2,543 results match your criteria Autoimmunity[Journal]

The prevalence and role of functional autoantibodies to angiotensin-converting-enzyme-2 in patients with systemic sclerosis.

Autoimmunity 2021 Apr 29:1-6. Epub 2021 Apr 29.

Department of Dermatology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.

Introduction: Systemic sclerosis (SSc) is an autoimmune disease caused by the imbalance between the activity of angiotensin II and angiotensin-(1-7). Their balance should be controlled by angiotensin-converting enzyme 2 (ACE2), which degrades angiotensin II into angiotensin-(1-7). Previously, autoantibodies to ACE2 (anti-ACE2) were identified in patients with vasculopathy due to different connective tissue diseases, including SSc, but their frequency in SSc was not further analyzed. Read More

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SChLAP1 contributes to non-small cell lung cancer cell progression and immune evasion through regulating the AUF1/PD-L1 axis.

Autoimmunity 2021 Apr 27:1-9. Epub 2021 Apr 27.

Department of Cancer Center, Weifang Hospital of Traditional Chinese Medicine (TCM), Weifang, China.

SChLAP1 is recently reported as a key oncogenic long non-coding RNA in human cancer. However, whether SChLAP1 functions in non-small cell lung cancer (NSCLC) and its specific potential regulatory mechanism remain unexplored. In this study, we found that depletion of SChLAP1 significantly inhibited NSCLC cell proliferation, migration and invasion , and retarded tumour growth and lung metastasis . Read More

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COVID-19: captures iron and generates reactive oxygen species to damage the human immune system.

Autoimmunity 2021 Apr 26:1-12. Epub 2021 Apr 26.

School of Life Science and Food Engineering, Yibin University, Yibin, China.

Currently, the novel coronavirus pneumonia has been widespread globally, and there is no specific medicine. In response to the emergency, we employed bioinformatics methods to investigate the virus's pathogenic mechanism, finding possible control methods. We speculated in previous studies that E protein was associated with viral infectivity. Read More

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The utility of immunoglobulin A/complement 3 and immunoglobulin G/immunoglobulin M ratios in the assessment of disease activation in patients with Behçet disease.

Autoimmunity 2021 May 9;54(3):176-180. Epub 2021 Apr 9.

Department of Dermatology and Veneorology, Ufuk University, Ankara, Turkey.

Objective: Pathogenesis of Behçet disease (BD) has not yet been clearly revealed and there is no ideal test for the estimation of disease activation at present. This study aimed to assess the efficiencies of IgG/IgM and IgA/C3 ratios in determining activation of BD.

Method: This retrospective cohort study consisted of 140 patients with BD. Read More

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The lncRNA PVT1/miR-590-5p/FSTL1 axis modulates the proliferation and migration of airway smooth muscle cells in asthma.

Autoimmunity 2021 May 7;54(3):138-147. Epub 2021 Apr 7.

Department of Pediatrics, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, P.R. China.

Objective: Asthma is a prevalent chronic inflammatory airway disease that is characterised by airway remodelling and airway hyperresponsiveness. Abnormal proliferation and migration of airway smooth muscle cells (ASMCs) contribute to airway remodelling in asthma. However, the molecular mechanism underlying an increased ASMC mass in asthma remains elusive. Read More

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Autoantibody profiles in systemic sclerosis; a comparison of diagnostic tests.

Autoimmunity 2021 May 5;54(3):148-155. Epub 2021 Apr 5.

Laboratory for Medical Immunology, Radboud University Medical Center, Nijmegen, The Netherlands.

Objectives: Autoimmune antibody profiling plays a prominent role in both classification and prognosis of systemic sclerosis (SSc). In the last years novel autoantibodies have been discovered and have become available in diagnostic assays. However, standardization in autoimmune serology is lacking, which may have a negative impact on the added value of autoantibodies in diagnosis and prognosis of SSc. Read More

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Progesterone decreased indoleamine 2,3-dioxygenase 1(IDO1) expression in early pregnancy chorionic villi and decidua.

Autoimmunity 2021 May 1;54(3):156-162. Epub 2021 Apr 1.

Guizhou Provincial People's Hospital, Guiyang, China.

