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    2396 results match your criteria Autoimmunity [Journal]

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    Alterations in nucleotide-binding oligomerization domain-2 expression, pathway activation, and cytokine production in Yao syndrome.
    Autoimmunity 2018 Feb 22:1-9. Epub 2018 Feb 22.
    b Department of Rheumatic and Immunologic Disease , Orthopaedic and Rheumatologic Institute, Cleveland Clinic , Cleveland , OH , USA.
    Yao syndrome (YAOS) is a systemic autoinflammatory disease (SAID), formerly termed nucleotide-binding oligomerization domain-2 (NOD2)-associated autoinflammatory disease. Due to the recent identification of YAOS, the molecular mechanisms underlying its disease pathogenesis are unclear. With specific NOD2 variants as characteristic genotypic features of YAOS, our study examined NOD2 expression, transcript splicing, signaling pathway activation, and cytokine profiles in peripheral blood mononuclear cells (PBMCs) from 10 YAOS patients and six healthy individuals. Read More

    Clinical contribution of myositis-related antibodies detected by immunoblot to idiopathic inflammatory myositis: A one-year retrospective study.
    Autoimmunity 2018 Feb 20:1-7. Epub 2018 Feb 20.
    b Centre de Recherche en Transplantation et Immunologie (CRTI), UMR 1064, Inserm , Université de Nantes , Nantes , France.
    In this study, we aimed at evaluating the contribution of an extended myositis-related antibodies (Abs) determination by immunoblot to the diagnosis, classification, and prognosis of idiopathic inflammatory myositis (IIM). Medical records of all the patients (n = 237) with myositis-related Ab requests addressed to our department over a one-year period were retrospectively analyzed. Patients were classified as IIM, auto-immune disease (AID) other than IIM, and other diagnosis, and examined for their Ab profiles as determined by immunoblot. Read More

    Functional TSH receptor antibodies in children with autoimmune thyroid diseases.
    Autoimmunity 2018 Jan 26:1-7. Epub 2018 Jan 26.
    j Molecular Thyroid Research Laboratory, Department of Medicine I , Johannes Gutenberg University (JGU) Medical Center , Mainz , Germany.
    Introduction: The diagnostic value of the level of TSH receptor antibodies (TSHR-Ab) in the population of children with autoimmune thyroid diseases (AITDs) is still unknown. The aim of this cross-sectional study was to investigate the prevalence of TSHR-Ab in a paediatric cohort with AITD and healthy controls.

    Materials And Methods: A total of 240 serum samples were obtained from 205 patients with AITD, type 1 diabetes (T1D), juvenile arthritis (JA), and healthy controls (C). Read More

    Bone marrow mesenchymal stem cells suppress IL-9 in adjuvant-induced arthritis.
    Autoimmunity 2018 Feb 23;51(1):25-34. Epub 2018 Jan 23.
    a Zoology Department, Faculty of Women for Arts, Science and Education , Ain Shams University , Cairo , Egypt.
    Interleukin-9 (IL-9) has been shown to be upregulated in rheumatoid arthritis (RA). The exact role of IL-9 has not yet been effectively studied. Mesenchymal stem cells (MSCs) have shown a promising immunomodulatory role towards repairing cartilage and restoring joint function. Read More

    Celiac antibodies in children with type 1 diabetes - A diagnostic validation study.
    Autoimmunity 2018 Jan 19:1-8. Epub 2018 Jan 19.
    a Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age , Medical University of Warsaw , Warsaw , Poland.
    Introduction: Autoimmune diseases, such as celiac disease (CD) and diabetes mellitus type 1, tend to co-occur within the same patient. The prevalence of CD in diabetic children is higher than in the general population, and is estimated to be 0.6-16. Read More

    Gain of function mutant of complement factor B K323E mimics pathogenic C3NeF autoantibodies in convertase assays.
    Autoimmunity 2018 Feb 8;51(1):18-24. Epub 2018 Jan 8.
    a Department of Medical Biotechnology , Intercollegiate Faculty of Biotechnology UG-GUMED , Gdańsk , Poland.
    Complement convertases are enzymatic complexes, which play a critical role in propagation and amplification of the complement cascade. Under physiological conditions, convertases decay shortly after being formed in either spontaneous or inhibitor-driven process. Prolongation of their half-life by C3NeF autoantibodies that prevent convertase dissociation results in pathogenic condition often manifested by renal diseases. Read More

