2,211 results match your criteria Autoimmunity Reviews [Journal]


The study of interactions between genome and exposome in the development of systemic lupus erythematosus.

Autoimmun Rev 2019 Feb 14. Epub 2019 Feb 14.

Copenhagen Lupus and Vasculitis Clinic, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health Science, University of Copenhagen, Denmark.. Electronic address:

Systemic lupus erythematosus (SLE) is a systemic inflammatory autoimmune disease characterized by a broad spectrum of clinical and serological manifestations. This may reflect a complex and multifactorial etiology involving several identified genetic and environmental factors, though not explaining the full risk of SLE. Established SLE risk genotypes are either very rare or with modest effect sizes and twin studies indicate that other factors besides genetics must be operative in SLE etiology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autrev.2018.11.005DOI Listing
February 2019

Juvenile polyautoimmunity in a rheumatology setting.

Autoimmun Rev 2019 Feb 14. Epub 2019 Feb 14.

Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia.. Electronic address:

Overt polyautoimmunity (PolyA) corresponds to the presence of more than one well-defined autoimmune disease (AD) manifested clinically in a single patient. The current study aimed to describe the main characteristics of juvenile PolyA in a pediatric rheumatology setting and analyze the chronological aspects, index cases, familial autoimmunity, and clustering pattern. This was a cross-sectional and multicenter study in which 313 children with overt PolyA were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autrev.2018.11.006DOI Listing
February 2019
1 Read

The European registry on obstetric Antiphospholipid syndrome (EUROAPS): A survey of 1000 consecutive cases.

Autoimmun Rev 2019 Feb 14. Epub 2019 Feb 14.

Obstetrics and Gynaecology Department, High Risk Unit, Vall d'Hebron University Hospital, Universitat Autonoma, Barcelona, Spain.

Aim To analyse the clinical features, laboratory data and foetal-maternal outcomes, and follow them up on a cohort of 1000 women with obstetric antiphospholipid syndrome (OAPS).

Methods: The European Registry of OAPS became a registry within the framework of the European Forum on Antiphospholipid Antibody projects and was placed on a website in June 2010. Thirty hospitals throughout Europe have collaborated to carry out this registry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autrev.2018.12.006DOI Listing
February 2019

Enhanced type I interferon gene signature in primary antiphospholipid syndrome: Association with earlier disease onset and preeclampsia.

Autoimmun Rev 2019 Feb 14. Epub 2019 Feb 14.

Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo (USP), Brazil.

Objective: Recently, two studies demonstrated that a relevant percentage of primary antiphospholipid syndrome (PAPS) patients had an upregulation of interferon (IFN) genes. However, 20%-28% of these patients had anti-dsDNA, a highly specific systemic lupus erythematosus (SLE) autoantibody. This study aimed to determine the prevalence of the type I IFN signature in the peripheral blood mononuclear cells of PAPS patients without specific SLE autoantibodies and search for its clinical associations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autrev.2018.11.004DOI Listing
February 2019

Lethal immunoglobulins: Autoantibodies and sudden cardiac death.

Autoimmun Rev 2019 Feb 14. Epub 2019 Feb 14.

Laboratory of the Mosaics of Autoimmunity, Saint Petersburg State University, Saint-Petersburg, Russian Federation; Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Affiliated to Tel-Aviv University School of Medicine, Tel-Hashomer, Israel.

Sudden cardiac death (SCD) is an unexpected death due to cardiac causes that occurs in a short time period (generally within 1 h of symptom onset) in a person with known or unknown cardiac disease. Patients with cardiomyopathies, myocarditis, ischemic heart disease and cardiac channelopathies are at risk of SCD. However, a certain percentage of autopsy-negative cases of SCD in the young (<35 years) remain unexplained even after a post-mortem genetic testing. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autrev.2018.12.005DOI Listing
February 2019
1 Read

Blood-brain barrier disruption and neuroinflammation as pathophysiological mechanisms of the diffuse manifestations of neuropsychiatric systemic lupus erythematosus.

Autoimmun Rev 2019 Feb 11. Epub 2019 Feb 11.

Universidad de Antioquia, Facultad de Medicina, Grupo de Inmunología Celular e Inmunogenética-GICIG, Medellín, Colombia.

Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease that can involve nervous system commitment known as neuropsychiatric systemic lupus erythematosus (NPSLE). The diagnostic of NPSLE is complex because the symptoms range from focal symptoms (e.g. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autrev.2018.12.004DOI Listing
February 2019

Conceptual, statistical and clinical interpretation of results from a systematic review and meta-analysis of prevalence of cervical HPV infection in women with SLE.

