216 results match your criteria Autoimmune diseases[Journal]


Therapeutic Plasma Exchange as Management of Complicated Systemic Lupus Erythematosus and Other Autoimmune Diseases.

Autoimmune Dis 2019 11;2019:5350960. Epub 2019 Mar 11.

Grupo de Investigación en Reumatología, Autoinmunidad y Medicina Traslacional (GIRAT), Fundación Valle del Lili and Universidad Icesi, Cali, Colombia.

Introduction: Autoimmune diseases include a diverse and complex group of pathologies with a broad clinical spectrum due to the production of autoantibodies, which generates multisystemic compromise. Therapeutic plasma exchange (TPE) is a good additive treatment for immunosuppression due to its action over the autoantibodies.

Objectives: To describe the main clinical characteristics and outcomes of patients with systemic lupus erythematosus and other systemic autoimmune diseases managed with TPE. Read More

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http://dx.doi.org/10.1155/2019/5350960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432729PMC
March 2019
1 Read

Identification of Levels of Serum Amyloid A and Apolipoprotein A1 in Serum Proteomic Analysis of Neuropsychiatric Systemic Lupus Erythematosus Patients.

Autoimmune Dis 2018 21;2018:6728541. Epub 2018 Nov 21.

Universidad de Antioquia, Facultad de Medicina, Grupo de Inmunología Celular e Inmunogenética (GICIG), Medellín, Colombia.

Neuropsychiatric Systemic Lupus Erythematosus (NPSLE) has multiple pathogenic mechanisms that cause diverse manifestations and whose diagnosis is challenging because of the absence of appropriate diagnostic tests. In the present study the application of proteomics using two-dimensional electrophoresis (2D) and mass spectrometry (MS) allowed the comparison of the protein profile of the serum low and high abundance protein fractions of NPSLE patients (NPSLE group) and SLE without neuropsychiatric syndromes (SLE group), Neuropsychiatric syndromes not associated with SLE (NPnoSLE groups), and healthy controls (CTRL group). The gels obtained were digitalized and analyzed with the PDQuest software. Read More

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http://dx.doi.org/10.1155/2018/6728541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280257PMC
November 2018
1 Read

Nail Involvement in Patients with Psoriatic Arthritis in Northern Iran.

Autoimmune Dis 2018 15;2018:4608490. Epub 2018 Oct 15.

Department of Dermatology, Skin Research Center, Guilan University of Medical Sciences, Rasht, Iran.

Background: Psoriatic arthritis (PsA) results in an increased burden of psoriasis and impairs both quality of life and an individual's functional capacity. The relationship between nail involvement and PsA in psoriasis is not fully characterized.

Aim: To evaluate the frequency and characteristics of nail involvement in psoriatic patients and to assess the relationship with joint involvement. Read More

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http://dx.doi.org/10.1155/2018/4608490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205104PMC
October 2018
34 Reads

Relationships among Antibodies against Extractable Nuclear Antigens, Antinuclear Antibodies, and Autoimmune Diseases in a Brazilian Public Hospital.

Autoimmune Dis 2018 30;2018:9856910. Epub 2018 Sep 30.

Laboratory of Applied Immunology, Center of Medical and Pharmaceutical Sciences, Western Parana State University, Cascavel/PR 85819-110, Brazil.

One characteristic of autoimmune diseases (ADs) is the production of autoantibodies for extractable nuclear autoantigens, which may aid in the discrimination of the different types of autoimmune diseases and is related to different antinuclear antibody (ANA) patterns. The present study verified the profile of patient samples tested for extractable nuclear antigens (ENA) antibodies in a public hospital and correlated the ENA results with ANA patterns and patient diagnoses. The study reviewed data in the medical records of patients who underwent anti-ENA tests at a public hospital in the West of the State of Paraná from February 2011 to January 2017. Read More

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http://dx.doi.org/10.1155/2018/9856910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186355PMC
September 2018
3 Reads

Role of Mast Cells in Oral Lichen Planus and Oral Lichenoid Reactions.

Autoimmune Dis 2018 17;2018:7936564. Epub 2018 Jan 17.

Department of Oral Pathology, Faculty of Dental Sciences, Sri Ramachandra Medical College and Research Institute (Deemed to Be University), Chennai, India.

Introduction: Oral lichen planus (OLP) is a chronic T cell mediated disease of oral mucosa, skin, and its appendages with a prevalence of 0.5 to 2.6% worldwide. Read More

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http://dx.doi.org/10.1155/2018/7936564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822832PMC
January 2018
4 Reads

Anti-Myeloperoxidase Antibodies Associate with Future Proliferative Lupus Nephritis.

Autoimmune Dis 2017 24;2017:1872846. Epub 2017 Dec 24.

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, 6707 Democracy Blvd, Bethesda, MD 20892, USA.

