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    2012 results match your criteria Autoimmunity Reviews [Journal]

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    Are the ACR 2010 diagnostic criteria for fibromyalgia better than the 1990 criteria?
    Autoimmun Rev 2017 Nov 3. Epub 2017 Nov 3.
    CREATE Centre, Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, Wales, UK. Electronic address:
    Fibromyalgia (FM) is difficult to diagnose and manage chronic pain condition whose symptoms have no clear pathophysiological cause, although it is thought that patient hypersensitivity to a range of stimuli may give rise to mechanical hyperalgesia as a result of altered central nociceptive processing. The 1990 American College of Rheumatology (ACR) classification criteria, which have been widely used in clinical practice, require the existence of chronic widespread pain (CWP) for >3months, and the presence of at least 11 out of 18 specified tender points upon digital palpation, although this latter criterion has long been criticised. The newer 2010 ACR diagnostic criteria state that FM can be defined as CWP associated with somatic symptoms, and recommend the use of a widespread pain index and a scale to rate symptom severity. Read More

    Vitamin D and systemic lupus erythematosus - the hype and the hope.
    Autoimmun Rev 2017 Nov 3. Epub 2017 Nov 3.
    Arthritis Research, UK Centre for Epidemiology, Centre for Musculoskeletal Research, Faculty of Biology Medicine and Health, The University of Manchester; NIHR Manchester Biomedical Research Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
    Over the past 20years, much has been written about the potential role of vitamin D in on adverse health outcomes. In recent years, evidence has accumulated regarding the effect of vitamin D on the immune system, and its different cells. Some studies have noted lower vitamin D concentrations in patients with SLE. Read More

    TNF inhibitors in rheumatoid arthritis and spondyloarthritis: Are they the same?
    Autoimmun Rev 2017 Nov 3. Epub 2017 Nov 3.
    Rheumatology Unit, ASST Fatebenefratelli Sacco, Milan, Italy, Milan, Italy.
    The advent of anti-tumour necrosis factor (TNF) drugs for rheumatoid arthritis (RA) or spondyloarthritis (SpA) has revolutionised the approach to patients with active disease who do not respond to conventional therapy. Although there are differences in their structure, morphology, pharmacokinetic properties and activity, all anti-TNF drugs ultimately neutralise the TNFα pathway of inflammation. However, despite their similar clinical efficacy, there are disagreements concerning drug survival and safety, with systematic reviews and meta-analyses confirming one result or the other. Read More

    Can we manage lupus nephritis without chronic corticosteroids administration?
    Autoimmun Rev 2017 Nov 3. Epub 2017 Nov 3.
    Division of Nephrology, Department of Medicine, University Health Network, Toronto, Canada.
    The outcome of lupus nephritis (LN) has changed since the introduction of glucocorticoids (GCs), which dramatically reduced the mortality related to one of the most severe complications of systemic lupus erythematosus (SLE). Since the 1950's, other immunosuppressants, including biologic drugs (i.e. Read More

    Physical activity and autoimmune diseases: Get moving and manage the disease.
    Autoimmun Rev 2017 Nov 3. Epub 2017 Nov 3.
    Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Electronic address:
    Physical activity, by definition, is any skeletal muscle body movement that results in energy expenditure. In the last few decades, a plethora of scientific evidences have accumulated and confirmed the beneficial role of physical activity as a modifiable risk factor for a wide variety of chronic diseases including cardiovascular diseases (CVDs), diabetes mellitus and cancer, among others. Autoimmune diseases are a heterogeneous group of chronic diseases, which occur secondary to loss of self-antigen tolerance. Read More

    Targeting interferons and their pathways in systemic lupus erythematosus.
    Autoimmun Rev 2017 Nov 4. Epub 2017 Nov 4.
    Service de rhumatologie, Centre National de Référence des Maladies Autoimmunes et Systémiques Rares, Université de Strasbourg, INSERM UMR-S 1109, F-67000 Strasbourg, France. Electronic address:
    Significant advances in the understanding of the molecular basis of innate immunity have led to the identification of interferons (IFNs), particularly IFN-α, as central mediators in the pathogenesis of Systemic Lupus Erythematosus. Therefore, targeting of IFNs and of their downstream pathways has emerged as important developments for novel drug research in SLE. Based on this, several specific interferon blocking strategies using anti-IFN-α antibodies, anti-type I interferon receptor antibodies, Interferon-α-kinoid, or anti-IFN-γ antibodies have all been assessed in recent clinical trials. Read More

