186,260 results match your criteria Autonomic & autacoid pharmacology[Journal]


Resting-state Functional Connectivity Between Centromedial Amygdala and Insula as Related to Somatic Symptoms in Depressed Patients: A Preliminary Study.

Psychosom Med 2019 Apr 18. Epub 2019 Apr 18.

Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.

Objective: Somatic symptoms are prevalent in patients with depression. The centromedial amygdala (CMA) is a key brain region that mediates autonomic and somatic responses. Abnormal function in the CMA may contribute to the development of somatic symptoms in depressed patients. Read More

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http://dx.doi.org/10.1097/PSY.0000000000000697DOI Listing

Axon degeneration: mechanistic insights lead to therapeutic opportunities for the prevention and treatment of peripheral neuropathy.

Authors:
Aaron DiAntonio

Pain 2019 May;160 Suppl 1:S17-S22

Department of Developmental Biology, Washington University Medical School Saint Louis, Saint Louis, MO, United States.

Peripheral neuropathy is the most common neurodegenerative disease affecting hundreds of millions of patients worldwide and is an important cause of chronic pain. Typical peripheral neuropathies are characterized by dysesthesias including numbness, crawling skin, a sensation of "pins and needles," and burning and stabbing pain. In addition, peripheral neuropathy can affect the motor and autonomic systems leading to symptoms such as weakness, constipation, and dysregulation of blood pressure. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001528DOI Listing

[Research advances of autonomic nervous system in the regulation of cardiac inflammation].

Sheng Li Xue Bao 2019 Apr;71(2):225-234

Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital; NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education; Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing 100191, China.

The autonomic nervous system consists of the sympathetic nervous system and the parasympathetic nervous system. These two systems control the heart and work in a reciprocal fashion to modulate myocardial energy metabolism, heart rate as well as blood pressure. Multiple cardiac pathological conditions are accompanied by autonomic imbalance, characterized by sympathetic overactivation and parasympathetic inhibition. Read More

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[Recent progress on obesity-induced myocardial remodeling and its possible mechanism of mitochondrial dyshomeostasis].

Sheng Li Xue Bao 2019 Apr;71(2):216-224

Department of Pharmacology, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.

Obesity is an important risk factor for cardiovascular diseases, which can lead to a variety of cardiovascular diseases including myocardial remodeling. Obesity may induce myocardial dysfunction by affecting hemodynamics, inducing autonomic imbalance, adipose tissue dysfunction, and mitochondrial dyshomeostasis. The key necessary biochemical functions for metabolic homeostasis are performed in mitochondria, and mitochondrial homeostasis is considered as one of the key determinants for cell viability. Read More

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Heart rate variability in type 2 diabetic subjects randomized to liraglutide or glimepiride treatment, both in combination with metformin: A randomized, open, parallel-group study.

Endocrinol Diabetes Metab 2019 Apr 6;2(2):e00058. Epub 2019 Feb 6.

Institution of Medical Sciences Örebro University Örebro Sweden.

Aims: Reduced heart rate variability (HRV) and increased heart rate (HR) are associated with cardiovascular (CV) mortality. In the Liraglutide Effect and Action in Diabetes outcome trial, it was demonstrated a lower rate of CV events in type 2 diabetes (T2D) patients treated with liraglutide compared to placebo. We aimed to investigate the effects of liraglutide compared with glimepiride treatment in T2D patients on the CV risk parameters HR and HRV. Read More

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http://dx.doi.org/10.1002/edm2.58DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458482PMC

Preoperative anxiety among adult patients undergoing elective surgery: a prospective survey at a general hospital in Ethiopia.

Patient Saf Surg 2019 8;13:18. Epub 2019 Apr 8.

Hawassa University, College of medicine and health sciences, School of Nursing, Hawassa, SNNPR Ethiopia.

Background: Major life changes are among factors that cause anxiety, and one of these changes is surgery. Hospitalization, regardless of disease, is known to provoke anxiety in the patient admitted for surgery. Anxiety is an unpleasant disturbing experience that involves way of thinking of tension, apprehension, uneasiness and high autonomic activity. Read More

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http://dx.doi.org/10.1186/s13037-019-0198-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454677PMC

CrossTalk proposal: Heart rate variability is a valid measure of cardiac autonomic responsiveness.

J Physiol 2019 Apr 21. Epub 2019 Apr 21.

Department of Cardiology and Pneumology, Heart Center - University of Göttingen Medical Center, Göttingen, Germany.