Background: The subclinical pathophysiology of proliferative lupus nephritis (PLN) has not been fully elucidated. Myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA) is associated with PLN, but prediagnostic levels have not been reported.

Methods: We performed a retrospective case-control Department of Defense Serum Repository (DoDSR) study comparing MPO-ANCA levels in longitudinal prediagnostic serum samples for 23 biopsy confirmed proliferative lupus nephritis (PLN) patients to DoDSR identified age, sex, race, and age of serum matched healthy and SLE without LN disease controls. Read More

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http://dx.doi.org/10.1155/2017/1872846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757094PMC
December 2017
1 Read

Frequency and Type of Hepatic and Gastrointestinal Involvement in Juvenile Systemic Lupus Erythematosus.

Autoimmune Dis 2017 29;2017:8097273. Epub 2017 Nov 29.

Children's Medical Center, Pediatrics Center of Excellence, Tehran, Iran.

Background: Systemic lupus erythematosus (SLE) is a frequent rheumatology disorder among children. Since hepatic involvement is a common systemic manifestation in lupus, the frequency and type of hepatic involvement were determined in pediatric cases of SLE admitted to Children's Medical Hospital from 2005 to 2014.

Methods And Patients: In this observational case-series study, 138 pediatric cases of SLE were admitted in Children's Medical Center (a pediatric rheumatology referral center in Tehran, Iran) enrolled from 2005 to 2014 and the outcomes, frequency, and type of hepatic involvement were assessed among them. Read More

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http://dx.doi.org/10.1155/2017/8097273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727633PMC
November 2017
14 Reads

Increased Whole Blood Viscosity Is Associated with the Presence of Digital Ulcers in Systemic Sclerosis: Results from a Cross-Sectional Pilot Study.

Autoimmune Dis 2017 29;2017:3529214. Epub 2017 Nov 29.

Division of Rheumatology, University of Illinois at Chicago, Chicago, IL, USA.

Objective: To investigate the role of whole blood viscosity in digital ulcer (DU) development in patients with diffuse and limited Systemic sclerosis.

Methods: A convenience sample of patients with Systemic sclerosis (SSc) was selected from the adult Rheumatology clinic at the University of Chicago. The study group consisted of patients with SSc (with ulcers present, a history of ulcers, and no ulcers); the control group consisted of matched healthy Rheumatology clinic staff. Read More

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http://dx.doi.org/10.1155/2017/3529214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727567PMC
November 2017
11 Reads

Clinical and Immunologic Profiles in Incomplete Lupus Erythematosus and Improvement with Hydroxychloroquine Treatment.

Autoimmune Dis 2016 28;2016:8791629. Epub 2016 Dec 28.

Department of Public Health Sciences, Penn State University, College of Medicine, Hershey, PA, USA.

. The study goals were to evaluate performance of SLE classification criteria, to define patients with incomplete lupus erythematosus (ILE), and to probe for features in these patients that might be useful as indicators of disease status and hydroxychloroquine response. . Read More

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https://www.hindawi.com/journals/ad/2016/8791629/
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http://dx.doi.org/10.1155/2016/8791629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225311PMC
December 2016
33 Reads

GAKG-RGEKG an Epitope That Provokes Immune Cross-Reactivity between sp. and Human Collagen: Evidence of Molecular Mimicry in Chronic Periodontitis.

Autoimmune Dis 2016 25;2016:5472320. Epub 2016 Dec 25.

Departamento de Periodoncia, Facultad de Odontología, Universidad Católica de Santa María, Urb. San José s/n Umacollo, Arequipa, Peru.

Periodontal disease afflicts 20% of world population. This process usually occurs in the form of being lethargic and chronic, and consequently this disease is known as chronic process. All chronic diseases constantly cause activation of the immune system, and therefore the presentation of microbial peptides which are presented to lymphocytes by professional antigen presenting cells can present microbial peptides very similar to important structures of human economy causing autoimmune diseases, process known as molecular mimicry. Read More

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http://dx.doi.org/10.1155/2016/5472320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220385PMC
December 2016

Infiltrating CD16 Are Associated with a Reduction in Peripheral CD14CD16 Monocytes and Severe Forms of Lupus Nephritis.

Autoimmune Dis 2016 13;2016:9324315. Epub 2016 Dec 13.

Grupo de Inmunología Celular e Inmunogenética, GICIG, Universidad de Antioquía, Medellín, Colombia; Grupo de Reumatología, Universidad de Antioquía, Medellín, Colombia.

Our aim was to characterize glomerular monocytes (Mo) infiltration and to correlate them with peripheral circulating Mo subsets and severity of lupus nephritis (LN). . We evaluated 48 LN biopsy samples from a referral hospital. Read More

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http://dx.doi.org/10.1155/2016/9324315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187455PMC
December 2016
10 Reads

Presence of DQ2.2 Associated with DQ2.5 Increases the Risk for Celiac Disease.