    Can we withdraw immunosuppressants in patients with lupus nephritis in remission? An expert debate.
    Autoimmun Rev 2017 Nov 3. Epub 2017 Nov 3.
    Joint Rheumatology Program, 4th Department of Medicine, "Attikon" University Hospital, National and Kapodistrian University of Athens Medical School and Biomedical Research Foundation of the Athens Academy Athens, Greece; Medical School, University of Cyprus, Nicosia, Cyprus. Electronic address:
    Lupus nephritis (LN) treatment requires an initial intensive period of therapy followed by a long-term maintenance treatment in order to stabilize disease control and eventually reach renal remission. In this section, Authors discuss the feasibility of safely lowering and even suspending maintenance therapy in LN patients having entered remission, highlighting hurdles in predicting the depth and durability of disease quiescence together with the need for minimizing potentially toxic therapies. Even though no firm conclusions can still be drawn, the treating physician has to find the wise balance between disease control and treatment-related drawbacks by following patients closely and recognizing as early as possible the ones who are likely to reach a deep and durable renal remission; there is consensus that is these are the only patients in whom a potential safe complete withdrawal can be foreseen so far. Read More

    Cocaine and ANCA associated vasculitis-like syndromes - A case series.
    Autoimmun Rev 2017 Nov 3. Epub 2017 Nov 3.
    Department of Rheumatology and Lupus, Guy's and St. Thomas' NHS Foundation Trust, London, U.K. Electronic address:
    Objectives: We analysed the spectrum of clinical manifestations of cocaine associated pseudovasculitis.

    Methods: Clinical, serological, radiological and histological features of 14 patients with cocaine pseudovasculitis syndromes were included.

    Results: Twelve patients had significant sinus thickening or erosive disease. Read More

    The Immunobiology and clinical features of type 1 autoimmune polyglandular syndrome (APS-1).
    Autoimmun Rev 2017 Nov 3. Epub 2017 Nov 3.
    Division of Rheumatology, Allergy and Clinical Immunology, School of Medicine, University of California, Davis, CA 95616, USA. Electronic address:
    Autoimmune Polyglandular Syndrome type 1 (APS-1) is a subtype of the autoimmune polyendocrine syndrome characterized by the simultaneous or sequential dysfunction of multiple endocrine or non-endocrine glands. A clinical diagnosis of APS-1 is typically based on the presence of at least two of three following criteria: chronic mucocutaneous candidiasis, hypoparathyroidism and adrenal insufficiency. The first identified causative mutated gene for APS-1 is autoimmune regulator (AIRE) encoding a critical transcription factor, which is primarily expressed in the medullary thymic epithelial cells (mTECs) for generating central immune tolerance. Read More

    Brain diffusion tensor MRI in systematic lupus erythematosus: A systematic review.
    Autoimmun Rev 2017 Nov 3. Epub 2017 Nov 3.
    Laboratory of Autoimmune Disease, State University of Campinas (UNICAMP), Brazil; Rheumatology Unit, Department of Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Brazil. Electronic address:
    Diffusion tensor imaging (DTI) maps the brain's microstructure by measuring fractional anisotropy (FA) and mean diffusivity (MD). This systematic review describes brain diffusion tensor Magnetic resonance imaging (MRI) studies in systemic lupus erythematosus (SLE).The literature was reviewed following the PRISMA guidelines and using the terms "lupus", "systemic lupus erythematosus", "SLE", "diffusion tensor imaging", "DTI", "white matter" (WM), "microstructural damage", "tractography", and "fractional anisotropy"; the search included articles published in English from January 2007 to April 2017. Read More

    Is undifferentiated spondyloarthritis a discrete entity? A debate.
    Autoimmun Rev 2017 Nov 3. Epub 2017 Nov 3.
    Rheumazentrum Ruhrgebiet, Herne, Ruhr-University Bochum, Germany.
    The concept of undifferentiated spondyloarthritis has been introduced recently to describe a clinical setting where the classical features of spondyloarthritis (SpA) are not fully present. Whether this is a discrete entity was the basis of a debate during the 4th International Congress on Controversies in Rheumatology & Autoimmunity held in Bologna, Italy 9-11 March 2017. The pro and con aspects of the debate are presented. Read More

