1,046 results match your criteria Autoimmune Thyroid Disease and Pregnancy


Thyroid dysfunction following pregnancy and implications for breastfeeding.

Best Pract Res Clin Endocrinol Metab 2020 Jun 20:101438. Epub 2020 Jun 20.

Division of Maternal Medicine, Center for Maternal-Fetal-Neonatal and Reproductive Medicine, National Center for Child Health and Development, 2-10-1 Okura, Setagayaku, Tokyo, 1578535, Japan. Electronic address:

Subclinical autoimmune thyroiditis exacerbates after delivery through immune rebound mechanisms and results in 5 types of thyroid dysfunction. The prevalence of postpartum thyroid dysfunction is around 5% in mothers in the general population. Typically, an exacerbation induces destructive thyrotoxicosis followed by transient hypothyroidism, known as postpartum thyroiditis. Read More

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http://dx.doi.org/10.1016/j.beem.2020.101438DOI Listing

Management of neonates born to mothers with thyroid dysfunction, and points for attention during pregnancy.

Best Pract Res Clin Endocrinol Metab 2020 Jun 18:101437. Epub 2020 Jun 18.

Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Pediatric Endocrinology, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands. Electronic address:

Thyroid hormone (TH) is indispensable for normal embryonic and fetal development. Throughout gestation TH is provided by the mother via the placenta, later in pregnancy the fetal thyroid gland makes an increasing contribution. Maternal thyroid dysfunction, resulting in lower or higher than normal (maternal) TH levels and transfer to the embryo/fetus, can disturb normal early development. Read More

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http://dx.doi.org/10.1016/j.beem.2020.101437DOI Listing

Graves' disease.

Nat Rev Dis Primers 2020 Jul 2;6(1):52. Epub 2020 Jul 2.

Department of Medicine I, Johannes Gutenberg University Medical Centre, Mainz, Germany.

Graves' disease (GD) is an autoimmune disease that primarily affects the thyroid gland. It is the most common cause of hyperthyroidism and occurs at all ages but especially in women of reproductive age. Graves' hyperthyroidism is caused by autoantibodies to the thyroid-stimulating hormone receptor (TSHR) that act as agonists and induce excessive thyroid hormone secretion, releasing the thyroid gland from pituitary control. Read More

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http://dx.doi.org/10.1038/s41572-020-0184-yDOI Listing

Alemtuzumab-related thyroid disease in people with multiple sclerosis is associated with age and brainstem phenotype at disease onset.

Mult Scler J Exp Transl Clin 2020 Apr-Jun;6(2):2055217320933928. Epub 2020 Jun 18.

Department of Neurology, St. Vincent's University Hospital, Dublin, Ireland.

Background: Autoimmune thyroid disease (AITD) occurs in 40%-50% of alemtuzumab-treated persons with multiple sclerosis (pwMS), most of whom will develop Graves' Disease (GD).

Objective: To explore contributory factors for alemtuzumab-related AITD in pwMS.

Methods: A retrospective patient chart review was performed. Read More

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http://dx.doi.org/10.1177/2055217320933928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307483PMC

Pregnancy outcomes and postpartum relapse rates in women with RRMS treated with alemtuzumab in the phase 2 and 3 clinical development program over 16 years.

Mult Scler Relat Disord 2020 May 6;43:102146. Epub 2020 May 6.

University of Cambridge, Cambridge, United Kingdom. Electronic address:

Background: Relapsing-remitting multiple sclerosis (RRMS) is frequently diagnosed in women of reproductive age. Because the use of disease-modifying therapies (DMTs) early in the disease course is increasing, it is important to evaluate the safety of DMTs in pregnant women and their developing fetuses. Alemtuzumab, approved for the treatment of relapsing forms of MS, is administered as 2 courses of 12 mg/day on 5 consecutive days at baseline and on 3 consecutive days 12 months later. Read More

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http://dx.doi.org/10.1016/j.msard.2020.102146DOI Listing

ENDOCRINOLOGY IN THE TIME OF COVID-19: Management of hyperthyroidism and hypothyroidism.

Eur J Endocrinol 2020 Jul;183(1):G33-G39

Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.

This manuscript provides guidance on the management of thyroid dysfunction during the COVID-19 pandemic. Autoimmune thyroid diseases are not linked to increased risks of COVID-19. Uncontrolled thyrotoxicosis may result in more severe complications from SARS-CoV-2 infection, including thyroid storm. Read More

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http://dx.doi.org/10.1530/EJE-20-0445DOI Listing

Targeted Antenatal Screening for Predicting Postpartum Thyroiditis and Its Evolution Into Permanent Hypothyroidism.

Front Endocrinol (Lausanne) 2020 17;11:220. Epub 2020 Apr 17.

Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.