    Deficiency of autoimmune regulator impairs the immune tolerance effect of bone marrow-derived dendritic cells in mice.
    Autoimmunity 2018 Feb 3;51(1):10-17. Epub 2018 Jan 3.
    a Department of Immunology, College of Basic Medical Sciences , Jilin University , Changchun , Jilin , China.
    As a transcription factor, autoimmune regulator (Aire) participates in thymic negative selection and maintains immune tolerance mainly by regulating the ectopic expression of tissue-restricted antigens (TRAs) in medullary thymic epithelial cells (mTECs). Aire is also expressed in dendritic cells (DCs). DCs are professional antigen-presenting cells (APCs) that affect the differentiation of T cells toward distinct subpopulations and participate in the immune response and tolerance, thereby playing an important role in maintaining homeostasis. Read More

    IL-17 and related cytokines involved in systemic sclerosis: Perspectives.
    Autoimmunity 2018 Feb 19;51(1):1-9. Epub 2017 Dec 19.
    b Laboratório de Imunomodulação e Novas Abordagens Terapêuticas Suely Galdino , Universidade Federal de Pernambuco , Recife , Brazil.
    Systemic sclerosis (SSc) is a multisystemic, complex, and rare disease of connective tissue, with high morbidity and mortality, and without specific treatment. The disease is characterized by three main principles: vascular disease, autoantibody production and inflammation, and fibrosis. Since it is well defined that SSc is characterized by elevated production of TGF-β, IL-6, and IL-1, all of them cytokines related to Th17 differentiation, the hypothesis is that this disease may be strongly related to a polarization of the immune response towards the Th17 pathway. Read More

    Polymorphisms and expression of genes encoding Argonautes 1 and 2 in autoimmune thyroid diseases.
    Autoimmunity 2018 Feb 19;51(1):35-42. Epub 2017 Dec 19.
    a Department of Biomedical Informatics, Division of Health Sciences , Osaka University Graduate School of Medicine , Suita , Osaka , Japan.
    The microRNA (miRNA) biogenesis pathway is regulated by specific proteins and enzymes, including Dicer, Drosha, DGCR8, Exportin 5 and the Argonaute (AGO) family. In this study, we investigated the AGO family, which is the primary component of RISC (RNA-induced silencing complex) and directly binds to microRNA. We examined the association of polymorphisms in AGO family genes with AGO expression and with the development and prognosis of autoimmune thyroid diseases. Read More

    The relationship between cell apoptosis dysfunction and FEN1 E160D mutation in lupus nephritis patients.
    Autoimmunity 2017 Dec;50(8):476-480
    a Department of Nephropathy , Lanzhou University Second Hospital , Lanzhou , PR China.
    Objective: This study aims to evaluate the role of FEN1 E160D mutation in lupus nephritis (LN) patients with cell apoptosis dysfunction.

    Methods: (1) Cell apoptosis was detected from 50 paraffin samples obtained from renal biopsies of patients with Class IV LN by TUNEL method and the relationship of the systemic lupus erythematosus disease activity index 2000 (SLEDAI 2000) and renal tissue cell apoptotic index (AI) was discussed. (2) FEN1 gene 61563142-61563342 containing E160D were analysed by extracting genomic DNA from peripheral blood collected from the above 50 LN patients and 25 patients with nephrectomy caused by renal trauma. Read More

    High expression of interleukine-1 receptor antagonist in rheumatoid arthritis: Association with IL1RN*2/2 genotype.
    Autoimmunity 2017 Dec 11;50(8):468-475. Epub 2017 Dec 11.
    a Instituto de Investigación en Ciencias Biomédicas, CUCS , Universidad de Guadalajara , Guadalajara , México.
    Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation and pro-inflammatory cytokines production. IL-1Ra is an anti-inflammatory cytokine codified by IL1RN gene that blocks IL-1 signalling. A VNTR polymorphism of 86 bp in IL1RN gene has been associated with RA risk and regulation of IL-1Ra expression. Read More

    Articular and subcutaneous adipose tissues of rheumatoid arthritis patients represent equal sources of immunoregulatory mesenchymal stem cells.
    Autoimmunity 2017 Dec 6;50(8):441-450. Epub 2017 Dec 6.
    a Department of Pathophysiology and Immunology , National Institute of Geriatrics, Rheumatology and Rehabilitation , Warsaw , Poland.
    Adipose-derived mesenchymal stem cells (ASCs) have immunoregulatory properties, but their activity is dependent on signals provided by the local microenvironment. It is likely that highly inflammatory milieu of rheumatoid joint affects ASCs activity. To test this hypothesis, the function of rheumatoid ASCs derived from articular adipose tissue (AT-ASCs) and ASCs derived from subcutaneous adipose tissue (Sc-ASCs) has been analysed. Read More

