184,558 results match your criteria Autonomic Dysreflexia in Spinal Cord Injury


Posttraumatic Headache.

Authors:
Brigid Dwyer

Semin Neurol 2018 Dec 6;38(6):619-626. Epub 2018 Dec 6.

Department of Neurology, Boston University School of Medicine, Boston, Massachusetts.

Posttraumatic headaches are among the most challenging complaints after mild traumatic brain injury (mTBI). They are a debilitating problem experienced by patients after TBI of all severities. Up to 90% of mild TBI patients experience headache, particularly if female and with a premorbid history of primary headache. Read More

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December 2018
3 Reads

Cluster Headache and Other Trigeminal Autonomic Cephalalgias.

Authors:
Brian E McGeeney

Semin Neurol 2018 Dec 6;38(6):603-607. Epub 2018 Dec 6.

Department of Neurology, Boston University School of Medicine, Boston, Massachusetts.

The trigeminal autonomic cephalalgias are a group of distinct primary headache disorders that share common characteristics of strict unilateral headache often accompanied by unilateral cranial autonomic features. Cluster headache is the most well-known example, but other than neurologists, practitioners often have limited familiarity with these disorders and treatment options. Delays in diagnosis are typical and treatment options remain suboptimal, associated with limited scientific research into these brain disorders. Read More

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December 2018
2 Reads

Heart Rate Variability Predicts Older Adults' Avoidance of Negativity.

J Gerontol B Psychol Sci Soc Sci 2018 Dec 6. Epub 2018 Dec 6.

Department of Psychology, University of Warwick, Coventry, UK.

Objectives: The ability to produce situation-appropriate cognitive and emotional responses is dependent on autonomic nervous system (ANS) functionality. Heart rate variability (HRV) is an index of ANS functionality, and resting HRV levels have been associated with cognitive control and inhibitory capacity in young adults, particularly when faced with emotional information. As older adults' greater preference for positive and avoidance of negative stimuli (positivity effect) is thought to be dependent on cognitive control, we hypothesized that HRV could predict positivity-effect magnitude in older adults. Read More

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December 2018
2 Reads

Cardiac parasympathetic activity and ventricular diastolic interactions in individuals with spinal cord injury.

Spinal Cord 2018 Dec 5. Epub 2018 Dec 5.

Department of Kinesiology, Brock University, 1812 Sir Isaac Brock Way, St. Catharines, L2S 3A1, ON, Canada.

Study Design: Cohort cross-sectional study.

Objective: To investigate the relationship between cardiac vagal activity and left ventricular filling at rest and during vagal stimulation, via the cold face test (CFT), in individuals with spinal cord injury (SCI).

Setting: University-based laboratory at Brock University, St. Read More

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December 2018

Autonomic dysfunction in programmed hypertension.

J Hum Hypertens 2018 Dec 5. Epub 2018 Dec 5.

School of Medical Sciences & Bosch Institute, The University of Sydney, Sydney, Australia.

Hypertension is an important modifiable risk factor for cardiovascular diseases. Its high prevalence, combined with the significant morbidity and mortality associated with secondary complications, make it a major public health concern. Despite decades of research, over 95% of all cases of hypertension remain of unknown etiology, necessitating that treatments target the established symptoms and not the cause. Read More

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December 2018
1 Read

Recognition, Assessment, and Pharmacotherapeutic Treatment of Alcohol Withdrawal Syndrome in the Intensive Care Unit.

Crit Care Nurs Q 2019 Jan/Mar;42(1):12-29

Department of Pharmacy Services, UC Health-University of Cincinnati Medical Center, Ohio (Drs Foertsch, Winter, Droege, and Ernst); University of Cincinnati James L. Winkle College of Pharmacy, Ohio (Drs Foertsch, Winter, Rhoades, Martin, Droege, and Ernst); Department of Pharmacy Services, The Christ Hospital Health Network, Cincinnati, Ohio (Dr Rhoades); and Department of Pharmacy Services, St Elizabeth Healthcare, Edgewood, Kentucky (Dr Martin).

