184,649 results match your criteria Autonomic Neuroscience: Basic & Clinical [Journal]


Machine learning-based prediction of clinical pain using multimodal neuroimaging and autonomic metrics.

Pain 2018 Oct 17. Epub 2018 Oct 17.

Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States.

Although self-report pain ratings are the gold standard in clinical pain assessment, they are inherently subjective in nature and significantly influenced by multidimensional contextual variables. Although objective biomarkers for pain could substantially aid pain diagnosis and development of novel therapies, reliable markers for clinical pain have been elusive. In this study, individualized physical maneuvers were used to exacerbate clinical pain in patients with chronic low back pain (N = 53), thereby experimentally producing lower and higher pain states. Read More

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October 2018
1 Read

Cardiac Vagus and Exercise.

Physiology (Bethesda) 2019 Jan;34(1):71-80

William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London , London , United Kingdom.

Lower resting heart rate and high autonomic vagal activity are strongly associated with superior exercise capacity, maintenance of which is essential for general well-being and healthy aging. Recent evidence obtained in experimental studies using the latest advances in molecular neuroscience, combined with human exercise physiology, physiological modeling, and genomic data suggest that the strength of cardiac vagal activity causally determines our ability to exercise. Read More

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January 2019

Lower Body Negative Pressure: Physiological Effects, Applications, and Implementation.

Physiol Rev 2019 Jan;99(1):807-851

Physiology Section, Otto Loewi Research Center for Vascular Biology, Immunology and Inflammation, Medical University of Graz , Graz , Austria ; Department of Biomedical Physiology and Kinesiology, Simon Fraser University , Burnaby, British Columbia , Canada ; Battlefield Health & Trauma Center for Human Integrative Physiology, Combat Casualty Care Research Program, US Army Institute of Surgical Research, JBSA Fort Sam Houston, Texas.

This review presents lower body negative pressure (LBNP) as a unique tool to investigate the physiology of integrated systemic compensatory responses to altered hemodynamic patterns during conditions of central hypovolemia in humans. An early review published in Physiological Reviews over 40 yr ago (Wolthuis et al. Physiol Rev 54: 566-595, 1974) focused on the use of LBNP as a tool to study effects of central hypovolemia, while more than a decade ago a review appeared that focused on LBNP as a model of hemorrhagic shock (Cooke et al. Read More

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January 2019
1 Read

Moving from the present to the future of Postural Tachycardia Syndrome - What we need.

Auton Neurosci 2018 Dec 4;215:126-128. Epub 2018 Jul 4.

Autonomic Dysfunction Center, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA.

Our understanding about Postural Tachycardia Syndrome (POTS) has advanced significantly over the last 25 years. Despite the significant advances that have been made in defining the syndrome and finding some treatments for our patients, there is much work to be done to significantly improve our understanding of the disorder and improve therapeutics. In this article, 5 NEEDS are identified that will be required over the next several years if we want future care to move beyond where we are in the present. Read More

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December 2018
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Implications of the Intestinal Microbiota in Diagnosing the Progression of Diabetes and the Presence of Cardiovascular Complications.

J Diabetes Res 2018 12;2018:5205126. Epub 2018 Nov 12.

Department of Internal Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania.

The prevalence of diabetes is steadily rising, and once it occurs, it can cause multiple complications with a negative impact on the whole organism. Complications of diabetes may be macrovascular: such as stroke and ischemic heart disease as well as peripheral vascular and microvascular diseases-retinopathy, nephropathy, and neuropathy. Key factors that cause cardiovascular disease in people with diabetes include hyperglycemia, dyslipidemia, obesity, insulin resistance, inflammation, hypertension, autonomic dysfunction, and decreased vascular response capacity. Read More

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November 2018

A novel adhesive biosensor system for detecting respiration, cardiac, and limb movement signals during sleep: validation with polysomnography.

Nat Sci Sleep 2018 26;10:397-408. Epub 2018 Nov 26.

Neurology Department, Massachusetts General Hospital, Boston, MA 02114, USA.

Background: Although in-lab polysomnography (PSG) remains the gold standard for objective sleep monitoring, the use of at-home sensor systems has gained popularity in recent years. Two categories of monitoring, autonomic and limb movement physiology, are increasingly recognized as critical for sleep disorder phenotyping, yet at-home options remain limited outside of research protocols. The purpose of this study was to validate the BiostampRC sensor system for respiration, electrocardiography (ECG), and leg electromyography (EMG) against gold standard PSG recordings. Read More

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November 2018

Individualized Homeopathic Therapy in a Case of Obesity, Dysfunctional Uterine Bleeding, and Autonomic Dystonia.

