67,058 results match your criteria Automatic External Defibrillation


[Current trends in flexible ureteroscopy: an update].

Aktuelle Urol 2018 Dec 12. Epub 2018 Dec 12.

Department of Urology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg.

Flexible ureteroscopy (fURS) has become a success story in urology. Since its implementation into the treatment of urolithiasis, fURS has demonstrated excellent clinical performance and safety. In recent years, the spread of disposable ureteroscopes has shaped the field of endoscopic stone treatment. Read More

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December 2018

A recursive ensemble organ segmentation (REOS) framework: application in brain radiotherapy.

Phys Med Biol 2018 Dec 12. Epub 2018 Dec 12.

Department of Radiation Oncology, University of Texas Southwestern Medical Centre, Dallas, TX 75235, Dallas, Texas, 75205, UNITED STATES.

The aim of this work is to develop a novel recursive ensemble OARs segmentation (REOS) framework for accurate organs-at-risk (OARs) automatic segmentation. The REOS recursively segment individual OARs by ensembling images features extracted from an organ localization module and a contour detection module. Both modules are based on a 3D U-Net architecture. Read More

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December 2018

Can a high-density dental material affect the automatic exposure compensation of digital radiographic images?

Dentomaxillofac Radiol 2018 Dec 12:20180331. Epub 2018 Dec 12.

1 Department of Oral Diagnosis, Division of Oral Radiology,, Piracicaba Dental School, University of Campinas (UNICAMP) , Sao Paulo , Brazil.

Objective:: To investigate the influence of high-density dental material on the automatic exposure compensation (AEC) of digital radiographic imaging systems.

Methods:: Two radiographic phantoms were custom made to reproduce radiographic densities of the dental tissues: enamel, dentin and pulp chamber. The phantoms were X-rayed using the Digora Toto, Digora Optime and VistaScan systems for 0. Read More

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December 2018

Exploring the influence from whole blood DNA extraction methods on Infinium 450K DNA methylation.

PLoS One 2018 12;13(12):e0208699. Epub 2018 Dec 12.

Department of Pediatric Oncology and Hematology, Oslo University Hospital, Oslo, Norway.

Genome-wide DNA methylation studies are becoming increasingly important in unraveling the epigenetic basis of cell biology, aging and human conditions. The aim of the present study was to explore whether different methods for extracting DNA from whole blood can affect DNA methylation outcome, potentially confounding DNA methylation studies. DNA was isolated from healthy blood donors (n = 10) using three different extraction methods (i. Read More

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December 2018

A secure heterogeneous mobile authentication and key agreement scheme for e-healthcare cloud systems.

Authors:
Han-Yu Lin

PLoS One 2018 12;13(12):e0208397. Epub 2018 Dec 12.

Department of Computer Science and Engineering, National Taiwan Ocean University, Keelung, Taiwan.

Heterogeneous mobile authentication is a crucial technique to securely retrieve the resource of e-healthcare cloud servers which are commonly implemented in a public key Infrastructure (PKI). Conventionally, a mobile data user can utilize a self-chosen password along with a portable device to request the access privilege of clouds. However, to validate the membership of users, a cloud server usually has to make use of a password table, which not only increases the burden of management, but also raises the possibility of information leakage. Read More

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December 2018

Dealing with flawed items in examinations: Using the compensation of disadvantage as used in German state examinations in items with partial credit scoring.

Authors:
Andreas Möltner

GMS J Med Educ 2018 15;35(4):Doc49. Epub 2018 Nov 15.

Medizinische Fakultät Heidelberg, Kompetenzzentrum für Prüfungen in der Medizin, Heidelberg, Germany.

In the written part of German state exams, multiple choice questions which inherit a flaw are not always excluded but taken into consideration when awarding a grade to any individual candidate, if this is advantageous to the candidate. This process of elimination and compensation of disadvantage in flawed questions, as applied by the Institut für medizinische und pharmazeutische Prüfungsfragen (IMPP), can lead to being taken into consideration in the grading and to the application of . This procedure is applied here to examinations containing items with partial credit scoring. Read More

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November 2018

Reference Intervals of Thyroid Hormones and Correlation of BMI with Thyroid Function in Healthy Zhuang Ethnic Pregnant Women.

