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    2388 results match your criteria Autoimmunity [Journal]

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    Higher frequencies of circulating ICOS(+), IL-21(+) T follicular helper cells and plasma cells in patients with new-onset membranous nephropathy.
    Autoimmunity 2017 Oct 13:1-10. Epub 2017 Oct 13.
    a Genetic Diagnosis Center , The First Hospital of Jilin University , Changchun , China.
    Background: T follicular helper (TFH) cells and B cells are known to regulate humoral immune responses. This study is aimed at examining the putative contribution of different subsets of circulating of TFH cells and B cells to membranous nephropathy (MN).

    Methods: A total of 45 MN patients and 19 healthy controls (HCs) were examined for the number of TFH cells and B cells by flow cytometry. Read More

    PTPN22 1858C > T polymorphism and susceptibility to systemic lupus erythematosus: a meta-analysis update.
    Autoimmunity 2017 Nov 8;50(7):428-434. Epub 2017 Oct 8.
    a Laboratory of Immunopathology Keizo Asami (LIKA) , Federal University of Pernambuco , Recife , Brazil.
    Studies performed in the past years showed PTNP22 1858 C > T (rs2476601) polymorphism as associated with systemic lupus erythematosus susceptibility, although conflicting findings are still found. In this context, a powerful statistical study, such as meta-analysis, is necessary to establish a consensus. The aim of this study was to evaluate association studies between the PTPN22 1858 C > T polymorphism and SLE by a meta-analysis update, including three recently published studies in the last three years. Read More

    Fatty infiltration of the minor salivary glands is a selective feature of aging but not Sjögren's syndrome.
    Autoimmunity 2017 Oct 8:1-7. Epub 2017 Oct 8.
    a Arthritis and Clinical Immunology Program , Oklahoma Medical Research Foundation (OMRF) , Oklahoma City , OK , USA.
    Objective: Determine the presence and assess the extent of fatty infiltration of the minor salivary glands (SG) of primary SS patients (pSS) as compared to those with non-SS sicca (nSS).

    Methods: Minor SG biopsy samples from 134 subjects with pSS (n = 72) or nSS (n = 62) were imaged. Total area and fatty replacement area for each glandular cross-section (n = 4-6 cross-sections per subject) were measured using Image J (National Institutes of Health, Bethesda, MD). Read More

    Expression of activation-induced cytidine deaminase splicing variants in patients with ankylosing spondylitis.
    Autoimmunity 2017 Sep 29:1-6. Epub 2017 Sep 29.
    a Division of Rheumatology, Department of Medicine , Daejeon Rheumatoid and Degenerative Arthritis Center, Chungnam National University Hospital , Daejeon , Republic of Korea.
    To investigate the expression patterns of activation-induced cytidine deaminase (AID) variants in peripheral blood mononuclear cells (PBMCs) of patients with ankylosing spondylitis (AS) and examine their clinical implications, we isolated PBMCs from healthy controls (HC, n = 33) and patients with AS (n = 62), and measured mRNA expression of AID variants and translesion synthesis (TLS) polymerases using quantitative real-time polymerase chain reaction. The proportion of patients with AS in whom AID splicing variant (sv) 2 was expressed was significantly higher than that of HC (p = .031). Read More

    Interaction analysis between BLK rs13277113 polymorphism and BANK1 rs3733197 polymorphism, MMEL1/TNFRSF14 rs3890745 polymorphism in determining susceptibility to rheumatoid arthritis.
    Autoimmunity 2017 Nov 19;50(7):403-408. Epub 2017 Sep 19.
    a Department of Rheumatology , Ningbo First Hospital, Ningbo Hospital of Zhejiang University , Ningbo , Zhejiang , PR China.
    Two pairwise genetic interactions (B cell lymphocyte kinase (BLK) rs13277113,B cell scaffold protein with ankyrin repeats 1 (BANK1) rs3733197and BLK rs13277113 membrane metalloendopeptidase like 1 (MMEL1)/ tumor necrosis factor receptor superfamily member 14 (TNFRSF14) rs3890745) have been demonstrated in determining susceptibility to rheumatoid arthritis (RA) without replication, thus this study was performed to examine whether abovementioned genetic polymorphisms were associated with RA and further tests were performed to see whether aforementioned genetic interactions existed in RA among Chinese population. A total of 328 patients with RA and 449 healthy control subjects were included in the current study. The polymorphisms were genotyped using the ligase detection reaction-polymerase chain reaction (LDR-PCR) technology. Read More

