2,504 results match your criteria Autoimmunity [Journal]


Whole-exome sequencing in three children with sporadic Blau syndrome, one of them co-presenting with recurrent polyserositis.

Autoimmunity 2020 Jun 29:1-9. Epub 2020 Jun 29.

División de Genética, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social.

Blau syndrome (BS) is a rare, chronic autoinflammatory disease with onset before age 4 and mainly characterised by granulomatous arthritis, recurrent uveitis, and skin rash. Sporadic (also known as early-onset sarcoidosis) or familial BS is caused by gain-of-function mutations in the gene, which encodes for a multi-task protein that plays a crucial role in the innate immune defense. We report on three Mexican patients clinically diagnosed with BS who exhibited a likely pathogenic variant in as revealed by whole-exome sequencing (WES) and Sanger sequencing: two variants (c. Read More

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http://dx.doi.org/10.1080/08916934.2020.1786068DOI Listing

Enhanced expression of human endogenous retroviruses in new-onset type 1 diabetes: Potential pathogenetic and therapeutic implications.

Autoimmunity 2020 Jun 25:1-6. Epub 2020 Jun 25.

Department of Public Health and Pediatric Sciences, University of Turin, Turin, Italy.

Human endogenous retroviruses (HERVs) have been studied and proposed as relevant cofactors in several autoimmune diseases, including type 1 diabetes (T1D), though with controversial results and no study at disease onset. In order to gather further information on the potential role of HERVs in the development of T1D we assessed the transcription levels of pol genes of HERV-H, HERV-K, and HERV-W in peripheral leucocytes from 37 children and adolescents with new-onset T1D and 50 age-matched control subjects. A PCR real time Taqman amplification assay was used to evaluate HERV transcripts with normalisation of the results to glyceraldehyde-3-phosphate dehydrogenase. Read More

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http://dx.doi.org/10.1080/08916934.2020.1777281DOI Listing

Feeding lactobacilli impacts lupus progression in (NZBxNZW)F1 lupus-prone mice by enhancing immunoregulation.

Autoimmunity 2020 Jun 19:1-10. Epub 2020 Jun 19.

Department of Microbiology and Immunology, University of Louisville, Louisville, KY, USA.

Although the relationship between autoimmunity and microorganisms is complex, there is evidence that microorganisms can prevent the development of various autoimmune diseases. Lactobacilli are beneficial gut bacteria that play an important role in immune system development. The goals of this study were to assess the ability of three different strains of lactobacilli ( B255, DSM 17509 and LP299v) to control lupus development/progression in (NZBxNZW)F1 (BWF1) lupus-prone mice before and after disease onset, and identify the mechanisms mediating protection. Read More

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http://dx.doi.org/10.1080/08916934.2020.1777282DOI Listing

LncRNA PlncRNA-1 participates in rheumatoid arthritis by regulating transforming growth factor β1.

Autoimmunity 2020 Jun 16:1-6. Epub 2020 Jun 16.

Department of Orthopedics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, P. R. China.

LncRNA PlncRNA-1(PlncRNA-1) participates in breast cancer by upregulating TGF-β1. It is known that TGF-β1 plays an inhibitory role in the inflammatory responses in rheumatoid arthritis (RA). Therefore, PlncRNA-1 may also participate in RA. Read More

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http://dx.doi.org/10.1080/08916934.2020.1750010DOI Listing

CXCL4 promoted the production of CD4CD25FOXP3treg cells in mouse sepsis model through regulating STAT5/FOXP3 pathway.

Autoimmunity 2020 Jun 13:1-8. Epub 2020 Jun 13.

Department of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, PR China.

CXCL4 plays an essential role in the regulation of multiple immune diseases. However, the underlying role of CXCL4 is still not clear in sepsis. Aim: In the present study, we aimed to investigate the function of CXCL4 in sepsis. Read More

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http://dx.doi.org/10.1080/08916934.2020.1777283DOI Listing

Identification of antigen-specific neutrophils in the tonsils with recurrent acute inflammation.

Autoimmunity 2020 Jun 11:1-8. Epub 2020 Jun 11.

Research Center of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen, China.

The pathogenesis of recurrent acute tonsillitis (Rtn) is to be further investigated. Polymorphonuclear neutrophils (PMN) often associate with the pathogenesis of acute and chronic inflammation. This study aims to identify the antigen-specific PMNs (sPMNs) isolated from the tonsillar tissues with recurrent acute inflammation. Read More

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http://dx.doi.org/10.1080/08916934.2020.1777284DOI Listing

Correction.

Authors:

Autoimmunity 2020 May 26. Epub 2020 May 26.

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http://dx.doi.org/10.1080/08916934.2020.1768697DOI Listing

Decrease in alpha-1 antiproteinase antitrypsin is observed in primary Sjogren's syndrome condition.

Autoimmunity 2020 May 25:1-13. Epub 2020 May 25.

Department of Periodontics, School of Dentistry University of Texas Health Science Center, San Antonio, TX, USA.

