1,085 results match your criteria Autoimmune Thyroid Disease and Pregnancy


Positive Impact of Levothyroxine Treatment on Pregnancy Outcome in Euthyroid Women with Thyroid Autoimmunity Affected by Recurrent Miscarriage.

J Clin Med 2021 May 13;10(10). Epub 2021 May 13.

Physiopathology of Reproduction and Andrology Unit, Department of Gender, Parenting, Child and Adolescent Medicine, Sandro Pertini Hospital, Via dei Monti Tiburtini 385/389, 00157 Rome, Italy.

Impaired thyroid hormone availability during early pregnancy is associated with recurrent miscarriage (RM) and adverse pregnancy outcomes. The main cause of thyroid dysfunction is thyroid-related autoimmunity (TAI), characterized by a significantly higher serum level of thyroid-stimulating hormone (TSH) compared to that of women without thyroid autoimmunity. TAI is associated with a significantly increased risk of miscarriage, and the incidence of TAI in women experiencing RM is higher compared to normal fertile women. Read More

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Management of Severe Graves' Hyperthyroidism in Pregnancy Following Immune Reconstitution Therapy in Multiple Sclerosis.

J Endocr Soc 2021 Jun 17;5(6):bvab044. Epub 2021 Mar 17.

Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Aker, Oslo, Norway.

Context: Alemtuzumab (ALZ), a CD52 monoclonal antibody, is highly efficacious in multiple sclerosis; however, side effects are common. Autoimmune thyroid disease (Graves' disease and Hashimoto thyroiditis) is a well-known complication of ALZ. Treatment of ALZ-induced Graves' disease can be challenging, and even more difficult during pregnancy. Read More

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The rationale for selenium supplementation in patients with autoimmune thyroiditis, according to the current state of knowledge.

Endokrynol Pol 2021 ;72(2):153-162

Department of Endocrinology, Metabolism, and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland.

Selenium (Se) supplements are commonly prescribed to autoimmune thyroiditis (AIT) patients by European endocrinologists, despite the lack of official guidelines. The majority of Europe is depleted of natural Se sources, and the daily population intake does not comply with recommended values. Optimal individual plasma Se concentration is reached when the selenoproteins (selenoprotein P, glutathione peroxidase) are fully saturated. Read More

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January 2021

"Small Thyroid Gland" in Reproductive Women without Autoimmune Thyroid Disease-Ultrasonographic Evaluation as a Useful Screening Tool for Hypothyroidism.

J Clin Med 2021 Apr 22;10(9). Epub 2021 Apr 22.

Department of Internal Medicine and Endocrinology, Medical University of Warsaw, Banacha 1a, 02-097 Warsaw, Poland.

Proper thyroid function is important for women of childbearing age, as hypothyroidism affects fertility, pregnancy and offspring. The upper reference limit for thyrotropin (TSH) in pregnancy was defined as <2.5 mU/L in the first trimester. Read More

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Glucocorticoid supplementation improves reproductive outcomes in infertile women with antithyroid autoimmunity undergoing ART: A meta-analysis.

Medicine (Baltimore) 2021 Apr;100(16):e25554

Reproductive Medical Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: Thyroid autoimmune disease (TAI) has been verified to be related to multiple adverse pregnancy outcomes. A growing number of evidences highlight the protective roles of glucocorticoid on the treatments of TAI. This meta-analysis aimed to study whether it is beneficial to add glucocorticoid treatment in infertile women with TAI when they are undergoing assisted reproductive technology (ART). Read More

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Subclinical thyroid diseases and isolated hypothyroxinemia during pregnancy.

Minerva Endocrinol (Torino) 2021 Apr 1. Epub 2021 Apr 1.

Unit of Endocrinology, Fondazione Policlinico Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.

Introducion: Thyroid diseases in pregnancy are common. While data on management of overt diseases are clear, there is no consensus regarding subclinical thyroid disease. Many studies have tried to clarify the impact of subclinical thyroid disease on pregnancy outcomes without reaching universal conclusions. Read More

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Factitious Disorder Masquerading as a Life-Threatening Anaphylaxis.

