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    2408 results match your criteria Autoimmunity [Journal]

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    Race/ethnicity is an independent risk factor for autoimmune hepatitis among the San Francisco underserved.
    Autoimmunity 2018 Jun 11:1-7. Epub 2018 Jun 11.
    d Department of Medicine, Division of Gastroenterology , University of California San Francisco , San Francisco , CA , USA.
    Although autoimmune hepatitis (AIH) is more common in women and affects people of all races/ethnicities, there is currently limited information regarding the relationship between race/ethnicity and AIH, especially in the context of underserved populations. We aim to evaluate the relationship between race/ethnicity and AIH and better characterize its clinical features among different racial groups. We conducted a 15-year retrospective analysis, from January 2002 to June 2017, of patients seen at Zuckerberg San Francisco General Hospital (ZSFG). Read More

    Clinical significance of combined detection of interleukin-6 and tumour markers in lung cancer.
    Autoimmunity 2018 Jun 5:1-8. Epub 2018 Jun 5.
    a Department of Thoracic and Cardiovascular Surgery , Zhongnan Hospital of Wuhan University , Wuhan , Hubei , China.
    Tumour markers play an important role in the early diagnosis and guidance of prognosis of lung cancer. This study focused on the significance of combined monitoring of interleukin (IL)-6 and tumour markers in improving the specificity and sensitivity of lung cancer diagnosis and disease. The expression of IL-6, carcinoembryonic antigen (CEA), neuron-specific enolase (NSE) and cytokeratin 19 fragment antigen 21-1 (CYFRA21-1) in serum of patients with non-small cell lung cancer (NSCLC) (n = 138) was significantly higher compared to patients with benign pulmonary lesions (BPL) (n = 60) and was associated with the clinicopathological features of NSCLC patients. Read More

    Features of peripheral CD8CD57 lymphocytes in patients with autoimmune hemolytic anemia.
    Autoimmunity 2018 May 30:1-9. Epub 2018 May 30.
    a Department of Biomedical Sciences and Human Oncology , University of Bari "Aldo Moro" , Bari , Italy.
    Autoimmune hemolytic anemia (AIHA) is an acquired condition characterized by the presence of autoantibodies recognizing erythrocyte-related antigens. Several components of the immune system are involved in disease pathogenesis. Among them, as for other autoimmune disorders, a role for specific CD8CD57 regulatory cells subset could be hypothesized. Read More

    Glycosylation of random IgG distinguishes seropositive and seronegative rheumatoid arthritis.
    Autoimmunity 2018 May 7;51(3):111-117. Epub 2018 May 7.
    a Department of Internal Medicine 3 - Rheumatology and Immunology , Friedrich-Alexander Universität Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen , Erlangen , Germany.
    The N-glycosylation of human immunoglobulins, especially IgGs, plays a critical role in determining affinity of IgGs towards their effector (pro- and anti-inflammatory) receptors. However, it is still not clear whether altered glycosylation is involved in only antibody-dependent disorders like seropositive rheumatoid arthritis (RA) or also in pathologies with similar clinical manifestations, but no specific autoantibodies like seronegative RA. The clarification of that uncertainty was the aim of the current study. Read More

    New genetically engineered DFS70 knock-out HEp-2 cells enable rapid and specific recognition of anti-DFS70 antibodies.
    Autoimmunity 2018 May 6:1-5. Epub 2018 May 6.
    b Azienda Sanitaria Universitaria Integrata , Udine , Italy.
    Background: The correct identification of anti-dense fine speckled-70 (DFS70) antibodies represents an important issue in the detection of anti-nuclear antibodies (ANAs) as performed by the indirect immunofluorescence (IIF) test on HEp-2 substrates. In this study, we have evaluated a new method for anti-DFS70 antibody detection employing HEp-2 cells knocked-out for the DFS70 antigen.

    Methods: We studied 148 sera with a DFS70-like pattern (91 positive and 57 negative when tested for anti-DFS70 antibodies by a specific chemoluminescence [CLIA] method); 116 sera with infectious disease; 100 healthy donors (HDs), 139 samples from patients with a defined diagnosis of autoimmune rheumatic disease (ARD), and 242 consecutive unselected samples screened for ANA during the routine work-up. Read More

    SAMHD1: Recurring roles in cell cycle, viral restriction, cancer, and innate immunity.
    Autoimmunity 2018 May 27;51(3):96-110. Epub 2018 Mar 27.
    a Department of Biochemistry , Center for Structural Biology, Wake Forest School of Medicine , Winston Salem , NC , USA.
    Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1) is a deoxynucleotide triphosphate (dNTP) hydrolase that plays an important role in the homeostatic balance of cellular dNTPs. Its emerging role as an effector of innate immunity is affirmed by mutations in the SAMHD1 gene that cause the severe autoimmune disease, Aicardi-Goutieres syndrome (AGS) and that are linked to cancer. Additionally, SAMHD1 functions as a restriction factor for retroviruses, such as HIV. Read More