    T-cell receptor-mediated characteristic signaling pathway of peripheral blood T cells in dermatomyositis and polymyositis.
    Autoimmunity 2017 Dec 25;50(8):481-490. Epub 2017 Nov 25.
    a Department of Medicine (Neurology and Rheumatology) , Shinshu University School of Medicine , Matsumoto , Japan.
    The characteristics of T cell expression in peripheral blood have been previously described in dermatomyositis (DM) and polymyositis (PM); however, their intracellular signaling profiles remain unknown. The purpose of this study was to investigate the T-cell receptor (TCR)-mediated intracellular signaling in peripheral blood T cells in DM and PM. Peripheral blood T cells from 86 patients with DM (n = 57) and PM (n = 29) were used for experimental investigations. Read More

    Higher frequencies of circulating ICOS, IL-21T follicular helper cells and plasma cells in patients with new-onset membranous nephropathy.
    Autoimmunity 2017 Dec 13;50(8):458-467. Epub 2017 Oct 13.
    a Genetic Diagnosis Center , The First Hospital of Jilin University , Changchun , China.
    Background: T follicular helper (TFH) cells and B cells are known to regulate humoral immune responses. This study is aimed at examining the putative contribution of different subsets of circulating of TFH cells and B cells to membranous nephropathy (MN).

    Methods: A total of 45 MN patients and 19 healthy controls (HCs) were examined for the number of TFH cells and B cells by flow cytometry. Read More

    PTPN22 1858C > T polymorphism and susceptibility to systemic lupus erythematosus: a meta-analysis update.
    Autoimmunity 2017 Nov 8;50(7):428-434. Epub 2017 Oct 8.
    a Laboratory of Immunopathology Keizo Asami (LIKA) , Federal University of Pernambuco , Recife , Brazil.
    Studies performed in the past years showed PTNP22 1858 C > T (rs2476601) polymorphism as associated with systemic lupus erythematosus susceptibility, although conflicting findings are still found. In this context, a powerful statistical study, such as meta-analysis, is necessary to establish a consensus. The aim of this study was to evaluate association studies between the PTPN22 1858 C > T polymorphism and SLE by a meta-analysis update, including three recently published studies in the last three years. Read More

    Fatty infiltration of the minor salivary glands is a selective feature of aging but not Sjögren's syndrome.
    Autoimmunity 2017 Dec 8;50(8):451-457. Epub 2017 Oct 8.
    a Arthritis and Clinical Immunology Program , Oklahoma Medical Research Foundation (OMRF) , Oklahoma City , OK , USA.
    Objective: Determine the presence and assess the extent of fatty infiltration of the minor salivary glands (SG) of primary SS patients (pSS) as compared to those with non-SS sicca (nSS).

    Methods: Minor SG biopsy samples from 134 subjects with pSS (n = 72) or nSS (n = 62) were imaged. Total area and fatty replacement area for each glandular cross-section (n = 4-6 cross-sections per subject) were measured using Image J (National Institutes of Health, Bethesda, MD). Read More

    Expression of activation-induced cytidine deaminase splicing variants in patients with ankylosing spondylitis.
    Autoimmunity 2017 Dec 29;50(8):435-440. Epub 2017 Sep 29.
    a Division of Rheumatology, Department of Medicine , Daejeon Rheumatoid and Degenerative Arthritis Center, Chungnam National University Hospital , Daejeon , Republic of Korea.
    To investigate the expression patterns of activation-induced cytidine deaminase (AID) variants in peripheral blood mononuclear cells (PBMCs) of patients with ankylosing spondylitis (AS) and examine their clinical implications, we isolated PBMCs from healthy controls (HC, n = 33) and patients with AS (n = 62), and measured mRNA expression of AID variants and translesion synthesis (TLS) polymerases using quantitative real-time polymerase chain reaction. The proportion of patients with AS in whom AID splicing variant (sv) 2 was expressed was significantly higher than that of HC (p = .031). Read More

    Interaction analysis between BLK rs13277113 polymorphism and BANK1 rs3733197 polymorphism, MMEL1/TNFRSF14 rs3890745 polymorphism in determining susceptibility to rheumatoid arthritis.
    Autoimmunity 2017 Nov 19;50(7):403-408. Epub 2017 Sep 19.
    a Department of Rheumatology , Ningbo First Hospital, Ningbo Hospital of Zhejiang University , Ningbo , Zhejiang , PR China.
    Two pairwise genetic interactions (B cell lymphocyte kinase (BLK) rs13277113,B cell scaffold protein with ankyrin repeats 1 (BANK1) rs3733197and BLK rs13277113 membrane metalloendopeptidase like 1 (MMEL1)/ tumor necrosis factor receptor superfamily member 14 (TNFRSF14) rs3890745) have been demonstrated in determining susceptibility to rheumatoid arthritis (RA) without replication, thus this study was performed to examine whether abovementioned genetic polymorphisms were associated with RA and further tests were performed to see whether aforementioned genetic interactions existed in RA among Chinese population. A total of 328 patients with RA and 449 healthy control subjects were included in the current study. The polymorphisms were genotyped using the ligase detection reaction-polymerase chain reaction (LDR-PCR) technology. Read More

