998 results match your criteria Autoimmune Thyroid Disease and Pregnancy


Three consecutive pregnancies in a patient with chronic autoimmune thyroid disease associated with hypothyroidism and extremely high levels of anti-TSH receptor antibodies.

Thyroid 2019 Apr 11. Epub 2019 Apr 11.

Centre Hospitalier Universitaire de Reims, 26992, Service d'Endocrinologie - Diabète - Nutrition, Reims, Champagne-Ardenne, France.

Background: Thyroid-stimulating hormone (TSH) receptor (TSHR) antibodies (TRAb) can be present in chronic autoimmune thyroiditis. Transplacental TRAb transfer can lead to fetal thyroid dysfunction and serious complications.

Patient Findings: We report the case of a woman with autoimmune hypothyroidism and extremely high TRAb levels, with blocking and stimulating activities (biological activities characterized with Chinese hamster ovary cells expressing TSHR). Read More

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https://www.liebertpub.com/doi/10.1089/thy.2018.0098
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http://dx.doi.org/10.1089/thy.2018.0098DOI Listing
April 2019
3 Reads

[Hashimoto thyroiditis, therapeutic options and extrathyroidal options - an up-to-date overview].

Wien Med Wochenschr 2019 Mar 27. Epub 2019 Mar 27.

Institut für Schilddrüsendiagnostik und Nuklearmedizin Gleisdorf, Businesspark 2, 8200, Gleisdorf, Austria.

Hashimoto's thyroiditis is one of the most common organspecific autoimune diseases and the most frequent cause of hypothyroidism in areas with sufficient iodine supply. Excessively stimulated T cells CD4+ and their differentiated cells are known to play a key role in the pathogenesis. It is currently accepted that on the one hand genetic susceptibility, environmental factors, existential factors (gender difference) play an important role, on the other hand gut and intestinal microbiota seem to contribute to its development too. Read More

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http://dx.doi.org/10.1007/s10354-019-0691-1DOI Listing
March 2019
1 Read

Association of Overt and Subclinical Hyperthyroidism During Weeks 4-8 with Adverse Pregnancy Outcomes.

J Womens Health (Larchmt) 2019 Mar 11. Epub 2019 Mar 11.

1 Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang, P.R. China.

Background: Although increasing data suggest that hyperthyroidism is associated with adverse pregnancy outcomes, there are only a few reports with different conclusions on whether the mild transient reduction in thyrotropin (TSH) with or without free thyroxine (FT4) elevation during the early stage of pregnancy also causes adverse pregnancy outcomes.

Subjects And Methods: We analyzed data from 3,783 women in this study from August 2011 to December 2013. Participants completed a questionnaire survey. Read More

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http://dx.doi.org/10.1089/jwh.2018.7180DOI Listing
March 2019
4 Reads
1.896 Impact Factor

The Impact of Autoantibodies on IVF Treatment and Outcome: A Systematic Review.

Int J Mol Sci 2019 Feb 19;20(4). Epub 2019 Feb 19.

Department of Physiology, Medical School, National and Kapodistrian University of Athens, 75, Mikras Asias, 11527 Athens, Greece.

The role of autoantibodies in in vitro fertilization (IVF) has been discussed for almost three decades. Nonetheless, studies are still scarce and widely controversial. The aim of this study is to provide a comprehensive systematic review on the possible complications associated to autoantibodies (AA) impeding the chances of a successful IVF cycle. Read More

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http://dx.doi.org/10.3390/ijms20040892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412530PMC
February 2019
1 Read

Pregnancy Week-Specific Reference Ranges for Thyrotropin and Free Thyroxine in the North Denmark Region Pregnancy Cohort.

Thyroid 2019 Mar 27;29(3):430-438. Epub 2019 Feb 27.

1 Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark.

Background: Physiological changes in maternal thyroid function during pregnancy necessitate the use of pregnancy-specific reference ranges. Dynamic changes in thyrotropin (TSH) within the first trimester of pregnancy have been reported, but more evidence is needed to substantiate the findings. The objective of this study was to estimate pregnancy week-specific reference ranges for maternal TSH and free thyroxine (fT4) in early pregnancy. Read More

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http://dx.doi.org/10.1089/thy.2018.0628DOI Listing
March 2019
2 Reads

[Update Graves' disease 2019].

Dtsch Med Wochenschr 2019 02 31;144(3):152-155. Epub 2019 Jan 31.

Funktionsbereich Spezielle Endokrinologie, Universitätsklinikum Düsseldorf.

Diagnosis: Also accordingly to the recent European Thyroid Association Guidelines 2018, TSH receptor antibody (TRAb) measurement is highly sensitive and specific for the detection of Graves' disease (GD) and to distinguish from autoimmune thyroiditis (AIT). Bioassays are used for distinguishing stimulating from blocking antibodies and are used for scientific questions.