Autoimmun Rev 2019 Feb 11. Epub 2019 Feb 11.

The University of Adelaide, North Terrace Campus, Adelaide, South Australia 5005, Australia.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15689972193003
Publisher Site
http://dx.doi.org/10.1016/j.autrev.2018.12.003DOI Listing
February 2019
2 Reads

Reply to the editor.

Autoimmun Rev 2019 Feb 8. Epub 2019 Feb 8.

Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Catalonia, Spain. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15689972193003
Publisher Site
http://dx.doi.org/10.1016/j.autrev.2019.02.007DOI Listing
February 2019
5 Reads

Rituximab therapy for primary central nervous system vasculitis: A 6 patient experience and review of the literature.

Autoimmun Rev 2019 Feb 8. Epub 2019 Feb 8.

Division of Rheumatology, Mayo Clinic, Rochester, MN, United States.

Objectives: To assess the efficacy and safety of Rituximab (RTX) in adult primary central nervous system vasculitis (PCNSV).

Methods: We retrospectively assessed the effect of RTX in 6 patients with PCNSV. Five of the 6 were refractory to high dose glucocorticoids (GCs) and/or conventional immunosuppressants (IS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autrev.2018.12.002DOI Listing
February 2019
1 Read

Microvascular heart involvement in systemic autoimmune diseases: The purinergic pathway and therapeutic insights from the biology of the diseases.

Autoimmun Rev 2019 Feb 7. Epub 2019 Feb 7.

Institute of Rheumatology, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli - Presidio Columbus, Rome, Italy. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autrev.2019.02.002DOI Listing
February 2019
2 Reads

Pemphigus and mucous membrane pemphigoid: An update from diagnosis to therapy.

Autoimmun Rev 2019 Feb 7. Epub 2019 Feb 7.

Department of Biomedical Sciences and Human Oncology, Unit of Internal Medicine "Guido Baccelli", University of Bari Medical School, Bari, Italy. Electronic address:

Pemphigus diseases (PDs) and mucous membrane pemphigoid (MMP) are a group of immune-mediated mucocutaneous disorders clinically characterized by the formation of blisters, erosions and ulcers. The skin and mucous membranes are predominantly affected, with the oropharyngeal mucosa as the initially involved site. Ocular involvement is also a frequent feature of these diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autrev.2019.02.005DOI Listing
February 2019
9 Reads

Immune checkpoints and the regulation of tolerogenicity in dendritic cells: Implications for autoimmunity and immunotherapy.

Autoimmun Rev 2019 Feb 8. Epub 2019 Feb 8.

Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile; Departamento de Endocrinología, Escuela de Medicina, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. Electronic address:

The immune system is responsible for defending the host from a large variety of potential pathogens, while simultaneously avoiding immune reactivity towards self-components. Self-tolerance has to be tightly maintained throughout several central and peripheral processes; immune checkpoints are imperative for regulating the immunity/tolerance balance. Dendritic cells (DCs) are specialized cells that capture antigens, and either activate or inhibit antigen-specific T cells. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15689972193003
Publisher Site
http://dx.doi.org/10.1016/j.autrev.2019.02.006DOI Listing
February 2019
2 Reads

A review of the evidence for a natalizumab exit strategy for patients with multiple sclerosis.

Autoimmun Rev 2019 Jan 11. Epub 2019 Jan 11.

Department of Neurology, Medical University of Vienna, Vienna, Austria.

Natalizumab is an effective treatment for relapsing-remitting multiple sclerosis (RRMS), but treatment for >2 years is associated with an increased risk of opportunistic infection and progressive multifocal leukoencephalopathy (PML). For this reason, patients and physicians may consider discontinuing natalizumab therapy. This article reviews the evidence for the various therapeutic approaches that may be taken in such patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autrev.2018.09.012DOI Listing
January 2019
2 Reads

Complex regional pain syndrome - False hopes and miscommunications.

Autoimmun Rev 2019 Jan 11. Epub 2019 Jan 11.

Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, United States. Electronic address:

Complex regional pain syndrome (CRPS) has been considered to be an autoimmune disease and there have been clinical trials with intravenous immunoglobulin. Often the etiology of the so-called CRPS diagnosis cannot be discerned and there are no validated instruments that provide functional metrics. The term complex regional pain syndrome (CRPS), coined in 1994 to describe patients in whom the pain is out of proportion to the injury, was actually a diagnosis proposed during the American Civil War, but was originally known as causalgia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autrev.2018.10.003DOI Listing
January 2019
8 Reads

Review: Myositis-specific autoantibodies, a cornerstone in immune-mediated necrotizing myopathy.