Alcohol withdrawal syndrome (AWS) is a complex neurologic disorder that develops after an acute reduction in or cessation of chronic alcohol consumption that alters neurotransmitter conduction. The incidence of AWS in the intensive care unit varies, but has been associated with poor outcomes. This is primarily driven by downregulation of gamma-aminobutyric acid (GABA) leading to autonomic excitability and psychomotor agitation. Read More

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December 2018

Unconstrained Estimation of HRV Indices after Removing Respiratory Influences from Heart Rate.

IEEE J Biomed Health Inform 2018 Dec 3. Epub 2018 Dec 3.

Objective: This paper proposes an approach to better estimate the sympathovagal balance (SB) and the respiratory sinus arrhythmia (RSA) after separating respiratory influences from the heart rate (HR).

Methods: The separation is performed using orthogonal subspace projections and the approach is first tested using simulated HR and respiratory signals with different spectral properties. Then, RSA and SB are estimated during autonomic blockade and stress using the proposed approach and the classical heart rate variability (HRV) analysis. Read More

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December 2018

Loss of m A on FAM134B promotes adipogenesis in porcine adipocytes through m A-YTHDF2-dependent way.

IUBMB Life 2018 Dec 2. Epub 2018 Dec 2.

College of Animal Sciences, Key Laboratory of Animal Nutrition & Feed Sciences, Ministry of Agriculture, Zhejiang Provincial Laboratory of Feed and Animal Nutrition, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.

N -methyladenosine (m A) mRNA modification plays an important role in adipogenesis, but its role on single gene remains unexplored. Family with Sequence Similarity 134, Member B (FAM134B) is a cis-Golgi transmembrane protein that known to be necessary for the long-term survival of nociceptive and autonomic ganglion neurons. Recent work has shown that FAM134B plays a pivotal role in lipid homeostasis and was identified as its significant m A level difference between Chinese local Jinhua pigs and Landrace through RNA-sequence. Read More

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December 2018

Regulation of Sensory Nerve Conduction Velocity (SCV) of Human Bodies Responding to Annual Temperature Variations in Natural Environments.

Indoor Air 2018 Nov 30. Epub 2018 Nov 30.

Joint International Research Laboratory of Green Buildings and Built Environments (Ministry of Education), Chongqing University, Chongqing, 400045, China.

The extensive research interests in environmental temperature can be linked to human productivity/performance as well as comfort and health; while the mechanisms of physiological indices responding to temperature variations remain incompletely understood. This study adopted a physiological sensory nerve conduction velocity (SCV) as a temperature-sensitive biomarker to explore the thermoregulatory mechanisms of human responding to annual temperatures. The measurements of subjects' SCV (over 600 samples) were conducted in a naturally ventilated environment over all four seasons. Read More

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November 2018

Skin nerve α-synuclein deposits in Parkinson's disease and other synucleinopathies: a review.

Authors:
Donadio Vincenzo

Clin Auton Res 2018 Nov 30. Epub 2018 Nov 30.

IRCCS Istituto Delle Scienze Neurologiche di Bologna (Italy), UOC Clinica Neurologica, Via Altura 3, 40139, Bologna, Italy.

Purpose: The in vivo diagnosis of synucleinopathies is an important research aim since clinical diagnostic criteria show low accuracy. The skin innervation, especially the autonomic subdivision, is a useful region to search for abnormal α-syn aggregates in synucleinopathies since the peripheral sympathetic nerves can be the earliest-affected neural region and autonomic symptoms may precede the classical symptoms of these disorders.

Methods: The major advantages of skin biopsy as an in vivo diagnostic tool for synucleinopathies are that it is an inexpensive and easy-to-perform technique requiring only limited facilities, and that it is repeatable in long-term studies as it causes only minor discomfort to the patient. Read More

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November 2018

Glial Activation and Expression of the Serotonin Transporter in Chronic Fatigue Syndrome.

Front Psychiatry 2018 16;9:589. Epub 2018 Nov 16.

Department of Neuroinflammation and Brain Fatigue Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Fatigue is commonly reported in a variety of illnesses and has major impact on quality of life. Chronic fatigue syndrome (CFS) is a debilitating syndrome of unknown etiology. The clinical symptoms include problems in neuroendocrine, autonomic, and immune systems. Read More

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November 2018

[Obstructive sleep apnea-hypopnea and stroke].

Medicina (B Aires) 2018 ;78(6):427-435

Departamento de Medicina, Universitat Autónoma de Barcelona, Barcelona, España.