    The roles and applications of autoantibodies in progression, diagnosis, treatment and prognosis of human malignant tumours.
    Autoimmun Rev 2017 Oct 16. Epub 2017 Oct 16.
    Department of Microbiology, Harbin Medical University, Harbin, China; Wu Lien-Teh Institute, Harbin Medical University, Harbin, China; Heilongjiang Province Key Laboratory of Immunity and Infection, Pathogenic Biology, Harbin, China. Electronic address:
    The existence of autoantibodies towards an individual's own proteins or nucleic acids has been established for more than 100years, and for a long period, these autoantibodies have been believed to be closely associated with autoimmune diseases. However, in recent years, researchers have become more interested in the role and application of autoantibodies in progression, diagnosis, treatment and prognosis of human malignant tumours. Over the past few decades, numerous epidemiological studies have shown that the risk of certain cancers is significantly altered (increased or decreased) in patients with autoimmune diseases, which suggests that autoantibodies may play either promoting or suppressing roles in cancer progression. Read More

    New insights in the pathogenesis of immunoglobulin A vasculitis (Henoch-Schönlein purpura).
    Autoimmun Rev 2017 Oct 14. Epub 2017 Oct 14.
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, De Boelelaan 1109, 1081 HZ Amsterdam, The Netherlands; Amsterdam Infection & Immunity Institute, Amsterdam, The Netherlands; Department of Surgery, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands. Electronic address:
    Immunoglobulin A vasculitis (IgAV), also referred to as Henoch-Schönlein purpura, is the most common form of childhood vasculitis. The pathogenesis of IgAV is still largely unknown. The disease is characterized by IgA1-immune deposits, complement factors and neutrophil infiltration, which is accompanied with vascular inflammation. Read More

    Interleukin-22 in human inflammatory diseases and viral infections.
    Autoimmun Rev 2017 Oct 14. Epub 2017 Oct 14.
    BiotechnologyResearch Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:
    Interleukin-22 (IL22) is one of the members of IL10 family. Elevated levels of this cytokine can be seen in diseases caused by T lymphocytes, such as Psoriasis, Rheumatoid arthritis, interstitial lung diseases. IL22 is produced by different cells in both innate and acquired immunities. Read More

    Uveitis: Diagnostic work-up. A literature review and recommendations from an expert committee.
    Autoimmun Rev 2017 Oct 14. Epub 2017 Oct 14.
    Service de Rhumatologie, Hôpital Saint-Antoine, AP-HP, UPMC Univ Paris 06, INSERM UMRS 938, DHU i2B, 75012 Paris, France.
    Purpose: Diagnosis of uveitis is difficult. Etiologic investigations should take into account the epidemiology of uveitis and should focus on the most severe forms of the disease and those which can be treated. This study was undertaken to establish recommendations for the diagnosis of uveitis. Read More

    The inter-observer reading variability in anti-nuclear antibodies indirect (ANA) immunofluorescence test: A multicenter evaluation and a review of the literature.
    Autoimmun Rev 2017 Oct 14. Epub 2017 Oct 14.
    Unit of Allergology, Immunology, Rheumatology, Department of Medicine, University Campus Bio-Medico di Roma, Rome, Italy.
    Recently there has been an increase demand for Computer-Aided Diagnosis (CAD) tools to support clinicians in the field of Indirect ImmunoFluorescence (IIF), as the novel digital imaging reading approach can help to overcome the reader subjectivity. Nevertheless, a large multicenter evaluation of the inter-observer reading variability in this field is still missing. This work fills this gap as we evaluated 556 consecutive samples, for a total of 1679 images, collected in three laboratories with IIF expertise using HEp-2 cell substrate (MBL) at 1:80 screening dilution according to conventional procedures. Read More