Primary Sjogren's syndrome (pSS) is a systemic autoimmune disease that is characterized by the infiltration of immune cells. Although the loss of salivary gland function is a major manifestation observed in pSS, the factors that could promote these changes in salivary gland tissue in pSS is not yet determined. Herein, we provide evidence that loss of alpha1 antiproteinase antitrypsin could contribute to the induction of pSS. Read More

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http://dx.doi.org/10.1080/08916934.2020.1768376DOI Listing

Soluble PD1 levels are increased with disease activity in paediatric onset autoimmune hepatitis and inflammatory bowel disease.

Autoimmunity 2020 May 6:1-8. Epub 2020 May 6.

Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.

Immune mediated liver diseases entail a broad category which are associated with increased morbidity and mortality amongst the paediatric population. Programmed Death 1 (PD1) is an inhibitory receptor mainly expressed by T cells, and when activated shed into plasma as soluble PD1(sPD1). The AIM of this study was to evaluate sPD1 levels in plasma of paediatric patients with Autoimmune Hepatitis (AIH), Primary Sclerosing Cholangitis (PSC), AIH and PSC overlap, Inflammatory Bowel Disease (IBD) alone, and concurrent PSC/IBD and AIH/IBD in order to identify a biomarker to response or predict relapse verses remission. Read More

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http://dx.doi.org/10.1080/08916934.2020.1755964DOI Listing

Simultaneous measurement of twenty-nine circulating cytokines and growth factors in female patients with overt autoimmune thyroid diseases.

Autoimmunity 2020 Apr 25:1-9. Epub 2020 Apr 25.

Division of Endocrinology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.

Cytokines and growth factors participate in immune responses, and the pathogenesis of autoimmune diseases. Herein, we simultaneously examined differential levels of 29 circulating factors to determine their associations in female patients with overt autoimmune thyroid disease (AITD). We enrolled 40 patients with Graves' disease (GD), 20 patients with Hashimoto's thyroiditis (HT), and 14 healthy controls. Read More

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http://dx.doi.org/10.1080/08916934.2020.1755965DOI Listing

Autoantibodies against the autophagic protein microtubule-associated light-chain 3 (LC3): Immunocharacterization of an atypical ANA pattern.

Autoimmunity 2020 Apr 27:1-8. Epub 2020 Apr 27.

Department of Medical Biotechnologies, University of Siena, Siena, Italy.

Autoantibodies to nuclear and cytoplasmic antigens are commonly detected by indirect immunofluorescence (IIF) on HEp-2 cells, and three major staining patterns (nuclear, cytoplasmic, and mitotic) are distinguished. Here, we report an atypical cytoplasmic pattern, not described so far, observed in the serum of a patient with a controversial diagnosis of systemic lupus erythematosus (SLE). Moreover, for the first time, we have revealed the presence of autoantibodies against the microtubule-associated light-chain 3 (LC3) protein, which plays a key role in the autophagic process. Read More

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http://dx.doi.org/10.1080/08916934.2020.1755963DOI Listing

Retroviruses in the pathogenesis of systemic lupus erythematosus: Are they potential therapeutic targets?

Autoimmunity 2020 Jun 23;53(4):177-191. Epub 2020 Apr 23.

Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark.

The pathogenesis of systemic lupus erythematosus (SLE) is characterised by the hyper-activation of immunologic pathways related to the antiviral response. Exogenous and endogenous retroviruses, by integrating their DNA templates in the host cell genome, may epigenetically control the transcription of genes involved in the immune response. Furthermore, their nucleic acids or neo-synthesized proteins could stimulate the sensor molecules placed upstream the inflammatory cascade. Read More

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http://dx.doi.org/10.1080/08916934.2020.1755962DOI Listing

MiR-153-3p induces immune dysregulation by inhibiting PELI1 expression in umbilical cord-derived mesenchymal stem cells in patients with systemic lupus erythematosus.

Autoimmunity 2020 Jun 23;53(4):201-209. Epub 2020 Apr 23.

Department of Hematopathology, The Second Affiliated Hospital of Xi'an Jiaotong University (Xibei Hospital), Xi'an, China.

Mesenchymal stem cells (MSCs) are identified as a promising tool for the treatment of autoimmune diseases, and several microRNAs (miRNAs) are shown to exhibit vital roles in immune diseases. However, their function and mechanism in systemic lupus erythematosus (SLE) is still unclear. The qRT-PCR analysis was employed to investigate level of miR-153-3p. Read More

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http://dx.doi.org/10.1080/08916934.2020.1750011DOI Listing

Nanomedicine-mediated prevention of inflammatory monocytes infiltration ameliorate ovalbumin-induced allergic rhinitis in mouse model.

Autoimmunity 2020 Jun 14;53(4):218-224. Epub 2020 Apr 14.

Department of Otorhinolaryngology, the First Affiliated Hospital, Nanjing Medical University, Nanjing, China.

