2,102 results match your criteria Autoimmunity Reviews [Journal]


Autosomic dominant familial Behçet disease and haploinsufficiency A20: A review of the literature.

Autoimmun Rev 2018 Jun 8. Epub 2018 Jun 8.

Département de médecine interne et pneumologie, CHU de Brest, Hôpital La Cavale Blanche, Brest Cedex, France; EA 3878, GETBO, Université Bretagne Loire, Brest Cedex, France. Electronic address:

Introduction: Behçet disease (BD) is a systemic vasculitis involving vessels from any size with various clinical features. Most BD cases are multifactorial and associated with the HLA B51 antigen. In rare and severe early onset cases, dominant Mendelian transmission has been linked to mutations in the TNFAIP3 gene encoding A20. Read More

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Endoplasmic reticulum stress in autoimmune diseases: Can altered protein quality control and/or unfolded protein response contribute to autoimmunity? A critical review on Sjögren's syndrome.

Autoimmun Rev 2018 Jun 8. Epub 2018 Jun 8.

Programa de Biología Celular y Molecular, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago, Chile. Electronic address:

For many years, researchers in the field of autoimmunity have focused on the role of the immune components in the etiopathogenesis of autoimmune diseases. However, some studies have demonstrated the importance of target tissues in their pathogenesis and the breach of immune tolerance. The immune system as well as target tissue cells (plasmatic, β-pancreatic, fibroblast-like synoviocytes, thyroid follicular and epithelial cells of the lachrymal glands, salivary glands, intestine, bronchioles and renal tubules) share the characteristic of secretory cells with an extended endoplasmic reticulum (ER). Read More

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June 2018
2 Reads

Symptomatic polyautoimmunity at diagnosis of 1463 childhood-onset lupus: A Brazilian multicenter study.

Autoimmun Rev 2018 Jun 7. Epub 2018 Jun 7.

Pediatric Rheumatology Unit, Children's Institute, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil; Division of Rheumatology Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. Electronic address:

Objective: To evaluate symptomatic polyautoimmunity (PA) at childhood-onset systemic lupus erythematosus(cSLE) diagnosis, and its association with demographic data, disease activity, clinical manifestations and laboratorial abnormalities in a large Brazilian cSLE population.

Methods: A multicenter retrospective study was performed in 1463 cSLE(ACR criteria) patients from 27 Pediatric Rheumatology services. Symptomatic PA was defined according to the presence of more than one concomitant autoimmune disease(AD) and symptomatic multiple autoimmune syndrome(MAS) was defined as three or more AD. Read More

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June 2018
2 Reads

The use of interleukin 1 receptor antagonist (anakinra) in Kawasaki disease: A retrospective cases series.

Autoimmun Rev 2018 Jun 6. Epub 2018 Jun 6.

Université Paris Sud-Saclay, UVSQ, Le Kremlin Bicêtre, France; AP-HP, CHU de Bicêtre, Pediatric Rheumatology, CEREMAIA, Le Kremlin Bicêtre, France.

Objectives: To identify the clinical characteristics, reasons for use and response to treatment with anakinra in a series of patients with Kawasaki Disease (KD).

Study Design: A retrospective chart review of patients treated with anakinra for KD diagnosed according to the AHA criteria. We compared clinical, biological and echocardiographic characteristics of KD before and after anakinra use. Read More

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The 2018 pipeline of targeted therapies under clinical development for Systemic Lupus Erythematosus: a systematic review of trials.

Autoimmun Rev 2018 Jun 6. Epub 2018 Jun 6.

Service de Rhumatologie, Hôpitaux Universitaires de Strasbourg, INSERM UMR_S1109, RESO, Université de Strasbourg, F-67000 Strasbourg, France. Electronic address:

Currently, Systemic Lupus Erythematosus (SLE) therapies range from antimalarials to glucocorticoids, in addition to immunosupressive agents or biologics such as rituximab or belimumab, when needed. Several unmet needs remain in the treatment SLE and more targeted drugs with improved safety profiles are expected. Based on recent advances in the understanding of the complex pathogenesis of SLE, several targeted treatments are currently assessed in clinical trials. Read More

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June 2018
3 Reads

Polyautoimmunity: Risk factors for a unique clinical entity.

Authors:
Oded Shamriz

Autoimmun Rev 2018 Jun 6. Epub 2018 Jun 6.