Am J Case Rep 2018 Dec 12;19:1474-1479. Epub 2018 Dec 12.

International Academy of Classical Homeopathy, University of the Aegean, Alonissos, Greece.

BACKGROUND Obesity is one of the leading causes of morbidity and mortality globally and challenging to treat because of the multifactorial etiology and presentation. Individualized homeopathy takes into account factors that led to a patient's health condition and hence may have a role in the treatment of obesity and related co-morbidities; co-morbidities that may arising from the same etiology may respond as a whole to homeopathy treatment. CASE REPORT A 39-year-old Russian female who developed multiple problems after severe emotional stress was treated with individualized classical homeopathic therapy. Read More

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December 2018

Radiofrequency catheter ablation of incessant atrial tachycardia in pregnant women with minimal radiation exposure: Lessons from two case studies.

J Cardiol Cases 2014 Jun 28;9(6):213-216. Epub 2014 Feb 28.

Yonsei University Health System, Seoul, Republic of Korea.

During pregnancy, incessant tachyarrhythmias may result in hemodynamic compromise in both the expectant mother and the fetus. The use of antiarrhythmic drugs is typically not safe during pregnancy, and some tachycardias are refractory to pharmacologic treatment due to a significant autonomic imbalance. Catheter ablation is thought to be more effective than medical therapy, but carries the risk of radiation exposure to the fetus. Read More

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Striking improvement in a case of reduced ejection fraction heart failure with baroreflex activation therapy.

J Cardiol Cases 2014 Jul 28;10(1):4-6. Epub 2014 Mar 28.

Cardiovascular Department, IRCCS MultiMedica, Sesto San Giovanni, Milan, Italy.

A patient experiencing chronic New York Heart Association (NYHA) Class III heart failure with reduced left ventricular ejection fraction and signs of right ventricular dysfunction is treated with baroreflex activation therapy (BAT). Despite optimal medical therapy, the patient had repeatedly decompensated and was approaching a refractory terminal stage. BAT chronically reduced muscle sympathetic nerve activity and dramatically improved clinical presentation of the patient to NYHA Class I through 12 months of therapy. Read More

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Elevated resting blood pressure augments autonomic imbalance in posttraumatic stress disorder.

Am J Physiol Regul Integr Comp Physiol 2018 Dec 10;315(6):R1272-R1280. Epub 2018 Oct 10.

Renal Division, Department of Medicine, Emory University School of Medicine , Atlanta, Georgia.

Posttraumatic stress disorder (PTSD) is characterized by increased sympathetic nervous system (SNS) activity, blunted parasympathetic nervous system (PNS) activity, and impaired baroreflex sensitivity (BRS), which contribute to accelerated cardiovascular disease. Patients with PTSD also have chronic stress-related elevations in resting blood pressure (BP), often in the prehypertensive range; yet, it is unclear if elevated resting blood pressure (ERBP) augments these autonomic derangements in PTSD. We hypothesized that compared with normotensive PTSD (N-PTSD), those with ERBP (E-PTSD) have further increased SNS, decreased PNS activity, and impaired BRS at rest and exaggerated SNS reactivity, PNS withdrawal, and pressor responses during stress. Read More

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December 2018
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Brain MRI Lesions are Related to Bowel Incontinence in Multiple Sclerosis.

J Neuroimaging 2018 Dec 11. Epub 2018 Dec 11.

Department of Neurology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

Background And Purpose: Bowel incontinence in multiple sclerosis might be associated with specific lesion sites. This study intended to determine associations between bowel incontinence and cerebral multiple sclerosis lesions using a voxel-wise lesion symptom mapping analysis.

Methods: We conducted a retrospective study of multiple sclerosis patients with self-reported bowel incontinence and matched controls. Read More

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December 2018
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The relationship between aerobic fitness and low-flow-mediated constriction in older adults.

Eur J Appl Physiol 2018 Dec 10. Epub 2018 Dec 10.

Autonomic Cardiovascular Control and Exercise Laboratory, School of Health and Human Performance, Division of Kinesiology, Faculty of Health, Dalhousie University, 6230 South Street, Halifax, NS, B3H 4R2, Canada.