Th2 immune cells infiltration into nasal mucosa is one of the characters of allergic rhinitis (AR). We aimed to explore whether inhibition of Th2 immune cells infiltration would attenuate AR progression. AR mouse model was established by i. Read More

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http://dx.doi.org/10.1080/08916934.2020.1750009DOI Listing

Assessing vitamin D levels in an anti-DFS70 positive population: New insights emerging.

Autoimmunity 2020 Jun 13;53(4):231-236. Epub 2020 Mar 13.

IReL - Rheumatology Institute of Lucania, San Carlo Hospital, Potenza, Italy.

Anti-dense fine speckled 70 (DFS70) autoantibodies have more often been described in apparently healthy individuals than in patients with systemic autoimmune rheumatic diseases (SARD). The aim of this study was to explore the link between anti-DFS70 autoantibodies and vitamin D (25(OH)D) levels in an Italian adult cohort. Serum samples from 34 (five males and 29 females) anti-DFS70 positive patients (index cases), 34 ANA-negative healthy controls, 34 ANA-positive anti-DFS70 negative SLE patients, both groups age- and gender-matched with the index cases, 23 ANA-positive anti-DFS70 negative healthy blood donors and six female SARD patients showing mixed DFS positive pattern were collected and tested for 25(OH)D levels. Read More

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http://dx.doi.org/10.1080/08916934.2020.1736048DOI Listing

Serum IL-21 levels from celiac disease patients correlates with anti-tTG IgA autoantibodies and mucosal damage.

Autoimmunity 2020 Jun 11;53(4):225-230. Epub 2020 Mar 11.

Department of Experimental Medicine, University of Genova, Genova, Italy.

Coeliac disease is a multifactorial disorder influenced by environmental, genetic and immunological factors. Interleukin (IL)-21 has been linked to an increase disease risk and the serum level of IL-21 seems to be increased in CD compared to a healthy control population. Sera were collected from 160 CD patients, 120 untreated and 40 following a gluten-free diet, and form 45 healthy subjects. Read More

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http://dx.doi.org/10.1080/08916934.2020.1736047DOI Listing

Abnormal expression of BAFF and its receptors in peripheral blood and skin lesions from systemic lupus erythematosus patients.

Autoimmunity 2020 Jun 11;53(4):192-200. Epub 2020 Mar 11.

Hunan Key Laboratory of Medical Epigenomics, Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, China.

Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by abnormal T and B cells. B-cell activating factor (BAFF) has been suggested to play a crucial role in lupus by promoting the proliferation, differentiation, and survival of B cells. Increased serum levels of BAFF have been found in patients with lupus. Read More

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http://dx.doi.org/10.1080/08916934.2020.1736049DOI Listing
June 2020
2.714 Impact Factor

CMA1 is potent prognostic marker and associates with immune infiltration in gastric cancer.

Autoimmunity 2020 Jun 4;53(4):210-217. Epub 2020 Mar 4.

Diabetes Center, Zhejiang Provincial Key Laboratory of Pathophysiology, Institute of Biochemistry and Molecular Biology, School of Medicine, Ningbo University, Ningbo, China.

Chymase 1 (CMA1), a gene known to be expressed in mast cells (MCs), is largely linked to immunity. However, the relationship between CMA1 and prognosis of multiple tumours and tumour-infiltrating lymphocytes (TILs) remains elusive. The differential expressions of CMA1 in different tumours and their corresponding normal tissues were evaluated exploring Tumour Immune Estimation Resource (TIMER) and Oncomine database; the correlation within expression level of CMA1 and outcome of cancer patients was evaluated Kaplan-Meier plotter and Gene Expression Profiling Interactive Analysis (GEPIA) database; the correlation between CMA1 and tumour immune cell infiltration was further investigated by TIMER; additionally, the correlation between CMA1 and gene signature pattern of immune infiltration were checked using TIMER and GEPIA. Read More

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http://dx.doi.org/10.1080/08916934.2020.1735371DOI Listing
June 2020
2.714 Impact Factor

Circular RNAs hsa_circ_0000479 in peripheral blood mononuclear cells as novel biomarkers for systemic lupus erythematosus.

Autoimmunity 2020 May 24;53(3):167-176. Epub 2020 Feb 24.

Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

Circular RNAs (circRNAs) are a class of non-coding RNAs that play a crucial role in diagnosis and prognosis of systemic lupus erythematosus (SLE). However, circRNAs expression profiling in SLE from different reports are different. In this study, 11 circRNAs (hsa_circ_0000479, hsa_circ_0002316, hsa_circ_0000317, hsa_circ_0082688, hsa_circ_0082689, hsa_circ_0087798, hsa_circ_0008529, hsa_circ_0000787, hsa_circ_0021727, hsa_circ_0000175, and hsa_circ_0003694) which were found to be significantly up-regulated in both peripheral blood mononuclear cells (PBMCs) from SLE patients in our previous study, and T cells from SLE patients in previous literature, were chosen for validation by quantitative reverse transcription-polymerase chain reaction in PBMCs from 50 new-onset SLE patients, 24 new-onset rheumatoid arthritis (RA) patients, 24 new-onset ankylosing spondylitis (AS) patients, and 45 age- and sex-matched healthy controls (HC). Read More

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http://dx.doi.org/10.1080/08916934.2020.1728529DOI Listing

DNA methylation changes on immune cells in Systemic Lupus Erythematosus.