Therapy: According to the current guidelines - and with exception for pregnant women - the use of thiamazol/carbimazole is generally favored from propylthiouracil (PTU). Read More

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http://dx.doi.org/10.1055/a-0660-6046DOI Listing
February 2019
20 Reads

A 2018 Italian and Romanian Survey on Subclinical Hypothyroidism in Pregnancy.

Eur Thyroid J 2018 Nov 26;7(6):294-301. Epub 2018 Jul 26.

Department of Endocrinology, Carol Davila University of Medicine of Pharmacy, Bucharest, Romania.

Objectives: Pregnancy induces changes in thyroid function, and thyroid dysfunction during gestation is associated with adverse outcomes. We examined the management of subclinical hypothyroidism and chronic autoimmune thyroiditis in pregnancy among Italian and Romanian endocrinologists.

Methods: Members of the Associazione Medici Endocrinologi (AME) and Romanian Society of Endocrinology (RSE) were invited to participate in a web-based survey investigating the topic. Read More

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https://www.karger.com/Article/FullText/490944
Publisher Site
http://dx.doi.org/10.1159/000490944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276751PMC
November 2018
21 Reads

Thyroid function and thyroid disorders during pregnancy: a review and care pathway.

Arch Gynecol Obstet 2019 Feb 19;299(2):327-338. Epub 2018 Dec 19.

Department of Medical, Surgical and Experimental Sciences, University of Sassari, 07100, Sassari, Italy.

Purpose: To review the literature on thyroid function and thyroid disorders during pregnancy.

Methods: A detailed literature research on MEDLINE, Cochrane library, EMBASE, NLH, ClinicalTrials.gov, and Google Scholar databases was done up to January 2018 with restriction to English language about articles regarding thyroid diseases and pregnancy. Read More

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http://dx.doi.org/10.1007/s00404-018-5018-8DOI Listing
February 2019
5 Reads

Resistance to thyroid hormone β in autoimmune thyroid disease: a case report and review of literature.

BMC Pregnancy Childbirth 2018 Dec 3;18(1):468. Epub 2018 Dec 3.

Department of Endocrinology and Metabolism, The Endocrine Institute and The Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Hospital of China Medical University, 155 Nanjing Bei Street, Shenyang, Liaoning, 110001, People's Republic of China.

Background: Resistance to thyroid hormone beta (RTHβ) results in symptoms of both increased and decreased thyroid hormone action. The effect of thyroid hormone changes in different types of autoimmune thyroid disease (AITD) in RTHβ is dynamic.

Case Presentation: A 25-year-old Asian female had a RTHβ Y321C mutation with Hashimoto's thyroiditis and type 2 diabetes mellitus. Read More

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http://dx.doi.org/10.1186/s12884-018-2110-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288951PMC
December 2018
4 Reads
2.190 Impact Factor

Thyrotropin receptor antibody: A novel risk indicator for pregnancy loss.

Clin Biochem 2019 Feb 1;64:44-48. Epub 2018 Dec 1.

Department of Transfusion Medicine, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, PR China. Electronic address:

Background: Thyroid autoantibody has been associated with adverse pregnancy outcomes. However, thyroid-receptor antibody (TRAb) has not been considered as a potential risk assessment indicator for adverse pregnancy outcomes. Therefore, we assessed the role of TRAb in evaluation of the risk of adverse pregnancy outcomes. Read More

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http://dx.doi.org/10.1016/j.clinbiochem.2018.11.017DOI Listing
February 2019
4 Reads

Optimization of the follow-up of pregnant women with autoimmune thyroid disease.

Endocrinol Diabetes Nutr 2019 May 16;66(5):305-311. Epub 2018 Nov 16.

Servicio de Endocrinología y Nutrición, Complejo Hospitalario de Navarra, Pamplona, Navarra, España; Instituto de Investigación Sanitaria de Navarra (IdisNa), Pamplona, Navarra, España.

Objective: To determine the risk of hypothyroidism in pregnant women with autoimmune thyroid disease and thyrotropin (TSH) < 2,5 mIU/l at the beginning of pregnancy.

Methods: Prospective longitudinal study of pregnant women with no personal history of thyroid disease, and with TSH < 2.5 mIU/l in the first trimester. Read More

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http://dx.doi.org/10.1016/j.endinu.2018.08.011DOI Listing
May 2019
8 Reads

Pancreatic autoimmunity: An unknown etiology on patients with assisted reproductive techniques (ART)-recurrent reproductive failure.

PLoS One 2018 22;13(10):e0203446. Epub 2018 Oct 22.

Department of Immunology and Department of Reproductive Endocrinology and Infertility, Valentian Infertility Institute (IVI), IVI RMA, Madrid, Madrid, Spain.

