150,098 results match your criteria Automated Software Engineering[Journal]

Comparison of Visual Evoked Potentials in Patients Affected by Optic Neuritis From Multiple Sclerosis or Neuromyelitis Optica Spectrum Disorder.

J Neuroophthalmol 2021 Jul 27. Epub 2021 Jul 27.

Laboratory of Investigation in Ophthalmology (LIM 33) (TGF, MKO, KH, LPC, MLRM), Division of Ophthalmology, University of São Paulo Medical School, São Paulo, Brazil; Department of Ophthalmology (KH), Federal University of Paraná, Curitiba, Paraná, Brazil; Department of Ophthalmology (LPC), Federal University of Juiz de Fora Medical School, Juiz de Fora, Minas Gerais, Brazil; and Department of Neurology (SLA-P, DC), University of São Paulo Medical School, São Paulo, Brazil.

Purpose: To compare the visual evoked potentials (VEPs) of optic neuritis (ON) patients with multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and controls. To evaluate correlations between VEP and optical coherence tomography (OCT), contrast sensitivity (CS), and automated perimetry.

Methods: Fifty-five eyes with ON from 29 patients (MS = 14 and NMOSD = 15) and 57 eyes from 29 controls were evaluated using VEP, automated perimetry, CS, and optical coherence tomography. Read More

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PONT: A Protocol for Online Neuropsychological Testing.

J Cogn Neurosci 2021 Jul 29:1-13. Epub 2021 Jul 29.

University of California.

A major challenge for neuropsychological research arises from the fact that we are dealing with a limited resource: the patients. Not only is it difficult to identify and recruit these individuals, but their ability to participate in research projects can be limited by their medical condition. As such, sample sizes are small, and considerable time (e. Read More

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Petrological and geochemical characterisation of the sarsen stones at Stonehenge.

PLoS One 2021 4;16(8):e0254760. Epub 2021 Aug 4.

Gatan UK, Abingdon, Oxfordshire, United Kingdom.

Little is known of the properties of the sarsen stones (or silcretes) that comprise the main architecture of Stonehenge. The only studies of rock struck from the monument date from the 19th century, while 20th century investigations have focussed on excavated debris without demonstrating a link to specific megaliths. Here, we present the first comprehensive analysis of sarsen samples taken directly from a Stonehenge megalith (Stone 58, in the centrally placed trilithon horseshoe). Read More

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Linear Model Identification for Personalized Prediction and Control in Diabetes.

IEEE Trans Biomed Eng 2021 Aug 4;PP. Epub 2021 Aug 4.

Objective: Type-1 diabetes (T1D) is a metabolic disease, characterized by impaired blood glucose (BG) regulation, which forces patients to multiple daily therapeutic actions, the most critical of which is exogenous insulin administration. T1D management can considerably benefit of mathematical models enabling accurate BG predictions and effective/safe automated insulin delivery. In building these models, dealing with large inter- and intra-patient variability in glucose-insulin dynamics represents a major challenge. Read More

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Performance of a Convolutional Neural Network and Explainability Technique for 12-Lead Electrocardiogram Interpretation.

JAMA Cardiol 2021 Aug 4. Epub 2021 Aug 4.

RISE Lab, Department of Electrical Engineering and Computer Science, University of California, Berkeley, Berkeley.

Importance: Millions of clinicians rely daily on automated preliminary electrocardiogram (ECG) interpretation. Critical comparisons of machine learning-based automated analysis against clinically accepted standards of care are lacking.

Objective: To use readily available 12-lead ECG data to train and apply an explainability technique to a convolutional neural network (CNN) that achieves high performance against clinical standards of care. Read More

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Improving geocoding matching rates of structured addresses in Rio de Janeiro, Brazil.

Cad Saude Publica 2021 28;37(7):e00039321. Epub 2021 Jul 28.

Instituto de Medicina Social, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brasil.