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https://onlinelibrary.wiley.com/doi/abs/10.1113/JP277500
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http://dx.doi.org/10.1113/JP277500DOI Listing
April 2019
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CrossTalk opposing view: Heart rate variability as a measure of cardiac autonomic responsiveness is fundamentally flawed.

J Physiol 2019 Apr 21. Epub 2019 Apr 21.

Division of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.

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http://dx.doi.org/10.1113/JP277501DOI Listing

Rebuttal from Mark Boyett, Yanwen Wang and Alicia D'Souza.

J Physiol 2019 Apr 21. Epub 2019 Apr 21.

Division of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.

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http://dx.doi.org/10.1113/JP277963DOI Listing

Rebuttal from Marek Malik, Katerina Hnatkova, Heikki V. Huikuri, Federico Lombardi, Georg Schmidt and Markus Zabel.

J Physiol 2019 Apr 21. Epub 2019 Apr 21.

Department of Cardiology and Pneumology, Heart Center - University of Göttingen Medical Center, Göttingen, Germany.

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http://dx.doi.org/10.1113/JP277962DOI Listing

[Emotional disorders in patients with controlled hypertension].

Zh Nevrol Psikhiatr Im S S Korsakova 2019 ;119(1. Vyp. 2):82-87

Evdokimov Moscow State University of Medicine and Dentistry of Ministry of Healthcare of Russian Federation, Moscow, Russia.

Aim: To conduct a comprehensive examination of patients with controlled hypertension, including assessment of the functional state of the cardiovascular system, vegetative and psycho-emotional status.

Material And Methods: The study involved 80 patients (51 men, 29 women) divided into 2 groups: 60 patients with essential hypertension (EH) without concomitant severe pathology and normal blood pressure during the preceding 3 months (group 1) and 20 healthy patients without EH (group 2). Anthropometric parameters (height, weight, body mass index), parameters of central hemodynamic (heart rate, systolic and diastolic blood pressure), vegetative status (vegetative Kerdo index), mental and emotional status (SCL-90R, Leonhard questionnaire, HADS, SF-36, MPQ) were assessed. Read More

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http://dx.doi.org/10.17116/jnevro20191191282DOI Listing
January 2019

[Peculiarities of affective disorders in residual cerebral insufficiency].

Zh Nevrol Psikhiatr Im S S Korsakova 2019 ;119(1. Vyp. 2):45-49

Sechenov First Moscow State Medical University, Moscow, Russia.

Aim: To determine clinical and psychopathological features of anxiety-depressive disorders in patients with cerebral residual organic insufficiency.

Material And Methods: One hundred and fourteen patients with anxiety-depressive disorders and cerebral residual-organic insufficiency were studied. Psychopathological, psychometric, statistical methods were used. Read More

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http://dx.doi.org/10.17116/jnevro20191191245DOI Listing
January 2019

Activation of ADAM17 (A Disintegrin and Metalloprotease 17) on Glutamatergic Neurons Selectively Promotes Sympathoexcitation.

Hypertension 2019 Apr 22:HYPERTENSIONAHA11912832. Epub 2019 Apr 22.

From the Department of Pharmacology and Experimental Therapeutics (J.X., S.M., E.L.), Louisiana State University Health Sciences Center, New Orleans.

Chronic activation of the brain renin-angiotensin system contributes to the development of hypertension by altering autonomic balance. Beyond the essential role of Ang II (angiotensin II) type 1 receptors, ADAM17 (A disintegrin and metalloprotease 17) is also found to promote brain renin-angiotensin system overactivation. ADAM17 is robustly expressed in various cell types within the central nervous system. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.119.12832DOI Listing

Adrenocortical and autonomic attunement between romantic partners in emerging adulthood.

Stress 2019 Apr 22:1-11. Epub 2019 Apr 22.

a Department of Human Development and Family Studies , Iowa State University , Ames , IA , USA.

Parent-child physiological attunement, particularly during stressful situations, appears adaptive as shared stress reactivity may promote dyadic engagement. Romantic partners eventually replace parents as the primary support figure, yet it remains unclear whether romantic partners buffer physiological stress or display physiological attunement as most studies on adults examine attunement during conflict paradigms. The present study examined physiological attunement in 63 emerging adult romantic partner dyads (one partner was the active participant, the other the observer) during the Trier Social Stress Task (TSST). Read More

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http://dx.doi.org/10.1080/10253890.2019.1600502DOI Listing

Hypoglycemic thalamic activation in type 1 diabetes is associated with preserved symptoms despite reduced epinephrine.

J Cereb Blood Flow Metab 2019 Apr 20:271678X19842680. Epub 2019 Apr 20.