    Rheumatic diseases and autoimmune vascular dementia.
    Autoimmun Rev 2017 Oct 14. Epub 2017 Oct 14.
    Rheumatology Unit, L. Sacco University Hospital, Milan, Italy.
    Vascular dementia (VD) comes second after Alzheimer's disease (AD) as a cause of impaired cognition. VD is not a specific nosological entity, but rather a syndrome encompassing a number of diseases caused by impaired supply of blood to the brain. Systemic autoimmune disorders such as systemic lupus erythematosus, rheumatoid arthritis, vasculitis and antiphospholipid syndrome (APS) can be associated with dementia. Read More

    Novelties in the field of autoimmunity - 1st Saint Petersburg congress of autoimmunity, the bridge between east and west.
    Autoimmun Rev 2017 Oct 14. Epub 2017 Oct 14.
    Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Incumbent of the Laura Schwarz-Kipp chair for research of autoimmune diseases, Sackler Faculty of Medicine, Tel Aviv University, Israel; Laboratory of the Mosaic of Autoimmunity, Department of Pathology, Faculty of Medicine, Saint Petersburg State University, Russia. Electronic address:

    Cogan syndrome: Characteristics, outcome and treatment in a French nationwide retrospective study and literature review.
    Autoimmun Rev 2017 Oct 14. Epub 2017 Oct 14.
    AP-HP, Hôpital Saint-Antoine, service de médecine interne and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Sorbonne Universités, UPMC University, Paris 06, F-75012, Paris, France. Electronic address:
    Background: Cogan syndrome is mainly treated with steroids. We aimed to determine the place of DMARDs and biologic-targeted treatments.

    Patients And Methods: We conducted a French nationwide retrospective study of patients with Cogan syndrome (n=40) and a literature review of cases (n=22) and analyzed the efficacy of disease-modifying anti-rheumatic drugs (DMARDs) and tumor necrosis factor α (TNF-α) antagonists. Read More

    HLA-DRB1 alleles and juvenile idiopathic arthritis: Diagnostic clues emerging from a meta-analysis.
    Autoimmun Rev 2017 Oct 14. Epub 2017 Oct 14.
    Servizio di Epidemiologia Clinica e Biometria, Direzione Scientifica, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
    Juvenile Idiopathic Arthritis (JIA) is characterized with a variable pattern of articular involvement and systemic symptoms and, thus, it has been classified in several subtypes. Genetic predisposition to JIA is mainly due to HLA class II molecules (HLA-DRB1, HLA-DPB1), although HLA class I molecules and non-HLA genes have been implicated, too. Here, we carried out a meta-analysis including selected studies designed to assess HLA genetic background of JIA patients, compared to healthy controls; particularly, we focused our attention on HLA-DRB1. Read More

    Autoimmune comorbidity in chronic spontaneous urticaria: A systematic review.
    Autoimmun Rev 2017 Oct 14. Epub 2017 Oct 14.
    Charité - Universitätsmedizin Berlin, Department of Dermatology and Allergology, Charitéplatz 1, Berlin D-10117, Germany. Electronic address:
    Background And Objective: Numerous autoimmune diseases (AIDs) have been linked to chronic spontaneous urticaria (CSU). Here, we provide the first extensive and comprehensive evaluation of the prevalence of AIDs in patients with CSU and vice versa.

    Methods: A Pubmed and Google Scholar search was performed to identify studies reporting the prevalence of various AIDs in CSU and vice versa published before April 2017. Read More

    The management of first-line biologic therapy failures in rheumatoid arthritis: Current practice and future perspectives.
    Autoimmun Rev 2017 Oct 14. Epub 2017 Oct 14.
    Department of Rheumatology, University of Pavia, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.
    The introduction of biologic disease-modifying anti-rheumatic drugs (bDMARDs) has dramatically changed the management of rheumatoid arthritis (RA). However, in a real-life setting about 30-40% of bDMARD treated patients experience drug discontinuation because of either inefficacy or adverse events. According to international recommendations, to date the best strategy for managing first-line bDMARD failures has not been defined yet and available data (especially on TNF inhibitors [TNFis]) seem to drive toward a personalized approach for the individual patient. Read More

    Zika virus and autoimmunity. One-step forward.
    Autoimmun Rev 2017 Oct 14. Epub 2017 Oct 14.
    Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 No. 63-C-69, Bogotá, Colombia. Electronic address:
    Zika virus (ZIKV) infection has been associated with the development of Guillain-Barré syndrome (GBS) and idiopathic thrombocytopenic purpura (ITP). Whether ZIKV infection is related to other autoimmune diseases is unknown. Therefore, an association study to evaluate rheumatic and thyroid autoimmunity in patients with ZIKV disease was conducted through a panel of 14 autoantibodies. Read More

