2,616 results match your criteria Autoimmunity[Journal]

LncRNA LINC00707 serves as a sponge of miR-382-5p to alleviate lipopolysaccharide (LPS)-induced WI-38 cell injury through upregulating NKAP in infantile pneumonia.

Autoimmunity 2022 May 20:1-11. Epub 2022 May 20.

Department of Respiratory medicine, Hunnan Children's Hospital, Changsha, China.

Infantile pneumonia (IP) is an acute lower respiratory infection that imposes a heavy burden on children's health. Increasing evidence has demonstrated that long non-coding RNA (lncRNA) LINC00707 participates in the regulation of the pneumonia process. Cell proliferative ability and apoptosis were measured using Cell Counting Kit-8 (CCK-8), 5-ethynyl-2'-deoxyuridine (EdU), and flow cytometry assays. Read More

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Associations between IL-23R gene polymorphism (rs10889677 A/C) and ankylosing spondylitis and rheumatoid arthritis susceptibility: A meta-analysis with trial sequential analysis.

Autoimmunity 2022 May 18:1-10. Epub 2022 May 18.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China.

Objectives: Autoimmune diseases are a kind of chronic diseases for which the immune system loses tolerance to autoantigens. This meta-analysis' purpose is to determine whether there exists a correlation between IL-23R polymorphism and common autoimmune diseases like ankylosing spondylitis (AS) and rheumatoid arthritis (RA).

Methods: We searched the relevant literatures up to September 2021 and used different effect models for meta-analysis. Read More

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Identification of SAA1 as a prognostic biomarker associated with immune infiltration in glioblastoma.

Autoimmunity 2022 May 14:1-10. Epub 2022 May 14.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.

Glioblastoma (GBM) is the most lethal tumour in the central nervous system (CNS), GBM has a poor prognosis due to treatment tolerance and tumour recurrence; new molecular biomarkers are needed to acquire accurate prognosis and to promote therapeutic strategies. Data from Gene Expression Omnibus (GEO) was analysed to screen differentially expressed genes (DEGs), and 279 DEGs were screened. The protein-protein interaction (PPI) network of DEGs was constructed and visualized, top 10 hub genes were identified by using Cytoscape consequently. Read More

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Sodium propionate improves rheumatoid arthritis by inhibiting survivin mediated proliferation of fibroblast like synoviocytes by promoting miR-140-5p.

Autoimmunity 2022 May 13:1-10. Epub 2022 May 13.

Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, Yunnan Province, China.

Background: Increased proliferation and impaired death of fibroblast-like synovial cells play an important role in the development of rheumatoid arthritis (RA). Survivin plays an important role in the prodromal stage and prognosis of RA and has been introduced as a biomarker of joint injury in RA patients. The purpose of this study was to explore whether propionate alleviates RA through miR-140-5p/survivin pathway. Read More

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A novel circRNA, circRACGAP1, hampers the progression of systemic lupus erythematosus via miR-22-3p-mediated AKT signalling.

Autoimmunity 2022 May 11:1-11. Epub 2022 May 11.

Department of Rheumatology and Immunology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China.

Background: Systemic lupus erythematosus (SLE) is defined as a multisystem autoimmune disease involving various organs, of which exact molecular mechanisms remain elusive. Here, we aimed to investigate a novel circular RNA (circRNA), circRACGAP1, abnormally expressed in SLE and explored its underlying regulatory network.

Methods: The expression patterns of circRACGAP1 were determined in patients diagnosed with SLE by using a qRT-PCR assay. Read More

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SLAMF8 promotes the proliferation and migration of synovial fibroblasts by regulating the ERK/MMPs signalling pathway.

Autoimmunity 2022 May 4:1-7. Epub 2022 May 4.

Department of Rheumatology and Immunology, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.

Rheumatoid arthritis is troublesome to treat effectively and often requires concomitant long-term treatment. Meanwhile, synovial fibroblasts could induce inflammation response and lead to joint erosion, finally causing progressive joint destruction, disability, and increased mortality. This study focussed on the role of SLAM family member 8 (SLAMF8) in mediating cell function from rheumatoid arthritis synovial fibroblasts stimulated with TNF-α. Read More

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Exosomal Dvl3 promoted the aggressive phenotypic transformation of RA-FLS via wnt pathway.