Autoimmun Rev 2019 Jan 11. Epub 2019 Jan 11.

Department of Internal Medicine and Clinical Immunology, Sorbonne Université, Pitié-Salpêtrière University Hospital, Paris, France; Institut National de la Santé et de la Recherche Médicale, Association Institut de Myologie, Centre de Recherche en Myologie, UMRS974, Paris, France. Electronic address:

Over the past few years, myositis-specific autoantibodies played an increasing role in the inflammatory idiopathic myositis definition. They became the critical immunological marker for immune-mediated necrotizing myopathy diagnosis (IMNM) since the paradigm switch from histological to serological criteria. This review is focused on the key role of the anti-signal recognition particle (anti-SRP) and the anti-3-Hydroxy-3-MethylGlutaryl-Coenzyme A Reductase (anti-HMGCR) antibodies in immune-mediated necrotizing myopathy. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15689972193000
Publisher Site
http://dx.doi.org/10.1016/j.autrev.2018.09.008DOI Listing
January 2019
13 Reads

Mechanisms of action and historical facts on the use of intravenous immunoglobulins in systemic lupus erythematosus.

Autoimmun Rev 2019 Jan 11. Epub 2019 Jan 11.

GIRAT: Grupo de Investigación en Reumatología, Autoinmunidad y Medicina traslacional. Fundación Valle del Lili, Univesidad Icesi, Colombia; Laboratory of immunology, Fundación Valle del Lili, Cali, Colombia. Electronic address:

The current existing therapies for severe cases of systemic lupus erythematosus (SLE) patients are still limited. Intravenous immunoglobulin (IVIGs), which are purified from the plasma of thousands of healthy human donors, have been profiled as efficacious and life-saving options for SLE patients refractory to conventional therapy. The specific mechanism of action by which IVIGs generate immunomodulation in SLE is not currently understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autrev.2018.10.002DOI Listing
January 2019
3 Reads

Effectiveness and safety of rituximab for the treatment of refractory systemic sclerosis associated calcinosis: A case series and systematic review of the literature.

Autoimmun Rev 2019 Jan 11. Epub 2019 Jan 11.

Department of Clinical Immunology and Rheumatology, Pontificia Universidad Católica de Chile, Chile.

Objective: To analyze the effectiveness and safety of rituximab (RTX) for the treatment of refractory systemic sclerosis (SSc)-associated calcinosis.

Methods: We undertook an observational study of patients with this complication treated with 1 or more cycles of RTX (1 g × 2 weeks) and evaluated for at least 12 months after RTX treatment in a single center. The primary outcome measures of the study were the improvement of calcinosis symptoms (pain, signs of local inflammation, and new episodes of skin ulceration) and the radiologic evolution of the calcification(s). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autrev.2018.10.006DOI Listing
January 2019
2 Reads

The association of other autoimmune diseases in patients with Graves' disease (with or without ophthalmopathy): Review of the literature and report of a large series.

Autoimmun Rev 2019 Jan 11. Epub 2019 Jan 11.

Department of Clinical and Experimental Medicine, University of Pisa, Via Savi 10, Pisa 56126, Italy. Electronic address:

Graves' disease (GD) and autoimmune thyroiditis (AT) are the two main clinical presentations of AITD, and their clinical hallmarks are thyrotoxicosis and hypothyroidism, respectively. GD, and AT, can be associated with other organ specific, or systemic autoimmune diseases in the same patient. However discordant results have been reported in the literature about the possible associations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autrev.2018.10.001DOI Listing
January 2019
11 Reads

Innate immune-responses and their role in driving autoimmunity.

Autoimmun Rev 2019 Jan 11. Epub 2019 Jan 11.

Division of Allergy and Clinical Immunology, Bnai-Zion Medical Center, Faculty of Medicine, Technion, Haifa, Israel. Electronic address:

Autoimmunity and autoimmune diseases were always considered to be driven mainly by adaptive immune responses, namely by auto-reactive B and T cell over-activity. The continuous stimulation of dendritic cells by autoantigens increases B cell activity, driving auto-reactive B cells to increase the production of autoantibodies and of pro-inflammatory cytokines. On the other hand, a subset of dendritic cells is established being of tolerogenic properties thus becoming important in maintaining self-tolerance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autrev.2018.10.005DOI Listing
January 2019
2 Reads

The impact of self-replicating proteins on inflammation, autoimmunity and neurodegeneration-An untraveled path.