Biomed Res Int 2018 14;2018:2032413. Epub 2018 Nov 14.

Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China.

Ethnic differences in the level of thyroid hormones exist among individuals. The American Thyroid Association (ATA) recommends that an institution or region should establish a specific thyroid hormone reference value for each stage of pregnancy. To date, a limited number of studies have reported the level of thyroid hormones in Chinese minorities, and the exact relationship between BMI and thyroid function in pregnant women is ill. Read More

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November 2018

Arrhythmia Classification of ECG Signals Using Hybrid Features.

Comput Math Methods Med 2018 12;2018:1380348. Epub 2018 Nov 12.

Department of Nuclear Engineering, King Abdulaziz University, Jeddah, Saudi Arabia.

Automatic detection and classification of life-threatening arrhythmia plays an important part in dealing with various cardiac conditions. In this paper, a novel method for classification of various types of arrhythmia using morphological and dynamic features is presented. Discrete wavelet transform (DWT) is applied on each heart beat to obtain the morphological features. Read More

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November 2018

Impact of Physical and Cognitive Exertion on Cognitive Control.

Front Psychol 2018 27;9:2369. Epub 2018 Nov 27.

LAMHESS, Université Côte d'Azur, Nice, France.

In a recent study, the differential effects of prolonged physiologically challenging exercise upon two executive processes (cognitive control and working memory) were investigated. However, the impact of exercise on the selective inhibition task employed was debatable and needed further analysis to dissociate the effects induced by exercise intensity from those induced by the time spent on task upon cognitive control outcomes. In this study, we propose a thorough analysis of these data, using a generalized mixed model on a trial-by-trial basis and a new measure of the strength of the automatic response based on reaction time distribution, to disentangle the effect of physical fatigue from cognitive fatigue. Read More

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November 2018

Visual-Somatosensory Integration and Quantitative Gait Performance in Aging.

Front Aging Neurosci 2018 27;10:377. Epub 2018 Nov 27.

Division of Cognitive and Motor Aging, Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, United States.

The ability to integrate information across sensory modalities is an integral aspect of mobility. Yet, the association between visual-somatosensory (VS) integration and gait performance has not been well-established in aging. A total of 333 healthy older adults (mean age 76. Read More

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November 2018

Improving palliative care with deep learning.

BMC Med Inform Decis Mak 2018 Dec 12;18(Suppl 4):122. Epub 2018 Dec 12.

Center for Biomedical Informatics Research, Stanford University, Stanford, CA, USA.

Background: Access to palliative care is a key quality metric which most healthcare organizations strive to improve. The primary challenges to increasing palliative care access are a combination of physicians over-estimating patient prognoses, and a shortage of palliative staff in general. This, in combination with treatment inertia can result in a mismatch between patient wishes, and their actual care towards the end of life. Read More

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December 2018

Compile- and run-time approaches for the selection of efficient data structures for dynamic graph analysis.

Appl Netw Sci 2016 5;1(1). Epub 2016 Sep 5.

1Privacy and Data Security, Department of Computer Science, TU Dresden, Nöthnitzer Straße 46, Dresden, 01187 Germany.

Graphs are used to model a wide range of systems from different disciplines including social network analysis, biology, and big data processing. When analyzing these constantly changing dynamic graphs at a high frequency, performance is the main concern. Depending on the graph size and structure, update frequency, and read accesses of the analysis, the use of different data structures can yield great performance variations. Read More

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September 2016

Functional mapping of N deficiency-induced response in wheat yield-component traits by implementing high-throughput phenotyping.

Plant J 2018 Dec 7. Epub 2018 Dec 7.

Center for Statistical Genetics, The Pennsylvania State University, Hershey, PA, 17033, USA.

