2,438 results match your criteria Autoimmunity [Journal]


Individual and stable autoantibody repertoires in healthy individuals.

Autoimmunity 2019 Mar 5:1-11. Epub 2019 Mar 5.

a SciLifeLab, Division of Affinity Proteomics, Department of Protein Science , KTH Royal Institute of Technology , Stockholm , Sweden.

In the era towards precision medicine, we here present the individual specific autoantibody signatures of 193 healthy individuals. The self-reactive IgG signatures are stable over time in a way that each individual profile is recognized in longitudinal sampling. The IgG autoantibody reactivity towards an antigen array comprising 335 protein fragments, representing 204 human proteins with potential relevance to autoimmune disorders, was measured in longitudinal plasma samples from 193 healthy individuals. Read More

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http://dx.doi.org/10.1080/08916934.2019.1581774DOI Listing

UBASH3A gene polymorphisms and expression profile in rheumatoid arthritis.

Autoimmunity 2019 Mar 1:1-6. Epub 2019 Mar 1.

a Department of Rheumatology and Immunology , the First Affiliated Hospital of Anhui Medical University , Hefei , Anhui , China.

Objectives: Recent evidence has demonstrated that UBASH3A play a pivotal role in multiple autoimmune diseases. In this study, we explored the association between UBASH3A gene single-nucleotide polymorphisms (SNPs) and rheumatoid arthritis (RA) in a Chinese Han population. We also comparatively evaluated the UBASH3A expression profile in peripheral blood mononuclear cells (PBMCs) from patients with RA and healthy controls. Read More

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http://dx.doi.org/10.1080/08916934.2019.1581773DOI Listing

CD5 B lymphocytes secrete IL-10 rather than TGF-β1 which control the immune response in autoimmune haemolytic anaemia/Evans syndrome.

Autoimmunity 2019 Feb 20:1-9. Epub 2019 Feb 20.

a Department of Hematology , General Hospital Tianjin Medical University , Tianjin , China.

Objective: To investigate the quantity and secretion function of cytokines-secreted CD5 B lymphocytes in Autoimmune Haemolytic Anaemia (AIHA)/Evans syndrome (ES) patients.

Methods: Twenty-five untreated AIHA/ES patients, 28 remission AIHA/ES patients and 25 healthy controls (HCs) were enrolled in this study. The quantity of CD5B lymphocytes which produce interleukin-10 (IL-10) (CD5IL-10) and transforming growth factor (TGF-β1) (CD5TGF-β1) were detected by flow cytometry (FCM). Read More

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http://dx.doi.org/10.1080/08916934.2019.1576644DOI Listing
February 2019
3 Reads

The changes in immune cell concentration during the progression of pre-diabetes to type 2 diabetes in a high-fat high-carbohydrate diet-induced pre-diabetic rat model.

Autoimmunity 2019 Feb 18:1-10. Epub 2019 Feb 18.

a Department of Human Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences , University of KwaZulu-Natal , Durban , South Africa.

Pre-diabetes is a long-lasting condition that precedes type 2 diabetes (T2D). T2D has been shown to suppress the immune response. However, it remains unclear if immune activation occurs before the onset of T2D during the progression of the pre-diabetic state. Read More

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http://dx.doi.org/10.1080/08916934.2019.1575820DOI Listing
February 2019

Islet autoantibody positivity in overweight and obese adults with type 2 diabetes.

Autoimmunity 2018 Dec 2;51(8):408-416. Epub 2019 Jan 2.

a Department of Medicine, Division of General Internal Medicine , The Johns Hopkins University School of Medicine, Baltimore , MD , USA.

Islet autoantibodies are typically associated with type 1 diabetes, but have been found in patients diagnosed with type 2 diabetes in whom they are associated with lower adiposity. The significance of autoantibody positivity in overweight and obese patients is not well understood. The aim of this study was to determine the prevalence and clinical significance of islet autoantibodies in overweight/obese adults diagnosed with type 2 diabetes. Read More

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http://dx.doi.org/10.1080/08916934.2018.1547711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362362PMC
December 2018
3 Reads

Immunotherapeutic effects of Mycobacterium tuberculosis rv3407 DNA vaccine in mice.

Autoimmunity 2018 Dec 11;51(8):417-422. Epub 2019 Jan 11.

a Army Tuberculosis Prevention and Control Key Laboratory , The 8th Medical Center of PLA General Hospital , Beijing , P. R. China.

Tuberculosis (TB) is a major global public health problem. Latent TB infection (LTBI) is a major source of active TB. New vaccines to treat LTBI are urgently demanded. Read More

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https://www.tandfonline.com/doi/full/10.1080/08916934.2018.1
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http://dx.doi.org/10.1080/08916934.2018.1546291DOI Listing
December 2018
7 Reads

Interleukin-6 and insulin-like growth factor-1 synergistically promote the progression of NSCLC.

Autoimmunity 2018 Dec 3;51(8):399-407. Epub 2019 Jan 3.

a Department of Thoracic and Cardiovascular Surgery , Zhongnan Hospital of Wuhan University , Wuhan , China.

The signaling pathways of interleukin-6 (IL-6) and insulin-like growth factor 1 (IGF-1) play an important role in the progression of lung cancer, and this study aimed to explore whether they can synergistically promote the progression of non-small cell lung cancer (NSCLC). We found that IL-6, glycoprotein 130 (GP130), IGF-1 and IGF-1R were highly expressed in NSCLC (p = .000), and there was the correlation between GP130, IGF-1, and IGF-1R (p < . Read More

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https://www.tandfonline.com/doi/full/10.1080/08916934.2018.1
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http://dx.doi.org/10.1080/08916934.2018.1550079DOI Listing
December 2018
7 Reads

Overexpression of toll-like receptor 9 correlates with podocyte injury in a murine model of autoimmune membranoproliferative glomerulonephritis.

