191,235 results match your criteria Autonomic & autacoid pharmacology[Journal]


Two-Stage Turnbull-Cutait Pull-Through Coloanal Anastomosis for Low Rectal Cancer: A Randomized Clinical Trial.

JAMA Surg 2020 Jun 3:e201625. Epub 2020 Jun 3.

Colorectal Unit, IDIBELL, Bellvitge University Hospital, Department of General and Digestive Surgery, University of Barcelona, Barcelona, Spain.

Importance: Two-stage Turnbull-Cutait pull-through hand-sewn coloanal anastomosis seems to provide benefits in terms of postoperative morbidity compared with standard hand-sewn coloanal anastomosis associated with diverting ileostomy and further ileostomy reversal in patients operated on for low rectal cancer.

Objective: To compare 30-day postoperative and 1-year follow-up results of Turnbull-Cutait pull-through hand-sewn coloanal anastomosis and standard hand-sewn coloanal anastomosis after ultralow rectal resection for rectal cancer.

Design, Setting, And Participants: Multicenter randomized clinical trial. Read More

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http://dx.doi.org/10.1001/jamasurg.2020.1625DOI Listing

The effect of early burn injury on sensitivity to future painful stimuli in dairy heifers.

PLoS One 2020 3;15(6):e0233711. Epub 2020 Jun 3.

Center for Animal Welfare, Department of Animal Science, University of California, Davis, California, United States of America.

Animals that experience painful procedures as neonates are more sensitive to pain later in life. We evaluated whether disbudding with a heated iron at 3 (n = 12), 35 (n = 9), or 56 (n = 20) d of age affected heifers' pain responses to vaccine injections at 11 mo of age. Heifers responded to the injection procedure with struggling and changes in eye temperature and heart rate variability compared to a sham procedure the day before, and still had a heightened response 6 d later, regardless of disbudding age. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233711PLOS

Flickering of cardiac state before the onset and termination of atrial fibrillation.

Chaos 2020 May;30(5):053137

National Heart Institute, 50400 Kuala Lumpur, Malaysia.

Complex dynamical systems can shift abruptly from a stable state to an alternative stable state at a tipping point. Before the critical transition, the system either slows down in its recovery rate or flickers between the basins of attraction of the alternative stable states. Whether the heart critically slows down or flickers before it transitions into and out of paroxysmal atrial fibrillation (PAF) is still an open question. Read More

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http://dx.doi.org/10.1063/1.5130524DOI Listing

Absence of Nocturnal Fall in Blood Pressure Detected by Ambulatory Blood Pressure Monitoring in Acute Chagas Disease Patients with Oral Infection.

Arq Bras Cardiol 2020 Apr 29;114(4):711-715. Epub 2020 May 29.

Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil.

Background The involvement of the autonomic nervous system is one of the mechanisms proposed to explain the progression of myocardial lesion in Chagas disease. Evidences have shown changes in sympathetic and parasympathetic nervous system since the acute phase of the disease, and studies to clarify the pathophysiological and prognostic value of these changes are needed. Objetives To assess blood pressure profile by ambulatory blood pressure monitoring (ABPM) in normotensive patients with acute Chagas disease (ACD) without apparent cardiac damage, and the influence of the infection on nocturnal blood pressure fall. Read More

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http://dx.doi.org/10.36660/abc.20190143DOI Listing

Nocturnal Blood Pressure Dipping and the Autonomic Nervous System.

Arq Bras Cardiol 2020 Apr 29;114(4):716-717. Epub 2020 May 29.

Departamento de Clínica, Faculdade de Ciências Médicas e da Saúde, PUC-SP, Sorocaba, SP, Brasil.

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http://dx.doi.org/10.36660/abc.20200280DOI Listing

Prevalence and Correlates of Cardiovascular Autonomic Neuropathy Among Patients with Diabetes in Uganda: A Hospital-Based Cross-sectional Study.