As overfertilization leads to environmental concerns and the cost of N-fertilizer increases, the issue of how to select crop cultivars that can produce high yield on N-deficient lands has become crucially important. However, little is known about the genetic mechanisms by which crops respond to environmental changes induced by N signaling. Here, we dissected the genetic architecture of N-induced phenotypic plasticity in bread wheat (Triticum aestivum L. Read More

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December 2018
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ARENA: Inter-modality affine registration using evolutionary strategy.

Int J Comput Assist Radiol Surg 2018 Dec 10. Epub 2018 Dec 10.

PERFORM Centre, Concordia University, Montreal, Canada.

Purpose: Image fusion of different imaging modalities renders valuable information to clinicians. In this paper, we proposed an automatic multimodal registration method to register intra-operative ultrasound images (US) to preoperative magnetic resonance images (MRI) in the context of image-guided neurosurgery.

Methods: We employed refined correlation ratio as a similarity metric for our intensity-based image registration method. Read More

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December 2018

Automatic coronary blood flow computation: validation in quantitative flow ratio from coronary angiography.

Int J Cardiovasc Imaging 2018 Dec 8. Epub 2018 Dec 8.

Biomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.

To assess a novel approach for automatic flow velocity computation in deriving quantitative flow ratio (QFR) from coronary angiography. QFR is a novel approach for assessment of functional significance of coronary artery stenosis without using pressure wire and induced hyperemia. Patient-specific coronary flow is estimated semi-automatically by frame count method, which is subjective and inconvenient in the workflow of QFR analysis. Read More

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December 2018

Automatic and semi-automatic assignment and fitting of spectra with PGOPHER.

Phys Chem Chem Phys 2018 Dec 11. Epub 2018 Dec 11.

Canadian Light Source, University of Saskatchewan, Canada.

Two new tools for computer assisted assignment of rotational spectra with the PGOPHER program are presented, aimed particularly at spectra where many individual lines are resolved. The first tool tries many different assignments, presenting a small number for possible refinement and a preliminary version of this has already been presented. The second tool, the nearest lines plot (a new style of residual plot) provides a clear indication as to whether a trial calculation is plausible, and allows rapid assignment of sets of related lines. Read More

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December 2018

Automated adherent cell elimination by a high-speed laser mediated by a light-responsive polymer.

Commun Biol 2018 7;1:218. Epub 2018 Dec 7.

4Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 5th, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565 Japan.

Conventional cell handling and sorting methods require manual labor, which decreases both cell quality and quantity. To purify adherent cultured cells, cell purification technologies that are high throughput without dissociation and can be utilized in an on-demand manner are expected. Here, we developed a Laser-induced, Light-responsive-polymer-Activated, Cell Killing (LiLACK) system that enables high-speed and on-demand adherent cell sectioning and purification. Read More

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December 2018

Xolotl: An Intuitive and Approachable Neuron and Network Simulator for Research and Teaching.

Front Neuroinform 2018 26;12:87. Epub 2018 Nov 26.

Volen National Center for Complex Systems and Biology Department, Brandeis University, Waltham, MA, United States.

Conductance-based models of neurons are used extensively in computational neuroscience. Working with these models can be challenging due to their high dimensionality and large number of parameters. Here, we present a neuron and network simulator built on a novel automatic type system that binds object-oriented code written in C++ to objects in MATLAB. Read More

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November 2018

Comparative (Quantitative and Qualitative) Analysis of Three Different Reagents for Preparation of Platelet-Rich Plasma for Hair Rejuvenation.

Authors:
Sukhbir Singh

J Cutan Aesthet Surg 2018 Jul-Sep;11(3):127-131

Resplendent the cosmetic studio, R-9, GK Part 1, New Delhi-48.

Objective: The aim of this study was to compare the quantity and quality of platelets in platelet-rich plasma (PRP) samples prepared using three different reagents, namely, ethylenediaminetetraacetic acid (EDTA), sodium citrate, and acid citrate dextrose-A (ACD-A) solution.