    Effects of immunomodulators on the response induced by vaccines against autoimmune diseases.
    Autoimmunity 2017 Nov 14;50(7):393-402. Epub 2017 Sep 14.
    a Qantu Therapeutics, Inc , Lewisville , TX , USA.
    A promising treatment for T-cell-mediated autoimmune diseases is the induction of immune tolerance by modulating the immune response against self-antigens, an objective that may be achieved by vaccination. There are two main types of vaccines currently under development. The tolerogenic vaccines, composed of proteins formed by a cytokine fused to a self-antigen, which usually induce tolerance by eliminating the T-cells that are immune reactive against the self-antigen. Read More

    Mannose-binding lectin deficiency and miscarriages in rheumatoid arthritis.
    Autoimmunity 2017 Nov 12;50(7):409-413. Epub 2017 Sep 12.
    a Laboratory of Immunopathology , Clinical Hospital, Federal University of Paraná , Curitiba , Brazil.
    Objective: To investigate the association between mannose-binding lectin (MBL) serum level and MBL2 polymorphisms, and the frequency of spontaneous miscarriages in rheumatoid arthritis (RA) patients.

    Methods: One hundred seventy seven women (mean age 50 years) with RA from Southern Brazil were studied and 4.5% had a history of abortion (8/177). Read More

    Decreased bone mineral density in experimental myasthenia gravis in C57BL/6 mice.
    Autoimmunity 2017 Sep 29;50(6):346-353. Epub 2017 Aug 29.
    a Department of Biochemistry and Molecular Biology , Baylor College of Medicine , Houston , TX , USA.
    Experimental autoimmune myasthenia gravis (EAMG), an animal model of myasthenia gravis (MG), can be induced in C57BL/6 (B6, H-2 ) mice by 2-3 injections with Torpedo californica AChR (tAChR) in complete Freund's adjuvant. Some EAMG mice exhibit weight loss with muscle weakness. The loss in body weight, which is closely associated with bone structure, is particularly evident in EAMG mice with severe muscle weakness. Read More

    KLRG1 expression identifies short-lived Foxp3Teffector cells with functional plasticity in islets of NOD mice.
    Autoimmunity 2017 Sep 29;50(6):354-362. Epub 2017 Aug 29.
    a Department of Microbiology and Immunology , McGill University , Montréal , Québec , Canada.
    A progressive waning in Foxp3regulatory T (T) cell function provokes autoimmunity in the non-obese diabetic (NOD) mouse model of type 1 diabetes (T1D), a cellular defect rescued by prophylactic IL-2 therapy. We showed that most islet-infiltrating Tcells express inducible T-cell co-stimulator (ICOS) in pre-diabetic NOD mice, and that ICOSTcells display enhanced fitness and suppressive function in situ. Moreover, T1D progression is associated with decreased expansion and suppressive activity of ICOSFoxp3Tcells, in islets, an observation consistent with the exacerbated T1D seen in NOD. Read More

    Disease-related autoantibody profile in patients with systemic sclerosis.
    Autoimmunity 2017 Nov 27;50(7):414-421. Epub 2017 Jul 27.
    a Department of Rheumatology and Clinical Immunology , Faculty of Medicine, School of Health Sciences, University of Thessaly , Larissa , Greece.
    Background: Autoantibodies (autoAbs) help in diagnosis and predicting clinical phenotypes in systemic sclerosis (SSc).

    Aim Of The Study: To determine the clinical utility of 13 SSc-related autoAbs in SSc patients.

    Material And Methods: A total of 131 consecutive patients with SSc (111 female, mean age 58. Read More

    Nitration of H2B histone elicits an immune response in experimental animals.
    Autoimmunity 2017 Jun 24;50(4):232-240. Epub 2017 Jul 24.
    a Department of Biosciences , Jamia Millia Islamia , New Delhi , India.
    Histone H2B is an autoantigen that appears in circulation due to altered apoptosis/or insufficient clearance and is likely to be involved in the induction and progression of autoimmune diseases since modified-H2B is immunogenic. Our studies demonstrate that tyrosines of H2B histone spontaneously converts to free and nitrotyrosine bound protein in vivo. Commercially available H2B histone was modified with peroxynitrite in vitro. Read More

