Search our Database of Scientific Publications and Authors

I’m looking for a

    1988 results match your criteria Autoimmunity Reviews [Journal]

    1 OF 40

    Clinical and pathological significance of cutaneous manifestations in ANCA-associated vasculitides.
    Autoimmun Rev 2017 Sep 14. Epub 2017 Sep 14.
    Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France; Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Paris, France. Electronic address:
    Objectives: Cutaneous manifestations (CM) in ANCA-associated vasculitides (AAV) are frequent, but data on clinical significance and clinical-pathological correlations are lacking.

    Methods: We conducted a multicenter, retrospective study including 1553 AAV patients. Clinical, biological and pathological features have been analyzed, and tissue samples from 46 biopsies were reviewed in a blind manner. Read More

    Primary thromboprophylaxis with low-dose aspirin and antiphospholipid antibodies: Pro's and Con's.
    Autoimmun Rev 2017 Sep 11. Epub 2017 Sep 11.
    Department of Cardiac Thoracic and Vascular Sciences, Clinical Cardiology, Thrombosis Centre, University of Padova, Padova, Italy.
    Whether primary prophylaxis should be prescribed in individuals with antiphospholipid antibodies (aPL) remains controversial due to the lack of relevant evidence-based data. Indeed, it is unclear whether the benefit of LDA outweighs the risk of major bleeding associated LDA in a low-risk population. On the contrary, stratification of aPL-positive subjects according to their aPL profile (combination, isotype and titer), presence of other concomitant risk factors for thrombosis and coexistence of an underling autoimmune disease is essential to decide whether primary prophylactic therapy should be prescribed. Read More

    Aortitis in giant cell arteritis: diagnosis with FDG PET/CT and agreement with CT angiography.
    Autoimmun Rev 2017 Sep 11. Epub 2017 Sep 11.
    Department of Nuclear Medicine, Hôpital Avicenne, Université Paris 13, Assistance Publique - Hôpitaux de Paris, Bobigny, France. Electronic address:
    Objectives: To assess the detection rate of aortitis in giant cell arteritis (GCA) with fluorodeoxyglucose positron emission tomography/computed tomography (PET) and to compare the findings with CT angiography (CTA).

    Methods: Fifty-two GCA patients and 27 controls were included. GCA patients had a PET scan at diagnosis (35/52) or during relapse (17/52). Read More

    Can we withdraw anticoagulation in patients with antiphospholipid syndrome after seroconvertion?
    Autoimmun Rev 2017 Sep 9. Epub 2017 Sep 9.
    Louise Coote Lupus Unit, Guy's and St Thomas' NHS Foundation Trust, London, UK.
    The current mainstay of treatment in patients with thrombotic antiphospholipid syndrome (APS) is long-term anticoagulation, mainly with Vitamin K antagonist agents. Some recently available studies have created new ground for discussion about the possible discontinuation of anticoagulation therapy in patients with a history of thrombotic APS in whom antiphospholipid antibodies (aPL) are not detected any longer (i.e. Read More

    Humanistic and cost burden of systemic sclerosis: A review of the literature.
    Autoimmun Rev 2017 Sep 9. Epub 2017 Sep 9.
    Boehringer Ingelheim GmbH, Ingelheim, Germany. Electronic address:
    Background: Systemic sclerosis (SSc), or systemic scleroderma, is a chronic multisystem autoimmune disease characterised by widespread vascular injury and progressive fibrosis of the skin and internal organs. Patients with SSc have decreased survival, with pulmonary involvement as the main cause of death. Current treatments for SSc manage a range of symptoms but not the cause of the disease. Read More

    The new targeted therapy in systemic lupus erythematosus: Is the glass half-full or half-empty?
    Autoimmun Rev 2017 Sep 9. Epub 2017 Sep 9.
    Policlinic and Hiller Research Unit for Rheumatology, UKD, Heinrich-Heine-University Duesseldorf, Germany.
    Biologic therapy is still limited in lupus, where chronic steroid exposure and wide-spectrum immunosuppression are major triggers of organ damage. In this viewpoint, the authors summarize their views for a "half-full or half-empty" glass on targeted therapy in SLE. The are several reasons for seeing the glass half-empty and in this section the authors propose a critical reflection on scarceness of novel targeted lupus therapies. Read More