Materials And Methods: A prospective study was carried out in which all the 50 patients who attended the outpatient department for hair rejuvenation were enrolled for the study. All the patients had a history of hair fall with diffuse thinning of hair, Norwood Grades 2 and 3. Read More

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December 2018

Automated phosphopeptide enrichment from minute quantities of frozen malignant melanoma tissue.

PLoS One 2018 10;13(12):e0208562. Epub 2018 Dec 10.

Clinical Protein Science & Imaging, Department of Clinical Sciences (Lund), Department of Biomedical Engineering, Lund University, Lund, Sweden.

To acquire a deeper understanding of malignant melanoma (MM), it is essential to study the proteome of patient tissues. In particular, phosphoproteomics of MM has become of significant importance because of the central role that phosphorylation plays in the development of MM. Investigating clinical samples, however, is an extremely challenging task as there is usually only very limited quantities of material available to perform targeted enrichment approaches. Read More

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December 2018

Analysis of Shear Flow-induced Migration of Murine Marginal Zone B Cells In Vitro.

J Vis Exp 2018 Nov 26(141). Epub 2018 Nov 26.

Institute of Biochemistry and Cell Biology, OVGU University of Magdeburg;

Marginal zone B cells (MZBs) are a population of B cells that reside in the mouse splenic marginal zones that envelop follicles. To reach the follicles, MZBs must migrate up the shear force of blood flow. We present here a method for analyzing this flow-induced MZB migration in vitro. Read More

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November 2018

Endogenous automatic nerve discharge promotes nerve repair: an optimized animal model.

Neural Regen Res 2019 Feb;14(2):306-312

Department of Hand Surgery, Huashan Hospital, Fudan University; Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, Shanghai, China.

Exogenous electrical nerve stimulation has been reported to promote nerve regeneration. Our previous study has suggested that endogenous automatic nerve discharge of the phrenic nerve and intercostal nerve has a positive effect on nerve regeneration at 1 month postoperatively, but a negative effect at 2 months postoperatively, which may be caused by scar compression. In this study, we designed four different rat models to avoid the negative effect from scar compression. Read More

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February 2019

Label-efficient Breast Cancer Histopathological Image Classification.

IEEE J Biomed Health Inform 2018 Dec 5. Epub 2018 Dec 5.

The automatic classification of breast cancer histopathological images has great significance in computer-aided diagnosis. Recently, deep learning via neural networks has enabled pattern detection and prediction using large, labeled datasets; whereas, collecting and annotating sufficient histological data using professional pathologists is time-consuming, tedious, and extremely expensive. In the proposed work, a deep active learning framework is designed and implemented for classification of breast cancer histopathological images, with the goal of maximizing the learning accuracy from very limited labeling. Read More

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December 2018

Weakly-Supervised Lesion Detection from Fundus Images.

IEEE Trans Med Imaging 2018 Dec 6. Epub 2018 Dec 6.

Early diagnosis and continuous monitoring of patients suffering from eye diseases have been major concerns in the computer-aided detection (CAD) techniques. Detecting one or several specific types of retinal lesions has made a significant breakthrough in computed-aid screen in the past few decades. However, due to variety of retinal lesions and complex normal anatomical structures, automatic detection of lesions with unknown and diverse types from a retina remains a challenging task. Read More

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December 2018

Automatic Detection of B-lines in In-Vivo Lung Ultrasound.

IEEE Trans Ultrason Ferroelectr Freq Control 2018 Dec 10. Epub 2018 Dec 10.

This paper proposes an automatic method for accurate detection and visualization of B-lines in ultrasound lung scans, which provides a quantitative measure for the number of Blines present. All the scans used in this study were acquired using a BK3000 ultrasound scanner (BK Ultrasound, Denmark) driving a 5.5 MHz linear transducer (BK Ultrasound). Read More

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December 2018

Unsupervised two-path neural network for cell event detection and classification using spatio-temporal patterns.

IEEE Trans Med Imaging 2018 Dec 7. Epub 2018 Dec 7.