Autoimmune Dis 2016 30;2016:5409653. Epub 2016 Nov 30.

Graduate Program in Medical Sciences, University of Brasília School of Medicine, 70.900.910 Brasília, DF, Brazil; Research Laboratory for Celiac Disease, University of Brasília School of Medicine, 70.900.910 Brasília, DF, Brazil; Graduate Program in Health Sciences, University of Brasília School of Health Sciences, 70.900.910 Brasília, DF, Brazil; Department of Pharmaceutical Sciences, University of Brasília School of Health Sciences, 70.900.910 Brasília, DF, Brazil.

Celiac disease (CD) is a genetically determined immune-mediated disorder in which gluten immunogenic peptides are presented to CD4 T cells by HLA-DQ2.5, DQ8, DQ2.2, and their combinations. Read More

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http://dx.doi.org/10.1155/2016/5409653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155080PMC
November 2016
3 Reads

The Prevalence of Skin and Soft Tissue Infections in Patients with Pemphigus.

Autoimmune Dis 2016 9;2016:7529078. Epub 2016 Oct 9.

Department of Statistics, Health Faculty, Kashan University of Medical Sciences, Kashan, Iran.

Pemphigus vulgaris are autoimmune blistering diseases that may result in significant morbidity and death. Immunosuppressive therapy of pemphigus vulgaris would predispose the patients to infections. The aim of this study was to assess the prevalence of infection and gene in patients with pemphigus admitted to dermatology clinic. Read More

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http://dx.doi.org/10.1155/2016/7529078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075296PMC
October 2016

[(18)F]-Fluoro-Deoxy-Glucose Positron Emission Tomography Scan Should Be Obtained Early in Cases of Autoimmune Encephalitis.

Autoimmune Dis 2016 31;2016:9450452. Epub 2016 Jul 31.

Department of Adult Neurology, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195-5245, USA; Epilepsy Center, Neurologic Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195-5245, USA.

Introduction. Autoimmune encephalitis (AE) is a clinically challenging diagnosis with nonspecific neurological symptoms. Prompt diagnosis is important and often relies on neuroimaging. Read More

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http://dx.doi.org/10.1155/2016/9450452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983330PMC

Correlation of Serum Soluble Interleukin-7 Receptor and Anti-C1q Antibody in Patients with Systemic Lupus Erythematosus.

Autoimmune Dis 2016 16;2016:8252605. Epub 2016 Mar 16.

Institute of Human Stem Cell Research at General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, China.

Background. Serum concentrations of soluble interleukin-7 receptor (sIL-7R) and anti-C1q antibody have recently been identified as unique serological markers for lupus nephritis (LN) in patients with systemic lupus erythematosus (SLE). In this study, we evaluated the correlation of serum sIL-7R and anti-C1q in SLE patients. Read More

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http://dx.doi.org/10.1155/2016/8252605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812203PMC
April 2016
23 Reads

Increased Circulating Th17 Cells, Serum IL-17A, and IL-23 in Takayasu Arteritis.

Autoimmune Dis 2016 13;2016:7841718. Epub 2016 Mar 13.

Department of Clinical Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Rae Bareily Road, Lucknow, Uttar Pradesh 226 014, India.

Introduction. Th17, γδT, NK, and NKT cells in peripheral blood and serum IL-17 and IL-23 in Takayasu arteritis (TA) were measured and correlated with disease activity. Methods. Read More

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http://dx.doi.org/10.1155/2016/7841718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808531PMC
April 2016
44 Reads
5 Citations

Mechanism of Xinfeng Capsule on Adjuvant-Induced Arthritis via Analysis of Urinary Metabolomic Profiles.

Autoimmune Dis 2016 18;2016:5690935. Epub 2016 Feb 18.

College of Pharmacy, Anhui University of Chinese Medicine, 103 Meishan Road, Hefei 230038, China.

We aimed to explore the potential effects of Xinfeng capsule (XFC) on urine metabolic profiling in adjuvant-induced arthritis (AA) rats by using gas chromatography time-of-flight mass spectrometry (GC-TOF/MS). GC-TOF/MS technology was combined with multivariate statistical approaches, such as principal component analysis (PCA), partial least squares discriminant analysis (PLS-DA), and orthogonal projections to latent structures discriminant analysis (OPLS-DA). These methods were used to distinguish the healthy group, untreated group, and XFC treated group and elucidate potential biomarkers. Read More

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http://dx.doi.org/10.1155/2016/5690935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775768PMC
March 2016
7 Reads

Prooxidant-Antioxidant Balance in Patients with Systemic Lupus Erythematosus and Its Relationship with Clinical and Laboratory Findings.

Autoimmune Dis 2016 26;2016:4343514. Epub 2016 Jan 26.

Department of Internal Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran.