Strategies for improving geocoded data often rely on interactive manual processes that can be time-consuming and impractical for large-scale projects. In this study, we evaluated different automated strategies for improving address quality and geocoding matching rates using a large dataset of addresses from death records in Rio de Janeiro, Brazil. Mortality data included 132,863 records with address information in a structured format. Read More

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Exploring the Expression Differences Between Professionals and Laypeople Toward the COVID-19 Vaccine: A Text Mining Approach.

J Med Internet Res 2021 Aug 1. Epub 2021 Aug 1.

School of Journalism and Communication, Tsinghua University, 30 Shuangqing Road, Haidian District, Beijing, Beijing, CN.

Background: COVID-19 is still rampant all over the world. Until now, the COVID-19 vaccine is the most promising measure to subdue contagion and achieve herd immunity. However, public vaccination intention is suboptimal. Read More

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Influence of sample preparation optimization on the accuracy of dose assessment of an automatic non-fluorescent MN scoring system.

Int J Radiat Biol 2021 Aug 4:1-45. Epub 2021 Aug 4.

Institute of Nuclear Techniques, Budapest University of Technology and Economics, Budapest, Hungary.

Automatizing the scoring of the cytokinesis-blocked micronucleus assay spares a lot of valuable time. The dose-effect relationship can be applied reliably for dose estimation, if the quality of the slides is the same from the perspective of the used image processing algorithm. This aspect brings in additional requirements against the quality of the slides compared to the conventional visual scoring. Read More

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Serum index rules prevent risk of analysing uncentrifuged tubes on automated biochemistry analysers.

Scand J Clin Lab Invest 2021 Aug 4:1-6. Epub 2021 Aug 4.

Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark.

Around 1.5% of the total clinical biochemistry tests performed in laboratories are affected by preanalytical errors. Large, automated chemistry analysers prevent errors and interference by using control systems such as spectrophotometric measurements to evaluate serum indices, i. Read More

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Editorial Comment: Automated CT Perfusion Imaging-Moving Towards a More Nuanced Interpretation.

Gregory Avey

AJR Am J Roentgenol 2021 Aug 4. Epub 2021 Aug 4.

University of Wisconsin School of Medicine and Public Health, Madison, WI.

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Screening for New Pathways in Atmospheric Oxidation Chemistry with Automated Mechanism Generation.

J Phys Chem A 2021 Aug 4. Epub 2021 Aug 4.

Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.

In the Earth's atmosphere, reactive organic carbon undergoes oxidation via a highly complex, multigeneration process, with implications for air quality and climate. Decades of experimental and theoretical studies, primarily on the reactions of hydrocarbons, have led to a canonical understanding of how gas-phase oxidation of organic compounds takes place. Recent research has brought to light a number of examples where the presence of certain functional groups opens up reaction pathways for key radical intermediates, including alkyl radicals, alkoxy radicals, and peroxy radicals, that are substantially different from traditional oxidation mechanisms. Read More

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Synthesis of C-Mannosylated Glycopeptides Enabled by Ni-Catalyzed Photoreductive Cross-Coupling Reactions.

J Am Chem Soc 2021 Aug 4. Epub 2021 Aug 4.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.

The biological functions of tryptophan C-mannosylation are poorly understood, in part, due to a dearth of methods for preparing pure glycopeptides and glycoproteins with this modification. To address this issue, efficient and scalable methods are required for installing this protein modification. Here, we describe unique Ni-catalyzed cross-coupling conditions that utilize photocatalysis or a Hantzsch ester photoreductant to couple glycosyl halides with (hetero)aryl bromides, thereby enabling the α-C-mannosylation of 2-bromo-tryptophan, peptides thereof, and (hetero)aryl bromides more generally. Read More

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A technology of a different sort: microraft arrays.

Lab Chip 2021 Aug 4. Epub 2021 Aug 4.

Department of Bioengineering, University of Washington, Seattle, WA, USA.

