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Autoimmun Rev 2019 Jan 10. Epub 2019 Jan 10.

Department of Clinical and Experimental Medicine, University of Pisa, Via Savi 10, 56126 Pisa, Italy. Electronic address:

Graves' disease (GD) and autoimmune thyroiditis (AT) are the two main clinical presentations of AITD, and their clinical hallmarks are thyrotoxicosis and hypothyroidism, respectively. GD, and AT, can be associated with other organ specific, or systemic autoimmune diseases in the same patient. However discordant results have been reported in the literature about the possible associations. Read More

J Adv Pharm Technol Res 2018 Oct-Dec;9(4):158-161

Department of Endocrine, Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Hives is an erythematous and itchy disease that commonly affects the trunk and the organs. Acute urticaria is a common disease and affects about 10%-20% of the population during its lifetime. In patients with chronic urticaria, about 25%-30% of cases, antithyroid peroxidase (TPO) was detected and Hashimoto's disease was diagnosed. Read More

Kathmandu Univ Med J (KUMJ) 2018 Apr-Jun;16(62):161-165

Department of Biochemistry, BP Koirala Institute of Health Sciences, Dharan, Nepal.

Background Alopecia areata (AA) is one of the non-scarring alopecia. Its etiology has not been well established till date. The most convincing hypothesis is autoimmune process for its causation. Read More

Br J Dermatol 2019 Jan 10. Epub 2019 Jan 10.

Laboratory for Experimental Cardiology, Department of Biomedical Sciences, Panum Institute, DK-2200, Copenhagen N, Denmark.

Psoriasis has been associated with other autoimmune diseases, e.g. inflammatory bowel disease and autoimmune thyroid disease. Read More

Arch Endocrinol Metab 2018 ;62(6):609-614

Department of Endocrinology, CHU, Liège, Belgium.

Objective: The conversion of Hashimoto's thyroiditis (HT) to hyperthyroidism due to thyrotropin receptor antibodies is intriguing and considered rare. The contribution of TSH receptor blocking antibodies (TRAb), which may be stimulators (TSAb) or blockers (TBAb), is suspected. We describe clinical and biological variables in a series of patients switching from Hashimoto's thyroiditis to Grave's disease. Read More

J Immunother Cancer 2019 Jan 7;7(1). Epub 2019 Jan 7.

Department of Medicine, Division of Endocrinology, Diabetes and Metabolism and Center for Diabetes and Endocrine Research (CeDER), University of Toledo, College of Medicine and Life Sciences, 3000 Arlington Ave., M.S. 1186, Toledo, OH, 43614, USA.

Background: Thyroid cancer and thyroid autoimmunity are considered opposite extremes of immune-responses. However, several studies have suggested that thyroid cancer coexists with autoimmune thyroid diseases like Hashimoto Thyroiditis (HT) and Graves disease (GD). We have shown that the risk of developing thyroid cancer is higher in patients with a silent form of autoimmune thyroid disease -Euthyroid Hashimoto Thyroiditis-(EHT). Read More

Am J Reprod Immunol 2019 Jan 4:e13085. Epub 2019 Jan 4.

Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India.

Background & Objective: The modulatory role of prolactin in autoimmune regulation is well established. Hyperprolactinemia is often associated with autoimmune disease like systemic lupus erythematosus, autoimmune thyroid diseases, etc. The objective was to compare levels of direct and indirect autoimmune factors in different categories of hyperprolactinemia cases and predict the direction of association between hyperprolactinemia and autoimmune factors, if any. Read More

Clin Exp Med 2019 Jan 4. Epub 2019 Jan 4.

Immunoendocrinology, EndoMed, Bem tér 18/C., Debrecen, 4026, Hungary.

Graves' disease is an organ-specific autoimmune disease with hyperthyroidism, diffuse goiter and autoantibodies against TSH receptor, thyroid peroxidase (TPO) and/or thyroglobulin (Tg). Graves' hyperthyroidism is characterized by T dominance due to the conversion of T into T through type 1 and 2 deiodinase enzymes (DIO1, DIO2). Methimazole (MMI) and propylthiouracil (PTU) therapies inhibit thyroid hormone synthesis blocking the activity of deiodinase and TPO enzymes. Read More

Immunohorizons 2018 Jan;2(1):54-66

Department of Medicine and Microbiology, University of Missouri, Columbia, MO 65212.