Pancreatic Autoimmunity is defined as the presence of autoantibodies and more frequent need for insulin treatment. Affected women presenting recurrent implantation failure (RIF) or recurrent miscarriage (RM) are often misdiagnosed. The objective of thestudy was to describe clinical and metabolic profiles suggestive of Pancreatic Autoimmunity and therapeutic strategy in patients with RIF/RM. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0203446PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197630PMC
March 2019
12 Reads

2018 European Thyroid Association Guideline for the Management of Graves' Hyperthyroidism.

Eur Thyroid J 2018 Aug 25;7(4):167-186. Epub 2018 Jul 25.

Department of Endocrinology, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.

Graves' disease (GD) is a systemic autoimmune disorder characterized by the infiltration of thyroid antigen-specific T cells into thyroid-stimulating hormone receptor (TSH-R)-expressing tissues. Stimulatory autoantibodies (Ab) in GD activate the TSH-R leading to thyroid hyperplasia and unregulated thyroid hormone production and secretion. Diagnosis of GD is straightforward in a patient with biochemically confirmed thyrotoxicosis, positive TSH-R-Ab, a hypervascular and hypoechoic thyroid gland (ultrasound), and associated orbitopathy. Read More

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http://dx.doi.org/10.1159/000490384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140607PMC
August 2018
54 Reads

Effect of levothyroxine supplementation on pregnancy outcomes in women with subclinical hypothyroidism and thyroid autoimmuneity undergoing in vitro fertilization/intracytoplasmic sperm injection: an updated meta-analysis of randomized controlled trials.

Reprod Biol Endocrinol 2018 Sep 24;16(1):92. Epub 2018 Sep 24.

Department of Reproduction and Genetics, the First Affiliated Hospital of Kunming Medical University, No. 295 Xi Chang road, Kunming, 650032, China.

Background: Evidence suggests that subclinical hypothyroidism (SCH) and thyroid autoimmunity (TAI) are associated with adverse pregnancy outcomes. This systematic review and meta-analysis was conducted to determine whether levothyroxine (LT4) supplementation would improve pregnancy outcomes among infertile women with SCH and/or TAI who underwent in vitro fertilization (IVF) or intracytoplastic sperm injection (ICSI).

Methods: We searched databases of PubMed, EMBASE, Web of Science, Cochrane Controlled Trials Register databases, and Clinicaltrials. Read More

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https://rbej.biomedcentral.com/articles/10.1186/s12958-018-0
Publisher Site
http://dx.doi.org/10.1186/s12958-018-0410-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154908PMC
September 2018
4 Reads

Seasonality of month of birth in children and adolescents with autoimmune thyroiditis: a continuing conundrum.

J Pediatr Endocrinol Metab 2018 Oct;31(10):1123-1131

4th Department of Pediatrics, Faculty of Health Sciences, Medical School, Aristotle University of Thessaloniki, Papageorgiou General Hospital, Thessaloniki, Greece.

Background The aim of this study was to analyze the seasonal birth month pattern in young patients with autoimmune thyroiditis and compare it with youth controls. Methods Medical records of a total of 298 children and adolescents of Greek origin, with a diagnosis of Hashimoto thyroiditis (HT) before the age of 21 years that were born from 1987 to 2010 were retrospectively reviewed. In addition, 298 consecutive subjects that were born from 1988 to 2012 and evaluated in a tertiary unit for any reason, served as controls, provided that they had no personal or family history of thyroid or any other autoimmune disease. Read More

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http://dx.doi.org/10.1515/jpem-2018-0051DOI Listing
October 2018
5 Reads

[Recommendations for the diagnosis and follow up of the foetus and newborn child born to mothers with autoimmune thyroid disease].

An Pediatr (Barc) 2018 Oct 1;89(4):254.e1-254.e7. Epub 2018 Sep 1.

Unidad de Metabolismo y Desarrollo, Hospital General Universitario Gregorio Marañón , Madrid, España.

The objective of this document is to review the current recommendations in the management of the foetus and the newborn child born to mothers with autoimmune thyroid disease. In 2017, the American Thyroid Association published guidelines for the diagnosis and management of thyroid disease during pregnancy and post-partum. In this guide, 97 recommendations were made, and an algorithm for the diagnosis and treatment of gestational hypothyroidism was proposed. Read More

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http://dx.doi.org/10.1016/j.anpedi.2018.07.006DOI Listing
October 2018
20 Reads

Does severe vitamin D deficiency impact obstetric outcomes in pregnant women with thyroid autoimmunity?

J Matern Fetal Neonatal Med 2018 Sep 25:1-11. Epub 2018 Sep 25.

b Faculty of Medicine, Division of Biostatistics , Marmara University , Istanbul , Turkey.