Postpartum thyroiditis (PPT) has a prevalence of 1-22%, with an ~50% rate of evolution into permanent hypothyroidism (PH). PPT risk is assessed by measuring serum thyroid antibodies during gestation, as 1/3-1/2 of Ab+ve pregnant women will develop PPT. Family and personal history positive for autoimmune non-thyroid diseases (AINTDT), and consumption of swordfish increases while consumption of small oily fish decreases the risk of PPT. Read More

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http://dx.doi.org/10.3389/fendo.2020.00220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180182PMC

Analysis of Blimp-1 and PD-1/PD-L1 Immune Checkpoint in an Autoimmune Thyroiditis Animal Model.

Int J Endocrinol 2020 17;2020:6543593. Epub 2020 Feb 17.

Department of Endocrinology and Metabolism, The Second Hospital of Dalian Medical University, Dalian, China.

Objective: B lymphocyte-induced maturation protein 1 (Blimp-1) and programmed cell death protein 1 (PD-1) have opposing roles in the development of T cells; however, the mechanism of autoimmune thyroiditis- (AIT-) associated abortion is unclear. The present study investigated the expression of Blimp-1 and PD-1/PD-ligand 1 (PD-L1) in AIT-associated pregnancy loss and elucidated the related signaling pathway involving in the inflammatory response.

Methods: An experimental fetal loss model with autoimmune thyroiditis was established after murine thyroglobulin- (mTg-) immunized CBA/J female mice mating with Balb/c males. Read More

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http://dx.doi.org/10.1155/2020/6543593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178515PMC
February 2020

Pregnancy-related reference intervals for serum thyrotropin based on real-life clinical data.

Gynecol Endocrinol 2020 Apr 23:1-4. Epub 2020 Apr 23.

Laboratorio analisi chimico-cliniche e di endocrinologia, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.

During pregnancy, thyroid homeostasis is physiologically modified, leading to altered levels of thyrotropin (TSH): hence, the adoption of pregnancy-related, population- and method-specific reference ranges is recommended. This monocentric and retrospective study was conducted to establish local pregnancy-related reference intervals for serum TSH in singleton pregnant women using real-life clinical data. We included women who measured serum TSH during pregnancy at our Laboratory over six years, excluding pregnant women with current or past history of thyroid disease, pituitary or autoimmune diseases, use of medications known to influence thyroid function, multiple and/or pathological pregnancies, BMI >30 Kg/m. Read More

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http://dx.doi.org/10.1080/09513590.2020.1756251DOI Listing

Postpartum Thyroiditis in Women With Euthyroid and Hypothyroid Hashimoto's Thyroiditis Antedating Pregnancy.

J Clin Endocrinol Metab 2020 Jul;105(7)

Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.

Context: Postpartum thyroiditis (PPT) is defined as the occurrence of de novo autoimmune thyroid disease accompanied by thyroid dysfunction in the first year postpartum. However, hormonal changes resembling the typical pattern of PPT have been reported to occur even in women with pregestational Hashimoto's thyroiditis (HT) on levothyroxine (LT4).

Objective: To evaluate the risk of PPT in women with HT antedating pregnancy. Read More

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http://dx.doi.org/10.1210/clinem/dgaa197DOI Listing

Graves Disease With Thyroid-Stimulating Hormone Receptor-Blocking Autoantibodies During Pregnancy.

Ann Intern Med 2020 Jun 24;172(11):767-769. Epub 2020 Mar 24.

Johannes Gutenberg University Medical Center, Mainz, Germany (G.J.K.).

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http://dx.doi.org/10.7326/L19-0818DOI Listing

[Pathogenetic features of immunological disorders in women with thyroid peroxidase antibodies presence and their effect on infertility treatment by in vitro fertilization (IVF)].

Probl Endokrinol (Mosk) 2019 12 25;65(4):289-294. Epub 2019 Dec 25.

Endocrinology Research Centre.

Autoimmune thyroiditis (AIT) is the most common thyroid disease among women of fertile age. An increase of thyropercosidase antibodies (TPO-Ab) occupies one of the leading positions among other autoantibodies in patients with idiopathic infertility. Stimulation of superovulation in assisted reproductive technology (ART) programs leads to thyroid overstimulation, relative hypothyroxinemia and an increase of thyroid stimulating hormone (TSH) level in women with positive TPO-Ab carrier state, leading to a decrease in the reserve capacity of the thyroid affected by the autoimmune process. Read More

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http://dx.doi.org/10.14341/probl10298DOI Listing
December 2019

Management of thyrotoxicosis during pregnancy.

Best Pract Res Clin Endocrinol Metab 2020 Mar 5:101414. Epub 2020 Mar 5.

Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.

Thyrotoxicosis during pregnancy should be adequately managed and controlled to prevent maternal and fetal complications. The evaluation of thyroid function in pregnant women is challenged by the physiological adaptations associated with pregnancy, and the treatment with antithyroid drugs (ATD) raises concerns for the pregnant woman and the fetus. Thyrotoxicosis in pregnant women is mainly of autoimmune origin, and the measurement of thyroid stimulating hormone-receptor antibodies (TRAb) plays a key role. Read More

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http://dx.doi.org/10.1016/j.beem.2020.101414DOI Listing

Effect of Thyroxine Therapy on Depressive Symptoms Among Women With Subclinical Hypothyroidism.