CD40/CD40L interactions play a critical role in immunity and autoimmunity. In this study, we sought to understand the requirement for CD40 signaling in the programmed cell death-1 (PD-1) checkpoint and CD28 costimulatory pathways important for maintenance of peripheral tolerance. Blocking either pathway can result in loss of self-tolerance and development of autoimmunity. Read More

Diabetol Int 2018 May 9;9(2):108-112. Epub 2018 Mar 9.

Division of Clinical Nutrition and Metabolism, Wakayama Medical University, 811-1 Kimiidera, Wakayama, Wakayama 641-8509 Japan.

Both diabetes mellitus and thyroid diseases are very common in the fields of endocrinology and metabolism. Coexistence of diabetes mellitus and thyroid diseases are frequently experienced. However, higher prevalence of thyroid dysfunction in both type 1 and type 2 diabetes compared with non-diabetics have been reported. Read More

Clin Diabetes Endocrinol 2018 19;4:24. Epub 2018 Dec 19.

3Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Celiac disease (CD) is an autoimmune disorder related to the gluten and can be also associated with some other endocrine disorders such as type 1 diabetes and thyroid disease. Gluten exposure in CD may have especial role in developing other auto immune disorder.

Case Presentation: We reported two familial cases with celiac disease who were on a gluten free diet (GFD) and hyperthyroidism and type 1 diabetes were appeared following a regular diet. Read More

J Clin Neurosci 2019 Jan 24;59:179-184. Epub 2018 Oct 24.

Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, China; Department of Neurology, Jing'an District Centre Hospital of Shanghai, China. Electronic address:

To compare HLA typing between juvenile- and adult-onset myasthenia gravis (MG), we enrolled 101 children (age ≤12 years) and 168 adults (age ≥20 years) with MG. We excluded patients with histories of thymoma, thyroid disease, or other autoimmune disease. We selected 41 seronegative juvenile-onset patients with ocular symptoms only, and 41 seropositive adult-onset patients with generalized symptoms. Read More

Eur J Clin Invest 2018 Dec 27:e13065. Epub 2018 Dec 27.

Division of Endocrinology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.

Background: Dysregulation of the type 1 interferon (IFN)-related signaling pathway predisposes one to autoimmune diseases. Possible associations of single-nucleotide polymorphisms (SNPs) of Secreted phosphoprotein 1 (SPP1) and B lymphocyte kinase (BLK) of the type 1 IFN-related signaling pathway with autoimmune thyroid disease (AITD) in an ethnic Chinese (i.e. Read More

JAMA Oncol 2018 Dec 27. Epub 2018 Dec 27.

Department of Pulmonary Medicine, Sendai Kousei Hospital, Aoba-ku, Sendai, Miyagi, Japan.

Importance: Administration of anti-programmed cell death protein 1 (anti-PD-1) is now standard therapy in advanced non-small cell lung cancer (NSCLC). However, immune checkpoint inhibitors, including anti-PD-1, have not been assessed in patients with subclinical disease with advanced NSCLC, and no useful clinical biomarkers have been associated with immune-related adverse events (irAEs) among these patients treated with anti-PD-1.

Objective: To assess the safety and efficacy of anti-PD-1 treatment in patients with subclinical disease with advanced NSCLC and with or without preexisting autoimmune markers, including rheumatoid factor, antinuclear antibody, antithyroglobulin, and antithyroid peroxidase; and to assess potential clinical biomarkers that may be meaningfully and conveniently associated with clinical benefit or with irAEs following anti-PD-1 treatment. Read More

Eye (Lond) 2018 Dec 21. Epub 2018 Dec 21.

Cedars Sinai Medical Center Los Angeles and Zhongshen Ophthalmic Center, Guangzhou, China.