Autoimmunity 2022 May 2:1-9. Epub 2022 May 2.

Department of Rheumatology and Immunology, Changhai Hospital, The Second Military Medical University, Shanghai, China.

Objective: This study was performed to explore the function and mechanism of Dvl3 in RA-FLS by exosome intervention.

Methods: The expression pattern of Dvl3 was examined by IHC, WB, and qPCR. Modified exosomes obtained from culturing supernatant of RA-FLS infected with Dvl3 over expression (OE) lentivirus were administrated to the target RA-FLS. Read More

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CircTRHDE knockdown protects WI-38 cells against LPS-induced inflammatory injury.

Autoimmunity 2022 Apr 28:1-10. Epub 2022 Apr 28.

Department of Pediatrics, Zhengzhou Central Hospital, Zhengzhou University, Zhengzhou, Henan, China.

Background: Circular RNAs (circRNAs) have been reported to be involved in the progression of infantile pneumonia. Here, we investigated the function of circTRHDE in lipopolysaccharide (LPS)-induced cell inflammatory injury to evaluate its role in infantile pneumonia progression.

Methods: The circTRHDE, microRNA (miR)-381-3p and TNF-receptor associated factor 3 (TRAF3) expression were detected by quantitative real-time PCR. Read More

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Short interruptions of TNF-inhibitor treatment can be associated with treatment failure in patients with immune-mediated diseases.

Autoimmunity 2022 Apr 28:1-10. Epub 2022 Apr 28.

United Medix Laboratories, Helsinki, Finland.

Introduction: The prevalence of immune-mediated diseases has increased in the past decades and despite the use of biological treatments all patients do not achieve remission. The aim of this study was to characterise the reasons for short interruptions during treatment with two commonly used TNF-inhibitors infliximab and adalimumab and to analyse the possible effects of the interruptions on immunisation and switching the treatment.

Material And Methods: This case-control study was based on retrospective analyses of patient records and a questionnaire survey to clinicians. Read More

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MicroRNA-4287 alleviates inflammatory response targeting RIPK1 in osteoarthritis.

Autoimmunity 2022 Apr 28:1-9. Epub 2022 Apr 28.

Department of Orthopedics, Changzhou Cancer Hospital Affiliated to Soochow University, Changzhou, China.

Studies have confirmed the regulatory effects of microRNAs (miRNAs) in osteoarthritis (OA) progression. MiR-4287 has been identified by a previous study as a downregulated miRNA in chondrocytes treated with IL-1β and TNF-α. However, the function of the underlying mechanism of miR-4287 in OA is elusive. Read More

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Circular RNA circ_0002594 regulates PDGF-BB-induced proliferation and migration of human airway smooth muscle cells via sponging miR-139-5p/TRIM8 in asthma.

Autoimmunity 2022 Apr 26:1-12. Epub 2022 Apr 26.

Department of Pediatrics, Qinghuangdao First Hospital, Qinhuangdao, China.

Background: Asthma is a chronic respiratory disease characterised by the contraction of smooth muscle and remodelling of the airway wall, which is correlated with increased airway smooth muscle mass. Circular RNA (circRNA) circ_0002594 has been reported as a pro-inflammatory factor in allergic asthma. Therefore, this study is designed to explore the role and mechanism of circ_0002594 in human airway smooth muscle cells (HASMC) proliferation and metastasis. Read More

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Contribution of DNA methylation to the pathogenesis of Sjögren's syndrome: A review.

Autoimmunity 2022 Apr 9:1-8. Epub 2022 Apr 9.

Graduate Program in Dentistry, Centre of Health Sciences, Federal University of Paraíba - UFPB, João Pessoa, PB, Brazil.

Sjögren's syndrome (SS) is a chronic systemic disease characterised by salivary and lacrimal gland dysfunction with severe implications for the well-being of bearing individuals. Although its origin has not yet been fully elucidated, it is known that genetic, environmental, and epigenetic factors are important contributors to the pathogenesis of this syndrome. DNA methylation is a relevant, widely studied epigenetic factor that is possibly related to the establishment of SS. Read More

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Knockdown of circ-PRKCH alleviates IL-1β-treated chondrocyte cell phenotypic changes through modulating miR-502-5p/ADAMTS5 axis.