Purpose: Vitamin D plays an important role in the modulation of the immune system and anti-autoimmune activities. Autoimmune thyroid diseases related to endocrine disorders are associated with poor obstetric outcomes in pregnancy. Herein, we aimed to investigate the contribution of vitamin D hypovitaminosis to poor pregnancy outcomes in pregnant women with the positive autoimmune antibody. Read More

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http://dx.doi.org/10.1080/14767058.2018.1519017DOI Listing
September 2018
4 Reads

Estradiol Affects Epstein-Barr Virus Reactivation-Induced Thyrotropin Receptor Antibody and Immunoglobulin Production in Graves' Disease Patients and Healthy Controls.

Viral Immunol 2018 09 22;31(7):486-491. Epub 2018 Aug 22.

1 Division of Molecular Pathology, Department of Pathology, Faculty of Medicine, Tottori University , Yonago, Japan .

Epstein-Barr virus (EBV) is a gamma-herpesvirus persisting mainly in human B lymphocytes. EBV reactivation induces host cells to differentiate into plasma cells and is related to autoimmune diseases. Graves' disease, an autoimmune hyperthyroidism, is caused by the thyrotropin receptor antibody (TRAb), which overstimulates thyroid stimulating hormone receptor. Read More

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http://dx.doi.org/10.1089/vim.2018.0032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145039PMC
September 2018
19 Reads

Fetal Goitrous Hypothyroidism and Polyhydramnios in a Patient with Compound Heterozygous DUOXA2 Mutations.

Horm Res Paediatr 2018 15;90(2):132-137. Epub 2018 Aug 15.

Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan.

Background: Fetal goiter is only rarely observed in pregnant women without autoimmune thyroid disorders, and there is no epidemiological data on its pathophysiology. Dual oxidase maturation factor 2 (DUOXA2), together with dual oxidase 2, serves pivotal roles in thyroid hormone biosynthesis. To date, all reported patients with DUOXA2 mutations were diagnosed postnatally through newborn screening for congenital hypothyroidism. Read More

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https://www.karger.com/Article/FullText/491104
Publisher Site
http://dx.doi.org/10.1159/000491104DOI Listing
January 2019
12 Reads

Type 1 diabetes impairs female fertility even before it is diagnosed.

Diabetes Res Clin Pract 2018 Sep 9;143:151-158. Epub 2018 Jul 9.

Health Information and Epidemiology Laboratory of Chang Gung, Memorial Hospital Chiayi Branch, Chiayi County, Taiwan; Department of Traditional Chinese Medicine, Chang Gung Memorial, Hospital Chiayi Branch, Chiayi County, Taiwan and School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Aims: The aim of this study was to assess the fertility rate in Taiwanese women before and after a diagnosis of type 1 diabetes. The potential risk factors which may have influenced fertility were also investigated.

Methods: We conducted this retrospective, nationwide, population-based, matched cohort study using data from the Taiwan National Health Insurance Research Database. Read More

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http://dx.doi.org/10.1016/j.diabres.2018.07.010DOI Listing
September 2018
45 Reads

Gestational Hypothyroxinemia Affects Its Offspring With a Reduced Suppressive Capacity Impairing the Outcome of the Experimental Autoimmune Encephalomyelitis.

Front Immunol 2018 6;9:1257. Epub 2018 Jun 6.

Departamento de Ciencias Biológicas, Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago, Chile.

Hypothyroxinemia (Hpx) is a thyroid hormone deficiency (THD) condition highly frequent during pregnancy, which although asymptomatic for the mother, it can impair the cognitive function of the offspring. Previous studies have shown that maternal hypothyroidism increases the severity of experimental autoimmune encephalomyelitis (EAE), an autoimmune disease model for multiple sclerosis (MS). Here, we analyzed the immune response after EAE induction in the adult offspring gestated in Hpx. Read More

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http://dx.doi.org/10.3389/fimmu.2018.01257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997919PMC
June 2018
21 Reads

IMPORTANCE OF ISOLATED GESTATIONAL HYPOTHYROXINEMIA IN THE DEVELOPMENT OF OBSTETRIC AND SOMATIC PATHOLOGIES.

Georgian Med News 2018 May(278):39-45

Tbilisi State Medical University; "David Gagua Clinic" Ltd., Tbilisi, Georgia.

The isolated hypothyroxinemia of pregnancy (IHP) has gained specific attention in the specialized literature during the recent years as the possible factor impeding the intellectual development of fetus and increasing the risk of complications related with pregnancy, delivery and perinatal period. Aim of the study was to define the importance of isolated hypothyroxinemia in the development of obstetric and somatic pathologies in outpatient population of pregnant females. The study of prospective design was performed at the base of "David Gagua Clinic" Ltd. Read More

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May 2018
6 Reads

Telomere length, thyroid dysfunction/autoimmunity and parity.

Med Hypotheses 2018 Jul 17;116:28-29. Epub 2018 Apr 17.

Endocrine Unit, Department of Obstetrics and Gynecology, Athens University Medical School, Aretaieion University Hospital, Athens, Greece.