Automatic event detection in cell videos is essential for monitoring cell populations in biomedicine. Deep learning methods have advantages over traditional approaches for cell event detection due to their ability to capture more discriminative features of cellular processes. Supervised deep learning methods however are inherently limited due to the scarcity of annotated data. Read More

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December 2018

Synthesis of 8-hydroxyquinoline glycoconjugates and preliminary assay of their β1,4-GalT inhibitory and anti-cancer properties.

Bioorg Chem 2018 Nov 24;84:326-338. Epub 2018 Nov 24.

Institute of Chemistry, University of Silesia, Szkolna 9, 40-006 Katowice, Poland.

8-Hydroxyquinoline scaffold is a privileged structure used in designing a new active agents with therapeutic potential. Its connections with the sugar unit is formed to improve the pharmacokinetic properties. The broad spectrum of activity of quinoline derivatives, especially glycoconjugates, is often associated with the ability to chelate metal ions or with the ability to intercalate into DNA. Read More

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November 2018

Determining groundwater recharge and vapor flow in dune sediments using a weighable precision meteo lysimeter.

Sci Total Environ 2018 Nov 28;656:550-557. Epub 2018 Nov 28.

Instituto Geológico y Minero de España, Rios Rosas 23, 28003 Madrid, Spain.

Dune belts are crucial for the recharge of coastal aquifers. In spite of their hydrological relevance for the maintenance of precious natural wetland and wildlife environments and a range of other ecosystem services, only limited knowledge of soil water dynamics in dune belts is currently available. This study presents soil water balance components measured during one hydrological year using a high precision meteo-lysimeter with lower boundary control installed in a coastal dune belt under a dry subhumid climate in southern Spain close to the Atlantic Ocean. Read More

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November 2018

Computing neurite outgrowth and arborization in superior cervical ganglion neurons.

Brain Res Bull 2018 Dec 6. Epub 2018 Dec 6.

Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, United States; Medical Investigations of Neurodevelopmental Disorders (MIND) Institute, University of California Davis, CA 95817, United States. Electronic address:

Dendrites are the primary site of synaptic activity in neurons and changes in synapses are often the first pathological stage in neurodegenerative diseases. Molecular studies of these changes rely on morphological analysis of the imaging of somas and dendritic arbors of cultured or primary neurons. As research on preventing or reversing synaptic degeneration develops, demands increase for user-friendly 2D neurite analyzers without undermining accuracy and reproducibility. Read More

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December 2018

Ground truth construction and parameter tuning for the detection of sleep spindle timing in rodents.

J Neurosci Methods 2018 Dec 7. Epub 2018 Dec 7.

Psychology Department, University of Arizona, Tucson, Arizona, United States; Biomedical Engineering Department, University of Arizona, Tucson, Arizona, United States; Program in Applied Mathematics, University of Arizona, Tucson, Arizona, United States. Electronic address:

Background: The precise detection of cortical sleep spindles is critical to basic research on memory consolidation in rodents. Previous research using automatic spindle detection algorithms often lacks systematic parameter variations and validations.

New Method: We present a method to systematically tune and validate algorithm parameters in automatic spindle detection algorithms using a moderate number of human raters. Read More

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December 2018

Spatially matching morphometric assessment of cartilage and subchondral bone in osteoarthritic human knee joint with micro-computed tomography.

Bone 2018 Dec 7. Epub 2018 Dec 7.

SCANCO Medical AG, Brüttisellen, Switzerland; Department of Research and Development, Schulthess Klinik, Zürich, Switzerland. Electronic address:

Objective: The objective of this study was to develop a reproducible and semi-automatic method based on micro computed tomography (microCT) to analyze cartilage and bone morphology of human osteoarthritic knee joints in spatially matching regions of interest.

Materials And Methods: Tibial plateaus from randomly selected patients with advanced osteoarthritis (OA) who underwent total knee arthroplasty surgery were microCT scanned once fresh and once after staining with Hexabrix. The articular surface was determined manually in the first scan. Read More

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December 2018

Automatic screening using word embeddings achieved high sensitivity and workload reduction for updating living network meta-analyses.

J Clin Epidemiol 2018 Dec 7. Epub 2018 Dec 7.