    Is PET/CT essential in the diagnosis and follow-up of temporal arteritis?
    Autoimmun Rev 2017 Sep 9. Epub 2017 Sep 9.
    Department of Clinical and Experimental Medicine, University Hospital Gasthuisberg, Leuven, Flanders, Belgium.
    The increasing availability and improvement of imaging techniques are deeply influencing diagnosis and work-up of patients affected with vasculitis, particularly those with large vessel vasculitis (LVV). Fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET), especially when integrated with computed tomography (CT), is taking hold as a useful diagnostic technique to examine the aorta and the other large vessels in giant cell arteritis (GCA) with concomitant large vessel involvement (LV-GCA). In this paper we examined the progresses performed in this field in the last twenty years and the evidence available so far according to two different points of view ('pros' and 'cons'), in order to give a comprehensive answer to a still open question about the role of PET/CT in the diagnosis and follow-up of GCA. Read More

    Bone mineral density and vitamin D status in systemic lupus erythematosus (SLE): A systematic review.
    Autoimmun Rev 2017 Sep 9. Epub 2017 Sep 9.
    Hospital del Mar/Parc de Salut-Mar/IMIM.Barcelona. Electronic address:
    Despite the improvement in the quality of life of patients with SLE due to scientific and technological advances, SLE remains a disease that over the years may produce irreversible damage to patients. Osteoporosis and secondary bone fractures are two of the major causes of irreparable injury in patients with SLE. Vitamin D insufficiency may play a vital role both in reduced Bone Mineral Density (BMD) and in the appearance of fractures, although its mechanisms of action are still unclear. Read More

    Neutrophil extracellular traps (NETs) in autoimmune diseases: A comprehensive review.
    Autoimmun Rev 2017 Sep 9. Epub 2017 Sep 9.
    Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea; Department of Pediatric Nephrology, Severance Children's Hospital, Seoul, Republic of Korea. Electronic address:
    The structures named neutrophil extracellular traps (NETs) are fibrous networks which protrude from the membrane of activated neutrophils. NETs are found in a variety of conditions, such as infection, malignancy, atherosclerosis, and autoimmune diseases such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV), psoriasis, and gout. The impact of NETs on the development mechanisms of autoimmune diseases are proposed to arise from an imbalance between "NETosis" which is a process of NET formation and NET degradation. Read More

    Is ACPA positivity the main driver for rheumatoid arthritis treatment? Pros and cons.
    Autoimmun Rev 2017 Sep 9. Epub 2017 Sep 9.
    Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. Electronic address:
    Rheumatoid Arthritis (RA) is an autoimmune chronic disease that is characterized by the positivity of various antibodies, the most specific being autoantibodies against citrullinated antigens (ACPA). Despite ACPA are not arthritogenic by themselves, ACPA positive individuals have high risk of RA development and ACPA positivity is associated with severe erosive phenotype and higher mortality rate compared to seronegative RA. Moreover, ACPA status is associated with favorable response to biologics targeting pathways involving autoantibody producing cells as B lymphocytes. Read More

    Should we treat congenital heart block with fluorinated corticosteroids?
    Autoimmun Rev 2017 Sep 9. Epub 2017 Sep 9.
    AP-HP, Cochin Hospital, Internal Medicine Department, Centre de référence maladies auto-immunes et systémiques rares, Paris, France; Université Paris Descartes-Sorbonne Paris Cité, Paris, France; INSERM U 1153, Center for Epidemiology and Statistics Sorbonne Paris Cité (CRESS), Paris, France.

    "How I treat" autoimmune diseases: State of the art on the management of rare rheumatic diseases and ANCA-associated systemic idiopathic vasculitis.
    Autoimmun Rev 2017 Oct 2;16(10):995-998. Epub 2017 Aug 2.
    Center of Research of Immunopathology and Rare Diseases - Coordinating Center of the Network for Rare Diseases of Piedmont and Aosta Valley, Department of Clinical and Biological Sciences, and University of Turin, Italy; SCU Nephrology and Dialysis Unit, S. Giovanni Bosco Hospital and University of Turin, Turin, Italy. Electronic address:
    This Special Issue of Autoimmunity Reviews constitutes summaries of presentations at the 20th International Meeting on Immunopathology and Orphan Diseases, held in Torino, Italy, 25-28th January 2017. As such, these presentations represent the state of the art on the pathophysiology of autoimmune diseases as well as the most recent insights into the management of these pathologic conditions. The latter includes both the optimal use of established drugs and approaches as well as novel knowledge on the means and consequences of targeted blocking of molecules or cellular mechanisms. Read More