    Immunization of BALB/c mice with pigeon IgY induces the production of anti-IgG autoantibodies.
    Autoimmunity 2017 Sep 12;50(6):336-345. Epub 2017 Jul 12.
    b Laboratorio de Autoinmunidad , Unidad de Investigación INER , México City , México.
    The breakdown of immunological tolerance due to the activation of autoreactive B and T cells triggers physiopathological processes. An example of such conditions is the production of IgG autoantibodies specific for the Fc portion of IgG (anti-Fcγ IgG). Previous reports have shown that patients with pigeon-related hypersensitivity pneumonitis exhibit an increase in the serum levels of anti-Fcγ IgG. Read More

    Management of hydrocephalus associated with autoimmune diseases: a series of 19 cases.
    Autoimmunity 2017 Nov 7;50(7):422-427. Epub 2017 Jul 7.
    a The Department of Neurosurgery , Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , P.R. China.
    Objectives: To analyze the diagnosis and treatment of hydrocephalus associated with autoimmune diseases and to explore the possible mechanism of hydrocephalus in these patients.

    Methods: A retrospective case series study was conducted at Peking Union Medical College Hospital, Beijing, China. Files were retrieved from the hospital archives by screening records from Jan 1990 to Jan 2016. Read More

    Contribution of both B-cell intrinsic alterations as well as non-hematopoietic-derived factors in the enhanced immune response of the NOD mouse.
    Autoimmunity 2017 Sep 7;50(6):363-369. Epub 2017 Jul 7.
    a Department of Clinical Microbiology, Division of Immunology , Umeå University , Umeå , Sweden.
    The underlying cellular and molecular mechanism for the development of Type 1 diabetes is still to be fully revealed. We have previously demonstrated that the NOD mouse, a model for Type 1 diabetes, display a prolonged and enhanced immune response to both self and non-self-antigens. The molecular explanation for this defect however, has not been determined. Read More

    Impaired salivary gland activity in patients with autoimmune polyendocrine syndrome type I.
    Autoimmunity 2017 Jun 7;50(4):211-222. Epub 2017 Jul 7.
    a Department of Clinical Science , University of Bergen , Bergen , Norway.
    Autoimmune polyendocrine syndrome type I (APS-I) is a severe disease caused by mutations in the autoimmune regulator (AIRE) gene. We hypothesized that salivary gland dysfunction could be a possible unexplored component of these patients and here aimed to investigate salivary and lachrymal symptoms in the Norwegian cohort of APS-I patients (N = 41) and the aetiology behind it. Sicca symptoms and possible corresponding underlying factors were assessed by subjective reports combined with objective measures of saliva and tear flow, serological testing, immune fluorescence microscopy, ultrasonography and searching for putative autoantibodies in the salivary glands. Read More

    Caerulomycin A suppresses the differentiation of naïve T cells and alleviates the symptoms of experimental autoimmune encephalomyelitis.
    Autoimmunity 2017 Aug 7;50(5):317-328. Epub 2017 Jul 7.
    a Immunology Laboratory , CSIR-Institute of Microbial Technology , Chandigarh , India.
    Multiple sclerosis (MS) is a highly detrimental autoimmune disease of the central nervous system. There is no cure for it but the treatment typically focuses on subsiding severity and recurrence of the disease. Experimental autoimmune encephalomyelitis (EAE) is an animal model of MS. Read More

    Kinase inhibitors of the IGF-1R as a potential therapeutic agent for rheumatoid arthritis.
    Autoimmunity 2017 Aug 6;50(5):329-335. Epub 2017 Jul 6.
    b Department of Internal Medicine and Rheumatology, School of Medicine , Juntendo University , Tokyo , Japan.
    We have previously shown that the inhibition of connective tissue growth factor (CTGF) is a potential therapeutic strategy against rheumatoid arthritis (RA). CTGF consists of four distinct modules, including the insulin-like growth factor binding protein (IGFBP). In serum, insulin-like growth factors (IGFs) bind IGFBPs, interact with the IGF-1 receptor (IGF-1 R), and regulate anabolic effects and bone metabolism. Read More

    Identification of potential biomarkers for systemic lupus erythematosus diagnosis using two-dimensional differential gel electrophoresis (2D-DIGE) and mass spectrometry.
    Autoimmunity 2017 Jun 4;50(4):247-256. Epub 2017 Jul 4.
    a Department of Clinical and Toxicological Analysis, Faculty of Pharmacy , Universidade Federal de Minas Gerais , Belo Horizonte , Minas Gerais , Brazil.
    Systemic lupus erythematosus (SLE) is an autoimmune disease of the connective tissue with a large spectrum of clinical manifestations. Immune deregulation leads to autoantibody and immune complexes overproduction, complement activation, and persistent tissue inflammation. Considering that the current diagnosis depends on the interpretation of the complex criteria established by the American College of Rheumatology and that the disease course is characterized by unpredictable activations and remissions, each patient develops different manifestations, and therefore, the discovery of specific biomarkers is urgently required. Read More