Centre de Recherche Epidémiologie et Statistique Paris Sorbonne Cité, INSERM U1153, Paris, France; Université Paris Descartes - Sorbonne Paris cité, Paris, France; Centre d'Epidémiologie Clinique, Assistance Publique-Hôpitaux de Paris, Hôpital Hôtel-Dieu, Paris, France. Electronic address:

Objective: We aimed to develop and evaluate an algorithm for automatically screening citations when updating living network meta-analysis (NMA).

Study Design And Setting: Our algorithm learns from the initial screening of citations conducted when creating an NMA to automatically identify eligible citations (i.e. Read More

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December 2018

Bimodal classification algorithm for atrial fibrillation detection from m-health ECG recordings.

Comput Biol Med 2018 Nov 22. Epub 2018 Nov 22.

Neural Engineering, National Institute of Neurological Disorders and Stroke, National Institute of Health, Bethesda, MD, USA; Center for Arrhythmia Research, University of Michigan, Ann Arbor, MI, USA.

Introduction: Atrial Fibrillation (AF) is the most common cardiac arrhythmia, presenting a significant independent risk factor for stroke and thromboembolism. With the emergence of m-Health devices, the importance of automatic detection of AF in an off-clinic setting is growing. This study demonstrates the performance of a bimodal classifier for distinguishing AF from sinus rhythm (SR) that could be used for automated detection of AF episodes. Read More

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November 2018

Translational Study on Recurrent Laryngeal Nerve Temperature Susceptibility.

J Surg Res 2019 Feb 27;234:7-12. Epub 2018 Sep 27.

Division for Endocrine Surgery, Department of Human Pathology in Adulthood and Childhood "G. Barresi," University Hospital G. Martino, University of Messina, Messina, Italy.

Background: Recurrent laryngeal nerve (RLN) injury is the most common and serious complication after thyroid surgery. However, little is known about the temperature threshold leading to RLN injury. In this study, we investigated threshold temperatures that cause RLN injury during thyroid surgery using continuous intraoperative neuromonitoring in swine models. Read More

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February 2019

Increased take-off level in automatic milking systems - effects on milk flow, milk yield and milking efficiency at the quarter level.

J Dairy Res 2018 Dec 11:1-3. Epub 2018 Dec 11.

Department of Animal Science,Aarhus University,Blichers Allé 20, P.O. Box 50, DK-8830 Tjele,Denmark.

This research communication describes how different detachment levels (0.48, 0.3 and 0. Read More

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December 2018

Mining and standardizing chinese consumer health terms.

BMC Med Inform Decis Mak 2018 Dec 7;18(Suppl 5):120. Epub 2018 Dec 7.

Institute of Medical Information, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, 100020, China.

Background: Health professionals and consumers use different terms to express medical events or concerns, which makes the communication barriers between the professionals and consumers. This may lead to bias in the diagnosis or treatment due to the misunderstanding or incomplete understanding. To solve the issue, a consumer health vocabulary was developed to map the consumer-used health terms to professional-used medical terms. Read More

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December 2018

Automatic seizure detection using three-dimensional CNN based on multi-channel EEG.

BMC Med Inform Decis Mak 2018 Dec 7;18(Suppl 5):111. Epub 2018 Dec 7.

Department of Biomedical Engineering, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, Guangdong Province, China.

Background: Automated seizure detection from clinical EEG data can reduce the diagnosis time and facilitate targeting treatment for epileptic patients. However, current detection approaches mainly rely on limited features manually designed by domain experts, which are inflexible for the detection of a variety of patterns in a large amount of patients' EEG data. Moreover, conventional machine learning algorithms for seizure detection cannot accommodate multi-channel Electroencephalogram (EEG) data effectively, which contains both temporal and spatial information. Read More

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December 2018

Automatic gene annotation using GO terms from cellular component domain.

BMC Med Inform Decis Mak 2018 Dec 7;18(Suppl 5):119. Epub 2018 Dec 7.

Department of Computer and Information Science, University of Delaware, Newark, DE, 19716, USA.