    Antineutrophil cytoplasmic antibody-associated vasculitides and IgG4-related disease: A new overlap syndrome.
    Autoimmun Rev 2017 Oct 2;16(10):1036-1043. Epub 2017 Aug 2.
    Department of Internal Medicine, National Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France; Université Paris Descartes, Paris 5, Paris, France. Electronic address:
    Objective: Atypical manifestations have been described in patients with ANCA-associated vasculitides (AAV), such as pachymeningitis, orbital mass or chronic periaortitis. Because these manifestations have been associated to the spectrum of IgG4-related disease (IgG4-RD), we hypothesized that both diseases could overlap.

    Methods: We conducted a European retrospective multicenter observational study including patients fulfilling ACR and Chapel Hill criteria for AAV and IgG4-RD Comprehensive Diagnostic Criteria. Read More

    How I treat patients with adult onset Still's disease in clinical practice.
    Autoimmun Rev 2017 Oct 1;16(10):1016-1023. Epub 2017 Aug 1.
    Department of Clinical and Biological Sciences, Center of Research of Immunopathology and Rare Diseases, Coordinating Center of the Network for Rare Diseases of Piedmont and Aosta Valley, S. Giovanni Bosco Hospital and University of Turin, Turin, Italy. Electronic address:
    Adult onset Still's disease (AOSD) is a rare systemic inflammatory disease of unknown etiology characterized by four cardinal signs which are almost always present in patients: high spiking fever, arthralgia (with or without synovitis), maculo-papular salmon-pink evanescent skin rash, striking leukocytosis with neutrophilia. Here, we review the clinical features of AOSD and describe the best practice approaches for its management, reviewing available guidelines and recommendations and providing experts' insights. Read More

    Are cytokines and chemokines suitable biomarkers for Takayasu arteritis?
    Autoimmun Rev 2017 Oct 2;16(10):1071-1078. Epub 2017 Aug 2.
    Rheumatology Division, Universidade Federal de São Paulo - Escola Paulista de Medicina, Rua Botucatu, 740, 3rd Floor, São Paulo, SP zip code: 04032-900, Brazil. Electronic address:
    There is a growing need for disease related biomarkers in Takayasu arteritis (TA).The assessment of pro-inflammatory cytokines and chemokines in TA may provide a better understanding of its pathophysiology, and circulating levels of these mediators may act as biomarkers of disease activity. Serum level of interleukin 6 (IL-6) is a potential biomarker for TA, which is mostly associated with TA status and disease activity. Read More

    How I treat patients with systemic sclerosis in clinical practice.
    Autoimmun Rev 2017 Oct 1;16(10):1024-1028. Epub 2017 Aug 1.
    Rheumatology Unit, University Hospital, Padua, Italy. Electronic address:
    Systemic sclerosis (SSc) or scleroderma is a disorder of the connective tissue affecting the skin, and it is often associated with visceral involvement. The predominant pathological features of SSc are autoimmunity, vasculopathy, and fibrosis. Progressive fibrosis is associated with changes in the microcirculation of the involved organs. Read More

    Using multi-omics methods to understand dermatomyositis/polymyositis.
    Autoimmun Rev 2017 Oct 1;16(10):1044-1048. Epub 2017 Aug 1.
    Department of Rheumatology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, People's Republic of China. Electronic address:
    Idiopathic inflammatory myopathies (IIM) are a group of rare and heterogeneous autoimmune diseases, and the most common subtypes are dermatomyositis (DM) and polymyositis (PM). Despite extensive efforts, the underlying mechanism of IIM remains unclear. Recent efforts to understand the pathogenesis of IIM have included genomics, epigenetics, transcriptomics, proteomics and autoantibody studies. Read More

    The Yin and Yang of regulatory T cell and therapy progress in autoimmune disease.
    Autoimmun Rev 2017 Oct 2;16(10):1058-1070. Epub 2017 Aug 2.
    Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin 541004, China; Department of Immunology, Xiangya School of Medicine, Central South University, Changsha, Hunan 410078, China; Department of Immunology, Faculty of Basic Medicine, Guilin Medical University, Guilin 541004, China. Electronic address:
    Autoimmune diseases (ADs) are primarily mediated by the failure of immunological self-tolerance. Regulatory T cells (Tregs) play a critical role in the maintenance of induced tolerance to peripheral self-antigens, suppressing immoderate immune responses deleterious to the host and preventing the AD development. Tregs and suppressive cytokines are homeostatic with effective cells plus pro-inflammatory cytokines in healthy hosts which is defined as "Yang", and ADs are usually induced in case of disturbed homeostasis, which is defined as "Yin". Read More