Autoimmunity 2018 Dec 28;51(8):386-398. Epub 2018 Dec 28.

a Laboratory of Anatomy, Faculty of Veterinary Medicine, Department of Basic Veterinary Sciences , Hokkaido University , Sapporo , Japan.

Toll-like receptors (Tlrs) are sensors of danger signals which promote the activation of immune cells and intrinsic renal cells. Podocytes, the intrinsic cells of glomerulus, are continuously exposed to various plasma solutes and danger signals due to their unique location in the glomerulus. Herein, we show that Tlr9 is overexpressed in podocytes and the mechanisms which cause its injury and development of membranoproliferative glomerulonephritis (MPGN) in model BXSB/MpJ-Yaa (Yaa) mice. Read More

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http://dx.doi.org/10.1080/08916934.2018.1549234DOI Listing
December 2018
2 Reads

Bisphenol A: A notorious player in the mosaic of autoimmunity.

Autoimmunity 2018 Dec 28;51(8):370-377. Epub 2018 Dec 28.

b Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center , Tel-Hashomer , Israel.

The multifactorial etiology of autoimmune diseases has been studied at large. Genetic risk factors and environmental agents play an integral role in the pathogenesis of autoimmune processes. In recent decades, Bisphenol A (BPA), an exogenous compound found in polycarbonate plastic, has gained attention for its harmful multifocal effects on a diverse subset of systemic pathways, potentially contributing to disease onset and exacerbation. Read More

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http://dx.doi.org/10.1080/08916934.2018.1551374DOI Listing
December 2018
1 Read

IL-37 gene variant (rs3811047): A marker of disease activity in rheumatoid arthritis: A pilot study.

Autoimmunity 2018 Dec 28;51(8):378-385. Epub 2018 Dec 28.

a Clinical Pathology Department, Faculty of Medicine , Suez Canal University , Ismailia , Egypt.

Background: Rheumatoid arthritis (RA) is a joint destructive disorder with great morbidity. Unraveling genetic determinants causing the disease would pave the road towards early detection and precise medicine. Interleukin 37 (IL-37), a natural inhibitor of innate immunity, was shown to be a key modulator in RA. Read More

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http://dx.doi.org/10.1080/08916934.2018.1551373DOI Listing
December 2018
5 Reads

Childhood thyroid autoimmunity and relation to islet autoantibodies in children at risk for type 1 diabetes in the diabetes prediction in skåne (DiPiS) study.

Autoimmunity 2018 Aug;51(5):228-237

c Members of the DiPiS study group are listed in the Acknowledgement.

Background: The aim was to determine prevalence and age at seroconversion of thyroid autoimmunity in relation to islet autoantibodies, gender and HLA-DQ genotypes in children with increased risk for type 1 diabetes followed from birth.

Methods: In 10-year-old children (n = 1874), blood samples were analysed for autoantibodies against thyroid peroxidase (TPOAb), thyroglobulin (TGAb), glutamic acid decarboxylase 65 (GADA), Zink transporter 8 (ZnT8R/W/QA), insulinoma-associated protein-2 (IA-2A), insulin (IAA) and HLA-DQ genotypes. Prospectively collected samples from 2 years of age were next analysed for TPOAb, and TGAb and, finally, in confirming samples at 11-16 years of age along with TSH and FT4. Read More

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https://www.tandfonline.com/doi/full/10.1080/08916934.2018.1
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http://dx.doi.org/10.1080/08916934.2018.1519027DOI Listing
August 2018
5 Reads

Polymorphisms in Th17-related genes and the pathogenesis of autoimmune thyroid disease.

Autoimmunity 2018 Nov 24:1-10. Epub 2018 Nov 24.

a Department of Biomedical Informatics, Division of Health Sciences , Osaka University Graduate School of Medicine , Osaka , Japan.

The prognosis of autoimmune thyroid disease (AITD) including Graves' disease (GD) and Hashimoto's disease (HD) is difficult to predict. We previously suggested that Th17 cells may be associated with the pathogenesis of AITD. However, the association between gene polymorphisms in Th17-related genes and the prognosis of AITD was not clarified. Read More

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https://www.tandfonline.com/doi/full/10.1080/08916934.2018.1
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http://dx.doi.org/10.1080/08916934.2018.1534963DOI Listing
November 2018
19 Reads

Tissue transglutaminase autoantibodies in children with newly diagnosed type 1 diabetes are related to human leukocyte antigen but not to islet autoantibodies: A Swedish nationwide prospective population-based cohort study.

Autoimmunity 2018 Aug 16;51(5):221-227. Epub 2018 Nov 16.

d Department of clinical sciences , Lund University, Skåne University hospital , Malmö , Sweden.

Objectives: This study explored the association between tissue transglutaminase autoantibody (tTGA), high-risk human leucocyte antigen (HLA) genotypes and islet autoantibodies in children with newly diagnosed type 1 diabetes (T1D).