Glob Heart 2020 Mar 2;15(1):21. Epub 2020 Mar 2.

Department of Internal Medicine, Mbarara University of Science and Technology, Mbarara, UG.

Background: Cardiovascular autonomic neuropathy (CAN) is a common complication in individuals with diabetes mellitus (DM) but often overlooked in clinical practice. The burden and correlates of CAN have not been extensively studied in low-income countries, particularly in sub-Saharan Africa.

Objectives: To determine the prevalence and correlates of CAN among adults in ambulatory diabetes care in southwestern Uganda. Read More

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http://dx.doi.org/10.5334/gh.765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218768PMC

Ivabradine in Postural Orthostatic Tachycardia Syndrome: A Review of the Literature.

Cureus 2020 Apr 28;12(4):e7868. Epub 2020 Apr 28.

Cardiology, Kansas City University of Medicine and Biosciences, Joplin, USA.

Postural orthostatic tachycardia syndrome (POTS) is an autonomic disorder characterized by symptoms such as palpitations, dyspnea, chest discomfort, and lightheadedness affecting various systems. The pathophysiology of POTS is not completely understood due to a variety of symptoms showing that the disease is multifactorial. There is no approved uniform management strategy for POTS and hence, no drug has been approved by the United States (US) Food and Drug Administration (FDA) for it. Read More

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http://dx.doi.org/10.7759/cureus.7868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255540PMC

Parkinson Disease and Orthostatic Hypotension in the Elderly: Recognition and Management of Risk Factors for Falls.

Aging Dis 2020 May 9;11(3):679-691. Epub 2020 May 9.

3University of South Florida Parkinson's Disease and Movement Disorders Center, Parkinson Foundation Center of Excellence, Tampa, FL 33613, USA.

Parkinson disease (PD) is often associated with postural instability and gait dysfunction that can increase the risk for falls and associated consequences, including injuries, increased burden on healthcare resources, and reduced quality of life. Patients with PD have nearly twice the risk for falls and associated bone fractures compared with their general population counterparts of similar age. Although the cause of falls in patients with PD may be multifactorial, an often under-recognized factor is neurogenic orthostatic hypotension (nOH). Read More

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http://dx.doi.org/10.14336/AD.2019.0805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220277PMC

Hypoglycaemia and cardiac arrhythmias in diabetes.

Ther Adv Endocrinol Metab 2020 19;11:2042018820911803. Epub 2020 May 19.

Steno Diabetes Centre Copenhagen, Gentofte Hospital, Kildegårdsvej 28, Hellerup, 2900, Denmark.

Hypoglycaemia remains an inevitable risk in insulin-treated type 1 diabetes and type 2 diabetes and has been associated with multiple adverse outcomes. Whether hypoglycaemia is a cause of fatal cardiac arrhythmias in diabetes, or merely a marker of vulnerability, is still unknown. Since a pivotal report in 1991, hypoglycaemia has been suspected to induce cardiac arrhythmias in patients with type 1 diabetes, the so-called 'dead-in-bed syndrome'. Read More

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http://dx.doi.org/10.1177/2042018820911803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238305PMC

Heart rate variability: Measurement and emerging use in critical care medicine.

J Intensive Care Soc 2020 May 11;21(2):148-157. Epub 2019 Jun 11.

University of Liverpool and The Royal Liverpool University Hospital, Liverpool Healthcare Partners, Liverpool, UK.

Variation in the time interval between consecutive R wave peaks of the QRS complex has long been recognised. Measurement of this RR interval is used to derive heart rate variability. Heart rate variability is thought to reflect modulation of automaticity of the sinus node by the sympathetic and parasympathetic components of the autonomic nervous system. Read More

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http://dx.doi.org/10.1177/1751143719853744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238479PMC

Heart failure patients have enhanced cerebral autoregulation response in acute ischemic stroke.

J Thromb Thrombolysis 2020 Jun 1. Epub 2020 Jun 1.