    Clinical and pathological significance of cutaneous manifestations in ANCA-associated vasculitides.
    Autoimmun Rev 2017 Nov 14;16(11):1138-1146. Epub 2017 Sep 14.
    Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France; Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Paris, France. Electronic address:
    Objectives: Cutaneous manifestations (CM) in ANCA-associated vasculitides (AAV) are frequent, but data on clinical significance and clinical-pathological correlations are lacking.

    Methods: We conducted a multicenter, retrospective study including 1553 AAV patients. Clinical, biological and pathological features have been analyzed, and tissue samples from 46 biopsies were reviewed in a blind manner. Read More

    Primary thromboprophylaxis with low-dose aspirin and antiphospholipid antibodies: Pro's and Con's.
    Autoimmun Rev 2017 Nov 11;16(11):1103-1108. Epub 2017 Sep 11.
    Department of Cardiac Thoracic and Vascular Sciences, Clinical Cardiology, Thrombosis Centre, University of Padova, Padova, Italy.
    Whether primary prophylaxis should be prescribed in individuals with antiphospholipid antibodies (aPL) remains controversial due to the lack of relevant evidence-based data. Indeed, it is unclear whether the benefit of LDA outweighs the risk of major bleeding associated with LDA in a low-risk population. On the contrary, stratification of aPL-positive subjects according to their aPL profile (combination, isotype and titer), presence of other concomitant risk factors for thrombosis and coexistence of an underling autoimmune disease is essential to decide whether primary prophylactic therapy should be prescribed. Read More

    Aortitis in giant cell arteritis: diagnosis with FDG PET/CT and agreement with CT angiography.
    Autoimmun Rev 2017 Nov 11;16(11):1131-1137. Epub 2017 Sep 11.
    Department of Nuclear Medicine, Hôpital Avicenne, Université Paris 13, Assistance Publique - Hôpitaux de Paris, Bobigny, France. Electronic address:
    Objectives: To assess the detection rate of aortitis in giant cell arteritis (GCA) with fluorodeoxyglucose positron emission tomography/computed tomography (PET) and to compare the findings with CT angiography (CTA).

    Methods: Fifty-two GCA patients and 27 controls were included. GCA patients had a PET scan at diagnosis (35/52) or during relapse (17/52). Read More

    Can we withdraw anticoagulation in patients with antiphospholipid syndrome after seroconvertion?
    Autoimmun Rev 2017 Nov 9;16(11):1109-1114. Epub 2017 Sep 9.
    Louise Coote Lupus Unit, Guy's and St Thomas' NHS Foundation Trust, London, UK.
    The current mainstay of treatment in patients with thrombotic antiphospholipid syndrome (APS) is long-term anticoagulation, mainly with Vitamin K antagonist agents. Some recently available studies have created new ground for discussion about the possible discontinuation of anticoagulation therapy in patients with a history of thrombotic APS in whom antiphospholipid antibodies (aPL) are not detected any longer (i.e. Read More

    Humanistic and cost burden of systemic sclerosis: A review of the literature.
    Autoimmun Rev 2017 Nov 9;16(11):1147-1154. Epub 2017 Sep 9.
    Boehringer Ingelheim GmbH, Ingelheim, Germany. Electronic address:
    Background: Systemic sclerosis (SSc), or systemic scleroderma, is a chronic multisystem autoimmune disease characterised by widespread vascular injury and progressive fibrosis of the skin and internal organs. Patients with SSc have decreased survival, with pulmonary involvement as the main cause of death. Current treatments for SSc manage a range of symptoms but not the cause of the disease. Read More

    The new targeted therapy in systemic lupus erythematosus: Is the glass half-full or half-empty?
    Autoimmun Rev 2017 Nov 9;16(11):1119-1124. Epub 2017 Sep 9.
    Policlinic and Hiller Research Unit for Rheumatology, UKD, Heinrich-Heine-University Duesseldorf, Germany.
    Biologic therapy is still limited in lupus, where chronic steroid exposure and wide-spectrum immunosuppression are major triggers of organ damage. In this viewpoint, the authors summarize their views for a "half-full or half-empty" glass on targeted therapy in SLE. The are several reasons for seeing the glass half-empty and in this section the authors propose a critical reflection on scarceness of novel targeted lupus therapies. Read More