A common procedure performed throughout biomedical research is the selection and isolation of biological entities such as organelles, cells and organoids from a mixed population. In this review, we describe the development and application of microraft arrays, an analysis and isolation platform which enables a vast range of criteria and strategies to be used when separating biological entities. The microraft arrays are comprised of elastomeric microwells with detachable polymer bases (microrafts) that act as capture and culture sites as well as supporting carriers during cell isolation. Read More

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Activity detection and classification from wristband accelerometer data collected on people with type 1 diabetes in free-living conditions.

Comput Biol Med 2021 Jul 12;135:104633. Epub 2021 Jul 12.

This paper introduces methods to estimate aspects of physical activity and sedentary behavior from three-axis accelerometer data collected with a wrist-worn device at a sampling rate of 32 [Hz] on adults with type 1 diabetes (T1D) in free-living conditions. In particular, we present two methods able to detect and grade activity based on its intensity and individual fitness as sedentary, mild, moderate or vigorous, and a method that performs activity classification in a supervised learning framework to predict specific user behaviors. Population results for activity level grading show multi-class average accuracy of 99. Read More

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The effects of transport by pneumatic tube system on urine analysis.

Scand J Clin Lab Invest 2021 Aug 4:1-4. Epub 2021 Aug 4.

Biochemistry Department, Ministry of Health Ankara City Hospital, Ankara, Turkey.

The pneumatic tube transport system (PTS) is used frequently for the transport of samples in hospitals. Effects of PTS on urine components are unknown. In our study, we aim to examine the influence of PTS on the quality of routine urine microscopic parameters. Read More

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No pain, just gain: Painless, easy, and fast Dried Blood Spot collection from fingertip and upper arm in doping control.

Drug Test Anal 2021 Aug 3. Epub 2021 Aug 3.

Science and Research, Anti Doping Denmark, Brøndby, Denmark.

This study aimed to determine and compare the perception, painfulness, and usability of the minimally invasive Dried Blood Spot (DBS) collections from fingertip vs. upper arm from different athlete populations: males and females representing sports dependent on hand/arm, sports less dependent on hand/arm and para-athletes. To accomplish this, 108 national level athletes from Denmark were recruited (♀ = 49, ♂ = 59, 25 ± 6 years; mean±SD) and 11 Doping Control Officers (DCOs) collected manual fingerprick DBS (HemaSpot HF) and automated upper-arm DBS (Tasso-M20) from each athlete. Read More

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Automated evaluation of psychotherapy skills using speech and language technologies.

Behav Res Methods 2021 Aug 3. Epub 2021 Aug 3.

Department of Electrical and Computer Engineering, University of Southern California, Los Angeles, California, USA.

With the growing prevalence of psychological interventions, it is vital to have measures which rate the effectiveness of psychological care to assist in training, supervision, and quality assurance of services. Traditionally, quality assessment is addressed by human raters who evaluate recorded sessions along specific dimensions, often codified through constructs relevant to the approach and domain. This is, however, a cost-prohibitive and time-consuming method that leads to poor feasibility and limited use in real-world settings. Read More

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O mouse, where art thou? The Mouse Position Surveillance System (MoPSS)-an RFID-based tracking system.

Behav Res Methods 2021 Aug 3. Epub 2021 Aug 3.

German Center for the Protection of Laboratory Animals (Bf3R), German Federal Institute for Risk Assessment (BfR), Max-Dohrn-Str. 8-10, 10589, Berlin, Germany.

Existing methods for analysis of home cage-based preference tests are either time-consuming, not suitable for group management, expensive, and/or based on proprietary equipment that is not freely available. To correct this, we developed an automated system for group-housed mice based on radio frequency identification: the Mouse Position Surveillance System (MoPSS). The system uses an Arduino microcontroller with compatible components; it is affordable and easy to rebuild for every laboratory because it uses free and open-source software and open-source hardware with the RFID readers as the only proprietary component. Read More

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Comparison of the Results of Manual and Automated Processes of Cross-Mapping Between Nursing Terms: Quantitative Study.

JMIR Nurs 2020 Jan-Dec;3(1):e18501. Epub 2020 Jun 9.