Patients And Methods: Dried blood spots and serum samples were taken at diagnosis from children <18 years of age participating in Better Diabetes Diagnosis (BDD), a Swedish nationwide prospective cohort study of children newly diagnosed with T1D. We analyzed tTGA, high-risk HLA DQ2 and DQ8 (DQX is neither DQ2 nor DQ8) and islet auto-antibodies (GADA, IA-2A, IAA, and three variants of Zinc transporter; ZnT8W, ZnT8R, and ZnT8QA). Read More

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http://dx.doi.org/10.1080/08916934.2018.1494160DOI Listing
August 2018
12 Reads

Immunization with plasmids encoding M2 acetylcholine muscarinic receptor epitopes impairs cardiac function in mice and induces autophagy in the myocardium.

Autoimmunity 2018 Aug 13;51(5):245-257. Epub 2018 Nov 13.

a Programa de Biologia Molecular e Estrutural, Instituto de Biofísica Carlos Chagas Filho , Universidade Federal do Rio de Janeiro , Rio de Janeiro , Brazil.

Autoantibodies against the M2 subtype of muscarinic acetylcholine receptors with functional activities have been found in the sera of patients with dilated cardiomyopathy (DCM), and the second extracellular loop has been established as the predominant epitope. However, it has been shown that the third intracellular loop is recognized by Chagas disease patients with severe cardiac dysfunction. In this work, BALB/c mice were immunized with plasmids encoding these two epitopes, and a control group received the empty plasmid (pcDNA3 vector). Read More

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https://www.tandfonline.com/doi/full/10.1080/08916934.2018.1
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http://dx.doi.org/10.1080/08916934.2018.1514389DOI Listing
August 2018
15 Reads

TREX1 D18N mice fail to process erythroblast DNA resulting in inflammation and dysfunctional erythropoiesis.

Autoimmunity 2018 Nov 13:1-12. Epub 2018 Nov 13.

a Department of Biochemistry , Center for Structural Biology, Wake Forest School of Medicine , Winston-Salem , NC , USA.

Anaemia is commonly observed in chronic inflammatory conditions, including systemic lupus erythematosus (SLE), where ∼50% of patients display clinical signs of anaemia. Mutation at the aspartate residue 18 of the three prime repair exonuclease 1 (TREX1) gene causes a monogenic form of cutaneous lupus in humans and the genetically precise TREX1 D18N mice recapitulate a lupus-like disease. TREX1 degrades single- and double-stranded DNA (dsDNA), and the link between failed DNA degradation by nucleases, including nucleoside-diphosphate kinases (NM23H1/H2) and Deoxyribonuclease II (DNase II), and anaemia prompted our studies to investigate whether TREX1 dysfunction contributes to anaemia. Read More

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http://dx.doi.org/10.1080/08916934.2018.1522305DOI Listing
November 2018
3 Reads

Burning controversies in NETs and autoimmunity: The mysteries of cell death and autoimmune disease.

Autoimmunity 2018 Sep 10;51(6):267-280. Epub 2018 Nov 10.

b Department of Microbiology, Immunology and Biochemistry , University of Tennessee Health Science Center , Memphis , TN , USA.

The causes and mechanisms of autoimmune disease pose continuing challenges to the scientific community. Recent clues implicate a peculiar feature of neutrophils, their ability to release nuclear chromatin in the form of neutrophil extracellular traps (NETs), in the induction or progression of autoimmune disease. Efforts to define the beneficial versus detrimental effects of NET release have, as yet, only partially revealed mechanisms that guide this process. Read More

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http://dx.doi.org/10.1080/08916934.2018.1523395DOI Listing
September 2018
1 Read

Periodontal sources of citrullinated antigens and TLR agonists related to RA.

Autoimmunity 2018 Sep 10;51(6):304-309. Epub 2018 Nov 10.

c Department of Internal Medicine 3 - Rheumatology and Immunology , Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen , Erlangen , Germany.

Anti-citrullinated protein autoantibodies (ACPA) precede the onset of clinical and subclinical rheumatoid arthritis (RA). ACPA are frequently generated in further chronic inflammatory diseases, e.g. Read More

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http://dx.doi.org/10.1080/08916934.2018.1527907DOI Listing
September 2018
2 Reads

New DiaP277 analogue shifts DCs to tolerogenic, and modulates NF-Kβ1 to suppress autoreactive T lymphocytes in the type 1 diabetic mice.

Autoimmunity 2018 Aug 1;51(5):210-220. Epub 2018 Nov 1.

c Minigene Pharmacy Laboratory, School of Life Science & Technology , China Pharmaceutical University , Nanjing , PR China.

Therapeutic efficacy of P277 against type 1 diabetes was extensively investigated and clinically evidenced. Clinical trials Phases I and II concluded promising results, while the data of P277 immunogenicity in Phase III trials represented weak responses that led to abolish medical use. But, a therapeutic performance of P277 cannot be forgotten. Read More

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https://www.tandfonline.com/doi/full/10.1080/08916934.2018.1
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http://dx.doi.org/10.1080/08916934.2018.1519704DOI Listing
August 2018
19 Reads
2.714 Impact Factor

Active NET formation in Libman-Sacks endocarditis without antiphospholipid antibodies: A dramatic onset of systemic lupus erythematosus.

Autoimmunity 2018 Sep 28;51(6):310-318. Epub 2018 Oct 28.

b Division of Neuro and Inflammation Sciences, Department of Clinical and Experimental Medicine , Linköping University , Linköping , Sweden.

Although neutrophil extracellular traps (NETs) have been highlighted in several systemic inflammatory diseases, their clinical correlates and potential pathological role remain obscure. Herein, we describe a dramatic onset of systemic lupus erythematosus (SLE) with clear-cut pathogenic implications for neutrophils and NET formation in a young woman with cardiac (Libman-Sacks endocarditis) and central nervous system (psychosis and seizures) involvement. Despite extensive search, circulating antiphospholipid autoantibodies, a hallmark of Libman-Sacks endocarditis, could not be detected. Read More

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https://www.tandfonline.com/doi/full/10.1080/08916934.2018.1
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http://dx.doi.org/10.1080/08916934.2018.1514496DOI Listing
September 2018
16 Reads

Neutrophil-released enzymes can influence composition of circulating immune complexes in multiple sclerosis.