J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211006248

UPMC Pinnacle Hospital, Harrisburg, PA, USA.

Factitious disorder is a psychiatric disorder in which sufferers intentionally fabricate physical or psychological symptoms in order to assume the role of the patient, without any obvious gain. We present a case of a 23-year-old female with chronic urticaria who presented with dyspnea, dysphasia, mild generalized erythema, abdominal cramps, and headache. She was tachypneic and hypotensive. Read More

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A novel update on vitamin D in recurrent pregnancy loss (Review).

Mol Med Rep 2021 May 24;23(5). Epub 2021 Mar 24.

Department of Obstetrics, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.

Recurrent pregnancy loss (RPL) is usually characterized as ≥3 miscarriages before 20 weeks of gestation. Patients with RPL may have autoimmune abnormalities or alloimmune problems. Vitamin D has a major function on the mechanism of immunomodulation at the maternal‑fetal interface. Read More

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Evaluation of serum anti-Müllerian hormone levels in women with Hashimoto thyroiditis in the reproductive age

Turk J Med Sci 2021 04 30;51(2):716-721. Epub 2021 Apr 30.

Department of Endocrinology and Metabolism, Dışkapı Yıldırım Beyazıt Training and Research Hospital, University of Health Sciences, Ankara, Turkey

Background/aim: Autoimmune thyroid disease in women is associated with subfertility and early pregnancy loss, and patients with primary ovarian insufficiency have a high prevalence of thyroid autoimmune disorders. The aim of this study was to investigate the association between Hashimoto thyroiditis (HT) and ovarian reserve.

Materials And Methods: Levels of serum thyroid stimulating hormones, thyroid autoantibodies, and anti-Müllerian hormone (AMH) were measured in women with HT and a healthy control group between 2018 and 2019. Read More

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Variations in the Antithyroid Antibody Titre During Pregnancy and After Delivery.

Risk Manag Healthc Policy 2021 1;14:847-859. Epub 2021 Mar 1.

Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.

Background: Immunosuppression occurs during pregnancy, and the antithyroid antibody titre drops, rebounding after delivery. We aimed to determine variations in antithyroid antibody titres during pregnancy and after delivery.

Methods: This retrospective study was conducted in a single centre. Read More

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Impact of levothyroxine in women with positive thyroid antibodies on pregnancy outcomes: a systematic review and meta-analysis of randomised controlled trials.

BMJ Open 2021 02 23;11(2):e043751. Epub 2021 Feb 23.

Section of Endocrinology and Metabolism, Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

Objective: To evaluate the effect of levothyroxine therapy on pregnancy outcomes compared with placebo or no treatment in women without overt hypothyroidism with presence of thyroid peroxidase antibodies (TPOAb) and/or thyroglobulin antibodies (TgAb).

Design: Systematic review and meta-analysis of randomised controlled trials STUDY ELIGIBILITY CRITERIA: Prespecified criteria for inclusion were: randomised trials of levothyroxine versus control (placebo or no treatment) among women with positive TPOAb or TgAb who were pregnant or considering conception.

Data Sources: Ovid MEDLINE, EMBASE, CINAHL, Cochrane Database of Systematic Reviews and Cochrane Central Register of Controlled Trials were searched from 1980 to 5 November 2020. Read More

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February 2021

Diagnosis and Treatment of Multiple Sclerosis: A Review.

JAMA 2021 02;325(8):765-779

Cleveland Clinic Mellen Center, Cleveland, Ohio.

Importance: Multiple sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system characterized by inflammatory demyelination with axonal transection. MS affects an estimated 900 000 people in the US. MS typically presents in young adults (mean age of onset, 20-30 years) and can lead to physical disability, cognitive impairment, and decreased quality of life. Read More

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February 2021

The relationship between Thyroid dysfunction during pregnancy and Gestational diabetes mellitus.

Endokrynol Pol 2021 Feb 23. Epub 2021 Feb 23.