There may exist an association between thyroid dysfunction/autoimmunity and parity. Autoimmune thyroiditis shows some degree of telomere shortening. Parity was recently found to be associated with telomere shortening. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03069877183028
Publisher Site
http://dx.doi.org/10.1016/j.mehy.2018.04.015DOI Listing
July 2018
4 Reads

Thyrotropin Receptor Antibodies-An Overview.

Ophthalmic Plast Reconstr Surg 2018 Jul/Aug;34(4S Suppl 1):S20-S27

Department of Medicine and Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota, U.S.A.

Purpose: Thyroid autoimmunity affects approximately 5% of the population, and its investigation relies heavily on the use of autoantibodies. Thyroid stimulating hormone receptor (TSHR) autoantibodies (TRAb) play a central role in the evaluation of Graves disease (GD), Graves ophthalmopathy (GO) and pretibial myxedema (PTM). However, there is still controversy regarding overall TRAb assay diagnostic accuracy and their prognostic utility. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001052DOI Listing
August 2018
5 Reads

The impact of autoimmunity-related early ovarian aging on ICSI cycle outcome.

Gynecol Endocrinol 2018 May 4:1-4. Epub 2018 May 4.

a Department of Obstetrics and Gynecology , Zeynep Kamil Maternity/Children, Education and Training Hospital , Istanbul , Turkey.

The aim of this study was to investigate the impact of anti-thyroid peroxidase antibodies (Anti-TPO) on the in vitro fertilization and embryo transfer (IVF-ET) outcome in women with poor ovarian reserve but normal thyrotropin levels. A total of 300 patients with poor ovarian reserve undergoing ICSI cycle from April 2015 to December 2017 were analyzed retrospectively. Subjects were divided into two groups: Group 1: Women with early ovarian aging, Group 2: Women with age related poor ovarian reserve. Read More

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http://dx.doi.org/10.1080/09513590.2018.1469612DOI Listing
May 2018
7 Reads

Management of Subclinical Hypothyroidism in Pregnancy: A Comment from the Italian Society of Endocrinology and the Italian Thyroid Association to the 2017 American Thyroid Association Guidelines-"The Italian Way".

Thyroid 2018 05;28(5):551-555

4 Department of Clinical and Experimental Medicine, Endocrinology Section, University of Pisa , Pisa, Italy .

The 2017 American Thyroid Association guidelines for the diagnosis and management of thyroid disease during pregnancy and the postpartum were published six years after the previous ones. They provide comprehensive clinical recommendations for the whole spectrum of thyroid diseases, as well as for optimal iodine intake during pregnancy, postpartum, and lactation. The present position statement mainly regards the recommended flow chart for therapeutic decision making in pregnant women being diagnosed with subclinical hypothyroidism. Read More

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http://dx.doi.org/10.1089/thy.2017.0424DOI Listing
May 2018
2 Reads

Cesarean delivery: A predisposing factor for autoimmune thyroid disease in iodine replete women?

Eur J Obstet Gynecol Reprod Biol 2018 05 12;224:131-132. Epub 2018 Mar 12.

Ankara University, Department of Obstetrics and Gynecology, Ankara, Turkey.

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http://dx.doi.org/10.1016/j.ejogrb.2018.03.010DOI Listing
May 2018
1 Read

Hyperthyroidism in an infant of a mother with autoimmune hypothyroidism with positive TSH receptor antibodies.

J Pediatr Endocrinol Metab 2018 Apr;31(5):577-580

Murdoch Children's Research Institute, Parkville, Victoria, Australia.

Background: Neonatal hyperthyroidism is rare, seen in infants of mothers with Graves' disease (GD), with transplacental transfer of thyroid-stimulating hormone receptor (TSHR) antibodies (TRAbs). We describe a neonate with severe hyperthyroidism due to TRAbs, born to a mother with autoimmune hypothyroidism.

Case Presentation: A baby boy born preterm at 35 weeks had irritability, tachycardia and proptosis after birth. Read More

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http://dx.doi.org/10.1515/jpem-2017-0425DOI Listing
April 2018
5 Reads

Associated conditions in patients with multiple dermatofibromas: Case reports and literature review.

Dermatol Online J 2017 Sep 22;23(9). Epub 2017 Sep 22.

Department of Internal Medicine, Scripps Mercy Hospital, San Diego, California.

Dermatofibromas are benign, fibrohistiocytic, dermal tumors. Solitary dermatofibromas may be incidental findings, whereas multiple dermatofibromas may be associated with systemic conditions or previous therapies. Two women and one man with multiple dermatofibromas and an associated systemic condition, immunosuppression, or both, are described. Read More

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September 2017
8 Reads

Neonatal Thyrotoxicosis.

Clin Perinatol 2018 03 16;45(1):31-40. Epub 2017 Dec 16.

Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, The Thyroid Center, 3401 Civic Center Boulevard, Philadelphia, PA 19104, USA. Electronic address:

Neonatal thyrotoxicosis (hyperthyroidism) is less prevalent than congenital hypothyroidism; however, it can lead to significant morbidity and mortality if not promptly recognized and adequately treated. Most cases are transient, secondary to maternal autoimmune hyperthyroidism (Graves disease [GD]). This article summarizes recommendations for screening and management of hyperthyroidism in both the fetal and neonatal periods, with a focus on neonatal thyrotoxicosis secondary to maternal GD. Read More

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http://dx.doi.org/10.1016/j.clp.2017.10.001DOI Listing
March 2018
5 Reads

Turner Syndrome: Diagnostic and Management Considerations for Perinatal Clinicians.

Clin Perinatol 2018 03;45(1):119-128

Division of Endocrinology, Cincinnati Children's Hospital Medical Center, The University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, USA. Electronic address:

The perinatal clinician needs to understand certain essential concepts when encountering an infant with a suspected or confirmed diagnosis of Turner syndrome. This article describes the key clinical features that should prompt testing, the appropriate diagnostic workup, the necessary screening required after diagnosis, and how to best approach family counseling. Read More

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http://dx.doi.org/10.1016/j.clp.2017.11.003DOI Listing
March 2018
4 Reads

Insulin autoimmune syndrome in a pregnant female: A rare case report.

Medicine (Baltimore) 2017 Dec;96(51):e9213

Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

Rationale: Insulin autoimmune syndrome (IAS) is an uncommon disorder characterized by hyperinsulinemic hypoglycemia related to insulin-binding autoantibodies. To the best of our knowledge, we report the first case of a pregnant female with IAS.

Patient Concerns: The 26-year-old patient with Graves disease and 10 weeks pregnant developed IAS after approximately 6 months treatment with methimazole. Read More

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http://dx.doi.org/10.1097/MD.0000000000009213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758171PMC
December 2017
84 Reads

Thyroid and Assisted Reproduction Technologies: A Brief Clinical Update with Recommendations for Practice.

Authors:
Roberto Negro

Endocr Metab Immune Disord Drug Targets 2018 ;18(3):194-200

Division of Endocrinology, "V. Fazzi" Hospital, Piazza Muratore, 1. 73100, Lecce, Italy.

Background And Objective: Infertility is a common disease that in about one third of cases has a female cause and often requires assisted reproduction technologies (ART) to conceive. Also thyroid autoimmunity (TAI), with or without hypothyroidism, is a common disease, particularly in females, and referral for endocrine consultation is not infrequent.

Discussion: In the last 15 years a remarkable amount of studies has been published that investigated the pathophysiology of women suffering from TAI, who undergo ART. Read More

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http://www.eurekaselect.com/159516/article
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http://dx.doi.org/10.2174/1871530318666180131103029DOI Listing
September 2018
16 Reads

Thyroid disorders in alemtuzumab-treated multiple sclerosis patients: a Belgian consensus on diagnosis and management.

Acta Neurol Belg 2018 Jun 25;118(2):153-159. Epub 2018 Jan 25.

Department of Endocrinology, Cliniques Universitaires St Luc, Brussels, Belgium.

This paper deals with thyroid disease that can occur after treatment with alemtuzumab (humanized monoclonal anti-CD52) for relapsing-remitting multiple sclerosis (MS). The 5-year incidence of thyroid adverse events in phase 3 clinical trials is up to 40.7%. Read More

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http://dx.doi.org/10.1007/s13760-018-0883-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971042PMC
June 2018
9 Reads

Association of Hysteroscopic vs Laparoscopic Sterilization With Procedural, Gynecological, and Medical Outcomes.

JAMA 2018 01;319(4):375-387

Department of Epidemiology of Health Products, French National Agency for Medicines and Health Products Safety (ANSM), Saint-Denis, France.

Importance: Safety of hysteroscopic sterilization has been recently questioned following reports of general symptoms such as allergy, tiredness, and depression in addition to associated gynecological results such as pelvic pain, perforation of fallopian tubes or uterus, and unwanted pregnancy.

Objective: To compare the risk of reported adverse events between hysteroscopic and laparoscopic sterilization.

Design, Setting, And Participants: French nationwide cohort study using the national hospital discharge database linked to the health insurance claims database. Read More

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http://dx.doi.org/10.1001/jama.2017.21269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833563PMC
January 2018
20 Reads

Exophthalmos in a young woman with no graves' disease - a case report of IgG4-related orbitopathy.

BMC Ophthalmol 2018 Jan 12;18(1). Epub 2018 Jan 12.

Division of Endocrinology, Department of Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei krt 98, Debrecen, 4032, Hungary.