Cardiovascular Research and Development Center, Faculty of Medicine, University of Porto, Alameda Professor Hernani Monteiro, 4200-319, Porto, Portugal.

The cerebrovascular effects of a failing heart-pump are largely unknown. Chronic heart failure (HF) might cause pre-conditioning effect on cerebral hemodynamics but not study so far in acute stroke. We aimed to investigate if HF induces effects in dynamic cerebral autoregulation (CA), within 6 h of symptom-onset through chronic stage of ischemic stroke. Read More

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http://dx.doi.org/10.1007/s11239-020-02166-9DOI Listing

Improvements in Heart Rate Variability in Women with Obesity: Short-term Effects of Sleeve Gastrectomy.

Obes Surg 2020 Jun 2. Epub 2020 Jun 2.

Physical Therapy Department, Universidad de Chile, Independencia 1027, 8380453, Santiago, Chile.

Purpose: Obesity has been associated with reduced vagal function and increased sympathetic activity. Cardiac autonomic dysfunction has emerged as a major risk factor in the development of cardiovascular disease. Cardiac autonomic function (CAF) can be assessed by heart rate variability (HRV), an independent predictor of mortality based on changes in time intervals between adjacent heartbeats (RR). Read More

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http://dx.doi.org/10.1007/s11695-020-04721-yDOI Listing

Influence of disease severity and cardiac autonomic tone on ventricular repolarization and dispersion in electrocardiographic assessment of patients with systemic lupus erythematosus.

Lupus 2020 Jun 2:961203320928402. Epub 2020 Jun 2.

Department of Internal Medicine and Cardiology, Medical University of Warsaw, Warsaw, Poland.

Background: There are no data on the influence of disease severity and cardiac autonomic tone on ventricular repolarization and dispersion in 24-hour Holter monitoring in systemic lupus erythematosus (SLE).

Methods: Consecutive 92 SLE and 51 healthy subjects were studied. The standard 12-lead electrocardiography (ECG), Holter monitoring with heart rate turbulence (HRT) and QT, Tp-e and Tp-e/QT ratio assessment (including corrected values) were performed. Read More

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http://dx.doi.org/10.1177/0961203320928402DOI Listing

Rats Lacking Dopamine Transporter Display Increased Vulnerability and Aberrant Autonomic Response to Acute Stress.

Biomolecules 2020 May 31;10(6). Epub 2020 May 31.

Department of Neurology and Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

The activity of the hypothalamus-pituitary-adrenal (HPA) axis is pivotal in homeostasis and presides the adaptative response to stress. Dopamine Transporter (DAT) plays a key role in the regulation of the HPA axis. We used young adult female DAT Knockout (KO) rats to assess the effects of DAT ablation (partial, heterozygous DAT+/-, or total, homozygous DAT-/-) on vulnerability to stress. Read More

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http://dx.doi.org/10.3390/biom10060842DOI Listing

Analysis of Well-Being and Anxiety among University Students.

Int J Environ Res Public Health 2020 May 30;17(11). Epub 2020 May 30.

Graduate Program in Business Administration-PPGA, Federal University of Santa Maria-UFSM, Av. Roraima n° 1000, Cidade Universitária, Camobi, Santa Maria, Rio Grande do Sul estado 97105-900, Brazil.

This article aims to interrelate dimensions of the well-being validation instruments proposed by Watson, Clark and Tellegen (PANAS) with generalized anxiety dimensions proposed by Spitzer et al. (GAD-7) and state-trait anxiety inventories proposed by Biaggio and Natalício (IDATE), using partial least squares structural equation modeling (PLS-SEM), in the case of individual university students in southern Brazil and the city of Buenos Aires, Argentina. We conducted a behavioral study, characterized as exploratory-descriptive, by applying a questionnaire survey to collect data though face-to face interviews to a group of 460 university students from June to August 2019. Read More

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http://dx.doi.org/10.3390/ijerph17113874DOI Listing

Tentonin 3 as a baroreceptor mechanosensor: not a stretch.