Autoimmunity 2020 May 4;53(3):114-121. Epub 2020 Feb 4.

Grupo de Inmunología Celular e Inmunogenética, University of Antioquia, Medellin, Colombia.

DNA methylation as a process that regulates gene expression is crucial in immune cells biology. Global and gene specific methylation changes have been described in autoimmunity, especially in Systemic Lupus Erythematosus. These changes not only contribute to the understanding of the disease, but also some have been proposed as diagnostic or disease activity biomarkers. Read More

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http://dx.doi.org/10.1080/08916934.2020.1722108DOI Listing

Identification of key biomolecules in rheumatoid arthritis through the reconstruction of comprehensive disease-specific biological networks.

Autoimmunity 2020 May 3;53(3):156-166. Epub 2020 Feb 3.

Department of Bioengineering, Faculty of Engineering, Adana Alparslan Turkes Science and Technology University, Adana, Turkey.

Rheumatoid arthritis (RA) frequently seen chronic synovial inflammation causing joint destruction, chronic disability and reduced life expectancy. The pathogenesis of RA is not completely known. In this study, several gene expression data including synovial tissue and macrophages from synovial tissues were integrated with a holistic perspective and the molecular targets and signatures in RA were determined. Read More

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http://dx.doi.org/10.1080/08916934.2020.1722107DOI Listing

, , and gene interactions are associated with severity of rheumatoid arthritis: A pilot study.

Autoimmunity 2020 03 29;53(2):95-101. Epub 2020 Jan 29.

Department of Biology, Federal Rural University of Pernambuco, Recife, Brazil.

Rheumatoid arthritis (RA) is an autoimmune disease which can lead to progressive and functional disability. Literature data suggest that some inflammatory proteins are dysregulated in RA patients and its genetic polymorphisms may contribute to the aetiology and pathogenesis of disease in different ethnic groups. Polymorphisms in and genes were studied in different populations with RA, but the analysis indicated contradictory results. Read More

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http://dx.doi.org/10.1080/08916934.2019.1710831DOI Listing

Annexin-coated particles induce antigen-specific immunosuppression.

Autoimmunity 2020 03 14;53(2):86-94. Epub 2020 Jan 14.

Division of Immunogenetics, German Cancer Research Center, Heidelberg, Germany.

Apoptotic cells mediate the development of tolerogenic dendritic cells (DC) and thus facilitate induction and maintenance of peripheral tolerance. Following the identification of the evolutionary conserved annexin core domain (Anx) as a specific signal on apoptotic cells which antagonises Toll-like receptor (TLR) signalling, we examined whether the tolerogenic capacity of Anx can be exploited to downregulate antigen-specific immune responses. The treatment of bone marrow-derived dendritic cells (BMDC) with particles harbouring Anx as well as the model antigen ovalbumin (OVA) attenuated the response of OVA-specific OT-II T cells. Read More

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http://dx.doi.org/10.1080/08916934.2019.1710134DOI Listing

Human antimicrobial peptides in autoimmunity.

Autoimmunity 2020 May 8;53(3):137-147. Epub 2020 Jan 8.

Department of General Pathology and Pathophysiology, Institute of Experimental Medicine, Saint Petersburg, Russia.

Antimicrobial peptides (AMPs) were firstly discovered as cytotoxic substances that killed bacteria. Later they were described as biologically active peptides that are able not only to kill invaders but also to modulate host immunity. In particular, it is shown that human antimicrobial peptides are able to influence the activity of different innate and adaptive immunity components, thus, obviously, they also participate in autoimmune processes. Read More

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http://dx.doi.org/10.1080/08916934.2020.1711517DOI Listing

Identifying the differentially expressed microRNAs in autoimmunity: A systemic review and meta-analysis.

Autoimmunity 2020 May 6;53(3):122-136. Epub 2020 Jan 6.

Hunan Key Laboratory of Medical Epigenomics, Department of Dermatology, Central South University, Changsha, China.

The evidence indicates that microRNAs (miRNAs) can regulate gene expression and play an important role in the pathogenesis of autoimmune diseases, yet studies on expression profiles of miRNAs are still inconclusive. Our objective is to identify miRNAs that demonstrate enduring differential expression on autoimmune diseases. A systemic review and meta-analysis were performed by analysing the expression profile of miRNAs in several types of autoimmune disease, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and type-1 diabetes (T1D). Read More

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http://dx.doi.org/10.1080/08916934.2019.1710135DOI Listing
May 2020
2.714 Impact Factor

T-cell specific upregulation of Sema4A as risk factor for autoimmunity in systemic lupus erythematosus and rheumatoid arthritis.