    Altered expression of transcription factors IRF4 and IRF8 in peripheral blood B cells is associated with clinical severity and circulating plasma cells frequency in patients with myasthenia gravis.
    Autoimmunity 2018 May 23;51(3):126-134. Epub 2018 Mar 23.
    a Department of Neurology , Affiliated Hospital of Xuzhou Medical University , Xuzhou , Jiangsu , China.
    Previous studies have shown that interferon regulatory factor-4 (IRF4) and IRF8 play critical but distinct roles in the differentiation of B cells into plasma cells (PCs). In the present study, we aimed to measure the expression levels of IRF4 and IRF8 in B cells from patients with myasthenia gravis (MG) and to investigate whether the expression of IRF4 and IRF8 associates with pathogenesis of MG. A total of 35 anti-acetylcholine receptor (AChR) antibody (Ab)-positive patients with MG [20 generalized MG (GMG) and 15 ocular MG (OMG) and 25 healthy donors were recruited in this study. Read More

    Methylation levels of the TNFA gene are different between Graves' and Hashimoto's diseases and influenced by the TNFA polymorphism.
    Autoimmunity 2018 May 11;51(3):118-125. Epub 2018 Mar 11.
    a Department of Biomedical Informatics, Division of Health Sciences , Osaka University Graduate School of Medicine , Suita , Osaka , Japan.
    Graves' disease (GD) and Hashimoto's disease (HD) are different pathological types of autoimmune thyroid diseases (AITDs). However, the epigenetic differences between these diseases have not been elucidated. DNA methylation is one of the primary epigenetic modifications that reflect environmental influences on gene expression. Read More

    Signalling pathways identified in salivary glands from primary Sjögren's syndrome patients reveal enhanced adipose tissue development.
    Autoimmunity 2018 May 5;51(3):135-146. Epub 2018 Mar 5.
    b Department of Clinical Medicine, Gade Laboratory for Pathology , University of Bergen , Bergen , Norway.
    A characteristic feature of primary Sjögren's syndrome (pSS) is the destruction of salivary and lacrimal glands mediated by mononuclear cell infiltration. Adipocytes can also occupy a large portion of the salivary gland (SG) tissue area, although little is known about their significance in pSS. We have previously investigated adipose tissue infiltration in SG biopsies from pSS patients and non-SS sicca controls. Read More

    Protective effects of quercetin treatment in a pristane-induced mouse model of lupus nephritis.
    Autoimmunity 2018 Mar 26;51(2):69-80. Epub 2018 Feb 26.
    a Graduate Program in Medical Sciences , Universidade Federal do Rio Grande do Sul , Porto Alegre , Brazil.
    Introduction: Lupus nephritis (LN) is one of the most severe complications of systemic lupus erythematosus. As murine models of LN are valuable tools to better understand its pathophysiology and to search for new effective treatments, we investigated the effects of the bioflavonoid quercetin on pristane-induced LN mice through histomorphological analyses.

    Methods: Immunofluorescence and biochemical assays were used to evaluate the expression of markers of inflammation (interleukin-6, IL-6; tumour necrosis factor-α, TNF-α), oxidative stress (catalase, CAT; superoxide dismutase 1, SOD1; thiobarbituric acid reactive substances, TBARS), apoptosis (Bax), and fibrosis (transforming growth factor-β1, TGF-β1). Read More

    miR-148b-3p affects the pathogenesis of adjuvant-induced arthritis rats through the direct target DNMT1.
    Autoimmunity 2018 Mar 23;51(2):43-52. Epub 2018 Feb 23.
    a Department of Pharmacy, School of Food and Drug , Anhui Science and Technology University , Fengyang , China.
    Our previous study showed that up-regulated DNA methyltransferase-1 (DNMT1) played an important role in the hypermethylation modification of SFRP4 in adjuvant-induced arthritis (AIA) rats. This work focused on the role of disordered miR-148b-3p in RA pathology and its corresponding regulatory targets. The expression of miR-148b-3p and DNMT1, and the effect of miR-148b-3p on the DNMT1 expression were determined by real-time qPCR, western blotting and double luciferase reporter genes. Read More