    Cancer and autoimmune diseases.
    Autoimmun Rev 2017 Oct 1;16(10):1049-1057. Epub 2017 Aug 1.
    Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel; Sackler Faculty in Medicine, Sheba Medical Center, Tel-Aviv University, Israel.
    Purpose Of Review: The association between autoimmunity and cancer is well established. Cancer has been implicated in some autoimmune disorders (AID), such as scleroderma and myositis. On the other hand, many autoimmune disorders and immunosuppressive therapy, have been linked to an increased risk for cancer. Read More

    Role of anti-receptor autoantibodies in pathophysiology of scleroderma.
    Autoimmun Rev 2017 Oct 1;16(10):1029-1035. Epub 2017 Aug 1.
    Rheumatology Division, Department of Medicine, Georgetown University, United States.
    The pathophysiology of SSc-mediated organ damage is complex and not well understood. Hallmarks of the disease include skin thickening, vasculopathy and gastrointestinal dysmotility. Diverse anti-nuclear antibodies can be used as biomarkers for classification and prognosis, but their role in producing tissue pathology/organ dysfunction is not established. Read More

    Targeting interleukin-6 in autoimmune uveitis.
    Autoimmun Rev 2017 Oct 2;16(10):1079-1089. Epub 2017 Aug 2.
    Uveitis Unit, Institut Clinic d'Oftalmologia, Hospital Clinic de Barcelona, Universitat de Barcelona, Spain.
    Interleukin-6 (IL-6) is a key cytokine that is strongly up-regulated during infection and inflammation. Featuring pleiotropic activity, IL-6 is responsible for the induction of hepatic acute-phase proteins, trafficking of acute and chronic inflammatory cells, differentiation of adaptive T cell responses, homeostatic regulation, and tissue regeneration. Dysregulated IL-6 production has been associated with the development of a wide variety of systemic immune-mediated, chronic diseases, and even certain types of cancer. Read More

    How I treat idiopathic patients with inflammatory myopathies in the clinical practice.
    Autoimmun Rev 2017 Oct 2;16(10):999-1007. Epub 2017 Aug 2.
    Rheumatology Unit, Department of Medicine, University of Padova, Italy.
    Management of patients with idiopathic inflammatory myopathies (IIMs) is challenging given the systemic nature of the disease, which is often complicated by potentially life-threatening manifestations and the lack of standardized treatment regimens. Aim of this review is to provide the currently available evidence for immunotherapy in the treatment of various manifestations of IIM in order to help clinicians in the daily management of these patients. Read More

    How I treat juvenile idiopathic arthritis: A state of the art review.
    Autoimmun Rev 2017 Oct 1;16(10):1008-1015. Epub 2017 Aug 1.
    Istituto Giannina Gaslini, Genoa, Italy; Università degli Studi di Genova, Genoa, Italy.
    Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in children and an important cause of short and long-term disability. JIA encompasses several disease categories, each of which has distinct presentation, clinical manifestations, and, presumably, genetic background and etiopathogenesis. Correct choice and timely use of available medications to achieve early and sustained remission with as few side effects as possible remain challenges for the treating physician. Read More

    Central nervous system involvement in eosinophilic granulomatosis with polyangiitis (Churg-Strauss): Report of 26 patients and review of the literature.
    Autoimmun Rev 2017 Sep 12;16(9):963-969. Epub 2017 Jul 12.
    Department of Internal Medicine, Hôpital Cochin, F-75014 Paris, France; National Referral Center for Systemic and Autoimmune Diseases, Hôpital Cochin, F-75014 Paris, France; Université Paris Descartes, Faculté de Médecine Paris Descartes, F-75014 Paris, France; Université Paris Descartes, Paris 5, Paris, France; Inserm, U1016, Institut Cochin, F-75014 Paris, France. Electronic address:
    Background: Although peripheral nervous system involvement is common in eosinophilic granulomatosis with polyangiitis (EGPA), central nervous system (CNS) manifestations are poorly described. This study aimed to describe CNS involvement in EGPA.