Autoimmunity 2018 Oct 28:1-7. Epub 2018 Oct 28.

a Department of Histology and Cytology, Danylo Halytsky Lviv National Medical University , Pekarska str. 69,79010, Lviv , Ukraine.

During NET formation, the content of neutrophils granules is released into the intercellular milieu. Consisting of many proteases and ROS species, formed NETs were shown to degrade cytokines (Schauer, Nat Med, 2014); while the content of neutrophil's azurophilic granules proved to contain glycosidases, secreted upon activation (Thaysen-Andersen, JBC, 2015), and formation of autoantibodies to neutrophil beta-glucoronidase was connected with the level of anti-MPO antibodies (Ab) (Martensson, Autoimmunity, 1992). Taking into account these facts, we aimed to investigate the possibility of NET-related changes in glycan composition on circulating IgG molecules and IgG-IgM immune complexes in multiple sclerosis (MS). Read More

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https://www.tandfonline.com/doi/full/10.1080/08916934.2018.1
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http://dx.doi.org/10.1080/08916934.2018.1514390DOI Listing
October 2018
6 Reads

Autoimmune, rheumatic, chronic inflammatory diseases: Neutrophil extracellular traps on parade.

Autoimmunity 2018 Sep 29;51(6):281-287. Epub 2018 Oct 29.

a Department of Internal Medicine 3- Rheumatology and Immunology , Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen , Erlangen , Germany.

Rheumatic diseases are a group of inflammatory conditions that affect joints and connective tissues and are often accompanied by pain and restriction of motility. In many of these diseases, autoantibodies develop that react with molecules/structures commonly found hidden in neutrophils. Neutrophil extracellular trap (NET) formation and release is considered a defense mechanism against pathogens or endogenous danger signals and it has been associated with initial inflammatory responses. Read More

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https://www.tandfonline.com/doi/full/10.1080/08916934.2018.1
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http://dx.doi.org/10.1080/08916934.2018.1519804DOI Listing
September 2018
16 Reads

DNA hypermethylation of SFRP2 influences the pathology of rheumatoid arthritis through the canonical Wnt signaling in model rats.

Autoimmunity 2018 Oct 20:1-14. Epub 2018 Oct 20.

a Department of Pharmacy, School of Life and Health Science , Anhui Science and Technology University , Fengyang , China.

In this work, the expression of secreted frizzled related protein 2 (SFRP2) in rheumatoid arthritis (RA) model rats and the mechanisms of SFRP2 on the RA pathogenesis were investigated. Data suggested that SFRP2 was significantly down-regulated in RA model rats compared with normal control, and overexpression of SFRP2 suppressed the RA pathogenesis and the canonical Wnt signaling in fibroblast-like synovial cells (FLS) from RA model rats, whereas knockdown of SFRP2 got an opposite observation. Interestingly, 5-azadC treatment up-regulated the SFRP2 expression, inhibited the FLS proliferation, suppressed the expression of IL-6 and IL-8 and the fibronectin production, suggesting that the decreased SFRP2 in RA model rats was due to the DNA methylation. Read More

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http://dx.doi.org/10.1080/08916934.2018.1516760DOI Listing
October 2018
2 Reads

Increased circulating Tfh17 and PD-1Tfh cells are associated with autoantibodies in Hashimoto's thyroiditis.

Autoimmunity 2018 Nov 20;51(7):352-359. Epub 2018 Oct 20.

e Department of Clinical Laboratory , Zhejiang Provincial People's Hospital, Hangzhou Medical College , Hangzhou , PR China.

Objective: Hashimoto's thyroiditis (HT) is characterized by autoantibodies targeting the thyroid. Abnormal CD4CXCR5T cell levels were previously shown to be associated with HT. However, Tfh cells consist of heterogeneous subpopulations, and which T follicular helper (Tfh) cell subpopulation participates in the pathogenesis of HT remains poorly understood. Read More

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http://dx.doi.org/10.1080/08916934.2018.1516761DOI Listing
November 2018
5 Reads

Increased circulating follicular regulatory T cells in Hashimoto's thyroiditis.

Autoimmunity 2018 Nov 20;51(7):345-351. Epub 2018 Oct 20.

d Department of Clinical Laboratory , Zhejiang Provincial People's Hospital, Hangzhou Medical College , Hangzhou , China.

Objective: Follicular T helper (Tfh) cells are involved in the pathogenesis of Hashimoto's thyroiditis (HT), while follicular T regulatory (Tfr) cells inhibit Tfh cells, which mediate B cell responses. However, the role of Tfr cells in HT remains unclear.

Methods: Forty-six healthy controls (HCs) and 84 HT patients were enrolled in the study. Read More

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http://dx.doi.org/10.1080/08916934.2018.1516759DOI Listing
November 2018
15 Reads

Immunoregulatory effects of indole-3-carbinol on monocyte-derived macrophages in systemic lupus erythematosus: A crucial role for aryl hydrocarbon receptor.

Autoimmunity 2018 Aug 5;51(5):199-209. Epub 2018 Oct 5.

e Infectious Diseases Research Center and Laboratory Science Research Center , Golestan University of Medical Sciences , Gorgan , Iran.