Indoleamine 2,3-dioxygenase1(IDO1) is one of the most important proteins in protect the embryos from the mother's immune system during pregnancy. However, the regulation of the protein expression at the maternal-foetal interface is not fully known. We aimed to study the regulation of IDO1 expression by progesterone in villi and decidua of in early pregnancy. Read More

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LncRNA NORAD engages in psoriasis by binding to miR-26a to regulate keratinocyte proliferation.

Autoimmunity 2021 May 24;54(3):129-137. Epub 2021 Mar 24.

Department of Dermatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Background: Psoriasis is a chronic, inflammatory skin disease. It was reported that lncRNA Non-coding RNA-activated by DNA damage (NORAD) has potential regulatory effects on skin diseases. Our previous studies found that lncRNA NORAD was highly expressed and its potential target miR-26a was down-regulated in psoriasis model mice. Read More

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The role of neuraminidase 1 (NEU1) in cytokine release by primary mouse mesangial cells and disease outcomes in murine lupus nephritis.

Autoimmunity 2021 May 22;54(3):163-175. Epub 2021 Mar 22.

Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, USA.

The importance of altered glycosphingolipid (GSL) metabolism is increasingly gaining attention as a characteristic of multiple chronic kidney diseases. Previously, we reported elevated levels of GSLs and neuraminidase (NEU) enzyme activity/expression in the urine or kidney of lupus patients and lupus-prone mice, and demonstrated NEU activity mediates the production of cytokines by lupus-prone mouse primary mesangial cells. This mediation occurs in part through TLR4 and p38/ERK MAPK signalling in response to lipopolysaccharide (LPS) and lupus serum (LS). Read More

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LncRNA NEAT1 activates MyD88/NF-κB pathway in bronchopneumonia through targeting miR-155-5p.

Autoimmunity 2021 Mar 9;54(2):104-113. Epub 2021 Mar 9.

Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Hunan Normal University, Hunan Provincial People's Hospital, Changsha, P. R. China.

Background: Bronchopneumonia is a disease of the respiratory tract. It leads to other complications and endangers life and health. Long non-coding RNA (lncRNA) participates in the occurrence and development of bronchopneumonia. Read More

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Hsa_circ_0056558 regulates cyclin-dependent kinase 6 by sponging microRNA-1290 to suppress the proliferation and differentiation in ankylosing spondylitis.

Autoimmunity 2021 Mar 9;54(2):114-128. Epub 2021 Mar 9.

Rheumatology and Immunology Department, The Second People's Hospital of Liaocheng, The Second Hospital of Liaocheng Affiliated to Shandong First Medical University, Linqing, P.R. China.

The aims of this study was to investigate the influences of hsa_circ_0056558/miR-1290/CDK6 axis in ankylosing spondylitis (AS). The differentially expressed has_circ_0056558 and miR-1290 in AS tissue were analysed based on RNA-seq data and microarray data, respectively. qRT-PCR was performed for detection of relative expression levels of hsa_circ_0056558, miR-1290, CDK6, osteogenic differentiation markers (Runx2 and Osterix) and other inflammatory factors (TNF-α, IL-1β, and IL-6). Read More

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Immune repertoire: Revealing the "real-time" adaptive immune response in autoimmune diseases.

Autoimmunity 2021 Mar 2;54(2):61-75. Epub 2021 Mar 2.

Department of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, Hunan, China.

The diversity of the immune repertoire (IR) enables the human immune system to distinguish multifarious antigens (Ags) that humans may encounter throughout life. At the same time, bias or abnormalities in the IR also pay a contribution to the pathogenesis of autoimmune diseases. Rapid advancements in high-throughput sequencing (HTS) technology have ushered in a new era of immune studies, revealing novel molecules and pathways that might result in autoimmunity. Read More

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Elevated soluble Tim-3 correlates with disease activity of systemic lupus erythematosus.

Autoimmunity 2021 Mar 1;54(2):97-103. Epub 2021 Mar 1.

Department of Clinical laboratory, Qilu Hospital of Shandong University, Ji'nan, China.