    Is PET/CT essential in the diagnosis and follow-up of temporal arteritis?
    Autoimmun Rev 2017 Nov 9;16(11):1125-1130. Epub 2017 Sep 9.
    Department of Clinical and Experimental Medicine, University Hospital Gasthuisberg, Leuven, Flanders, Belgium.
    The increasing availability and improvement of imaging techniques are deeply influencing diagnosis and work-up of patients affected with vasculitis, particularly those with large vessel vasculitis (LVV). Fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET), especially when integrated with computed tomography (CT), is taking hold as a useful diagnostic technique to examine the aorta and the other large vessels in giant cell arteritis (GCA) with concomitant large vessel involvement (LV-GCA). In this paper we examined the progresses performed in this field in the last twenty years and the evidence available so far according to two different points of view ('pros' and 'cons'), in order to give a comprehensive answer to a still open question about the role of PET/CT in the diagnosis and follow-up of GCA. Read More

    Bone mineral density and vitamin D status in systemic lupus erythematosus (SLE): A systematic review.
    Autoimmun Rev 2017 Nov 9;16(11):1155-1159. Epub 2017 Sep 9.
    Hospital del Mar/Parc de Salut-Mar/IMIM, Barcelona, Spain. Electronic address:
    Despite the improvement in the quality of life of patients with SLE due to scientific and technological advances, SLE remains a disease that over the years may produce irreversible damage to patients. Osteoporosis and secondary bone fractures are two of the major causes of irreparable injury in patients with SLE. Vitamin D insufficiency may play a vital role both in reduced bone mineral density (BMD) and in the appearance of fractures, although its mechanisms of action are still unclear. Read More

    Neutrophil extracellular traps (NETs) in autoimmune diseases: A comprehensive review.
    Autoimmun Rev 2017 Nov 9;16(11):1160-1173. Epub 2017 Sep 9.
    Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea; Department of Pediatric Nephrology, Severance Children's Hospital, Seoul, Republic of Korea; Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address:
    Neutrophil extracellular traps (NETs) are fibrous networks which protrude from the membranes of activated neutrophils. NETs are found in a variety of conditions such as infection, malignancy, atherosclerosis, and autoimmune diseases including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV), psoriasis, and gout. Studies suggest that an imbalance between "NETosis," which is a process by which NETs are formed, and NET degradation may be associated with autoimmune diseases. Read More

    Is ACPA positivity the main driver for rheumatoid arthritis treatment? Pros and cons.
    Autoimmun Rev 2017 Nov 9;16(11):1096-1102. Epub 2017 Sep 9.
    Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. Electronic address:
    Rheumatoid Arthritis (RA) is an autoimmune chronic disease that is characterized by the positivity of various antibodies, the most specific being autoantibodies against citrullinated antigens (ACPA). Despite ACPA are not arthritogenic by themselves, ACPA positive individuals have high risk of RA development and ACPA positivity is associated with severe erosive phenotype and higher mortality rate compared to seronegative RA. Moreover, ACPA status is associated with favorable response to biologics targeting pathways involving autoantibody producing cells as B lymphocytes. Read More

    Should we treat congenital heart block with fluorinated corticosteroids?
    Autoimmun Rev 2017 Nov 9;16(11):1115-1118. Epub 2017 Sep 9.
    AP-HP, Cochin Hospital, Internal Medicine Department, Centre de référence maladies auto-immunes et systémiques rares, Paris, France; Université Paris Descartes-Sorbonne Paris Cité, Paris, France; INSERM U 1153, Center for Epidemiology and Statistics Sorbonne Paris Cité (CRESS), Paris, France.