Macrophages are versatile phagocytic cells in immune system with immunoregulatory functions. However, the removal of apoptotic cells by macrophages is disturbed in systemic lupus erythematosus (SLE). Aryl hydrocarbon receptor (AhR) is a ligand-activated cytoplasmic receptor and transcription factor with diverse effects on immune response. Read More

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https://www.tandfonline.com/doi/full/10.1080/08916934.2018.1
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http://dx.doi.org/10.1080/08916934.2018.1494161DOI Listing
August 2018
4 Reads
2.714 Impact Factor

Oestrogen receptor β5 and epidermal growth factor receptor synergistically promote lung cancer progression.

Autoimmunity 2018 Jun 19;51(4):157-165. Epub 2018 Jul 19.

a Department of Thoracic and Cardiovascular Surgery , Zhongnan Hospital of Wuhan University , Wuhan , China.

Oestrogen receptor beta (ERβ) and epidermal growth factor receptor (EGFR) pathway can synergistically promote the proliferation, invasion, and metastasis of non-small-cell lung cancer (NSCLC) cells. ERβ has five subtypes, and the selective splicing of exon 8 in ERβ5 transcription translational phase makes its biological function different from other subtypes. The following study investigates whether ERβ5 interacts with EGFR pathway in lung cancer. Read More

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http://dx.doi.org/10.1080/08916934.2018.1486825DOI Listing
June 2018
7 Reads

The association of non-alcoholic fatty liver disease with thyroid peroxidase and thyroglobulin antibody: A new insight from SPECT-China study.

Autoimmunity 2018 Aug 17;51(5):238-244. Epub 2018 Jul 17.

a Institute and Department of Endocrinology and Metabolism , Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China.

Non-alcoholic fatty liver disease (NAFLD) has been studied with inflammation and immune, but the link with thyroid autoimmunity is unreported. This study aimed to explore the direct association of NAFLD with thyroid autoimmune disease (AITD) among participants with normal thyroid stimulating hormone (TSH) levels. The data were obtained from a cross-sectional study (SPECT-China). Read More

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http://dx.doi.org/10.1080/08916934.2018.1488968DOI Listing
August 2018
9 Reads

Complex interaction between mutant HNRNPA1 and gE of varicella zoster virus in pathogenesis of multiple sclerosis.

Autoimmunity 2018 Jun 11;51(4):147-151. Epub 2018 Jul 11.

a Laboratory of Genomic Sciences, Department of Studies in Genetics and Genomics , University of Mysore , Mysore , Karnataka , India.

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system causing axonal injury, neuronal loss, and atrophy of the central nervous system leading to permanent neurological and clinical disability. Presence of mutations in M9 domain of HNRNPA1 and detection of autoantibodies against this domain in HNRNPA1 qualifies it as a strong candidate for causing MS. These two aspects indicate the presence of a facilitator in associating them. Read More

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http://dx.doi.org/10.1080/08916934.2018.1482883DOI Listing
June 2018
9 Reads

Analysis of chosen polymorphisms rs2476601 a/G - PTPN22, rs1990760 C/T - IFIH1, rs179247 a/G - TSHR in pathogenesis of autoimmune thyroid diseases in children.

Autoimmunity 2018 Jun 4;51(4):183-190. Epub 2018 Jul 4.

a Department of Pediatric Endocrinology , Diabetology with Cardiology Division, Medical University of Białystok , Białystok , Poland.

Background: Autoimmune thyroid diseases are multifactorial diseases with a genetic susceptibility and environmental factors. A potential role of the protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene, the interferon-induced helicase domain 1 (IFIH1) gene, the thyroid-stimulating hormone receptor (TSHR) gene polymorphisms on autoimmune thyroid diseases (AITDs) in adults has been established unequivocally, but there is still lack of research articles including group of children. Objective and hypotheses: To estimate the association of polymorphisms of PTPN22, IFIH1 and TSH-R genes with the pre-disposition to Graves' disease (GD) and Hashimoto's thyroiditis (HT) in children. Read More

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http://dx.doi.org/10.1080/08916934.2018.1486824DOI Listing
June 2018
21 Reads

Evidence of increased humoral endocrine organ-specific autoimmunity in severe and classic X-chromosome aneuploidies in comparison with 46,XY control subjects.

Autoimmunity 2018 Jun 28;51(4):175-182. Epub 2018 Jun 28.

a Section of Medical Pathophysiology, Center of Rare Diseases, Department of Experimental Medicine , Sapienza University of Rome , Rome , Italy.

Objective: In literature, the importance of X-linked gene dosage as a contributing factor for autoimmune diseases is generally assumed. However, little information is available on the frequency of humoral endocrine organ-specific autoimmunity in X-chromosome aneuploidies. In our preliminary study, we investigated the endocrine organ-specific humoral autoimmunity relative to four different organ-specific autoimmune diseases in a group of adult 47,XXY KS patients and in adults 46,XY control males (type 1 diabetes, T1DM; Addison's disease, AD; Hashimoto thyroiditis, HT; autoimmune chronic atrophic gastritis, AG). Read More

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http://dx.doi.org/10.1080/08916934.2018.1477134DOI Listing
June 2018
13 Reads

Race/ethnicity is an independent risk factor for autoimmune hepatitis among the San Francisco underserved.

Autoimmunity 2018 Aug 11;51(5):258-264. Epub 2018 Jun 11.

d Department of Medicine, Division of Gastroenterology , University of California San Francisco , San Francisco , CA , USA.