Obstet Gynecol 2020 Apr;135(4):812-820

Departments of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas, University of Texas - Southwestern, Dallas, Texas, Northwestern University, Chicago, Illinois, University of Utah Health Sciences Center, Salt Lake City, Utah, Wayne State University, Detroit, Michigan, Columbia University, New York, New York, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, University of Alabama at Birmingham, Birmingham, Alabama; Brown University, Providence, Rhode Island, University of Texas - Houston, Houston, Texas, The Ohio State University, Columbus, Ohio, Case Western Reserve University, Cleveland, Ohio, Oregon Health Sciences University, Portland, Oregon, University of Pittsburgh, Pittsburgh, Pennsylvania, Medical University of South Carolina, Charleston, South Carolina; and the George Washington University Biostatistics Center, Washington, DC; and the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland.

Objective: To estimate the effect of antenatal treatment of subclinical hypothyroidism on maternal depressive symptoms.

Methods: We conducted an ancillary study to a multicenter trial in women with singleton pregnancies diagnosed with subclinical hypothyroidism randomized to antenatal thyroxine therapy or placebo. Treatment was discontinued at the end of pregnancy. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103482PMC
April 2020
5.175 Impact Factor

Parity and Incidence of Thyroid Autoimmunity: A Population-Based Tehran Thyroid Study.

Thyroid 2020 May 7. Epub 2020 May 7.

Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Autoimmune thyroid disease is the most common autoimmune disorder. Evidence regarding causes of the high prevalence and incidence of thyroid autoimmunity in women, and especially women of reproductive age, is still inconclusive and previous studies have suggested genetic, environmental, and existential factors to play a role in its pathogenesis. In this study, we aimed to investigate the effect of parity and other reproductive factors on the incidence of thyroid autoimmunity within the framework of the Tehran Thyroid Study (TTS). Read More

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http://dx.doi.org/10.1089/thy.2019.0440DOI Listing
May 2020
4.493 Impact Factor

Thyroid Disease in Lupus: An Updated Review.

ACR Open Rheumatol 2020 Feb 6;2(2):74-78. Epub 2020 Jan 6.

Case Western Reserve University at MetroHealth Medical Center, Cleveland, Ohio.

In the following review, we seek to provide an overview of the current understanding of various thyroid manifestations affecting patients with systemic lupus erythematosus (SLE), including topics ranging from thyroid-related complications to SLE in pregnancy. Autoimmune diseases tend to coincide, and an association between thyroid disease and SLE has been reported for more than 50 years. There is no evidence that the coexistence of thyroid disease and lupus alters the disease course or manifestations of either. Read More

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http://dx.doi.org/10.1002/acr2.11105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011406PMC
February 2020

TSH RECEPTOR ANTIBODIES: RELEVANCE & UTILITY.

Endocr Pract 2020 Jan;26(1):97-106

Antibodies (Abs) to the thyrotropin (TSH) receptor (TSH-R) play an important role in the pathogenesis of autoimmune thyroid disease (AITD). We define the complex terminology that has arisen to describe TSH-R-Abs, review the mechanisms of action of the various types of TSH-R-Abs, and discuss significant advances that have been made in the development of clinically useful TSH-RAb assays. Literature review and discussion. Read More

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http://dx.doi.org/10.4158/EP-2019-0363DOI Listing
January 2020

Autoimmunity and the endocrine system: Thyroid, hypophysis and pregnancy.

Best Pract Res Clin Endocrinol Metab 2019 12 9;33(6):101374. Epub 2020 Jan 9.

Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Russia. Electronic address:

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http://dx.doi.org/10.1016/j.beem.2020.101374DOI Listing
December 2019

Impact of Thyroid Autoimmunity on Ovarian Reserve, Pregnancy Outcomes, and Offspring Health in Euthyroid Women Following Fertilization/Intracytoplasmic Sperm Injection.

Thyroid 2020 Apr 11;30(4):588-597. Epub 2020 Feb 11.

Center for Reproductive Medicine, Shandong University, Jinan, China.

Thyroid autoimmunity (TAI) is the most frequent autoimmune disease among reproductive-aged women. It has been related to premature ovarian insufficiency, but the mechanisms remain elusive, and its association with ovarian reserve in euthyroid women is debatable. Moreover, the impact of TAI on assisted reproduction is controversial: especially for women with diminished ovarian reserve (DOR), few studies are available. Read More

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http://dx.doi.org/10.1089/thy.2018.0657DOI Listing

Graves' Disease and the Post-partum Period: An Intriguing Relationship.

Front Endocrinol (Lausanne) 2019 10;10:853. Epub 2019 Dec 10.

