8,008 results match your criteria Autonomic Neuropathy

Spinal muscular atrophy with respiratory distress type 1 (SMARD1): a rare cause of hypotonia, diaphragmatic weakness, and respiratory failure in infants.

Turk J Pediatr 2022 ;64(2):364-374

Department of Pediatric Neurology, University of Health Sciences, Dr. Behçet Uz Children's Education and Research Hospital, İzmir.

Background: Spinal muscular atrophy with respiratory distress type 1 (SMARD1) is a very rare autosomal recessive disorder caused by mutations in the immunoglobulin μ-binding protein-2 (IGHMBP2) gene on chromosome 11q13.2-q13.4. Read More

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Neuropathic symptoms with SARS-CoV-2 vaccination.

medRxiv 2022 May 17. Epub 2022 May 17.

Background And Objectives: Various peripheral neuropathies, particularly those with sensory and autonomic dysfunction may occur during or shortly after acute COVID-19 illnesses. These appear most likely to reflect immune dysregulation. If similar manifestations can occur with the vaccination remains unknown. Read More

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Diabetes-Related Microvascular Complications - A Practical Approach.

Prim Care 2022 Jun 22;49(2):239-254. Epub 2022 Apr 22.

Department of Internal Medicine, East Carolina University, 521 Moye Boulevard, 2nd Floor, Greenville, NC 27834, USA.

Diabetes-related microvascular complications include diabetic neuropathy (eg, diabetic symmetric polyneuropathy (DSPN), cardiac autonomic neuropathy, gastroparesis, enteropathy, erectile dysfunction, female sexual dysfunction, and hypoglycemia unawareness), diabetic kidney disease (DKD), and diabetes-related eye disease (eg, diabetic retinopathy (DR) and cataract). Both diabetes duration and degree of glycemic control strongly correlate with the development of microvascular complications. The development of diabetes-related microvascular complications interferes with the patient's quality of life and poses higher health system costs. Read More

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Neurotrophic keratitis in hereditary sensory autonomic neuropathy.

Natl Med J India 2022 Sep-Oct;34(5):316

Dr Rajendra Prasad Centre for Ophthalmic Sciences All India Institute of Medical Sciences, New Delhi, India.

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[Small Fiber Neuropathy with Inadequate Response to Medical Therapy: Diagnosis and Treatment of Small Fiber Neuropathy].

Chieko Suzuki

Brain Nerve 2022 May;74(5):614-620

Department of Neurology, Hirosaki University Graduate School of Medicine and School of Medicine.

Small-fiber neuropathies are a heterogeneous group of disorders affecting thinly myelinated Aδ and unmyelinated C fibers. Patients generally present with neuropathic pain, while dysesthesia, allodynia, pain, burning sensations, and cold sensations are frequently present in a length-dependent pattern. Additional autonomic features of the gastrointestinal, urinary, or cardiovascular systems are frequently observed. Read More

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Efficacy of Wen-Luo-Tong on Peripheral Neuropathy Induced by Chemotherapy or Target Therapy: A Randomized, Double-Blinded, Placebo-Controlled Trial.

Chin J Integr Med 2022 May 18. Epub 2022 May 18.

Integrative Oncology Department of Chinese Medicine and Western Medicine, China-Japan Friendship Hospital, Beijing, 100029, China.

Objective: To evaluate the efficacy of Wen-Luo-Tong Granules (WLT) local administration in the treatment of patients with peripheral neuropathy (PN) induced by chemotherapy or target therapy.

Methods: This study is a randomized, double-blinded, and placebo-controlled trial. Seventy-eight patients with PN induced by chemotherapy or target therapy were enrolled from China-Japan Friendship Hospital between July 2019 and January 2020. Read More

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Risk factors for lower bone mineral density in older adults with type 1 diabetes: a cross-sectional study.

Lancet Diabetes Endocrinol 2022 May 13. Epub 2022 May 13.