Purpose: Aerobic fitness is directly related to favorable vasodilatory (i.e., flow-mediated dilation; FMD) and vasoconstrictor functions (i. Read More

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December 2018

[Sudden death in epilepsy].

Rev Med Chil 2018 Aug;146(8):902-908

Liga Chilena contra la Epilepsia, Clínica Dávila, Clínica Universidad de los Andes, Santiago, Chile.

The risk of sudden unexpected death in patients with epilepsy (SUDEP), is 20 to 25 times greater than in the general population. This increased risk is seen specially in refractory epilepsy, with an incidence of 9:1,000 patients-years. Risk factors have been established based on retrospective studies, finding that the frequency of seizures, specially generalized tonic clonic seizures, is the most important one. Read More

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August 2018
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Diabetes and Arrhythmias: Pathophysiology, Mechanisms and Therapeutic Outcomes.

Front Physiol 2018 26;9:1669. Epub 2018 Nov 26.

Department of Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, MO, United States.

The prevalence of diabetes is rapidly increasing and closely associated with cardiovascular morbidity and mortality. While the major cardiovascular complication associated with diabetes is coronary artery disease, it is becoming increasingly apparent that diabetes impacts the electrical conduction system in the heart, resulting in atrial fibrillation, and ventricular arrhythmias. The relationship between diabetes and arrhythmias is complex and multifactorial including autonomic dysfunction, atrial and ventricular remodeling and molecular alterations. Read More

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November 2018

Sex Differences in Autonomic Cardiac Control and Oxygen Saturation Response to Short-Term Normobaric Hypoxia and Following Recovery: Effect of Aerobic Fitness.

Front Endocrinol (Lausanne) 2018 23;9:697. Epub 2018 Nov 23.

Discipline of Sport and Exercise Science, School of Rehabilitation and Exercise Sciences, Research Institute for Sport and Exercise Science, University of Canberra, Canberra, ACT, Australia.

The main aims of this study were to investigate autonomic nervous system (ANS) and arterial oxygen saturation (SpO) responses to simulated altitude in males and females, and to determine the association between maximal oxygen uptake (VOmax) and these responses. Heart rate variability (HRV) and SpO were monitored in a resting supine position during Preliminary (6 min normoxia), Hypoxia (10 min, fraction of inspired oxygen (FiO) of 9.6%, simulated altitude ~6,200 m) and Recovery (6 min normoxia) phases in 28 males (age 23. Read More

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November 2018

The genetics of congenital central hypoventilation syndrome: clinical implications.

Appl Clin Genet 2018 15;11:135-144. Epub 2018 Nov 15.

Division of Pediatric Pulmonology and Sleep Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA,

Congenital central hypoventilation syndrome (CCHS) is a rare genetic disorder of the autonomic nervous system (ANS) and respiratory control. This disorder, formerly referred to as Ondine's curse, is due to a mutation in the gene that affects the development of the neural crest cells. CCHS has an autosomal dominant pattern of inheritance. Read More

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November 2018

Renal nerves contribute to hypertension in Schlager BPH/2J mice.

Hypertens Res 2018 Dec 10. Epub 2018 Dec 10.

Neuropharmacology Laboratory, Baker Heart and Diabetes Institute, Melbourne, Australia.

Schlager mice (BPH/2J) are hypertensive due to a greater contribution of the sympathetic nervous system (SNS) and renin-angiotensin system (RAS). The kidneys of BPH/2J are hyper-innervated suggesting renal nerves may contribute to the hypertension. We therefore determined the effect of bilateral renal denervation (RD) on hypertension in BPH/2J. Read More

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December 2018

The Effect of Exercise Training on Autonomic Cardiovascular Regulation: From Cardiac Patients to Athletes.

Curr Sports Med Rep 2018 Dec;17(12):473-479

Italian Federation of Sports Medicine, Rome, ITALY.

Exercise training is increasingly promoted for physical and mental health and represents a major factor in both primary and secondary prevention of cardiovascular (CV) diseases. The beneficial effects of exercise, in part, can be ascribed to adaptations of neural CV regulation through several mechanisms. In this article, we summarize how exercise training affects neural CV regulation and outline the plasticity of neural network in the continuum from cardiac patients to elite athletes. Read More

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December 2018

Translating peripheral bladder afferent mechanosensitivity to neuronal activation within the lumbosacral spinal cord of mice.