Unit of Internal Medicine and Endocrinology, Laboratory for Endocrine Disruptors, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy.

The post-partum period is an immunologically peculiar period in a woman's life. Indeed, most of the pregnancy-related immune changes gradually revert in the 12 months following delivery. Although the post-partum period has long been identified as a period of aggravation of autoimmune thyroid diseases, most of the currently available studies took into account the relationship between post-partum and autoimmune thyroiditis. Read More

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http://dx.doi.org/10.3389/fendo.2019.00853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914725PMC
December 2019

Recurrent Pregnancy Loss in Women with Hashimoto's Thyroiditis with Concurrent Non-Endocrine Autoimmune Disorders.

Thyroid 2020 Mar 3;30(3):457-462. Epub 2020 Feb 3.

Department of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Latina, Italy.

An increased rate of recurrent miscarriage has been described in patients with autoimmune thyroid disease. However, there is a lack of studies that assess the rate of recurrent pregnancy loss (RPL) in patients with Hashimoto's thyroiditis (HT) isolated or with concurrent non-endocrine autoimmune disorders (NEAD). The objective of the study was to assess the rate of RPL in patients with HT isolated or accompanied with non-endocrine autoimmune diseases. Read More

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http://dx.doi.org/10.1089/thy.2019.0456DOI Listing

The characteristics of patients with possible familial hypercholesterolemia-screening a large payer/provider healthcare delivery system.

QJM 2020 Jun;113(6):411-417

Clalit Research Institute.

Background: Familial hypercholesterolemia (FH) is an under-diagnosed condition.

Aim: We applied standard laboratory criteria across a large longitudinal electronic medical record database to describe cross-sectional population with possible FH.

Methods: A cross-sectional study of Clalit Health Services members. Read More

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http://dx.doi.org/10.1093/qjmed/hcz327DOI Listing

Infertility in women with systemic autoimmune diseases.

Best Pract Res Clin Endocrinol Metab 2019 12 2;33(6):101369. Epub 2019 Dec 2.

Department of Obstetrics and Gynecology of I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.

Infertility consists by definition in" failure to achieve a clinical pregnancy after 12 months or more of regular unprotected intercourse" while the term subfertility means a delay to achieve pregnancy. Several factors can contribute to infertility or subfertility in patients with systemic autoimmune diseases. The association of systemic autoimmune conditions with endometriosis, celiac disease and thyroid autoimmunity that are well known causes of infertility and/or subfertility need to be taken in consideration when difficulties in the onset of pregnancy is reported. Read More

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http://dx.doi.org/10.1016/j.beem.2019.101369DOI Listing
December 2019

Hypothyroidism and isolated hypothyroxinemia in pregnancy, from physiology to the clinic.

Taiwan J Obstet Gynecol 2019 Nov;58(6):757-763

Unidad de Investigación Médica en Medicina Reproductiva, Unidad Médica de Alta Especialidad, Hospital de Gineco Obstetricia No. 4, Luis Castelazo Ayala, Instituto Mexicano del Seguro Social, Río Magdalena 289, 6° Piso, Laboratorio K, Colonia Tizapan San Ángel, Alcaldía Álvaro Obregón, C.P. 01090, Ciudad de México, Mexico.

Many changes occur in the physiology of the maternal thyroid gland to maintain an adequate level of thyroid hormones (THs) at each stage of gestation during normal pregnancy, however, some factors can produce low levels of these hormones, which can alter the onset and progression of pregnancy. Deficiency of THs can be moderate or severe, and classified as overt or clinical hypothyroidism, subclinical hypothyroidism, and isolated hypothyroxinemia. Overt hypothyroidism has been reported in 0. Read More

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http://dx.doi.org/10.1016/j.tjog.2019.09.005DOI Listing
November 2019

Reduced expression of PD-L1 in autoimmune thyroiditis attenuate trophoblast invasion through ERK/MMP pathway.

Reprod Biol Endocrinol 2019 Oct 27;17(1):86. Epub 2019 Oct 27.

Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Dalian Medical University, 467 Zhongshan Road, Dalian, 116027, Liaoning, China.

Background: Autoimmune thyroiditis (AIT) with euthyroid is associated with miscarriage. But the exact mechanism remains unclear. Studies have shown that the programmed cell death-1 (PD-1)/programmed cell death -ligand 1 (PD-L1) pathway is essential for normal pregnancy. Read More

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http://dx.doi.org/10.1186/s12958-019-0536-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816196PMC
October 2019

Medullary thyroid carcinoma with double negative calcitonin and CEA: a case report and update of literature review.

BMC Endocr Disord 2019 Oct 16;19(1):103. Epub 2019 Oct 16.

Division of Thyroid Surgery - Department of Medical and Advanced Surgical Sciences, University of Campania "Luigi Vanvitelli", School of Medicine, Via Sergio Pansini, 5, 80131, Naples, Italy.