Background: The Gene Ontology (GO) is a resource that supplies information about gene product function using ontologies to represent biological knowledge. These ontologies cover three domains: Cellular Component (CC), Molecular Function (MF), and Biological Process (BP). GO annotation is a process which assigns gene functional information using GO terms to relevant genes in the literature. Read More

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December 2018

Impact of linkage quality on inferences drawn from analyses using data with high rates of linkage errors in rural Tanzania.

BMC Med Res Methodol 2018 Dec 10;18(1):165. Epub 2018 Dec 10.

Department of Population Health, Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.

Background: Studies based on high-quality linked data in developed countries show that even minor linkage errors, which occur when records of two different individuals are erroneously linked or when records belonging to the same individual are not linked, can impact bias and precision of subsequent analyses. We evaluated the impact of linkage quality on inferences drawn from analyses using data with substantial linkage errors in rural Tanzania.

Methods: Semi-automatic point-of-contact interactive record linkage was used to establish gold standard links between community-based HIV surveillance data and medical records at clinics serving the surveillance population. Read More

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December 2018

Improving Vibrational Mode Interpretation Using Bayesian Regression.

J Chem Theory Comput 2018 Dec 10. Epub 2018 Dec 10.

In order to streamline the interpretation of vibrational spectra, this work introduces the use of Bayesian linear regression with automatic relevance determination as a viable approach to decompose the atomic motions along any vibrational mode as a weighted combination of displacements along chemically meaningful internal coordinates. This novel approach denominated Vibrational Mode Automatic Relevance Determination (VMARD) is presented and compared with the well established Potential Energy Decomposition (PED) scheme. Good agreement is generally attained between the two methods. Read More

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December 2018

Gliquidone Alleviates Diabetic Nephropathy by Inhibiting Notch/Snail Signaling Pathway.

Cell Physiol Biochem 2018 6;51(5):2085-2097. Epub 2018 Dec 6.

Background/aims: Diabetic nephropathy is a common complication of diabetes. This study explored the renal protective effect and possible mechanism of gliquidone in mice with diabetic nephropathy.

Methods: Animal model of diabetic nephropathy was established in KKAy mice. Read More

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December 2018
3 Reads

Disruption of function: Neurophysiological markers of cognitive deficits in retired football players.

Clin Neurophysiol 2018 Nov 26;130(1):111-121. Epub 2018 Nov 26.

Department of Linguistics and Languages, McMaster University, Togo Salmon Hall 513, 1280 Main Street, West Hamilton, ON L8S 4M2, Canada; ARiEAL Research Centre, McMaster University, L.R. Wilson Hall, 1280 Main Street, West Hamilton, ON L8S 4M2, Canada; School of Biomedical Engineering, McMaster University, ETB-406, 1280 Main St., West Hamilton, ON L8S 4K1, Canada; MaRS Centre, Vector Institute, Canada; McMaster University, Department of Psychology, Neuroscience and Behaviour, Canada. Electronic address:

Objective: Recent studies demonstrate that sports-related concussions can have negative consequences on long-term brain health. The goal of the present study was to determine whether retired Canadian Football League (CFL) athletes with a history of concussions exhibit alterations in neurocognitive functioning, along with changes in physical, social, and psychological health.

Methods: Our study compared nineteen retired CFL athletes' concussion histories to eighteen healthy age-matched controls with no history of concussion. Read More

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November 2018
2 Reads

Factors of local recurrence and organ preservation with transoral laser microsurgery in laryngeal carcinomas; CHAID decision-tree analysis.

Head Neck 2018 Dec 6. Epub 2018 Dec 6.

Otolaryngology Department, Hospital Clínic, Barcelona, Spain.

Background: Indications of transoral laser microsurgery (TLM) are conditioned by the risk of local relapse.

Objective: To evaluate prognostic factors of local relapse and local control with TLM (LC-TLM).

Methods: Local relapse and LC-TLM were evaluated in 1119 patients. Read More

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December 2018

Neural correlates of the effect of implementation intention on prospective memory.