Stroke, one of the main causes of disability and death worldwide, is frequently associated to the obstructive sleep apnea-hypopnea syndrome. This sleep disorder has been demonstrated to be an independent risk factor for stroke, and therefore its investigation and treatment has been recommended for patients with stroke. Mechanisms relating these two clinical disorders include: oxidative stress, cerebral blood flow alterations, autonomic dysfunction, and hypercoagulability, as well as patent foramen ovale, blood pressure, and heart rhythm disorders. Read More

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January 2018

Reduced professional efficacy is associated with a blunted salivary alpha-amylase awakening response.

Physiol Behav 2018 Nov 29;199:292-299. Epub 2018 Nov 29.

School of Psychology and Public Health, La Trobe University, Bundoora, VIC 3086, Australia. Electronic address:

The job demands-resources model (JD-R) has shown an ability to predict worker engagement and exhaustion, yet to our knowledge, research has not been conducted that assesses the JD-R model with physiological indicators of chronic stress and burnout. Using the JD-R model, we assessed if occupational stress and burnout were related to dysregulated cortisol and salivary alpha-amylase awakening responses (sAA-AR). Professional apprentice jockeys comprising of males (n = 14) and females (n = 18) provided morning saliva samples and completed self-report measures relating to job demands and resources, burnout, and perceived mental and physical health. Read More

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November 2018

Exploring the pre-morbid contexts in which central sensitisation developed in individuals with non-specific chronic low back pain. A qualitative study.

Braz J Phys Ther 2018 Nov 8. Epub 2018 Nov 8.

Faculty of Health, Psychology and Social Care, Manchester Metropolitan University, Manchester, Birley Campus, Manchester, United Kingdom.

Background: Central sensitisation pain is a predominant mechanism in a proportion of individuals with non-specific chronic low back pain and is associated with poor outcomes. It is proposed that the pre-morbid experiences and contexts may be related to the development of central sensitisation.

Objectives: The objective of this study was to explore the pre-morbid experiences and personal characteristics of participants with central sensitisation pain from a non-specific chronic low back pain population. Read More

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November 2018

Recursive model identification for the analysis of the autonomic response to exercise testing in Brugada syndrome.

Artif Intell Med 2018 Nov 28. Epub 2018 Nov 28.

Univ Rennes, CHU Rennes, Inserm, LTSI UMR 1099, F-35000 Rennes, France.

This paper proposes the integration and analysis of a closed-loop model of the baroreflex and cardiovascular systems, focused on a time-varying estimation of the autonomic modulation of heart rate in Brugada syndrome (BS), during exercise and subsequent recovery. Patient-specific models of 44 BS patients at different levels of risk (symptomatic and asymptomatic) were identified through a recursive evolutionary algorithm. After parameter identification, a close match between experimental and simulated signals (mean error = 0. Read More

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November 2018
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Relation of Hepatic Fibrosis in Nonalcoholic Fatty Liver Disease to Left Ventricular Diastolic Function and Exercise Tolerance.

Am J Cardiol 2018 Nov 6. Epub 2018 Nov 6.

Division of Gastroenterology - Hepatology Division, Virginia Commonwealth University, Richmond, Virginia.

The purpose of this study was to determine the relation between liver histology, exercise tolerance, and diastolic function in patients with nonalcoholic fatty liver disease (NAFLD). Myocardial remodeling and diastolic dysfunction have been associated with NAFLD. However, its physiological impact and relationship to the histological severity of NAFLD is not known. Read More

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November 2018

Is metabolic syndrome related to exercise cardiac autonomic modulation in obese adults?

Auton Neurosci 2018 Nov 14. Epub 2018 Nov 14.

Department of Physical Education, Center of Health Sciences, State University of Maringa, Maringa, Brazil.

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November 2018

Acute phenibut withdrawal: A comprehensive literature review and illustrative case report.

Bosn J Basic Med Sci 2018 Dec 3. Epub 2018 Dec 3.

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.

Phenibut is a glutamic acid derivative with activity on the γ-aminobutyric acid (GABA) B and A, and β-phenethylamine receptors. It is prescribed in former Communist Bloc countries for anxiolysis and related psychiatric disorders. It can be easily obtained in Western countries, and is thought to have abuse potential. Read More

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December 2018
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Altered A-Type Potassium Channel Function in the Nucleus Tractus Solitarius in Acquired Temporal Lobe Epilepsy.