Autoimmunity 2022 May 30;55(3):179-191. Epub 2022 Mar 30.

Department of Orthopedics, Affiliated Hospital of Chifeng University, Institute of Orthopaedic Diseases, Affiliated Hospital of Chifeng University, Chifeng, China.

Background: Osteoarthritis (OA) is a common joint disease characterized by progressive cartilage degradation. Circular RNAs (circRNAs) are involved in the initiation and development of OA. This study aimed to explore the potential role and mechanism of circRNA protein kinase C eta (circ-PRKCH) in OA. Read More

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Circ_0088036 facilitates the proliferation and inflammation and inhibits the apoptosis of fibroblast-like synoviocytes through targeting miR-326/FZD4 axis in rheumatoid arthritis.

Autoimmunity 2022 May 30;55(3):157-167. Epub 2022 Mar 30.

Department of Gastric & Intestine, Affiliated Hospital of Chengde Medical College, Chengde, China.

Background: The function and pathological significance of circular RNAs (circRNAs) in autoimmune diseases, such as rheumatoid arthritis (RA), are barely known. Here, we explored the role of circ_0088036 in RA progression and its associated mechanism.

Methods: The synovial lining layer tissues of RA patients and non-RA control patients were collected for clinical study , and tumour necrosis factor α (TNF-α)-induced RA-fibroblast-like synoviocytes (RA-FLSs) were used for the experiments . Read More

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Circ_0060531 knockdown ameliorates IL-22-induced keratinocyte damage by binding to miR-330-5p to decrease GAB1 expression.

Autoimmunity 2022 Mar 16:1-11. Epub 2022 Mar 16.

Department of Dermatology, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan City, China.

Background: Psoriasis is a chronic immune-mediated skin disease. Recent studies showed its pathogenesis involved circular RNA (circRNA). However, the role of circ_0060531 in psoriasis development and the behind mechanism remain to be explored. Read More

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Inclisiran inhibits oxidized low-density lipoprotein-induced foam cell formation in Raw264.7 macrophages via activating the PPARγ pathway.

Autoimmunity 2022 Mar 15:1-10. Epub 2022 Mar 15.

Department of Geriatrics, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, P.R. China.

Proprotein convertase subtilisin kexin type 9 (PCSK9) is a well-known proprotein convertase that influences foam cell formation and modulates atherosclerosis. Inclisiran is a novel chemosynthetic small interfering RNA that inhibits PCSK9 synthesis. This study aimed to explore the effect of inclisiran on oxidized low-density lipoprotein (ox-LDL)-induced foam cell formation in Raw264. Read More

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Hsa_circ_0037128 aggravates high glucose-induced podocytes injury in diabetic nephropathy through mediating miR-31-5p/KLF9.

Autoimmunity 2022 Mar 14:1-10. Epub 2022 Mar 14.

Department of Hand Foot Surgery, Huizhou Central People's Hospital, Huizhou, China.

Background: Circular RNA is a key regulator involved in the progression of many human diseases including diabetic nephropathy (DN). However, the role and mechanism of hsa_circ_0037128 in the occurrence and development of DN remains to be explored.

Methods: High glucose (HG)-induced podocytes were used to construct DN models. Read More

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Serum anti-PAD4 autoantibodies are present in cystic fibrosis children and increase with age and lung disease severity.

Autoimmunity 2022 03 4;55(2):109-117. Epub 2022 Jan 4.

Division of Pulmonology, Allergy/Immunology, Cystic Fibrosis and Sleep, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.

Cystic fibrosis (CF) lung disease begins early in childhood and is characterized by neutrophilic inflammation of the airways. Neutrophil extracellular traps (NETs) represent one mechanism by which neutrophils contribute to lung damage. The enzyme peptidylarginine deiminase 4 (PAD4) is required for NET formation. Read More

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Circ_0110251 overexpression alleviates IL-1β-induced chondrocyte apoptosis and extracellular matrix degradation by regulating miR-3189-3p/SPRY1 axis in osteoarthritis.

