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia.

Drug addiction is a chronic neuropsychiatric disorder that escalates from an initial exposure to drugs of abuse, such as cocaine, cannabis, or heroin, to compulsive drug-seeking and intake, reduced ability to inhibit craving-induced behaviors, and repeated cycles of abstinence and relapse. It is well-known that chronic changes in the brain's reward system play an important role in the neurobiology of addiction. Notably, environmental factors such as acute or chronic stress affect this system, and increase the risk for drug consumption and relapse. Read More

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https://www.frontiersin.org/article/10.3389/fpsyg.2018.02639
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http://dx.doi.org/10.3389/fpsyg.2018.02639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308142PMC
December 2018
17 Reads

A novel nonsense mutation in WNK1/HSN2 associated with sensory neuropathy and limb destruction in four siblings of a large Iranian pedigree.

BMC Neurol 2018 Nov 29;18(1):195. Epub 2018 Nov 29.

Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Hereditary sensory and autonomic neuropathy type 2 (HSAN2) is an autosomal recessive disorder with predominant sensory dysfunction and severe complications such as limb destruction. There are different subtypes of HSAN2, including HSAN2A, which is caused by mutations in WNK1/HSN2 gene.

Methods: An Iranian family with four siblings and autosomal recessive inheritance pattern whom initially diagnosed with HSAN2 underwent whole exome sequencing (WES) followed by segregation analysis. Read More

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http://dx.doi.org/10.1186/s12883-018-1201-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262971PMC
November 2018
9 Reads

Classical paintings may trigger pain and pleasure in the gendered brain.

Cortex 2018 12 28;109:171-180. Epub 2018 Sep 28.

Brain and Emotion Laboratory, Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, the Netherlands.

The human body is the most common object of pictorial representation in western art and its representations trigger a vast range of experiences from pain to pleasure. The goal of this study was to investigate brain activity triggered by paintings of male and female body images exemplifying conditions associated with pleasure or pain. Our findings show participant-general as well as gender specific brain activity for either the pain or the pleasure conditions. Read More

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http://dx.doi.org/10.1016/j.cortex.2018.09.011DOI Listing
December 2018
5 Reads

EEG and autonomic responses to nociceptive stimulation in disorders of consciousness.

J Clin Neurosci 2019 Feb 9;60:101-106. Epub 2018 Oct 9.

Research Unit in Affective and Social Neuroscience, Catholic University of the Sacred Heart, Milano, Italy; Department of Psychology, Catholic University of the Sacred Heart, Milano, Italy.

Since behavioral responses to external stimuli of patients presenting disorders of consciousness (DoC) are often difficult to qualify, covert physiological correlates of responsivity are deemed as potentially valuable tools to help assessment procedures. While noxious stimuli seem good candidates to explore DoC patients' responsivity, autonomic and electrophysiological correlates of pain detection in DoC patients are still debated. This research aims at investigating autonomic and cortical activation as covert measure of residual somatosensory and nociceptive processes in patients in vegetative state. Read More

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http://dx.doi.org/10.1016/j.jocn.2018.09.020DOI Listing
February 2019
3 Reads

The sympathetic nervous system regulates skeletal muscle motor innervation and acetylcholine receptor stability.

Acta Physiol (Oxf) 2019 03 22;225(3):e13195. Epub 2018 Oct 22.

Department of Internal Medicine, Gerontology, Wake Forest School of Medicine, Winston-Salem, North Carolina.

Aim: Symptoms of autonomic failure are frequently the presentation of advanced age and neurodegenerative diseases that impair adaptation to common physiologic stressors. The aim of this work was to examine the interaction between the sympathetic and motor nervous system, the involvement of the sympathetic nervous system (SNS) in neuromuscular junction (NMJ) presynaptic motor function, the stability of postsynaptic molecular organization, and the skeletal muscle composition and function.

Methods: Since muscle weakness is a symptom of diseases characterized by autonomic dysfunction, we studied the impact of regional sympathetic ablation on muscle motor innervation by using transcriptome analysis, retrograde tracing of the sympathetic outflow to the skeletal muscle, confocal and electron microscopy, NMJ transmission by electrophysiological methods, protein analysis, and state of the art microsurgical techniques, in C57BL6, MuRF1KO and Thy-1 mice. Read More

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http://doi.wiley.com/10.1111/apha.13195
Publisher Site
http://dx.doi.org/10.1111/apha.13195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224611PMC
March 2019
15 Reads
4.382 Impact Factor

Development of a Novel FIJI-Based Method to Investigate Neuronal Circuitry in Neonatal Mice.

Dev Neurobiol 2018 11 20;78(11):1146-1167. Epub 2018 Sep 20.