Autoimmunity 2020 03 26;53(2):65-70. Epub 2019 Dec 26.

Department of Genetics, Federal University of Pernambuco, Recife, Brazil.

The aim of the present study was to evaluate the impact of genetic variants on expression of sema4A protein and its relation to autoimmunity development in Systemic Lupus Erythematosus and Rheumatoid Arthritis patients. A total of 541 SLE patients, 390 RA patients and 607 healthy individuals were genotyped. We also assessed mRNA expression from whole blood cells and the in vitro protein production from resting and activated T lymphocytes as well as mature dendritic cells from healthy individuals stratified according to their genotypes for SLE/RA associated variants. Read More

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http://dx.doi.org/10.1080/08916934.2019.1704273DOI Listing

The pathological role of B cells in systemic lupus erythematosus: From basic research to clinical.

Autoimmunity 2020 03 26;53(2):56-64. Epub 2019 Dec 26.

Department of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, Hunan, China.

Systemic lupus erythematosus (SLE) is an autoimmune disease that often occurs in females of child-bearing age. It involves multiple systems and severely threatens human life. One of the typical characteristics of SLE is the formation of immune complexes with autoantibodies produced by B cells that target various autoantigens, thus indicating the pivotal role of B cells in the pathogenesis of SLE. Read More

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http://dx.doi.org/10.1080/08916934.2019.1700232DOI Listing
March 2020
2.714 Impact Factor

A novel 4-dimensional live-cell imaging system to study leukocyte-endothelial dynamics in ANCA-associated vasculitis.

Autoimmunity 2020 May 23;53(3):148-155. Epub 2019 Dec 23.

Renal Unit, Aberdeen Royal Infirmary, Aberdeen, Scotland.

Neutrophils, monocytes and the endothelium are critical to ANCA-associated vasculitis (AAV) pathogenesis. This study aimed to develop a 4-dimensional (4D) live-cell imaging system that would enable investigation of spatial and temporal dynamics of these cells in health and disease. We further aimed to validate this system using autologous donor serum from AAV patients and polyclonal ANCA IgG, as well as exploring its potential in the pre-clinical testing of putative therapeutic compounds. Read More

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http://dx.doi.org/10.1080/08916934.2019.1704274DOI Listing

The -675 4G/5G polymorphism confers genetic susceptibility to systemic lupus erythematosus, its clinical manifestations, and comorbidities in Mexican-Mestizo population.

Autoimmunity 2020 03 12;53(2):71-77. Epub 2019 Dec 12.

Instituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, México.

Systemic lupus erythematosus (SLE) involves a broad range of factors that contribute to the development of the disease and its comorbidities. Genetic predisposition influences the development of SLE, and the -675 4G/5G polymorphism has been associated with several pathologies with a chronic inflammatory component. Our objective was to investigate the genetic association between the -675 4G/5G polymorphism with SLE, its clinical manifestations, and comorbidities in a Mexican-Mestizo population. Read More

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http://dx.doi.org/10.1080/08916934.2019.1700957DOI Listing

Deciphering crucial genes in coeliac disease by bioinformatics analysis.

Autoimmunity 2020 03 6;53(2):102-113. Epub 2019 Dec 6.

Department of Biology Sciences, Shahid Rajaee Teacher Training University, Tehran, Iran.

Coeliac disease (CD) is a chronic autoimmune disease that is characterized by malabsorption in sensitive individuals. CD is triggered by the ingestion of grains containing gluten. CD is concomitant with several other disorders, including dermatitis herpetiformis, selective IgA deficiency, thyroid disorders, diabetes mellitus, various connective tissue disorders, inflammatory bowel disease, and rheumatoid arthritis. Read More

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http://dx.doi.org/10.1080/08916934.2019.1698552DOI Listing
March 2020
5 Reads
2.714 Impact Factor

Low frequency of IL-10-producing B cells and high density of ILC2s contribute to the pathological process in Graves' disease, which may be related to elevated-TRAb levels.

Autoimmunity 2020 03 6;53(2):78-85. Epub 2019 Dec 6.

International Genomics Research Center (IGRC), Jiangsu University, Zhenjiang, China.

IL-10-producing B Cells (B10) is a functionally defined regulatory Bcell subset. It plays an important role in the control of inflammation and autoimmune diseases, although it is present at low numbers in peripheral blood. Graves' disease is an autoimmune disease characterized by the production of autoantibodies such as TRAb. Read More

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http://dx.doi.org/10.1080/08916934.2019.1698553DOI Listing

Therapeutic effect of mesenchymal stem cell on Hashimoto's thyroiditis in a rat model by modulating Th17/Treg cell balance.

Autoimmunity 2020 02 3;53(1):35-45. Epub 2019 Dec 3.

Department of Diabetes Endocrinology, the First Affiliated Hospital of Yunnan, University of Traditional Chinese Medicine, Kunming, China.