T cell immunoglobulin and mucin domain-containing molecule-3(Tim-3) has been found to play important roles in systemic lupus erythematosus (SLE), but whether sTim-3 is involved in the development of SLE remains unknown. In this study, we firstly observed an increased expression of plasma sTim-3 in SLE patients, especially active SLE patients. The plasma sTim-3 levels were positively correlated with anti-dsDNA, SLEDAI score, ESR, and urine albumin. Read More

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LncRNA SNHG5 promotes cervical cancer progression by regulating the miR-132/SOX4 pathway.

Autoimmunity 2021 Mar 23;54(2):88-96. Epub 2021 Feb 23.

Department of Laboratory, Hangzhou Jianggan District People's Hospital, Hangzhou, China.

Background: The long non-coding RNA (lncRNA) small nucleolar RNA host gene 5 (SNHG5) has been verified as a crucial regulator in many types of tumours but not clear in cervical cancer (CC). This study aims to investigate the effect and further mechanisms of lncRNA SNHG5 in CC.

Methods: The expression of SNHG5 and miR-132, as well as SOX4 (sex-determining region Y-box 4) mRNA expression were determined by quantitative real-time PCR (qRT-PCR). Read More

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Identification of ANXA1 as a potential prognostic biomarker and correlating with immune infiltrates in colorectal cancer.

Autoimmunity 2021 Mar 18;54(2):76-87. Epub 2021 Feb 18.

Department of Pharmacy, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.

Background: ANXA1 is a calcium-dependent phospholipid-binding protein and is frequently associated with inflammation, cell proliferation and apoptosis. However, the relationship between ANXA1 and the prognosis of multiple tumours and tumour infiltrating immune cells remains unclear.

Methods: Multivariate Cox proportional regression analysis was used for signature genes exploration in the basic of colon adenocarcinoma (COAD) RNA-sequence dataset obtained from TCGA, following the identification of 267 common differentially expressed genes, including ANXA1, among three expression profile datasets (GSE41328, GSE110224, and GSE113513). Read More

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Differential synovial tissue expression of TLRs in seropositive and seronegative rheumatoid arthritis: A preliminary report.

Autoimmunity 2021 02 30;54(1):23-34. Epub 2020 Dec 30.

Anatomy and Cell Biology, Medical Research Center Oulu and Cancer and Translational Medicine Research Unit, Oulu University Hospital and University of Oulu, Oulu, Finland.

Toll-like receptors (TLRs) are known to have an important role in triggering the innate immune response and in priming antigen-specific adaptive immunity and inflammation. The differences in synovial tissue expression of the TLRs between seronegative and seropositive rheumatoid arthritis (RA) were examined from 9 seropositive RA, 5 seronegative RA and 4 osteoarthritis (OA) patients. Synovitis status was assessed using Krenn's scoring and TLR 1-9 expression by immunohistochemistry. Read More

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February 2021

Dioscin alleviates hashimoto's thyroiditis by regulating the SUMOylation of IRF4 to promote CD4CD25Foxp3 treg cell differentiation.

Autoimmunity 2021 02 4;54(1):51-59. Epub 2020 Dec 4.

The No. 1 Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, Kunming, China.

Dioscin has been used as a treatment for Hashimoto's thyroiditis (HT) in China. However, the molecular mechanisms governing the modes of action of dioscin have not been elucidated. In this study, flow cytometry and Western blotting were used to identify the proportions of CD4CD25 regulatory T (Treg) cells and the expression of forkhead box P3 (Foxp3) and SUMO-specific protease 1 (SENP1) in HT patients' peripheral blood mononuclear cells (PBMCs). Read More

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February 2021

IgA autoantibodies directed against self DNA are elevated in cystic fibrosis and associated with more severe lung dysfunction.

Autoimmunity 2020 12;53(8):476-484

Department of Infectious Diseases, College of Veterinary Medicine, The University of Georgia, Athens, GA, USA.

Although extracellular host DNA (ecDNA) levels in CF airways were linked to airflow obstruction and recombinant DNAse therapy is beneficial for CF patients, it remains incompletely understood whether ecDNA also leads to an autoimmune response. Here we hypothesized that chronic presence of DNA in CF airways triggers the production of autoantibodies targeting host human DNA. We measured the levels of IgA autoantibodies recognising host double-stranded (ds) DNA in the blood and sputum samples of CF patients and only sera of controls subjects and patients suffering from rheumatoid arthritis and systemic lupus erythematosus (SLE) that served as non-CF, autoimmune disease cohorts. Read More

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December 2020

Evaluation of the diagnostic performance of an immunoblot for ANCA and anti-GBM antibody detection.