Autoimmun Rev 2019 Jan 11. Epub 2019 Jan 11.

Sheba Medical Center, Israel; Robert and Martha Harden Chair in Mental and Neurological Diseases, Sackler Faculty of Medicine, Tel Aviv University, Israel.

The central nervous system (CNS) in neurodegenerative diseases is a battlefield in which microglia fight a highly atypical battle. During the inflammatory process microglia themselves become dysfunctional and even with all the available immune arsenal including cytokine or/and antibody production, the battle is eventually lost. A closer look into the picture will reveal the fact that this is mainly due to the atypical characteristics of the infectious agent. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autrev.2018.09.009DOI Listing
January 2019
9 Reads

Autoantibodies in idiopathic inflammatory myopathies: Clinical associations and laboratory evaluation by mono- and multispecific immunoassays.

Autoimmun Rev 2019 Jan 11. Epub 2019 Jan 11.

Department of Microbiology and Immunology, Experimental Laboratory Immunology, KU Leuven, Leuven, Belgium; Laboratory of Medicine, University Hospitals Leuven, Leuven, Belgium. Electronic address:

Idiopathic inflammatory myopathies (IIM) are a group of diseases characterized by immune-mediated muscular lesions that may be associated with extra-muscular manifestations involving skin, lungs, heart or joints. Four main groups of IIM can be distinguished: dermatomyositis (DM), overlap myositis including mainly anti-synthetase syndrome (ASS), immune mediated necrotizing myopathy (IMNM), and inclusion body myositis (IBM). Myositis-specific autoantibodies (MSA) are increasingly recognized as valuable tools for diagnosis, classification and prognosis of IIM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autrev.2018.10.004DOI Listing
January 2019
2 Reads
7.933 Impact Factor

Autoimmunity in celiac disease: Extra-intestinal manifestations.

Autoimmun Rev 2019 Jan 11. Epub 2019 Jan 11.

AESKU.KIPP Institute, Wendelsheim, Germany.

Celiac disease is an autoimmune condition of the small intestine caused by prolamins in genetically susceptible individuals evoked by multiple environmental factors. The pathological luminal intricate eco-events produce multiple signals that irradiate the entire body, resulting in a plethora of extra-intestinal manifestations. Nutrients, dysbiosis, dysbiotic components and their mobilome, post-translational modification of naive proteins, inter-enterocyte's tight junction dysfunction resulting in a leaky gut, microbial lateral genetic transfer of virulent genes, the sensing network of the enteric nervous systems and the ensuing pro-inflammatory messengers are mutually orchestrating the autoimmune interplay. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autrev.2018.09.010DOI Listing
January 2019
1 Read

Take a look at the eyes in Systemic Lupus Erythematosus: A novel point of view.

Autoimmun Rev 2019 Jan 11. Epub 2019 Jan 11.

Rheumatology, Allergology and Clinical Immunology, Department of "Medicina dei Sistemi", University of Rome Tor Vergata, Italy.

Systemic Lupus Erythematosus (SLE) is a connective tissue disease that involves multiple organs. Ocular structures and visual pathways can be affected in SLE because of disease-related eye involvement or drug toxicity. All the part of the eye may be interested with an external, anterior involvement, responsible of the dry eye disease, or posterior (retina) and neuro-ophtalmic manifestations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autrev.2018.09.011DOI Listing
January 2019
2 Reads

Beyond medicine: Physical exercise should be always considered in patients with systemic autoimmune myopathies.

Autoimmun Rev 2019 Jan 11. Epub 2019 Jan 11.

Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, SP, Brazil (BR). Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autrev.2018.11.003DOI Listing
January 2019
1 Read

The changing face of chronic autoimmune atrophic gastritis: an updated comprehensive perspective.

Autoimmun Rev 2019 Jan 11. Epub 2019 Jan 11.

Division of Gastroenterology and Center for Autoimmune Liver Diseases, ASST San Gerardo Hospital, Department of Medicine and Surgery, University of Milan Bicocca, Monza, Italy.

Chronic autoimmune atrophic gastritis (CAAG) is an organ-specific autoimmune disease, which affects the corpus-fundus gastric mucosa. Although it has been described for several years, the real pathophysiological mechanisms, the natural history and the possible neoplastic complications are not completely known. Atrophy of the gastric mucosa is the endpoint of the chronic processes, with the loss of glandular cells and their replacement by intestinal-type epithelium, pyloric-type glands, and fibrous tissue. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autrev.2018.08.011DOI Listing
January 2019
5 Reads

Corrigendum to 'The role of dietary sodium in autoimmune diseases: The salty truth' [AUTREV 17-11 (2018) 1069-1073].

