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    2050 results match your criteria Autoimmunity Reviews [Journal]

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    The effect of non-TNF-targeted biologics and small molecules on insulin resistance in inflammatory arthritis.
    Autoimmun Rev 2018 Feb 13. Epub 2018 Feb 13.
    Department of Health Sciences, University of Catanzaro "Magna Graecia", Catanzaro, Italy.
    Inflammatory arthritides are chronic diseases characterised by an increase in cardiovascular risk, largely attributable to the synergy between high-grade systemic inflammation and an elevated prevalence of traditional cardiovascular risk factors. Amongst the latter, insulin resistance and type 2 diabetes (T2D) play a key position. Previous studies demonstrated a potential insulin-sensitizing effect of anti-TNF biologic medications. Read More

    Olfactory function in systemic lupus erythematosus and systemic sclerosis. A longitudinal study and review of the literature.
    Autoimmun Rev 2018 Feb 11. Epub 2018 Feb 11.
    Rheumatology Lab, School of Medical Sciences, University of Campinas; Autoimmunity Lab School of Medical Sciences, University of Campinas; Department of Medicine, Rheumatology Unit, School of Medical Sciences, University of Campinas. Electronic address:
    Background/purpose: To evaluate olfactory function in systemic lupus erythematosus (SLE), systemic sclerosis (SSc) and healthy controls over a 2-year period, and to determine the association of olfactory dysfunction with age, disease activity, disease damage, treatment, anxiety and depression symptoms and limbic structures volumes.

    Methods: Consecutive SLE and SSc patients were enrolled in this study. Clinical, laboratory disease activity and damage were assessed according to diseases specific guidelines. Read More

    Cellular immune regulation in the pathogenesis of ANCA-associated vasculitides.
    Autoimmun Rev 2018 Feb 9. Epub 2018 Feb 9.
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9713 GZ, The Netherlands; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9713 GZ, The Netherlands.
    Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides (AAV) are systemic autoimmune diseases characterized by necrotizing inflammation of small- to medium-sized blood vessels, affecting primarily the lungs and kidneys. Both animal and human studies show that the balance between inflammatory- and regulatory T- and B cells determines the AAV disease pathogenesis. Recent evidence shows malfunctioning of the regulatory lymphocyte compartment in AAV. Read More

    The imprint of salivary secretion in autoimmune disorders and related pathological conditions.
    Autoimmun Rev 2018 Feb 9. Epub 2018 Feb 9.
    Department of Pharmacology, Institute of New Drug Development, School of Medicine, Chonbuk National University, Jeonju, Republic of Korea. Electronic address:
    Xerostomia is a state of oral dryness associated with salivary gland dysfunction and is induced by stress, radiation and chemical therapy, various systemic and autoimmune diseases, and specific medications. Fluid secretion is interrupted by the stimulation of neurotransmitter-induced increase in cytosolic calcium ([Ca]) in salivary gland acinar cells, prompting the mobilization of ion channels and their transporters. Salivary fluid and protein secretion are principally dependent on parasympathetic and sympathetic nerves. Read More

    TCRαβCD3CD4CD8(double negative) T cells in autoimmunity.
    Autoimmun Rev 2018 Feb 9. Epub 2018 Feb 9.
    Division of Pediatric Rheumatology and Immunology, Children's Hospital Dresden, Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany; Department of Women's & Children's Health, Institute of Translational Medicine, University of Liverpool, Liverpool, UK; Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust Hospital, Liverpool, UK. Electronic address:
    TCRαβCD3CD4CD8"double negative" (DN) T cells comprise a small subset of mature peripheral T cells. The origin and function of DN T cells are somewhat unclear and discussed controversially. While DN T cells resemble a rare and heterogeneous T cell subpopulation in healthy individuals, numbers of TCRαβDN T cells are expanded in several inflammatory conditions, where they also exhibit distinct effector phenotypes and infiltrate inflamed tissues. Read More

    Nailfold capillaroscopy in systemic lupus erythematosus: A systematic review and critical appraisal.
    Autoimmun Rev 2018 Feb 7. Epub 2018 Feb 7.
    Department of Rheumatology, Ghent University Hospital, De Pintelaan 185, Ghent, Belgium; Department of Internal Medicine, Ghent University, De Pintelaan 185, Ghent, Belgium. Electronic address:
    Nailfold capillaroscopy is an easy, non-invasive technique to assess microvascular involvement in rheumatic diseases. Multiple studies describe capillaroscopic changes in systemic lupus erythematosus (SLE), including a wide range of non-specific findings. On behalf of the European League Against Rheumatism (EULAR) study group on microcirculation in rheumatic diseases, a systematic review was done to obtain all original research studies (in English) in which SLE patients had capillaroscopy. Read More