J Neurophysiol 2018 Dec 5. Epub 2018 Dec 5.

Neuroscience, University of Kentucky College of Medicine, United States.

Sudden unexpected death in epilepsy (SUDEP) is among the leading causes of death in people with epilepsy. Individuals with temporal lobe epilepsy (TLE) have a high risk for SUDEP because the seizures are often medically intractable. Neurons in the nucleus tractus solitarius (NTS) have been implicated in mouse models of SUDEP and play a critical role in modulating cardiorespiratory and autonomic output. Read More

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December 2018
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An updated normative data-set from the Autonomic Reflex Screen representative of Southwestern Ontario.

Can J Physiol Pharmacol 2018 Dec 5. Epub 2018 Dec 5.

London Health Sciences Centre, 10033, Clinical Neurological Sciences, London, Ontario, Canada.

Background: In evaluating autonomic dysfunction, the autonomic reflex screen (ARS) is an established set of standardized tests to evaluate the presence and severity of autonomic dysfunction. Our laboratory previously reported normative data on 121 healthy individuals; however, the sample size in older individuals was reduced compared to other age groups. Therefore, the objective of the current study was to provide updated normative values representative of young, middle aged and older individuals from Southwestern Ontario. Read More

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December 2018

Klotho deficiency aggravates sepsis-related multiple organ dysfunction.

Am J Physiol Renal Physiol 2018 Dec 5. Epub 2018 Dec 5.

Internal Medicine - Nephrology, University of Sao Paulo School of Medicine, Brazil.

Sepsis-induced organ failure is characterized by a massive inflammatory response and oxidative stress. Acute kidney injury (AKI) occurs in approximately half of patients in septic shock, and the mortality associated with sepsis-induced AKI is unacceptably high. Klotho is a protein expressed by renal cells and has anti-senescence properties. Read More

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December 2018

Selective ablation of ligament of Marshall inhibits ventricular arrhythmias during acute myocardial infarction: Possible mechanisms.

J Cardiovasc Electrophysiol 2018 Dec 5. Epub 2018 Dec 5.

Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.

Introduction: Our recent study found that selective ablation of the distal part of the ligament of Marshall (LOM ) could suppress ventricular arrhythmias (VAs) during acute myocardial infarction (AMI). This study was to investigate the possible underlying mechanisms.

Methods: Dogs were randomly subjected into the sham operated group (SO, n=6), AMI group (AMI, n=8) and the group undergoing LOM ablation ahead of AMI (LOMD+AMI, n=8). Read More

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December 2018

Utility of lacrimal caruncle infrared thermography when monitoring alterations in autonomic activity in healthy humans.

Eur J Appl Physiol 2018 Dec 4. Epub 2018 Dec 4.

Extracellular Vesicles and the Endothelial Dynamics Laboratory, Department of Biological Sciences, Thompson Rivers University, Kamloops, BC, V2C 0C8, Canada.

Purpose: Physiological markers that estimate sympathetic activation may be used to infer pain and stress in humans. To date, effective reproducible methods are invasive and pose an undesired risk to participants. Previous work in animal models has used infrared thermography to measure the temperature of the lacrimal caruncle region and may be a promising method for measuring stress and pain non-invasively. Read More

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December 2018

Clinical Rating Scales for Urinary Symptoms in Parkinson Disease: Critique and Recommendations.

Mov Disord Clin Pract 2018 Sep-Oct;5(5):479-491. Epub 2018 Oct 25.

Department of Neurological Services Rush University School of Medicine Chicago IL USA.

Background: The prevalence of lower urinary tract symptoms (LUTS) is high in Parkinson's disease (PD). These problems negatively affect quality of life and include both storage and voiding problems. The International Parkinson and Movement Disorder Society established a task force to review clinical rating scales/questionnaires for the assessment of urinary symptoms in PD. Read More

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October 2018
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Diagnostic Validation for Participants in the Washington State Parkinson Disease Registry.

Parkinsons Dis 2018 1;2018:3719578. Epub 2018 Nov 1.

Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA.

Background: The Washington State Parkinson Disease Registry (WPDR) was created to facilitate recruitment for Parkinson's disease (PD) research studies conducted in the Pacific Northwest. The success of registries that rely on self-report is dependent on the accuracy of the information provided by participants, particularly diagnosis.