Thyroid eye disease is a disabling autoimmune disease associated with orbital inflammation and tissue remodeling which can result in significant proptosis, leading to visual alterations and is potentially sight threatening. Current evidence indicates that autoantibodies to the insulin-like growth factor 1 receptor (IGF-1R), along with the thyroid-stimulating hormone receptor (TSHR), mediate the pathogenesis in susceptible individuals. Teprotumumab, a monoclonal IGF-1R antagonist, has demonstrated previously in a 24 week, randomized, controlled trial to produce significant changes in composite outcomes of proptosis and clinical activity score as compared with placebo. Read More

J Hepatobiliary Pancreat Sci 2018 Dec 21. Epub 2018 Dec 21.

Department of Hepato-Biliary-Pancreatic and Gastrointestinal Surgery, International University of Health and Welfare, School of Medicine, Ichikawa, Japan.

Background: IgG4-related sclerosing cholangitis (IgG4-SC) is a distinct type of cholangitis frequently associated with autoimmune pancreatitis and currently recognized as a biliary manifestation of IgG4-related disease. Although clinical diagnostic criteria of IgG4-SC were established in 2012, differential diagnosis from primary sclerosing cholangitis and cholangiocarcinoma is sometimes difficult. Furthermore, no practical guidelines for IgG4-SC are available. Read More

Eur Thyroid J 2018 Nov 26;7(6):294-301. Epub 2018 Jul 26.

Department of Endocrinology, Carol Davila University of Medicine of Pharmacy, Bucharest, Romania.

Objectives: Pregnancy induces changes in thyroid function, and thyroid dysfunction during gestation is associated with adverse outcomes. We examined the management of subclinical hypothyroidism and chronic autoimmune thyroiditis in pregnancy among Italian and Romanian endocrinologists.

Methods: Members of the Associazione Medici Endocrinologi (AME) and Romanian Society of Endocrinology (RSE) were invited to participate in a web-based survey investigating the topic. Read More

Front Endocrinol (Lausanne) 2018 6;9:746. Epub 2018 Dec 6.

Department of Radiology, Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon, South Korea.

No previous studies have investigated the feasibility of magnetic resonance imaging (MRI) diagnosis for detecting incidental diffuse thyroid disease (DTD). This study investigated MRI features of normal thyroid parenchyma and incidental DTD. From January 2008 to December 2017, 387 patients underwent neck MRI in our hospital due to tumor/nodal staging ( = 137), lymphadenopathy ( = 122), inflammatory neck lesion ( = 85), congenital neck lesion ( = 12), and patient request ( = 31). Read More

Medicine (Baltimore) 2018 Dec;97(51):e13486

Department of Endocrinology, the People's Hospital of China Three Gorges University & The First People's Hospital of Yichang, Yichang, Hubei Province, China.

Rationale: Insulin autoimmune syndrome (IAS) is a rare endocrine disease characterized by repeated fasting hypoglycemia or episodes of hypoglycemia late after meals, elevated serum insulin, and positivity for insulin autoantibody (IAA) or insulin receptor antibody (IRA). We summarize the clinical manifestations and treatment experiences of 3 patients with IAS.

Patient Concerns: One patient with >20-year history of type 2 diabetes mellitus had irregular episodes of hypoglycemia 2 years of after treatment with insulin. Read More

Acta Clin Belg 2018 Dec 20:1-5. Epub 2018 Dec 20.

a Department of Oncology and Nuclear Medicine , University Hospital Center "Sestre Milosrdnice" , Zagreb , Croatia.

Objectives: Hashimoto's thyroiditis (HT) is a common autoimmune disease. Available data show that HT develops as a result of interaction between genetic susceptibility and environmental factors, but the exact pathogenesis of the disease is not yet fully understood. The aim of this investigation is to evaluate the potential relationship between family history of HT and the development of HT. Read More

Reumatismo 2018 Dec 20;70(4):268-269. Epub 2018 Dec 20.

Clinica Reumatologica, Policlinico San Martino, Genova.

Hashimoto's encephalopathy (HE) is an autoimmune form of encephalopathy, associated with autoimmune thyroiditis. Its prevalence is estimated to be 2:100,000. HE is characterized by behavioral changes, mental confusion, dysarthria, ataxia, psychosis, paranoia, convulsions, hallucinations, headache and hyperthermia. Read More

Arch Gynecol Obstet 2018 Dec 19. Epub 2018 Dec 19.