Pain 2018 Dec 5. Epub 2018 Dec 5.

Visceral Pain Research Group, Centre for Neuroscience, College of Medicine and Public Health, Flinders University, Bedford Park, South Australia, 5042, AUSTRALIA.

Primary afferent neurons transduce distension of the bladder wall into action potentials that are relayed into the spinal cord and brain, where autonomic reflexes necessary for maintaining continence are coordinated with pathways involved in sensation. However, the relationship between spinal circuits involved with physiological and nociceptive signalling from the bladder have only been partially characterised. We used ex-vivo bladder afferent recordings to characterise mechanosensitive afferent responses to graded distension (0-60mmHg) and retrograde tracing from the bladder wall to identify central axon projections within the dorsal horn of the lumbosacral spinal cord. Read More

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December 2018
2 Reads

Investigating neurogenic bowel in experimental spinal cord injury: where to begin?

Neural Regen Res 2019 Feb;14(2):222-226

Department of Neural & Behavioral Sciences, Penn State University College of Medicine, Hershey, PA, USA.

The devastating losses following traumatic spinal cord injury (SCI) encompass the motor, sensory and autonomic nervous systems. Neurogenic bowel is a slow transit colonic dysfunction marked by constipation, rectal evacuation difficulties, decreased anorectal sensation, fecal incontinence or some combination thereof. Furthermore, neurogenic bowel is one of the most prevalent comorbidities of SCI and is recognized by afflicted individuals and caregivers as a lifelong physical and psychological challenge that profoundly affects quality of life. Read More

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February 2019

Improved decision-making and psychophysiological responses in mesial temporal lobe epilepsy after anterior temporal lobectomy.

Epileptic Disord 2018 Dec 10. Epub 2018 Dec 10.

Istanbul University, Cerrahpaşa Faculty of Medicine, Department of Neurology.

The somatic marker hypothesis is an influential model of human decision-making postulating that somatic feedback to the brain enhances decision-making in ambiguous circumstances, i.e. when the probabilities of various outcomes are unknown. Read More

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December 2018

Lack of improvement in autonomic cardiac tone after sacubitril/valsartan at lower than target doses.

J Electrocardiol 2018 Nov 28;52:99-100. Epub 2018 Nov 28.

Department of Cardiology, Virgen de la Arrixaca University Hospital, Murcia, Spain.

Autonomic regulation plays a role in the progression of heart failure with reduced ejection fraction (HrEF).Twenty-one HFrEF patients, 60.8 ± 13. Read More

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November 2018

Heart rate variability in alcohol use: A review.

Pharmacol Biochem Behav 2018 Dec 6. Epub 2018 Dec 6.

Yale University School of Medicine, United States of America.

Background: Prior studies have shown that resting heart rate variability (HRV) is reduced in those with alcohol use disorders (AUD). However, HRV following an acute stressful stimulus (reactive HRV), and the relationship between resting or reactive HRV and drinking, craving and relapse in AUD have received less attention.

Methods: Studies using HRV in relationship to acute or chronic alcohol consumption were included in this review. Read More

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December 2018
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Utility of Diagnostic Studies for Upper Gastrointestinal Symptoms in Children with Orthostatic Intolerance.

J Pediatr 2018 Oct 18. Epub 2018 Oct 18.

Division of Gastroenterology, Children's National Health System, Washington, DC. Electronic address:

Objective: To assess the utility of gastrointestinal (GI) diagnostic studies in the evaluation of patients with orthostatic intolerance.

Study Design: Medical records of 103 consecutive children/young adults with orthostatic intolerance and gastrointestinal symptoms were reviewed. All patients had undergone antroduodenal manometry in conjunction with the tilt table test, autonomic testing, and upper gastrointestinal endoscopy (EGD). Read More

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October 2018

Influence of chewing on expression level of human beta-defensin 2 and secretory immunoglobulin A in the epithelium.

J Prosthodont Res 2018 Dec 7. Epub 2018 Dec 7.

Department of Removable Prosthodontics & Gerodontology, Tokyo Dental College, Tokyo, Japan.

Purpose: This study aimed to clarify the influence of chewing on human β-defensin 2 (hBD-2) and secretory immunoglobulin A (SIgA) expression levels.