Pediatric Division, Hadassah-Hebrew University Medical Center, Ein-Kerem, Jerusalem, Israel. Electronic address:

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June 2018
1 Read

Antiphospholipid antibodies in epilepsy: A systematic review and meta-analysis.

Autoimmun Rev 2018 Jun 6. Epub 2018 Jun 6.

School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, 47500 Bandar Sunway, Selangor, Malaysia.

Background: Autoimmunity is believed to play an important causative role in the pathogenesis of epilepsy. There are evidences for the presence of autoantibodies in patients with epilepsy. To date, many studies have assessed the presence of antiphospholipid antibodies (aPLs) in epilepsy patients, though the relationship has been inconclusive. Read More

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Primary antiphospholipid syndrome and antiphospholipid syndrome associated to systemic lupus: Are they different entities?

Autoimmun Rev 2018 Jun 6. Epub 2018 Jun 6.

Coagulation Laboratory, Department of Clinical Biology, Immunology and Microbiology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium.

Primary antiphospholipid syndrome (PAPS) and antiphospholipid syndrome associated to lupus (SAPS) have several overlapping characteristics. As systemic manifestations are also reported in patients with PAPS, and as a subgroup of PAPS patients could evaluate to a SAPS, the differentiation between the two types of APS could be performed based on the clinical experience of the medical teams and is related to a variety of clinical, biological, histological and genetic features. Several data are available in the literature with respect to the identification of distinctive features between these two entities. Read More

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Is laser speckle contrast analysis (LASCA) the new kid on the block in systemic sclerosis? A systematic literature review and pilot study to evaluate reliability of LASCA to measure peripheral blood perfusion in scleroderma patients.

Autoimmun Rev 2018 Jun 6. Epub 2018 Jun 6.

Department of Rheumatology, Ghent University Hospital, Department of Internal Medicine, Ghent University, Corneel Heymanslaan 10, Ghent, Belgium. Electronic address:

Objectives: A reliable tool to evaluate flow is paramount in systemic sclerosis (SSc). We describe herein on the one hand a systematic literature review on the reliability of laser speckle contrast analysis (LASCA) to measure the peripheral blood perfusion (PBP) in SSc and perform an additional pilot study, investigating the intra- and inter-rater reliability of LASCA.

Methods: A systematic search was performed in 3 electronic databases, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Read More

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Intravenous Immunoglobulins as a new opportunity to treat discoid lupus erythematosus: A case report and review of the literature.

Autoimmun Rev 2018 Jun 6. Epub 2018 Jun 6.

Rheumatology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Italy. Electronic address:

Discoid lupus erythematosus (DLE) is a chronic dermatological disease that can lead to scarring, alopecia and dyspigmentation, if not properly treated. Actually, no drugs are specifically approved for the treatment of CLE, although the first-line therapy usually consists of photoprotection associated to topical or oral steroids, topical calcineurin inhibitors and hydroxychloroquine (HCQ). In cases of DLE refractory to these medications, many other agents have been employed, such as dapsone, methotrexate, azathioprine, cyclophosphamide, biologic drugs and Intravenous Immunoglobulin (IVIG). Read More

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Immune checkpoint failures in inflammatory myopathies: An overview.

Autoimmun Rev 2018 Jun 6. Epub 2018 Jun 6.

Department of Neurology, Ghent University and Ghent University Hospital, C. Heymanslaan 10, 9000 Gent, Belgium.

Dermatomyositis (DM), polymyositis (PM), inclusion bosy myositis (IBM), immune mediated necrotizing myopathy (IMNM) and overlap myositis (OM) are classified as inflammatory myopathies (IM) with involvement of autoimmune features such as autoreactive lymphocytes and autoantibodies. Autoimmunity can be defined as a loss in self-tolerance and attack of autoantigens by the immune system. Self-tolerance is achieved by a group of immune mechanisms occurring in central and periphal lymphoid organs and tissues, called immune checkpoints, that work in synergy to protect the body from harmful immune reactions. Read More

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Impact of obesity on autoimmune arthritis and its cardiovascular complications.

Autoimmun Rev 2018 Jun 6. Epub 2018 Jun 6.