    Effects of immunomodulators on the response induced by vaccines against autoimmune diseases.
    Autoimmunity 2017 Nov 14;50(7):393-402. Epub 2017 Sep 14.
    a Qantu Therapeutics, Inc , Lewisville , TX , USA.
    A promising treatment for T-cell-mediated autoimmune diseases is the induction of immune tolerance by modulating the immune response against self-antigens, an objective that may be achieved by vaccination. There are two main types of vaccines currently under development. The tolerogenic vaccines, composed of proteins formed by a cytokine fused to a self-antigen, which usually induce tolerance by eliminating the T-cells that are immune reactive against the self-antigen. Read More

    Mannose-binding lectin deficiency and miscarriages in rheumatoid arthritis.
    Autoimmunity 2017 Nov 12;50(7):409-413. Epub 2017 Sep 12.
    a Laboratory of Immunopathology , Clinical Hospital, Federal University of Paraná , Curitiba , Brazil.
    Objective: To investigate the association between mannose-binding lectin (MBL) serum level and MBL2 polymorphisms, and the frequency of spontaneous miscarriages in rheumatoid arthritis (RA) patients.

    Methods: One hundred seventy seven women (mean age 50 years) with RA from Southern Brazil were studied and 4.5% had a history of abortion (8/177). Read More

    Decreased bone mineral density in experimental myasthenia gravis in C57BL/6 mice.
    Autoimmunity 2017 Sep 29;50(6):346-353. Epub 2017 Aug 29.
    a Department of Biochemistry and Molecular Biology , Baylor College of Medicine , Houston , TX , USA.
    Experimental autoimmune myasthenia gravis (EAMG), an animal model of myasthenia gravis (MG), can be induced in C57BL/6 (B6, H-2 (b)) mice by 2-3 injections with Torpedo californica AChR (tAChR) in complete Freund's adjuvant. Some EAMG mice exhibit weight loss with muscle weakness. The loss in body weight, which is closely associated with bone structure, is particularly evident in EAMG mice with severe muscle weakness. Read More

    KLRG1 expression identifies short-lived Foxp3(+) Treg effector cells with functional plasticity in islets of NOD mice.
    Autoimmunity 2017 Sep 29;50(6):354-362. Epub 2017 Aug 29.
    a Department of Microbiology and Immunology , McGill University , Montréal , Québec , Canada.
    A progressive waning in Foxp3(+) regulatory T (Treg) cell function provokes autoimmunity in the non-obese diabetic (NOD) mouse model of type 1 diabetes (T1D), a cellular defect rescued by prophylactic IL-2 therapy. We showed that most islet-infiltrating Treg cells express inducible T-cell co-stimulator (ICOS) in pre-diabetic NOD mice, and that ICOS(+) Treg cells display enhanced fitness and suppressive function in situ. Moreover, T1D progression is associated with decreased expansion and suppressive activity of ICOS(+)Foxp3(+) Treg cells, in islets, an observation consistent with the exacerbated T1D seen in NOD. Read More

    Disease-related autoantibody profile in patients with systemic sclerosis.
    Autoimmunity 2017 Nov 27;50(7):414-421. Epub 2017 Jul 27.
    a Department of Rheumatology and Clinical Immunology , Faculty of Medicine, School of Health Sciences, University of Thessaly , Larissa , Greece.
    Background: Autoantibodies (autoAbs) help in diagnosis and predicting clinical phenotypes in systemic sclerosis (SSc).

    Aim Of The Study: To determine the clinical utility of 13 SSc-related autoAbs in SSc patients.

    Material And Methods: A total of 131 consecutive patients with SSc (111 female, mean age 58. Read More

    Nitration of H2B histone elicits an immune response in experimental animals.
    Autoimmunity 2017 Jun 24;50(4):232-240. Epub 2017 Jul 24.
    a Department of Biosciences , Jamia Millia Islamia , New Delhi , India.
    Histone H2B is an autoantigen that appears in circulation due to altered apoptosis/or insufficient clearance and is likely to be involved in the induction and progression of autoimmune diseases since modified-H2B is immunogenic. Our studies demonstrate that tyrosines of H2B histone spontaneously converts to free and nitrotyrosine bound protein in vivo. Commercially available H2B histone was modified with peroxynitrite in vitro. Read More

    Immunization of BALB/c mice with pigeon IgY induces the production of anti-IgG autoantibodies.
    Autoimmunity 2017 Sep 12;50(6):336-345. Epub 2017 Jul 12.
    b Laboratorio de Autoinmunidad , Unidad de Investigación INER , México City , México.
    The breakdown of immunological tolerance due to the activation of autoreactive B and T cells triggers physiopathological processes. An example of such conditions is the production of IgG autoantibodies specific for the Fc portion of IgG (anti-Fcγ IgG). Previous reports have shown that patients with pigeon-related hypersensitivity pneumonitis exhibit an increase in the serum levels of anti-Fcγ IgG. Read More

    Management of hydrocephalus associated with autoimmune diseases: a series of 19 cases.
    Autoimmunity 2017 Nov 7;50(7):422-427. Epub 2017 Jul 7.
    a The Department of Neurosurgery , Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , P.R. China.
    Objectives: To analyze the diagnosis and treatment of hydrocephalus associated with autoimmune diseases and to explore the possible mechanism of hydrocephalus in these patients.