Methods: We included 15 healthy males with no missing teeth (mean age, 25.5±2. Read More

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December 2018

AAPT Diagnostic Criteria for Peripheral Neuropathic Pain: Focal and Segmental Disorders.

J Pain 2018 Dec 4. Epub 2018 Dec 4.

Department of Anesthesiology and Washington University Pain Center, Washington University School of Medicine, St Louis, MO.

Peripheral neuropathic pain is among the most prevalent types of neuropathic pain. No comprehensive peripheral neuropathic pain classification system that incorporates contemporary clinical, diagnostic, biological, and psychological information exists. To address this need, this article covers the taxonomy for 4 focal or segmental peripheral neuropathic pain disorders, as part of the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) public-private partnership and the American Pain Society (APS) collaborative to develop a standardized, evidence-based taxonomy initiative: the ACTTION-APS Pain Taxonomy (AAPT). Read More

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December 2018
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Relation of Exercise Heart Rate Recovery to Predict Cardiometabolic Syndrome in Men.

Am J Cardiol 2018 Nov 24. Epub 2018 Nov 24.

Preventive Cardiology and Cardiac Rehabilitation, Beaumont Health, Royal Oak, Michigan.

We examined the hypothesis that delayed heart rate recovery (HRR) after exercise testing, an estimate of decreased autonomic function, predicts the risk of cardiometabolic syndrome (MetS) and is associated with continuous MetS risk scores in healthy men. Participants were 2,740 men who underwent general health examinations and had no evidence of MetS, cardiovascular diseases, diabetes, and hypertension at baseline. Baseline HRR was calculated as the difference between peak heart rate attained during exercise testing and the heart rate at 1 (HRR 1) and 2 minutes (HRR 2) after test termination. Read More

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November 2018

Effects of consecutive domestic and international tournaments on heart rate variability in an elite rugby sevens team.

J Sci Med Sport 2018 Nov 28. Epub 2018 Nov 28.

Department for Health, University of Bath, United Kingdom.

Objectives: The purpose of this study was to evaluate heart rate variability and athlete self-report measures of recovery status (ASRM) in response to consecutive domestic and international tournaments among an elite rugby sevens team.

Design: Retrospective.

Methods: Olympic-level rugby sevens players (n=10) recorded post-waking natural logarithm of the root mean square of successive differences (LnRMSSD) and ASRM (sleep quality, energy, soreness, recovery and mood) throughout a 1-week baseline period and daily thereafter throughout a domestic and subsequent international tournament, separated by five days. Read More

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November 2018

Cerebellar impairment during an orthostatic challenge in patients with neurogenic orthostatic hypotension.

Clin Neurophysiol 2018 Sep 6. Epub 2018 Sep 6.

School of Kinesiology, Western University, London, Ontario, Canada; Department of Clinical Neurological Sciences, University Hospital, London Health Sciences Centre, London, Ontario, Canada; Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada. Electronic address:

Objective: Compare activation patterns within the cortical autonomic network in patients with neurogenic orthostatic hypotension (NOH) versus healthy age-matched controls during an orthostatic challenge.

Methods: Fifteen health controls and 15 NOH patients performed 3 Valsalva maneuvers, and 5-min of lower-body negative pressure (LBNP) during a functional brain MRI.

Results: Compared to controls, NOH patients had significantly less activation within the cerebellum during both LBNP and VM. Read More

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September 2018

Pupillary hippus as clinical manifestation of refractory autonomic nonconvulsive status epilepticus: Pathophysiological implications.

Seizure 2018 Dec 15;63:102-104. Epub 2018 Nov 15.

Department of Intensive Medicine, Marqués de Valdecilla University Hospital, Santander, Cantabria, Spain; Department of Biomedical Research Institute (IDIVAL), Santander, Spain.

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December 2018

Ocular Accommodative Response is Modulated as a Function of Physical Exercise Intensity.

Curr Eye Res 2018 Dec 7. Epub 2018 Dec 7.

a Department of Optics, Faculty of Sciences , University of Granada , Granada , Spain.

Purpose: The present study aimed (1) to examine the impact of two high-intensity interval training (HIIT) protocols differing in exercise intensity (low-intensity and high-intensity) on the dynamic accommodative response (AR), and (2) to elucidate whether the ocular accommodation changes are associated with the function of the autonomic nervous system during stimulus processing, as measured by the heart rate variability (HRV).