Jesse Brown VA Medical Center, Chicago, IL 60612, United States; Department of Medicine, Division of Rheumatology, University of Illinois at Chicago, IL 60612, United States. Electronic address:

Obesity can instigate and sustain a systemic low-grade inflammatory environment that can amplify autoimmune disorders and their associated comorbidities. Metabolic changes and inflammatory factors produced by the adipose tissue have been reported to aggravate autoimmunity and predispose the patient to cardiovascular disease (CVD) and metabolic comorbidities. Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) are autoimmune arthritic diseases, often linked with altered body mass index (BMI). Read More

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June 2018
2 Reads

Predictors of morbidity and mortality in early systemic sclerosis: Long-term follow-up data from a single-centre inception cohort.

Autoimmun Rev 2018 Jun 6. Epub 2018 Jun 6.

First Department of Propaedeutic and Internal Medicine and Joint Academic Rheumatology Program, National and Kapodistrian University, Medical School of Athens, Greece. Electronic address:

Objectives: To determine predictors of morbidity and mortality in systemic sclerosis (SSc) in a long-term follow-up of an inception cohort of early SSc patients.

Methods: We evaluated clinical manifestations, laboratory and lung function tests at disease onset as predictors of morbidity and mortality in 3rd, 6th and 9th year in SSc patients recruited within 12 months of disease onset.

Results: A total of 115 SSc patients (97 women, mean age 48. Read More

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Inflammation and atherosclerosis: Cardiovascular evaluation in patients with autoimmune diseases.

Autoimmun Rev 2018 May 3. Epub 2018 May 3.

Department of Autoimmune Diseases, Institut Clínic de Medicina i Dermatologia, Hospital Clínic, IDIBAPS, University of Barcelona, Barcelona, Catalonia, Spain. Electronic address:

Evidence now indicates that inflammation contributes considerably to the initiation and progression of atherosclerosis and active inflammatory processes may trigger plaque rupture and enhance the risk of coronary thrombosis leading to a clinical ischemic event. Interest in characterizing inflammatory markers that predict clinical events have dominated clinical investigation. Such markers include C-reactive protein, Fibrinogen and a number of interleukins. Read More

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Mortality in systemic necrotizing vasculitides: A retrospective analysis of the French Vasculitis Study Group registry.

Autoimmun Rev 2018 May 3. Epub 2018 May 3.

National Referral Centre for rare Juvenile Rheumatological and Autoimmune Diseases, Department of Internal and Vascular Medicine, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, CNRS, Claude Bernard University Lyon 1, Lyon, France. Electronic address:

Objective: The aim of the study was to describe the evolution of mortality and cause-specific mortality over time in patients with systemic necrotizing vasculitides (SNV), including polyarteritis nodosa (PAN), granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA).

Methods: Patients with SNV from the French Vasculitis Study Group registry were divided into 5 groups according to the date of diagnosis: <1980, 1980-1989, 1990-1999, 2000-2010, and ≥ 2010. The causes of death were classified as vasculitis, infection, cardiovascular, malignancy, miscellaneous, or unknown. Read More

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May 2018
3 Reads

The SLAM family receptors: Potential therapeutic targets for inflammatory and autoimmune diseases.

Autoimmun Rev 2018 May 3. Epub 2018 May 3.

Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY 10016, USA; Perlmutter Cancer Center, NYU School of Medicine, New York, NY 10016, USA. Electronic address:

The signaling lymphocytic activation molecule (SLAM) family is comprised of nine distinct receptors (SLAMF1 through SLAMF9) that are expressed on hematopoietic cells. All of these receptors, with the exception of SLAMF4, are homotypic by nature as downstream signaling occurs when hematopoietic cells that express the same SLAM receptor interact. The SLAM family receptor function is largely controlled via SLAM associated protein (SAP) family adaptors. Read More

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Cytokine markers of B lymphocytes in minor salivary gland infiltrates in Sjögren's syndrome.

Autoimmun Rev 2018 May 3. Epub 2018 May 3.

GIRAT: Grupo de Investigación en Reumatología, Inmunología y Medicina Traslacional, Fundación, Valle del Lili, Universidad Icesi, School of Medicine Cali, Colombia; Department of Internal Medicine, Universidad Icesi, Cali, Colombia; Universidad Icesi, Medical School, Cali, Colombia; Laboratory of Immunology, Fundación Valle Del Lili. Cra. 98 18-49, Cali, Colombia. Electronic address:

Sjögren's syndrome (SS) is a chronic autoimmune disorder characterised by the clinical presence of sicca syndrome. SS compromises the dysfunction of exocrine glands due to the presence of focal, mononuclear cell infiltrates that surround the ducts and replace the secretory units. Abnormal expression of different cytokines and chemokines such as B-cell activating factor, CXC Motif Chemokine Ligand 13, interleukin 6 (IL-6), IL-22, and FMS-like tyrosine kinase 3 ligand as well as that of their corresponding receptors has been implicated in the inflammatory process. Read More

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Disease course and long-term outcome of juvenile localized scleroderma: Experience from a single pediatric rheumatology Centre and literature review.