J Clin Invest 2020 Jun 2. Epub 2020 Jun 2.

Mechanical stretch of baroreceptors in the wall of the aortic arch and carotid sinus initiates autonomic reflexes to change heart rate and blood pressure for cardiovascular homeostasis. In this issue of the JCI, Lu et al. show that tentonin 3 (TTN3), a recently identified stretch-sensitive ion channel, was present at the vagus afferent nerve endings innervating the aortic arch to function as a baroreceptor. Read More

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http://dx.doi.org/10.1172/JCI138120DOI Listing

Dopaminergic symptoms in migraine: A cross-sectional study on 1148 consecutive headache center-based patients.

Cephalalgia 2020 Jun 2:333102420929023. Epub 2020 Jun 2.

Department of Human Sciences and Quality of Life Promotion, San Raffaele Roma Open University, Rome, Italy.

Background: Dopaminergic symptoms may be extremely pronounced in some migraine patients during the attack, representing a major source of disability.

Objectives: We aimed to carefully characterize the clinical picture of migraine patients with dopaminergic symptoms in a large patients' population as a putative migraine endophenotype, allowing more precise disease management, treatment and outcome prediction.

Methods: We screened 1148 consecutive tertiary care episodic and chronic migraine patients with face-to-face interviews collecting thorough data on lifestyle, socio-demographic factors, and clinical migraine features. Read More

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http://dx.doi.org/10.1177/0333102420929023DOI Listing

Gastrointestinal motility evaluation in children with orthostatic intolerance: Mayo Clinic experience.

Neurogastroenterol Motil 2020 Jun 1:e13863. Epub 2020 Jun 1.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.

Objective: Orthostatic intolerance (OI) and autonomic dysfunction (AD) are common in adolescents and young adults. Patients experience multisystem symptoms including gastrointestinal (GI), postural orthostatic tachycardia syndrome (POTS), orthostatic hypotension (OH), or only symptoms of OI (SOI) without significant findings on 70-degree head-up tilt testing (HUT). We hypothesize that patients with POTS, OH, and SOI show differences in GI symptoms and motility test and that heart rate (HR) changes on HUT predict severity of GI dysmotility. Read More

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http://dx.doi.org/10.1111/nmo.13863DOI Listing

Neuromuscular blockade management in the critically Ill patient.

J Intensive Care 2020 24;8:37. Epub 2020 May 24.

3Department of Anesthesiology, University of Minnesota Medical School, Minneapolis, MN USA.

Neuromuscular blocking agents (NMBAs) can be an effective modality to address challenges that arise daily in the intensive care unit (ICU). These medications are often used to optimize mechanical ventilation, facilitate endotracheal intubation, stop overt shivering during therapeutic hypothermia following cardiac arrest, and may have a role in the management of life-threatening conditions such as elevated intracranial pressure and status asthmaticus (when deep sedation fails or is not tolerated). However, current NMBA use has decreased during the last decade due to concerns of potential adverse effects such as venous thrombosis, patient awareness during paralysis, development of critical illness myopathy, autonomic interactions, and even residual paralysis following cessation of NMBA use. Read More

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http://dx.doi.org/10.1186/s40560-020-00455-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245849PMC

Perceptions, experiences, and understandings of cluster headache among GPs and neurologists: a qualitative study.

Br J Gen Pract 2020 Jun 1. Epub 2020 Jun 1.

School of Medicine, Keele University, Keele, UK.

Background: Cluster headache is a severe primary headache with a similar prevalence to that of multiple sclerosis. Cluster headache is characterised by unilateral trigeminal distribution of pain, ipsilateral cranial autonomic features, and a tendency to circadian and circannual periodicity.

Aim: To explore the perceptions, experiences, and understandings of cluster headache among GPs and neurologists. Read More

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http://dx.doi.org/10.3399/bjgp20X710417DOI Listing

Diverse dystonin gene mutations cause distinct patterns of isoform deficiency and phenotypic heterogeneity in mice.