    Association of the polymorphisms in the gene encoding thyroglobulin with the development and prognosis of autoimmune thyroid disease.
    Autoimmunity 2017 Sep 4;50(6):386-392. Epub 2017 Jul 4.
    a Department of Biomedical Informatics, Division of Health Sciences , Osaka University Graduate School of Medicine , Osaka , Japan.
    Graves' disease (GD) and Hashimoto's disease (HD) are autoimmune thyroid diseases (AITDs), and the prognosis of AITDs is different for each patient. We examined the association of polymorphisms in the Thyroglobulin (TG) gene with the pathogenesis of AITD. We genotyped TG rs180195G/A, rs853326G/A, rs2076740C/T, rs2703013G/T, rs2958692C/T and rs733735A/G polymorphisms in 137 HD patients, 131 GD patients and 89 healthy controls and also examined the levels of TG mRNA expression and serum TG. Read More

    Modification of anti-tumor immunity by tolerogenic dendritic cells.
    Autoimmunity 2017 Sep 4;50(6):370-376. Epub 2017 Jul 4.
    b Department of Biosciences and Nutrition , Karolinska Institutet , Novum, Huddinge , Sweden.
    Immunosuppressive functions of glucocorticoids (GC) can be mediated via various mechanisms, including the modulation of dendritic cells (DC). Our study investigates the effects of tolerogenic GC-treated DCs on NK and T cell anti-tumor responses in OT-1/Ragmice, expressing a transgenic TCR in CD8T cells. The effects caused by GC-treated DCs were compared to the responses to immunogenic, CpG-activated DCs. Read More

    Sex-related differences in autoimmune-induced lung lesions in MRL/MpJ-fasmice are mediated by the development of mediastinal fat-associated lymphoid clusters.
    Autoimmunity 2017 Aug 30;50(5):306-316. Epub 2017 Jun 30.
    b Laboratory of Anatomy, Department of Biomedical Sciences, Graduate School of Veterinary Medicine , Hokkaido University , Sapporo , Japan.
    MRL/MpJ-Fas(lpr) mice are a model for autoimmune diseases such as systemic lupus erythematosus (SLE). These diseases mainly affect women, with a 10:1 female-to-male ratio, and cause pleuropulmonary lesions. We previously revealed a correlation between mediastinal fat-associated lymphoid cluster (MFALC) development and cellular infiltration in the lungs of lpr male mice; however, we did not report on MFALCs in females. Read More

    Abnormal distribution of AQP4 in minor salivary glands of primary Sjögren's syndrome patients.
    Autoimmunity 2017 Jun 24;50(4):202-210. Epub 2017 Jun 24.
    a Department of Basic Medical Sciences, Neurosciences and Sensory Organs (SMBNOS), Section of Human Anatomy and Histology , University of Bari "Aldo Moro" , Bari , Italy.
    A decreased saliva production occurs in primary Sjögren's syndrome (pSS), an autoimmune disease characterized by oral and ocular dryness due to dysfunction of the lacrimal and salivary glands (SGs). Since water movement is involved in saliva secretion, the expression, localization, and function of the water channels aquaporins (AQPs) have been extensively studied in SGs. To date, the presence of AQP4 remains controversial and ambiguous in human SGs. Read More

    Identification of endothelin-converting enzyme-2 as an autoantigen in autoimmune polyendocrine syndrome type 1.
    Autoimmunity 2017 Jun 30;50(4):223-231. Epub 2017 May 30.
    a Department of Medical Sciences , Uppsala University , Uppsala , Sweden.
    Autoimmune polyendocrine syndrome type 1 (APS1) is a rare monogenic autoimmune disorder caused by mutations in the autoimmune regulator (AIRE) gene. High titer autoantibodies are a characteristic feature of APS1 and are often associated with particular disease manifestations. Pituitary deficits are reported in up to 7% of all APS1 patients, with immunoreactivity to pituitary tissue frequently reported. Read More

    Antiribonuclease H2 antibodies are an immune biomarker for systemic lupus erythematosus.
    Autoimmunity 2017 Jun 27;50(4):241-246. Epub 2017 May 27.
    a Department of Rheumatology , Juntendo University School of Medicine , Tokyo , Japan.
    We previously reported that autoantibodies against the proliferating cell nuclear antigen protein (PCNA)-binding protein chromatin assembly factor-1 (CAF-1) are specifically found in patients with systemic lupus erythematosus (SLE). PCNA and its complex constituents elicit autoimmune responses in patients with SLE, suggesting that autoantibody diversification likely occurs owing to epitope spreading. Therefore, we sought to clarify whether patients with SLE exhibit an autoimmune response to Ribonuclease H2 (RNase H2), another PCNA-binding protein that regulates cell division. Read More