Background: Immunoglobulin G4-related disease (IgG4-rd) is characterized by lymphoplasmacytic infiltration and tissue fibrosis. Orbital manifestations of IgG4-rd may include unilateral or bilateral proptosis, cicatricial extraocular muscle myopathy, orbital inflammation and pain which may mimic ophthalmic Graves' disease.

Case Presentation: A 25-year-old woman has been referred to the endocrinology clinic, 4 months after delivery, with suspected Graves' orbitopathy. Read More

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http://dx.doi.org/10.1186/s12886-018-0672-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766976PMC
January 2018
269 Reads

Impact of positive thyroid autoimmunity on pregnant women with subclinical hypothyroidism.

Endocrinol Diabetes Nutr 2018 Mar 6;65(3):150-155. Epub 2018 Jan 6.

Servicio de Endocrinología y Nutrición, Hospital Universitario Puerta del Mar, Departamento de Medicina, Facultad de Medicina, Universidad de Cádiz, Cádiz, España.

Background: The impact of subclinical hypothyroidism (SH) and thyroid autoimmunity on obstetric and perinatal complications continues to be a matter of interest and highly controversial.

Aim: To assess the impact of SH and autoimmunity in early pregnancy on the obstetric and perinatal complications in our population.

Material And Method: A retrospective cohort study in 435 women with SH (TSH ranging from 3. Read More

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http://dx.doi.org/10.1016/j.endinu.2017.11.013DOI Listing
March 2018
3 Reads

Autoimmune thyroid disease during pregnancy.

Lancet Diabetes Endocrinol 2018 07 12;6(7):575-586. Epub 2017 Dec 12.

Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, Boston MA, USA. Electronic address:

Understanding of changes in thyroid function and the consequences of thyroid disease during pregnancy has rapidly grown in the past two decades, and revised American Thyroid Association guidelines on this topic were published in 2017. This Review explores the association between thyroid autoimmunity and complications during and after pregnancy. Thyroid autoimmunity refers to the presence of antibodies to thyroperoxidase or thyroglobulin, or thyroid-stimulating hormone receptor antibodies (TRAbs), or a combination of these, and is present in up to 18% of pregnant women. Read More

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http://dx.doi.org/10.1016/S2213-8587(17)30402-3DOI Listing
July 2018
11 Reads

Dose Dependency and a Functional Cutoff for TPO-Antibody Positivity During Pregnancy.

J Clin Endocrinol Metab 2018 02;103(2):778-789

Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.

Objective: To investigate a dose dependency of thyroperoxidase antibody (TPOAb) concentrations in relation to thyroid function and premature delivery and define a population-based, pregnancy-specific, functional cutoff for TPOAb positivity.

Design: Individual participant meta-analysis of three prospective birth cohorts: the Amsterdam Born Children and their Development study, and the Holistic Approach to Pregnancy.

Setting: Population-based studies in the Netherlands (2002 to 2014). Read More

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https://academic.oup.com/jcem/article/103/2/778/4731739
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http://dx.doi.org/10.1210/jc.2017-01560DOI Listing
February 2018
16 Reads

An updated literature review on maternal-fetal and reproductive disorders of Toxoplasma gondii infection.

J Gynecol Obstet Hum Reprod 2018 Mar 8;47(3):133-140. Epub 2017 Dec 8.

Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, 48175-866 Tehran, Iran.

Background: Toxoplasma gondii infection is one of the most prevalent infectious disease with worldwide distribution. Congenital toxoplasmosis is annually responsible for 1.20 million disability-adjusted life years around the world, but often it is overlooked many countries. Read More

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http://dx.doi.org/10.1016/j.jogoh.2017.12.003DOI Listing
March 2018
12 Reads

[Thyroid screening in pregnancy - guideline in practice].

Vnitr Lek Fall 2017;63(9):555-560

Thyroid diseases may adversely affect the conception, maintain pregnancy. They increase the risk of complications in pregnancy and may have a negative effect on the fetus. Therefore it is necessary to capture thyroid diseases in the population of pregnant women, in the early stage of pregnancy. Read More

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February 2018
29 Reads

Benign thyroid disease in pregnancy: A state of the art review.

J Clin Transl Endocrinol 2016 Dec 23;6:37-49. Epub 2016 Nov 23.

Endocrinology and Diabetes, Salford Royal NHS Foundation Trust, Salford, Greater Manchester, UK.

Thyroid dysfunction is the commonest endocrine disorder in pregnancy apart from diabetes. Thyroid hormones are essential for fetal brain development in the embryonic phase. Maternal thyroid dysfunction during pregnancy may have significant adverse maternal and fetal outcomes such as preterm delivery, preeclampsia, miscarriage and low birth weight. Read More

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http://dx.doi.org/10.1016/j.jcte.2016.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644429PMC
December 2016
6 Reads

Characteristics of peripheral blood NK and NKT-like cells in euthyroid and subclinical hypothyroid women with thyroid autoimmunity experiencing reproductive failure.