    Alterations in nucleotide-binding oligomerization domain-2 expression, pathway activation, and cytokine production in Yao syndrome.
    Autoimmunity 2018 Mar 22;51(2):53-61. Epub 2018 Feb 22.
    b Department of Rheumatic and Immunologic Disease , Orthopaedic and Rheumatologic Institute, Cleveland Clinic , Cleveland , OH , USA.
    Yao syndrome (YAOS) is a systemic autoinflammatory disease (SAID), formerly termed nucleotide-binding oligomerization domain-2 (NOD2)-associated autoinflammatory disease. Due to the recent identification of YAOS, the molecular mechanisms underlying its disease pathogenesis are unclear. With specific NOD2 variants as characteristic genotypic features of YAOS, our study examined NOD2 expression, transcript splicing, signaling pathway activation, and cytokine profiles in peripheral blood mononuclear cells (PBMCs) from 10 YAOS patients and six healthy individuals. Read More

    Clinical contribution of myositis-related antibodies detected by immunoblot to idiopathic inflammatory myositis: A one-year retrospective study.
    Autoimmunity 2018 Mar 20;51(2):89-95. Epub 2018 Feb 20.
    b Centre de Recherche en Transplantation et Immunologie (CRTI), UMR 1064, Inserm , Université de Nantes , Nantes , France.
    In this study, we aimed at evaluating the contribution of an extended myositis-related antibodies (Abs) determination by immunoblot to the diagnosis, classification, and prognosis of idiopathic inflammatory myositis (IIM). Medical records of all the patients (n = 237) with myositis-related Ab requests addressed to our department over a one-year period were retrospectively analyzed. Patients were classified as IIM, auto-immune disease (AID) other than IIM, and other diagnosis, and examined for their Ab profiles as determined by immunoblot. Read More

    Functional TSH receptor antibodies in children with autoimmune thyroid diseases.
    Autoimmunity 2018 Mar 26;51(2):62-68. Epub 2018 Jan 26.
    j Molecular Thyroid Research Laboratory, Department of Medicine I , Johannes Gutenberg University (JGU) Medical Center , Mainz , Germany.
    Introduction: The diagnostic value of the level of TSH receptor antibodies (TSHR-Ab) in the population of children with autoimmune thyroid diseases (AITDs) is still unknown. The aim of this cross-sectional study was to investigate the prevalence of TSHR-Ab in a paediatric cohort with AITD and healthy controls.

    Materials And Methods: A total of 240 serum samples were obtained from 205 patients with AITD, type 1 diabetes (T1D), juvenile arthritis (JA), and healthy controls (C). Read More

    Bone marrow mesenchymal stem cells suppress IL-9 in adjuvant-induced arthritis.
    Autoimmunity 2018 Feb 23;51(1):25-34. Epub 2018 Jan 23.
    a Zoology Department, Faculty of Women for Arts, Science and Education , Ain Shams University , Cairo , Egypt.
    Interleukin-9 (IL-9) has been shown to be upregulated in rheumatoid arthritis (RA). The exact role of IL-9 has not yet been effectively studied. Mesenchymal stem cells (MSCs) have shown a promising immunomodulatory role towards repairing cartilage and restoring joint function. Read More

    Celiac antibodies in children with type 1 diabetes - A diagnostic validation study.
    Autoimmunity 2018 Mar 19;51(2):81-88. Epub 2018 Jan 19.
    a Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age , Medical University of Warsaw , Warsaw , Poland.
    Introduction: Autoimmune diseases, such as celiac disease (CD) and diabetes mellitus type 1, tend to co-occur within the same patient. The prevalence of CD in diabetic children is higher than in the general population, and is estimated to be 0.6-16. Read More

    Gain of function mutant of complement factor B K323E mimics pathogenic C3NeF autoantibodies in convertase assays.
    Autoimmunity 2018 Feb 8;51(1):18-24. Epub 2018 Jan 8.
    a Department of Medical Biotechnology , Intercollegiate Faculty of Biotechnology UG-GUMED , Gdańsk , Poland.
    Complement convertases are enzymatic complexes, which play a critical role in propagation and amplification of the complement cascade. Under physiological conditions, convertases decay shortly after being formed in either spontaneous or inhibitor-driven process. Prolongation of their half-life by C3NeF autoantibodies that prevent convertase dissociation results in pathogenic condition often manifested by renal diseases. Read More

    Deficiency of autoimmune regulator impairs the immune tolerance effect of bone marrow-derived dendritic cells in mice.
    Autoimmunity 2018 Feb 3;51(1):10-17. Epub 2018 Jan 3.
    a Department of Immunology, College of Basic Medical Sciences , Jilin University , Changchun , Jilin , China.
    As a transcription factor, autoimmune regulator (Aire) participates in thymic negative selection and maintains immune tolerance mainly by regulating the ectopic expression of tissue-restricted antigens (TRAs) in medullary thymic epithelial cells (mTECs). Aire is also expressed in dendritic cells (DCs). DCs are professional antigen-presenting cells (APCs) that affect the differentiation of T cells toward distinct subpopulations and participate in the immune response and tolerance, thereby playing an important role in maintaining homeostasis. Read More