Background: Medullary thyroid carcinoma is a malignant uncommon and aggressive tumour of the parafollicular C cells. In about 75% of cases it is sporadic while, in case of RET mutation, it is associated to multiple endocrine neoplasia type 2 (25% of cases). The biochemical features of medullary thyroid carcinoma include the production of calcitonin and carcinoembryogenic antigen. Read More

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http://dx.doi.org/10.1186/s12902-019-0435-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794852PMC
October 2019
1 Read

2019 European Thyroid Association Guidelines on the Management of Thyroid Dysfunction following Immune Reconstitution Therapy.

Eur Thyroid J 2019 Jul 4;8(4):173-185. Epub 2019 Jul 4.

Thyroid Research Group, Division of Infection and Immunity, Cardiff University, Cardiff, United Kingdom.

Thyroid dysfunction (TD) frequently occurs as an autoimmune complication of immune reconstitution therapy (IRT), especially in individuals with multiple sclerosis treated with alemtuzumab, a pan-lymphocyte depleting drug with subsequent recovery of immune cell numbers. Less frequently, TD is triggered by highly active antiretroviral therapy (HAART) in patients infected with human immunodeficiency virus (HIV), or patients undergoing bone-marrow/hematopoietic-stem-cell transplantation (BMT/HSCT). In both alemtuzumab-induced TD and HIV/HAART patients, the commonest disorder is Graves' disease (GD), followed by hypothyroidism and thyroiditis; Graves' orbitopathy is observed in some GD patients. Read More

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http://dx.doi.org/10.1159/000500881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738237PMC
July 2019
10 Reads

Does subclinical hypothyroidism and/or thyroid autoimmunity influence the IVF/ICSI outcome? Review of the literature.

Gynecol Endocrinol 2019 ;35(sup1):56-59

St. Petersburg State University , St. Petersburg , Russia.

While overt hypothyroidism is a well-known risk factor for infertility, the association of subclinical hypothyroidism (SCH) or thyroid autoimmunity and reproductive failure has been still not elucidated. In this literature review, the current data on the effect of SCH and/or thyroid autoimmunity and human reproduction is presented. The main ART outcome measures are as follows: number of oocytes retrieved, fertilization rate, implantation rate, clinical pregnancy rate per embryo transfer, embryo quality, miscarriage rate, and live birth rate. Read More

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http://dx.doi.org/10.1080/09513590.2019.1653564DOI Listing
March 2020
2 Reads

Universal screening for thyroid disease during pregnancy should be performed.

Best Pract Res Clin Endocrinol Metab 2019 Sep 6:101320. Epub 2019 Sep 6.

Department of Obstetrics and Gynecology, University of Illinois College of Medicine at Chicago, 820 S. Wood Street, M/C 808, Chicago, IL 60612, USA. Electronic address:

Thyroid disease can significantly impact the pregnant woman and her child. Human and animal studies have firmly linked overt hypothyroidism and overt hyperthyroidism to miscarriage, preterm delivery and other adverse pregnancy outcomes. Overt hypothyroidism and overt hyperthyroidism affect 1% of all pregnancies. Read More

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http://dx.doi.org/10.1016/j.beem.2019.101320DOI Listing
September 2019
2 Reads

[Thyroid storm and exacerbation of autoimmune hemolytic anemia following childbirth].

Rinsho Ketsueki 2019 ;60(8):924-928

Department of Hematology, Gunma University Graduate School of Medicine.

A 32-year-old woman was diagnosed with autoimmune hemolytic anemia (AIHA) at 12 weeks of a pregnancy examination and followed up closely without treatment. At 40 weeks of gestation, she underwent emergency caesarean section because of premature rupture. On postoperative day one, the patient exhibited worsening hemolysis and tachycardia and developed high-output heart failure; she was diagnosed with Basedow disease based on the tachycardia pattern and thyroid storm based on the presence of hyperthyroidism, fever, tachycardia, and heart failure. Read More

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http://dx.doi.org/10.11406/rinketsu.60.924DOI Listing
September 2019
5 Reads

Association of Thyroid Function Test Abnormalities and Thyroid Autoimmunity With Preterm Birth: A Systematic Review and Meta-analysis.

JAMA 2019 08;322(7):632-641

Departments of Medical and Clinical Psychology, Tilburg University, Tilburg, the Netherlands.

Importance: Maternal hypothyroidism and hyperthyroidism are risk factors for preterm birth. Milder thyroid function test abnormalities and thyroid autoimmunity are more prevalent, but it remains controversial if these are associated with preterm birth.

Objective: To study if maternal thyroid function test abnormalities and thyroid autoimmunity are risk factors for preterm birth. Read More

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http://dx.doi.org/10.1001/jama.2019.10931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704759PMC
August 2019
10 Reads
35.289 Impact Factor

Thyroxine replacement for subfertile women with euthyroid autoimmune thyroid disease or subclinical hypothyroidism.

Cochrane Database Syst Rev 2019 06 25;6:CD011009. Epub 2019 Jun 25.