    Injection of inactive Bordetella pertussis and complete Freund's adjuvant with Torpedo californica AChR increases the occurrence of experimental autoimmune myasthenia gravis in C57BL/6 mice.
    Autoimmunity 2017 Aug 26;50(5):293-305. Epub 2017 May 26.
    a Department of Biochemistry and Molecular Biology , Baylor College of Medicine , Houston , TX , USA.
    An animal model of myasthenia gravis (MG), termed experimental autoimmune MG (EAMG), is an important tool for investigations of disease mechanisms and/or methods of treatment for this disease. EAMG can be induced in C57BL/6 (B6, H-2) mice by 2-3 times injections at 4 weeks intervals with Torpedo californica (t) acetylcholine receptor (AChR) in complete Freund's adjuvant (CFA). However, the protocol especially with a two-injection schedule occasionally produces a poor incidence of EAMG. Read More

    CD59 polymorphisms are associated with gene expression and different sexual susceptibility to pemphigus foliaceus.
    Autoimmunity 2017 Sep 23;50(6):377-385. Epub 2017 May 23.
    a Laboratory of Human Molecular Genetics, Department of Genetics , Universidade Federal do Paraná , Curitiba , Brazil.
    Pemphigus foliaceus (PF) is an autoimmune disease, endemic in Brazilian rural areas, characterized by acantholysis and accompanied by complement activation, with generalized or localized distribution of painful epidermal blisters. CD59 is an essential complement regulator, inhibiting formation of the membrane attack complex, and mediating signal transduction and activation of T lymphocytes. CD59 has different transcripts by alternative splicing, of which only two are widely expressed, suggesting the presence of regulatory sites in their noncoding regions. Read More

    Genotype and haplotype analysis of ABCB1 at 1236, 2677 and 3435 among systemic sclerosis patients.
    Autoimmunity 2017 Aug 23;50(5):277-282. Epub 2017 May 23.
    b Department of Dermatology and Venereology, Chair of Dermatology and Venereology , Medical University of Lodz , Łódź, Poland.
    Systemic sclerosis (SSc) belongs to the group of systemic diseases of the connective tissue, which are characterized by a chronic autoimmune inflammatory process. P-glycoprotein, initially associated with the drug resistance in patients with cancer, becomes more and more often a subject of considerations in terms of its significance in the development of illnesses, including autoimmune diseases. The aim of the study was an attempt to answer the question whether there was a relationship between ABCB1 polymorphisms and morbidity of systemic sclerosis in a Polish population. Read More

    Adipose tissue infiltration in minor salivary glands of patients with Sjögren's syndrome: Lack of significant correlation with the disease. An image analysis of 174 cases.
    Autoimmunity 2017 Jun 23;50(4):199-201. Epub 2017 Apr 23.
    a Department of Pathology, Oral Pathology Unit , Medical School and Clinical Center, Pécs University , Pecs, Hungary.
    Fatty infiltration in minor salivary gland biopsies and its correlation to systemic autoimmune diseases are controversial in the literature. Presence and extent of fatty infiltration in minor salivary glands of 107 Sjögren's syndrome patients and 67 age-matched sicca controls were compared with statistical analyses. No significant difference was found regarding the presence or the extent of fatty infiltration between the two groups. Read More

    Decreased TLR4 expression on monocytes may cause regulatory T cells abnormality in patients with primary immune thrombocytopenia.
    Autoimmunity 2017 Aug 17;50(5):283-292. Epub 2017 Apr 17.
    a State Key Laboratory of Experimental Hematology , Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College , Tianjin , PR China.
    Primary immune thrombocytopenia (ITP) is an autoimmune disease with many immune dysfunctions including T helper type 1 cell (Th1) polarization and regulatory T cells (Tregs) deficiency. This study aimed to determine the effects of TLR4 on Treg differentiation and the cytokine production of peripheral blood mononuclear cells (PBMCs) from patients with ITP. We found that expression of TLR4 on monocytes was significantly decreased in patients with active ITP than that in healthy controls and it had positive correlation with platelet count. Read More

    Is autoimmunology a discipline of its own? A big data-based bibliometric and scientometric analyses.
    Autoimmunity 2017 Jun 23;50(4):269-274. Epub 2017 Mar 23.
    b Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center , Tel- Hashomer, Israel.
    Autoimmunology is a super-specialty of immunology specifically dealing with autoimmune disorders. To assess the extant literature concerning autoimmune disorders, bibliometric and scientometric analyses (namely, research topics/keywords co-occurrence, journal co-citation, citations, and scientific output trends - both crude and normalized, authors network, leading authors, countries, and organizations analysis) were carried out using open-source software, namely, VOSviewer and SciCurve. A corpus of 169,519 articles containing the keyword "autoimmunity" was utilized, selecting PubMed/MEDLINE as bibliographic thesaurus. Read More