Methods: Twenty physically active university students (9 women; age = 23.9 ± 3. Read More

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December 2018

Sympathetic Responses Induced by Radiofrequency Catheter Ablation of Atrial Fibrillation.

Am J Physiol Heart Circ Physiol 2018 Dec 7. Epub 2018 Dec 7.

Penn State College of Medicine, Penn State Heart and Vascular Institute, United States.

Radiofrequency catheter ablation (RFCA) is a frequently performed procedure in patients with atrial fibrillation. Prior studies have shown that the RFCA may directly stimulate vagal afferents during the procedure, while the vagal tone assessed by heart rate variability (HRV) is lowered weeks post the RFCA procedure. The effects of RFCA performed in the left atrium on sympathetic nerve activity has not been assessed. Read More

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December 2018

Posttraumatic Headache.

Authors:
Brigid Dwyer

Semin Neurol 2018 Dec 6;38(6):619-626. Epub 2018 Dec 6.

Department of Neurology, Boston University School of Medicine, Boston, Massachusetts.

Posttraumatic headaches are among the most challenging complaints after mild traumatic brain injury (mTBI). They are a debilitating problem experienced by patients after TBI of all severities. Up to 90% of mild TBI patients experience headache, particularly if female and with a premorbid history of primary headache. Read More

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December 2018
3 Reads

Cluster Headache and Other Trigeminal Autonomic Cephalalgias.

Authors:
Brian E McGeeney

Semin Neurol 2018 Dec 6;38(6):603-607. Epub 2018 Dec 6.

Department of Neurology, Boston University School of Medicine, Boston, Massachusetts.

The trigeminal autonomic cephalalgias are a group of distinct primary headache disorders that share common characteristics of strict unilateral headache often accompanied by unilateral cranial autonomic features. Cluster headache is the most well-known example, but other than neurologists, practitioners often have limited familiarity with these disorders and treatment options. Delays in diagnosis are typical and treatment options remain suboptimal, associated with limited scientific research into these brain disorders. Read More

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December 2018
6 Reads

Heart Rate Variability Predicts Older Adults' Avoidance of Negativity.

J Gerontol B Psychol Sci Soc Sci 2018 Dec 6. Epub 2018 Dec 6.

Department of Psychology, University of Warwick, Coventry, UK.

Objectives: The ability to produce situation-appropriate cognitive and emotional responses is dependent on autonomic nervous system (ANS) functionality. Heart rate variability (HRV) is an index of ANS functionality, and resting HRV levels have been associated with cognitive control and inhibitory capacity in young adults, particularly when faced with emotional information. As older adults' greater preference for positive and avoidance of negative stimuli (positivity effect) is thought to be dependent on cognitive control, we hypothesized that HRV could predict positivity-effect magnitude in older adults. Read More

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December 2018
2 Reads

Cardiac parasympathetic activity and ventricular diastolic interactions in individuals with spinal cord injury.

Spinal Cord 2018 Dec 5. Epub 2018 Dec 5.

Department of Kinesiology, Brock University, 1812 Sir Isaac Brock Way, St. Catharines, L2S 3A1, ON, Canada.

Study Design: Cohort cross-sectional study.

Objective: To investigate the relationship between cardiac vagal activity and left ventricular filling at rest and during vagal stimulation, via the cold face test (CFT), in individuals with spinal cord injury (SCI).

Setting: University-based laboratory at Brock University, St. Read More

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December 2018
1 Read

Autonomic dysfunction in programmed hypertension.

J Hum Hypertens 2018 Dec 5. Epub 2018 Dec 5.

School of Medical Sciences & Bosch Institute, The University of Sydney, Sydney, Australia.

Hypertension is an important modifiable risk factor for cardiovascular diseases. Its high prevalence, combined with the significant morbidity and mortality associated with secondary complications, make it a major public health concern. Despite decades of research, over 95% of all cases of hypertension remain of unknown etiology, necessitating that treatments target the established symptoms and not the cause. Read More

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December 2018
2 Reads

Recognition, Assessment, and Pharmacotherapeutic Treatment of Alcohol Withdrawal Syndrome in the Intensive Care Unit.