Objective And Methods: Our goal was to assess diagnostic accuracy within the WPDR cohort. Read More

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November 2018
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Voice Stress Analysis: A New Framework for Voice and Effort in Human Performance.

Front Psychol 2018 20;9:1994. Epub 2018 Nov 20.

VIPER Research Unit, LIFE Department, Royal Military Academy, Brussels, Belgium.

People rely on speech for communication, both in a personal and professional context, and often under different conditions of physical, cognitive and/or emotional load. Since vocalization is entirely integrated within both our central (CNS) and autonomic nervous system (ANS), a mounting number of studies have examined the relationship between voice output and the impact of stress. In the current paper, we will outline the different stages of voice output, i. Read More

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November 2018
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Regional Cardiac Sympathetic Nervous System Evaluation Using 123I-mIBG SPECT in Patients with Heart Failure.

J Med Imaging Radiat Sci 2018 Dec 19;49(4):397-405. Epub 2018 Jun 19.

School of Dentistry & Health Sciences, Charles Sturt University, Wagga Wagga, Australia; Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia; Cardiac Health Institute, Sydney, Australia.

Background: Heart failure (HF) involves both mechanical and autonomic nervous system dysfunction that can lead to sudden cardiac death. In the failing human heart, there is increased release of norepinephrine from neurons and reduced uptake. Iodine-123-labeled metaiodobenzylguanidine (123I-mIBG) demonstrates reduced global uptake and increased washout associated with increased mortality in HF. Read More

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December 2018

[Analysis of influencing factors the postoperative axial symptoms of cervical single open-door laminoplasty].

Zhongguo Gu Shang 2018 Nov;31(11):1022-1026

Zhejiang Provincial Tongde Hospital, Hangzhou 310012, Zhejiang, China;

Objective: To explore the influencing factors and possible mechanism of axial symptoms(AS) after C₃-C₇ single open-door laminoplasty in patients with chronic compression cervical myelopathy.

Methods: The clinical data of 32 patients with multi-segment chronic compression cervical cord disease treated by C₃-C₇ single open-door laminectomy from May 2012 to July 2016 were retrospectively analyzed. Including cervical spondylotic myelopathy of 14 cases, developmental cervical stenosis complicated with cervical myelopathy of 8 cases, ossification of posterior longitudinal ligament(OPLL) of 10 cases. Read More

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November 2018

Could Alcohol Abuse Drive Intimate Partner Violence Perpetrators' Psychophysiological Response to Acute Stress?

Int J Environ Res Public Health 2018 Dec 3;15(12). Epub 2018 Dec 3.

Department of Psychobiology, University of Valencia, 46010 Valencia, Spain.

Proactively aggressive individuals have been shown to present a different pattern of autonomic nervous system (ANS) dysregulation from that of individuals characterized by reactive violence. Although attempts have been made to classify intimate partner violence (IPV) perpetrators based on ANS reactivity to acute stress, subsequent studies have failed to replicate this classification. Notably, the proposed classification neglected the role of chronic alcohol abuse in ANS dysregulation and the fact that this dysregulation entails an abnormal stress response. Read More

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December 2018

Role of the autonomic nervous system in osteoarthritis.

Best Pract Res Clin Rheumatol 2017 Oct;31(5):661-675

Rheumatology Department, Saint-Antoine Hospital, Assistance Publique - Hôpitaux de Paris (AP-HP), Sorbonne Universités, INSERM UMR S_938, DHU i2B, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, Inserm UMR S_938, DHU i2B, Saint-Antoine Service de Rhumatologie, Paris, France. Electronic address:

Joint homeostasis is affected by local and systemic processes. Catecholaminergic and cholinergic fibers innervate the synovium, trabecular bone, and periosteum. Several studies have investigated the involvement of the autonomic nervous system (ANS) in joint homeostasis and the pathophysiology of osteoarthritis (OA). Read More

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October 2017
2 Reads

Heart rate variability changes in major depressive disorder during sleep: Fractal index correlates with BDI score during REM sleep.

Psychiatry Res 2018 Nov 12;271:291-298. Epub 2018 Nov 12.