Although autoimmune hepatitis (AIH) is more common in women and affects people of all races/ethnicities, there is currently limited information regarding the relationship between race/ethnicity and AIH, especially in the context of underserved populations. We aim to evaluate the relationship between race/ethnicity and AIH and better characterize its clinical features among different racial groups. We conducted a 15-year retrospective analysis, from January 2002 to June 2017, of patients seen at Zuckerberg San Francisco General Hospital (ZSFG). Read More

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http://dx.doi.org/10.1080/08916934.2018.1482884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311708PMC
August 2018
18 Reads

Clinical significance of combined detection of interleukin-6 and tumour markers in lung cancer.

Autoimmunity 2018 Jun 5;51(4):191-198. Epub 2018 Jun 5.

a Department of Thoracic and Cardiovascular Surgery , Zhongnan Hospital of Wuhan University , Wuhan , Hubei , China.

Tumour markers play an important role in the early diagnosis and guidance of prognosis of lung cancer. This study focused on the significance of combined monitoring of interleukin (IL)-6 and tumour markers in improving the specificity and sensitivity of lung cancer diagnosis and disease. The expression of IL-6, carcinoembryonic antigen (CEA), neuron-specific enolase (NSE) and cytokeratin 19 fragment antigen 21-1 (CYFRA21-1) in serum of patients with non-small cell lung cancer (NSCLC) (n = 138) was significantly higher compared to patients with benign pulmonary lesions (BPL) (n = 60) and was associated with the clinicopathological features of NSCLC patients. Read More

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http://dx.doi.org/10.1080/08916934.2018.1477133DOI Listing
June 2018
4 Reads

Features of peripheral CD8CD57 lymphocytes in patients with autoimmune hemolytic anemia.

Autoimmunity 2018 Jun 30;51(4):166-174. Epub 2018 May 30.

a Department of Biomedical Sciences and Human Oncology , University of Bari "Aldo Moro" , Bari , Italy.

Autoimmune hemolytic anemia (AIHA) is an acquired condition characterized by the presence of autoantibodies recognizing erythrocyte-related antigens. Several components of the immune system are involved in disease pathogenesis. Among them, as for other autoimmune disorders, a role for specific CD8CD57 regulatory cells subset could be hypothesized. Read More

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http://dx.doi.org/10.1080/08916934.2018.1477132DOI Listing
June 2018
4 Reads

Glycosylation of random IgG distinguishes seropositive and seronegative rheumatoid arthritis.

Autoimmunity 2018 May 7;51(3):111-117. Epub 2018 May 7.

a Department of Internal Medicine 3 - Rheumatology and Immunology , Friedrich-Alexander Universität Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen , Erlangen , Germany.

The N-glycosylation of human immunoglobulins, especially IgGs, plays a critical role in determining affinity of IgGs towards their effector (pro- and anti-inflammatory) receptors. However, it is still not clear whether altered glycosylation is involved in only antibody-dependent disorders like seropositive rheumatoid arthritis (RA) or also in pathologies with similar clinical manifestations, but no specific autoantibodies like seronegative RA. The clarification of that uncertainty was the aim of the current study. Read More

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http://dx.doi.org/10.1080/08916934.2018.1468886DOI Listing
May 2018
6 Reads

New genetically engineered DFS70 knock-out HEp-2 cells enable rapid and specific recognition of anti-DFS70 antibodies.

Autoimmunity 2018 Jun 6;51(4):152-156. Epub 2018 May 6.

b Azienda Sanitaria Universitaria Integrata , Udine , Italy.

Background: The correct identification of anti-dense fine speckled-70 (DFS70) antibodies represents an important issue in the detection of anti-nuclear antibodies (ANAs) as performed by the indirect immunofluorescence (IIF) test on HEp-2 substrates. In this study, we have evaluated a new method for anti-DFS70 antibody detection employing HEp-2 cells knocked-out for the DFS70 antigen.

Methods: We studied 148 sera with a DFS70-like pattern (91 positive and 57 negative when tested for anti-DFS70 antibodies by a specific chemoluminescence [CLIA] method); 116 sera with infectious disease; 100 healthy donors (HDs), 139 samples from patients with a defined diagnosis of autoimmune rheumatic disease (ARD), and 242 consecutive unselected samples screened for ANA during the routine work-up. Read More

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https://www.tandfonline.com/doi/full/10.1080/08916934.2018.1
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http://dx.doi.org/10.1080/08916934.2018.1469013DOI Listing
June 2018
17 Reads

SAMHD1: Recurring roles in cell cycle, viral restriction, cancer, and innate immunity.

Autoimmunity 2018 May 27;51(3):96-110. Epub 2018 Mar 27.

a Department of Biochemistry , Center for Structural Biology, Wake Forest School of Medicine , Winston Salem , NC , USA.

Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1) is a deoxynucleotide triphosphate (dNTP) hydrolase that plays an important role in the homeostatic balance of cellular dNTPs. Its emerging role as an effector of innate immunity is affirmed by mutations in the SAMHD1 gene that cause the severe autoimmune disease, Aicardi-Goutieres syndrome (AGS) and that are linked to cancer. Additionally, SAMHD1 functions as a restriction factor for retroviruses, such as HIV. Read More

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http://dx.doi.org/10.1080/08916934.2018.1454912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117824PMC
May 2018
4 Reads

Altered expression of transcription factors IRF4 and IRF8 in peripheral blood B cells is associated with clinical severity and circulating plasma cells frequency in patients with myasthenia gravis.

Autoimmunity 2018 May 23;51(3):126-134. Epub 2018 Mar 23.

a Department of Neurology , Affiliated Hospital of Xuzhou Medical University , Xuzhou , Jiangsu , China.