Crit Care Nurs Q 2019 Jan/Mar;42(1):12-29

Department of Pharmacy Services, UC Health-University of Cincinnati Medical Center, Ohio (Drs Foertsch, Winter, Droege, and Ernst); University of Cincinnati James L. Winkle College of Pharmacy, Ohio (Drs Foertsch, Winter, Rhoades, Martin, Droege, and Ernst); Department of Pharmacy Services, The Christ Hospital Health Network, Cincinnati, Ohio (Dr Rhoades); and Department of Pharmacy Services, St Elizabeth Healthcare, Edgewood, Kentucky (Dr Martin).

Alcohol withdrawal syndrome (AWS) is a complex neurologic disorder that develops after an acute reduction in or cessation of chronic alcohol consumption that alters neurotransmitter conduction. The incidence of AWS in the intensive care unit varies, but has been associated with poor outcomes. This is primarily driven by downregulation of gamma-aminobutyric acid (GABA) leading to autonomic excitability and psychomotor agitation. Read More

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December 2018
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Unconstrained Estimation of HRV Indices after Removing Respiratory Influences from Heart Rate.

IEEE J Biomed Health Inform 2018 Dec 3. Epub 2018 Dec 3.

Objective: This paper proposes an approach to better estimate the sympathovagal balance (SB) and the respiratory sinus arrhythmia (RSA) after separating respiratory influences from the heart rate (HR).

Methods: The separation is performed using orthogonal subspace projections and the approach is first tested using simulated HR and respiratory signals with different spectral properties. Then, RSA and SB are estimated during autonomic blockade and stress using the proposed approach and the classical heart rate variability (HRV) analysis. Read More

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December 2018
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Loss of m A on FAM134B promotes adipogenesis in porcine adipocytes through m A-YTHDF2-dependent way.

IUBMB Life 2018 Dec 2. Epub 2018 Dec 2.

College of Animal Sciences, Key Laboratory of Animal Nutrition & Feed Sciences, Ministry of Agriculture, Zhejiang Provincial Laboratory of Feed and Animal Nutrition, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.

N -methyladenosine (m A) mRNA modification plays an important role in adipogenesis, but its role on single gene remains unexplored. Family with Sequence Similarity 134, Member B (FAM134B) is a cis-Golgi transmembrane protein that known to be necessary for the long-term survival of nociceptive and autonomic ganglion neurons. Recent work has shown that FAM134B plays a pivotal role in lipid homeostasis and was identified as its significant m A level difference between Chinese local Jinhua pigs and Landrace through RNA-sequence. Read More

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December 2018

Regulation of Sensory Nerve Conduction Velocity (SCV) of Human Bodies Responding to Annual Temperature Variations in Natural Environments.

Indoor Air 2018 Nov 30. Epub 2018 Nov 30.

Joint International Research Laboratory of Green Buildings and Built Environments (Ministry of Education), Chongqing University, Chongqing, 400045, China.

The extensive research interests in environmental temperature can be linked to human productivity/performance as well as comfort and health; while the mechanisms of physiological indices responding to temperature variations remain incompletely understood. This study adopted a physiological sensory nerve conduction velocity (SCV) as a temperature-sensitive biomarker to explore the thermoregulatory mechanisms of human responding to annual temperatures. The measurements of subjects' SCV (over 600 samples) were conducted in a naturally ventilated environment over all four seasons. Read More

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November 2018
1 Read
4.202 Impact Factor

Skin nerve α-synuclein deposits in Parkinson's disease and other synucleinopathies: a review.

Authors:
Donadio Vincenzo

Clin Auton Res 2018 Nov 30. Epub 2018 Nov 30.

IRCCS Istituto Delle Scienze Neurologiche di Bologna (Italy), UOC Clinica Neurologica, Via Altura 3, 40139, Bologna, Italy.

Purpose: The in vivo diagnosis of synucleinopathies is an important research aim since clinical diagnostic criteria show low accuracy. The skin innervation, especially the autonomic subdivision, is a useful region to search for abnormal α-syn aggregates in synucleinopathies since the peripheral sympathetic nerves can be the earliest-affected neural region and autonomic symptoms may precede the classical symptoms of these disorders.

Methods: The major advantages of skin biopsy as an in vivo diagnostic tool for synucleinopathies are that it is an inexpensive and easy-to-perform technique requiring only limited facilities, and that it is repeatable in long-term studies as it causes only minor discomfort to the patient. Read More

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November 2018
1 Read

Glial Activation and Expression of the Serotonin Transporter in Chronic Fatigue Syndrome.

Front Psychiatry 2018 16;9:589. Epub 2018 Nov 16.