Dis Model Mech 2020 May 21;13(5). Epub 2020 May 21.

Division of Neurobiology and Anatomy, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8510, Japan

Loss-of-function mutations in dystonin () can cause hereditary sensory and autonomic neuropathy type 6 (HSAN-VI) or epidermolysis bullosa simplex (EBS). Recently, -related diseases were recognized to be more complex than previously thought because a patient exhibited both neurological and skin manifestations, whereas others display only one or the other. A single locus produces at least three major isoforms: (neuronal isoform), (muscular isoform) and (epithelial isoform). Read More

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http://dx.doi.org/10.1242/dmm.041608DOI Listing

Therapies for diabetic gastroparesis: A protocol for a systematic review and network meta-analysis.

Medicine (Baltimore) 2020 May;99(21):e20461

Department of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine.

Background: Diabetic gastroparesis (DG) is a common autonomic neuropathy which impacts on nutritional state and quality of life in diabetic patients, and it also adversely affects glycemic control in diabetes. The prevalence of DG is growing with the number of patients with diabetes continues to increase. However, there is no definitive answer as to which of the current therapies is the best for the clinical treatment of the different manifestations of DG. Read More

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http://dx.doi.org/10.1097/MD.0000000000020461DOI Listing

Treatment of Neurocardiogenic Syncope: From Conservative to Cutting-edge.

J Innov Card Rhythm Manag 2018 Jul 15;9(7):3221-3231. Epub 2018 Jul 15.

Center for Arrhythmia Care, Section of Cardiology, the University of Chicago Medicine, Chicago, IL, USA.

Neurocardiogenic syncope is the most frequent cause of syncope in the general population. Many years have been spent on determining an effective treatment for this condition. Conventional treatment usually follows a tiered approach for neurocardiogenic syncope, as follows: first, lifestyle modification, including increased fluid intake and the introduction of physical counterpressure maneuvers, is tried; then the use of targeted pharmacologic therapy, particularly agents that support blood pressure or that drive blood pressure is attempted; and, finally, pacemaker implantation in patients with a predominant cardioinhibitory component to their syncopal episodes is performed. Read More

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http://dx.doi.org/10.19102/icrm.2018.090702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252686PMC

Risk Stratification of Sudden Cardiac Death After Acute Myocardial Infarction.

J Innov Card Rhythm Manag 2018 Feb 15;9(2):3035-3049. Epub 2018 Feb 15.

Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Despite advances in the diagnosis and treatment of acute coronary syndromes and an overall improvement in outcomes, mortality after myocardial infarction (MI) remains high. Sudden death, which is most frequently due to ventricular tachycardia or ventricular fibrillation, is the cause of death in 25% to 50% of patients with prior MI, and therefore represents an important public health problem. Use of the implantable cardioverter-defibrillator (ICD), which is the primary method of reducing the chance of arrhythmic sudden death after MI, is costly to the medical system and is associated with procedural and long-term risks. Read More

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http://dx.doi.org/10.19102/icrm.2018.090201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252689PMC
February 2018

Acute Water Ingestion as a Treatment for Postural Orthostatic Tachycardia Syndrome.

J Innov Card Rhythm Manag 2019 Feb 15;10(2):3541-3544. Epub 2019 Feb 15.

Department of Cardiology, Mercy Medical Center, Mason City, IA, USA.

A 24-year-old female presented to our clinic with symptomatic tachycardia. In the clinic, she was able to replicate her symptoms, which were due to tachycardia in a standing position that resolved upon sitting. The patient was then offered eight ounces (236. Read More

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http://dx.doi.org/10.19102/icrm.2019.100206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252788PMC
February 2019

There's no place like home? The psychological, physiological, and cognitive effects of short visits to outdoor urban environments compared to staying in the indoor home environment, a field experiment on women from two ethnic groups.