    Methods: A retrospective case series study was conducted at Peking Union Medical College Hospital, Beijing, China. Files were retrieved from the hospital archives by screening records from Jan 1990 to Jan 2016. Read More

    Contribution of both B-cell intrinsic alterations as well as non-hematopoietic-derived factors in the enhanced immune response of the NOD mouse.
    Autoimmunity 2017 Sep 7;50(6):363-369. Epub 2017 Jul 7.
    a Department of Clinical Microbiology, Division of Immunology , Umeå University , Umeå , Sweden.
    The underlying cellular and molecular mechanism for the development of Type 1 diabetes is still to be fully revealed. We have previously demonstrated that the NOD mouse, a model for Type 1 diabetes, display a prolonged and enhanced immune response to both self and non-self-antigens. The molecular explanation for this defect however, has not been determined. Read More

    Impaired salivary gland activity in patients with autoimmune polyendocrine syndrome type I.
    Autoimmunity 2017 Jun 7;50(4):211-222. Epub 2017 Jul 7.
    a Department of Clinical Science , University of Bergen , Bergen , Norway.
    Autoimmune polyendocrine syndrome type I (APS-I) is a severe disease caused by mutations in the autoimmune regulator (AIRE) gene. We hypothesized that salivary gland dysfunction could be a possible unexplored component of these patients and here aimed to investigate salivary and lachrymal symptoms in the Norwegian cohort of APS-I patients (N = 41) and the aetiology behind it. Sicca symptoms and possible corresponding underlying factors were assessed by subjective reports combined with objective measures of saliva and tear flow, serological testing, immune fluorescence microscopy, ultrasonography and searching for putative autoantibodies in the salivary glands. Read More

    Caerulomycin A suppresses the differentiation of naïve T cells and alleviates the symptoms of experimental autoimmune encephalomyelitis.
    Autoimmunity 2017 Aug 7;50(5):317-328. Epub 2017 Jul 7.
    a Immunology Laboratory , CSIR-Institute of Microbial Technology , Chandigarh , India.
    Multiple sclerosis (MS) is a highly detrimental autoimmune disease of the central nervous system. There is no cure for it but the treatment typically focuses on subsiding severity and recurrence of the disease. Experimental autoimmune encephalomyelitis (EAE) is an animal model of MS. Read More

    Kinase inhibitors of the IGF-1R as a potential therapeutic agent for rheumatoid arthritis.
    Autoimmunity 2017 Aug 6;50(5):329-335. Epub 2017 Jul 6.
    b Department of Internal Medicine and Rheumatology, School of Medicine , Juntendo University , Tokyo , Japan.
    We have previously shown that the inhibition of connective tissue growth factor (CTGF) is a potential therapeutic strategy against rheumatoid arthritis (RA). CTGF consists of four distinct modules, including the insulin-like growth factor binding protein (IGFBP). In serum, insulin-like growth factors (IGFs) bind IGFBPs, interact with the IGF-1 receptor (IGF-1 R), and regulate anabolic effects and bone metabolism. Read More

    Identification of potential biomarkers for systemic lupus erythematosus diagnosis using two-dimensional differential gel electrophoresis (2D-DIGE) and mass spectrometry.
    Autoimmunity 2017 Jun 4;50(4):247-256. Epub 2017 Jul 4.
    a Department of Clinical and Toxicological Analysis, Faculty of Pharmacy , Universidade Federal de Minas Gerais , Belo Horizonte , Minas Gerais , Brazil.
    Systemic lupus erythematosus (SLE) is an autoimmune disease of the connective tissue with a large spectrum of clinical manifestations. Immune deregulation leads to autoantibody and immune complexes overproduction, complement activation, and persistent tissue inflammation. Considering that the current diagnosis depends on the interpretation of the complex criteria established by the American College of Rheumatology and that the disease course is characterized by unpredictable activations and remissions, each patient develops different manifestations, and therefore, the discovery of specific biomarkers is urgently required. Read More