Department of Biomedical Engineering, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea; Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University, Seoul 03080, Republic of Korea. Electronic address:

We investigated the relationship between autonomic nervous system activity during each sleep stage and the severity of depressive symptoms in patients with major depressive disorder (MDD) and healthy control subjects. Thirty patients with MDD and thirty healthy control subjects matched for sex, age, and body mass index completed standard overnight polysomnography. Depression severity was assessed using the Beck Depression Inventory (BDI). Read More

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November 2018
5 Reads

High thoracic sympathetic block improves coronary microcirculation disturbance in rats with chronic heart failure.

Microvasc Res 2018 Dec 1;122:94-100. Epub 2018 Dec 1.

Department of Cardiac Ultrasound, the First Affiliated Hospital of Harbin Medical University, Harbin, China.

Introduction: Coronary microcirculation disturbance plays an important role in chronic heart failure (CHF). High thoracic sympathetic block (HTSB) is effective to treat CHF, but its impact on coronary microcirculation is unclear.

Methods: Forty male Wistar rats were subcutaneously injected with isoproterenol (340 mg/kg) for 2 days. Read More

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December 2018
1 Read

Autoimmune encephalitis with psychosis: Warning signs, step-by-step diagnostics and treatment.

World J Biol Psychiatry 2018 Dec 4:1-25. Epub 2018 Dec 4.

e Department of Psychiatry and Psychotherapy , Ludwig-Maximilians-University Munich , Munich , Germany.

Objectives: Despite intensive research, schizophrenia and schizoaffective disorders continue to be theoretical constructs that describe clinical syndromes and no pathophysiologically defined diseases. Moreover, there are no clear biomarkers at hand. Therefore, these diagnoses are still set up based on clinical ICD-10 / DSM-5 criteria and the exclusion of alcohol- / drug-associated, systemic or other brain organic causes. Read More

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December 2018
1 Read

Impact of supportive therapy modalities on heart rate variability in cancer patients - a systematic review.

Disabil Rehabil 2018 Dec 4:1-8. Epub 2018 Dec 4.

a Department of Physical Medicine, Rehabilitation and Occupational Medicine , Medical University of Vienna, Vienna , Austria.

Purpose: To systematically review literature for interventional studies and their impact on autonomic dysfunction assessed by heart rate variability in cancer patients.

Methods: Research was conducted using the databases Medline/Pubmed, Scopus, and Web of science from their inception to October 2017. Original articles with an interventional design that reported changes in at least one heart rate variability parameter as outcome parameter were included and described. Read More

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December 2018
1 Read

Pulmonary Vein Ganglia Are Remodeled in the Diabetic Heart.

J Am Heart Assoc 2018 Dec;7(23):e008919

2 Department of Molecular Pharmacology and Physiology Morsani College of Medicine University of South Florida Tampa FL.

Background Cardiac autonomic neuropathy is thought to cause adverse cardiovascular effects in diabetes mellitus. Pulmonary vein ganglia ( PVG ), which have been implicated in normal and abnormal heart rhythm regulation, have not been fully investigated in type 1 diabetes mellitus (T1D). We examined the functional and anatomical effects of T1D on PVG and studied the details of T1D-induced remodeling on the PVG structure and function. Read More

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December 2018
1 Read

Revisiting the Concept of Subjective Tolerability to Antipsychotic Medications in Schizophrenia and its Clinical and Research Implications: 30 Years Later.

Authors:
A George Awad

CNS Drugs 2018 Dec 3. Epub 2018 Dec 3.

Professor Emeritus, Department of Psychiatry and the Institute of Medical Science, Humber River Hospital, University of Toronto, 1235 Wilson Avenue, Toronto, ON, M3M 0B2, Canada.

Schizophrenia is a long-term psychiatric disorder that impacts important mental functions and requires indefinite treatment, as well as psychosocial and economic support. The introduction of chlorpromazine, the first antipsychotic, and the subsequent development of a long list of similar dopamine-blocking antipsychotic medications, has changed the treatment of schizophrenia as medications have become the cornerstone of clinical management. The enthusiasm that greeted the introduction of antipsychotics was soon tempered by the realisation that they induced significant side effects, such as extrapyramidal and autonomic symptoms. Read More

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December 2018
1 Read

Low-pressure micro-mechanical re-adaptation device sustainably and effectively improves locomotor recovery from complete spinal cord injury.