1 Department of Diabetes, School of Life Course Sciences, King's College London, London, UK.

Brain responses to low plasma glucose may be key to understanding the behaviors that prevent severe hypoglycemia in type 1 diabetes. This study investigated the impact of long duration, hypoglycemia aware type 1 diabetes on cerebral blood flow responses to hypoglycemia. Three-dimensional pseudo-continuous arterial spin labeling magnetic resonance imaging was performed in 15 individuals with type 1 diabetes and 15 non-diabetic controls during a two-step hyperinsulinemic glucose clamp. Read More

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http://dx.doi.org/10.1177/0271678X19842680DOI Listing

Capturing fatigue parameters: The impact of vagal processing in multiple sclerosis related cognitive fatigue.

Mult Scler Relat Disord 2019 Apr 13;32:13-18. Epub 2019 Apr 13.

Institute of Psychology, Carl von Ossietzy University of Oldenburg, Department VI - Medicine and Health Sciences, Ammerländer Heerstr. 114-11826129, Oldenburg, Germany; Klinikum Bremen-Ost, Department of Neurology, Züricher Str. 40, 28325 Bremen, Germany. Electronic address:

Background: Causes of fatigue in Multiple Sclerosis remain elusive. Recently, we developed a model linking cognitive fatigue to inflammatory processes based on a neuroinflammatory reflex-arc instantiated by the vagus nerve. The relation between experienced autonomic dysfunctions, based on vagal processing, and cognitive fatigue is well-known, but an examination of the association of objectively measured vagal activity and cognitive fatigue is missing. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22110348193017
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http://dx.doi.org/10.1016/j.msard.2019.04.013DOI Listing
April 2019
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Robotic complete excision of sacrocolpopexy mesh. Standardized technique.

J Minim Invasive Gynecol 2019 Apr 18. Epub 2019 Apr 18.

From the Department of Gynecology. Mayo Clinic, Phoenix, Arizona.

Study Objective: Description of a standardized technique for robotic complete excision of sacrocolpopexy mesh.

Design: Step by Step video demonstration of the technique.

Setting: Tertiary care academic hospital PATIENTS: Three patients with persistent pain following sacrocolpopexy mesh insertion. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15534650193019
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http://dx.doi.org/10.1016/j.jmig.2019.04.016DOI Listing
April 2019
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Short communication: Heart rate variability, step, and rumination behavior of dairy cows milked in a rotary milking system.

J Dairy Sci 2019 Apr 17. Epub 2019 Apr 17.

MTA-SZIE Large Animal Clinical Research Group, Üllő, Dóra major H-2225, Hungary.

Step behavior, heart rate (HR), the high-frequency (HF) component of heart rate variability (HRV), the ratio of the low-frequency (LF) and HF components (LF/HF ratio) as well as rumination behavior during milking were investigated in dairy cows milked in a high-capacity rotary milking system (n = 49) to study animals' stress responses to the milking process. Cardiac parameters were analyzed for undisturbed standing (baseline) and for the stages of the morning, afternoon, and evening milking processes (i.e. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00220302193036
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http://dx.doi.org/10.3168/jds.2018-15842DOI Listing
April 2019
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Cardiac syncope recurrence in type 2 diabetes mellitus patients vs. normoglycemics patients: the CARVAS study.

Diabetes Res Clin Pract 2019 Apr 17. Epub 2019 Apr 17.

Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy. Electronic address:

Study hypothesis cardiac autonomic dysfunction might lead to higher vaso vagal syncope (VVS) recurrence rate in type 2 diabetes mellitus (T2DM) patients vs. non diabetics patients.

Background: VVS recurrence might be due to alterations of autonomic system function, as assessed by heart rate variability (HRV). Read More

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http://dx.doi.org/10.1016/j.diabres.2019.04.015DOI Listing

Onset of efficacy and duration of response of galcanezumab for the prevention of episodic migraine: a post-hoc analysis.

J Neurol Neurosurg Psychiatry 2019 Apr 19. Epub 2019 Apr 19.

Eli Lilly and Company, Indianapolis, Indiana, USA.

Background And Objective: As new migraine prevention treatments are developed, the onset of a preventive effect, how long it is maintained and whether patients initially non-responsive develop clinically meaningful responses with continued treatment can be assessed.