Autoimmun Rev 2019 Feb 23;18(2):214. Epub 2018 Dec 23.

Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases, Tel-Aviv University, Israel; Laboratory of the Mosaics of Autoimmunity, Saint-Petersburg University, Saint-Petersburg, Russian Federation. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autrev.2018.12.001DOI Listing
February 2019
3 Reads

Letter to the Editor: Protein phosphatase 1 subunit Ppp1r15a/GADD34 is overexpressed in systemic lupus erythematosus and related to the expression of type I interferon response genes.

Autoimmun Rev 2019 Feb 19;18(2):211-213. Epub 2018 Dec 19.

Laboratoire d'Immunologie, Pôle de Biologie, Centre Hospitalier Universitaire Grenoble Alpes, CS 10217, 38043 Grenoble, Cedex 9, France; BNI Team, TIMC-IMAG UMR5525, Université Grenoble Alpes, CNRS, BP170, 38042 Grenoble, Cedex 9, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autrev.2018.09.007DOI Listing
February 2019
3 Reads

An evolving redefinition of autoimmune encephalitis.

Autoimmun Rev 2019 Feb 18;18(2):155-163. Epub 2018 Dec 18.

Institute of Pediatrics, Università Cattolica Sacro Cuore, Rome, Italy; Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Autoimmune encephalitis encompasses a wide variety of protean pathologic processes associated with the presence of antibodies against neuronal intracellular proteins, synaptic receptors, ion channels and/or neuronal surface proteins. This type of encephalitis can also involve children with complex patterns of seizures and unexpected behavioural changes, which jeopardize their prompt recognition and treatment. Many epidemiological studies have shown that numerous immune-based forms of encephalitis can be encountered, almost surpassing the rate of postinfectious encephalitides. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15689972183029
Publisher Site
http://dx.doi.org/10.1016/j.autrev.2018.08.009DOI Listing
February 2019
6 Reads

STAT signaling as a marker of SLE disease severity and implications for clinical therapy.

Autoimmun Rev 2019 Feb 18;18(2):144-154. Epub 2018 Dec 18.

Department of Allergology, Rheumatology and Clinical Immunology, University Children's Hospital, University Medical Center Ljubljana, Ljubljana SI-1525, Slovenia; Department of Pediatrics, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. Electronic address:

The Janus kinase/signal transduction and activator of transcription (JAK-STAT) signaling pathway is implicated in the pathogenesis of autoimmune diseases, including systemic lupus erythematosus (SLE). While small-molecule JAK inhibitors (Jakinibs) are currently under investigation for SLE, results of recent studies suggest, that the efficacy of drugs such as methotrexate (MTX) may also be due to their ability to suppress phosphorylation of STAT proteins. A previously identified STAT5 phosphorylation (pSTAT5) and STAT1 protein expression »signature« in circulating CD4+ T cells of patients with SLE was associated with perturbed homeostasis between conventional (Tcon) and activated regulatory (aTreg) subset and with time-adjusted cumulative disease activity during follow-up. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autrev.2018.08.010DOI Listing
February 2019
2 Reads

Prevalence of cervical HPV infection in women with systemic lupus erythematosus: A systematic review and meta-analysis.

Autoimmun Rev 2019 Feb 18;18(2):184-191. Epub 2018 Dec 18.

Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Catalonia, Spain. Electronic address:

Objective: The objectives of this systematic review and meta-regression were: 1) to compare the prevalence of cervical HPV infection between SLE patients and healthy controls and 2) to evaluate the relationship between cervical HPV infection and traditional and SLE-related risk factors for cervical HPV infection in these patients.

Methods: We conducted a systematic literature review (PubMed, Cochrane Library, Embase, Virtual Health Library and SciELO databases) following PRISMA guidelines and using meta-regression to investigate the pooled prevalence of cervical HPV infection in adult women with SLE. The articles included were independently evaluated by two investigators who extracted information on study characteristics, defined outcomes, risk of bias and summarized strength of evidence [Quality of evidence using the Oxford Centre for evidence-based medicine (EBM) Levels of Evidence]. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15689972183028
Publisher Site
http://dx.doi.org/10.1016/j.autrev.2018.09.001DOI Listing
February 2019
12 Reads

Nailfold avascular score and coronary microvascular dysfunction in systemic sclerosis: A newsworthy association.