The autoimmune condition Hashimoto's thyroiditis (HT) is a disease wherein lymphocytes mediate the autoimmune damage and destruction of the thyroid gland. There are currently no effective means of treating HT, with the primary strategies of thyroid hormone therapy, surgery, or immunomodulatory therapy being associated with serious risks and side effects. There is thus a clear and urgent need to identify novel treatments for HT. Read More

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http://dx.doi.org/10.1080/08916934.2019.1697689DOI Listing
February 2020

Lower proportion of CD19IL-10 and CD19CD24CD27 but not CD1dCD5CD19CD24CD27 IL-10 B cells in children with autoimmune thyroid diseases.

Autoimmunity 2020 02 2;53(1):46-55. Epub 2019 Dec 2.

Department of Pediatric Endocrinology, Diabetology with Cardiology Division, Medical University of Bialystok, Bialystok, Poland.

As it is generally known, regulatory B cells (Bregs) control inflammation and autoimmunity. The significance of Bregs in the population of children with autoimmune thyroid diseases (AITD) still offers plenty of potential to explore. The aim of this study was to estimate the expression of Bregs (phenotype CD19CD24CD27IL-10, CD19IL-10, CD1dCD5CD19IL-10 and CD1dCD5CD19CD24CD27) in a paediatric cohort with AITD and in health controls. Read More

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http://dx.doi.org/10.1080/08916934.2019.1697690DOI Listing
February 2020

Effect of high mobility group box 1 on Toll-like receptor 9 in B cells in myeloperoxidase-ANCA-associated vasculitis.

Autoimmunity 2020 02 2;53(1):28-34. Epub 2019 Dec 2.

Department of Medicine, Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, Beijing, China.

High mobility group box 1 (HMGB1) played pathogenic role in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Recent findings demonstrated that Toll-like receptor 9 (TLR9) was involved in B cell tolerance breaking of autoimmune disease, including AAV. Here, we investigated the effect of HMGB1 on TLR9 in B cells of AAV. Read More

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http://dx.doi.org/10.1080/08916934.2019.1696777DOI Listing
February 2020

Diagnostic performance of aPS/PT antibodies in neuropsychiatric lupus and cardiovascular complications of systemic lupus erythematosus.

Autoimmunity 2020 02 29;53(1):21-27. Epub 2019 Nov 29.

Università Vita-Salute San Raffaele, Milan, Italy.

Systemic lupus erythematosus (SLE) is associated with a constellation of complications affecting multiple organs, including neuropsychiatric manifestations (NPSLE) and ischaemic events, leading to increased long-term morbidity. Antiphospholipid antibodies (aPL) are a major determinant of vascular inflammation and thromboembolic risk. The diagnostic role of anti-phosphatidylserine/prothrombin (aPS/PT) antibodies in this setting is incompletely defined. Read More

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http://dx.doi.org/10.1080/08916934.2019.1696778DOI Listing
February 2020
4 Reads
2.714 Impact Factor

Th1, Th2, and Th17 cytokines in systemic lupus erythematosus.

Autoimmunity 2020 02 27;53(1):8-20. Epub 2019 Nov 27.

Department of Immunology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kota Bharu, Malaysia.

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the breakdown of immune tolerance leading to excessive inflammation and tissue damage. Imbalance in the levels of cytokines represents one of the multifactorial causes of SLE pathogenesis and it contributes to disease severity. Deregulated levels of T helper type 1 (Th1), type 2 (Th2), and type 17 (Th17) cytokines have been associated with autoimmune inflammation. Read More

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http://dx.doi.org/10.1080/08916934.2019.1693545DOI Listing
February 2020

Association study between X-linked susceptibility genes and clinical features in Chinese female patients with systemic lupus erythematosus.

Autoimmunity 2019 Nov - Dec;52(7-8):289-293. Epub 2019 Nov 11.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China.

Recent large-scale genetic association studies have identified that several single nucleotide polymorphisms (SNPs) on X chromosome are correlated with risk of systemic lupus erythematosus (SLE) in Chinese population. The aim of this study was to estimate association between these loci and clinical features in female patients with SLE. Six SNPs identified in previous studies were genotyped. Read More

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http://dx.doi.org/10.1080/08916934.2019.1688792DOI Listing

Autoantigen-specific B cells and plasma cells are prominent in areas of fatty infiltration in salivary glands of patients with primary Sjögren's syndrome.

Autoimmunity 2019 Nov - Dec;52(7-8):242-250. Epub 2019 Oct 30.

Department of Oral Surgery and Oral Medicine, University of Oslo, Oslo, Norway.