J Reprod Immunol 2017 11 28;124:62-70. Epub 2017 Sep 28.

University of Pecs, Clinical Centre, 1st Department of Internal Medicine, 13 Ifjusag Street, 7624 Pecs, Hungary; University of Pecs, Centre of Excellence in Endocrinology, 13 Ifjusag Street, 7624 Pecs, Hungary.

Thyroid autoimmunity (TAI) appears to play a crucial role in female infertility, recurrent pregnancy loss and IVF failure. Thyroid autoantibodies against thyroid peroxidase and thyroglobulin have been shown to represent an independent risk factor for infertility and miscarriage. Moreover, thyroxin hormone administration reduces the risk of obstetrical complications in TAI positive women. Read More

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http://dx.doi.org/10.1016/j.jri.2017.09.008DOI Listing
November 2017
27 Reads

There is no association between the presence of anti-thyroid antibodies and increased reproductive loss in pregnant women after ART: a systematic review and meta-analysis.

JBRA Assist Reprod 2017 12 1;21(4):361-365. Epub 2017 Dec 1.

Reproductive Medicine Unit at Clinica Monteblanco.

Women submitted to ART treatments represent a select subgroup of individuals. Several studies have described the relationship between TAI and pregnancy outcomes as a result of ART, with contradictory results. The purpose of this systematic review was to determine the association between TAI and the risk of miscarriage in pregnancies resulting from ART. Read More

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http://dx.doi.org/10.5935/1518-0557.20170057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714606PMC
December 2017
26 Reads

Ketosis-prone diabetes and SLE co-presenting in an African lady with previous gestational diabetes.

Endocrinol Diabetes Metab Case Rep 2017 6;2017. Epub 2017 Oct 6.

Department of Diabetes and Endocrinology, Newham University Hospital, Barts Health NHS Trust, London, UK.

We describe the case of an African woman who was diagnosed with ketosis-prone diabetes with diabetes-associated autoantibodies, after being admitted for diabetic ketoacidosis (DKA) precipitated by her first presentation of systemic lupus erythematosus (SLE). She had a seven-year history of recurrent gestational diabetes (GDM) not requiring insulin therapy, with return to normoglycaemia after each pregnancy. This might have suggested that she had now developed type 2 diabetes (T2D). Read More

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http://dx.doi.org/10.1530/EDM-17-0086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633049PMC
October 2017
24 Reads

MECHANISMS IN ENDOCRINOLOGY: Maternal thyroid dysfunction during pregnancy and behavioural and psychiatric disorders of children: a systematic review.

Eur J Endocrinol 2017 Nov;177(5):R261-R273

Institute for Social Science Research, University of Queensland, Brisbane, Australia.

Background: Maternal thyroid dysfunction during pregnancy may lead to persistent neurodevelopmental disorders in the offspring appearing in later life. This study aimed to review the available evidence concerning the relationship between maternal thyroid status during pregnancy and offspring behavioural and psychiatric disorders.

Methods: Systematic electronic database searches were conducted using PubMed, Embase, PsycNET, Scopus, Google Scholar and Cochrane library. Read More

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http://dx.doi.org/10.1530/EJE-16-0860DOI Listing
November 2017
6 Reads

Severe selenium deficits in pregnant women irrespective of autoimmune thyroid disease in an area with marginal selenium intake.

J Trace Elem Med Biol 2017 Dec 4;44:186-191. Epub 2017 Aug 4.

Institute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.

Objectives: Selenium (Se) deficiency is related to an increased risk of preterm labor, miscarriage, preeclampsia, gestational diabetes, and other obstetric complications. As the Se status declines during pregnancy, we hypothesized that the decline may be exacerbated in women with autoimmune thyroid disease (AITD).

Material And Methods: Pregnant women (n=74; 30 [23-38] years) were consecutively recruited from the district of Warsaw, Poland, and divided into healthy subjects (HS, n=45), and women with a diagnosis of AITD (AITD, n=29). Read More

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http://dx.doi.org/10.1016/j.jtemb.2017.08.005DOI Listing
December 2017
30 Reads

Parity and Risk of Thyroid Autoimmunity Based on the NHANES (2001-2002, 2007-2008, 2009-2010, and 2011-2012).

J Clin Endocrinol Metab 2017 09;102(9):3437-3442

Division of Endocrinology and Metabolism, Harbor-University of California Los Angeles Medical Center, Torrance, California 90502.

Context: Autoimmune thyroid disease is more common in women than in men. Fetal microchimerism has been implicated as a potential explanation for this disparity.

Objective: The objective of this study was to evaluate the relationship between parity and thyroid autoimmunity in the US population. Read More

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http://dx.doi.org/10.1210/jc.2017-00290DOI Listing
September 2017
12 Reads