Reproductive Medicine, St Mary's Hospital, Hathersage Road, Manchester, UK, M13 0JH.

Background: Thyroid disease is the second most common endocrine disorder affecting women of reproductive age. Subclinical hypothyroidism is diagnosed by an elevated thyroid-stimulating hormone concentration with a normal concentration of free thyroxine hormone. Autoimmune thyroid disease (ATD) is diagnosed by the presence of thyroid autoantibodies, regardless of thyroid hormone levels. Read More

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http://dx.doi.org/10.1002/14651858.CD011009.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591496PMC
June 2019
7 Reads

Previous Live Births and Induced Abortions May Precede Later Development of Graves' Hyperthyroidism.

Eur Thyroid J 2019 Apr 14;8(2):70-78. Epub 2018 Dec 14.

Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark.

Objective: To investigate the association between reproductive history and later development of various nosological subtypes of overt hyperthyroidism.

Study Design: From the Danish population, we included incident hyperthyroid women, and for each case we recruited 4 euthyroid age-sex-region-matched controls from the same sub-population. Hyperthyroid cases/controls were: Graves' disease (GD, = 232/928), multinodular toxic goitre (MNTG, = 91/364), solitary toxic adenoma (STA, = 21/84). Read More

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http://dx.doi.org/10.1159/000494836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514508PMC
April 2019
21 Reads

Spontaneous pregnancies in patients with at least one failed IVF cycle after the management of autoimmune disorders, hereditary thrombophilia, and methylation disorders.

JBRA Assist Reprod 2019 10 14;23(4):361-366. Epub 2019 Oct 14.

Division of Perinatology, Department of Obstetrics and Gynecology, Hacettepe University, Ankara, Turkey.

Objective: This study aimed to describe the impact on achieving spontaneous pregnancy of treating patients with at least one failed in-vitro fertilization (IVF) cycle for autoimmune disorders, hereditary thrombophilia, and methylation disorders.

Methods: Fifty-three patients who met the enrollment criteria seen between January 2007 and October 2017 were included in this retrospective cohort study. The patients were retrospectively assessed for the presence of hereditary thrombophilia, methylenetetrahydrofolate reductase (MTHFR) polymorphisms, serum vitamin B12/folate/homocysteine levels, and autoimmune antibody positivity. Read More

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http://dx.doi.org/10.5935/1518-0557.20190034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798589PMC
October 2019
27 Reads

Selenium supplementation in the management of thyroid autoimmunity during pregnancy: results of the "SERENA study", a randomized, double-blind, placebo-controlled trial.

Endocrine 2019 12 25;66(3):542-550. Epub 2019 May 25.

Department of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy.

Purpose: Selenium is frequently in nutraceuticals for pregnancy, given its role on fertility and thyroid metabolism. However, most evidence rise from non-controlled studies. We aimed to evaluate the protective effect of selenium against thyroid autoimmunity during and after pregnancy. Read More

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http://link.springer.com/10.1007/s12020-019-01958-1
Publisher Site
http://dx.doi.org/10.1007/s12020-019-01958-1DOI Listing
December 2019
3 Reads

[Immunoregulatory proteins and cytokines in the blood of patients with Graves' disease].

Probl Endokrinol (Mosk) 2019 05 14;65(1):4-9. Epub 2019 May 14.

Novokuznetsk State Institute for Further Training of Physicians - Branch Campus of the Russian Medical Academy of Continuous Professional Education.

Background: Immunoregulatory proteins (alpha-2-macroglobulin, lactoferrin) actively participate in inflammatory and autoimmune processes, affect synthesis and transport of hormones and cytokines, and control cell proliferation and apoptosis. However, the role of these proteins in the pathogenesis of Graves' disease (GD) is poorly understood. Objective - the study objective was to determine blood levels of alpha-2-macroglobulin (α2-MG), lactoferrin (LF), and cytokines (TNF-α, IL-6, IL-8, and IFN-γ) in GD. Read More

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http://dx.doi.org/10.14341/probl9567DOI Listing
May 2019
4 Reads

Spontaneously regressing acral congenital leucoderma.

Australas J Dermatol 2019 Nov 14;60(4):e351-e352. Epub 2019 Apr 14.

Department of Dermatology, Venereology and Leprosy, Sri Manakula Vinayagar Medical College and Hospital, Pondicherry University, Pondicherry, India.

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http://dx.doi.org/10.1111/ajd.13055DOI Listing
November 2019
4 Reads
0.982 Impact Factor

Three Consecutive Pregnancies in a Patient with Chronic Autoimmune Thyroid Disease Associated with Hypothyroidism and Extremely High Levels of Anti-Thyrotropin Receptor Antibodies.

Thyroid 2019 05;29(5):743-747

1 Service d'Endocrinologie - Diabète - Nutrition Reims, Centre Hospitalier Universitaire de Reims, Champagne-Ardenne, France.