Graduate Program in Health Technology Pontificia Universidade Católica do Paraná Curitiba Brazil.

Background: Cross-mapping establishes equivalence between terms from different terminology systems, which is useful for interoperability, updated terminological versions, and reuse of terms. Due to the number of terms to be mapped, this work can be extensive, tedious, and thorough, and it is susceptible to errors; this can be minimized by automated processes, which use computational tools.

Objective: The aim of this study was to compare the results of manual and automated term mapping processes. Read More

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Retinal vascular findings in patients with COVID-19.

Ther Adv Ophthalmol 2021 Jan-Dec;13:25158414211030419. Epub 2021 Jul 13.

Surgical Oncology Department, Yıldırım Beyazıt University, Ankara, Turkey.

Purpose: The purpose of this study was to compare the retinal vascular caliber of COVID-19 patients with that of healthy subjects.

Methods: This was a prospective case-control study. Forty-six patients who had COVID-19 were successfully treated, and 38 age- and gender-matched healthy subjects were enrolled in this study. Read More

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Improving Compliance with a Rounding Checklist through Low- and High-technology Interventions: A Quality Improvement Initiative.

Pediatr Qual Saf 2021 Jul-Aug;6(4):e437. Epub 2021 Jul 28.

Division of Neonatology, Department of Pediatrics, Children's Hospital of Philadelphia.

Introduction: Checklists aid in ensuring consistency and completeness in medical care delivery. However, using an improvement and safety checklist during rounds was variable in our neonatology intensive care unit (NICU), and completion was not tracked sustainably. This quality improvement (QI) initiative's primary aim was to increase compliance with checklist completion from 31% to >75% within 1 year. Read More

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The potential impact of acute coronary syndromes on automatic sensing system in Subcutaneous-ICDs.

Int J Cardiol Heart Vasc 2021 Aug 20;35:100841. Epub 2021 Jul 20.

Department of Cardiovascular Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli, 8, Roma, Italy.

Background: The Subcutaneous-ICD (S-ICD) is emerging as a suitable option for most ICD candidates, however some open issues regarding the sensing algorithm still remain.

Objectives: We aimed to examine the performance of the S-ICD sensing algorithm in patients hospitalized for ST elevation myocardial infarction (STEMI), non ST elevation acute coronary syndrome (NSTE-ACS) or chronic coronary syndrome (CCS), before and after revascularization.

Methods: We performed a S-ICD automated screening on 75 patients, 21 hospitalized for STEMI, 23 for NSTE-ACS and 31 for CCS, before and after percutaneous revascularization, regardless their eligibility to ICD implantation. Read More

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Development and validation of an automated solid-phase extraction-LC-MS/MS method for the bioanalysis of fluoxetine in human plasma.

J Adv Pharm Technol Res 2021 Jul-Sep;12(3):267-273. Epub 2021 Jul 16.

Department of Clinical Pharmacy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, Riyadh, Saudi Arabia.

A wide-range, specific, and precise liquid chromatography tandem mass spectrometric (LC-MS/MS)technique for quantifying fluoxetine (FLX) in human plasma was developed using the RapidTrace automated solid-phase extraction (SPE) method; the analyte and internal standard (IS) were extricated on Oasis MCX SPE cartridges. Acetonitrile and 5 mM ammonium formate buffer (90:10 v/v) were used as mobile phase to achieve chromatographic separation on the reverse phase (C column). The analyte and IS were ionized using +ve electrospray ionization approach which was further traced by multiple-reaction monitoring on a tandem mass spectrometer. Read More

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Spotlight on the Corneal Back Surface Astigmatism: A Review.

Clin Ophthalmol 2021 26;15:3157-3164. Epub 2021 Jul 26.

Kyiv City Clinical Ophthalmological Hospital "Eye Microsurgical Center", Kyiv, Ukraine.