Methods: Analyses were conducted post-hoc of a double-blind, placebo-controlled, phase II-a study in patients with episodic migraine receiving galcanezumab 150 mg or placebo biweekly for 12 weeks ( 13:885, 2014). The number of migraine headache days per week, and onset of efficacy measured as the first week galacanezumab separated from placebo were determined. Read More

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http://jnnp.bmj.com/lookup/doi/10.1136/jnnp-2018-320242
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http://dx.doi.org/10.1136/jnnp-2018-320242DOI Listing
April 2019
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Pavlovian-to-instrumental transfer after human threat conditioning.

Learn Mem 2019 May 19;26(5):167-175. Epub 2019 Apr 19.

Computational Psychiatry Research, Department of Psychiatry, Psychotherapy, and Psychosomatics, Psychiatric Hospital, University of Zurich, 8032 Zurich, Switzerland.

Threat conditioning is a common associative learning model with translational relevance. How threat-conditioned cues impact on formally unrelated instrumental behavior in humans is not well known. Such an effect is known as Pavlovian-to-instrumental transfer (PIT). Read More

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http://learnmem.cshlp.org/lookup/doi/10.1101/lm.049338.119
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http://dx.doi.org/10.1101/lm.049338.119DOI Listing
May 2019
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Fatigue in Epstein-Barr virus infected adolescents and healthy controls: A prospective multifactorial association study.

J Psychosom Res 2019 Apr 10. Epub 2019 Apr 10.

Department of Pediatrics, Akershus University Hospital, Lørenskog N-1478, Norway.

Objective: Acute Epstein-Barr virus (EBV) infection is a known trigger of both acute and chronic fatigue. The aim of this study was to investigate associations to fatigue in adolescents with EBV infection during the initial stage and six months after, as well as in healthy controls.

Methods: 200 adolescents (12-20 years old) with EBV infection were assessed as soon as possible after the onset of symptoms (EBV) and six months later (EBV, 5 drop-outs). Read More

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http://dx.doi.org/10.1016/j.jpsychores.2019.04.008DOI Listing

[Visualisation and Radiofrequency Ablation of Sympathetic Innervation Loci in the Left Atrium in Patients with Paroxysmal Atrial Fibrillation].

Kardiologiia 2019 Apr 16;59(4):33-38. Epub 2019 Apr 16.

National Medical Research Center named after acad. E. N. Meshalkin, Novosibirsk.

Introduction: A novel cardiac gamma camera utilizes the radiopharmaceutical Iodine-123-Meta-iodobenzylguanidine (123I-MIBG) to visualize cardiac sympathetic innervation. Physiological accumulation of 123I-mIBG provides an anatomical quantitative determination of the structures of the autonomic nervous system (ANS) with discrete uptake areas (DUA) of sympathetic activity located in the left atrium (LA) corresponding to the main ganglionic plexi (GP) clusters that could not previously be visualized.

Aim: to visualize the DUA of the heart in patients with paroxysmal atrial fibrillation (AF) and to assess the effect of radiofrequency ablation (RFA) on DUA in LA. Read More

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http://dx.doi.org/10.18087/cardio.2019.4.10249DOI Listing
April 2019
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Distraction and reappraisal efficiency on immediate negative emotional responses: role of trait anxiety.

Anxiety Stress Coping 2019 Apr 19:1-16. Epub 2019 Apr 19.

a Institute of Psychology , University of Lausanne , Lausanne , Switzerland.

Background And Objectives: Emotion regulation involves attempts to influence emotion unfolding and may target experiential, expressive and physiological responses. Several strategies can be used, such as reappraisal (re-evaluating the emotional situation to reduce its emotional meaning) or distraction (turning the attention toward non-emotional aspects of the situation). Previous research on these regulation strategies produced contrasting results regarding their efficiency and we hypothesize that this could be due to individual differences such as trait anxiety. Read More

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http://dx.doi.org/10.1080/10615806.2019.1597859DOI Listing

Characterization of the Asymmetry of the Cardiac and Sympathetic Arms of the Baroreflex From Spontaneous Variability During Incremental Head-Up Tilt.

Front Physiol 2019 2;10:342. Epub 2019 Apr 2.

Department of Cardiothoracic, Vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, Milan, Italy.

Hysteresis of the baroreflex (BR) is the result of the different BR sensitivity (BRS) when arterial pressure (AP) rises or falls. This phenomenon has been poorly studied and almost exclusively examined by applying pharmacological challenges and static approaches disregarding causal relations. This study inspects the asymmetry of the cardiac BR (cBR) and vascular sympathetic BR (sBR) in physiological closed loop conditions from spontaneous fluctuations of physiological variables, namely heart period (HP) and systolic AP (SAP) leading to the estimation of cardiac BRS (cBRS) and muscle sympathetic nerve activity (MSNA) and diastolic AP (DAP) leading to the estimation of vascular sympathetic BRS (sBRS). Read More

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http://dx.doi.org/10.3389/fphys.2019.00342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454064PMC

Proconvertase Furin Is Downregulated in Postural Orthostatic Tachycardia Syndrome.