    "How I treat" autoimmune diseases: State of the art on the management of rare rheumatic diseases and ANCA-associated systemic idiopathic vasculitis.
    Autoimmun Rev 2017 Oct 2;16(10):995-998. Epub 2017 Aug 2.
    Center of Research of Immunopathology and Rare Diseases - Coordinating Center of the Network for Rare Diseases of Piedmont and Aosta Valley, Department of Clinical and Biological Sciences, and University of Turin, Italy; SCU Nephrology and Dialysis Unit, S. Giovanni Bosco Hospital and University of Turin, Turin, Italy. Electronic address:
    This Special Issue of Autoimmunity Reviews constitutes summaries of presentations at the 20th International Meeting on Immunopathology and Orphan Diseases, held in Torino, Italy, 25-28th January 2017. As such, these presentations represent the state of the art on the pathophysiology of autoimmune diseases as well as the most recent insights into the management of these pathologic conditions. The latter includes both the optimal use of established drugs and approaches as well as novel knowledge on the means and consequences of targeted blocking of molecules or cellular mechanisms. Read More

    Antineutrophil cytoplasmic antibody-associated vasculitides and IgG4-related disease: A new overlap syndrome.
    Autoimmun Rev 2017 Oct 2;16(10):1036-1043. Epub 2017 Aug 2.
    Department of Internal Medicine, National Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France; Université Paris Descartes, Paris 5, Paris, France. Electronic address:
    Objective: Atypical manifestations have been described in patients with ANCA-associated vasculitides (AAV), such as pachymeningitis, orbital mass or chronic periaortitis. Because these manifestations have been associated to the spectrum of IgG4-related disease (IgG4-RD), we hypothesized that both diseases could overlap.

    Methods: We conducted a European retrospective multicenter observational study including patients fulfilling ACR and Chapel Hill criteria for AAV and IgG4-RD Comprehensive Diagnostic Criteria. Read More

    How I treat patients with adult onset Still's disease in clinical practice.
    Autoimmun Rev 2017 Oct 1;16(10):1016-1023. Epub 2017 Aug 1.
    Department of Clinical and Biological Sciences, Center of Research of Immunopathology and Rare Diseases, Coordinating Center of the Network for Rare Diseases of Piedmont and Aosta Valley, S. Giovanni Bosco Hospital and University of Turin, Turin, Italy. Electronic address:
    Adult onset Still's disease (AOSD) is a rare systemic inflammatory disease of unknown etiology characterized by four cardinal signs which are almost always present in patients: high spiking fever, arthralgia (with or without synovitis), maculo-papular salmon-pink evanescent skin rash, striking leukocytosis with neutrophilia. Here, we review the clinical features of AOSD and describe the best practice approaches for its management, reviewing available guidelines and recommendations and providing experts' insights. Read More

    Are cytokines and chemokines suitable biomarkers for Takayasu arteritis?
    Autoimmun Rev 2017 Oct 2;16(10):1071-1078. Epub 2017 Aug 2.
    Rheumatology Division, Universidade Federal de São Paulo - Escola Paulista de Medicina, Rua Botucatu, 740, 3rd Floor, São Paulo, SP zip code: 04032-900, Brazil. Electronic address:
    There is a growing need for disease related biomarkers in Takayasu arteritis (TA).The assessment of pro-inflammatory cytokines and chemokines in TA may provide a better understanding of its pathophysiology, and circulating levels of these mediators may act as biomarkers of disease activity. Serum level of interleukin 6 (IL-6) is a potential biomarker for TA, which is mostly associated with TA status and disease activity. Read More

    How I treat patients with systemic sclerosis in clinical practice.
    Autoimmun Rev 2017 Oct 1;16(10):1024-1028. Epub 2017 Aug 1.
    Rheumatology Unit, University Hospital, Padua, Italy. Electronic address:
    Systemic sclerosis (SSc) or scleroderma is a disorder of the connective tissue affecting the skin, and it is often associated with visceral involvement. The predominant pathological features of SSc are autoimmunity, vasculopathy, and fibrosis. Progressive fibrosis is associated with changes in the microcirculation of the involved organs. Read More

    Using multi-omics methods to understand dermatomyositis/polymyositis.
    Autoimmun Rev 2017 Oct 1;16(10):1044-1048. Epub 2017 Aug 1.
    Department of Rheumatology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, People's Republic of China. Electronic address:
    Idiopathic inflammatory myopathies (IIM) are a group of rare and heterogeneous autoimmune diseases, and the most common subtypes are dermatomyositis (DM) and polymyositis (PM). Despite extensive efforts, the underlying mechanism of IIM remains unclear. Recent efforts to understand the pathogenesis of IIM have included genomics, epigenetics, transcriptomics, proteomics and autoantibody studies. Read More