Aim. This study was aimed at evaluating prooxidant-antioxidant balance (PAB) in patients with systemic lupus erythematosus (SLE) and its relationship with laboratory findings and clinical manifestations. Methods. Read More

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http://downloads.hindawi.com/journals/ad/2016/4343514.pdf
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http://www.hindawi.com/journals/ad/2016/4343514/
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http://dx.doi.org/10.1155/2016/4343514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746302PMC
February 2016
17 Reads

Risk Factors and Adverse Events Poorly Predict Infections and Hypogammaglobulinemia in Granulomatosis with Polyangiitis Patients Receiving Rituximab.

Authors:
Emilio Besada

Autoimmune Dis 2016 18;2016:8095695. Epub 2016 Jan 18.

Bone and Joint Research Group, Institute of Clinical Medicine, UiT The Arctic University of Norway, 9037 Tromsø, Norway.

Background. 29 GPA patients from the Northern Norway vasculitis disease registry received rituximab (RTX) induction and maintenance. 24% and 31% had, respectively, severe and chronic infections while 45% had hypogammaglobulinemia and 28% discontinued RTX due to hypogammaglobulinemia. Read More

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http://dx.doi.org/10.1155/2016/8095695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739481PMC
February 2016
1 Read

Pentraxin 3 Plasma Levels and Disease Activity in Systemic Lupus Erythematosus.

Autoimmune Dis 2015 3;2015:354014. Epub 2015 Nov 3.

Clinical Investigation Laboratory, Diagnostics Department, Spedali Civili of Brescia, Brescia, Italy.

SLE is an autoimmune disorder that involves polyclonal autoimmunity against multiple autoantigens. PTX3, a marker of the acute-phase inflammatory response, plays an important role in innate immunity and in modulation of the adaptive immune response. Our study tried to resolve some rather controversial aspects of the use of PTX3 as a biomarker of disease activity in SLE patients. Read More

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http://dx.doi.org/10.1155/2015/354014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646995PMC
November 2015
17 Reads

The Attenuated Live Yellow Fever Virus 17D Infects the Thymus and Induces Thymic Transcriptional Modifications of Immunomodulatory Genes in C57BL/6 and BALB/C Mice.

Autoimmune Dis 2015 17;2015:503087. Epub 2015 Sep 17.

Division of Clinical Immunology, Department of Medicine, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes 3900, 14049-900 Ribeirão Preto, SP, Brazil.

Thymus is involved in induction of self-tolerance in T lymphocytes, particularly due to Aire activity. In peripheral tissues, Treg cells and immunomodulatory molecules, like the major histocompatibility complex (MHC) class Ib molecules, are essential for maintenance of autotolerance during immune responses. Viral infections can trigger autoimmunity and modify thymic function, and YFV17D immunization has been associated with the onset of autoimmunity, being contraindicated in patients with thymic disorders. Read More

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http://dx.doi.org/10.1155/2015/503087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589579PMC
October 2015
21 Reads

Immunological Parameters Associated With Vitiligo Treatments: A Literature Review Based on Clinical Studies.

Autoimmune Dis 2015 17;2015:196537. Epub 2015 Sep 17.

Faculdade de Ciências Humanas, Sociais e da Saúde, Universidade Fumec, 30310-190 Belo Horizonte, MG, Brazil ; Clínica de Dermatologia, Edificio Life Center, 30110-921 Belo Horizonte, MG, Brazil.

Vitiligo, a depigmentary disorder, caused by the loss of melanocytes, affects approximately 1% of the world population, irrespective of skin type, with a serious psychological impact on the patient quality of life. So far, the origin of vitiligo has not been traced and the pathogenesis is complex, involving the interplay of a multitude of variables. Although there is no treatment that ensures the complete cure of the disorder, there are some pharmacological, phototherapy, and surgical therapies available. Read More

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http://dx.doi.org/10.1155/2015/196537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589577PMC
October 2015
23 Reads

Association of IFN-γ : IL-10 Cytokine Ratio with Nonsegmental Vitiligo Pathogenesis.

Autoimmune Dis 2015 9;2015:423490. Epub 2015 Sep 9.

Department of Genetics, Osmania University, Hyderabad, Telangana 500007, India ; Department of Zoology, School of Sciences, Maulana Azad National Urdu University, Gachibowli, Hyderabad, Telangana 500032, India.

Background and Objectives. Cytokines regulate immune response and inflammation and play a crucial role in depigmentation process of vitiligo. The present study aimed to estimate the serum levels of pro- and anti-inflammatory cytokines, IFN-γ and IL-10, and their ratios in nonsegmental vitiligo patients and healthy individuals from India. Read More

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http://dx.doi.org/10.1155/2015/423490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579304PMC
October 2015
9 Reads
3 Citations

Social Support and Self-Reported Stress Levels in a Predominantly African American Sample of Women with Systemic Lupus Erythematosus.