Autoimmunity 2022 May 24;55(3):168-178. Epub 2022 Feb 24.

Department of Emergency Orthopedics, Gansu Provincial Hospital of TCM, Lanzhou, China.

Background: Mounting evidence indicates that circular RNAs (circRNAs) are involved in the progression of human diseases, including osteoarthritis (OA). In this study, we focussed on the functions and potential mechanism of circ_0110251 in OA.

Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) was conducted to determine the expression of circ_0110251, collagen type XI alpha 1 chain (COL11A1), microRNA-3189-3p (miR-3189-3p) and sprouty receptor tyrosine kinase signalling antagonist 1 (SPRY1). Read More

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Circ_0016347 modulates proliferation, migration, invasion, cell cycle, and apoptosis of osteosarcoma cells the miR-661/IL6R axis.

Autoimmunity 2022 Feb 15:1-11. Epub 2022 Feb 15.

Department of Spine Surgery, Tianjin Union Medical Center, Tianjin, China.

Background: Osteosarcoma is a common primary bone tumour in children and adolescents. Circular RNAs (circRNAs) exert vital functions in human diseases, including osteosarcoma. Therefore, we explored the role of circ_0016347 in osteosarcoma. Read More

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February 2022

Circ_0072008, an oncogene in pancreatic ductal adenocarcinoma, contributes to tumour cell malignant progression and glycolysis by regulating miR-545-3p/SLC7A11 axis.

Autoimmunity 2022 May 15;55(3):203-213. Epub 2022 Feb 15.

Department of Intensive Care Unit, Tengzhou Central People's Hospital of Shandong Province, Tengzhou City, China.

Background: The hsa_circRNA_103809 (circ_0072088) has been an emerging tumour regulator in human cancers, and is identified as one most aberrantly expressed circRNA in patients with pancreatic ductal adenocarcinoma (PDAC). However, the role of circ_0072088 remains unclear in PDAC cells.

Methods: Expression of circ_0072088, microRNA (miR)-545-3p and solute carrier family 7 member 11 (SLC7A11) was detected by real-time quantitative PCR and western blotting. Read More

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The small heat shock protein HSPB5 attenuates the severity of lupus nephritis in lupus-prone mice.

Autoimmunity 2022 May 9;55(3):192-202. Epub 2022 Feb 9.

Serenity Bioworks, Kitchener, Canada.

Lupus nephritis (LN) is a common and serious complication of systemic lupus erythematosus. The current treatments for LN are accompanied with severe immunotoxicity and have limits of effectiveness. Since our experiments demonstrated that a small heat shock protein (HSP), alpha-B crystallin (HSPB5; CRYAB), selectively modulates myeloid cells towards anti-inflammatory and tolerogenic phenotypes, the aim of this study was to investigate whether HSPB5 can attenuate the severity of LN. Read More

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Drug repurposing for rheumatoid arthritis: Identification of new drug candidates bioinformatics and text mining analysis.

Autoimmunity 2022 May 20;55(3):147-156. Epub 2022 Jan 20.

Department of Bioengineering, Adana Alparslan Türkeş Science and Technology University, Adana, Turkey.

Rheumatoid arthritis (RA) is an autoimmune disease that results in the destruction of tissue by attacks on the patient by his or her own immune system. Current treatment strategies are not sufficient to overcome RA. In the present study, various transcriptomic data from synovial fluids, synovial fluid-derived macrophages, and blood samples from patients with RA were analysed using bioinformatics approaches to identify tissue-specific repurposing drug candidates for RA. Read More

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High mobility group box 1 inhibition by BoxA attenuates ovalbumin-induced allergic rhinitis in mice.

Autoimmunity 2022 03 10;55(2):118-126. Epub 2022 Jan 10.

ENT Department 1, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.

This study was designed to evaluate the effects of BoxA on allergic rhinitis (AR). Ovalbumin (OVA)-induced AR mice model was employed and BoxA was administered to AR mice. AR symptoms, levels of cytokines and chemokines, and the expression of high mobility group box 1 (HMGB1), TLR2, and TLR4 were measured. Read More

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Circ_0003645 serves as miR-335-5p sponge to promote the biological process of diffuse large B-cell lymphoma by upregulating NFIB.