Autoimmun Rev 2018 May 3. Epub 2018 May 3.

Pediatric Rheumatology Unit, Department of Woman and Child Health, University of Padova, Italy.

Juvenile Localized Scleroderma (JLS) is a rare disorder that may cause severe aesthetic sequelae and functional disability. To date, data on natural history and long-term outcome are discordant and difficult to compare due to the heterogeneity of clinical subtypes, treatments and methods to evaluate activity and outcome in previous studies. A retrospective and cross-sectional study including 133 patients followed between January 1991 and December 2016 was conducted at our Pediatric Rheumatology Centre. Read More

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May 2018
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New use for an old treatment: Hydroxychloroquine as a potential treatment for systemic vasculitis.

Autoimmun Rev 2018 May 2. Epub 2018 May 2.

Louise Coote Lupus Unit, Guy's Hospital, Great Maze Pond, London SE1 9RT, United Kingdom. Electronic address:

Antimalarials have been an effective and safe treatment for autoimmune rheumatic diseases such as systemic lupus erythematosus for more than a hundred years. There are surprisingly few reports of hydroxychloroquine use in the systemic vasculitides. Hydroxychloroquine has antithrombotic, cardiovascular, antimicrobial and antineoplastic effects, making it a potentially valuable treatment for patients with systemic vasculitis who are at risk of infections, malignancy and thrombotic events. Read More

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May 2018
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NLRP3: A promising therapeutic target for autoimmune diseases.

Autoimmun Rev 2018 May 3. Epub 2018 May 3.

Department of Epidemiology & Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, 81 Meishan Road, Hefei, Anhui, China. Electronic address:

NLRP3, a member of nucleotide-binding domain-(NOD) like receptor family, can be found in large varieties of immune and non-immune cells. Upon activation, the NLRP3, apoptosis-associated speck-like protein (ASC) and pro-caspase-1 would assemble into a multimeric protein, called the NLRP3 inflammasome. Then the inflammasome promotes inflammation (through specific cleavage and production of bioactive IL-1β and IL-18) and pyroptotic cell death. Read More

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Quality of life and neuropsychiatric disorders in patients with Graves' Orbitopathy: Current concepts.

Autoimmun Rev 2018 May 2. Epub 2018 May 2.

Department of Sense Organs, University Sapienza of Rome, Viale del Policlinico 155, 00161 Rome, Italy. Electronic address:

Graves' disease (GD) is an autoimmune chronic thyroiditis frequently associated with development of Graves' orbitopathy (GO) characterized by proptosis, strabismus, impairment of visual function, ocular surface inflammation and dry eye. As consequence, patients with GO experience impairment of quality of life and social function and could develop a neurobehavioral syndrome, ranging from anxious to depressive or psychotic disorders. To date, the pathogenic mechanism underlying neuropsychiatric disorders in patients with GD has not been clearly understood. Read More

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Hearing loss in autoimmune disorders: Prevalence and therapeutic options.

Autoimmun Rev 2018 May 3. Epub 2018 May 3.

Department of Sense Organs, Sapienza University of Rome, Viale del Policlinico 155, 00100 Rome, Italy. Electronic address:

The objective of this study was to review our current knowledge relative to the correlation between sensorineural hearing loss (SNHL) and autoimmune diseases, focusing on the prevalence of hearing loss in different pathologies and possible therapeutic approaches. A review of the literature on hearing loss in different forms of autoimmune disease has been carried out, with emphasis on incidence and prevalence of SNHL. Therapeutic protocols have been assessed including both conservative medical and rehabilitative methods. Read More

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May 2018
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Emerging role of IL-35 in inflammatory autoimmune diseases.

Autoimmun Rev 2018 May 3. Epub 2018 May 3.