Environ Res 2020 May 21;187:109687. Epub 2020 May 21.

Department of Population Health, Azrieli Faculty of Medicine, Bar Ilan University, Safed,Israel. Electronic address:

Background: The home environment is regarded as a safe, comfortable environment, however, home can also be a stressful place. Compared to staying in the indoor home environment, the effects of short visits to outdoor urban environments on short-term psychological, physiological and cognitive responses were not studied previously.

Aim: To evaluate whether visits to different urban and ethnic environments, in comparison to staying in the home indoor environment, leads to short-term changes in psychological, physiological and cognitive responses and whether these responses are independent of ethnicity. Read More

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http://dx.doi.org/10.1016/j.envres.2020.109687DOI Listing

Effect of a lactate-guided conditioning program on heart rate variability obtained using 24-Holter electrocardiography in Beagle dogs.

PLoS One 2020 1;15(6):e0233264. Epub 2020 Jun 1.

Department of Animal Morphology and Physiology, Laboratory of Pharmacology and Equine Exercise Physiology (LAFEQ), School of Agricultural and Veterinarian Sciences (FCAV), São Paulo State University (UNESP), Jaboticabal, SP, Brazil.

The dogs' responses to training exercise are seldom monitored using physiological variables, and cardiac autonomic regulation (CAR) is a relevant determinant of endurance-training adaptation. There are studies in the literature establishing that regular exercise could interfere with CAR in dogs, measured by heart rate and vagal-derived indexes of heart-rate-variability (HRV). However, few studies were found using a prescribed training program based on the lactate threshold (LT) to determine HRV by a 24-h Holter analysis. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233264PLOS

Activation of Oxytocin Neurons Improves Cardiac Function in a Pressure-Overload Model of Heart Failure.

JACC Basic Transl Sci 2020 May 25;5(5):484-497. Epub 2020 May 25.

Department of Pharmacology and Physiology, George Washington University, Washington, DC.

This work shows long-term restoration of the hypothalamic oxytocin (OXT) network preserves OXT release, reduces mortality, cardiac inflammation, fibrosis, and improves autonomic tone and cardiac function in a model of heart failure. Intranasal administration of OXT in patients mimics the short-term changes seen in animals by increasing parasympathetic-and decreasing sympathetic-cardiac activity. This work provides the essential translational foundation to determine if approaches that mimic paraventricular nucleus (PVN) OXT neuron activation, such as safe, noninvasive, and well-tolerated intranasal administration of OXT, can be beneficial in patients with heart failure. Read More

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http://dx.doi.org/10.1016/j.jacbts.2020.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251188PMC

Evaluation of Fatigue in Cancer Patients in An Area Affected by The Great East Japan Earthquake.

Authors:
Daisuke Sato

Asia Pac J Oncol Nurs 2020 Apr-Jun;7(2):203-208. Epub 2020 Jan 14.

Department of Nursing, Faculty of Health Sciences, Komatsu University, Ishikawa, Japan.

Objective: The objective of this study is to evaluate fatigue in cancer outpatients receiving chemotherapy using an objective system and to clarify the type of nursing support needed after a disaster.

Methods: Based on the diagnostic criteria for chronic fatigue syndrome, the degree of subjective fatigue, autonomic function, and amount of physical activity were measured in cancer outpatients undergoing chemotherapy from an area affected by the Great East Japan Earthquake.

Results: The study participants were ten adults (8 men [80. Read More

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http://dx.doi.org/10.4103/apjon.apjon_52_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233562PMC
January 2020

The Autonomic Regulation of Tumor Growth and the Missing Links.

Front Oncol 2020 13;10:744. Epub 2020 May 13.

Department of Anatomy, Physiology, and Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.