Autoimmunity 2021 02 20;54(1):45-50. Epub 2020 Nov 20.

Central Diagnostic Laboratory, Maastricht University Medical Center, Maastricht, The Netherlands.

The use of high-quality antigen-specific immunoassays for detecting anti-neutrophil cytoplasmic antibodies (ANCA) and anti-glomerular basement membrane (GBM) autoantibodies is recommended in patients with suspected ANCA vasculitis and/or anti-GBM disease. We analysed the diagnostic performance of a semi-quantitative and rapid immunoblot (EUROIMMUN AG, Lübeck, Germany) in two settings. Patient sera from different cohorts (ANCA vasculitis  = 187, anti-GBM disease  = 19, and disease controls  = 51) were used. Read More

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February 2021

LncRNA alleviates rheumatoid arthritis through regulating miR-222-3p/Sirt1 signalling axis.

Autoimmunity 2021 02 20;54(1):13-22. Epub 2020 Nov 20.

Department of Rheumatology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, P. R. China.

Introduction: Rheumatoid arthritis (RA) is an autoimmune disease that affects millions of people. Fibroblast-like synoviocytes (FLSs) located in rheumatoid panni play a pivotal role in the formation of RA. The long noncoding RNA (lncRNA) is reportedly downregulated in rheumatoid arthritis. Read More

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February 2021

Differential mitochondrial genome in patients with Rheumatoid Arthritis.

Autoimmunity 2021 02 15;54(1):1-12. Epub 2020 Nov 15.

Disease Biology Laboratory, School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT), Deemed to be University, Bhubaneswar, India.

Background: Mitochondria play an important role in cell survival, function and lineage differentiation. Changes in mitochondrial DNA (mtDNA) may control mitochondrial functions and thus may impart an alternative cellular state thereby leading to a disease condition in the body. Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease wherein immune cells become self-reactive causing joint inflammation, swelling and pain in patients. Read More

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February 2021

Nanostructured lipid carrier-based smart gel: a delivery platform for intra-articular therapeutics.

Autoimmunity 2021 02 12;54(1):35-44. Epub 2020 Nov 12.

Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, India.

The promising potential of nano-structured lipid carrier (NLC) polymeric gel of CUR as an effective treatment for rheumatoid arthritis by intra-articular route of administration was investigated. NLC composed of cetylpalmitate, Labrafac PG & Captex 200, Tween 80 and Labrasol. The hot homogenization method employed by melt ultrasonication was used. Read More

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February 2021

LncRNA TUG1 positively regulates osteoclast differentiation by targeting v-maf musculoaponeurotic fibrosarcoma oncogene homolog B.

Autoimmunity 2020 12 4;53(8):443-449. Epub 2020 Nov 4.

Department of Oral Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Osteoclast differentiation-mediates bone resorption is the key biological basis of orthodontic treatment while the specific mechanism of osteoclastogenesis remains unclear. This study aims to explore the underlying mechanism of the osteoclast differentiation from the perspective of long non-coding RNA (LncRNA). In the present study, the osteoclast differentiation of CD14 peripheral blood mononuclear cells (PBMCs) was induced by recombinant human macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor κB ligand (RANKL), and LncRNA TUG1 expression was dramatically elevated during this process. Read More

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December 2020

Autoimmune response against tyrosinase induces depigmentation in C57BL/6 black mice.

Autoimmunity 2020 12 21;53(8):459-466. Epub 2020 Oct 21.

Department of Medical Biochemistry, College of Medicine, Qassim University, Buraidah, Saudi Arabia.

Regulation of melanogenesis by tyrosinase has now become an attractive approach for treatment of vitiligo but still the role of tyrosinase in the induction of depigmentation remains largely unexplored. This study was explored the role of tyrosinase in the induction of autoimmune depigmentation in C57BL/6 mice. Depigmentation was induced in C57BL/6 mice by tyrosinase immunization. Read More

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December 2020

Icariin alleviates rheumatoid arthritis via regulating miR-223-3p/NLRP3 signalling axis.