Department of Pathology, Division of Neuropathology, The Ohio State University College of Medicine, Columbus, Ohio.

The emergence of systems neuroscience tools requires parallel generation of objective analytical workflows for experimental neuropathology. We developed an objective analytical workflow that we used to determine how specific autonomic neural lineages change during postnatal development. While a wealth of knowledge exists regarding postnatal alterations in respiratory neural function, how these neural circuits change and develop in the weeks following birth remains less clear. Read More

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http://dx.doi.org/10.1002/dneu.22636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391728PMC
November 2018
31 Reads

Neurophysiological correlates of clinical improvement after greater occipital nerve (GON) block in chronic migraine: relevance for chronic migraine pathophysiology.

J Headache Pain 2018 Aug 20;19(1):73. Epub 2018 Aug 20.

Headache Centre & Neurocritical Care Unit. Department of Human Neurosciences, Sapienza - University of Rome, Viale dell'Università 30, 00185, Rome, Italy.

Background: Therapeutic management of Chronic Migraine (CM), often associated with Medication Overuse Headache (MOH), is chiefly empirical, as no biomarker predicting or correlating with clinical efficacy is available to address therapeutic choices. The present study searched for neurophysiological correlates of Greater Occipital Nerve Block (GON-B) effects in CM.

Methods: We recruited 17 CM women, of whom 12 with MOH, and 19 healthy volunteers (HV). Read More

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http://dx.doi.org/10.1186/s10194-018-0901-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102162PMC
August 2018
44 Reads

Role of microglia M1/M2 polarisation in the paraventricular nucleus: New insight into the development of stress-induced hypertension in rats.

Auton Neurosci 2018 09 12;213:71-80. Epub 2018 Jun 12.

School of Life Sciences, Shanghai University, 333 Nanchen Road, Shanghai 200444, PR China. Electronic address:

The lack of precise therapies for stress-induced hypertension highlights the need to explore the process of blood pressure changes. Studies have shown that neuroinflammation in the central nervous system is associated with hypertension, although the mechanisms remain elusive. Microglia, are known to play dualistic protective and destructive roles, representing logical but challenging targets for improving stress-induced hypertension. Read More

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http://dx.doi.org/10.1016/j.autneu.2018.06.003DOI Listing
September 2018
16 Reads

Brain structure and function related to headache: Brainstem structure and function in headache.

Cephalalgia 2019 11 3;39(13):1635-1660. Epub 2018 Jul 3.

Department of Neural and Pain Sciences, University of Maryland Baltimore, Baltimore, MD, USA.

Objective: To review and discuss the literature relevant to the role of brainstem structure and function in headache.

Background: Primary headache disorders, such as migraine and cluster headache, are considered disorders of the brain. As well as head-related pain, these headache disorders are also associated with other neurological symptoms, such as those related to sensory, homeostatic, autonomic, cognitive and affective processing that can all occur before, during or even after headache has ceased. Read More

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http://dx.doi.org/10.1177/0333102418784698DOI Listing
November 2019
17 Reads

A detailed clinical study of pain in 1957 participants with early/moderate Parkinson's disease.

Parkinsonism Relat Disord 2018 11 6;56:27-32. Epub 2018 Jun 6.

Department of Neurology, Institute of Neurological Sciences, Queen Elizabeth University Hospital, Glasgow, United Kingdom.

Introduction: The causes of pain in early/moderate Parkinson's disease (PD) are not well understood. Although peripheral factors such as rigidity, reduced joint movements and poor posture may contribute towards the development of pain, central mechanisms including altered nociceptive processing may also be involved.

Methods: We performed a large clinical study to investigate potential factors contributing towards pain in early/moderate PD. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2018.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302227PMC
November 2018
10 Reads

The Role of the Periaqueductal Gray Matter in Lower Urinary Tract Function.

Mol Neurobiol 2019 Feb 26;56(2):920-934. Epub 2018 May 26.

Department of Urology, Maastricht University Medical Center, Maastricht, The Netherlands.

The periaqueductal gray matter (PAG), as one of the mostly preserved evolutionary components of the brain, is an axial structure modulating various important functions of the organism, including autonomic, behavioral, pain, and micturition control. It has a critical role in urinary bladder physiology, with respect to storage and voiding of urine. The PAG has a columnar composition and has extensive connections with its cranially and caudally located components of the central nervous system (CNS). Read More

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http://dx.doi.org/10.1007/s12035-018-1131-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400878PMC
February 2019
43 Reads
5.137 Impact Factor

Time-dependent changes in cardiorespiratory functions of anesthetized rats exposed to sustained hypoxia.