Department of Evidence-Based Medicine, School of Public Health, Southwest Medical University, 1 Xianglin Road, Luzhou, Sichuan 646000, PR China. Electronic address:

Interleukin 35 (IL-35) is the recently identified member of the IL-12 family of cytokines and provides the possibility to be a target for new therapies for autoimmune, inflammatory diseases. It is composed of an α chain (p35) and a β chain (EBI3). IL-35 mediates signaling by binding to its receptors, activates subsequent signaling pathways, and therefore, regulates the differentiation, function of T, B cells, macrophages, dendritic cells. Read More

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Non-glucocorticoid drugs for the treatment of Takayasu's arteritis: A systematic review and meta-analysis.

Autoimmun Rev 2018 May 2. Epub 2018 May 2.

Vasculitis Clinic, Division of Rheumatology, Mount. Sinai Hospital, University of Toronto, Toronto, Canada.

Background: Takayasu's Arteritis (TAK) affects mostly young women and causes significant morbidity. Most patients are refractory to glucocorticoids (GC) or relapse when GC doses are reduced. The objective of this study is to summarize the literature pertaining to the effectiveness of non-GC drugs for the treatment of TAK. Read More

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May 2018
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Positron emission tomography (PET) and single photon emission computed tomography (SPECT) imaging of macrophages in large vessel vasculitis: Current status and future prospects.

Autoimmun Rev 2018 May 3. Epub 2018 May 3.

Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address:

Macrophages are key players in the pathogenesis of large-vessel vasculitis (LVV) and may serve as a target for diagnostic imaging of LVV. The radiotracer, F-FDG has proven to be useful in the diagnosis of giant cell arteritis (GCA), a form of LVV. Although uptake of F-FDG is high in activated macrophages, it is not a specific radiotracer as its uptake is high in any proliferating cell and other activated immune cells resulting in high non-specific background radioactivity especially in aging and atherosclerotic vessels which dramatically lowers the diagnostic accuracy. Read More

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May 2018
1 Read

Analysis of microRNA expression in the thymus of Myasthenia Gravis patients opens new research avenues.

Autoimmun Rev 2018 Jun 13;17(6):588-600. Epub 2018 Apr 13.

Sorbonne Université, INSERM, Association Institut de Myologie, Center of Research in Myology, UMRS 974, Paris, France. Electronic address:

In early-onset Myasthenia Gravis (MG) with anti-acetylcholine receptor antibodies, thymic abnormalities associated with ectopic germinal centers are frequent. miRNAs by acting as post-transcriptional regulators are involved in autoimmunity. To investigate the implication of miRNAs in thymic changes associated with early-onset MG, we performed a miRnome study and data were analyzed with different approaches. Read More

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June 2018
3 Reads

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - Evidence for an autoimmune disease.

Autoimmun Rev 2018 Jun 7;17(6):601-609. Epub 2018 Apr 7.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Institute of Medical Immunology, Augustenburger Platz 1, 13353 Berlin, Germany. Electronic address:

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a frequent and severe chronic disease drastically impairing life quality. The underlying pathomechanism is incompletely understood yet but there is convincing evidence that in at least a subset of patients ME/CFS has an autoimmune etiology. In this review, we will discuss current autoimmune aspects for ME/CFS. Read More

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June 2018
1 Read

Efficacy and safety of rituximab in systemic sclerosis: French retrospective study and literature review.

Autoimmun Rev 2018 Jun 7;17(6):582-587. Epub 2018 Apr 7.

Department of Internal Medicine, Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Assistance Publique - Hôpitaux de Paris, Hôpital Saint-Antoine, 184, rue du Faubourg Saint-Antoine, 75012 Paris, France; Sorbonne Universités, UMPC University Paris 06, INSERM U938, Centre de Recherche Saint-Antoine (CRSA), Paris, France. Electronic address:

Objective: To describe safety and efficacy of rituximab in patients with systemic sclerosis.

Methods: We included 13 patients with systemic sclerosis treated with rituximab and pooled with 40 additional patients from the literature. SSc rituximab untreated patients were matched to rituximab treated ones. Read More

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June 2018
1 Read

Antinuclear antibodies: Is the indirect immunofluorescence still the gold standard or should be replaced by solid phase assays?

Autoimmun Rev 2018 Jun 7;17(6):548-552. Epub 2018 Apr 7.

Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel; Laboratory of the Mosaic of Autoimmunity, Department of Pathology, Faculty of Medicine, Saint Petersburg State University, Russia; Sackler Faculty of Medicine, Tel-Aviv University, Israel; Incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases, Sackler Faculty of Medicine, Tel-Aviv University, Israel. Electronic address:

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June 2018
2 Reads

Genetic variation and systemic lupus erythematosus: A field synopsis and systematic meta-analysis.