    Tocilizumab and refractory Takayasu disease: Four case reports and systematic review.
    Autoimmun Rev 2018 Feb 7. Epub 2018 Feb 7.
    Vascular Medicine Division and Regional Competence Centre for Rare Vascular and Systemic Autoimmune Diseases, Hôpitaux de Brabois, CHRU de Nancy, 5 rue du Morvan, 54500 Vandoeuvre-lès-Nancy, France; University of Lorraine, Nancy, France; INSERM UMR_S 1116, Vandoeuvre-lès-Nancy, France. Electronic address:
    Background: Relapses upon corticosteroids tapering and immunosuppressive agents are frequent in Takayasu arteritis (TA). Interleukin-6 is highly involved in physiopathology of TA. Many reports showed efficacy of tocilizumab (TCZ) in refractory TA cases. Read More

    Beyond APECED: An update on the role of the autoimmune regulator gene (AIRE) in physiology and disease.
    Autoimmun Rev 2018 Feb 7. Epub 2018 Feb 7.
    Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA)-I3, Laboratory of Hematology, University of Liège, Liège, Belgium; Center of Excellence for Biomedical Research, University of Genoa Genoa, Italy.
    The autoimmune regulator gene (AIRE) is a transcription factor expressed both in the thymus, by medullary thymic epithelial cells, and in secondary lymphoid organs. AIRE controls the local transcription of organ- specific proteins typically expressed in peripheral tissues, thus allowing the negative selection of self- reactive T cells. The crucial role played by AIRE in central immune tolerance emerged in the studies on the pathogenesis of Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy, a rare inherited polyendocrine/autoimmune disease. Read More

    Comment on the article entitled "Antineutrophil cytoplasmic antibody-associated vasculitides and IgG4-related disease: A new overlap syndrome" (Autoimmunity Reviews 16 (2017) 1036-1043).
    Autoimmun Rev 2018 Feb 8. Epub 2018 Feb 8.
    St Eloi Hospital, Department of Internal Medicine and Multi-organic Diseases, Local Referral Center for Systemic and Autoimmune Diseases, 80 Avenue Augustin Fliche, 34295 Montpellier, France; Montpellier University, Medical School, Montpellier F-34967, France; INSERM U1183, St Eloi Hospital, 80 Avenue Augustin Fliche, 34295 Montpellier, France. Electronic address:

    Contribution of diagnostic tests for the etiological assessment of uveitis, data from the ULISSE study (Uveitis: Clinical and medicoeconomic evaluation of a standardized strategy of the etiological diagnosis).
    Autoimmun Rev 2018 Feb 7. Epub 2018 Feb 7.
    Hospices Civils de Lyon, Croix-Rousse Hospital, Department of Internal Medicine, Lyon, France.
    Purpose: ULISSE is the only study that prospectively assessed the efficiency of a standardized strategy, compared to an open strategy for the etiologic diagnosis of uveitis. Our aim was to evaluate the diagnostic yield of the tests prescribed in the ULISSE study to clarify their relevance.

    Methods: ULISSE is a non-inferiority, prospective, multicenter and cluster randomized study. Read More

    Large-vessel involvement and aortic dilation in giant-cell arteritis. A multicenter study of 549 patients.
    Autoimmun Rev 2018 Feb 7. Epub 2018 Feb 7.
    Department of Internal Medicine, Caen University Hospital, Caen, France; University of Normandy, Caen, France.
    Objectives: Large-vessel involvement (LVI) can occur in giant-cell arteritis (GCA) and may represent a distinct disease subgroup with a higher risk for aortic dilation. This study aimed to better characterize the presentation and evolution of LVI in patients with GCA.

    Patients And Methods: A retrospective multicenter study enrolled 248 GCA patients with LVI and 301 GCA patients without LVI on imaging. Read More

    IgE in lupus pathogenesis: Friends or foes?
    Autoimmun Rev 2018 Feb 7. Epub 2018 Feb 7.
    ImmunoConcEpT, CNRS-UMR 5164 and Université de Bordeaux, 146 rue Léo Saignat, 33076 Bordeaux, France; Centre Hospitalier Universitaire de Bordeaux, FHU ACRONIM, Place Amélie Raba Léon, 33076 Bordeaux, France. Electronic address:
    Systemic lupus erythematosus (SLE) is a complex autoimmune disease involving multiple immunological pathways. Recently, several studies have suggested an implication of Immunoglobulin E (IgE) in the pathophysiology of SLE. In the Lynand FcγIIB. Read More