Department of Medical, Surgical and Experimental Sciences, University of Sassari, 07100, Sassari, Italy.

Purpose: To review the literature on thyroid function and thyroid disorders during pregnancy.

Methods: A detailed literature research on MEDLINE, Cochrane library, EMBASE, NLH, ClinicalTrials.gov, and Google Scholar databases was done up to January 2018 with restriction to English language about articles regarding thyroid diseases and pregnancy. Read More

Endocr J 2018 Dec 18. Epub 2018 Dec 18.

Department of Diabetes, Endocrinology and Metabolism, Division of Internal Medicine, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.

There is a great deal of research interest regarding the underlying causes of slightly elevated TSH values in patients with subclinical hypothyroidism (SH) without abnormal findings on ultrasonography or anti-thyroid antibodies. Twelve infertile women with thyroglobulin antibody (TGAb) and thyroid peroxidase antibody (TPOAb)-negative nongoitrous SH were referred to our department of endocrinology between September 2007 and September 2015. None had been diagnosed with autoimmune thyroid disease or had any possible causes of SH. Read More

Interact J Med Res 2018 Dec 19;7(2):e18. Epub 2018 Dec 19.

Division of Gastroenterology and Hepatology, Indiana University, Indianapolis, IN, United States.

Background: Concurrent autoimmune illnesses contribute to increased medical burden and reduced quality of life in patients with autoimmune hepatitis (AIH). The frequency of coexisting autoimmune conditions among North American patients with AIH and their families remains incomplete. Challenges associated with disease capture in the electronic medical record, high study costs, and geographic spread of patients are formidable barriers to understanding the extent of concurrent autoimmune conditions in these groups. Read More

Clin Exp Immunol 2018 Dec 19. Epub 2018 Dec 19.

Thyroid Autoimmune Disease Unit, Cedars-Sinai Research Institute and UCLA School of Medicine, Los Angeles, CA, USA.

NOD.H2 mice are the most commonly used model for human autoimmune thyroiditis. Because thyroid autoimmunity develops slowly (over months), NOD. Read More

Eur J Gastroenterol Hepatol 2018 Dec 17. Epub 2018 Dec 17.

Departments of Gastroenterology and Hepatology.

Background: There is no literature on risk factors for incidentally found angiodysplasias. In clinical practice, endoscopists may defer treatment owing to uncertainty about a causal role of any found angiodysplasia and overt or occult bleeding. The objective is to identify risk factors that distinguish incidental angiodysplasias from angiodysplasias that are the cause of symptomatic bleeding. Read More

Acta Biomed 2018 Dec 17;89(8-S):100-103. Epub 2018 Dec 17.

Endoscopy Unit, Departement of Surgery, ULSS7-Pedemontana, Santorso Hospital, Santorso (VI), Italy.

Autoimmune diseases, characterized by an alteration of the immune system which results in a loss of tolerance to self antigens often coexist in the same patient. Autoimmune atrophic gastritis, characterized by the development of antibodies agains parietal cells and against intrinsic factor, leads to mucosal destruction that affects primarily the corpus and fundus of the stomach. Autoimmune atrophic gastritis is frequently found in association with thyroid disease, including Hashimoto's thyroiditis, and with type 1 diabetes mellitus, Other autoimmune conditions that have been described in association with autoimmune atrophic gastritis are Addison's disease, chronic spontaneous urticaria, myasthenia gravis, vitiligo, and perioral cutaneous autoimmune conditions, especially erosive oral lichen planus. Read More

Acta Biomed 2018 Dec 17;89(9-S):11-16. Epub 2018 Dec 17.

Gastroenterology and Endoscopy Unit, Department of Medicine and Surgery, University of Parma, Parma, Italy.