Accumulating evidence now indicates that peripheral nerves and solid tumors mutually support the growth of each other. Tumor-derived molecular cues guide nerve infiltration to the tumor milieu, while the tumor-infiltrating nerves provide molecular support to promote tumor growth and dissemination. In this mini-review, we discuss the unique roles of sympathetic and parasympathetic nerves in promoting tumor growth and metastasis. Read More

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http://dx.doi.org/10.3389/fonc.2020.00744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237572PMC

Erectile dysfunction pre and post kidney transplant recipients in Duhok city; cross sectional study.

Ann Med Surg (Lond) 2020 Jul 16;55:107-110. Epub 2020 May 16.

Urologist, Duhok Directorate General of Health, Kurdistan Region, Iraq.

Introduction: Sexual dysfunction is a common problem in patients with chronic kidney disease. Disturbances in sexual function are noticed in early stages of chronic kidney diseases and deteriorate further as renal function declines. This is due to uremic effects, comorbid illness, anemia, hormonal disturbances, autonomic neuropathy, vascular diseases, hyperparathyroidism, hyperprolactinemia, side effects of medications, and psychosocial factors. Read More

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http://dx.doi.org/10.1016/j.amsu.2020.04.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251300PMC

Trans-Differentiation of Human Dental Pulp Stem Cells Into Cholinergic-Like Neurons Via Nerve Growth Factor.

Basic Clin Neurosci 2019 Nov-Dec;10(6):609-617. Epub 2019 Nov 1.

ENT and Head & Neck Research Center and Department, Hazrat Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

Introduction: Cell therapy has been widely considered as a therapeutic approach for neurodegenerative diseases and nervous system damage. Cholinergic neurons as one of the most important neurons that play a significant role in controlling emotions, mobility, and autonomic systems. In this study, Human Dental Pulp Stem Cells (hDPSCs) were differentiated into the cholinergic neurons by β-mercaptoethanol in the preinduction phase and also by the nerve growth factor (NGF) in the induction phase. Read More

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http://dx.doi.org/10.32598/bcn.10.6.609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253808PMC
November 2019

Fingolimod Leads to Immediate Immunological Changes Within 6 h After First Administration.

Front Neurol 2020 12;11:391. Epub 2020 May 12.

Department of Neurology, Center of Clinical Neuroscience, University Hospital Dresden, Dresden, Germany.

Multiple effects of fingolimod have already been described. Here we investigated the acute effects on immune cell subsets and identified correlations with autonomic first dose phenomena and long-term immunological effects. Blood samples of 20 MS patients were analyzed using FACS. Read More

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http://dx.doi.org/10.3389/fneur.2020.00391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235319PMC

Mindfulness-Based Student Training Leads to a Reduction in Physiological Evaluated Stress.

Front Psychol 2020 14;11:645. Epub 2020 May 14.

Institute of Innovative Health Technologies (IGHT), Ernst-Abbe-Hochschule Jena, Jena, Germany.

Background And Objective: In today's fast-paced modern lifestyle, chronic stress has become a serious issue with potential consequences for our physical and mental health. The concept of mindfulness and its derived Mindfulness-Based Stress Reduction (MBSR) program is considered to be an effective stress management technique for patients as well as for healthy persons. The effects of MBSR interventions on their participants have been subject of previous research, especially with regard to psychological or social science approaches using self-reports and questionnaires. Read More

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http://dx.doi.org/10.3389/fpsyg.2020.00645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240125PMC

Diurnal Patterns of Gene Expression in the Dorsal Vagal Complex and the Central Nucleus of the Amygdala - Non-rhythm-generating Brain Regions.

Front Neurosci 2020 11;14:375. Epub 2020 May 11.

Department of Pathology, Anatomy, and Cell Biology, Daniel Baugh Institute for Functional Genomics and Computational Biology, Thomas Jefferson University, Philadelphia, PA, United States.