    Oxidized low density lipoproteins: The bridge between atherosclerosis and autoimmunity. Possible implications in accelerated atherosclerosis and for immune intervention in autoimmune rheumatic disorders.
    Autoimmun Rev 2018 Feb 7. Epub 2018 Feb 7.
    Department of Biomedical Sciences and Human Oncology (DIMO), Systemic Rheumatic and Autoimmune Diseases Unit, University of Bari Medical School, Bari, Italy. Electronic address:
    Atherosclerotic vasculopathy is a multifactorial process causing vessels damage and cardiovascular diseases, the leading causes of death worldwide. Atherosclerotic plaque is the asymptomatic primary, elementary, lesion of atherosclerotic vasculopathy. Accumulation of the oxidized low-density lipoprotein (oxLDL) at sub endothelial sites is now recognized as one of the major trigger events in plaque formation. Read More

    Interaction between microbiome and host genetics in psoriatic arthritis.
    Autoimmun Rev 2018 Feb 1. Epub 2018 Feb 1.
    Rheumatology, Allergology and Clinical Immunology, Department of Medicina dei Sistemi, University of Rome Tor Vergata, Rome, Italy.
    Psoriatic arthritis (PsA) is a chronic inflammatory joint disease, seen in combination with psoriasis. Both genetic and environmental factors are responsible for the development of PsA, however little is known about the different weight of these two distinctive components in the pathogenesis of the disease. Genomic variability in PsA is associated with the disease and/or some peculiar clinical phenotypes. Read More

    Bicaudal D2 is a novel autoantibody target in systemic sclerosis that shares a key epitope with CENP-A but has a distinct clinical phenotype.
    Autoimmun Rev 2018 Jan 31. Epub 2018 Jan 31.
    Department of Medicine, McGill University, Montréal, Quebec, Canada; Division of Rheumatology, Jewish General Hospital, Montréal, Quebec, Canada. Electronic address:
    We studied the clinical correlations and epitopes of autoantibodies directed to a novel autoantigen, Bicaudal D (BICD2), in systemic sclerosis (SSc) and reviewed its relationship to centromere protein A (CENP-A). 451 SSc sera were tested for anti-BICD2 using a paramagnetic bead immunoassay and then univariate and multivariate logistic regression was used to study the association between anti-BICD2 and demographic and clinical parameters as well as other SSc-related autoantibodies. Epitope mapping was performed on solid phase matrices. Read More

    Performance of the 2012 Systemic Lupus International Collaborating Clinics classification criteria versus the 1997 American College of Rheumatology classification criteria in adult and juvenile systemic lupus erythematosus. A systematic review and meta-analysis.
    Autoimmun Rev 2018 Jan 31. Epub 2018 Jan 31.
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands; 1st Medical Department & Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, Hanusch Hospital, Vienna, Austria; Sigmund Freud University, Vienna, Austria. Electronic address:
    Objective: To evaluate the performance in classifying systemic lupus erythematosus by the 2012 Systemic Lupus International Collaborating Clinics criteria (SLICC'12), versus the revised American College of Rheumatology criteria from 1997 (ACR'97) in adult and juvenile SLE patients.

    Methods: A systematic literature search was conducted in PubMed and Embase for studies comparing SLICC'12 and ACR'97 with clinical diagnosis. A meta-analysis was performed to estimate the sensitivity and specificity of SLICC'12 and ACR'97. Read More

    Genetic risk factors in thrombotic primary antiphospholipid syndrome: A systematic review with bioinformatic analyses.
    Autoimmun Rev 2018 Jan 19. Epub 2018 Jan 19.
    Human Genome Centre, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia; School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, 47500 Bandar Sunway, Selangor, Malaysia. Electronic address:
    Background: Antiphospholipid Syndrome (APS) is an autoimmune multifactorial disorder. Genetics is believed to play a contributory role in the pathogenesis of APS, especially in thrombosis development and pregnancy morbidity. In the last 20 years, extensive research on genetic contribution on APS indicates that APS is a polygenic disorder, where a number of genes are involved in the development of its clinical manifestations. Read More

    Vitamin D and juvenile systemic lupus erythematosus: Lights, shadows and still unresolved issues.
    Autoimmun Rev 2018 Jan 22. Epub 2018 Jan 22.
    Institute of Pediatrics, Fondazione Policlinico Universitario "A. Gemelli", Università Cattolica Sacro Cuore, Rome, Italy.
    Systemic lupus erythematosus (SLE) and juvenile SLE (jSLE) are autoimmune disorders naturally associated with several genetic, environmental, hormonal, and immunological contributing factors. It has been assumed that vitamin D deficiency may have a role in the immune activation of patients with SLE and play an active part in many comorbidities and even complications. A host of clinical studies suggested that vitamin D exerts inhibitory effects on many immunological abnormalities associated with SLE, also in children and adolescents, while different reports have hypothesized that vitamin D may be associated with accelerated cardiovascular disease in SLE. Read More