Autoimmun Rev 2018 Jun 7;17(6):553-566. Epub 2018 Apr 7.

Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea; Department of Pediatric Nephrology, Severance Children's Hospital, Seoul, Republic of Korea; Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address:

Systemic lupus erythematosus (SLE) is a multi-systemic severe autoimmune disease which results from the irreversible loss of self-tolerance and impaired molecular responses, especially an altered interferon signature. We synthesized all meta-analyses reporting a genetic association of SLE, and further investigated their validity to discover false positive results under Bayesian methods. We executed a PubMed search to extract the respective results regarding gene polymorphisms of SLE, published until June 30th 2017 and selected a single result per genetic variant among duplicates. Read More

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June 2018
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Systemic lupus erythematosus and systemic sclerosis: All roads lead to platelets.

Autoimmun Rev 2018 Jun 7;17(6):625-635. Epub 2018 Apr 7.

Laboratoire d'Immunologie et Immunogénétique, FHU ACRONIM, Hôpital Pellegrin, Centre Hospitalier Universitaire, Place Amélie Raba Léon, 33076 Bordeaux, France; Université de Bordeaux, 146 rue Léo Saignat, 33076 Bordeaux, France; CNRS-UMR 5164, ImmunoConcept, Université de Bordeaux, 146 rue Léo Saignat, 33076 Bordeaux, France. Electronic address:

Systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) are two phenotypically distincts inflammatory systemic diseases. However, SLE and SSc share pathogenic features such as interferon signature, loss of tolerance against self-nuclear antigens and increased tissue damage such as fibrosis. Recently, platelets have emerged as a major actor in immunity including auto-immune diseases. Read More

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June 2018
2 Reads

The role of ophthalmic imaging in central nervous system degeneration in systemic lupus erythematosus.

Autoimmun Rev 2018 Jun 7;17(6):617-624. Epub 2018 Apr 7.

NOVA Medical School, Universidade NOVA de Lisboa, Lisbon, Portugal; Autoimmune Disease Unit, Unidade de Doenças Auto-imunes/Serviço de Medicina 7.2, Hospital Curry Cabral, Centro Hospitalar de Lisboa Central, Lisbon, Portugal; Instituto Gulbenkian de Ciência, Oeiras, Portugal.

Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disorder that can involve any organ system. Central nervous system involvement can be a severe life threatening complication, ultimately resulting in severe neurodegenerative changes. Magnetic resonance imaging suggests that neurodegeneration, which may have deleterious effects on brain function, may occur early in SLE and experimental models suggest that neuroprotection may be feasible and beneficial. Read More

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June 2018
1 Read

From HSV infection to erythema multiforme through autoimmune crossreactivity.

Authors:
Alberta Lucchese

Autoimmun Rev 2018 Jun 7;17(6):576-581. Epub 2018 Apr 7.

Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania 'Luigi Vanvitelli', Via de Crecchio 6, 80138 Naples, Italy. Electronic address:

Scientific and clinical data indicate that human herpes simplex virus 1 (HSV1) and, at a lesser extent, human herpes simplex virus 2 (HSV2) are factor(s) implicated in the development of erythema multiforme (EM). With a focus on oral EM, the present structured review of proteomic and epitope databases searched for the molecular basis that might link HSV1 and HSV2 infections to EM. It was found that a high number of peptides are shared between the two HSVs and human proteins related to the oral mucosa. Read More

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June 2018
2 Reads

Autoimmune phenomena and disease in cancer patients treated with immune checkpoint inhibitors.

Autoimmun Rev 2018 Jun 7;17(6):610-616. Epub 2018 Apr 7.

Dept. of Internal Medicine C, Wolfson Medical Center, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Israel. Electronic address:

The discovery and approved treatment with immune checkpoint inhibitors (ICIs) for a variety of cancers has changed dramatically the morbidity and mortality rates for these patients. Despite the obvious benefits, their use is associated with unique immune-related adverse effects (irAEs), including autoimmune conditions such as: inflammatory arthritis, myositis, vasculitis and Sicca syndrome. The appearance of ICIs-induced autoimmune irAE requires from oncologists and rheumatologists a different approach to the identification and treatment of these conditions, which may differ from the classic and traditional approach to rheumatologic diseases. Read More

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June 2018
1 Read

Behçet's disease: New insights into pathophysiology, clinical features and treatment options.