Autoimmun Rev 2019 Feb 18;18(2):177-183. Epub 2018 Dec 18.

Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy.

Background And Aims: We aimed to assess the relationship between nailfold videocapillaroscopy (NVC) abnormalities and coronary flow reserve (CFR), a marker of coronary microvascular dysfunction (CMD) in patients with systemic sclerosis (SSc).

Methods: We studied 39 SSc patients (33 females, mean ± SD age 54 ± 12 years, median disease duration 11 years, range 6-22) and 22 controls (matched for age and sex) without any evidence of cardiovascular disease. Clinical assessment was performed by modified Rodnan skin score (mRss) and EUSTAR score. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autrev.2018.09.002DOI Listing
February 2019
1 Read

Novel autoantibodies in Sjögren's syndrome: A comprehensive review.

Autoimmun Rev 2019 Feb 18;18(2):192-198. Epub 2018 Dec 18.

Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Vasco de Quiroga No. 15, Col. Belisario Domínguez Sección XVI., CP 14080 Mexico City, Mexico.. Electronic address:

Sjögren's syndrome is a systemic autoimmune disease characterized by immune- mediated injury of exocrine glands, as well as a diverse array of extraglandular manifestations. B cell over-activation is a key feature of the disease, attested by the wide spectrum of autoantibodies detected in these patients. Up to date, anti- Ro/SSA and anti-La/SSB antibodies are traditional biomarkers for disease classification and diagnosis. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15689972183029
Publisher Site
http://dx.doi.org/10.1016/j.autrev.2018.09.003DOI Listing
February 2019
10 Reads

Novel Sjögren's autoantibodies found in fibromyalgia patients with sicca and/or xerostomia.

Autoimmun Rev 2019 Feb 18;18(2):199-202. Epub 2018 Dec 18.

Department of Medicine, Rutgers-Robert Wood Johnson University Hospital, New Brunswick, NJ, USA.

Introduction: A significant proportion of patients with fibromyalgia (FM) complain of dry eyes and mouth. Many Sjögren's syndrome (SS) patients also complain of FM symptoms, and there is literature that suggests that there is interplay between these two disorders. Recently, the presence of novel tissue specific autoantibodies (TSAs), SP-1, CA6, and PSP, has been observed in the early stages of SS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autrev.2018.09.004DOI Listing
February 2019
3 Reads

Bispecific antibodies: The next generation of targeted inflammatory bowel disease therapies.

Autoimmun Rev 2019 Feb 17;18(2):123-128. Epub 2018 Dec 17.

Eli Lilly Biotechnology Center, Eli Lilly and Co, San Diego, CA, USA.

Targeting various disease pathways using monoclonal antibodies (mAbs) has transformed the treatment paradigm for inflammatory bowel disease (IBD), with these agents exhibiting improved efficacy over corticosteroids or immunosuppressive therapies. Antibodies targeting tumor necrosis factor α (TNF-α) were the first approved biologics for IBD, followed by the more recent approval of antibodies targeting the α4β7 integrin heterodimer and ustekinumab, which targets the p40 subunit of interleukin-23. Current efforts are focused on the development of additional biologics targeting these known and other newly discovered pathways. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autrev.2018.07.014DOI Listing
February 2019
10 Reads

Th17 cells in renal inflammation and autoimmunity.

Autoimmun Rev 2019 Feb 17;18(2):129-136. Epub 2018 Dec 17.

Department of Nephrology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. Electronic address:

Th17 cells are a distinct lineage of T-cells. These T-cells express IL-17A and the lineage-defining transcription factor RORγt. Th17 cells have a pivotal, physiological role in host defense against pathogens. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autrev.2018.08.006DOI Listing
February 2019
3 Reads

Disease activity assessment of rheumatic diseases during pregnancy: a comprehensive review of indices used in clinical studies.

Autoimmun Rev 2019 Feb 18;18(2):164-176. Epub 2018 Dec 18.

Rheumatology and Clinical Immunology, Spedali Civili and Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy; Department of Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy.

Pregnancy requires a special management in women with inflammatory rheumatic diseases (RDs), with the aim of controlling maternal disease activity and avoiding fetal complications. Despite the heterogeneous course of RDs during pregnancy, their impact on pregnancy largely relates to the extent of active inflammation at the time of conception. Therefore, accurate evaluation of disease activity is crucial for the best management of pregnant patients. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15689972183028
Publisher Site
http://dx.doi.org/10.1016/j.autrev.2018.08.008DOI Listing
February 2019
7 Reads

Lymphomagenesis in Sjögren's syndrome: Predictive biomarkers towards precision medicine.