    IL-17 and related cytokines involved in systemic sclerosis: Perspectives.
    Autoimmunity 2018 Feb 19;51(1):1-9. Epub 2017 Dec 19.
    b Laboratório de Imunomodulação e Novas Abordagens Terapêuticas Suely Galdino , Universidade Federal de Pernambuco , Recife , Brazil.
    Systemic sclerosis (SSc) is a multisystemic, complex, and rare disease of connective tissue, with high morbidity and mortality, and without specific treatment. The disease is characterized by three main principles: vascular disease, autoantibody production and inflammation, and fibrosis. Since it is well defined that SSc is characterized by elevated production of TGF-β, IL-6, and IL-1, all of them cytokines related to Th17 differentiation, the hypothesis is that this disease may be strongly related to a polarization of the immune response towards the Th17 pathway. Read More

    Polymorphisms and expression of genes encoding Argonautes 1 and 2 in autoimmune thyroid diseases.
    Autoimmunity 2018 Feb 19;51(1):35-42. Epub 2017 Dec 19.
    a Department of Biomedical Informatics, Division of Health Sciences , Osaka University Graduate School of Medicine , Suita , Osaka , Japan.
    The microRNA (miRNA) biogenesis pathway is regulated by specific proteins and enzymes, including Dicer, Drosha, DGCR8, Exportin 5 and the Argonaute (AGO) family. In this study, we investigated the AGO family, which is the primary component of RISC (RNA-induced silencing complex) and directly binds to microRNA. We examined the association of polymorphisms in AGO family genes with AGO expression and with the development and prognosis of autoimmune thyroid diseases. Read More

    The relationship between cell apoptosis dysfunction and FEN1 E160D mutation in lupus nephritis patients.
    Autoimmunity 2017 Dec;50(8):476-480
    a Department of Nephropathy , Lanzhou University Second Hospital , Lanzhou , PR China.
    Objective: This study aims to evaluate the role of FEN1 E160D mutation in lupus nephritis (LN) patients with cell apoptosis dysfunction.

    Methods: (1) Cell apoptosis was detected from 50 paraffin samples obtained from renal biopsies of patients with Class IV LN by TUNEL method and the relationship of the systemic lupus erythematosus disease activity index 2000 (SLEDAI 2000) and renal tissue cell apoptotic index (AI) was discussed. (2) FEN1 gene 61563142-61563342 containing E160D were analysed by extracting genomic DNA from peripheral blood collected from the above 50 LN patients and 25 patients with nephrectomy caused by renal trauma. Read More

    High expression of interleukine-1 receptor antagonist in rheumatoid arthritis: Association with IL1RN*2/2 genotype.
    Autoimmunity 2017 Dec 11;50(8):468-475. Epub 2017 Dec 11.
    a Instituto de Investigación en Ciencias Biomédicas, CUCS , Universidad de Guadalajara , Guadalajara , México.
    Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation and pro-inflammatory cytokines production. IL-1Ra is an anti-inflammatory cytokine codified by IL1RN gene that blocks IL-1 signalling. A VNTR polymorphism of 86 bp in IL1RN gene has been associated with RA risk and regulation of IL-1Ra expression. Read More

    Articular and subcutaneous adipose tissues of rheumatoid arthritis patients represent equal sources of immunoregulatory mesenchymal stem cells.
    Autoimmunity 2017 Dec 6;50(8):441-450. Epub 2017 Dec 6.
    a Department of Pathophysiology and Immunology , National Institute of Geriatrics, Rheumatology and Rehabilitation , Warsaw , Poland.
    Adipose-derived mesenchymal stem cells (ASCs) have immunoregulatory properties, but their activity is dependent on signals provided by the local microenvironment. It is likely that highly inflammatory milieu of rheumatoid joint affects ASCs activity. To test this hypothesis, the function of rheumatoid ASCs derived from articular adipose tissue (AT-ASCs) and ASCs derived from subcutaneous adipose tissue (Sc-ASCs) has been analysed. Read More

    T-cell receptor-mediated characteristic signaling pathway of peripheral blood T cells in dermatomyositis and polymyositis.
    Autoimmunity 2017 Dec 25;50(8):481-490. Epub 2017 Nov 25.
    a Department of Medicine (Neurology and Rheumatology) , Shinshu University School of Medicine , Matsumoto , Japan.
    The characteristics of T cell expression in peripheral blood have been previously described in dermatomyositis (DM) and polymyositis (PM); however, their intracellular signaling profiles remain unknown. The purpose of this study was to investigate the T-cell receptor (TCR)-mediated intracellular signaling in peripheral blood T cells in DM and PM. Peripheral blood T cells from 86 patients with DM (n = 57) and PM (n = 29) were used for experimental investigations. Read More