Front Neurosci 2019 29;13:301. Epub 2019 Mar 29.

Department of Clinical Sciences, Faculty of Medicine, Clinical Research Center, Lund University, Malmö, Sweden.

Postural Orthostatic Tachycardia Syndrome (POTS) is a cardiovascular autonomic disorder characterized by orthostatic intolerance and high prevalence among young women. The etiology of POTS is uncertain, though autoimmunity and inflammation may play an important role. We aimed to identify novel inflammatory biomarkers associated with POTS. Read More

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https://www.frontiersin.org/article/10.3389/fnins.2019.00301
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http://dx.doi.org/10.3389/fnins.2019.00301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455076PMC
March 2019
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Changes in MIDAS, Perceived Stress, Frontalis Muscle Activity and Non-Steroidal Anti-Inflammatory Drugs Usage in Patients with Migraine Headache without Aura following Ayurveda and Yoga Compared to Controls: An Open Labeled Non-Randomized Study.

Ann Neurosci 2018 Dec 11;25(4):250-260. Epub 2018 Sep 11.

Division of Yoga and Life Sciences, Swami Vivekananda Yoga Anusandhana Samsthana (S-VYASA) A Deemed to be University, Bengaluru, India.

Background: There has been a significant increase in the use of complementary and integrative medicine to provide long-term healing solutions in migraine headache patients. Knowing the limitations of conventional medical approach, the present study evaluated the influence of two Indian traditional systems of medicine on migraine-related disability, autonomic variables, perceived stress, and muscle activity in patients with migraine headache without aura.

Methods: Thirty subjects recruited to the Ayurveda and Yoga (AY) group underwent traditional (Bio-purification) using therapeutic Purgation followed by yoga therapy, while 30 subjects of control (CT) group continued on symptomatic treatment (non-steroidal anti-inflammatory drugs [NSAID's]) for 90 days. Read More

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http://dx.doi.org/10.1159/000492269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470355PMC
December 2018
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The expression of androgen receptor in neurons of the anterior pelvic ganglion and celiac-superior mesenteric ganglion in the male pig.

Pol J Vet Sci 2019 Mar;22(1):151-155

Department of Animal Anatomy, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 13, 10-718 Olsztyn, Poland.

The present study investigated the expression of androgen receptor (AR) in neurons of the anterior pelvic ganglion (APG) and celiac-superior mesenteric ganglion (CSMG; ganglion not involved in the innervation of reproductive organs) in the male pig with quantitative real-time PCR (qPCR) and immunohistochemistry. qPCR investigations revealed that the level of AR gene expression in the APG tissue was approximately 2.5 times higher in the adult (180-day-old) than in the juvenile (7-day-old) boars. Read More

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http://dx.doi.org/10.24425/pjvs.2019.127081DOI Listing

Tonic pupils: an unusual autonomic involvement in chronic inflammatory demyelinating polyneuropathy (CIDP).

Neurol Sci 2019 Apr 17. Epub 2019 Apr 17.

Department of Neurology, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Pedro de Toledo, 650, São Paulo, SP, 04039-002, Brazil.

Background: Chronic inflammatory demyelinating polyneuropathy (CIDP) is a neuropathy which affects mainly large myelinated axons and has a typically mild autonomic dysfunction mainly from postganglionic nerve fiber involvement.

Case Report: We report here an acute onset CIDP initially diagnosed as Guillain-Barré syndrome (GBS), unresponsive to treatment with intravenous immunoglobulin (IVIg), which later responded to plasmapheresis and corticoids. The patient had a markedly distal demyelination, prominent cranial nerve involvement and, interestingly, bilateral fixed dilated pupils. Read More

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http://dx.doi.org/10.1007/s10072-019-03890-8DOI Listing
April 2019
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Exploring hyperhidrosis and related thermoregulatory symptoms as a possible clinical identifier for the dysautonomic subtype of Parkinson's disease.

J Neurol 2019 Apr 17. Epub 2019 Apr 17.

King's College London, Institute of Psychiatry, Psychology and Neuroscience, Department of Basic and Clinical Neurosciences, De Crespigny Park, London, SE5 8AF, UK.

Objective: To identify associated (non-)motor profiles of Parkinson's disease (PD) patients with hyperhidrosis as a dominant problem.