Case Western Reserve University/Rainbow Babies and Children's Hospital, Cleveland, OH, USA.

Background: Type 1 diabetes is associated with lower bone mineral density (BMD) and increased fracture risk, but little is known regarding the effects of diabetes-related factors on BMD. We assessed whether these factors are associated with lower hip BMD among older adults with type 1 diabetes.

Methods: This cross-sectional study was embedded in a long-term observational study, the Epidemiology of Diabetes Interventions and Complications study (EDIC), a cohort of participants with type 1 diabetes, who were originally enrolled in the Diabetes Control and Complications Trial (DCCT), and were followed-up for more than 30 years at 27 sites in the USA and Canada. Read More

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Neuromodulation for trigeminal neuralgia.

J Korean Neurosurg Soc 2022 May 16. Epub 2022 May 16.

Incheon St. Mary's Hospital, The Catholic University of Korea, Incheon, Korea.

Clinical studies on neuromodulation intervention for trigeminal neuralgia have not yet shown promising results. This might be due to the fact that the pathophysiology of chronic trigeminal neuropathy is not yet fully understood. Chronic trigeminal neuropathy includes trigeminal autonomic neuropathy, painful trigeminal neuropathy, and persistent idiopathic facial pain. Read More

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Intravenouse immunoglobuline in dysautonomia.

Clin Immunol 2022 May 12:109039. Epub 2022 May 12.

Federal State Budget Educational Institution of Higher Education "St. Petersburg State University", University Emb., 7-9, Saint-Petersburg 199034, Russia; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Zabludowicz Center for Autoimmune Diseases, Chaim Sheba Medical Center, 52621 Tel Ha Shomer, Israel; Ariel University, Ariel, Israel.

Nowadays intravenous immunoglobulin (IVIg) treatment is considered to play a promising role in the autoimmune disease therapy. Despite its significant beneficial effects, the precise mechanism of action needs further studies, as well as recommended dosage in the treatment of autoimmune dysautonomia. In some diseases, like Guillain-Barre syndrome (GBS) and chronic inflammatory demyelinating neuropathy (CIDP), IVIg has a strong evidence that allows to recommend and prescribe the medication, while in other diseases only single case studies are available that requires further research. Read More

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Relationship Between Esophageal Motility Disorders and Autonomic Nervous System in Diabetic Patients: Pilot North African Study.

Am J Mens Health 2022 May-Jun;16(3):15579883221098588

Laboratory of Physiology, Faculty of Medicine of Sousse, University of Sousse, Sousse, Tunisia.

Little attention has been given to esophageal disorders in diabetes mellitus. Pathophysiology of esophageal motility disorders (EMD) in patients with diabetes mellitus is multifactorial. The aims of the present study were: (a) to evaluate the prevalence of EMD in patients with Type 2 diabetes mellitus and (b) to determine the relationship between EMD and autonomic neuropathy as assessed by heart rate variability (HRV). Read More

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QTc interval prolongation due to spinal anesthesia in patients with and without diabetes: an observational study.

BMC Anesthesiol 2022 May 13;22(1):143. Epub 2022 May 13.

Department of Anesthesiology and Pain Medicine, Inha University College of Medicine, Incheon, Korea.

Background: Spinal anesthesia and autonomic neuropathy (caused by diabetes) prolong the QTc interval. Changes in the duration of the QTc interval following subarachnoid blockade in patients with diabetes have not been evaluated. We hypothesized that after subarachnoid blockade, QTc interval prolongation would be greater in patients with diabetes than in those without. Read More

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Interpreting resting heart rate variability in complex populations: the role of autonomic reflexes and comorbidities.

Clin Auton Res 2022 May 14. Epub 2022 May 14.

Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Purpose: Resting heart rate variability (HRV) is an important biomarker linking mental health to cardiovascular outcomes. However, resting HRV is also impaired in autonomic neuropathy, a common and underdiagnosed complication of common medical conditions which is detected by testing autonomic reflexes. We sought to describe the relationship between autonomic reflex abnormalities and resting HRV, taking into consideration medical comorbidities and demographic variables. Read More

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Role of skin punch biopsy in diagnosis of small fiber neuropathy-A review for the neuropathologist.

Indian J Pathol Microbiol 2022 May;65(Supplement):S329-S336

Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

Over the last three decades, skin punch biopsy has become the gold standard for diagnosis of small fiber neuropathies, including autonomic neuropathies commonly seen in diabetics, patients with HIV, and children with hereditary sensory autonomic neuropathies and toxin-induced neuropathy. Clinical, biochemical, electrophysiological tests are inconclusive, making it difficult to diagnose and initiate treatment. A skin punch biopsy is easy to perform in the outpatient clinic, is highly sensitive, and provides an objective diagnosis. Read More

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Sonographic Evaluation of the Gallbladder in Adult Patients With Type 2 Diabetes Mellitus.

Cureus 2022 Apr 7;14(4):e23920. Epub 2022 Apr 7.

Department of Radiology, University College Hospital, Ibadan, NGA.

Introduction And Aim: Diabetes mellitus (DM) is one of the most common non-communicable diseases worldwide. Diabetics with autonomic neuropathy tend to have larger gallbladder (GB) with poor contraction after fatty meals predisposing them to gallstones and cholecystitis. This may be prevented and treated if detected early using ultrasound. Read More

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Naringin Relieves Diabetic Cardiac Autonomic Neuropathy Mediated by P2Y Receptor in Superior Cervical Ganglion.

Front Pharmacol 2022 21;13:873090. Epub 2022 Apr 21.

Department of Physiology, Medical School of Nanchang University, Nanchang, China.

Diabetes mellitus (DM), an emerging chronic epidemic, contributes to mortality and morbidity around the world. Diabetic cardiac autonomic neuropathy (DCAN) is one of the most common complications associated with DM. Previous studies have shown that satellite glial cells (SGCs) in the superior cervical ganglia (SCG) play an indispensable role in DCAN progression. Read More

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Pharmacotherapy of Painful Diabetic Neuropathy: A Clinical Update.

Sisli Etfal Hastan Tip Bul 2022 28;56(1):1-20. Epub 2022 Mar 28.

Department of Endocrinology & Metabolism, Lancashire Teaching Hospitals NHS Trust, United Kingdom; The University of Manchester, Manchester, UK; Manchester Metropolitan University, Manchester, UK.

The rising prevalence of diabetes mellitus (DM) leads on to an increase in chronic diabetic complications. Diabetic peripheral neuropathies (DPNs) are common chronic complications of diabetes. Distal symmetric polyneuropathy is the most prevalent form. Read More

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The Predictive Value of Serum Calcium on Heart Rate Variability and Cardiac Function in Type 2 Diabetes Patients.

Front Endocrinol (Lausanne) 2022 14;13:864008. Epub 2022 Apr 14.

Department of Endocrinology & Metabolism, Renmin Hospital of Wuhan University, Wuhan, China.

Background: Cardiovascular autonomic neuropathy (CAN) is common in patients with type 2 diabetes mellitus (T2DM), mainly presented as decreased heart rate variability (HRV) which often leads to cardiac death. However, HRV measurement is not convenient in most clinics. Therefore, identifying high-risk patients for CAN in diabetes with easier measurements is crucial for the early intervention and prevention of catastrophic consequences. Read More

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Cardiovascular Autonomic Neuropathy in Type 1 Diabetes Is Associated With Disturbances in TCA, Lipid, and Glucose Metabolism.

Front Endocrinol (Lausanne) 2022 14;13:831793. Epub 2022 Apr 14.

Complications Research, Steno Diabetes Center Copenhagen, Herlev, Denmark.