Department of Neuroinflammation and Brain Fatigue Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Fatigue is commonly reported in a variety of illnesses and has major impact on quality of life. Chronic fatigue syndrome (CFS) is a debilitating syndrome of unknown etiology. The clinical symptoms include problems in neuroendocrine, autonomic, and immune systems. Read More

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November 2018

[Obstructive sleep apnea-hypopnea and stroke].

Medicina (B Aires) 2018 ;78(6):427-435

Departamento de Medicina, Universitat Autónoma de Barcelona, Barcelona, España.

Stroke, one of the main causes of disability and death worldwide, is frequently associated to the obstructive sleep apnea-hypopnea syndrome. This sleep disorder has been demonstrated to be an independent risk factor for stroke, and therefore its investigation and treatment has been recommended for patients with stroke. Mechanisms relating these two clinical disorders include: oxidative stress, cerebral blood flow alterations, autonomic dysfunction, and hypercoagulability, as well as patent foramen ovale, blood pressure, and heart rhythm disorders. Read More

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January 2018
1 Read

Reduced professional efficacy is associated with a blunted salivary alpha-amylase awakening response.

Physiol Behav 2018 Nov 29;199:292-299. Epub 2018 Nov 29.

School of Psychology and Public Health, La Trobe University, Bundoora, VIC 3086, Australia. Electronic address:

The job demands-resources model (JD-R) has shown an ability to predict worker engagement and exhaustion, yet to our knowledge, research has not been conducted that assesses the JD-R model with physiological indicators of chronic stress and burnout. Using the JD-R model, we assessed if occupational stress and burnout were related to dysregulated cortisol and salivary alpha-amylase awakening responses (sAA-AR). Professional apprentice jockeys comprising of males (n = 14) and females (n = 18) provided morning saliva samples and completed self-report measures relating to job demands and resources, burnout, and perceived mental and physical health. Read More

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November 2018
1 Read

Exploring the pre-morbid contexts in which central sensitisation developed in individuals with non-specific chronic low back pain. A qualitative study.

Braz J Phys Ther 2018 Nov 8. Epub 2018 Nov 8.

Faculty of Health, Psychology and Social Care, Manchester Metropolitan University, Manchester, Birley Campus, Manchester, United Kingdom.

Background: Central sensitisation pain is a predominant mechanism in a proportion of individuals with non-specific chronic low back pain and is associated with poor outcomes. It is proposed that the pre-morbid experiences and contexts may be related to the development of central sensitisation.

Objectives: The objective of this study was to explore the pre-morbid experiences and personal characteristics of participants with central sensitisation pain from a non-specific chronic low back pain population. Read More

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November 2018
1 Read

Recursive model identification for the analysis of the autonomic response to exercise testing in Brugada syndrome.

Artif Intell Med 2018 Nov 28. Epub 2018 Nov 28.

Univ Rennes, CHU Rennes, Inserm, LTSI UMR 1099, F-35000 Rennes, France.

This paper proposes the integration and analysis of a closed-loop model of the baroreflex and cardiovascular systems, focused on a time-varying estimation of the autonomic modulation of heart rate in Brugada syndrome (BS), during exercise and subsequent recovery. Patient-specific models of 44 BS patients at different levels of risk (symptomatic and asymptomatic) were identified through a recursive evolutionary algorithm. After parameter identification, a close match between experimental and simulated signals (mean error = 0. Read More

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November 2018
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Relation of Hepatic Fibrosis in Nonalcoholic Fatty Liver Disease to Left Ventricular Diastolic Function and Exercise Tolerance.

Am J Cardiol 2018 Nov 6. Epub 2018 Nov 6.

Division of Gastroenterology - Hepatology Division, Virginia Commonwealth University, Richmond, Virginia.

The purpose of this study was to determine the relation between liver histology, exercise tolerance, and diastolic function in patients with nonalcoholic fatty liver disease (NAFLD). Myocardial remodeling and diastolic dysfunction have been associated with NAFLD. However, its physiological impact and relationship to the histological severity of NAFLD is not known. Read More

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November 2018
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Is metabolic syndrome related to exercise cardiac autonomic modulation in obese adults?

Auton Neurosci 2018 Nov 14. Epub 2018 Nov 14.

Department of Physical Education, Center of Health Sciences, State University of Maringa, Maringa, Brazil.

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November 2018