Genes that establish the circadian clock have differential expression with respect to solar time in central and peripheral tissues. Here, we find circadian-time-induced differential expression in a large number of genes not associated with circadian rhythms in two brain regions lacking overt circadian function: the dorsal vagal complex (DVC) and the central nucleus of the amygdala (CeA). These regions primarily engage in autonomic, homeostatic, and emotional regulation. Read More

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http://dx.doi.org/10.3389/fnins.2020.00375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233260PMC

Effects and mechanisms of acupuncture and electroacupuncture for functional dyspepsia: A systematic review.

World J Gastroenterol 2020 May;26(19):2440-2457

Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, United States.

Background: Functional dyspepsia (FD) is a common digestive disease with limited therapeutic options. According to evidence-based clinical practice, acupuncture or electroacupuncture (EA) seems to be a promising therapy for patients with FD. However, there is still a lack of systematic reviews that have analyzed current clinical trials for a better understanding of mechanisms involved in the ameliorating effect of acupuncture and EA on FD. Read More

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http://dx.doi.org/10.3748/wjg.v26.i19.2440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243644PMC

Spontaneous Axonal Dystrophy in the Brain and Spinal Cord in Naïve Beagle Dogs.

Toxicol Pathol 2020 Jun 1:192623320926475. Epub 2020 Jun 1.

Global Pathology and Investigative Toxicology, Pfizer Inc, Groton, CT, USA.

Axonal dystrophy (AD) is a common age-related neurohistological finding in vertebrates that can be congenital or induced by xenobiotics, vitamin E deficiency, or trauma/compression. To understand the incidence and location of AD as a background finding in Beagle dogs used in routine toxicity studies, we examined central nervous system (CNS) and selected peripheral nervous system (PNS) tissues in twenty 18- to 24-month-old and ten 4- to 5-year-old control males and females. Both sexes were equally affected. Read More

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http://dx.doi.org/10.1177/0192623320926475DOI Listing

[Effects of strolling on the mind and autonomic activities of elderly people in the 2018 Yamaguchi Yume Flower Expo Well-being Garden based on the heart rate, blood pressure, low frequency/high frequency and mood].

Nihon Ronen Igakkai Zasshi 2020 ;57(2):155-162

Faculty of Health Sciences, Yamaguchi University Graduate School of Medicine Community/Gerontological Nursing.

Aim: In recent years in Japan, forest therapies have been implemented in various places. While the effects of such therapies have been reported in previous research papers, those of artificial gardens have not been clarified. At the 2018 Yamaguchi Yume Flower Expo, the Yamaguchi University Faculty of Medicine had the opportunity to provide a "Well-being Garden" in collaboration with the Japan Landscape Contractors Association Yamaguchi Prefecture Branch. Read More

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http://dx.doi.org/10.3143/geriatrics.57.155DOI Listing
January 2020

The use of whole-body cryotherapy: time- and dose-response investigation on circulating blood catecholamines and heart rate variability.

Eur J Appl Physiol 2020 May 30. Epub 2020 May 30.

Laboratoire MOVE (EA 6314), Faculté des Sciences du Sport, Université de Poitiers, Poitiers, France.

Purpose: A predominance of parasympathetic drive is observed following cold exposure. Such modulation of the autonomic nervous system (ANS) is associated with faster post-exercise recovery. Within this context, whole-body cryotherapy (WBC) has been spreading in sport medicine, though the optimal temperature and frequency are unclear. Read More

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http://dx.doi.org/10.1007/s00421-020-04406-5DOI Listing

Oxaliplatin-induced peripheral neuropathy: clinical features, mechanisms, prevention and treatment.

J Neurol 2020 May 30. Epub 2020 May 30.

Department of Histology and Embryology, Medical College, Nanchang University, Bayi Road 461, Nanchang, 330006, China.

Oxaliplatin (OXA) is a commonly used platinum-based chemotherapy drug for colorectal cancer. OXA-induced peripheral neurotoxcity (OIPN) is a comprehensive adverse reaction of OXA. OIPN can be divided into acute and chronic types according to clinical features and different mechanisms. Read More

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http://dx.doi.org/10.1007/s00415-020-09942-wDOI Listing