Methods: This is a cross-sectional, exploratory, analysis of participants enrolled in the Non-motor Longitudinal International Study (NILS; UKCRN No: 10084) at the Parkinson's Centre at King's College Hospital (London, UK). Hyperhidrosis scores (yes/no) on question 28 of the Non-Motor Symptom Questionnaire were used to classify patients with normal sweat function (n = 172) and excessive sweating (n = 56) (Analysis 1; n = 228). Read More

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http://dx.doi.org/10.1007/s00415-019-09325-wDOI Listing
April 2019
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Pacing therapy in the management of unexplained syncope: a tertiary care centre prospective study.

Open Heart 2019 25;6(1):e001015. Epub 2019 Mar 25.

Department of Clinical Sciences, Lund University, Malmö, Sweden.

Objective: Pacemaker (PM) therapy is effective when syncope is associated with bradycardia, but syncope recurrences and fall injuries after PM implantation may occur. We aimed to survey indications and outcomes of PM implantation, following evaluation of unexplained syncope.

Methods: Among 1666 consecutive unpaced patients investigated in a tertiary syncope unit by carotid-sinus massage (CSM), head-up tilt test (HUT) and ECG monitoring, 106 (6. Read More

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http://openheart.bmj.com/lookup/doi/10.1136/openhrt-2019-001
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http://dx.doi.org/10.1136/openhrt-2019-001015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443123PMC
March 2019
2 Reads

Scorpion venom increases acetylcholine release by prolonging the duration of somatic nerve action potentials.

Neuropharmacology 2019 Apr 14. Epub 2019 Apr 14.

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Robertson Trust Wing Building, Room 601, 161 Cathedral Street, G4 0RE, Glasgow, UK. Electronic address:

Scorpionism is frequently accompanied by a massive release of catecholamines and acetylcholine from peripheral nerves caused by neurotoxic peptides present in these venoms, which have high specificity and affinity for ion channels. Tityus bahiensis (T. bahiensis) is the second most medically important scorpion species in Brazil but, despite this, its venom remains scarcely studied, especially with regard to its pharmacology on peripheral (somatic and autonomic) nervous system. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2019.04.013DOI Listing
April 2019
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Enhancement of excitatory transmission in NTS neurons projecting to ventral medulla of rats exposed to sustained hypoxia is blunted by minocycline.

J Physiol 2019 Apr 17. Epub 2019 Apr 17.

Department of Physiology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, 14049-900, SP, Brazil.

Key Points: -Rats submitted to sustained hypoxia (SH) presents increase in arterial pressure (AP) as well as increase in glutamatergic transmission in the nucleus tractus solitarius (NTS) neurons sending projections to ventrolateral medulla (VLM). -Treatment with minocycline, a microglial inhibitor, attenuated the increase in AP in response to SH. -The increase in the amplitude of glutamatergic post-synaptic currents in the NTS-VLM neurons, induced by post-synaptic mechanisms, was blunted by minocycline treatment. Read More

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http://dx.doi.org/10.1113/JP277532DOI Listing
April 2019
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Authors' response to the letter: Takotsubo syndrome: a neurocardiac syndrome inside the autonomic nervous system.

Heart Fail Rev 2019 Apr 16. Epub 2019 Apr 16.

Department of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, 1b Banacha Street, 02-097, Warsaw, Poland.

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http://dx.doi.org/10.1007/s10741-019-09789-yDOI Listing

Dysautonomia and hyponatraemia as harbingers of Guillain-Barre syndrome.

BMJ Case Rep 2019 Apr 15;12(4). Epub 2019 Apr 15.

Department of Critical Care, Jaslok Hospital and Research Centre, Mumbai, Maharashtra, India.

A 56-year-old woman with a medical history of hypertension presented to our hospital with back pain, abdominal pain, vomiting and elevated blood pressure. The laboratory parameters including evaluation for secondary hypertension were within normal ranges at the time of presentation. During her hospitalisation, fluctuations in her blood pressure and pulse were observed which were attributed to autonomic disturbances, the cause of which was unknown. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22692
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http://dx.doi.org/10.1136/bcr-2018-226925DOI Listing
April 2019
3 Reads

Increased QT and P-wave dispersion during attack-free period in pediatric patients with migraine attacks.

Cardiol Young 2019 Apr 17:1-4. Epub 2019 Apr 17.

Department of Pediatric Neurology,Medeniyet University Faculty of Medicine,Istanbul,Turkey.

Introduction: Migraine is a common neurovascular disease characterised with recurrent attacks by pain-free periods. It has been suggested that both sympathetic and parasympathetic dysfunctions play a role in its pathophysiology.