    Higher frequencies of circulating ICOS, IL-21 T follicular helper cells and plasma cells in patients with new-onset membranous nephropathy.
    Autoimmunity 2017 Dec 13;50(8):458-467. Epub 2017 Oct 13.
    a Genetic Diagnosis Center , The First Hospital of Jilin University , Changchun , China.
    Background: T follicular helper (TFH) cells and B cells are known to regulate humoral immune responses. This study is aimed at examining the putative contribution of different subsets of circulating of TFH cells and B cells to membranous nephropathy (MN).

    Methods: A total of 45 MN patients and 19 healthy controls (HCs) were examined for the number of TFH cells and B cells by flow cytometry. Read More

    PTPN22 1858C > T polymorphism and susceptibility to systemic lupus erythematosus: a meta-analysis update.
    Autoimmunity 2017 Nov 8;50(7):428-434. Epub 2017 Oct 8.
    a Laboratory of Immunopathology Keizo Asami (LIKA) , Federal University of Pernambuco , Recife , Brazil.
    Studies performed in the past years showed PTNP22 1858 C > T (rs2476601) polymorphism as associated with systemic lupus erythematosus susceptibility, although conflicting findings are still found. In this context, a powerful statistical study, such as meta-analysis, is necessary to establish a consensus. The aim of this study was to evaluate association studies between the PTPN22 1858 C > T polymorphism and SLE by a meta-analysis update, including three recently published studies in the last three years. Read More

    Fatty infiltration of the minor salivary glands is a selective feature of aging but not Sjögren's syndrome.
    Autoimmunity 2017 Dec 8;50(8):451-457. Epub 2017 Oct 8.
    a Arthritis and Clinical Immunology Program , Oklahoma Medical Research Foundation (OMRF) , Oklahoma City , OK , USA.
    Objective: Determine the presence and assess the extent of fatty infiltration of the minor salivary glands (SG) of primary SS patients (pSS) as compared to those with non-SS sicca (nSS).

    Methods: Minor SG biopsy samples from 134 subjects with pSS (n = 72) or nSS (n = 62) were imaged. Total area and fatty replacement area for each glandular cross-section (n = 4-6 cross-sections per subject) were measured using Image J (National Institutes of Health, Bethesda, MD). Read More

    Expression of activation-induced cytidine deaminase splicing variants in patients with ankylosing spondylitis.
    Autoimmunity 2017 Dec 29;50(8):435-440. Epub 2017 Sep 29.
    a Division of Rheumatology, Department of Medicine , Daejeon Rheumatoid and Degenerative Arthritis Center, Chungnam National University Hospital , Daejeon , Republic of Korea.
    To investigate the expression patterns of activation-induced cytidine deaminase (AID) variants in peripheral blood mononuclear cells (PBMCs) of patients with ankylosing spondylitis (AS) and examine their clinical implications, we isolated PBMCs from healthy controls (HC, n = 33) and patients with AS (n = 62), and measured mRNA expression of AID variants and translesion synthesis (TLS) polymerases using quantitative real-time polymerase chain reaction. The proportion of patients with AS in whom AID splicing variant (sv) 2 was expressed was significantly higher than that of HC (p = .031). Read More

    Interaction analysis between BLK rs13277113 polymorphism and BANK1 rs3733197 polymorphism, MMEL1/TNFRSF14 rs3890745 polymorphism in determining susceptibility to rheumatoid arthritis.
    Autoimmunity 2017 Nov 19;50(7):403-408. Epub 2017 Sep 19.
    a Department of Rheumatology , Ningbo First Hospital, Ningbo Hospital of Zhejiang University , Ningbo , Zhejiang , PR China.
    Two pairwise genetic interactions (B cell lymphocyte kinase (BLK) rs13277113,B cell scaffold protein with ankyrin repeats 1 (BANK1) rs3733197and BLK rs13277113 membrane metalloendopeptidase like 1 (MMEL1)/ tumor necrosis factor receptor superfamily member 14 (TNFRSF14) rs3890745) have been demonstrated in determining susceptibility to rheumatoid arthritis (RA) without replication, thus this study was performed to examine whether abovementioned genetic polymorphisms were associated with RA and further tests were performed to see whether aforementioned genetic interactions existed in RA among Chinese population. A total of 328 patients with RA and 449 healthy control subjects were included in the current study. The polymorphisms were genotyped using the ligase detection reaction-polymerase chain reaction (LDR-PCR) technology. Read More