    Association of the polymorphisms in the gene encoding thyroglobulin with the development and prognosis of autoimmune thyroid disease.
    Autoimmunity 2017 Sep 4;50(6):386-392. Epub 2017 Jul 4.
    a Department of Biomedical Informatics, Division of Health Sciences , Osaka University Graduate School of Medicine , Osaka , Japan.
    Graves' disease (GD) and Hashimoto's disease (HD) are autoimmune thyroid diseases (AITDs), and the prognosis of AITDs is different for each patient. We examined the association of polymorphisms in the Thyroglobulin (TG) gene with the pathogenesis of AITD. We genotyped TG rs180195G/A, rs853326G/A, rs2076740C/T, rs2703013G/T, rs2958692C/T and rs733735A/G polymorphisms in 137 HD patients, 131 GD patients and 89 healthy controls and also examined the levels of TG mRNA expression and serum TG. Read More

    Modification of anti-tumor immunity by tolerogenic dendritic cells.
    Autoimmunity 2017 Sep 4;50(6):370-376. Epub 2017 Jul 4.
    b Department of Biosciences and Nutrition , Karolinska Institutet , Novum, Huddinge , Sweden.
    Immunosuppressive functions of glucocorticoids (GC) can be mediated via various mechanisms, including the modulation of dendritic cells (DC). Our study investigates the effects of tolerogenic GC-treated DCs on NK and T cell anti-tumor responses in OT-1/Rag(-/-) mice, expressing a transgenic TCR in CD8(+) T cells. The effects caused by GC-treated DCs were compared to the responses to immunogenic, CpG-activated DCs. Read More

    Sex-related differences in autoimmune-induced lung lesions in MRL/MpJ-fas(lpr) mice are mediated by the development of mediastinal fat-associated lymphoid clusters.
    Autoimmunity 2017 Aug 30;50(5):306-316. Epub 2017 Jun 30.
    b Laboratory of Anatomy, Department of Biomedical Sciences, Graduate School of Veterinary Medicine , Hokkaido University , Sapporo , Japan.
    MRL/MpJ-Fas(lpr) (lpr) mice are a model for autoimmune diseases such as systemic lupus erythematosus (SLE). These diseases mainly affect women, with a 10:1 female-to-male ratio, and cause pleuropulmonary lesions. We previously revealed a correlation between mediastinal fat-associated lymphoid cluster (MFALC) development and cellular infiltration in the lungs of lpr male mice; however, we did not report on MFALCs in females. Read More

    Abnormal distribution of AQP4 in minor salivary glands of primary Sjögren's syndrome patients.
    Autoimmunity 2017 Jun 24;50(4):202-210. Epub 2017 Jun 24.
    a Department of Basic Medical Sciences, Neurosciences and Sensory Organs (SMBNOS), Section of Human Anatomy and Histology , University of Bari "Aldo Moro" , Bari , Italy.
    A decreased saliva production occurs in primary Sjögren's syndrome (pSS), an autoimmune disease characterized by oral and ocular dryness due to dysfunction of the lacrimal and salivary glands (SGs). Since water movement is involved in saliva secretion, the expression, localization, and function of the water channels aquaporins (AQPs) have been extensively studied in SGs. To date, the presence of AQP4 remains controversial and ambiguous in human SGs. Read More

    Identification of endothelin-converting enzyme-2 as an autoantigen in autoimmune polyendocrine syndrome type 1.
    Autoimmunity 2017 Jun 30;50(4):223-231. Epub 2017 May 30.
    a Department of Medical Sciences , Uppsala University , Uppsala , Sweden.
    Autoimmune polyendocrine syndrome type 1 (APS1) is a rare monogenic autoimmune disorder caused by mutations in the autoimmune regulator (AIRE) gene. High titer autoantibodies are a characteristic feature of APS1 and are often associated with particular disease manifestations. Pituitary deficits are reported in up to 7% of all APS1 patients, with immunoreactivity to pituitary tissue frequently reported. Read More

    Antiribonuclease H2 antibodies are an immune biomarker for systemic lupus erythematosus.
    Autoimmunity 2017 Jun 27;50(4):241-246. Epub 2017 May 27.
    a Department of Rheumatology , Juntendo University School of Medicine , Tokyo , Japan.
    We previously reported that autoantibodies against the proliferating cell nuclear antigen protein (PCNA)-binding protein chromatin assembly factor-1 (CAF-1) are specifically found in patients with systemic lupus erythematosus (SLE). PCNA and its complex constituents elicit autoimmune responses in patients with SLE, suggesting that autoantibody diversification likely occurs owing to epitope spreading. Therefore, we sought to clarify whether patients with SLE exhibit an autoimmune response to Ribonuclease H2 (RNase H2), another PCNA-binding protein that regulates cell division. Read More