Aim: The aim of our study was to investigate the ECG changes during attack-free period in children with migraine, in terms of QTc interval, QTc, and P-wave dispersion to evaluate the autonomic nervous system disturbance. Read More

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http://dx.doi.org/10.1017/S1047951119000088DOI Listing

Clinical characteristics of autoimmune GFAP astrocytopathy.

J Neuroimmunol 2019 Apr 9;332:91-98. Epub 2019 Apr 9.

Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Gifu, Japan.

The clinical features of autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy remain to be elucidated. We describe here the clinical features of 14 patients with GFAP astrocytopathy confirmed by detection of GFAP-IgG in cerebrospinal fluid (CSF). The novel findings of this study are as follows. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.04.004DOI Listing
April 2019
1 Read

The impact of informal cancer caregiving: A literature review on psychophysiological studies.

Eur J Cancer Care (Engl) 2019 Apr 16:e13042. Epub 2019 Apr 16.

Departamento de Psicologia, Centro de Investigação em Psicologia (CIP-UAL), Universidade Autónoma de Lisboa Luís de Camões, Lisboa, Portugal.

Caregiving can be experienced as a stressful process, which can cause psychological and physical consequences. The combination of prolonged stress and the physical demands of caregiving may impair the physiological functioning of caregivers and increase the risk of health problems creating considerable stress in the life of caregivers regarding emotional, physical, social and financial areas. This literature review explored studies that used measures of the autonomic nervous system in caregivers of oncology patients such as electrodermal and cardiovascular (re)activity. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ecc.13042
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http://dx.doi.org/10.1111/ecc.13042DOI Listing
April 2019
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Role of autonomic dysfunction in the regulation of myocardial blood flow in systemic sclerosis evaluated by cardiac magnetic resonance.

Int J Rheum Dis 2019 Apr 15. Epub 2019 Apr 15.

Department of Clinical Medicine, Clinical Immunology Unit-Scleroderma Center, Sapienza University of Rome, Rome, Italy.

Aim: Autonomic dysfunction (AD) is an early feature of systemic sclerosis (SSc). A regular endothelial function is a prerequisite for normal response of the myocardial blood flow (MBF) to cold pressure test (CPT). The aim of the study was to evaluate the relation between MBF and AD at rest and after CPT in asymptomatic SSc patients. Read More

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http://dx.doi.org/10.1111/1756-185X.13569DOI Listing
April 2019
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Selective Sensory Axon Reinnervation and TRPV1 Activation.

Mol Neurobiol 2019 Apr 15. Epub 2019 Apr 15.

Division of Neurology, Department of Medicine and the Neuroscience and Mental Health Institute, University of Alberta, 132A-Clinical Sciences Building, 11350 Ave, Edmonton, Alberta, T6G 2G3, Canada.

Current strategies to enhance regeneration of peripheral neurons involve broad activation of sensory, autonomic, and motor axons. Peripheral neuron regeneration is limited in persons with damage or disease of peripheral axons. Here, we provide evidence that subtoxic activation of TRPV1 channels in sensory neurons is associated with activation of growth and subtle changes in skin reinnervation. Read More

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http://link.springer.com/10.1007/s12035-019-1574-6
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http://dx.doi.org/10.1007/s12035-019-1574-6DOI Listing
April 2019
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Time-Resolved Directional Brain-Heart Interplay Measurement Through Synthetic Data Generation Models.

Ann Biomed Eng 2019 Apr 15. Epub 2019 Apr 15.

Bioengineering and Robotics Research Center E.Piaggio & Department of Information Engineering, School of Engineering, University of Pisa, Largo Lucio Lazzarino 1, 56122, Pisa, Italy.

Although a plethora of synthetic data generation models have been proposed to validate biomarkers of brain and cardiovascular dynamics separately, a limited number of computational methods estimating directed brain-heart information flow are currently available in the scientific literature. This study introduces a computational framework exploiting existing generative models for a novel time-resolved quantification of causal brain-heart interplay. Exemplarily, having electroencephalographic signals and heart rate variability series as inputs, respective synthetic data models are coupled through parametrised functions defined in accordance with current central autonomic network (CAN) knowledge. Read More

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http://dx.doi.org/10.1007/s10439-019-02251-yDOI Listing

Haemodynamic changes during prone positioning in anaesthetised chronic cervical myelopathy patients.