    Cardiovascular involvement in systemic rheumatic diseases: An integrated view for the treating physicians.
    Autoimmun Rev 2018 Jan 29. Epub 2018 Jan 29.
    Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea; Department of Pediatric Nephrology, Severance Children's Hospital, Seoul, Republic of Korea; Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address:
    Systemic autoimmune diseases can affect various kinds of organs including the kidney, the skin, soft tissue and the bone. Among others, cardiovascular involvement in rheumatic diseases has been shown to affect myocardium, pericardium, cardiac vessels, conduction system and valves, eventually leading to increased mortality. In general, underlying chronic inflammation leads to premature atherosclerosis, but also other manifestations such as arrhythmia and heart failure may have a 'silent' progress. Read More

    The anti-inflammatory effects of statins on patients with rheumatoid arthritis: A systemic review and meta-analysis of 15 randomized controlled trials.
    Autoimmun Rev 2018 Jan 17. Epub 2018 Jan 17.
    Tianjin Hospital, No. 406 Jiefang South Rd, Hexi District, Tianjin 300211, China. Electronic address:
    Background: Over the past several years, numerous studies investigated the anti-inflammatory effects of statin on patients with RA. However, the findings of the individual studies were often inconsistent or conflicting.

    Materials And Methods: The Pubmed, Web of Science, Embase, Cochrane Library and CNKI literature databases were searched in order to identify randomized controlled clinical trials where the association between the anti-inflammatory effect of statin and RA was investigated. Read More

    Genetics of immunoglobulin-A vasculitis (Henoch-Schönlein purpura): An updated review.
    Autoimmun Rev 2018 Jan 17. Epub 2018 Jan 17.
    Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain; School of Medicine, University of Cantabria, Santander, Spain; Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Electronic address:
    Immunoglobulin-A vasculitis (IgAV) is classically a childhood small-sized blood vessel vasculitis with predominant involvement of the skin. Gastrointestinal and joint manifestations are common in patients diagnosed with this condition. Nephritis, which is more severe in adults, constitutes the most feared complication of this vasculitis. Read More

    Altered B lymphocyte homeostasis and functions in systemic sclerosis.
    Autoimmun Rev 2018 Jan 16. Epub 2018 Jan 16.
    Univ. Lille, U995, Lille Inflammation Research International Center (LIRIC), F-59000 Lille, France; Inserm, U995, F-59000 Lille, France; CHU Lille, Institut d'immunologie, F-59000 Lille, France.
    Beyond the production of autoantibodies, B-cells are thought to play a role in systemic sclerosis (SSc) by secreting proinflammatory/profibrotic cytokines. B-cells are a heterogeneous population with different subsets distinguished by their phenotypes and cytokine production. Data about B-cell subsets, cytokine production and intracellular pathways leading to this production are scarce in SSc. Read More

    Rheumatic manifestations among cancer patients treated with immune checkpoint inhibitors.
    Autoimmun Rev 2018 Jan 16. Epub 2018 Jan 16.
    Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Ella Lemelbaum Institute for Immuno-Oncology, Sheba Medical Center, Israel. Electronic address:
    Background: The use of immune checkpoint inhibitors (ICI) has grown incessantly since they were first approved in 2014. These monoclonal antibodies inhibit T cell activation, yielding a dramatic tumor response with improved survival. However, immunotherapy is frequently hampered by immune adverse events (iAE) such as hypophysitis, colitis, hepatitis, pneumonitis and rash. Read More

    Arterial stenosis in antiphospholipid syndrome: Update on the unrevealed mechanisms of an endothelial disease.
    Autoimmun Rev 2018 Jan 16. Epub 2018 Jan 16.
    Division of Rheumatology, Department of Internal Medicine, Dubai Hospital, United Arab Emirates.
    First described in 1983, antiphospholipid syndrome (APS) is an autoimmune condition characterized by the occurrence of recurrent arterial and/or venous thrombosis, and/or pregnancy morbidity, in the setting of persistent presence of antiphospholipid antibodies (aPL). While thrombosis is the most well-known pathogenic mechanism in this disorder, the relevance of some other mechanisms such as arterial stenosis is being increasingly recognized. Arterial stenosis has been first described in the renal arteries in patients with APS, however intracranial and coeliac arteries can also be involved with various and treatable clinical manifestations. Read More