Salivary and lacrimal gland involvement is a characteristic feature of primary Sjögren's syndrome (pSS), where tissue destruction is mediated by mononuclear cell infiltration, resulting in lacrimal and salivary gland impairment. We have previously shown distinct prevalence of adipose tissue replacement in the minor salivary gland tissue from pSS patients. The salivary gland microenvironment was further examined through microarray analysis, identifying signalling pathways that promoted adipose tissue development, inflammation, and lymphoma. Read More

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http://dx.doi.org/10.1080/08916934.2019.1684475DOI Listing

Gene-gene interaction and association of Wnt/Β-catenin signalling pathway gene polymorphisms with ankylosing spondylitis susceptibility in the Chinese Han population.

Autoimmunity 2019 Nov - Dec;52(7-8):281-288. Epub 2019 Oct 26.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China.

To explore the genetic interaction between Wnt/β-catenin signalling pathway genes and ankylosing spondylitis (AS) in the Chinese population. Six single-nucleotide polymorphisms (SNPs) in DKK1, LRP5, LRP6, and SOST genes were genotyped in 673 AS patients and 687 healthy controls by using SNPs can Technic. Single marker genetic association analysis was performed. Read More

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http://dx.doi.org/10.1080/08916934.2019.1681984DOI Listing
July 2020
2.714 Impact Factor

Bisphenol A modified DNA: A possible immunogenic stimulus for anti-DNA autoantibodies in systemic lupus erythematosus.

Autoimmunity 2019 Nov - Dec;52(7-8):272-280. Epub 2019 Oct 26.

Department of Medical Biochemistry, Qassim University, Buraidah, KSA.

Anti-DNA antibodies are now considered as a universal diagnostic feature for the patients with systemic lupus erythematosus (SLE) but the mechanism(s) involved in the generation of these autoantibodies remains to be investigated. Bisphenol A (BPA) is a synthetic phenol extensively used in the manufacturing of polycarbonated plastics. Upon mixing in the diet, it causes several health hazards. Read More

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http://dx.doi.org/10.1080/08916934.2019.1683545DOI Listing
July 2020
1 Read

Long non coding RNA H19: An emerging therapeutic target in fibrosing diseases.

Autoimmunity 2020 02 24;53(1):1-7. Epub 2019 Oct 24.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China.

Fibrosis is characterised by excessive deposition of the extracellular matrix (ECM) and develops because of fibroblast differentiation during the process of inflammation. There are few effective treatment options for this diseases due to the aetiology of fibrosis is not completely clarified. Long non-coding RNAs (lncRNAs), a type of ncRNA with a length of greater than 200 nucleotides without evident protein coding function, are important regulators of most biological and pathological processes, including participation, regulation or mediation of disease development. Read More

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http://dx.doi.org/10.1080/08916934.2019.1681983DOI Listing
February 2020
1 Read

Diagnostic value of 18-F fluorodeoxyglucose PET/CT and bone scan in Schnitzler syndrome.

Autoimmunity 2019 Nov - Dec;52(7-8):264-271. Epub 2019 Oct 24.

Internal Medicine Department, Rennes University Hospital, Rennes, France.

Schnitzler syndrome is an auto-inflammatory disease defined by chronic urticarial eruption and monoclonal gammopathy. F fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) is often performed, but its utility in Schnitzler syndrome has not been specifically investigated. The aim of this study was to determine whether PET/CT is informative in the diagnosis and follow-up of Schnitzler syndrome relative to other imaging techniques, including bone scans. Read More

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http://dx.doi.org/10.1080/08916934.2019.1680649DOI Listing
July 2020
1 Read

COX-2 induces T cell accumulation and IFN-γ production during the development of chromium allergy.

Autoimmunity 2019 Aug - Sep;52(5-6):228-234. Epub 2019 Oct 6.

Department of Advanced Prosthetic Dentistry, Graduate School of Dentistry, Tohoku University, Sendai, Japan.

Chromium (Cr) is commonly added into various metal alloys to improve some mechanical properties such as corrosion resistance, strength, and workability. However, Cr is also known to be a metal allergen for some individuals. Metal allergy is a T cell-mediated disease with symptoms of inflammation and swelling that involve inflammatory cytokines and prostaglandins. Read More

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http://dx.doi.org/10.1080/08916934.2019.1662404DOI Listing
October 2019
1 Read

Blau syndrome with a rare mutation in exon 9 of gene.

Autoimmunity 2019 Nov - Dec;52(7-8):256-263. Epub 2019 Sep 26.

Faculty of Medicine, Department of Medical Genetic, COMU University, Canakkale, Turkey.

Blau syndrome is an autosomal dominant rare disease caused by mutations in gene. Less than 200 patients published with Blau Syndrome Worldwide. We reported a 41-year old female Turkish patient diagnosed as Blau syndrome. Read More

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http://dx.doi.org/10.1080/08916934.2019.1671375DOI Listing
July 2020
2 Reads

Association of gene methylation in peripheral blood cells with the development and prognosis of autoimmune thyroid diseases.

Autoimmunity 2019 Nov - Dec;52(7-8):251-255. Epub 2019 Sep 25.

Department of Biomedical Informatics, Division of Health Sciences, Osaka University Graduate School of Medicine, Suita, Japan.