Autoimmune Dis 2015 9;2015:401620. Epub 2015 Sep 9.

State University of New York at Buffalo, Buffalo, NY 14215, USA.

Lupus patients should avoid stress because physical or emotional stress can affect overall physical health. It has been suggested that social support has a positive influence on health status, but there is a lack of information in the literature on the association between the two among lupus patients. The current study investigated the association between social support and self-reported stress and coping status among African American women with lupus using data collected from two linked cross-sectional surveys. Read More

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http://dx.doi.org/10.1155/2015/401620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579303PMC
October 2015
7 Reads

Hepatic but Not CNS-Expressed Human C-Reactive Protein Inhibits Experimental Autoimmune Encephalomyelitis in Transgenic Mice.

Autoimmune Dis 2015 3;2015:640171. Epub 2015 Sep 3.

Department of Medicine, The University of Alabama Birmingham, Birmingham, AL 35294, USA.

We recently demonstrated that human C-reactive protein (CRP), expressed hepatically in transgenic mice (CRPtg), improved the outcome of experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS). The liver is the primary site of CRP synthesis in humans and in CRPtg mice but is also expressed by both at low levels in the CNS. To determine if CNS expression of human CRP is sufficient to impact EAE, we generated neuronal CRP transgenic mice (nCRPtg) wherein human CRP expression is driven by the neuron-specific Ca(2+)/calmodulin-dependent protein kinase IIα (CaMKIIα) gene promoter. Read More

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http://www.hindawi.com/journals/ad/2015/640171/
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http://dx.doi.org/10.1155/2015/640171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573232PMC
September 2015
6 Reads

Detection of Antibodies against Human and Plant Aquaporins in Patients with Multiple Sclerosis.

Autoimmune Dis 2015 26;2015:905208. Epub 2015 Jul 26.

Department of Preventive Medicine, Loma Linda University, 24785 Stewart Street, Loma Linda, CA 92354, USA ; Department of Clinical Sciences, Bastyr University California, 4106 Sorrento Valley Boulevard, San Diego, CA 92121, USA.

Multiple sclerosis (MS) is an autoimmune disease that affects the body's central nervous system. Around 90% of MS sufferers are diagnosed with relapsing-remitting MS (RRMS). We used ELISA to measure IgG, IgA, and IgM antibodies against linear epitopes of human and plant aquaporins (AQP4) as well as neural antigens in RRMS patients and controls to determine whether patients suffering from RRMS have simultaneous elevations in antibodies against these peptides and antigens. Read More

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http://dx.doi.org/10.1155/2015/905208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529886PMC
August 2015
19 Reads

Therapeutic Effect of Saponin Rich Fraction of Achyranthes aspera Linn. on Adjuvant-Induced Arthritis in Sprague-Dawley Rats.

Autoimmune Dis 2015 26;2015:943645. Epub 2015 Jul 26.

Department of Pharmaceutical Science and Technology, Institute of Chemical Technology, N. P. Marg, Matunga, Mumbai, Maharashtra 400 019, India.

Objective. Achyranthes aspera Linn. (AA) is used in folklore for the treatment of various inflammatory ailments and arthritis like conditions. Read More

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http://dx.doi.org/10.1155/2015/943645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529882PMC
August 2015
1 Citation

Urine Monocyte Chemoattractant Protein-1 and Lupus Nephritis Disease Activity: Preliminary Report of a Prospective Longitudinal Study.

Autoimmune Dis 2015 12;2015:962046. Epub 2015 Jul 12.

Nephrology Unit, Department of Medicine, Universiti Kebangsaan Malaysia Medical Centre, 56000 Kuala Lumpur, Malaysia.

Objective. This longitudinal study aimed to determine the urine monocyte chemoattractant protein-1 (uMCP-1) levels in patients with biopsy-proven lupus nephritis (LN) at various stages of renal disease activity and to compare them to current standard markers. Methods. Read More

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http://www.hindawi.com/journals/ad/2015/962046/
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http://dx.doi.org/10.1155/2015/962046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515289PMC
August 2015
5 Reads

Understanding and Managing Pregnancy in Patients with Lupus.

Autoimmune Dis 2015 12;2015:943490. Epub 2015 Jul 12.

Department of Rheumatology, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.

Systemic lupus erythematosus (SLE) is a chronic, multisystemic autoimmune disease that occurs predominantly in women of fertile age. The association of SLE and pregnancy, mainly with active disease and especially with nephritis, has poorer pregnancy outcomes, with increased frequency of preeclampsia, fetal loss, prematurity, growth restriction, and newborns small for gestational age. Therefore, SLE pregnancies are considered high risk condition, should be monitored frequently during pregnancy and delivery should occur in a controlled setting. Read More

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http://dx.doi.org/10.1155/2015/943490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515284PMC
August 2015
3 Reads

Association between Secondary and Primary Sjögren's Syndrome in a Large Collection of Lupus Families.