Autoimmun Rev 2018 Jun 6;17(6):567-575. Epub 2018 Apr 6.

Department of Sense Organs, Sapienza University of Rome, Viale del Policlinico 155, 00100 Rome, Italy. Electronic address:

Behçet's disease (BD) is a rare systemic vasculitis characterized by oral aphthous ulcers, genital ulcers, ocular lesions and other systemic manifestations. BD occurs most frequently in Eurasian populations along the ancient trading route known as the "Silk Road" which extends from eastern Asia to the Mediterranean basin. The causes of BD are unknown: it is believed to be due to an autoimmune process triggered by an infectious or environmental agent in genetically predisposed individuals. Read More

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June 2018
3 Reads

Validation conform ISO-15189 of assays in the field of autoimmunity: Joint efforts in The Netherlands.

Autoimmun Rev 2018 May 13;17(5):513-517. Epub 2018 Mar 13.

Central Diagnostic Laboratory, Maastricht University Medical Center, P. Debeyelaan 25, 6229 HX Maastricht, The Netherlands. Electronic address:

ISO 15189:2012 requires validation of methods used in the medical laboratory, and lists a series of performance parameters for consideration to include. Although these performance parameters are feasible for clinical chemistry analytes, application in the validation of autoimmunity tests is a challenge. Lack of gold standards or reference methods in combination with the scarcity of well-defined diagnostic samples of patients with rare diseases make validation of new assays difficult. Read More

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May 2018
1 Read

Skeletal muscle cells actively shape (auto)immune responses.

Autoimmun Rev 2018 May 9;17(5):518-529. Epub 2018 Mar 9.

Department of Neurology, University of Münster, Germany. Electronic address:

Histopathological analyses of muscle specimens from myositis patients indicate that skeletal muscle cells play an active role in the interaction with immune cells. Research over the last few decades has shown that skeletal muscle cells exhibit immunobiological properties that perfectly define them as non-professional antigen presenting cells. They are able to present antigens via major histocompatibility complex molecules, exhibit costimulatory molecules and secrete soluble molecules that actively shape the immune response in an either pro- or anti-inflammatory manner. Read More

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May 2018
3 Reads

Clinical and experimental evidence for targeting CD6 in immune-based disorders.

Autoimmun Rev 2018 May 9;17(5):493-503. Epub 2018 Mar 9.

Group of Immunereceptors of the Innate and Adaptive System, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Servei d'Immunologia, Hospital Clínic de Barcelona, Barcelona, Spain; Departament de Biomedicina, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain. Electronic address:

CD6 is a cell surface glycoprotein expressed by most T cells and a subset of B cells that has incompletely-defined roles in regulation of lymphocyte development, selection, activation and differentiation. The two main known mammalian CD6 ligands, CD166/ALCAM and the very recently reported CD318, are widely expressed by both immune cells and a wide range of other cell types, including various epithelial and mesenchymal cell types, as well as many neoplasms. Moreover, CD6 is also a receptor for several pathogen- and damage-associated molecular patterns. Read More

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May 2018
1 Read

Optimizing conventional DMARD therapy for Sjögren's syndrome.

Autoimmun Rev 2018 May 9;17(5):480-492. Epub 2018 Mar 9.

Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands; Laboratory of Translational Immunology, University Medical Centre Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands. Electronic address:

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May 2018
1 Read

Perspective: Scientific and ethical concerns pertaining to animal models of autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA).

Autoimmun Rev 2018 May 8;17(5):435-439. Epub 2018 Mar 8.

Victorian Cytology Service, Carlton, Australia; Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Australia.

The autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA) was first described in 2011. The aluminium containing adjuvants of vaccines were stated to be one of the main causes of the condition. Other disorders associated with ASIA include siliconosis, Gulf war syndrome, sick building syndrome and the macrophagic myositis syndrome. Read More

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May 2018
2 Reads

Solid phase assays versus automated indirect immunofluorescence for detection of antinuclear antibodies.

Autoimmun Rev 2018 Jun 8;17(6):533-540. Epub 2018 Mar 8.