    Injection of inactive Bordetella pertussis and complete Freund's adjuvant with Torpedo californica AChR increases the occurrence of experimental autoimmune myasthenia gravis in C57BL/6 mice.
    Autoimmunity 2017 Aug 26;50(5):293-305. Epub 2017 May 26.
    a Department of Biochemistry and Molecular Biology , Baylor College of Medicine , Houston , TX , USA.
    An animal model of myasthenia gravis (MG), termed experimental autoimmune MG (EAMG), is an important tool for investigations of disease mechanisms and/or methods of treatment for this disease. EAMG can be induced in C57BL/6 (B6, H-2(b)) mice by 2-3 times injections at 4 weeks intervals with Torpedo californica (t) acetylcholine receptor (AChR) in complete Freund's adjuvant (CFA). However, the protocol especially with a two-injection schedule occasionally produces a poor incidence of EAMG. Read More

    CD59 polymorphisms are associated with gene expression and different sexual susceptibility to pemphigus foliaceus.
    Autoimmunity 2017 Sep 23;50(6):377-385. Epub 2017 May 23.
    a Laboratory of Human Molecular Genetics, Department of Genetics , Universidade Federal do Paraná , Curitiba , Brazil.
    Pemphigus foliaceus (PF) is an autoimmune disease, endemic in Brazilian rural areas, characterized by acantholysis and accompanied by complement activation, with generalized or localized distribution of painful epidermal blisters. CD59 is an essential complement regulator, inhibiting formation of the membrane attack complex, and mediating signal transduction and activation of T lymphocytes. CD59 has different transcripts by alternative splicing, of which only two are widely expressed, suggesting the presence of regulatory sites in their noncoding regions. Read More

    Genotype and haplotype analysis of ABCB1 at 1236, 2677 and 3435 among systemic sclerosis patients.
    Autoimmunity 2017 Aug 23;50(5):277-282. Epub 2017 May 23.
    b Department of Dermatology and Venereology, Chair of Dermatology and Venereology , Medical University of Lodz , Łódź, Poland.
    Systemic sclerosis (SSc) belongs to the group of systemic diseases of the connective tissue, which are characterized by a chronic autoimmune inflammatory process. P-glycoprotein, initially associated with the drug resistance in patients with cancer, becomes more and more often a subject of considerations in terms of its significance in the development of illnesses, including autoimmune diseases. The aim of the study was an attempt to answer the question whether there was a relationship between ABCB1 polymorphisms and morbidity of systemic sclerosis in a Polish population. Read More

    Adipose tissue infiltration in minor salivary glands of patients with Sjögren's syndrome: Lack of significant correlation with the disease. An image analysis of 174 cases().
    Autoimmunity 2017 Jun 23;50(4):199-201. Epub 2017 Apr 23.
    a Department of Pathology, Oral Pathology Unit , Medical School and Clinical Center, Pécs University , Pecs, Hungary.
    Fatty infiltration in minor salivary gland biopsies and its correlation to systemic autoimmune diseases are controversial in the literature. Presence and extent of fatty infiltration in minor salivary glands of 107 Sjögren's syndrome patients and 67 age-matched sicca controls were compared with statistical analyses. No significant difference was found regarding the presence or the extent of fatty infiltration between the two groups. Read More

    Decreased TLR4 expression on monocytes may cause regulatory T cells abnormality in patients with primary immune thrombocytopenia.
    Autoimmunity 2017 Aug 17;50(5):283-292. Epub 2017 Apr 17.
    a State Key Laboratory of Experimental Hematology , Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College , Tianjin , PR China.
    Primary immune thrombocytopenia (ITP) is an autoimmune disease with many immune dysfunctions including T helper type 1 cell (Th1) polarization and regulatory T cells (Tregs) deficiency. This study aimed to determine the effects of TLR4 on Treg differentiation and the cytokine production of peripheral blood mononuclear cells (PBMCs) from patients with ITP. We found that expression of TLR4 on monocytes was significantly decreased in patients with active ITP than that in healthy controls and it had positive correlation with platelet count. Read More