Indian J Anaesth 2019 Mar;63(3):212-217

Department of Neuroanesthesia and Neurocritical Care, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

Background And Aims: Anaesthetised patients, when positioned prone, experience hypotension and reduction in cardiac output. Associated autonomic dysfunction in cervical myelopathy patients predisposes them to haemodynamic changes. The combined effect of prone positioning and autonomic dysfunction in anaesthetised patients remains unknown. Read More

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http://dx.doi.org/10.4103/ija.IJA_810_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423938PMC

Low plasma adropin concentrations increase risks of weight gain and metabolic dysregulation in response to a high-sugar diet in male nonhuman primates.

J Biol Chem 2019 Apr 15. Epub 2019 Apr 15.

University of California Davis.

Mouse studies linking adropin, a peptide hormone encoded by the energy homeostasis associated () gene, to biological clocks and to glucose and lipid metabolism suggest a potential therapeutic target for managing diseases of metabolism. However, adropin's roles in human metabolism are unclear. expression profiling in a nonhuman primate diurnal transcriptome atlas (GSE98965) revealed a dynamic and diurnal pattern of expression. Read More

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http://dx.doi.org/10.1074/jbc.RA119.007528DOI Listing

Measles, magic and misidentifications: a defence of the two-factor theory of delusions.

Authors:
Ryan McKay

Cogn Neuropsychiatry 2019 Apr 16:1-8. Epub 2019 Apr 16.

a Department of Psychology , Royal Holloway, University of London , Egham , UK.

Corlett (Corlett, P. (this issue). Factor one, familiarity and frontal cortex: A challenge to the two-factor theory of delusions. Read More

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http://dx.doi.org/10.1080/13546805.2019.1607273DOI Listing

Hyperglycaemia-Induced Downregulation in Expression of nNOS Intramural Neurons of the Small Intestine in the Pig.

Int J Mol Sci 2019 Apr 4;20(7). Epub 2019 Apr 4.

Department of Clinical Physiology Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego Str. 13, 10-719 Olsztyn, Poland.

Diabetic autonomic peripheral neuropathy (PN) involves a broad spectrum of organs. One of them is the gastrointestinal (GI) tract. The molecular mechanisms underlying the pathogenesis of digestive complications are not yet fully understood. Read More

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http://dx.doi.org/10.3390/ijms20071681DOI Listing
April 2019
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High Cervical Spinal Cord Stimulation: A One Year Follow-Up Study on Motor and Non-Motor Functions in Parkinson's Disease.

Brain Sci 2019 Apr 3;9(4). Epub 2019 Apr 3.

Department of Biotechnological and Applied Clinical Sciences (DISCAB), University of L'Aquila, 67100 L'Aquila, Italy.

Background: The present study investigated the effectiveness of stimulation applied at cervical levels on pain and Parkinson's disease (PD) symptoms using either tonic or burst stimulation mode.

Methods: Tonic high cervical spinal cord stimulation (T-HCSCS) was applied on six PD patients suffering from low back pain and failed back surgery syndrome, while burst HCSCS (B-HCSCS) was applied in twelve PD patients to treat primarily motor deficits. Stimulation was applied percutaneously with quadripolar or octapolar electrodes. Read More

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http://dx.doi.org/10.3390/brainsci9040078DOI Listing
April 2019
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Influence of Sex, Menstrual Cycle, and Menopause Status on the Exercise Pressor Reflex.

Med Sci Sports Exerc 2019 May;51(5):874-881

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.

In this review, we highlight the underlying mechanisms responsible for the sex differences in the exercise pressor reflex (EPR), and, importantly, the impact of sex hormones and menopausal status. The EPR is attenuated in premenopausal women compared with age-matched men. Specifically, activation of the metaboreflex (a component of the EPR) results in attenuated increases in blood pressure and sympathetic vasomotor outflow compared with age-matched men. Read More

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http://dx.doi.org/10.1249/MSS.0000000000001877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467496PMC
May 2019
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Cervical ganglioneuroma: A case report and review of the literature.

Medicine (Baltimore) 2019 Apr;98(15):e15203

Department of Otolaryngology-Head and Neck Surgery, First Hospital of Jilin University, Jilin University, Changchun 130021, Jilin Province, China.

Rationale: Ganglioneuromas are benign neoplasm of neuroblastic origin which arise from central or peripheral parts of the autonomic nervous system. They are normally found at posterior mediastinum, retroperitoneum, and the adrenal gland but ganglioneuromas are rarely found in the cervical region.

Patient Concerns: A 12-year-old boy was admitted with a left-lateral neck mass slow growing over a 7-days duration. Read More

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http://dx.doi.org/10.1097/MD.0000000000015203DOI Listing
April 2019
2 Reads