Auton Neurosci 2018 07 14;212:1-9. Epub 2018 Mar 14.

Laboratory of Veterinary Anatomy and Cell Biology, Faculty of Agriculture, Iwate University, 18-8, Ueda 3-chome, Morioka, Iwate 020-8550, Japan; Department of Basic Veterinary Science, United Graduate School of Veterinary Science, Gifu University, 1-1, Yanagido, Gifu 501-1193, Japan. Electronic address:

Although cardiovascular responses may be altered by respiratory changes under prolonged hypoxia, the relationship between respiratory and cardiovascular changes remains unknown. The aim of the present study is to clarify cardiorespiratory changes in anesthetized rats during and after hypoxic conditions using simultaneous recordings of cardiorespiratory variables with 20-sec recording intervals. After air breathing for 20 min (pre-exposure period), rats were subjected to 10% O for 2 h (hypoxic exposure period) and then air for 30 min (recovery period). Read More

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http://dx.doi.org/10.1016/j.autneu.2018.03.002DOI Listing
July 2018
5 Reads

Overview of Trigeminal Autonomic Cephalalgias: Nosologic Evolution, Diagnosis, and Management.

Ann Indian Acad Neurol 2018 Apr;21(Suppl 1):S39-S44

Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, United Kingdom.

The term trigeminal autonomic cephalalgias (TACs) encompasses four primary headache disorders - cluster headache, paroxysmal hemicrania (PH), hemicrania continua (HC), short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT)/short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms (SUNA). All of these except HC are characterized by short-lasting headaches. HC is characterized by a continuous unilateral headache that waxes and wanes in its intensity without complete resolution. Read More

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http://dx.doi.org/10.4103/aian.AIAN_348_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909133PMC
April 2018
19 Reads

Cluster Headache: Epidemiology, Pathophysiology, Clinical Features, and Diagnosis.

Ann Indian Acad Neurol 2018 Apr;21(Suppl 1):S3-S8

Department of Basic and Clinical Neuroscience, Headache Group, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Cluster headache is a primary headache disorder affecting up to 0.1% of the population. Patients suffer from cluster headache attacks lasting from 15 to 180 min up to 8 times a day. Read More

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http://dx.doi.org/10.4103/aian.AIAN_349_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909131PMC
April 2018
11 Reads

Involvement of Neuroinflammation in the Pathogenesis of Monocrotaline-Induced Pulmonary Hypertension.

Hypertension 2018 06 30;71(6):1156-1163. Epub 2018 Apr 30.

From the Department of Physiology and Functional Genomics (R.K.S., A.C.O., S.K., G.L., V.A., E.M.R., M.K.R.)

Pulmonary hypertension (PH) is a devastating disease and its successful treatment remains to be accomplished despite recent advances in pharmacotherapy. It has been proposed that PH be considered as a systemic disease, rather than primarily a disease of the pulmonary vasculature. Consequently, an investigation of the intricate interplay between multiple organs such as brain, vasculature, and lung in PH could lead to the identification of new targets for its therapy. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.10934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945302PMC
June 2018
30 Reads
1 Citation
6.480 Impact Factor

Therapeutic Approaches for the Management of Trigeminal Autonomic Cephalalgias.

Neurotherapeutics 2018 04;15(2):346-360

Danish Headache Centre, Department of Neurology, Rigshospitalet-Glostrup, University of Copenhagen, Copenhagen, Denmark.

Trigeminal autonomic cephalalgia (TAC) encompasses 4 unique primary headache types: cluster headache, paroxysmal hemicrania, hemicrania continua, and short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing and short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms. They are grouped on the basis of their shared clinical features of unilateral headache of varying durations and ipsilateral cranial autonomic symptoms. The shared clinical features reflect the underlying activation of the trigeminal-autonomic reflex. Read More

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http://dx.doi.org/10.1007/s13311-018-0618-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935647PMC
April 2018
13 Reads

Investigating Misophonia: A Review of the Empirical Literature, Clinical Implications, and a Research Agenda.

Front Neurosci 2018 7;12:36. Epub 2018 Feb 7.

International Misophonia Research Network, New York, NY, United States.

Misophonia is a neurobehavioral syndrome phenotypically characterized by heightened autonomic nervous system arousal and negative emotional reactivity (e. g., irritation, anger, anxiety) in response to a decreased tolerance for specific sounds. Read More

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http://dx.doi.org/10.3389/fnins.2018.00036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808324PMC
February 2018
15 Reads

Long Non-coding RNA BC168687 is Involved in TRPV1-mediated Diabetic Neuropathic Pain in Rats.

Neuroscience 2018 03 5;374:214-222. Epub 2018 Feb 5.