Previous studies have shown that interferon regulatory factor-4 (IRF4) and IRF8 play critical but distinct roles in the differentiation of B cells into plasma cells (PCs). In the present study, we aimed to measure the expression levels of IRF4 and IRF8 in B cells from patients with myasthenia gravis (MG) and to investigate whether the expression of IRF4 and IRF8 associates with pathogenesis of MG. A total of 35 anti-acetylcholine receptor (AChR) antibody (Ab)-positive patients with MG [20 generalized MG (GMG) and 15 ocular MG (OMG) and 25 healthy donors were recruited in this study. Read More

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http://dx.doi.org/10.1080/08916934.2018.1454913DOI Listing
May 2018
48 Reads

Methylation levels of the TNFA gene are different between Graves' and Hashimoto's diseases and influenced by the TNFA polymorphism.

Autoimmunity 2018 May 11;51(3):118-125. Epub 2018 Mar 11.

a Department of Biomedical Informatics, Division of Health Sciences , Osaka University Graduate School of Medicine , Suita , Osaka , Japan.

Graves' disease (GD) and Hashimoto's disease (HD) are different pathological types of autoimmune thyroid diseases (AITDs). However, the epigenetic differences between these diseases have not been elucidated. DNA methylation is one of the primary epigenetic modifications that reflect environmental influences on gene expression. Read More

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http://dx.doi.org/10.1080/08916934.2018.1448078DOI Listing
May 2018
7 Reads

Signalling pathways identified in salivary glands from primary Sjögren's syndrome patients reveal enhanced adipose tissue development.

Autoimmunity 2018 May 5;51(3):135-146. Epub 2018 Mar 5.

b Department of Clinical Medicine, Gade Laboratory for Pathology , University of Bergen , Bergen , Norway.

A characteristic feature of primary Sjögren's syndrome (pSS) is the destruction of salivary and lacrimal glands mediated by mononuclear cell infiltration. Adipocytes can also occupy a large portion of the salivary gland (SG) tissue area, although little is known about their significance in pSS. We have previously investigated adipose tissue infiltration in SG biopsies from pSS patients and non-SS sicca controls. Read More

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http://dx.doi.org/10.1080/08916934.2018.1446525DOI Listing
May 2018
7 Reads

Protective effects of quercetin treatment in a pristane-induced mouse model of lupus nephritis.

Autoimmunity 2018 Mar 26;51(2):69-80. Epub 2018 Feb 26.

a Graduate Program in Medical Sciences , Universidade Federal do Rio Grande do Sul , Porto Alegre , Brazil.

Introduction: Lupus nephritis (LN) is one of the most severe complications of systemic lupus erythematosus. As murine models of LN are valuable tools to better understand its pathophysiology and to search for new effective treatments, we investigated the effects of the bioflavonoid quercetin on pristane-induced LN mice through histomorphological analyses.

Methods: Immunofluorescence and biochemical assays were used to evaluate the expression of markers of inflammation (interleukin-6, IL-6; tumour necrosis factor-α, TNF-α), oxidative stress (catalase, CAT; superoxide dismutase 1, SOD1; thiobarbituric acid reactive substances, TBARS), apoptosis (Bax), and fibrosis (transforming growth factor-β1, TGF-β1). Read More

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http://dx.doi.org/10.1080/08916934.2018.1442828DOI Listing
March 2018
7 Reads

miR-148b-3p affects the pathogenesis of adjuvant-induced arthritis rats through the direct target DNMT1.

Autoimmunity 2018 Mar 23;51(2):43-52. Epub 2018 Feb 23.

a Department of Pharmacy, School of Food and Drug , Anhui Science and Technology University , Fengyang , China.

Our previous study showed that up-regulated DNA methyltransferase-1 (DNMT1) played an important role in the hypermethylation modification of SFRP4 in adjuvant-induced arthritis (AIA) rats. This work focused on the role of disordered miR-148b-3p in RA pathology and its corresponding regulatory targets. The expression of miR-148b-3p and DNMT1, and the effect of miR-148b-3p on the DNMT1 expression were determined by real-time qPCR, western blotting and double luciferase reporter genes. Read More

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http://dx.doi.org/10.1080/08916934.2018.1442441DOI Listing
March 2018
17 Reads

Alterations in nucleotide-binding oligomerization domain-2 expression, pathway activation, and cytokine production in Yao syndrome.

Autoimmunity 2018 Mar 22;51(2):53-61. Epub 2018 Feb 22.

b Department of Rheumatic and Immunologic Disease , Orthopaedic and Rheumatologic Institute, Cleveland Clinic , Cleveland , OH , USA.

Yao syndrome (YAOS) is a systemic autoinflammatory disease (SAID), formerly termed nucleotide-binding oligomerization domain-2 (NOD2)-associated autoinflammatory disease. Due to the recent identification of YAOS, the molecular mechanisms underlying its disease pathogenesis are unclear. With specific NOD2 variants as characteristic genotypic features of YAOS, our study examined NOD2 expression, transcript splicing, signaling pathway activation, and cytokine profiles in peripheral blood mononuclear cells (PBMCs) from 10 YAOS patients and six healthy individuals. Read More

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http://dx.doi.org/10.1080/08916934.2018.1442442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036904PMC
March 2018
21 Reads

Clinical contribution of myositis-related antibodies detected by immunoblot to idiopathic inflammatory myositis: A one-year retrospective study.

Autoimmunity 2018 Mar 20;51(2):89-95. Epub 2018 Feb 20.

b Centre de Recherche en Transplantation et Immunologie (CRTI), UMR 1064, Inserm , Université de Nantes , Nantes , France.