Thyroid-stimulating hormone (TSH) receptor (TSHR) antibodies (TRAb) can be present in chronic autoimmune thyroiditis. Transplacental TRAb transfer can lead to fetal thyroid dysfunction and serious complications. We report the case of a woman with autoimmune hypothyroidism and extremely high TRAb levels, with blocking and stimulating activities (biological activities characterized with Chinese hamster ovary cells expressing TSHR). Read More

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https://www.liebertpub.com/doi/10.1089/thy.2018.0098
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http://dx.doi.org/10.1089/thy.2018.0098DOI Listing
May 2019
31 Reads

[Hashimoto thyroiditis, therapeutic options and extrathyroidal options - an up-to-date overview].

Wien Med Wochenschr 2020 Feb 27;170(1-2):26-34. Epub 2019 Mar 27.

Institut für Schilddrüsendiagnostik und Nuklearmedizin Gleisdorf, Businesspark 2, 8200, Gleisdorf, Austria.

Hashimoto's thyroiditis is one of the most common organspecific autoimune diseases and the most frequent cause of hypothyroidism in areas with sufficient iodine supply. Excessively stimulated T cells CD4+ and their differentiated cells are known to play a key role in the pathogenesis. It is currently accepted that on the one hand genetic susceptibility, environmental factors, existential factors (gender difference) play an important role, on the other hand gut and intestinal microbiota seem to contribute to its development too. Read More

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http://dx.doi.org/10.1007/s10354-019-0691-1DOI Listing
February 2020
5 Reads

Association of Overt and Subclinical Hyperthyroidism During Weeks 4-8 with Adverse Pregnancy Outcomes.

J Womens Health (Larchmt) 2019 06 11;28(6):842-848. Epub 2019 Mar 11.

1 Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang, P.R. China.

Although increasing data suggest that hyperthyroidism is associated with adverse pregnancy outcomes, there are only a few reports with different conclusions on whether the mild transient reduction in thyrotropin (TSH) with or without free thyroxine (FT4) elevation during the early stage of pregnancy also causes adverse pregnancy outcomes. We analyzed data from 3,783 women in this study from August 2011 to December 2013. Participants completed a questionnaire survey. Read More

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http://dx.doi.org/10.1089/jwh.2018.7180DOI Listing
June 2019
14 Reads
1.896 Impact Factor

Stable consumption of swordfish favors, whereas stable consumption of oily fish protects from, development of postpartum thyroiditis.

Endocrine 2019 07 6;65(1):94-101. Epub 2019 Mar 6.

Department of Human Pathology Gaetano Barresi, University of Messina, Messina, Italy.

Purpose: In 236 pregnant women, we showed that selective or predominant consumption of swordfish (group A) was associated with high rates of positivity for serum thyroid autoantibodies (TPOAb and TgAb) throughout day 4 postpartum. In contrast, selective or predominant consumption of oily fish (group B) was associated with TPOAb and TgAb negativity. Rates were intermediate in group C (scanty consumption of swordfish) and group D (consumption of fish other than swordfish and oily fish). Read More

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http://dx.doi.org/10.1007/s12020-019-01882-4DOI Listing
July 2019
3 Reads

The Impact of Autoantibodies on IVF Treatment and Outcome: A Systematic Review.

Int J Mol Sci 2019 Feb 19;20(4). Epub 2019 Feb 19.

Department of Physiology, Medical School, National and Kapodistrian University of Athens, 75, Mikras Asias, 11527 Athens, Greece.

The role of autoantibodies in in vitro fertilization (IVF) has been discussed for almost three decades. Nonetheless, studies are still scarce and widely controversial. The aim of this study is to provide a comprehensive systematic review on the possible complications associated to autoantibodies (AA) impeding the chances of a successful IVF cycle. Read More

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http://dx.doi.org/10.3390/ijms20040892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412530PMC
February 2019
22 Reads

Pregnancy Week-Specific Reference Ranges for Thyrotropin and Free Thyroxine in the North Denmark Region Pregnancy Cohort.

Thyroid 2019 03 27;29(3):430-438. Epub 2019 Feb 27.

1 Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark.

Background: Physiological changes in maternal thyroid function during pregnancy necessitate the use of pregnancy-specific reference ranges. Dynamic changes in thyrotropin (TSH) within the first trimester of pregnancy have been reported, but more evidence is needed to substantiate the findings. The objective of this study was to estimate pregnancy week-specific reference ranges for maternal TSH and free thyroxine (fT4) in early pregnancy. Read More

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http://dx.doi.org/10.1089/thy.2018.0628DOI Listing
March 2019
9 Reads

[Update Graves' disease 2019].

Dtsch Med Wochenschr 2019 02 31;144(3):152-155. Epub 2019 Jan 31.

Funktionsbereich Spezielle Endokrinologie, Universitätsklinikum Düsseldorf.