Recent evidence indicates that the corneal back surface astigmatism (CBSA) contributes to the refractive state of the eye in cataract surgery, especially with the implantation of toric intraocular lenses. But this has been met with some scepticism. A review of key studies performed over the past three decades shows that the mean CBSA power ranges from 0. Read More

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Automated detection of retinal exudates and drusen in ultra-widefield fundus images based on deep learning.

Eye (Lond) 2021 Aug 3. Epub 2021 Aug 3.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Background: Retinal exudates and/or drusen (RED) can be signs of many fundus diseases that can lead to irreversible vision loss. Early detection and treatment of these diseases are critical for improving vision prognosis. However, manual RED screening on a large scale is time-consuming and labour-intensive. Read More

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TrendyGenes, a computational pipeline for the detection of literature trends in academia and drug discovery.

Sci Rep 2021 Aug 3;11(1):15747. Epub 2021 Aug 3.

Exscientia Ltd, Dundee One, River Court, 5 West Victoria Dock Road, Dundee, DD1 3JT, UK.

Target identification and prioritisation are prominent first steps in modern drug discovery. Traditionally, individual scientists have used their expertise to manually interpret scientific literature and prioritise opportunities. However, increasing publication rates and the wider routine coverage of human genes by omic-scale research make it difficult to maintain meaningful overviews from which to identify promising new trends. Read More

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Accuracy of automated machine learning in classifying retinal pathologies from ultra-widefield pseudocolour fundus images.

Br J Ophthalmol 2021 Aug 3. Epub 2021 Aug 3.

Department of Ophthalmology, Hopital Maisonneuve-Rosemont (CUO-HMR), Montreal, Quebec, Canada

Aims: Automated machine learning (AutoML) is a novel tool in artificial intelligence (AI). This study assessed the discriminative performance of AutoML in differentiating retinal vein occlusion (RVO), retinitis pigmentosa (RP) and retinal detachment (RD) from normal fundi using ultra-widefield (UWF) pseudocolour fundus images.

Methods: Two ophthalmologists without coding experience carried out AutoML model design using a publicly available image data set (2137 labelled images). Read More

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Quantification of spatial metal accumulation patterns in Noccaea caerulescens by X-ray fluorescence image processing for genetic studies.

Plant Methods 2021 Aug 3;17(1):86. Epub 2021 Aug 3.

Laboratory of Genetics, Department of Plant Sciences, Wageningen University and Research, Wageningen, The Netherlands.

Background: Hyperaccumulation of trace elements is a rare trait among plants which is being investigated to advance our understanding of the regulation of metal accumulation and applications in phytotechnologies. Noccaea caerulescens (Brassicaceae) is an intensively studied hyperaccumulator model plant capable of attaining extremely high tissue concentrations of zinc and nickel with substantial genetic variation at the population-level. Micro-X-ray Fluorescence spectroscopy (µXRF) mapping is a sensitive high-resolution technique to obtain information of the spatial distribution of the plant metallome in hydrated samples. Read More

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[Descemet membrane endothelial keratoplasty in initial cases: analysis and management of surgical complications].

Zhonghua Yan Ke Za Zhi 2021 Aug;57(8):595-600

Department of Ophthalmology, Peking University Third Hospital, Beijing 100191, China.

To investigate causes and management of surgical complications of Descemet membrane endothelial keratoplasty (DMEK) in initial cases. A retrospective study. A total of 52 eyes of 52 patients underwent DMEK by one surgeon in Peking University Third Hospital from February 2017 to December 2019, including 17 males and 35 females, aged (66±12) years. Read More

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[Acute kidney injury - Update 2021].

Dtsch Med Wochenschr 2021 Aug 3;146(15):988-993. Epub 2021 Aug 3.

Medizinische Klinik mit Schwerpunkt Nephrologie und Internistische Intensivmedizin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin.

One in five hospitalized patients suffers acute kidney injury (AKI). Depending on its severity, AKI is associated with an up to 15-fold increased risk of mortality and constitutes a major risk factor for subsequent cardiovascular events and for the development of chronic kidney disease. This concise review summarizes recently published studies, focusing on 1. Read More

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