Department of Internal Medicine, Medical University -Sofia, Sofia, Bulgaria;Clinic of Endocrinology, University Hospital "Alexanrdovska", 1" St. George Sofiyski" st, 1000 Sofia, Bulgaria.

Background: Thyroid dysfunction and gestational diabetes are the two most common endocrine disorders that can be observed during pregnancy. Thyroid function abnormalities could be associated with insulin resistance (IR) and changes in carbohydrate metabolism. In patients with type 1 diabetes, thyroid function is usually evaluated to rule out abnormalities within a second autoimmune disease. Read More

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February 2021

Exposure to Bisphenol A Analogs and the Thyroid Function and Volume in Women of Reproductive Age-Cross-Sectional Study.

Front Endocrinol (Lausanne) 2020 19;11:587252. Epub 2021 Jan 19.

Department of Internal Medicine and Endocrinology, Medical University of Warsaw, Warsaw, Poland.

Bisphenols (BPs) are commonly known plastifiers that are widely used in industry. The knowledge about the impact of BPs on thyroid function is scarce. Proper thyroid functioning is especially important for women of reproductive age, as hypothyroidism affects fertility, pregnancy outcomes and the offspring. Read More

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Prevalence and course of thyroid dysfunction in neonates at high risk of Graves' disease or with non-autoimmune hyperthyroidism.

Eur J Endocrinol 2021 Mar;184(3):427-436

Assistance Publique-Hôpitaux de Paris, Robert Debré University Hospital, Endocrinology-Diabetology Department, Reference Center for Growth and Development Endocrine Diseases, Paris, France.

Objective: Neonatal hyperthyroidism may be caused by a permanent non-autoimmune genetic disorder or, more frequently, by maternally transmitted high serum TRAb levels. Variable thyroid dysfunction may be observed in this second context. We aimed to evaluate the prevalence of neonatal non-autoimmune hyperthyroidism and of the different types of thyroid function in neonates with a high risk of hyperthyroidism due to maternal Graves' disease (GD). Read More

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MANAGEMENT OF ENDOCRINE DISEASE: Thyroid and female infertility: more questions than answers?!

Authors:
Kris Poppe

Eur J Endocrinol 2021 Apr;184(4):R123-R135

Endocrine Unit, CHU Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium.

Severe thyroid dysfunction may lead to menstrual disorders and infertility via direct and indirect interactions with the hypothalamo-pituitary-ovarian axis and the reproductive organs. However, the exact prevalence of infertility in women with thyroid disorders remains unknown. Fertility problems may persist even after restoring normal thyroid function, and then surgery and/or an assisted reproductive technology (ART) may be necessary to obtain a pregnancy. Read More

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Recent insights into the impact of immune dysfunction on reproduction in autoimmune thyroiditis.

Clin Immunol 2021 03 2;224:108663. Epub 2021 Jan 2.

Institute of Reproductive Health, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China. Electronic address:

Autoimmune thyroiditis (AIT) is a common organ-specific autoimmune disease with a high incidence among women of childbearing age. Recent studies have reported that women with AIT are more susceptible to infertility, miscarriage and preterm birth. It has been investigated that abnormal changes in maternal immune system and maternal-fetal interface can dampen the immune tolerance between mother and fetus, which underlie the pathogenesis of adverse pregnancy outcomes. Read More

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Anaesthesia for ophthalmic procedures in patients with thyroid eye disease.

Anaesth Intensive Care 2020 Nov 16;48(6):430-438. Epub 2020 Nov 16.

Department of Ophthalmology, Royal Prince Alfred Hospital, Camperdown, Australia.

Thyroid eye disease is an autoimmune inflammatory disorder of the orbit in adults. It causes inflammation, expansion and fibrosis of orbital fat, muscles and the lacrimal gland, leading to facial disfigurement, functional disability and, in severe cases, blindness. Overall, approximately 20% of affected patients need some form of surgical intervention requiring anaesthesia. Read More

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November 2020

Explore comorbidities associated with systemic lupus erythematosus-A total population-based case-control study.

QJM 2020 Nov 9. Epub 2020 Nov 9.