    Is autoimmunology a discipline of its own? A big data-based bibliometric and scientometric analyses.
    Autoimmunity 2017 Jun 23;50(4):269-274. Epub 2017 Mar 23.
    b Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center , Tel- Hashomer, Israel.
    Autoimmunology is a super-specialty of immunology specifically dealing with autoimmune disorders. To assess the extant literature concerning autoimmune disorders, bibliometric and scientometric analyses (namely, research topics/keywords co-occurrence, journal co-citation, citations, and scientific output trends - both crude and normalized, authors network, leading authors, countries, and organizations analysis) were carried out using open-source software, namely, VOSviewer and SciCurve. A corpus of 169,519 articles containing the keyword "autoimmunity" was utilized, selecting PubMed/MEDLINE as bibliographic thesaurus. Read More

    Annexin A1 as a target for managing murine pristane-induced systemic lupus erythematosus.
    Autoimmunity 2017 Jun 16;50(4):257-268. Epub 2017 Mar 16.
    a Laboratory of Experimental Immunology, Institute of Microbiology, Bulgarian Academy of Sciences , Sofia , Bulgaria.
    Systemic lupus erythematosus (SLE) is a polygenic pathological disorder which involves multiple organs. Self-specific B cells play a main role in the lupus pathogenesis by generating autoantibodies as well as by serving as important autoantigen-presenting cells. Autoreactive T lymphocytes, on the other hand, are responsible for B cell activation and proliferation, and cytokine production. Read More

    Complex interaction between HNRNPD mutations and risk polymorphisms is associated with discordant Crohn's disease in monozygotic twins.
    Autoimmunity 2017 Aug 16;50(5):275-276. Epub 2017 Mar 16.
    a Genetics and Genomics Lab, Department of Studies in Genetics and Genomics , University of Mysore , Mysuru , India.
    Crohn's disease (CD) is a chronic inflammatory bowel disease (IBD) affecting the lining of digestive tracts of the colon and ileum. To investigate the reasons behind the presence of CD phenotype in one of the monozygotic (MZ) twins, we utilized the whole exome sequence (WES) datasets of CD tissue biopsy and CD blood of affected twin and the exome dataset of blood from healthy twin. We report the presence of discordant and rare damaging mutation in HNRNPD and other risk polymorphisms such as, rs12103, rs2241880, rs3810936, rs7076156, rs1042058 and rs1292053. Read More

    Inflammation in Sjögren's syndrome: Cause or consequence?
    Autoimmunity 2017 May 14;50(3):141-150. Epub 2017 Feb 14.
    a Department of Biochemistry , Faculty of Medicine, University of Porto , Porto , Portugal and.
    Sjögren's syndrome (SS) is an autoimmune disease most commonly characterized by ocular and oral dryness. Despite the high prevalence of SS, generation and perpetuation of this disease is still unclear in many aspects. Inflammation, nonetheless, seems to play a central role in this pathology especially in the form of Th-1, Th-2 and Th-17 cytokines release within different aspects, concentrations and connections involved in the maintenance of the syndrome. Read More

    Diagnostic significance of serum concentrations of soluble Fas ligand (sFasL) in children with autoimmune thyroid disease.
    Autoimmunity 2017 May 21;50(3):192-198. Epub 2017 Feb 21.
    a Department of Pediatric Endocrinology and Rheumatology and.
    Introduction: The aim of the study was to assess serum levels of sFasL as a marker of thyroid dysfunction in children with autoimmune thyroid disease (AITD).

    Design: The group comprised 45 newly diagnosed children with Hashimoto's thyroiditis and Graves' disease versus euthyroid control group: 11 with hypothyroidism (10 girls and 1 boy, aged 12.2 ± 1. Read More

    Aberrant function of myeloid-derived suppressor cells (MDSCs) in experimental colitis and in inflammatory bowel disease (IBD) immune responses.
    Autoimmunity 2017 May 3;50(3):170-181. Epub 2017 Mar 3.
    d Division of Clinical , Experimental Surgery, & Translational Research, Biomedical Research Foundation of the Academy of Athens , Athens , Greece.
    Background And Aims: Myeloid-derived suppressor cells (MDSCs) encompass a novel population of suppressor cells and a potential candidate for cell-based therapies in inflammatory diseases. Herein, we investigated their immunomodulatory properties in experimental inflammatory colitis and T cell-mediated immune responses in inflammatory bowel disease (IBD) patients.