Autoimmunity 2020 12 21;53(8):450-458. Epub 2020 Oct 21.

Department of Traditional Chinese Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, PR China.

Rheumatoid arthritis (RA) is considered to be a chronic autoimmune disease, pathogenesis of RA is complex and effective treatments for RA is still lacking. Previous studies found that microRNAs (miRNAs) play important roles in the pathogenesis of RA, and miR-223-3p is considered to be one of the possible biomarkers of RA. Recent studies have revealed that icariin alleviates RA in murine models, but the underlying mechanism needs to be further investigated. Read More

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December 2020

DL-propargylglycine administration inhibits TET2 and FOXP3 expression and alleviates symptoms of neonatal Cows' milk allergy in mouse model.

Autoimmunity 2020 12 20;53(8):467-475. Epub 2020 Oct 20.

Department of Gastroenterology, Xuzhou Children's Hospital, Xuzhou Medical University, Xuzhou, China.

Background: Cows' milk allergy (CMA) is a hypersensitivity immune reaction brought on by specific immunologic mechanisms to cow's milk proteins. As one of the most common food allergies in infants, the incidence of CMA during the first year of life is estimated to be nearly 7.5%. Read More

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December 2020

Clinical implication and immunological characterisation of the ARF-GEF family member CYTH4 in ovarian cancer.

Autoimmunity 2020 12 20;53(8):434-442. Epub 2020 Oct 20.

Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: The GTP exchange factors on ADP-ribosylation factor (ARF) mediate the GDP/GTP exchange on ARF, serve as regulators in protein trafficking and membrane dynamics, and play critical roles in various cell processes. However, the relationship between the expression of ARF-GEF family genes and clinical implications in ovarian cancer remains unclear.

Methods: We performed a systematic investigation on the role of ARF-GEF family genes in ovarian cancer by using Gene Expression Omnibus (GEO), Kaplan-Meier plotter, Gene set enrichment analysis (GSEA), TIMER and TISIDB database. Read More

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December 2020

The clinical characteristics of autoimmune haemolytic anaemia/Evans syndrome patients with clonal immunoglobulin/T cell receptor gene rearrangement.

Autoimmunity 2020 11 14;53(7):394-399. Epub 2020 Sep 14.

Department of Hematology, General Hospital, Tianjin Medical University, Tianjin, China.

Objective: To investigate the clinical features of AIHA/ES patients with clonal Ig/TCR gene rearrangement.

Methods: Ig/TCR gene rearrangements were measured by BIOMED-2 PCR. 44 primary AIHA/ES patients were enrolled in the study. Read More

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November 2020

Auto-reactivity against gut bacterial peptides in patients with late-onset diabetes.

Autoimmunity 2020 11 14;53(7):385-393. Epub 2020 Sep 14.

National Institute of Pathology, Indian Council of Medical Research (ICMR), New Delhi, India.

The depletion of gut mucosal barrier enables exposure of gut microbes/gut microbial products to the host mucosal immunity which may increase the risk of metabolic/inflammatory disorders. These immune responses can lead to the development of mild autoimmunity to metabolic peptides coming from gut bacteria and may result in metabolic diseases like late-onset diabetes (LOD). In the present study, we identified host sera cross-reactivity with gut bacterial peptides similar to host proteins. Read More

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November 2020

Associations of genetic polymorphisms within , , and with genetic susceptibility to rheumatoid arthritis.

Autoimmunity 2020 11 10;53(7):408-414. Epub 2020 Sep 10.

Department of Preventive Medicine, Medical School of Ningbo University, Ningbo, Zhejiang, PR China.

Recently, several long non-coding RNAs (lncRNAs) including MALAT1, UCA1, ENST00000483588, and ENST00000456270 have been implicated in the pathogenesis of rheumatoid arthritis (RA), and we hypothesized that polymorphisms within these lncRNA genes might be genetic modifiers for the development of RA. A total of 10 potentially functional single-nucleotide polymorphisms (SNPs) were selected and genotyped in 1198 participants, including 594 RA patients and 604 healthy controls. Significant associations of rs2882581 (G vs. Read More

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November 2020