Psych J 2018 Dec 5. Epub 2018 Dec 5.

Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China.

Prospective memory (PM) refers to the ability to remember to do something in the future. Implementation intention refers to a self-regulatory strategy in the form of "If …, then …" planning that can improve PM performance. However, the neural basis of the effect of implementation intention on PM remains unclear, as do the phases of PM that are affected by implementation intention. Read More

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December 2018
2 Reads

Targeted Feature Extraction in MALDI Mass Spectrometry Imaging to Discriminate Proteomic Profiles of Breast and Ovarian Cancer.

Proteomics Clin Appl 2018 Dec 6:e1700168. Epub 2018 Dec 6.

University of Bremen, Bremen, Germany.

Purpose: To develop a mass spectrometry imaging (MSI) based workflow for extracting m/z values related to putative protein biomarkers and using these for reliable tumor classification.

Experimental Design: Given a list of putative breast and ovarian cancer biomarker proteins, we extracted a set of related m/z values from heterogeneous MSI datasets derived from formalin-fixed paraffin-embedded tissue material. Based on these features, a linear discriminant analysis classification model was trained to discriminate the two tumor types. Read More

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December 2018

Automated segmentation of trabecular and cortical bone from proton density weighted MRI of the knee.

Med Biol Eng Comput 2018 Dec 5. Epub 2018 Dec 5.

Department of Biomechanical Engineering, University of Twente, Drienerlolaan 5, 7500 AE, Enschede, the Netherlands.

Patient-specific implant design and pre- and intra-operative planning is becoming increasingly important in the orthopaedic field. For clinical feasibility of these techniques, fast and accurate segmentation of bone structures from MRI is essential. However, manual segmentation is time intensive and subject to inter- and intra-observer variation. Read More

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December 2018
1 Read

Automatic detection of perforator vessels using infrared thermography in reconstructive surgery.

Int J Comput Assist Radiol Surg 2018 Dec 5. Epub 2018 Dec 5.

Innovation Center Computer Assisted Surgery, University Leipzig, Semmelweisstr. 14, 04103, Leipzig, Germany.

Purpose: Knowing the location of the blood vessels supplying the skin and subcutaneous tissue is a requirement during the planning of tissue transfer in reconstructive surgery. Commonly used imaging techniques such as computed tomography angiography and indocyanine green angiography expose the patient to radiation or a contrast agent, respectively. Infrared thermal imaging was evaluated with success as a non-invasive alternative. Read More

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December 2018
3 Reads

Automatic Seizure Detection Based on Nonlinear Dynamical Analysis of EEG Signals and Mutual Information.

Basic Clin Neurosci 2018 Jul-Aug;9(4):227-240. Epub 2018 Jul 1.

Department of Bioelectrical Engineering, School of Electrical Engineering, Iran University of Science and Technology, Tehran, Iran.

Introduction: In this paper, nonlinear dynamical analysis based on Recurrence Quantification Analysis (RQA) is employed to characterize the nonlinear EEG dynamics. RQA can provide useful quantitative information on the regular, chaotic, or stochastic property of the underlying dynamics.

Methods: We use the RQA-based measures as the quantitative features of the nonlinear EEG dynamics. Read More

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Voxel-based automatic multi-criteria optimization for intensity modulated radiation therapy.

Radiat Oncol 2018 Dec 5;13(1):241. Epub 2018 Dec 5.

Department of Biomedical Engineering, Southern Medical University, Guangzhou, 510515, Guangdong, China.

Background: Automatic multi-criteria optimization is necessary for intensity modulated radiation therapy (IMRT) because of low planning efficiency and large plan quality uncertainty in current clinical practice. Most studies focused on imitating dosimetrists' planning procedures to automate this process and ignored the fact that organ-based objective functions typically used in commercial treatment planning systems (such as dose-volume function) usually lead to sub-optimal plans. To guarantee the optimum results and to automate this process, we incorporate an improved automation strategy and a voxel-based optimization algorithm to generate a novel automatic multi-criteria optimization framework. Read More

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December 2018