Laboratory Medicine, University Hospitals Leuven, Belgium; Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium. Electronic address:

Solid phase assays (SPAs) and automated microscope systems are increasingly used to screen for antinuclear antibodies (ANAs). The goal of this study was to evaluate the performance of three automated ANA screening assays; NOVA Lite HEp-2 using NOVA View® (NV, Inova Diagnostics), an automated indirect immunofluorescence method, EliA™ CTD Screen (Fluorescence Enzyme Immunoassay, FEIA; Thermo Fisher) and QUANTA Flash® CTD Screen Plus (Chemiluminescence immunoassay, CIA; Inova Diagnostics). The assays were performed on 480 diagnostic samples from patients with an ANA-associated rheumatic disease (AARD; systemic lupus erythematosus, primary Sjögren's syndrome, systemic sclerosis, inflammatory myopathy, mixed connective tissue disease) and on 767 samples from diseased and healthy controls. Read More

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June 2018
2 Reads

Association between allelic variants of the human glucocorticoid receptor gene and autoimmune diseases: A systematic review and meta-analysis.

Autoimmun Rev 2018 May 8;17(5):449-456. Epub 2018 Mar 8.

Department of Medicine, University of Salamanca, Salamanca, Spain; Department of Internal Medicine, University Hospital of Salamanca-SACYL, Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain.

Introduction: The human glucocorticoid receptor gene (NR3C1) is considered to play a role in the differences and sensitivities of the glucocorticoid response in individuals with autoimmune diseases. The objective of this study was to examine by means of a systematic review previous findings regarding allelic variants of NR3C1 in relation to the risk of developing systemic autoimmune diseases.

Methods: Studies that analysed the genotype distribution of NR3C1 allelic variants among patients with systemic autoimmune diseases were retrieved. Read More

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May 2018
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Contribution of sex steroids and prolactin to the modulation of T and B cells during autoimmunity.

Autoimmun Rev 2018 May 9;17(5):504-512. Epub 2018 Mar 9.

Instituto de Medicina y Biología Experimental de Cuyo IMBECU-CCT-CONICET Mendoza, Argentina; Instituto de Fisiología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Argentina; Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile. Electronic address:

In this review we discuss how sex steroids and prolactin affect regulation and responsiveness of B and T cells. Sex hormones exert profound effects on several physiological processes of non- reproductive tissues. In the immune system, several studies with experimental models for SLE have shown a noticeable pro-inflammatory role for ERα, contributing to disease development reflected in proteinuria and renal pathology. Read More

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May 2018
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A methodological review of induced animal models of autoimmune diseases.

Autoimmun Rev 2018 May 8;17(5):473-479. Epub 2018 Mar 8.

Research Center Borstel, Airway Research Center North (ARCN), Members of the German Center for Lung Research (DZL), 23845 Borstel, Germany.

Autoimmune disorders are characterized by a loss of immune tolerance and consequent autoimmunity-mediated disease manifestation. Experimental models are invaluable research tools helping us to understand disease pathogenesis and to search for novel therapeutics. Animal models of autoimmune diseases consist of two groups, spontaneous and induced models. Read More

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May 2018
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The value of Autoimmune Syndrome Induced by Adjuvant (ASIA) - Shedding light on orphan diseases in autoimmunity.

Autoimmun Rev 2018 May 9;17(5):440-448. Epub 2018 Mar 9.

Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Affiliated with the Sackler Faculty of Medicine, Tel-Aviv University, Israel; Department of Internal Medicine 'B', The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel, Sackler Faculty of Medicine, Tel-Aviv University, Israel.

Autoimmune Syndrome Induced by Adjuvant (ASIA) is a definition aimed to describe the common etiological process at the root of five clinical entities sharing similar symptomatology: macrophagic myofasciitis syndrome (MMF), Gulf War Syndrome (GWS), sick building syndrome (SBS), siliconosis, and post vaccination autoimmune phenomena. ASIA illustrates the role of environmental immune stimulating agents, or adjuvants, in the instigation of complex autoimmune reactions among individuals bearing a genetic preponderance for autoimmunity. The value of ASIA lies first in the acknowledgment it provides for patients suffering from these as yet ill-defined medical conditions. Read More

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May 2018
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Letter to the Editor: Autoimmune pathogenic mechanisms in Amyotrophic Lateral Sclerosis.

Autoimmun Rev 2018 May 8;17(5):530-531. Epub 2018 Mar 8.

Department Organs of Sense, ENT Section, 'Sapienza' University of Rome, Viale del Policlinico 155, 00100 Roma, Italy.

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May 2018
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