In this study, we aimed at evaluating the contribution of an extended myositis-related antibodies (Abs) determination by immunoblot to the diagnosis, classification, and prognosis of idiopathic inflammatory myositis (IIM). Medical records of all the patients (n = 237) with myositis-related Ab requests addressed to our department over a one-year period were retrospectively analyzed. Patients were classified as IIM, auto-immune disease (AID) other than IIM, and other diagnosis, and examined for their Ab profiles as determined by immunoblot. Read More

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http://dx.doi.org/10.1080/08916934.2018.1441830DOI Listing
March 2018
10 Reads

Functional TSH receptor antibodies in children with autoimmune thyroid diseases.

Autoimmunity 2018 Mar 26;51(2):62-68. Epub 2018 Jan 26.

j Molecular Thyroid Research Laboratory, Department of Medicine I , Johannes Gutenberg University (JGU) Medical Center , Mainz , Germany.

Introduction: The diagnostic value of the level of TSH receptor antibodies (TSHR-Ab) in the population of children with autoimmune thyroid diseases (AITDs) is still unknown. The aim of this cross-sectional study was to investigate the prevalence of TSHR-Ab in a paediatric cohort with AITD and healthy controls.

Materials And Methods: A total of 240 serum samples were obtained from 205 patients with AITD, type 1 diabetes (T1D), juvenile arthritis (JA), and healthy controls (C). Read More

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http://dx.doi.org/10.1080/08916934.2018.1431776DOI Listing
March 2018
8 Reads

Bone marrow mesenchymal stem cells suppress IL-9 in adjuvant-induced arthritis.

Autoimmunity 2018 Feb 23;51(1):25-34. Epub 2018 Jan 23.

a Zoology Department, Faculty of Women for Arts, Science and Education , Ain Shams University , Cairo , Egypt.

Interleukin-9 (IL-9) has been shown to be upregulated in rheumatoid arthritis (RA). The exact role of IL-9 has not yet been effectively studied. Mesenchymal stem cells (MSCs) have shown a promising immunomodulatory role towards repairing cartilage and restoring joint function. Read More

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http://dx.doi.org/10.1080/08916934.2018.1428956DOI Listing
February 2018
6 Reads

Celiac antibodies in children with type 1 diabetes - A diagnostic validation study.

Autoimmunity 2018 Mar 19;51(2):81-88. Epub 2018 Jan 19.

a Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age , Medical University of Warsaw , Warsaw , Poland.

Introduction: Autoimmune diseases, such as celiac disease (CD) and diabetes mellitus type 1, tend to co-occur within the same patient. The prevalence of CD in diabetic children is higher than in the general population, and is estimated to be 0.6-16. Read More

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https://www.tandfonline.com/doi/full/10.1080/08916934.2018.1
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http://dx.doi.org/10.1080/08916934.2018.1427226DOI Listing
March 2018
22 Reads

Gain of function mutant of complement factor B K323E mimics pathogenic C3NeF autoantibodies in convertase assays.

Autoimmunity 2018 Feb 8;51(1):18-24. Epub 2018 Jan 8.

a Department of Medical Biotechnology , Intercollegiate Faculty of Biotechnology UG-GUMED , Gdańsk , Poland.

Complement convertases are enzymatic complexes, which play a critical role in propagation and amplification of the complement cascade. Under physiological conditions, convertases decay shortly after being formed in either spontaneous or inhibitor-driven process. Prolongation of their half-life by C3NeF autoantibodies that prevent convertase dissociation results in pathogenic condition often manifested by renal diseases. Read More

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http://dx.doi.org/10.1080/08916934.2017.1423286DOI Listing
February 2018
6 Reads

Deficiency of autoimmune regulator impairs the immune tolerance effect of bone marrow-derived dendritic cells in mice.

Autoimmunity 2018 Feb 3;51(1):10-17. Epub 2018 Jan 3.

a Department of Immunology, College of Basic Medical Sciences , Jilin University , Changchun , Jilin , China.

As a transcription factor, autoimmune regulator (Aire) participates in thymic negative selection and maintains immune tolerance mainly by regulating the ectopic expression of tissue-restricted antigens (TRAs) in medullary thymic epithelial cells (mTECs). Aire is also expressed in dendritic cells (DCs). DCs are professional antigen-presenting cells (APCs) that affect the differentiation of T cells toward distinct subpopulations and participate in the immune response and tolerance, thereby playing an important role in maintaining homeostasis. Read More

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http://dx.doi.org/10.1080/08916934.2017.1422124DOI Listing
February 2018
54 Reads

IL-17 and related cytokines involved in systemic sclerosis: Perspectives.

Autoimmunity 2018 Feb 19;51(1):1-9. Epub 2017 Dec 19.

b Laboratório de Imunomodulação e Novas Abordagens Terapêuticas Suely Galdino , Universidade Federal de Pernambuco , Recife , Brazil.

Systemic sclerosis (SSc) is a multisystemic, complex, and rare disease of connective tissue, with high morbidity and mortality, and without specific treatment. The disease is characterized by three main principles: vascular disease, autoantibody production and inflammation, and fibrosis. Since it is well defined that SSc is characterized by elevated production of TGF-β, IL-6, and IL-1, all of them cytokines related to Th17 differentiation, the hypothesis is that this disease may be strongly related to a polarization of the immune response towards the Th17 pathway. Read More

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http://dx.doi.org/10.1080/08916934.2017.1416467DOI Listing
February 2018
11 Reads