    Effects of immunomodulators on the response induced by vaccines against autoimmune diseases.
    Autoimmunity 2017 Nov 14;50(7):393-402. Epub 2017 Sep 14.
    a Qantu Therapeutics, Inc , Lewisville , TX , USA.
    A promising treatment for T-cell-mediated autoimmune diseases is the induction of immune tolerance by modulating the immune response against self-antigens, an objective that may be achieved by vaccination. There are two main types of vaccines currently under development. The tolerogenic vaccines, composed of proteins formed by a cytokine fused to a self-antigen, which usually induce tolerance by eliminating the T-cells that are immune reactive against the self-antigen. Read More

    Mannose-binding lectin deficiency and miscarriages in rheumatoid arthritis.
    Autoimmunity 2017 Nov 12;50(7):409-413. Epub 2017 Sep 12.
    a Laboratory of Immunopathology , Clinical Hospital, Federal University of Paraná , Curitiba , Brazil.
    Objective: To investigate the association between mannose-binding lectin (MBL) serum level and MBL2 polymorphisms, and the frequency of spontaneous miscarriages in rheumatoid arthritis (RA) patients.

    Methods: One hundred seventy seven women (mean age 50 years) with RA from Southern Brazil were studied and 4.5% had a history of abortion (8/177). Read More

    Decreased bone mineral density in experimental myasthenia gravis in C57BL/6 mice.
    Autoimmunity 2017 Sep 29;50(6):346-353. Epub 2017 Aug 29.
    a Department of Biochemistry and Molecular Biology , Baylor College of Medicine , Houston , TX , USA.
    Experimental autoimmune myasthenia gravis (EAMG), an animal model of myasthenia gravis (MG), can be induced in C57BL/6 (B6, H-2 ) mice by 2-3 injections with Torpedo californica AChR (tAChR) in complete Freund's adjuvant. Some EAMG mice exhibit weight loss with muscle weakness. The loss in body weight, which is closely associated with bone structure, is particularly evident in EAMG mice with severe muscle weakness. Read More

    KLRG1 expression identifies short-lived Foxp3 T effector cells with functional plasticity in islets of NOD mice.
    Autoimmunity 2017 Sep 29;50(6):354-362. Epub 2017 Aug 29.
    a Department of Microbiology and Immunology , McGill University , Montréal , Québec , Canada.
    A progressive waning in Foxp3 regulatory T (T) cell function provokes autoimmunity in the non-obese diabetic (NOD) mouse model of type 1 diabetes (T1D), a cellular defect rescued by prophylactic IL-2 therapy. We showed that most islet-infiltrating T cells express inducible T-cell co-stimulator (ICOS) in pre-diabetic NOD mice, and that ICOS T cells display enhanced fitness and suppressive function in situ. Moreover, T1D progression is associated with decreased expansion and suppressive activity of ICOSFoxp3 T cells, in islets, an observation consistent with the exacerbated T1D seen in NOD. Read More

    Disease-related autoantibody profile in patients with systemic sclerosis.
    Autoimmunity 2017 Nov 27;50(7):414-421. Epub 2017 Jul 27.
    a Department of Rheumatology and Clinical Immunology , Faculty of Medicine, School of Health Sciences, University of Thessaly , Larissa , Greece.
    Background: Autoantibodies (autoAbs) help in diagnosis and predicting clinical phenotypes in systemic sclerosis (SSc).

    Aim Of The Study: To determine the clinical utility of 13 SSc-related autoAbs in SSc patients.

    Material And Methods: A total of 131 consecutive patients with SSc (111 female, mean age 58. Read More

    Nitration of H2B histone elicits an immune response in experimental animals.
    Autoimmunity 2017 Jun 24;50(4):232-240. Epub 2017 Jul 24.
    a Department of Biosciences , Jamia Millia Islamia , New Delhi , India.
    Histone H2B is an autoantigen that appears in circulation due to altered apoptosis/or insufficient clearance and is likely to be involved in the induction and progression of autoimmune diseases since modified-H2B is immunogenic. Our studies demonstrate that tyrosines of H2B histone spontaneously converts to free and nitrotyrosine bound protein in vivo. Commercially available H2B histone was modified with peroxynitrite in vitro. Read More

    Immunization of BALB/c mice with pigeon IgY induces the production of anti-IgG autoantibodies.
    Autoimmunity 2017 Sep 12;50(6):336-345. Epub 2017 Jul 12.
    b Laboratorio de Autoinmunidad , Unidad de Investigación INER , México City , México.
    The breakdown of immunological tolerance due to the activation of autoreactive B and T cells triggers physiopathological processes. An example of such conditions is the production of IgG autoantibodies specific for the Fc portion of IgG (anti-Fcγ IgG). Previous reports have shown that patients with pigeon-related hypersensitivity pneumonitis exhibit an increase in the serum levels of anti-Fcγ IgG. Read More

    Management of hydrocephalus associated with autoimmune diseases: a series of 19 cases.
    Autoimmunity 2017 Nov 7;50(7):422-427. Epub 2017 Jul 7.
    a The Department of Neurosurgery , Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , P.R. China.
    Objectives: To analyze the diagnosis and treatment of hydrocephalus associated with autoimmune diseases and to explore the possible mechanism of hydrocephalus in these patients.