    Diagnosis and management of neuromyelitis optica spectrum disorders - An update.
    Autoimmun Rev 2018 Jan 13. Epub 2018 Jan 13.
    Department of Sense Organs, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy. Electronic address:
    Neuromyelitis optica (NMO) and Neuromyelitis optica spectrum disorders (NMOSD) are a group of autoimmune conditions characterized by inflammatory involvement of the optic nerve, spinal cord and central nervous system. Novel evidence showed a key role of autoantibodies against aquaporin-4 immunoglobulin G (AQP4 IgG) in the pathogenesis of NMOSD and, recently, new classification and diagnostic criteria have been adopted to facilitate an earlier identification and improve the management of these conditions. Diagnosis of NMOSD is currently based on clinical, neuroimaging and laboratory features. Read More

    Imaging modalities for the diagnosis and disease activity assessment of Takayasu's arteritis: A systematic review and meta-analysis.
    Autoimmun Rev 2018 Feb 5;17(2):175-187. Epub 2017 Dec 5.
    Division of Rheumatology, Department of Medicine, Mount Sinai Hospital, 60 Murray St., Toronto, Ontario M5T 3L9, Canada.
    Background: Early diagnosis of Takayasu's Arteritis (TAK) and detection of disease activity may reduce the risk of vascular complications. The objective of this study was to determine the effectiveness of imaging modalities for the management of TAK.

    Methods: MEDLINE and EMBASE were searched for studies of patients undergoing various imaging modalities for TAK diagnosis or to assess disease activity. Read More

    Pitfalls in the detection of citrullination and carbamylation.
    Autoimmun Rev 2018 Feb 2;17(2):136-141. Epub 2017 Dec 2.
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.
    Carbamylation and citrullination are both post-translational modifications against which (auto)antibodies can be detected in sera of rheumatoid arthritis (RA) patients. Carbamylation is the chemical modification of a lysine into a homocitrulline, whereas citrullination is an enzymatic conversion of an arginine into a citrulline. It is difficult to distinguish between the two resulting amino acids due to similarities in structure. Read More

    A concise review of significantly modified serological biomarkers in giant cell arteritis, as detected by different methods.
    Autoimmun Rev 2018 Feb 28;17(2):188-194. Epub 2017 Nov 28.
    Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana SI-1000, Slovenia.
    Giant cell arteritis (GCA) is a primary systemic vasculitis present in subjects older than 50years with involvement of large- and medium-sized arteries. Early diagnosis for GCA is essential to prevent serious complications, such as permanent vision loss and/or cerebrovascular events. Elevated inflammatory cytokines, with acute phase and other proteins dominate large- and medium-sized arteries leading to stenosis or occlusion of arterial lumen. Read More

    Clinical and immunological aspects of anti-peptidylarginine deiminase type 4 (anti-PAD4) autoantibodies in rheumatoid arthritis.
    Autoimmun Rev 2018 Feb 2;17(2):94-102. Epub 2017 Dec 2.
    Department of Molecular Biology and Genomics, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Jalisco, Mexico.
    Rheumatoid arthritis (RA) is the most common rheumatic autoimmune disease worldwide, which causes progressive joint damage and can lead to functional disability. Despite prominent advances in RA diagnosis and treatment during the last 20years, there is still a need for novel biomarkers that aid in diagnosis and prognosis of this heterogeneous disease. Citrullination is a key post-translational modification implicated on anti-citrullinated protein/peptide antibodies (ACPA) production in RA, catalyzed by human peptidylarginine deiminases (PADs). Read More

    Imaging aspects of interstitial lung disease in patients with rheumatoid arthritis: Literature review.
    Autoimmun Rev 2018 Feb 28;17(2):87-93. Epub 2017 Nov 28.
    Pulmonary Institute, Rambam Health Care Campus, Israel; Rappaport Faculty of Medicine-Technion, Israeli Institute of Technology, Haifa, Israel.
    Objective: Interstitial lung disease (ILD) is a frequent and severe complication of rheumatoid arthritis (RA), resulting in pulmonary fibrosis (PF) and respiratory failure.

    Methods: Chest computed tomography (CT-c) or high resolution CT (HRCT) is the main modality for assessment of ILD. We performed a systematic literature review on CT-c/HRCT findings in patients with ILD-RA, using the MEDLINE database for the period from 1991 to 2015. Read More

    Scleroderma skin ulcers definition, classification and treatment strategies our experience and review of the literature.
    Autoimmun Rev 2018 Feb 2;17(2):155-164. Epub 2017 Dec 2.
    Chair and Rheumatology Unit, University of Modena and Reggio Emilia, Medical School, Azienda Ospedaliero-Universitaria, Policlinico di Modena, Modena, Italy. Electronic address:
    Background: Skin ulcers (SU) are one of the most frequent manifestations of systemic sclerosis (SSc). SSc-SU are very painful, often persistent and recurrent; they may lead to marked impairment of patient's activities and quality of life. Despite their severe impact on the whole SSc patient's management, the proposed definition, classification criteria, and therapeutic strategies of SSc-SU are still controversial. Read More