Department of Health Promotion and Health Education, National Taiwan Normal University, Taipei, Taiwan.

Background: Because of the increasing incidence and overall burden of systemic lupus erythematosus (SLE), efforts have been made to identify the factors that contribute to SLE onset and progression.

Aim: We conducted a total population-based case-control study to explore the prior comorbidities associated with SLE.

Design And Methods: Data were collected from Taiwan's National Health Insurance Research Database. Read More

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November 2020

The Clinical Value and Variation of Antithyroid Antibodies during Pregnancy.

Dis Markers 2020 21;2020:8871951. Epub 2020 Oct 21.

Laboratory for Reproductive Immunology, Hospital and Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University, Shanghai, China.

Antithyroid antibodies, which include thyroid-stimulating hormone receptor antibodies (TRAbs), thyroid peroxidase antibodies (TPOAbs), and thyroid globulin antibodies (TgAbs), are widely known for their tight association with thyroid autoimmune diseases. The variation in all three kinds of antibodies also showed different trends during and after pregnancy (Weetman, 2010). This article reviewed the the physiological changes, while focusing on the variation of thyroid antibodies concentration in women during and after pregnancy, and adverse consequences related to their elevation. Read More

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October 2020

Thyroid disorders in subfertility and early pregnancy.

Ther Adv Endocrinol Metab 2020 13;11:2042018820945855. Epub 2020 Oct 13.

Department of Endocrinology, Guy's & St. Thomas' NHS Foundation Trust, DEDC 3rd Floor Lambeth Wing, St. Thomas' Hospital, London, SE1 7EH, UK.

Disorders of thyroid function are common in pregnancy and have implications for foetal and maternal health. Thyroid autoimmunity, as evidenced by the presence of elevated levels of anti-thyroid antibodies (anti-TPO and anti-Tg antibodies) is associated with an increased risk of miscarriage, though the mechanism remains poorly understood. There has been considerable focus on the implications and optimal management of pregnant women with thyroid disease, especially those undergoing assisted reproduction. Read More

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October 2020

Antithyroid antibodies may predict serum beta HCG levels and biochemical pregnancy losses in euthyroid women with IVF single embryo transfer.

Gynecol Endocrinol 2020 Oct 13:1-4. Epub 2020 Oct 13.

Department of Reproductive Endocrinology and IVF Unit, Bahcesehir University Medical Park Goztepe Hospital, Istanbul, Turkey.

Objective: To investigate the relationship between thyroid autoimmunity and early pregnancy serum β-HCG levels in intracytoplasmic sperm injection patients.

Methods: The study subjects were 85 female euthyroid patients undergoing intracytoplasmic sperm injection embryo transfer cycles with GnRH antagonist treatment. Patients who received transfer of more than one embryo, those with serum TSH levels of greater than 2. Read More

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October 2020

8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) as a Cause of Autoimmune Thyroid Diseases (AITD) During Pregnancy?

Yale J Biol Med 2020 09 30;93(4):501-515. Epub 2020 Sep 30.

DNA Damage Laboratory of Food Science Department, Faculty of Pharmacy, Medical University of Lodz, Lodz, Poland.

The thyroid is not necessary to sustain life. However, thyroid hormones (TH) strongly affect the human body. Functioning of the thyroid gland affects the reproductive capabilities of women and men, as well as fertilization and maintaining a pregnancy. Read More

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September 2020

Thyroid peroxidase in human endometrium and placenta: a potential target for anti-TPO antibodies.

Clin Exp Med 2021 Feb 26;21(1):79-88. Epub 2020 Sep 26.

Reproductive Immunology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.

Autoimmune thyroid disease is the most common endocrine disorder during pregnancy. Thyroid autoantibodies (TAs) have been suggested to serve a role in implantation failure and spontaneous abortion. Until now, there are no data on the potential interaction of TAs with human reproductive organs. Read More

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February 2021

Lithium Use During Pregnancy in a Patient With Bipolar Disorder and Multiple Sclerosis.