    Patients And Methods: This retrospective, observational, multicenter study included patients with EGPA and CNS involvement affecting cranial nerves, brain and/or spinal cord. Read More

    Clinical and pathologic implications of extending the spectrum of maternal autoantibodies reactive with ribonucleoproteins associated with cutaneous and now cardiac neonatal lupus from SSA/Ro and SSB/La to U1RNP.
    Autoimmun Rev 2017 Sep 12;16(9):980-983. Epub 2017 Jul 12.
    Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, NY, United States.
    While the relationship between maternal connective tissue diseases and neonatal rashes was described in the 1960s and congenital heart block in the 1970s, the "culprit" antibody reactivity to the SSA/Ro-SSB/La ribonucleoprotein complex was not identified until the 1980s. However, studies have shown that approximately 10-15% of cases of congenital heart block are not exposed to anti-SSA/Ro-SSB/La. Whether those cases represent a different disease entity or whether another antibody is associated has yet to be determined. Read More

    Biologics in myelodysplastic syndrome-related systemic inflammatory and autoimmune diseases: French multicenter retrospective study of 29 patients.
    Autoimmun Rev 2017 Sep 10;16(9):903-910. Epub 2017 Jul 10.
    Service de Médecine Interne, Hôpital Saint Antoine, APHP, Université Paris 6, 75012 Paris, France; Service de médecine interne, CHU Bretagnes Atlantique, Vannes, France.
    Background: Systemic inflammatory and autoimmune diseases (SIADs) associated with myelodysplastic syndromes are often difficult to treat. Corticosteroids are efficient but only usually at high doses. The use of biologics needs to be specified. Read More

    Effects of Interleukin 17 on the cardiovascular system.
    Autoimmun Rev 2017 Sep 10;16(9):984-991. Epub 2017 Jul 10.
    Immunogenomics and Inflammation Research Unit, EA 4130, Department of Immunology and Rheumatology, University of Lyon, Lyon, France. Electronic address:
    Cardiovascular diseases remain the leading cause of death worldwide and account for most of the premature mortality observed in chronic inflammatory diseases. Common mechanisms underlie these two types of disorders, where the contribution of Interleukin (IL)-17A, the founding member of the IL-17 family, is highly suspected. While the local effects of IL-17A in inflammatory disorders have been well described, those on the cardiovascular system remain less studied. Read More

    International consensus: What else can we do to improve diagnosis and therapeutic strategies in patients affected by autoimmune rheumatic diseases (rheumatoid arthritis, spondyloarthritides, systemic sclerosis, systemic lupus erythematosus, antiphospholipid syndrome and Sjogren's syndrome)?: The unmet needs and the clinical grey zone in autoimmune disease management.
    Autoimmun Rev 2017 Sep 11;16(9):911-924. Epub 2017 Jul 11.
    Department of Pathophysiology, University of Athens, Athens, Greece.
    Autoimmune diseases are a complex set of diseases characterized by immune system activation and, although many progresses have been done in the last 15years, several unmet needs in the management of these patients may be still identified. Recently, a panel of international Experts, divided in different working groups according to their clinical and scientific expertise, were asked to identify, debate and formulate a list of key unmet needs within the field of rheumatology, serving as a roadmap for research as well as support for clinicians. After a systematic review of the literature, the results and the discussions from each working group were summarised in different statements. Read More

    Autoimmune aspects of psoriasis: Heritability and autoantigens.
    Autoimmun Rev 2017 Sep 10;16(9):970-979. Epub 2017 Jul 10.
    Department of Dermatology, University Clinics, Ludwig-Maximilian-University of Munich, Munich, Germany. Electronic address:
    Chronic immune-mediated disorders (IMDs) constitute a major health burden. Understanding IMD pathogenesis is facing two major constraints: Missing heritability explaining familial clustering, and missing autoantigens. Pinpointing IMD risk genes and autoimmune targets, however, is of fundamental importance for developing novel causal therapies. Read More

    Circulating CXCL10 is increased in non-segmental vitiligo, in presence or absence of autoimmune thyroiditis.
    Autoimmun Rev 2017 Sep 8;16(9):946-950. Epub 2017 Jul 8.
    Department of Clinical and Experimental Medicine, University of Pisa, Via Savi 10, 56126 Pisa, Italy. Electronic address:
    Recently the importance of CXCL10 in the pathogenesis of non-segmental vitiligo (NSV) and autoimmune thyroid disorders (AITD) has been shown. No data are present about chemokines CXCL10 (Th1 prototype) and CCL2 (Th2 prototype) circulating levels in NSV patients with/without thyroiditis (AT). Serum CXCL10 and CCL2 have been measured in 50 consecutive NSV patients, in 40 consecutive patients with NSV and AT (NSV+AT), in 50 sex- and age-matched controls without AT (control 1) and in 40 sex- and age-matched patients with AT without NSV (control 2). Read More