    Combined therapies to treat complex diseases: The role of the gut microbiota in multiple sclerosis.
    Autoimmun Rev 2018 Feb 28;17(2):165-174. Epub 2017 Nov 28.
    Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya, Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain; Universitat Autònoma de Barcelona, 08193, Bellaterra, Cerdanyola del Vallès, Spain. Electronic address:
    The commensal microbiota has emerged as an environmental risk factor for multiple sclerosis (MS). Studies in experimental autoimmune encephalomyelitis (EAE) models have shown that the commensal microbiota is an essential player in triggering autoimmune demyelination. Likewise, the commensal microbiota modulates the host immune system, alters the integrity and function of biological barriers and has a direct effect on several types of central nervous system (CNS)-resident cells. Read More

    Curcumin: A natural modulator of immune cells in systemic lupus erythematosus.
    Autoimmun Rev 2018 Feb 24;17(2):125-135. Epub 2017 Nov 24.
    Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:
    Curcumin is a polyphenol natural product isolated from turmeric, interacting with different cellular and molecular targets and, consequently, showing a wide range of pharmacological effects. Recent preclinical and clinical trials have revealed immunomodulatory properties of curcumin that arise from its effects on immune cells and mediators involved in the immune response, such as various T-lymphocyte subsets and dendritic cells, as well as different inflammatory cytokines. Systemic lupus erythematosus (SLE) is an inflammatory, chronic autoimmune-mediated disease characterized by the presence of autoantibodies, deposition of immune complexes in various organs, recruitment of autoreactive and inflammatory T cells, and excessive levels of plasma proinflammatory cytokines. Read More

    Belimumab in the treatment of systemic lupus erythematous: An evidence based review of its place in therapy.
    Autoimmun Rev 2018 Feb 24;17(2):103-107. Epub 2017 Nov 24.
    Hospital Israelita Albert Einstein, São Paulo, Brazil. Electronic address:
    Introduction: Systemic lupus erythematous is an autoimmune disease with diverse clinical features and has its development associated with a complexity of genetic, hormonal and environmental factors and the development of autoantibodies. Identification of new treatments is currently an area of intense investigation. Belimumab is the first biologic approved for the treatment of the disease inhibiting the excessive B cell activity observed in these patients and consequently reduction of autoantibodies. Read More

    Clinical and microbiological characteristics of the infections in patients treated with rituximab for autoimmune and/or malignant hematological disorders.
    Autoimmun Rev 2018 Feb 24;17(2):115-124. Epub 2017 Nov 24.
    Internal Medicine and Multi-organic Diseases Department, Local Referral Center for Rare Autoimmune Diseases, Montpellier University Hospital, Montpellier F-34000, France; Institut National de la Santé Et de la Rercherche Médicale (INSERM) U1183, Institute for Regenerative Medicine and Biotherapies (IRMB), Montpellier F-34000, France. Electronic address:
    Introduction: Rituximab is commonly used for the treatment of hematological malignancies and autoimmune diseases. Despite a reputation for good tolerance, case-series and registries reported rituximab-related infections of variable severity including opportunistic infections. We aimed at describing the natural history of infectious events (IE) after treatment by rituximab providing clinical and microbiological features and outcome. Read More

    NK cells in autoimmune diseases: Linking innate and adaptive immune responses.
    Autoimmun Rev 2018 Feb 26;17(2):142-154. Epub 2017 Nov 26.
    Type 1 Diabetes Centre, Infectivology and Clinical Trials Research Department, Children's Hospital Bambino Gesù, Rome, Italy. Electronic address:
    The pathogenesis of autoimmunity remains to be fully elucidated, although the contribution of genetic and environmental factors is generally recognized. Despite autoimmune conditions are principally due to T and B lymphocytes, NK cells also appear to play a role in the promotion and/or maintenance of altered adaptive immune responses or in peripheral tolerance mechanisms. Although NK cells are components of the innate immune system, they shows characteristics of the adaptive immune system, such as the expansion of pathogen-specific cells, the generation of long-lasting "memory" cells able to persist upon cognate antigen encounter, and the possibility to induce an increased secondary recall response to re-challenge. Read More

    Childhood- versus adult-onset ANCA-associated vasculitides: A nested, matched case-control study from the French Vasculitis Study Group Registry.
    Autoimmun Rev 2018 Feb 24;17(2):108-114. Epub 2017 Nov 24.
    National Referral Center for Rare Systemic Autoimmune Diseases, Department of Internal Medicine, Hôpital Cochin, Assistance Publique - Hôpitaux de Paris (APHP), Paris, France; Université Paris Descartes, Paris, France. Electronic address:
    Objective: To investigate differences between childhood-onset ANCA-associated vasculitides (cAAVs) and matched adult-onset controls (aAAVs).