    Methods: A retrospective case series study was conducted at Peking Union Medical College Hospital, Beijing, China. Files were retrieved from the hospital archives by screening records from Jan 1990 to Jan 2016. Read More

    Contribution of both B-cell intrinsic alterations as well as non-hematopoietic-derived factors in the enhanced immune response of the NOD mouse.
    Autoimmunity 2017 Sep 7;50(6):363-369. Epub 2017 Jul 7.
    a Department of Clinical Microbiology, Division of Immunology , Umeå University , Umeå , Sweden.
    The underlying cellular and molecular mechanism for the development of Type 1 diabetes is still to be fully revealed. We have previously demonstrated that the NOD mouse, a model for Type 1 diabetes, display a prolonged and enhanced immune response to both self and non-self-antigens. The molecular explanation for this defect however, has not been determined. Read More

    Impaired salivary gland activity in patients with autoimmune polyendocrine syndrome type I.
    Autoimmunity 2017 Jun 7;50(4):211-222. Epub 2017 Jul 7.
    a Department of Clinical Science , University of Bergen , Bergen , Norway.
    Autoimmune polyendocrine syndrome type I (APS-I) is a severe disease caused by mutations in the autoimmune regulator (AIRE) gene. We hypothesized that salivary gland dysfunction could be a possible unexplored component of these patients and here aimed to investigate salivary and lachrymal symptoms in the Norwegian cohort of APS-I patients (N = 41) and the aetiology behind it. Sicca symptoms and possible corresponding underlying factors were assessed by subjective reports combined with objective measures of saliva and tear flow, serological testing, immune fluorescence microscopy, ultrasonography and searching for putative autoantibodies in the salivary glands. Read More

    Caerulomycin A suppresses the differentiation of naïve T cells and alleviates the symptoms of experimental autoimmune encephalomyelitis.
    Autoimmunity 2017 Aug 7;50(5):317-328. Epub 2017 Jul 7.
    a Immunology Laboratory , CSIR-Institute of Microbial Technology , Chandigarh , India.
    Multiple sclerosis (MS) is a highly detrimental autoimmune disease of the central nervous system. There is no cure for it but the treatment typically focuses on subsiding severity and recurrence of the disease. Experimental autoimmune encephalomyelitis (EAE) is an animal model of MS. Read More

    Kinase inhibitors of the IGF-1R as a potential therapeutic agent for rheumatoid arthritis.
    Autoimmunity 2017 Aug 6;50(5):329-335. Epub 2017 Jul 6.
    b Department of Internal Medicine and Rheumatology, School of Medicine , Juntendo University , Tokyo , Japan.
    We have previously shown that the inhibition of connective tissue growth factor (CTGF) is a potential therapeutic strategy against rheumatoid arthritis (RA). CTGF consists of four distinct modules, including the insulin-like growth factor binding protein (IGFBP). In serum, insulin-like growth factors (IGFs) bind IGFBPs, interact with the IGF-1 receptor (IGF-1 R), and regulate anabolic effects and bone metabolism. Read More

    Identification of potential biomarkers for systemic lupus erythematosus diagnosis using two-dimensional differential gel electrophoresis (2D-DIGE) and mass spectrometry.
    Autoimmunity 2017 Jun 4;50(4):247-256. Epub 2017 Jul 4.
    a Department of Clinical and Toxicological Analysis, Faculty of Pharmacy , Universidade Federal de Minas Gerais , Belo Horizonte , Minas Gerais , Brazil.
    Systemic lupus erythematosus (SLE) is an autoimmune disease of the connective tissue with a large spectrum of clinical manifestations. Immune deregulation leads to autoantibody and immune complexes overproduction, complement activation, and persistent tissue inflammation. Considering that the current diagnosis depends on the interpretation of the complex criteria established by the American College of Rheumatology and that the disease course is characterized by unpredictable activations and remissions, each patient develops different manifestations, and therefore, the discovery of specific biomarkers is urgently required. Read More