Autoimmune Dis 2015 12;2015:298506. Epub 2015 Jul 12.

Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA ; Arthritis & Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA ; Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK 73104, USA.

Objective. Systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS) share clinical and immunogenetic features and may occur together. We undertook this study to determine the risk of primary SS among SLE-unaffected relatives of SLE patients and whether or not primary and secondary SS tended to occur in the same families. Read More

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http://dx.doi.org/10.1155/2015/298506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515287PMC
August 2015
2 Reads
1 Citation

Predisposition to Cervical Atypia in Systemic Lupus Erythematosus: A Clinical and Cytopathological Study.

Autoimmune Dis 2015 9;2015:751853. Epub 2015 Jul 9.

Gynecology and Obstetrics Department, Faculty of Medicine, Cairo University, Cairo, Egypt.

Introduction. Systemic lupus erythematosus (SLE) is a complex disease with variable presentations, course, and prognosis. The female genital tract may be a potential target organ in SLE since cervical inflammation may be associated with disease activity. Read More

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http://www.hindawi.com/journals/ad/2015/751853/
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http://dx.doi.org/10.1155/2015/751853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512513PMC
August 2015
1 Read

Pathophysiological Relationship between Infections and Systemic Vasculitis.

Autoimmune Dis 2015 7;2015:286783. Epub 2015 Jul 7.

Internal Medicine Department, Fundación Valle del Lili, ICESI University, Cali, Colombia.

The development of autoimmune disorders requires a combination of genetic, immunological, and environmental factors. Infectious agents, such as viruses and bacteria, can trigger autoimmunity through different mechanisms, and for systemic vasculitis in particular, microbial agents have been suggested to be involved in its pathogenesis. Although the exact mechanisms have not been fully elucidated, different theories have been postulated. Read More

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http://dx.doi.org/10.1155/2015/286783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508375PMC

Gender and Ethnicity Based Differences in Clinical and Laboratory Features of Myasthenia Gravis.

Autoimmune Dis 2015 14;2015:197893. Epub 2015 Jun 14.

Neurology Department, Los Angeles Biomedical Research Institute, 1124 West Carson Street, Building E5, Torrance, CA 90502, USA ; Department of Neurology, Harbor-UCLA Medical Center, 1000 West Carson Street, Torrance, CA 90509, USA.

Background. Previous reports describe ethnicity based differences in clinical and laboratory features between Caucasians and African Americans with myasthenia gravis. However, it is not known whether these findings apply to other ethnicities. Read More

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http://dx.doi.org/10.1155/2015/197893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484557PMC
July 2015
6 Reads

Slipping through the Cracks: Linking Low Immune Function and Intestinal Bacterial Imbalance to the Etiology of Rheumatoid Arthritis.

Autoimmune Dis 2015 12;2015:636207. Epub 2015 Mar 12.

Asama Chemicals Co., Ltd., 20-3 Nihonbashi Kodenmacho, Chuo-ku, Tokyo 103, Japan.

Autoimmune diseases (ADs) are considered to be caused by the host immune system which attacks and destroys its own tissue by mistake. A widely accepted hypothesis to explain the pathogenic mechanism of ADs is "molecular mimicry," which states that antibodies against an infectious agent cross-react with a self-antigen sharing an identical or similar antigenic epitope. However, this hypothesis was most likely established based on misleading antibody assay data largely influenced by intense false positive reactions involved in immunoassay systems. Read More

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http://dx.doi.org/10.1155/2015/636207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377354PMC

Environmental triggers and autoimmunity.

Autoimmune Dis 2014 24;2014:798029. Epub 2014 Dec 24.

The Wellness Center, 23144 Emerson Way, Land O Lakes, FL 34639, USA.

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http://dx.doi.org/10.1155/2014/798029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4290643PMC
January 2015
5 Reads

Intravenous immunoglobulin treatment in chronic neurological diseases: do we have maintenance dose right?

Authors:
Ondrej Dolezal

Autoimmune Dis 2014 18;2014:962530. Epub 2014 Dec 18.

NHS Scotland, Dumfries and Galloway Royal Infirmary, Bankend Road, Dumfries DG14AP, UK.

Objectives. We tried to define, on individual basis, minimal effective maintenance dose of intravenous immunoglobulins (IVIG) in 26 patients with chronic neurological conditions requiring long-term IVIG treatment. Methods. Read More

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http://dx.doi.org/10.1155/2014/962530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281444PMC
January 2015
4 Reads

The prevalence of antinuclear antibodies in patients with sarcoidosis.

Autoimmune Dis 2014 17;2014:351852. Epub 2014 Dec 17.

Department of Orthopedics, Faculty of Medicine, Sifa University, Izmir, Turkey.