Department of Physiology, Basic Medical College of Nanchang University, Nanchang 330006, PR China; Jiangxi Provincial Key Laboratory of Autonomic Nervous Function and Disease, Nanchang 330006, PR China. Electronic address:

Long noncoding RNAs (lncRNAs) participate in a diverse range of molecular and biological processes, and dysregulation of lncRNAs has been observed in the pathogenesis of various human diseases. We observed alterations in mechanical withdrawal thresholds (MWT) and thermal withdrawal latencies (TWL) in streptozotocin (STZ)-induced diabetic rats treated with small interfering RNA (siRNA) of lncRNA BC168687. We detected expression of transient receptor potential vanilloid type 1 (TRPV1) in rat dorsal root ganglia (DRG) by a series of molecular experiments. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2018.01.049DOI Listing
March 2018
11 Reads

Treatment of disabling headache with greater occipital nerve injections in a large population of childhood and adolescent patients: a service evaluation.

J Headache Pain 2018 Jan 16;19(1). Epub 2018 Jan 16.

Department of Paediatric Neurology, Great Ormond Hospital for Children NHS Foundation Trust, London, UK.

Background: Pediatric headache disorders can be extremely disabling, with marked reduction in the quality of life of children and their carers. Evidenced-based options for the treatment of primary headache disorders with preventive medication is limited and clinical outcomes are often unsatisfactory. Greater occipital nerve injections represent a rapid and well-tolerated therapeutic option, which is widely used in clinical practice in adults, and has previously shown a good outcome in a pediatric population. Read More

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https://thejournalofheadacheandpain.biomedcentral.com/articl
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http://dx.doi.org/10.1186/s10194-018-0835-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770345PMC
January 2018
22 Reads

Cluster headache and the trigeminal-autonomic reflex: Driving or being driven?

Authors:
Peter J Goadsby

Cephalalgia 2018 07 30;38(8):1415-1417. Epub 2017 Oct 30.

1 Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London.

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http://dx.doi.org/10.1177/0333102417738252DOI Listing
July 2018
10 Reads

International spinal cord injury male sexual function and female sexual and reproductive function basic data sets-version 2.0.

Spinal Cord Ser Cases 2017 10;3:17050. Epub 2017 Aug 10.

Spinal Unit, Centre Calve, Fondation Hopale, Berck-sur-Mer, France.

Study Design: Data set review and modification.

Objective: To describe modifications in the International Spinal Cord Injury (SCI) Male Sexual Function Basic Data Set Version 2.0 and the International SCI Female Sexual and Reproductive Function Basic Data Set Version 2. Read More

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http://dx.doi.org/10.1038/scsandc.2017.50DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550926PMC
August 2017
17 Reads

Anatomical Organization of Urocortin 3-Synthesizing Neurons and Immunoreactive Terminals in the Central Nervous System of Non-Human Primates [ spp.].

Front Neuroanat 2017 24;11:57. Epub 2017 Jul 24.

Department of Anatomy, Institute of Biomedical Sciences, University of São PauloSão Paulo, Brazil.

Urocortin 3 (UCN3) is a neuropeptide member of the corticotropin-releasing factor (CRF) peptide family that acts as a selective endogenous ligand for the CRF, subtype 2 (CRF) receptor. Immunohistochemistry and hybridization data from rodents revealed UCN3-containing neurons in discrete regions of the central nervous system (CNS), such as the medial preoptic nucleus, the rostral perifornical area (PFA), the medial nucleus of the amygdala and the superior paraolivary nucleus. UCN3-immunoreactive (UCN3-ir) terminals are distributed throughout regions that mostly overlap with regions of CRF messenger RNA (mRNA) expression. Read More

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http://dx.doi.org/10.3389/fnana.2017.00057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522884PMC
July 2017
26 Reads

Heart rate variability is enhanced by long-lasting pleasant touch at CT-optimized velocity.

Biol Psychol 2017 09 16;128:71-81. Epub 2017 Jul 16.

Dept. of Psychology, University of Gothenburg, Gothenburg, Sweden; Dept. of Behavioral Sciences in Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.

Introduction: The present study explores whether long-lasting pleasant touch has positive effects on the stress response, reward sensitivity, mood, and interoceptive awareness.

Methods: 40 participants received either 35min of brush stroking targeting C-tactile fibres (CT) or vibration on the forearm, and rated pleasantness and intensity. Prior and after, stress response (cortisol and heart rate variability), reward sensitivity, mood and interoceptive awareness were measured. Read More

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http://dx.doi.org/10.1016/j.biopsycho.2017.07.007DOI Listing
September 2017
6 Reads