    Methods: cAAV clinical pictures at onset and outcomes were compared to a randomly selected sample of aAAV patients from the French Vasculitis Study Group Registry. Cases and controls were matched for AAV (granulomatosis with polyangiitis [GPA], microscopic polyangiitis [MPA] or eosinophilic granulomatosis with polyangiitis [EGPA]), sex and year of enrollment. Read More

    Are the ACR 2010 diagnostic criteria for fibromyalgia better than the 1990 criteria?
    Autoimmun Rev 2018 Jan 3;17(1):33-35. Epub 2017 Nov 3.
    CREATE Centre, Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, Wales, UK. Electronic address:
    Fibromyalgia (FM) is difficult to diagnose and manage chronic pain condition whose symptoms have no clear pathophysiological cause, although it is thought that patient hypersensitivity to a range of stimuli may give rise to mechanical hyperalgesia as a result of altered central nociceptive processing. The 1990 American College of Rheumatology (ACR) classification criteria, which have been widely used in clinical practice, require the existence of chronic widespread pain (CWP) for >3months, and the presence of at least 11 out of 18 specified tender points upon digital palpation, although this latter criterion has long been criticised. The newer 2010 ACR diagnostic criteria state that FM can be defined as CWP associated with somatic symptoms, and recommend the use of a widespread pain index and a scale to rate symptom severity. Read More

    Vitamin D and systemic lupus erythematosus - The hype and the hope.
    Autoimmun Rev 2018 Jan 3;17(1):19-23. Epub 2017 Nov 3.
    Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Faculty of Biology Medicine and Health, The University of Manchester, UK; NIHR Manchester Biomedical Research Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
    Over the past 20years, much has been written about the potential role of vitamin D in on adverse health outcomes. In recent years, evidence has accumulated regarding the effect of vitamin D on the immune system, and its different cells. Some studies have noted lower vitamin D concentrations in patients with SLE. Read More

    TNF inhibitors in rheumatoid arthritis and spondyloarthritis: Are they the same?
    Autoimmun Rev 2018 Jan 3;17(1):24-28. Epub 2017 Nov 3.
    Rheumatology Unit, ASST Fatebenefratelli Sacco, Milan, Italy, Milan, Italy.
    The advent of anti-tumour necrosis factor (TNF) drugs for rheumatoid arthritis (RA) or spondyloarthritis (SpA) has revolutionised the approach to patients with active disease who do not respond to conventional therapy. Although there are differences in their structure, morphology, pharmacokinetic properties and activity, all anti-TNF drugs ultimately neutralise the TNFα pathway of inflammation. However, despite their similar clinical efficacy, there are disagreements concerning drug survival and safety, with systematic reviews and meta-analyses confirming one result or the other. Read More

    Can we manage lupus nephritis without chronic corticosteroids administration?
    Autoimmun Rev 2018 Jan 3;17(1):4-10. Epub 2017 Nov 3.
    Division of Nephrology, Department of Medicine, University Health Network, Toronto, Canada.
    The outcome of lupus nephritis (LN) has changed since the introduction of glucocorticoids (GCs), which dramatically reduced the mortality related to one of the most severe complications of systemic lupus erythematosus (SLE). Since the 1950's, other immunosuppressants, including biologic drugs (i.e. Read More

    Physical activity and autoimmune diseases: Get moving and manage the disease.
    Autoimmun Rev 2018 Jan 3;17(1):53-72. Epub 2017 Nov 3.
    Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Electronic address:
    Physical activity, by definition, is any skeletal muscle body movement that results in energy expenditure. In the last few decades, a plethora of scientific evidences have accumulated and confirmed the beneficial role of physical activity as a modifiable risk factor for a wide variety of chronic diseases including cardiovascular diseases (CVDs), diabetes mellitus and cancer, among others. Autoimmune diseases are a heterogeneous group of chronic diseases, which occur secondary to loss of self-antigen tolerance. Read More

    Targeting interferons and their pathways in systemic lupus erythematosus.
    Autoimmun Rev 2018 Jan 4;17(1):44-52. Epub 2017 Nov 4.
    Service de rhumatologie, Centre National de Référence des Maladies Autoimmunes et Systémiques Rares, Université de Strasbourg, INSERM UMR-S 1109, F-67000 Strasbourg, France. Electronic address:
    Significant advances in the understanding of the molecular basis of innate immunity have led to the identification of interferons (IFNs), particularly IFN-α, as central mediators in the pathogenesis of Systemic Lupus Erythematosus. Therefore, targeting of IFNs and of their downstream pathways has emerged as important developments for novel drug research in SLE. Based on this, several specific interferon blocking strategies using anti-IFN-α antibodies, anti-type I interferon receptor antibodies, Interferon-α-kinoid, or anti-IFN-γ antibodies have all been assessed in recent clinical trials. Read More