Chronic autoimmune thyroid disease or Hashimoto thyroiditis (HT) and Graves-Basedow disease (GD) are the main autoimmune thyroid diseases in pediatric age. Both are characterized by the production of anti-thyroid antibodies, by an infiltration of autoreactive B and T lymphocytes into the thyroid parenchyma and by alterations in thyroid function (hyperthyroidism in GD, normal function or subclinical hypothyroidism in HT with possible evolution towards manifest hypothyroidism). Celiac disease (CD) is a systemic autoimmune disease caused by gluten ingestion in genetically predisposed subjects, its prevalence is around 1% in Western Countries. Read More

Br J Dermatol 2018 Dec 18. Epub 2018 Dec 18.

Siaal Research Center for Family Medicine and Primary Care, Division of Community Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Background: Chronic urticaria (CU) carries many risk factors for osteoporosis, but data on the relation between CU and osteoporosis are lacking.

Objective: To evaluate the association between CU and osteoporosis in a large community-based study.

Methods: A nationwide observational longitudinal cohort study was conducted. Read More

Singapore Med J 2018 Dec 17. Epub 2018 Dec 17.

Department of Paediatrics, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.

Introduction: Endocrine dysfunction due to iron overload secondary to frequent blood transfusions is a common complication in children with transfusion-dependent thalassaemia (TDT). We ascertained the prevalence of endocrine dysfunction in children with TDT seen in a hospital setting in Malaysia.

Methods: We reviewed all patients with TDT who had ≥ 8 blood transfusions per year. Read More

Dev Med Child Neurol 2018 Dec 12. Epub 2018 Dec 12.

Department of Pediatrics, Duke University Medical Center, Durham, NC, USA.

Down syndrome disintegrative disorder (DSDD) is an increasingly identified condition characterized by cognitive decline, autistic characteristics, insomnia, catatonia, and psychosis in adolescents and young adults with Down syndrome. Previously we reported a higher rate of autoimmune thyroid disease in these patients compared with unaffected individuals with Down syndrome. We therefore hypothesized DSDD may in some cases be immune-mediated. Read More

Oncol Rep 2018 Dec 5;40(6):3879-3889. Epub 2018 Oct 5.

College of Pharmacy, University of Cincinnati Academic Health Center, Cincinnati, OH 45267‑0004, USA.

The aberrant processing of biomolecules by cancer cells may give rise to autoimmune phenomena. The metastasis gene osteopontin is alternatively spliced only in transformed cells, and the variants promote tumor progression. They may also serve as tumor‑associated antigens, and their neutralization by autoantibodies could favorably affect prognosis. Read More

Orbit 2018 Dec 7:1-6. Epub 2018 Dec 7.

b Professor in Endocrinology , St George Public Hospital , Kogarah , NSW , Australia.

Paraneoplastic syndrome is a rare but reversible cause of non-thyroid-related extraocular muscle enlargement. We present a 71-year-old lady with diplopia, restricted eye movements, suppressed thyroid-stimulating hormone and enlargement of all extraocular muscles while on thyroxine replacement for hypothyroidism. She had distant history of metastatic breast cancer treated with chemotherapy, surgical resection and tamoxifen. Read More

J Endocrinol Invest 2018 Dec 8. Epub 2018 Dec 8.

Department of Emergency, Jinshan Hospital of Fudan University, No. 1508 Longhang Road, Jinshan District, Shanghai, 201508, China.

Purpose: Autoimmune thyroid diseases (AITDs) are chronic organ-specific autoimmune disorders, predominantly including Graves' disease (GD), and Hashimoto's thyroiditis (HT). This study aimed to investigate whether single-nucleotide polymorphisms (SNPs) in MAGI2 and MAGI3 gene contributed to the etiology of AITDs.