    Biomarkers of disease activity in vitiligo: A systematic review.
    Autoimmun Rev 2017 Sep 8;16(9):937-945. Epub 2017 Jul 8.
    Department of Dermatology, Ghent University Hospital, Ghent, Belgium.
    The pathophysiology of vitiligo is complex although recent research has discovered several markers which are linked to vitiligo and associated with disease activity. Besides providing insights into the driving mechanisms of vitiligo, these findings could reveal potential biomarkers. Activity markers can be used to monitor disease activity in clinical trials and may also be useful in daily practice. Read More

    Bile acids and intestinal microbiota in autoimmune cholestatic liver diseases.
    Autoimmun Rev 2017 Sep 8;16(9):885-896. Epub 2017 Jul 8.
    Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, 145 Middle Shandong Road, Shanghai 200001, China. Electronic address:
    Autoimmune cholestatic liver diseases, including primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC), are manifested as an impairment of normal bile flow and excessive accumulation of potentially toxic bile acids. Endogenous bile acids are involved in the pathogenesis and progression of cholestasis. Consequently, chronic cholestasis affects the expression of bile acid transporters and nuclear receptors, and results in liver injury. Read More

    Spasticity in multiple sclerosis: Contribution of inflammation, autoimmune mediated neuronal damage and therapeutic interventions.
    Autoimmun Rev 2017 Sep 8;16(9):925-936. Epub 2017 Jul 8.
    University of Rostock, Department of Neurology, Division of Neuroimmunology, Germany.
    In contrast to other diseases that go along with spasticity (e.g. spinal cord injury), spasticity in chronic autoimmune diseases involving the CNS is complicated by the ongoing damage of neuronal networks that leads to permanent changes in the clinical picture of spasticity. Read More

    Endothelial cells: From innocent bystanders to active participants in immune responses.
    Autoimmun Rev 2017 Sep 8;16(9):951-962. Epub 2017 Jul 8.
    Amsterdam Rheumatology and Immunology Center, Department of Clinical Immunology & Rheumatology and Laboratory for Experimental Immunology, Academic Medical Center/University of Amsterdam, Amsterdam, The Netherlands. Electronic address:
    The endothelium is crucially important for the delivery of oxygen and nutrients throughout the body under homeostatic conditions. However, it also contributes to pathology, including the initiation and perpetuation of inflammation. Understanding the function of endothelial cells (ECs) in inflammatory diseases and molecular mechanisms involved may lead to novel approaches to dampen inflammation and restore homeostasis. Read More

    Does type-I interferon drive systemic autoimmunity?
    Autoimmun Rev 2017 Sep 8;16(9):897-902. Epub 2017 Jul 8.
    Inserm U1111, Lyon, France; Pediatric Rheumatology, Nephrology and Dermatology Department, Hôpital Femme-Mère-Enfant, Hospices civils de Lyon, France. Electronic address:
    Type-I interferon (IFN)-mediated immune response involves both innate and adaptive immune system and has a pivotal role in antiviral defence. A complex interplay of intracellular signaling pathways and tight regulatory systems drive the IFN activation. The observation of an aberrant stimulation of this system as a common molecular basis in peculiar inherited autoimmune and autoinflammatory disorders led to the concept of "type I interferonopathies". Read More

    The role of nailfold capillaroscopy in the assessment of internal organ involvement in systemic sclerosis: A critical review.
    Autoimmun Rev 2017 Aug 30;16(8):787-795. Epub 2017 May 30.
    Fourth Department of Internal Medicine, Hippokration University Hospital, Medical School, Aristotle University of Thessaloniki, 49 Konstantinoupoleos Street, 54642 Thessaloniki, Greece. Electronic address:
    Endothelial dysfunction and microvascular damage constitute the hallmarks of systemic sclerosis (SSc), explaining much of the pathophysiology and clinical manifestations of the disease. Nailfold videocapillaroscopy (NVC) is an established method for the assessment of the microvasculature, aiding in distinguishing different types of structural vascular abnormalities. Until recently, NVC was used in the diagnosis of SSc as well as in the assessment and follow-up of peripheral digital vasculopathy. Read More