Autoimmunity 2022 Mar 8;55(2):127-135. Epub 2022 Jan 8.

Hematology Department, Zhangzhou Municipal Hospital of Fujian Province and Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, China.

Background: Circular RNAs (circRNAs) are critical regulators for the development of many tumours, including diffuse large B-cell lymphoma (DLBCL). However, the role and mechanism of circ_0003645 in DLBCL progression remains obscure.

Methods: Quantitative real-time PCR was performed to measure the expression of circ_0003645, microRNA (miR)-335-5p and nuclear factor I/B (NFIB). Read More

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LncRNA RP5-857K21.7 inhibits PDGF-BB-induced proliferation and migration of airway smooth muscle cells through the miR-508-3p/PI3K/AKT/mTOR axis.

Autoimmunity 2022 02 16;55(1):65-73. Epub 2021 Dec 16.

Department of Geratology, Yantai Yuhuangding Hospital, Yantai, China.

The continuous increase in the prevalence of asthma poses a threat to human health. Despites numerous researches, the understanding of asthma development still remain elusive, hindering the development of effective treatment. Here, we explored the role of lncRNA RP5-857K21. Read More

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February 2022

NIK-SIX1 signalling axis regulates high glucose-induced endothelial cell dysfunction and inflammation.

Autoimmunity 2022 03 13;55(2):86-94. Epub 2021 Dec 13.

Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Endothelial dysfunction and inflammation are the main manifestations of diabetes-associated atherosclerosis. This paper studied the roles of NF-κB-inducing kinase (NIK) and sine oculis homeobox homolog 1 (SIX1) in regulating high glucose-induced endothelial dysfunction and inflammation. The expression of NIK and SIX1 in human umbilical vein endothelial cells (HUVECs) was silenced by transfection with the specific shRNAs. Read More

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CircVMA21 ameliorates lipopolysaccharide (LPS)-induced HK-2 cell injury depending on the regulation of miR-7-5p/PPARA.

Autoimmunity 2022 03 13;55(2):136-146. Epub 2021 Dec 13.

Department of Cardiac Intensive Care Unit, Lanzhou University Second Hospital, Lanzhou,China.

Accumulating evidence suggests that circular RNAs (circRNAs) are implicated in diverse human diseases, including sepsis-engendered acute kidney injury (AKI). In this study, we investigated the functions of circRNA vacuolar ATPase assembly factor VMA21 (circVMA21) in septic AKI through establishing septic AKI model. Quantitative real-time polymerase chain reaction (qRT-PCR) assay was adopted to determine the levels of circVMA21, microRNA-7-5p (miR-7-5p) and peroxisome proliferator activated receptor alpha (PPARA) mRNA. Read More

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Gastrin producing syngeneic mesenchymal stem cells protect non-obese diabetic mice from type 1 diabetes.

Autoimmunity 2022 03 9;55(2):95-108. Epub 2021 Dec 9.

Department of Microbiology and Immunology, College of Medicine, Medical University of South Carolina, Charleston, SC, USA.

Progressive destruction of pancreatic islet β-cells by immune cells is a primary feature of type 1 diabetes (T1D) and therapies that can restore the functional β-cell mass are needed to alleviate disease progression. Here, we report the use of mesenchymal stromal/stem cells (MSCs) for the production and delivery of Gastrin, a peptide hormone that is produced by intestinal cells and foetal islets and can increase β-Cell mass, to promote protection from T1D. A single injection of syngeneic MSCs that were engineered to express Gastrin (Gastrin-MSCs) caused a significant delay in hyperglycaemia in non-obese diabetic (NOD) mice compared to engineered control-MSCs. Read More

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IL-21 impairs pro-inflammatory activity of M1-like macrophages exerting anti-inflammatory effects on rheumatoid arthritis.

Autoimmunity 2022 03 29;55(2):75-85. Epub 2021 Nov 29.

Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing, China.

Macrophages are the main source of inflammatory mediators and play important roles in the pathogenesis of rheumatoid arthritis (RA). Interleukin-21 (IL-21) regulates both innate and adaptive immune responses and exerts major effects on inflammatory responses that promote the development of RA. However, its effect on macrophage polarisation remains unclear. Read More

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