Diagnosis: Also accordingly to the recent European Thyroid Association Guidelines 2018, TSH receptor antibody (TRAb) measurement is highly sensitive and specific for the detection of Graves' disease (GD) and to distinguish from autoimmune thyroiditis (AIT). Bioassays are used for distinguishing stimulating from blocking antibodies and are used for scientific questions.

Therapy: According to the current guidelines - and with exception for pregnant women - the use of thiamazol/carbimazole is generally favored from propylthiouracil (PTU). Read More

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http://dx.doi.org/10.1055/a-0660-6046DOI Listing
February 2019
40 Reads

Evaluation of the impact of levothyroxine treatment on the psychomotor developmental status of three-year-old children born to mothers with mild thyroid impairment; Tehran Thyroid and pregnancy study: study protocol for a randomized clinical trial.

Trials 2019 Jan 28;20(1):86. Epub 2019 Jan 28.

Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Despite the known adverse effects of maternal overt hypothyroidism on the neurocognitive development of children, there is uncertainty regarding the impact of gestational thyroid dysfunction or autoimmune thyroiditis on infant/child neurological development. This study aims to evaluate the impact of levothyroxine (LT4) treatment on the psychomotor developmental status of three-year-old children born to mothers with mild thyroid impairment (subclinical hypothyroidismwith/without autoimmune thyroiditis).

Methods/design: This is a follow-up study of the Tehran Thyroid and Pregnancy Study, a randomized trial in which subclinical hypothyroid pregnant women were assigned to an intervention group (treated with levothyroxine) or a control group (received no treatment). Read More

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http://dx.doi.org/10.1186/s13063-018-3130-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350327PMC
January 2019
17 Reads

Thyroid Dysfunction and Diabetes Mellitus: Two Closely Associated Disorders.

Endocr Rev 2019 06;40(3):789-824

Department of Medicine, Division of Endocrinology and Metabolism, University of Washington School of Medicine, Seattle, Washington.

Thyroid dysfunction and diabetes mellitus are closely linked. Several studies have documented the increased prevalence of thyroid disorders in patients with diabetes mellitus and vice versa. This review critically discusses the different underlying mechanisms linking type 1 and 2 diabetes and thyroid dysfunction to demonstrate that the association of these two common disorders is unlikely a simple coincidence. Read More

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https://academic.oup.com/edrv/advance-article/doi/10.1210/er
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http://dx.doi.org/10.1210/er.2018-00163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6507635PMC
June 2019
54 Reads

A 2018 Italian and Romanian Survey on Subclinical Hypothyroidism in Pregnancy.

Eur Thyroid J 2018 Nov 26;7(6):294-301. Epub 2018 Jul 26.

Department of Endocrinology, Carol Davila University of Medicine of Pharmacy, Bucharest, Romania.

Objectives: Pregnancy induces changes in thyroid function, and thyroid dysfunction during gestation is associated with adverse outcomes. We examined the management of subclinical hypothyroidism and chronic autoimmune thyroiditis in pregnancy among Italian and Romanian endocrinologists.

Methods: Members of the Associazione Medici Endocrinologi (AME) and Romanian Society of Endocrinology (RSE) were invited to participate in a web-based survey investigating the topic. Read More

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https://www.karger.com/Article/FullText/490944
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http://dx.doi.org/10.1159/000490944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276751PMC
November 2018
51 Reads

Thyroid function and thyroid disorders during pregnancy: a review and care pathway.

Arch Gynecol Obstet 2019 02 19;299(2):327-338. Epub 2018 Dec 19.

Department of Medical, Surgical and Experimental Sciences, University of Sassari, 07100, Sassari, Italy.

Purpose: To review the literature on thyroid function and thyroid disorders during pregnancy.

Methods: A detailed literature research on MEDLINE, Cochrane library, EMBASE, NLH, ClinicalTrials.gov, and Google Scholar databases was done up to January 2018 with restriction to English language about articles regarding thyroid diseases and pregnancy. Read More

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http://dx.doi.org/10.1007/s00404-018-5018-8DOI Listing
February 2019
15 Reads

Resistance to thyroid hormone β in autoimmune thyroid disease: a case report and review of literature.

BMC Pregnancy Childbirth 2018 Dec 3;18(1):468. Epub 2018 Dec 3.

Department of Endocrinology and Metabolism, The Endocrine Institute and The Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Hospital of China Medical University, 155 Nanjing Bei Street, Shenyang, Liaoning, 110001, People's Republic of China.

Background: Resistance to thyroid hormone beta (RTHβ) results in symptoms of both increased and decreased thyroid hormone action. The effect of thyroid hormone changes in different types of autoimmune thyroid disease (AITD) in RTHβ is dynamic.

Case Presentation: A 25-year-old Asian female had a RTHβ Y321C mutation with Hashimoto's thyroiditis and type 2 diabetes mellitus. Read More

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http://dx.doi.org/10.1186/s12884-018-2110-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288951PMC
December 2018
9 Reads
2.190 Impact Factor