    Targeting the programmed cell death-1 pathway in rheumatoid arthritis.
    Autoimmun Rev 2017 Aug 29;16(8):767-773. Epub 2017 May 29.
    Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, United States; Perlmutter Cancer Center, NYU School of Medicine, New York, NY, United States. Electronic address:
    Since the introduction of TNF-α inhibitors and other biologic agents, the clinical outcome for many treated rheumatoid arthritis patients has significantly improved. However, there are still a substantial proportion of patients that are intolerant, or have inadequate responses, with current agents that have become the standards of care. While the majority of these agents are designed to affect the inflammatory features of the disease, there are also agents in the clinic that instead target lymphocyte subsets (e. Read More

    Hematopoietic stem cell transplantation in autoimmune disorders: From immune-regulatory processes to clinical implications.
    Autoimmun Rev 2017 Aug 29;16(8):817-825. Epub 2017 May 29.
    Centre for Immune Regulation, Department of Immunology, University of Oslo, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
    Autoimmune diseases are characterized by the development of autoreactive T- and B-cells targeting self-antigens, which eventually can result in chronic and persistent organ damage. The autologous hematopoietic stem cell transplantation (AHSCT) opened new avenues in the treatment of patients with severe, treatment-resistant autoimmune diseases. This paper reviews the immune-regulatory mechanisms behind AHSCT, and also summarizes the experiences of clinical practice related to the therapy in organ-specific and systemic autoimmune diseases. Read More

    Late-onset Rasmussen Encephalitis: A literature appraisal.
    Autoimmun Rev 2017 Aug 29;16(8):803-810. Epub 2017 May 29.
    APHP Pitie-Salpêtrière-Charles-Foix, Epileptology Unit, Paris, France; Brain and Spine Institute (INSERM UMRS1127, CNRS UMR7225, UPMC), Paris, France.
    Rasmussen Encephalitis (RE) is classically described as a childhood encephalopathy due to a unilateral inflammation of the cerebral cortex with a presumed immune-mediated pathophysiological basis. Unusual variant forms, including adolescent and adult-onset RE have been described but there is still a doubt whether these atypical cases correspond to classical RE patients. To review evidence, a systematic PubMed search was conducted to retrieve papers addressing late onset RE to assess (i) the positivity rate of classical childhood-onset diagnostic criteria for RE in late-onset RE, (ii) the specific clinical and radiological features that could help earlier diagnosis and therapeutic interventions, (iii) the arguments for an autoimmune pathophysiology including (iiia) the association with autoimmune markers or diseases and (iiib) the effects of immunomodulatory or immunosuppressive treatments. Read More

    Myocarditis in auto-immune or auto-inflammatory diseases.
    Autoimmun Rev 2017 Aug 29;16(8):811-816. Epub 2017 May 29.
    Département de Médecine Interne et Immunologie Clinique, Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier Pitié-Salpêtrière, F-75013 Paris, France; Département Hospitalo-Universitaire I2B, UPMC Univ Paris 06, F-75013 Paris, France; INSERM, UMR 7211, F-75005 Paris, France; CNRS, UMR 7211, F-75005 Paris, France; INSERM, UMR_S 959, F-75013 Paris, France. Electronic address:
    Myocarditis is a major cause of heart disease in young patients and a common precursor of heart failure due to dilated cardiomyopathy. Some auto-immune and/or auto-inflammatory diseases may be accompanied by myocarditis, such as sarcoidosis, Behçet's disease, eosinophilic granulomatosis with polyangiitis, myositis, and systemic lupus erythematosus. However, data concerning myocarditis in such auto-immune and/or auto-inflammatory diseases are sparse. Read More

    Autophagy in neuroinflammatory diseases.
    Autoimmun Rev 2017 Aug 29;16(8):856-874. Epub 2017 May 29.
    Immunopathology and therapeutic chemistry, UPR3572 CNRS, Laboratory of excellence Medalis, 67000 Strasbourg, France. Electronic address:
    Autophagy is a metabolically-central process that is crucial in diverse areas of cell physiology. It ensures a fair balance between life and death molecular and cellular flows, and any disruption in this vital intracellular pathway can have consequences leading to major diseases such as cancer, metabolic and neurodegenerative disorders, and cardiovascular and pulmonary diseases. Recent pharmacological studies have shown evidence that small molecules and peptides able to activate or inhibit autophagy might be valuable therapeutic agents by down- or up-regulating excessive or defective autophagy, or to modulate normal autophagy to allow other drugs to repair some cell alteration or destroy some cell subsets (e. Read More