Introduction: Diabetic cardiovascular autonomic neuropathy (CAN) is associated with increased mortality and morbidity. To explore metabolic mechanisms associated with CAN we investigated associations between serum metabolites and CAN in persons with type 1 diabetes (T1D).

Materials And Methods: Cardiovascular reflex tests (CARTs) (heart rate response to: deep breathing; lying-to-standing test; and the Valsalva maneuver) were used to diagnose CAN in 302 persons with T1D. Read More

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A study of electrocardiographic and 2D echocardiographic changes in type 2 diabetes mellitus patients without cardiovascular symptoms.

J Family Med Prim Care 2022 Mar 10;11(3):1036-1039. Epub 2022 Mar 10.

Department of Medicine, B. J. Government Medical College and Sassoon General Hospital, Pune, Maharashtra, India.

Context: Cardiovascular diseases in diabetic patients are mostly asymptomatic due to autonomic neuropathy. Many patients with left ventricular dysfunction remain undiagnosed and untreated until advance disease causes disability. This delay could be avoided if screening techniques are used to identify left ventricular dysfunction in its preclinical phase. Read More

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Possible complex regional pain syndrome following SARS-CoV-2 infection: Case report.

SAGE Open Med Case Rep 2022 21;10:2050313X221093111. Epub 2022 Apr 21.

Department of Medicine, University of Sri Jayewardenepura, Nugegoda, Sri Lanka.

SARS-CoV-2 infection has various manifestations including neurological and musculoskeletal system involvement. COVID-19 infection causes peripheral nerve lesions including small fibre neuropathy. Complex regional pain syndrome is a debilitating neurological condition manifested by predominantly pain associated with other sensory, motor, autonomic and tropic involvement. Read More

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Metformin-induced vitamin B12 deficiency can cause or worsen distal symmetrical, autonomic and cardiac neuropathy in the patient with diabetes.

David S H Bell

Diabetes Obes Metab 2022 May 2. Epub 2022 May 2.

Southside Endocrinology, Birmingham, Alabama, USA.

Metformin blocks the absorption of vitamin B12 through a mechanism that has not been established but could be because of interference with the calcium-dependent binding of the intrinsic factor vitamin B12 complex to the cubam receptor in the terminal ileum. The subsequent deficiency of vitamin B12 may cause or accelerate distal symmetrical and autonomic neuropathy in the patient with diabetes. Several observational studies and meta-analyses have reported a significant association between metformin utilization and vitamin B12 deficiency. Read More

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Dental pulp stem cells as a therapy for congenital entero-neuropathy.

Sci Rep 2022 Apr 28;12(1):6990. Epub 2022 Apr 28.

Department of Pediatric Surgery, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.

Hirschsprung's disease is a congenital entero-neuropathy that causes chronic constipation and intestinal obstruction. New treatments for entero-neuropathy are needed because current surgical strategies have limitations5. Entero-neuropathy results from enteric nervous system dysfunction due to incomplete colonization of the distal intestine by neural crest-derived cells. Read More

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Elp1 is required for development of visceral sensory peripheral and central circuitry.

Dis Model Mech 2022 Apr 28. Epub 2022 Apr 28.

Department of Microbiology and Cell Biology, Montana State University, Bozeman, MT 59717, USA.

Cardiovascular instability and a blunted respiratory drive in hypoxic conditions, are hallmark features of the genetic sensory and autonomic neuropathy, familial dysautonomia (FD). FD results from a mutation in the gene ELP1, whose encoded protein is a scaffolding subunit of the six subunit Elongator complex. In mice, we and others have shown that Elp1 is essential for the normal development of neural crest derived-dorsal root ganglia (DRG) sensory neurons. Read More

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[Small fiber neuropathy diagnosis].

Rev Med Suisse 2022 Apr;18(779):803-807

Centre de référence pour les maladies neuromusculaires AOC, CHU Hôtel-Dieu, 1 Pl. Alexis-Ricordeau, 44000 Nantes, France.