    Methods: MDSCs (defined as CD14(-)HLA(-)DR(-/low)CD33(+)CD15(+)) numbers were determined in peripheral blood (PB) from IBD patients. Read More

    Decreased serum DNase1-activity in patients with autoimmune liver diseases.
    Autoimmunity 2017 Mar 14;50(2):125-132. Epub 2017 Feb 14.
    a Department of Medicine and Research Laboratory of Internal Medicine , School of Medicine, University of Thessaly , Larissa , Greece.
    Deoxyribonuclease1 (DNase1) is involved in chromatin degradation of apoptotic cells. Its deficiency results in accumulation of self-DNA, which in turn may induce inflammation and autoimmunity. We assessed for the first time serum DNase1-activity in a large consecutive cohort of treatment-naïve patients with autoimmune liver diseases (ALD). Read More

    Modulation of the peripheral immune system after low-dose radon spa therapy: Detailed longitudinal immune monitoring of patients within the RAD-ON01 study.
    Autoimmunity 2017 Mar 21;50(2):133-140. Epub 2017 Feb 21.
    a Department of Radiation Oncology , Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg , Erlangen , Germany.
    The pain-relieving effects of low-dose radon therapies on patients suffering from chronic painful inflammatory diseases have been described for centuries. Even though it has been suggested that low doses of radiation may attenuate chronic inflammation, the underlying mechanisms remain elusive. Thus, the RAD-ON01 study was initiated to examine the effects of radon spa therapy and its low doses of alpha radiation on the human immune system. Read More

    Type-III interferons and rheumatoid arthritis: Correlation between interferon lambda 1 (interleukin 29) and antimutated citrullinated vimentin antibody levels.
    Autoimmunity 2017 Mar 14;50(2):82-85. Epub 2017 Feb 14.
    c Department of Immunology.
    Aim: To assess serum type III or lambda (λ) interferons (IFN) levels and its clinical and laboratory associations in rheumatoid arthritis (RA).

    Methods: A cross-sectional study including 43 patients with RA (86% females; age 45.3 ± 10. Read More

    Transcriptional and epigenetic regulation of follicular T-helper cells and their role in autoimmunity.
    Autoimmunity 2017 Mar 21;50(2):71-81. Epub 2017 Feb 21.
    a Department of Dermatology , Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics , Changsha , China and.
    T-follicular helper (Tfh) cells are a specialized subset of T cells that provide help to B cells and promote the formation of germinal centers (GCs). Tfh cells transmit important signals to B cells that drive class switch recombination, somatic hyper-mutation, the generation of high-affinity antibodies, immunological memory and their differentiation into plasma cells or memory B cells in the GCs. Tfh-cell differentiation is regulated by the coordinated functions of distinct cytokines, including interleukin (IL)-6, IL-21, IL-12, IL-23, IL-2, IL-7 and transforming growth factor-β (TGF-β), as well as transcription factors, including B-cell lymphoma 6 protein (Bcl-6), Signal transducers and activators of transcription (STAT)1, STAT3, STAT4, B-cell activating transcription factor (Batf), interferon regulatory factor 4 (IRF4), v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog (C-Maf), T-cell-specific transcription factor 1 (TCF-1) and Achaete-scute homolog 2 (Acl2), which have been shown to form a complex transcriptional network. Read More

    Spontaneous germinal centers and autoimmunity.
    Autoimmunity 2017 Feb;50(1):4-18
    a Department of Microbiology and Immunology, Penn State College of Medicine , USA.
    Germinal centers (GCs) are dynamic microenvironments that form in the secondary lymphoid organs and generate somatically mutated high-affinity antibodies necessary to establish an effective humoral immune response. Tight regulation of GC responses is critical for maintaining self-tolerance. GCs can arise in the absence of purposeful immunization or overt infection (called spontaneous GCs, Spt-GCs). Read More

    Pathogenic mechanisms of IgE-mediated inflammation in self-destructive autoimmune responses.
    Autoimmunity 2017 Feb;50(1):25-36
    a Department of Respiratory , Inflammation & Autoimmunity, MedImmune LLC , Gaithersburg , MD , USA.
    Autoantibodies of the IgG subclass are pathogenic in a number of autoimmune disorders such as systemic lupus erythomatosus. The presence of circulating IgE autoantibodies in autoimmune patients has also been known for almost 40 years. Despite their role in allergies, IgE autoantibodies are not associated with a higher rate of atopy in these patients. Read More

    B cell contribution of the CD4(+) T cell inflammatory phenotypes in systemic lupus erythematosus.
    Autoimmunity 2017 Feb;50(1):37-41
    a Department of Pathology, Immunology, and Laboratory Medicine , University of Florida , Gainesville , FL , USA.
    Systemic lupus erythematosus is an autoimmune disease in which the effector molecules responsible for tissue damage are antibodies directed against a large number of self-antigens, among which nucleic acids complexed with proteins play a prominent role. These pathogenic autoantibodies are produced by plasma cells differentiated from activated autoreactive B cells, a process that requires complex interactions between multiple components of the immune systems. A key step in the activation of autoreactive B cells is provided by CD4(+ )T cells through cytokines and cell-to-cell contact. Read More