Autoimmun Rev 2019 Feb 17;18(2):137-143. Epub 2018 Dec 17.

Department of Pathophysiology, School of Medicine, University of Athens, Mikras Asias Str 75, 115 27 Athens, Greece. Electronic address:

Sjögren's syndrome (SS) is characterized by B cell hyperactivity documented by the production of plethora of autoantibodies and a strong tendency for NHL of B cell origin. Classical predictors of lymphoma have been already proposed and proved their validity, including clinical, serological and histopathologic biomarkers. The process of lymphomagenesis is multistep and encompasses mechanisms of antigen driven selection of the BCR with RF activity and various genetic contributors implicated in B cell proliferation, cell growth and cell cycle control, enhanced by a complex milieu of cytokines and trophic agents that are abundant within the inflammatory lesion of minor salivary glands of SS patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autrev.2018.08.007DOI Listing
February 2019
2 Reads

Autoimmune pancreatitis in children: The impact of immune system in a challenging disease.

Autoimmun Rev 2019 Feb 17;18(2):209-210. Epub 2018 Dec 17.

Institute of Pediatrics, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Università Cattolica Sacro Cuore, Rome, Italy.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15689972183029
Publisher Site
http://dx.doi.org/10.1016/j.autrev.2018.09.006DOI Listing
February 2019
7 Reads

Treatment of idiopathic inflammatory myositis associated interstitial lung disease: A systematic review and meta-analysis.

Autoimmun Rev 2019 Feb 17;18(2):113-122. Epub 2018 Dec 17.

Department of Internal and Vascular Medicine, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Pierre-Bénite F-69310, France; Department of Internal and Vascular Medicine, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon F-69003, France. Electronic address:

Objective: Interstitial lung disease (ILD) is the most severe complication of idiopathic inflammatory myositis (IIM), resulting in significant increase in morbidity and mortality and for which the best treatment remains controversial. We conducted a meta-analysis to evaluate the efficacy of therapies used for the management of IIM-related ILD.

Methods: Studies were selected from MEDLINE up to July 2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autrev.2018.07.013DOI Listing
February 2019
2 Reads

The future landscape of biosimilars in rheumatology: Where we are where we are going.

Autoimmun Rev 2019 Feb 18;18(2):203-208. Epub 2018 Dec 18.

Federal University of Parana, Rheumatology Unit, Department of Internal Medicine, Brazil.

Introduction: The upcoming of biosimilars in rheumatic diseases have generated considerable interest throughout the past five years among pharmaceutical industries and regulatory agencies, their development is associated with considerable variation and heterogeneity on the variable requirements for license and marketing throughout the various continents.

Aim: In this article we reviewed the contents of the conference presented on the last XI International Conference in Autoimmunity in Lisbon.

Evidence: Truly biosimilars that followed requirements from stringent agencies are now available and licensed for infliximab, etanercept, adalimumab and rituximab but several compounds from the same mechanism of action are also being developed and are reviewed and the strengths of their evidence analized and discussed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autrev.2018.09.005DOI Listing
February 2019
1 Read

Characterization of the thymus in Lrp4 myasthenia gravis: Four cases.

Autoimmun Rev 2019 Jan 8;18(1):50-55. Epub 2018 Nov 8.

Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, the Netherlands. Electronic address:

Myasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction. Most patients have pathogenic autoantibodies against the acetylcholine receptor (AChR). In the last years a novel subpopulation of MG patients has been described that harbors antibodies against low-density lipoprotein receptor-related protein 4 (Lrp4), another postsynaptic neuromuscular antigen. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15689972183026
Publisher Site
http://dx.doi.org/10.1016/j.autrev.2018.07.011DOI Listing
January 2019
24 Reads
7.933 Impact Factor

X chromosome and female bias in systemic lupus erythematosus: Focus on population-based evidence.

Autoimmun Rev 2019 Jan 5;18(1):109-111. Epub 2018 Nov 5.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei, Anhui, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autrev.2018.08.005DOI Listing
January 2019
3 Reads

Diagnostic performance of temporal artery ultrasound for the diagnosis of giant cell arteritis: a systematic review and meta-analysis of the literature.

Autoimmun Rev 2019 Jan 5;18(1):56-61. Epub 2018 Nov 5.