Introduction. Sarcoidosis, which is a chronic inflammatory granulomatous disease, can mimic different rheumatologic diseases including connective tissue diseases. Antinuclear antibodies are the markers used for connective tissue diseases. Read More

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http://dx.doi.org/10.1155/2014/351852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281448PMC
January 2015
76 Reads

Serum leptin levels in treatment-naive patients with clinically isolated syndrome or relapsing-remitting multiple sclerosis.

Autoimmune Dis 2014 19;2014:486282. Epub 2014 Nov 19.

Department of Neurology, Eginition Hospital, Athens University Medical School, 74 Vassilisis Sophias Avenue, 11528 Athens, Greece.

Several studies have investigated leptin levels in patients with multiple sclerosis (MS) with somewhat conflicting results. They have all focused on patients with established relapsing-remitting (RR) MS but have not specifically looked at patients with clinically isolated syndrome (CIS) suggestive of MS, in the early stages of disease. In this study, serum leptin levels were measured in 89 treatment-naïve patients with CIS (53 patients) or RRMS (36 patients) and 73 controls searching for differences between the groups and for associations with several disease parameters. Read More

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http://dx.doi.org/10.1155/2014/486282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254075PMC
December 2014

Occurrence of Autoimmune Diseases Related to the Vaccine against Yellow Fever.

Autoimmune Dis 2014 22;2014:473170. Epub 2014 Oct 22.

Faculdade de Medicina, Universidade de Brasília, Brasília, DF, Brazil.

Yellow fever is an infectious disease, endemic in South America and Africa. This is a potentially serious illness, with lethality between 5 and 40% of cases. The most effective preventive vaccine is constituted by the attenuated virus strain 17D, developed in 1937. Read More

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http://dx.doi.org/10.1155/2014/473170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227414PMC
November 2014
10 Reads

Neuroantibody biomarkers: links and challenges in environmental neurodegeneration and autoimmunity.

Autoimmune Dis 2014 23;2014:340875. Epub 2014 Jun 23.

Neurotoxicology Laboratory, Albany College of Pharmacy and Health Sciences, 106 New Scotland Avenue, Albany, NY 12208, USA.

The majority of neurodegenerative (ND) and autoimmune diseases (AID) remain idiopathic. The contribution of environmental chemicals to the development of these disorders has become of great interest in recent years. A convergence of mechanism between of ND and AID development has also emerged. Read More

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http://dx.doi.org/10.1155/2014/340875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090524PMC
July 2014
6 Reads

CD8+DR+ T-Cells and C3 Complement Serum Concentration as Potential Biomarkers in Thrombotic Antiphospholipid Syndrome.

Autoimmune Dis 2014 29;2014:868652. Epub 2014 May 29.

Clinical Immunology Department, Hospital General Universitario Gregorio Marañon, 28007 Madrid, Spain.

Purpose. To assess complement factors and T lymphocyte activation subset abnormalities in patients with thrombotic antiphospholipid syndrome (APS) as potential biomarkers for development of clinical complications. Methods. Read More

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http://dx.doi.org/10.1155/2014/868652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058841PMC
July 2014
2 Reads

Coeliac disease.

Autoimmune Dis 2014 28;2014:623784. Epub 2014 May 28.

Tampere Center for Child Health Research, University of Tampere and Tampere University Hospital, Finland.

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http://www.hindawi.com/journals/ad/2014/623784/
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http://dx.doi.org/10.1155/2014/623784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058525PMC
July 2014
7 Reads

Role of autoimmune responses in periodontal disease.

Autoimmune Dis 2014 25;2014:596824. Epub 2014 May 25.

M.R. Ambedkar Dental College and Hospital, No. 1/37, Cline Road, Cooke Town, Bangalore 560005, India.

Periodontal diseases are characterized by localized infections and inflammatory conditions that directly affect teeth supporting structures which are the major cause of tooth loss. Several studies have demonstrated the involvement of autoimmune responses in periodontal disease. Evidences of involvement of immunopathology have been reported in periodontal disease. Read More

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http://dx.doi.org/10.1155/2014/596824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055614PMC

Autoimmunity and the gut.

Autoimmune Dis 2014 13;2014:152428. Epub 2014 May 13.

The Wellness Center, 23144 Emerson Way, Land O Lakes, FL 34639, USA.

Autoimmune diseases have increased dramatically worldwide since World War II. This is coincidental with the increased production and use of chemicals both in industrial countries and agriculture, as well as the ease of travel from region to region and continent to continent, making the transfer of a pathogen or pathogens from one part of the world to another much easier than ever before. In this review, triggers of autoimmunity are examined, principally environmental. Read More

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http://dx.doi.org/10.1155/2014/152428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036413PMC
June 2014
1 Read

Autoimmunity and asbestos exposure.

Autoimmune Dis 2014 29;2014:782045. Epub 2014 Apr 29.

Center for Environmental Health Sciences, University of Montana, Missoula, MT 59812, USA.