    The Yin and Yang of regulatory T cell and therapy progress in autoimmune disease.
    Autoimmun Rev 2017 Oct 2;16(10):1058-1070. Epub 2017 Aug 2.
    Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin 541004, China; Department of Immunology, Xiangya School of Medicine, Central South University, Changsha, Hunan 410078, China; Department of Immunology, Faculty of Basic Medicine, Guilin Medical University, Guilin 541004, China. Electronic address:
    Autoimmune diseases (ADs) are primarily mediated by the failure of immunological self-tolerance. Regulatory T cells (Tregs) play a critical role in the maintenance of induced tolerance to peripheral self-antigens, suppressing immoderate immune responses deleterious to the host and preventing the AD development. Tregs and suppressive cytokines are homeostatic with effective cells plus pro-inflammatory cytokines in healthy hosts which is defined as "Yang", and ADs are usually induced in case of disturbed homeostasis, which is defined as "Yin". Read More

    Cancer and autoimmune diseases.
    Autoimmun Rev 2017 Oct 1;16(10):1049-1057. Epub 2017 Aug 1.
    Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel; Sackler Faculty in Medicine, Sheba Medical Center, Tel-Aviv University, Israel.
    Purpose Of Review: The association between autoimmunity and cancer is well established. Cancer has been implicated in some autoimmune disorders (AID), such as scleroderma and myositis. On the other hand, many autoimmune disorders and immunosuppressive therapy, have been linked to an increased risk for cancer. Read More

    Role of anti-receptor autoantibodies in pathophysiology of scleroderma.
    Autoimmun Rev 2017 Oct 1;16(10):1029-1035. Epub 2017 Aug 1.
    Rheumatology Division, Department of Medicine, Georgetown University, United States.
    The pathophysiology of SSc-mediated organ damage is complex and not well understood. Hallmarks of the disease include skin thickening, vasculopathy and gastrointestinal dysmotility. Diverse anti-nuclear antibodies can be used as biomarkers for classification and prognosis, but their role in producing tissue pathology/organ dysfunction is not established. Read More

    Targeting interleukin-6 in autoimmune uveitis.
    Autoimmun Rev 2017 Oct 2;16(10):1079-1089. Epub 2017 Aug 2.
    Uveitis Unit, Institut Clinic d'Oftalmologia, Hospital Clinic de Barcelona, Universitat de Barcelona, Spain.
    Interleukin-6 (IL-6) is a key cytokine that is strongly up-regulated during infection and inflammation. Featuring pleiotropic activity, IL-6 is responsible for the induction of hepatic acute-phase proteins, trafficking of acute and chronic inflammatory cells, differentiation of adaptive T cell responses, homeostatic regulation, and tissue regeneration. Dysregulated IL-6 production has been associated with the development of a wide variety of systemic immune-mediated, chronic diseases, and even certain types of cancer. Read More

    How I treat idiopathic patients with inflammatory myopathies in the clinical practice.
    Autoimmun Rev 2017 Oct 2;16(10):999-1007. Epub 2017 Aug 2.
    Rheumatology Unit, Department of Medicine, University of Padova, Italy.
    Management of patients with idiopathic inflammatory myopathies (IIMs) is challenging given the systemic nature of the disease, which is often complicated by potentially life-threatening manifestations and the lack of standardized treatment regimens. Aim of this review is to provide the currently available evidence for immunotherapy in the treatment of various manifestations of IIM in order to help clinicians in the daily management of these patients. Read More

    How I treat juvenile idiopathic arthritis: A state of the art review.
    Autoimmun Rev 2017 Oct 1;16(10):1008-1015. Epub 2017 Aug 1.
    Istituto Giannina Gaslini, Genoa, Italy; Università degli Studi di Genova, Genoa, Italy.
    Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in children and an important cause of short and long-term disability. JIA encompasses several disease categories, each of which has distinct presentation, clinical manifestations, and, presumably, genetic background and etiopathogenesis. Correct choice and timely use of available medications to achieve early and sustained remission with as few side effects as possible remain challenges for the treating physician. Read More

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