Autoimmune thyroid diseases (AITDs), including Hashimoto's disease (HD) and Graves' disease (GD), are archetypes of organ-specific autoimmune diseases, but the prognosis of patients with AITD varies. Autoimmune diseases, including AITDs, are believed to develop in response to both genetic and environmental factors. Interleukin (IL)-6 plays a major role in B cell differentiation and T cell proliferation, and methylation of the gene is associated with IL-6 production. Read More

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http://dx.doi.org/10.1080/08916934.2019.1669568DOI Listing
July 2020
1 Read

IP-10 and MCP-1 gene polymorphisms in Chinese patients with chronic immune thrombocytopenia.

Autoimmunity 2019 Aug - Sep;52(5-6):235-241. Epub 2019 Sep 18.

State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.

Aberrant Th1/Th2 polarization is considered to play a crucial role in the abnormal immune state of primary immune thrombocytopenia (ITP). IFN-γ-inducible protein of 10 kilodaltons (IP-10) and Monocyte chemoattractant protein-1 (MCP-1) gene are involved in enhancing the Th1 and Th2 immune response, respectively. In this study we investigated the distributions of IP-10 (-201 G/A) and MCP-1 (-2518 A/G) polymorphisms in 323 patients with chronic ITP and 255 healthy controls by polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP). Read More

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http://dx.doi.org/10.1080/08916934.2019.1666370DOI Listing
September 2019

The gene mutations and subtelomeric DNA methylation in immunodeficiency, centromeric instability and facial anomalies syndrome.

Autoimmunity 2019 Aug - Sep;52(5-6):192-198. Epub 2019 Sep 2.

Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang, China.

Immunodeficiency, centromeric instability and facial anomalies syndrome (ICF) is a rare autosomal recessive disorder, which is characteristic of a severe impairment of immunity. In the genetic aspect, ICF is featured with mutations primarily located in the specific genes ( for ICF1, for ICF2, for ICF3, and for ICF4). The subtelomeric region is defined as 500 kb at the terminal of each autosomal arm. Read More

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http://dx.doi.org/10.1080/08916934.2019.1657846DOI Listing
September 2019
4 Reads
2.714 Impact Factor

Vasculitis and crescentic glomerulonephritis in a newly established congenic mouse strain derived from ANCA-associated vasculitis-prone SCG/Kj mice.

Autoimmunity 2019 Aug - Sep;52(5-6):208-219. Epub 2019 Sep 2.

Asia International Institute of Infectious Disease Control, Teikyo University, Tokyo, Japan.

Lupus nephritis (LN) is the secondary glomerulonephritis (GN) involved in systemic lupus erythematosus (SLE) and a typical immune complex-type GN. Antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is an autoimmune disease characterized by systemic vasculitis and pauci-immune-type crescentic glomerulonephritis (CrGN) with ANCA production. Human AAV causes death due to lung haemorrhage and end-stage renal disease, for which renal replacement therapies are necessary. Read More

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http://dx.doi.org/10.1080/08916934.2019.1658191DOI Listing
September 2019
2 Reads

Impacts of GFP-FoxP3 regulatory T cells on lupus hallmarks differ by genetic background and type of GFP knock-in.

Autoimmunity 2019 Aug - Sep;52(5-6):199-207. Epub 2019 Aug 30.

Department of Anatomy and Cell Biology, Seoul National University College of Medicine, Seoul, Republic of Korea.

FoxP3 reporter mice expressing green fluorescence protein (GFP) have been used as a very convenient tool to investigate the impact of regulatory T (Treg) cells on pathogenesis in autoimmune diseases. Here, we found that GFP-FoxP3 knock-in (KI) mice showed alterations in the production of anti-nuclear autoantibodies (ANAs) and nephritis with different extent, depending on the presence or absence of lupus susceptibility gene locus 1 () and KI method: contrasting with B6.. Read More

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http://dx.doi.org/10.1080/08916934.2019.1657098DOI Listing
August 2019
4 Reads

Local intra-articular injection of rapamycin inhibits NLRP3 activity and prevents osteoarthritis in mouse DMM models.

Autoimmunity 2019 06 13;52(4):168-175. Epub 2019 Aug 13.

The General Hospital of Ningxia Medical University, Ningxia Medical University , Yinchuan , PR China.

This study investigated the influence of autophagy on the expression of Collagen type II and light chain 3 (LC-3) in the articular cartilage of osteoarthritis (OA) models. The expression of OA associated biomarkers namely Matrix metalloproteinase (MMP-13), NOD-, LRR- and pyrin domain-containing 3 (NLRP3) induced by destabilizing the medial meniscus operation (DMM) were also investigated. A total of 60 C57BL/6 mice were divided into (1) control; (2) DMM2; (3) DMM8; (4) rapamycin 2 weeks; and (5) rapamycin 8 weeks groups. Read More

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http://dx.doi.org/10.1080/08916934.2019.1643844DOI Listing
June 2019
3 Reads