Despite a body of evidence supporting an association between asbestos exposure and autoantibodies indicative of systemic autoimmunity, such as antinuclear antibodies (ANA), a strong epidemiological link has never been made to specific autoimmune diseases. This is in contrast with another silicate dust, crystalline silica, for which there is considerable evidence linking exposure to diseases such as systemic lupus erythematosus, systemic sclerosis, and rheumatoid arthritis. Instead, the asbestos literature is heavily focused on cancer, including mesothelioma and pulmonary carcinoma. Read More

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http://dx.doi.org/10.1155/2014/782045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022069PMC
June 2014
1 Read

Potential Sources and Roles of Adaptive Immunity in Age-Related Macular Degeneration: Shall We Rename AMD into Autoimmune Macular Disease?

Authors:
Serge Camelo

Autoimmune Dis 2014 30;2014:532487. Epub 2014 Apr 30.

Private Practice, 193 avenue du Président Wilson, La Plaine, 93210 Saint-Denis, France.

Age-related macular degeneration (AMD) is the leading cause of vision loss in the elderly throughout the industrialized world. Its most prominent pathologic features are lesions involving the retinal pigment epithelium (RPE) the Bruch's membrane, the degeneration of photoreceptors, and, in the most aggressive cases, choroidal neovascularization. Genetic associations between the risk of developing AMD and polymorphism within components of the complement system, as well as chemokine receptors expressed on microglial cells and macrophages, have linked retinal degeneration and choroidal neovascularization to innate immunity (inflammation). Read More

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http://dx.doi.org/10.1155/2014/532487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022009PMC
June 2014
8 Reads

Elements of the B cell signalosome are differentially affected by mercury intoxication.

Autoimmune Dis 2014 4;2014:239358. Epub 2014 May 4.

Department of Immunology and Microbiology, Wayne State University, Detroit, MI 48201, USA.

It has been suggested that environmental exposures to mercury contribute to autoimmune disease. Disruption of BCR signaling is associated with failure of central tolerance and autoimmunity, and we have previously shown that low levels of Hg(2+) interfere with BCR signaling. In this report we have employed multiparametric phosphoflow cytometry, as well as a novel generalization of the Overton algorithm from one- to two-dimensional unimodal distributions to simultaneously monitor the effect of low level Hg(2+) intoxication on activation of ERK and several upstream elements of the BCR signaling pathway in WEHI-231 B cells. Read More

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http://dx.doi.org/10.1155/2014/239358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024408PMC

Mercury, autoimmunity, and environmental factors on cheyenne river sioux tribal lands.

Autoimmune Dis 2014 24;2014:325461. Epub 2014 Apr 24.

College of Pharmacy, Community Environmental Health Program, University of New Mexico Health Sciences Center, 905 Vassar NE, Albuquerque, NM 87106, USA.

Mercury (Hg), shown to induce autoimmune disease in rodents, is a ubiquitous toxicant throughout Cheyenne River Sioux Tribe (CRST) lands. CRST members may be exposed to Hg through fish consumption (FC), an important component of native culture that may supplement household subsistence. Our goals were to ascertain whether total blood Hg levels (THg) reflect Hg exposure through FC and smoking, and determine whether THg is associated with the presence of anti-nuclear antibody (ANA) and specific autoantibodies (sAuAb). Read More

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http://dx.doi.org/10.1155/2014/325461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017878PMC
May 2014
11 Reads

Chronic exposure to oral pathogens and autoimmune reactivity in acute coronary atherothrombosis.

Autoimmune Dis 2014 25;2014:613157. Epub 2014 Feb 25.

Immunosciences Lab Inc, Los Angeles, CA 90035, USA.

Background. It has been hypothesized that various infective agents may activate immune reactions as part of the atherosclerotic process. We aimed to investigate the interrelationship between chronic exposure to oral pathogens and immune-inflammatory response in patients with acute coronary atherothrombosis. Read More

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http://www.hindawi.com/journals/ad/2014/613157/
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http://dx.doi.org/10.1155/2014/613157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003799PMC
May 2014
2 Reads

A tandem repeat in decay accelerating factor 1 is associated with severity of murine mercury-induced autoimmunity.

Autoimmune Dis 2014 10;2014:260613. Epub 2014 Apr 10.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.

Decay accelerating factor (DAF), a complement-regulatory protein, protects cells from bystander complement-mediated lysis and negatively regulates T cells. Reduced expression of DAF occurs in several systemic autoimmune diseases including systemic lupus erythematosus, and DAF deficiency exacerbates disease in several autoimmune models, including murine mercury-induced autoimmunity (mHgIA). Daf1, located within Hmr1, a chromosome 1 locus associated in DBA/2 mice with resistance to mHgIA, could be a candidate. Read More

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http://dx.doi.org/10.1155/2014/260613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003777PMC