Clin Neuropharmacol 2020 Sep/Oct;43(5):158-161

Dipartimento di Medicina Clinica e Sperimentale, Università di Pisa, Pisa, Italy.

Although lithium is widely used as a first-line treatment for mood disorders, its mood-stabilizing effects remain not fully understood. A growing body of data are stressing that lithium seems to show broader properties, including neuroprotective effects. Lithium's ability to inhibit glycogen synthase kinase 3β, an enzyme that participates in the phosphorylation of τ, a microtubule-associated protein, stimulated interest in its possible therapeutic role in Alzheimer disease and other neurodegenerative disorders. Read More

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September 2020

Management of Graves Thyroidal and Extrathyroidal Disease: An Update.

Authors:
George J Kahaly

J Clin Endocrinol Metab 2020 12;105(12)

Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany.

Context: Invited update on the management of systemic autoimmune Graves disease (GD) and associated Graves orbitopathy (GO).

Evidence Acquisition: Guidelines, pertinent original articles, systemic reviews, and meta-analyses.

Evidence Synthesis: Thyrotropin receptor antibodies (TSH-R-Abs), foremost the stimulatory TSH-R-Abs, are a specific biomarker for GD. Read More

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December 2020

Effect of levothyroxine on pregnancy outcomes in women with thyroid autoimmunity: a systematic review with meta-analysis of randomized controlled trials.

Fertil Steril 2020 12 8;114(6):1306-1314. Epub 2020 Sep 8.

Department of Surgery, Zucker School of Medicine at Hofstra/Northwell, New York, New York.

Objective: To investigate whether levothyroxine is associated with improved live birth and other benefits in women with thyroid autoimmunity.

Design: Systematic review and meta-analysis.

Setting: Not applicable. Read More

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December 2020

The pathogenic role of circulating Hashimoto's Thyroiditis-derived TPO-positive IgG on fetal loss in naïve mice.

Am J Reprod Immunol 2021 01 20;85(1):e13331. Epub 2020 Sep 20.

Laboratory of the Mosaic of Autoimmunity, Saint Petersburg State University, Saint Petersburg, Russia.

Problem: Antibody-mediated autoimmune diseases, such as autoimmune thyroid diseases (ATD), systemic lupus erythematosus (SLE), and antiphospholipid syndrome (APS), often are associated with recurrent fetal loss. One of the ATD is Hashimoto's thyroiditis which recently showed association with complications of pregnancy with increased levels of circulating autoantibodies reactive with epitopes on thyroid tissue such as thyroid peroxidase (anti-TPO). In retrospective study of sera analyses in patients with Hashimoto's thyroiditis, all patients had mainly elevated circulating anti-TPO autoantibodies. Read More

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January 2021

Prognosis of autoimmune thyroid disease associated with hereditary thrombophilia during pregnancy.

Exp Ther Med 2020 Sep 22;20(3):2429-2433. Epub 2020 May 22.

Department of Obstetrics Gynecology, 'Carol Davila' University of Medicine and Pharmacy, University Emergency Hospital Bucharest, 050098 Bucharest, Romania.

Autoimmune thyroid pathology has been connected with several systemic autoimmune disorders, namely hereditary thrombophilia and antiphospholipid syndrome. In an iodine-replete country, these diseases need to be evaluated simultaneously. This study was conducted to assess the connection between acute and chronic thyroiditis and inherited thrombophilia and their potential implications in pregnancy. Read More

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September 2020

Autoimmune Polyglandular Syndrome Type 2 and Pregnancy.

Folia Med (Plovdiv) 2020 Jun;62(2):408-411

Dr Shterev Hospital, Sofia, Bulgaria.

Autoimmune polyglandular syndromes are combinations of various endocrine and nonendocrine autoimmune diseases, as well as the presence of elevated organ-specific antibody titers. We present a clinical case of a 41-year-old pregnant patient with type 2 autoimmune polyglandular syndrome, combining Addison's disease, Hashimoto's thyroiditis and hypogonadism. The pregnancy was achieved after the use of assisted reproductive technology. Read More

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