Methods: We conducted a case-control study including 1001 patients with AITDs (625 GD, 376 HT) and 846 healthy controls. Read More

Rom J Morphol Embryol 2018 ;59(3):755-762

Department of Research Methodology, University of Medicine and Pharmacy of Craiova, Romania;

Multiple sclerosis (MS) is a complex chronic neurodegenerative disease that involves an abnormal autoimmune response directed against the brain, nerves and spinal cord; it is considered the most frequent cause of neurological disability, because MS-associated inflammatory lesions can affect a wide range of systems to a varying degree and may cause a plethora of neurological comorbidities and symptoms. The symptoms are quite variable from patient to patient and depend on the spatial distribution of the central nervous system (CNS) lesions, but usually involve sensory disturbances, cognitive deficits, unilateral vision loss, bladder dysfunction, ataxia, fatigue, double vision, weakness of the limbs and intestinal disorders. Experimental autoimmune encephalitis (EAE) mouse model reproduces the pathological features of the human disease, and is a widely used model used for studying the pathology and different treatment options in the preclinical stage. Read More

Leuk Res Rep 2019 22;11:5-7. Epub 2018 Nov 22.

Division of Hematology, Japanese Red Cross Society Wakayama Medical Center, Wakayama, Wakayama, Japan.

Thyroid dysfunction is an important issue in patients receiving autologous and allogenic hematopoietic stem cell transplantation (HSCT). However, the exact mechanisms underlying thyrotoxicosis secondary to HSCT remain unclear. The present case exhibited a reversed imbalance in helper/suppressor T-cell populations and B-cell dysregulation for a long time after transplantation, and the reactivation of cytomegalovirus may have been associated with the development of clinical hyperthyroidism. Read More

Eye (Lond) 2018 Dec 7. Epub 2018 Dec 7.

Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, 200011, Shanghai, China.

Thyroid-associated ophthalmoapthy (TAO) is the most common orbital disease. As an autoimmune disorder, it is caused by self-reactive lymphocytes that escape immune tolerance, but the mechanism is not fully understood. The basic process of TAO is the infiltration of immune cells in orbital tissues, the activation of orbital fibroblasts (OFs), and the proliferation and differentiation of OFs and lymphocytes. Read More

BMC Pregnancy Childbirth 2018 Dec 3;18(1):468. Epub 2018 Dec 3.

Department of Endocrinology and Metabolism, The Endocrine Institute and The Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Hospital of China Medical University, 155 Nanjing Bei Street, Shenyang, Liaoning, 110001, People's Republic of China.

Background: Resistance to thyroid hormone beta (RTHβ) results in symptoms of both increased and decreased thyroid hormone action. The effect of thyroid hormone changes in different types of autoimmune thyroid disease (AITD) in RTHβ is dynamic.

Case Presentation: A 25-year-old Asian female had a RTHβ Y321C mutation with Hashimoto's thyroiditis and type 2 diabetes mellitus. Read More

Orv Hetil 2018 Dec;159(49):2065-2072

I. Gyermekgyógyászati Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Bókay J. u. 53., 1083.

Experimental and clinical data suggest a complex interaction between the endocrine and immune systems. However, only few epidemiological studies are available dealing with endocrine complications in different types of primary immunodeficiency diseases. It is well documented that there is a close association between immunodeficiency syndromes and the development of autoimmune disorders. Read More

J Clin Endocrinol Metab 2018 Dec 5. Epub 2018 Dec 5.

Molecular Thyroid Research Laboratory, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany.

Context: The Major Histocompatibility Complex (MHC) strongly contributes to the development of polyglandular autoimmunity (PGA).

Objective: To evaluate the impact of gender on human leukocyte antigen (HLA) association with PGA for the first time.

Design: Cross-sectional immunogenetic study. Read More

Eur J Endocrinol 2019 Feb;180(2):135-144

Department of Internal Medicine, Section Endocrinology & Metabolism.

Introduction The association between type 1 diabetes (T1D) and other auto-immune diseases is well known. However, a quantitative overview of all associated auto-immune diseases and their prevalence in T1D is lacking. Methods We searched PubMed, Web of Science, EMBASE and Cochrane library in September 2018 to identify relevant articles about the prevalence of the following associated auto-immune diseases in T1D cohorts: auto-immune thyroid disease, celiac disease, gastric autoimmunity including pernicious anemia, vitiligo and adrenal gland insufficiency. Read More

Rev Endocr Metab Disord 2018 Dec 3. Epub 2018 Dec 3.

Department of Clinical and Experimental Medicine, University of Pisa, School of Medicine, Via Savi, 10, I-56126, Pisa, Italy.