    Can we withdraw immunosuppressants in patients with lupus nephritis in remission? An expert debate.
    Autoimmun Rev 2018 Jan 3;17(1):11-18. Epub 2017 Nov 3.
    Joint Rheumatology Program, 4th Department of Medicine, "Attikon" University Hospital, National and Kapodistrian University of Athens Medical School and Biomedical Research Foundation of the Athens Academy, Athens, Greece; Medical School, University of Cyprus, Nicosia, Cyprus. Electronic address:
    Lupus nephritis (LN) treatment requires an initial intensive period of therapy followed by a long-term maintenance treatment in order to stabilize disease control and eventually reach renal remission. In this section, Authors discuss the feasibility of safely lowering and even suspending maintenance therapy in LN patients having entered remission, highlighting hurdles in predicting the depth and durability of disease quiescence together with the need for minimizing potentially toxic therapies. Even though no firm conclusions can still be drawn, the treating physician has to find the wise balance between disease control and treatment-related drawbacks by following patients closely and recognizing as early as possible the ones who are likely to reach a deep and durable renal remission; there is consensus that is these are the only patients in whom a potential safe complete withdrawal can be foreseen so far. Read More

    Cocaine and ANCA associated vasculitis-like syndromes - A case series.
    Autoimmun Rev 2018 Jan 3;17(1):73-77. Epub 2017 Nov 3.
    Department of Rheumatology and Lupus, Guy's and St. Thomas' NHS Foundation Trust, London, UK. Electronic address:
    Objectives: We analysed the spectrum of clinical manifestations of cocaine associated pseudovasculitis.

    Methods: Clinical, serological, radiological and histological features of 14 patients with cocaine pseudovasculitis syndromes were included.

    Results: Twelve patients had significant sinus thickening or erosive disease. Read More

    The immunobiology and clinical features of type 1 autoimmune polyglandular syndrome (APS-1).
    Autoimmun Rev 2018 Jan 4;17(1):78-85. Epub 2017 Nov 4.
    Division of Rheumatology, Allergy and Clinical Immunology, School of Medicine, University of California, Davis, CA 95616, USA. Electronic address:
    Autoimmune Polyglandular Syndrome type 1 (APS-1) is a subtype of the autoimmune polyendocrine syndrome characterized by the simultaneous or sequential dysfunction of multiple endocrine or non-endocrine glands. A clinical diagnosis of APS-1 is typically based on the presence of at least two of three following criteria: chronic mucocutaneous candidiasis, hypoparathyroidism and adrenal insufficiency. The first identified causative mutated gene for APS-1 is autoimmune regulator (AIRE) encoding a critical transcription factor, which is primarily expressed in the medullary thymic epithelial cells (mTECs) for generating central immune tolerance. Read More

    Brain diffusion tensor MRI in systematic lupus erythematosus: A systematic review.
    Autoimmun Rev 2018 Jan 3;17(1):36-43. Epub 2017 Nov 3.
    Laboratory of Autoimmune Disease, State University of Campinas (UNICAMP), Brazil; Rheumatology Unit, Department of Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Brazil. Electronic address:
    Diffusion tensor imaging (DTI) maps the brain's microstructure by measuring fractional anisotropy (FA) and mean diffusivity (MD). This systematic review describes brain diffusion tensor Magnetic resonance imaging (MRI) studies in systemic lupus erythematosus (SLE).The literature was reviewed following the PRISMA guidelines and using the terms "lupus", "systemic lupus erythematosus", "SLE", "diffusion tensor imaging", "DTI", "white matter" (WM), "microstructural damage", "tractography", and "fractional anisotropy"; the search included articles published in English from January 2007 to April 2017. Read More

    Is undifferentiated spondyloarthritis a discrete entity? A debate.
    Autoimmun Rev 2018 Jan 3;17(1):29-32. Epub 2017 Nov 3.
    Rheumazentrum Ruhrgebiet, Herne, Ruhr-University Bochum, Germany.
    The concept of undifferentiated spondyloarthritis has been introduced recently to describe a clinical setting where the classical features of spondyloarthritis (SpA) are not fully present. Whether this is a discrete entity was the basis of a debate during the 4th International Congress on Controversies in Rheumatology & Autoimmunity held in Bologna, Italy 9-11 March 2017. The pro and con aspects of the debate are presented. Read More

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