Small fiber neuropathies affect small, poorly myelinated sensory Aδ and amyelinated C autonomic fibers. Neuropathic pain is often the main symptom. Positive diagnosis is based on the presence of deficient thermo-algesic sensory signs and/or dysautonomic signs with normal neurography. Read More

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Association of heart rate variability with progression of retinopathy among adults with type 2 diabetes.

Diabet Med 2022 Apr 25:e14857. Epub 2022 Apr 25.

Department of Medicine, Division of Endocrinology, Diabetes & Metabolism, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

Aim: We evaluated the associations of heart rate variability (HRV) with incident vision-threatening retinopathy and retinopathy progression among adults with type 2 diabetes.

Methods: Participants recruited to the ACCORD (Action to Control Cardiovascular Risk in Diabetes) study with HRV measures at baseline were analysed. HRV measures included standard deviation of all normal-to-normal intervals (SDNN) and root mean square of successive differences between normal-to-normal intervals (rMSSD). Read More

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Intrathecal Injection of Mesenchymal Stromal Cell Cultured on 3D Fiber Ameliorates Multiple Organ Damage in Murine Lupus.

Stem Cells Transl Med 2022 Apr 25. Epub 2022 Apr 25.

Department of Anatomy, Sapporo Medical University School of Medicine, Sapporo, Japan.

Up to 60% of patients with systemic lupus erythematosus (SLE) experience autonomic symptom. Sympathetic nervous system damage can cause dysfunction of the bone marrow that activates inflammatory cells, potentially causing multiple organ damage. We hypothesized that sympathetic nervous system damage would induce bone marrow dysfunction with multiple organ damage in SLE, and that multiple organ damage could be improved by therapy targeting the nervous system. Read More

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Novel Application of Multiscale Cross-Approximate Entropy for Assessing Early Changes in the Complexity between Systolic Blood Pressure and ECG R-R Intervals in Diabetic Rats.

Entropy (Basel) 2022 Mar 29;24(4). Epub 2022 Mar 29.

School of Medicine, Tzu Chi University, Hualien 970374, Taiwan.

Cardiac autonomic neuropathy (CAN) is a common complication of diabetes mellitus, and can be assessed using heart rate variability (HRV) and the correlations between systolic blood pressure (SBP) and ECG R-R intervals (RRIs), namely baroreflex sensitivity (BRS). In this study, we propose a novel parameter for the nonlinear association between SBP and RRIs based on multiscale cross-approximate entropy (MS-CXApEn). Sixteen male adult Wistar Kyoto rats were equally divided into two groups: streptozotocin-induced diabetes and age-matched controls. Read More

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Characteristics of patients with autonomic dysfunction in the Transthyretin Amyloidosis Outcomes Survey (THAOS).

Amyloid 2022 Apr 22:1-9. Epub 2022 Apr 22.

Pfizer Inc, Groton, CT, USA.

Background: Autonomic dysfunction is common in transthyretin amyloidosis (ATTR amyloidosis), but its frequency, characteristics, and quality-of-life (QoL) impact are not well understood.

Methods: The Transthyretin Amyloidosis Outcomes Survey (THAOS) is an ongoing, global, longitudinal survey of patients with ATTR amyloidosis, including patients with inherited (ATTRv) and wild-type (ATTRwt) disease and asymptomatic patients with mutations (ClinicalTrials.gov: NCT00628745). Read More

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Correlation between skin advanced glycation end products and cardiac autonomic neuropathy among subjects with type 2 diabetes mellitus.

Exp Clin Endocrinol Diabetes 2022 Apr 21. Epub 2022 Apr 21.


Advanced glycation end products (AGEs) are frequently increased in the skin of subjects with type 2 diabetes mellitus (T2DM). This study aimed to examine the correlation of AGEs with cardiac autonomic neuropathy (CAN) in T2DM. To this aim, 132 participants (88 men) with a mean age of 64. Read More

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