    Annexin A1 as a target for managing murine pristane-induced systemic lupus erythematosus.
    Autoimmunity 2017 Jun 16;50(4):257-268. Epub 2017 Mar 16.
    a Laboratory of Experimental Immunology, Institute of Microbiology, Bulgarian Academy of Sciences , Sofia , Bulgaria.
    Systemic lupus erythematosus (SLE) is a polygenic pathological disorder which involves multiple organs. Self-specific B cells play a main role in the lupus pathogenesis by generating autoantibodies as well as by serving as important autoantigen-presenting cells. Autoreactive T lymphocytes, on the other hand, are responsible for B cell activation and proliferation, and cytokine production. Read More

    Complex interaction between HNRNPD mutations and risk polymorphisms is associated with discordant Crohn's disease in monozygotic twins.
    Autoimmunity 2017 Aug 16;50(5):275-276. Epub 2017 Mar 16.
    a Genetics and Genomics Lab, Department of Studies in Genetics and Genomics , University of Mysore , Mysuru , India.
    Crohn's disease (CD) is a chronic inflammatory bowel disease (IBD) affecting the lining of digestive tracts of the colon and ileum. To investigate the reasons behind the presence of CD phenotype in one of the monozygotic (MZ) twins, we utilized the whole exome sequence (WES) datasets of CD tissue biopsy and CD blood of affected twin and the exome dataset of blood from healthy twin. We report the presence of discordant and rare damaging mutation in HNRNPD and other risk polymorphisms such as, rs12103, rs2241880, rs3810936, rs7076156, rs1042058 and rs1292053. Read More

    Inflammation in Sjögren's syndrome: Cause or consequence?
    Autoimmunity 2017 May 14;50(3):141-150. Epub 2017 Feb 14.
    a Department of Biochemistry , Faculty of Medicine, University of Porto , Porto , Portugal and.
    Sjögren's syndrome (SS) is an autoimmune disease most commonly characterized by ocular and oral dryness. Despite the high prevalence of SS, generation and perpetuation of this disease is still unclear in many aspects. Inflammation, nonetheless, seems to play a central role in this pathology especially in the form of Th-1, Th-2 and Th-17 cytokines release within different aspects, concentrations and connections involved in the maintenance of the syndrome. Read More

    Diagnostic significance of serum concentrations of soluble Fas ligand (sFasL) in children with autoimmune thyroid disease.
    Autoimmunity 2017 May 21;50(3):192-198. Epub 2017 Feb 21.
    a Department of Pediatric Endocrinology and Rheumatology and.
    Introduction: The aim of the study was to assess serum levels of sFasL as a marker of thyroid dysfunction in children with autoimmune thyroid disease (AITD).

    Design: The group comprised 45 newly diagnosed children with Hashimoto's thyroiditis and Graves' disease versus euthyroid control group: 11 with hypothyroidism (10 girls and 1 boy, aged 12.2 ± 1. Read More

    Aberrant function of myeloid-derived suppressor cells (MDSCs) in experimental colitis and in inflammatory bowel disease (IBD) immune responses.
    Autoimmunity 2017 May 3;50(3):170-181. Epub 2017 Mar 3.
    d Division of Clinical , Experimental Surgery, & Translational Research, Biomedical Research Foundation of the Academy of Athens , Athens , Greece.
    Background And Aims: Myeloid-derived suppressor cells (MDSCs) encompass a novel population of suppressor cells and a potential candidate for cell-based therapies in inflammatory diseases. Herein, we investigated their immunomodulatory properties in experimental inflammatory colitis and T cell-mediated immune responses in inflammatory bowel disease (IBD) patients.

    Methods: MDSCs (defined as CD14HLADRCD33CD15) numbers were determined in peripheral blood (PB) from IBD patients. Read More

    Decreased serum DNase1-activity in patients with autoimmune liver diseases.
    Autoimmunity 2017 Mar 14;50(2):125-132. Epub 2017 Feb 14.
    a Department of Medicine and Research Laboratory of Internal Medicine , School of Medicine, University of Thessaly , Larissa , Greece.
    Deoxyribonuclease1 (DNase1) is involved in chromatin degradation of apoptotic cells. Its deficiency results in accumulation of self-DNA, which in turn may induce inflammation and autoimmunity. We assessed for the first time serum DNase1-activity in a large consecutive cohort of treatment-naïve patients with autoimmune liver diseases (ALD). Read More

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