Service de rhumatologie, Hôpitaux Universitaires de Strasbourg, Université de Strasbourg, Centre National de Référence des Maladies Systémiques Autoimmunes Rares RESO, F-67000 Strasbourg, France. Electronic address:

Despite major recent advances in the therapeutic management of Giant cell arteritis (GCA), the diagnosis accuracy of temporal artery ultrasound remains controversial in this disease. We performed a systematic review to determine the sensitivity, specificity, and summary positive (LR+) and negative (LR-) likelihood ratios of temporal artery ultrasound for the diagnosis of GCA. For this, we searched EMBASE, MEDLINE and the Cochrane Database of Systematic Reviews without language restriction. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15689972183026
Publisher Site
http://dx.doi.org/10.1016/j.autrev.2018.07.012DOI Listing
January 2019
23 Reads

Liver-associated immune abnormalities.

Autoimmun Rev 2019 Jan 5;18(1):15-20. Epub 2018 Nov 5.

University of Toronto, Toronto, Ontario, Canada; Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Hospital for Sick Children, Toronto, Canada.

In recent years, the cross talk between the liver and the immune system is being uncovered, in part by studying liver involvement in primary immune deficiencies (PID) and in part by investigating the alterations of the immune system following orthotopic liver transplantation (OLT). Here we review some of the reciprocal interactions between the liver and the immune system. Patients with PID, particularly those involving inherited defects in T and B cells or innate immunity are prone to infections and inflammatory responses that often involve the liver. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15689972183025
Publisher Site
http://dx.doi.org/10.1016/j.autrev.2018.06.016DOI Listing
January 2019
11 Reads

Validation and meta-analysis of kappa index biomarker in multiple sclerosis diagnosis.

Autoimmun Rev 2019 Jan 5;18(1):43-49. Epub 2018 Nov 5.

Unidad de Gestión Clínica de Neurología y Neurofisiología, Hospital Universitario Virgen Macarena, Seville, Spain.

The importance of studying the cerebrospinal fluid (CSF) in Multiple Sclerosis (MS) is included in the last McDonald criteria (2018). The study of oligoclonal IgG bands (OCGB) assay is strongly recommended in some situations in which MS diagnosis is uncertain. New biomarkers are developed during the last years. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15689972183025
Publisher Site
http://dx.doi.org/10.1016/j.autrev.2018.07.010DOI Listing
January 2019
15 Reads

Arthritis in primary Sjögren's syndrome: Characteristics, outcome and treatment from French multicenter retrospective study.

Autoimmun Rev 2019 Jan 5;18(1):9-14. Epub 2018 Nov 5.

Service de médecine interne, Hôpital Saint-Antoine, APHP, Paris, France; Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine (CRSA), F-75012 Paris, France. Electronic address:

Objective: To describe the characteristics and the outcome of primary Sjögren Syndrome (pSS) associated arthritis and to compare the efficacy of different therapeutic regimen.

Methods: We conducted a retrospective study using Club Rhumatisme and Inflammation (CRI) and French Internal Medicine Society (SNFMI) networks. All patients with a diagnosis of pSS and at least one episode of clinical and/or echographic synovitis were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autrev.2018.06.015DOI Listing
January 2019
17 Reads

The characteristics and pivotal roles of triggering receptor expressed on myeloid cells-1 in autoimmune diseases.

Autoimmun Rev 2019 Jan 5;18(1):25-35. Epub 2018 Nov 5.

School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou 325035, Zhejiang Province, China. Electronic address:

Triggering receptor expressed on myeloid cells-1 (TREM-1) engagement can directly trigger inflammation or amplify an inflammatory response by synergizing with TLRs or NLRs. Autoimmune diseases are a family of chronic systemic inflammatory disorders. The pivotal role of TREM-1 in inflammation makes it important to explore its immunological effects in autoimmune diseases. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15689972183025
Publisher Site
http://dx.doi.org/10.1016/j.autrev.2018.07.008DOI Listing
January 2019
12 Reads

Autoimmune diseases in myelodysplastic syndrome favors patients survival: A case control study and literature review.

Autoimmun Rev 2019 Jan 5;18(1):36-42. Epub 2018 Nov 5.

Aix-Marseille Univ, APHM, Medecine Interne Hôpital de la Timone, Marseille, France. Electronic address:

Background: We conducted a monocentric retrospective study of patients with myelodysplastic syndromes (MDS) and autoimmune or inflammatory disorders (AIMs) and a literature review. We analyzed the association with subgroups of the WHO 2016 MDS classification and patient's survival in a case control study. Risk factors associated with survival were analyzed by uni- and multivariate analysis. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15689972183025
Publisher Site
http://dx.doi.org/10.1016/j.autrev.2018.07.009DOI Listing
January 2019
26 Reads