    Clonally expanded cytotoxic CD4(+) T cells and the pathogenesis of IgG4-related disease.
    Autoimmunity 2017 Feb;50(1):19-24
    a Massachusetts General Hospital, Harvard Medical School , Boston , MA , USA.
    IgG4-related disease (IgG4-RD) is a systemic condition of unknown cause characterized by highly fibrotic lesions, with dense lymphoplasmacytic infiltrates containing a preponderance of IgG4-expressing plasma cells. CD4(+) T cells and B cells constitute the major inflammatory cell populations in IgG4-RD lesions. IgG4-RD patients with active, untreated disease show a marked expansion of plasmablasts in the circulation. Read More

    B cells in multiple sclerosis.
    Autoimmunity 2017 Feb;50(1):57-60
    a MPI Neurobiology , Martinsried , Germany.
    B lymphocytes have essential roles in the autoimmune pathogenesis of multiple sclerosis (MS). They regulate the autoimmune response and participate in the development of the CNS lesions. This review discusses nature and functions of B cells in MS, and retraces the recruitment of brain-autoimmune B cells from the B cell repertoire. Read More

    Opposing roles of B lymphocyte subsets in atherosclerosis.
    Autoimmunity 2017 Feb;50(1):52-56
    b Department of Medicine , Southern Clinical School, Monash University , Victoria , Australia , and.
    Atherosclerosis is initiated by cholesterol entry into arteries that triggers chronic immune-inflammatory lesions in the vessels. Early lesions are clinically insignificant but advanced complex lesions and vulnerable rupture prone lesions impact on quality of life and can be life threatening. Rupture of vulnerable atherosclerotic lesions initiates thrombotic occlusion of vital arteries precipitating heart attacks and strokes that remain major killers globally despite therapeutic use of statins to lower blood cholesterol levels. Read More

    Alterations in B cell development, CDR-H3 repertoire and dsDNA-binding antibody production among C57BL/6 ΔD-iD mice congenic for the lupus susceptibility loci sle1, sle2 or sle3.
    Autoimmunity 2017 Feb;50(1):42-51
    a Department of Medicine , University of Alabama at Birmingham , Birmingham , AL , USA.
    Systemic lupus erythematosus (SLE) is an autoimmune disease that reflects a failure to block the production of self-reactive antibodies, especially those that bind double-stranded DNA (dsDNA). Backcrossing the lupus-prone NZM2410 genome onto C57BL/6 led to the identification of three genomic intervals, termed sle1, sle2 and sle3, which are associated with lupus susceptibility. We previously generated a C57BL/6 strain congenic for an immunoglobulin DH locus (ΔD-iD) that enriches for arginine at dsDNA-binding positions. Read More

    p19-targeted ABD-derived protein variants inhibit IL-23 binding and exert suppressive control over IL-23-stimulated expansion of primary human IL-17+ T-cells.
    Autoimmunity 2017 Mar 19;50(2):102-113. Epub 2017 Jan 19.
    a Laboratory of Ligand Engineering , Institute of Biotechnology, Czech Academy of Sciences, v. v. i, BIOCEV Research Center , Vestec , Czech Republic.
    Interleukin-23 (IL-23), a heterodimeric cytokine of covalently bound p19 and p40 proteins, has recently been closely associated with development of several chronic autoimmune diseases such as psoriasis, psoriatic arthritis or inflammatory bowel disease. Released by activated dendritic cells, IL-23 interacts with IL-23 receptor (IL-23R) on Th17 cells, thus promoting intracellular signaling, a pivotal step in Th17-driven pro-inflammatory axis. Here, we aimed to block the binding of IL-23 cytokine to its cell-surface receptor by novel inhibitory protein binders targeted to the p19 subunit of human IL-23. Read More

    Inflammatory arthritis and systemic bone loss are attenuated by gastrointestinal helminth parasites.
    Autoimmunity 2017 May 13;50(3):151-157. Epub 2017 Jan 13.
    b Ecole Polytechnique Fédérale de Lausanne (EPFL), Global Health Institute , Lausanne , Switzerland , and.
    Infections with different helminth species have been observed to ameliorate a variety of chronic inflammatory diseases. Herein, we show that the natural murine helminth species, Heligmosomoides polygyrus bakeri (Hp) is capable of attenuating disease severity in two different inflammatory arthritis models. Furthermore, we show that excretory-secretory (ES) products from Hp directly suppress osteoclast differentiation in vitro. Read More

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