Commun Biol 2018 26;1:205. Epub 2018 Nov 26.

1Molecular Neurobiology Laboratory, Department of Neurology, Heinrich-Heine-University Medical Centre Düsseldorf, Moorenstr. 5, 40225 Düsseldorf, Germany.

Traumatic spinal cord injuries result in impairment or even complete loss of motor, sensory and autonomic functions. Recovery after complete spinal cord injury is very limited even in animal models receiving elaborate combinatorial treatments. Recently, we described an implantable microsystem (microconnector) for low-pressure re-adaption of severed spinal stumps in rat. Read More

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November 2018
1 Read

High-Intensity Exercise Mitigates Cardiovascular Deconditioning During Long-Duration Bed Rest.

Front Physiol 2018 19;9:1553. Epub 2018 Nov 19.

Charité-Universitätsmedizin Berlin, Institute of Physiology, Center for Space Medicine and Extreme Environments Berlin, Berlin, Germany.

Head-down-tilt bed rest (HDT) mimics the changes in hemodynamics and autonomic cardiovascular control induced by weightlessness. However, the time course and reciprocal interplay of these adaptations, and the effective exercise protocol as a countermeasure need further clarification. The overarching aim of this work (as part of a European Space Agency sponsored long-term bed rest study) was therefore to evaluate the time course of cardiovascular hemodynamics and autonomic control during prolonged HDT and to assess whether high-intensity, short-duration exercise could mitigate these effects. Read More

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November 2018
3 Reads

Stroke-heart syndrome: clinical presentation and underlying mechanisms.

Lancet Neurol 2018 Dec 26;17(12):1109-1120. Epub 2018 Oct 26.

Klinik und Hochschulambulanz für Neurologie, Charité-Universitätsmedizin Berlin, Berlin, Germany; Berlin Institute of Health, Berlin, Germany; German Centre for Cardiovascular Research, Deutsches Zentrum für Herz-Kreislauf-Forschung, partner site Berlin, Berlin, Germany; German Center for Neurodegenerative Disease, Deutsches Zentrum für Herz-Kreislauf-Forschung, partner site Berlin, Berlin, Germany. Electronic address:

Cardiac complications are a frequent medical problem during the first few days after an ischaemic stroke, and patients present with a broad range of symptoms including myocardial injury, cardiac dysfunction, and arrhythmia, with varying overlap between these three conditions. Evidence from clinical and neuroimaging studies and animal research suggests that these cardiac disturbances share the same underlying mechanisms. Although the exact cascade of events has yet to be elucidated, stroke-induced functional and structural alterations in the central autonomic network, with subsequent dysregulation of normal neural cardiac control, are the assumed pathophysiology. Read More

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December 2018
1 Read

Electro convulsive therapy: Modification of its effect on the autonomic nervous system using anti-cholinergic drugs.

Psychiatry Res 2018 Nov 23;271:239-246. Epub 2018 Nov 23.

Institute of Clinical Medicine, Copenhagen University, Copenhagen, Denmark; Psychiatric Centre Copenhagen, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark.

The antidepressant efficacy of electroconvulsive therapy (ECT) is correlated to the quality of the seizure as measured by EEG but has also been linked to the magnitude of changes in hemodynamic variables. Muscarinic receptor antagonists are frequently used in the treatment, and are known to affect the hemodynamic response. We hypothesized that atropine and glycopyrrolate alter the hemodynamic and autonomic hormonal response to ECT. Read More

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November 2018

Cardioautonomic responses to acute ingestion of ice water and its correlation to body mass index.

J Basic Clin Physiol Pharmacol 2018 Nov 30. Epub 2018 Nov 30.

Department of Physiology, SDM College of Medical Sciences and Hospital, Sattur Dharwad 580009, Karnataka, India, Phone: +9480548618.

Background A significant relationship has been documented in the literature between the autonomic nervous system imbalance and cardiovascular mortality. In patients with autonomic failure, water ingestion has been shown to increase blood pressure (BP), induce bradycardia, and cause low heart rate variability (HRV). A few studies showed the altered HRV as an acute effect of ice water intake in healthy subjects. Read More

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November 2018

Neurosurgical issues of bariatric surgery: A systematic review of the literature and principles of diagnosis and treatment.

Clin Neurol Neurosurg 2018 Nov 13;176:34-40. Epub 2018 Nov 13.