    Association of the polymorphisms in the gene encoding thyroglobulin with the development and prognosis of autoimmune thyroid disease.
    Autoimmunity 2017 Sep 4;50(6):386-392. Epub 2017 Jul 4.
    a Department of Biomedical Informatics, Division of Health Sciences , Osaka University Graduate School of Medicine , Osaka , Japan.
    Graves' disease (GD) and Hashimoto's disease (HD) are autoimmune thyroid diseases (AITDs), and the prognosis of AITDs is different for each patient. We examined the association of polymorphisms in the Thyroglobulin (TG) gene with the pathogenesis of AITD. We genotyped TG rs180195G/A, rs853326G/A, rs2076740C/T, rs2703013G/T, rs2958692C/T and rs733735A/G polymorphisms in 137 HD patients, 131 GD patients and 89 healthy controls and also examined the levels of TG mRNA expression and serum TG. Read More

    Modification of anti-tumor immunity by tolerogenic dendritic cells.
    Autoimmunity 2017 Sep 4;50(6):370-376. Epub 2017 Jul 4.
    b Department of Biosciences and Nutrition , Karolinska Institutet , Novum, Huddinge , Sweden.
    Immunosuppressive functions of glucocorticoids (GC) can be mediated via various mechanisms, including the modulation of dendritic cells (DC). Our study investigates the effects of tolerogenic GC-treated DCs on NK and T cell anti-tumor responses in OT-1/Rag mice, expressing a transgenic TCR in CD8 T cells. The effects caused by GC-treated DCs were compared to the responses to immunogenic, CpG-activated DCs. Read More

    Sex-related differences in autoimmune-induced lung lesions in MRL/MpJ-fas mice are mediated by the development of mediastinal fat-associated lymphoid clusters.
    Autoimmunity 2017 Aug 30;50(5):306-316. Epub 2017 Jun 30.
    b Laboratory of Anatomy, Department of Biomedical Sciences, Graduate School of Veterinary Medicine , Hokkaido University , Sapporo , Japan.
    MRL/MpJ-Fas (lpr) mice are a model for autoimmune diseases such as systemic lupus erythematosus (SLE). These diseases mainly affect women, with a 10:1 female-to-male ratio, and cause pleuropulmonary lesions. We previously revealed a correlation between mediastinal fat-associated lymphoid cluster (MFALC) development and cellular infiltration in the lungs of lpr male mice; however, we did not report on MFALCs in females. Read More

    Abnormal distribution of AQP4 in minor salivary glands of primary Sjögren's syndrome patients.
    Autoimmunity 2017 Jun 24;50(4):202-210. Epub 2017 Jun 24.
    a Department of Basic Medical Sciences, Neurosciences and Sensory Organs (SMBNOS), Section of Human Anatomy and Histology , University of Bari "Aldo Moro" , Bari , Italy.
    A decreased saliva production occurs in primary Sjögren's syndrome (pSS), an autoimmune disease characterized by oral and ocular dryness due to dysfunction of the lacrimal and salivary glands (SGs). Since water movement is involved in saliva secretion, the expression, localization, and function of the water channels aquaporins (AQPs) have been extensively studied in SGs. To date, the presence of AQP4 remains controversial and ambiguous in human SGs. Read More

    Identification of endothelin-converting enzyme-2 as an autoantigen in autoimmune polyendocrine syndrome type 1.
    Autoimmunity 2017 Jun 30;50(4):223-231. Epub 2017 May 30.
    a Department of Medical Sciences , Uppsala University , Uppsala , Sweden.
    Autoimmune polyendocrine syndrome type 1 (APS1) is a rare monogenic autoimmune disorder caused by mutations in the autoimmune regulator (AIRE) gene. High titer autoantibodies are a characteristic feature of APS1 and are often associated with particular disease manifestations. Pituitary deficits are reported in up to 7% of all APS1 patients, with immunoreactivity to pituitary tissue frequently reported. Read More

    Antiribonuclease H2 antibodies are an immune biomarker for systemic lupus erythematosus.
    Autoimmunity 2017 Jun 27;50(4):241-246. Epub 2017 May 27.
    a Department of Rheumatology , Juntendo University School of Medicine , Tokyo , Japan.
    We previously reported that autoantibodies against the proliferating cell nuclear antigen protein (PCNA)-binding protein chromatin assembly factor-1 (CAF-1) are specifically found in patients with systemic lupus erythematosus (SLE). PCNA and its complex constituents elicit autoimmune responses in patients with SLE, suggesting that autoantibody diversification likely occurs owing to epitope spreading. Therefore, we sought to clarify whether patients with SLE exhibit an autoimmune response to Ribonuclease H2 (RNase H2), another PCNA-binding protein that regulates cell division. Read More

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