    The role of endothelial cells in the vasculopathy of systemic sclerosis: A systematic review.
    Autoimmun Rev 2017 Aug 29;16(8):774-786. Epub 2017 May 29.
    Ghent University, Department of Internal Medicine, Ghent, Belgium; Ghent University Hospital, Department of Rheumatology, Ghent, Belgium.
    Introduction: Systemic sclerosis (SSc) is an autoimmune connective tissue disorder characterized by fibroproliferative vasculopathy, immunological abnormalities and progressive fibrosis of multiple organs including the skin. In this study, all English speaking articles concerning the role of endothelial cells (ECs) in SSc vasculopathy and representing biomarkers are systematically reviewed and categorized according to endothelial cell (EC) (dys)function in SSc.

    Methods: A sensitive search on behalf of the EULAR study group on microcirculation in Rheumatic Diseases was developed in Pubmed, The Cochrane Library and Web of Science to identify articles on SSc vasculopathy and the role of ECs using the following Mesh terms: (systemic sclerosis OR scleroderma) AND pathogenesis AND (endothelial cells OR marker). Read More

    Survivin in autoimmune diseases.
    Autoimmun Rev 2017 Aug 28;16(8):845-855. Epub 2017 May 28.
    Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Rheumatology Clinic, Sahlgrenska University Hospital, Gothenburg, Sweden. Electronic address:
    Survivin is a protein functionally important for cell division, apoptosis, and possibly, for micro-RNA biogenesis. It is an established marker of malignant cell transformation. In non-malignant conditions, the unique properties of survivin make it indispensable for homeostasis of the immune system. Read More

    Repeated pulses of methyl-prednisolone with reduced doses of prednisone improve the outcome of class III, IV and V lupus nephritis: An observational comparative study of the Lupus-Cruces and lupus-Bordeaux cohorts.
    Autoimmun Rev 2017 Aug 28;16(8):826-832. Epub 2017 May 28.
    UMR CNRS 5164, ImmunoconcEpT, Bordeaux University, Bordeaux, France; Immunology Department, FHU ACRONIM, Pellegrin Hospital, Bordeaux, France.
    Objective: To compare the clinical course of patients with class III, IV and V lupus nephritis (LN) treated at Hospital Universitario Cruces (CC) and at Bordeaux University Hospital (BC).

    Methods: The Lupus-Cruces nephritis protocol combines pulses of 125mg of methyl-prednisolone with each fortnightly pulse of cyclophosphamide and prednisone ≤30mg/day with tapering over 12-14weeks until 2.5-5mg/day. Read More

    Very early and early systemic sclerosis in the Spanish scleroderma Registry (RESCLE) cohort.
    Autoimmun Rev 2017 Aug 28;16(8):796-802. Epub 2017 May 28.
    Autoimmune Unit, Department of Internal Medicine, Hospital Universitario Vall d'Hebron, Barcelona, Spain.
    Objectives: According to the existence of subclinical organ involvement pre-scleroderma should be divided into two subsets: very early and early disease. Pre-scleroderma patients included in the Spanish Scleroderma Registry (RESCLE) Cohort were reclassified into subsets. Differences were evaluated and the risk of progression to definite systemic sclerosis was estimated. Read More

    Recent advances in our understanding of giant cell arteritis pathogenesis.
    Autoimmun Rev 2017 Aug 28;16(8):833-844. Epub 2017 May 28.
    Department of Internal Medicine and Clinical Immunology, François Mitterrand Hospital, Dijon University Hospital, Dijon, France; INSERM, UMR1098, University of Bourgogne Franche-Comté, FHU INCREASE, Dijon, France.
    Giant cell arteritis (GCA) is a granulomatous vasculitis affecting large arteries, especially the aorta and the extracranial branches of the external carotid artery. Its exact pathogenesis is not fully understood but major progress has been made in recent years, leading to new therapeutic targets like inhibition of the interleukin-6 pathway or the modulation of immune checkpoints. The cause of GCA has not been clearly identified but it is thought that GCA occurs on a genetic background and is triggered by unknown environmental factors that could activate and lead to the maturation of dendritic cells localized in the adventitia of normal arteries. Read More

    1 OF 40