Neurosurgery Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Italy.

Bariatric surgery is gaining popularity as the treatment of choice of morbid obesity since this condition is constantly increasing over the last decades. Several complications have emerged as the number of surgeries and follow-up data increase. No systematic review of the neurosurgery-related potential complications has been performed to date. Read More

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November 2018

[Experience with mexidol in neurological practice].

Zh Nevrol Psikhiatr Im S S Korsakova 2018 ;118(10):97-107

Federal State Autonomous Institution 'National Medical Research Center for Neurosurgery named after Academician N.N. Burdenko' of the Ministry of Health of the Russian Federation, Moscow, Russia.

Antihypoxic, antioxidant and nootropic effects of mexidol contribute to the improvement of patients with cerebrovascular pathology. The results of clinical studies show that the sequential scheme of using mexidol (first i.v. Read More

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January 2018
4 Reads

[Transthyretin familial amyloid polyneuropathy].

Zh Nevrol Psikhiatr Im S S Korsakova 2018 ;118(10):82-89

Federal State Budget Educational Establishment of Higher Education Nizhny Novgorod State Medical Academy of the Ministry of Public Health of the Russian Federation, Nizhny Novgorod, Russia.

Transthyretin family amyloid polyneuropathy (TTR-FAP) is a progressive, ultimately fatal disease. It manifests itself primarily with sensory, motor and autonomic polyneuropathy and/or cardiomyopathy and is caused by extracellular deposition of insoluble amyloid fibrils in the endoneurium. The cause of TTR-FAP is the mutation in the gene encoding transthyretin, more than 100 types of mutations are known. Read More

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January 2018

The biological embedding of neonatal stress exposure: A conceptual model describing the mechanisms of stress-induced neurodevelopmental impairment in preterm infants.

Res Nurs Health 2018 Nov 29. Epub 2018 Nov 29.

The Ohio State University College of Nursing, Columbus, Ohio.

The biological embedding of early life stress exposure may result in life-long neurodevelopmental impairment in preterm infants. Infants hospitalized in the neonatal intensive care unit are exposed to significant experiential, environmental, and physiologic stressors over the course of their extended hospitalization. Stress exposure during the sensitive period of brain development may alter biological processes, including functioning of the immune system, the autonomic nervous system, and the hypothalamic-pituitary-adrenal axis as well as gene expression. Read More

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November 2018

Role of autonomic nervous system in atrial fibrillation.

Int J Cardiol 2018 Nov 18. Epub 2018 Nov 18.

Centre for Heart Rhythm Disorders (CHRD), South Australian Health and Medical Research Institute (SAHMRI), University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia.

Atrial fibrillation is the most common sustained arrhythmia and is associated with significant morbidity and mortality. The autonomic nervous system has a significant role in the milieu predisposing to the triggers, perpetuators and substrate for atrial fibrillation. It has direct electrophysiological effects and causes alterations in atrial structure. Read More

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November 2018
3 Reads

A novel nonsense mutation in WNK1/HSN2 associated with sensory neuropathy and limb destruction in four siblings of a large Iranian pedigree.

BMC Neurol 2018 Nov 29;18(1):195. Epub 2018 Nov 29.

Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Hereditary sensory and autonomic neuropathy type 2 (HSAN2) is an autosomal recessive disorder with predominant sensory dysfunction and severe complications such as limb destruction. There are different subtypes of HSAN2, including HSAN2A, which is caused by mutations in WNK1/HSN2 gene.

Methods: An Iranian family with four siblings and autosomal recessive inheritance pattern whom initially diagnosed with HSAN2 underwent whole exome sequencing (WES) followed by segregation analysis. Read More

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November 2018

Diabetic Neuropathic Cachexia in a Young Woman.

Korean J Fam Med 2018 Nov 30. Epub 2018 Nov 30.

School of Medical Science, Universiti Sains Malaysia Health Campus, Kubang Kerian, Malaysia.

Profound weight loss with painful symmetrical peripheral neuropathy in diabetic patients was first described as diabetic neuropathic cachexia more than 4 decades ago. It is a distinct type of diabetic peripheral neuropathy that occurs in the absence of other microvascular and autonomic complications of diabetes. The mechanism and precipitating cause are unknown. Read More

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November 2018
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