Myo-inositol (Myo-Ins) plays an important role in thyroid function and autoimmunity. Myo-Ins is the precursor for the synthesis of phosphoinositides, which takes part in the phosphatidylinositol (PtdIns) signal transduction pathway, and plays a decisive role in several cellular processes. In the thyroid cells, PtdIns is involved in the intracellular thyroid-stimulating hormone (TSH) signaling, via Phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P3) (PIP-3). Read More

Anticancer Res 2018 Dec;38(12):6847-6853

Department of Histology and Embryology, Medical University of Wroclaw, Wroclaw, Poland.

Background/aim: The expression of metallothionein I/II (MT-I/II) was examined in thyroids of Graves' disease (GD) and nodular goiter (NG) patients to determine its role as a potential marker of proliferation and autoimmune inflammation in the thyroid.

Patients And Methods: MT-I/II and Ki-67 antigen expression was studied using immunohistochemistry in 72 GD and 24 NG patients.

Results: MT-I/II expression was noted in the cytoplasm and nuclei of thyrocytes of GD and NG patients. Read More

Horm Metab Res 2018 Dec 5;50(12):837-839. Epub 2018 Dec 5.

Division for Specific Endocrinology, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany.

Biomed Res Int 2018 1;2018:9856843. Epub 2018 Nov 1.

Division of Dermatology, Department of Internal Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Background: Chronic spontaneous urticaria (CSU) is autoimmune in nature and associated with thyroid autoimmunity (TA), but evidence on autoimmunity in relation to CSU progression and prognosis is limited. We evaluated whether TA and autoimmunity in CSU are correlated with disease severity, therapeutic response, and time to remission and establish an association between CSU characteristics linked to thyroid autoantibody.

Methods: Medical records of patients diagnosed with urticaria attending outpatient dermatology clinic at a university-based hospital from 2013 to 2017 were retrospectively reviewed. Read More

Zhejiang Da Xue Xue Bao Yi Xue Ban 2018 Feb;47(4):435-440

Department of Rheumatism and Immunology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.

Systemic lupus erythematosus (SLE) is a multiorgan-involved autoimmune disease, and it can overlap organ-specific autoimmune diseases such as autoimmune thyroid diseases, autoimmune hepatitis and inflammatory bowel disease. There may be some association between SLE and these autoimmune diseases, such as common immunological and genetic basis, but the pathogenic mechanism is still unclear. This review focuses on current knowledge regarding the prevalence and possible pathogenesis of SLE overlapping the above three autoimmune diseases. Read More

World J Clin Cases 2018 Nov;6(14):854-861

Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.

Pretibial myxedema (PTM), an uncommon manifestation of Graves' disease (GD), is a local autoimmune reaction in the cutaneous tissue. The treatment of PTM is a clinical challenge. We herein report on a patient with PTM who achieved complete remission by multipoint subcutaneous injections of a long-acting glucocorticoid and topical glucocorticoid ointment application for a self-controlled study. Read More

Case Rep Endocrinol 2018 30;2018:3210317. Epub 2018 Oct 30.

Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori 036-8562, Japan.

Subacute thyroiditis is an inflammatory disorder of the thyroid. Graves' disease is an autoimmune thyroid disease in which thyroid hormones are overproduced. Here we present a rare case of thyrotoxicosis due to the simultaneous occurrence of both diseases. Read More

Eye (Lond) 2018 Nov 29. Epub 2018 Nov 29.

Thyroid Eye Disease Service, Department of Ophthalmology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

Alemtuzumab-a monoclonal antibody targeting the CD52 glycoprotein expressed by most mature leucocytes-effectively decreases relapse rate and disability progression in early, relapsing-remitting multiple sclerosis (MS). However, secondary autoimmune disorders complicate therapy in nearly 50% of treated patients, with Graves' disease being the most common. Rarely, thyroid eye disease (TED) ensues; only seven such cases have been reported. Read More

Horm Res Paediatr 2018 29;90(4):266-269. Epub 2018 Nov 29.

Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

Background: Variance between current American Diabetes Association (ADA) and International Society for Pediatric and Adolescent Diabetes (ISPAD) guidelines and in clinical practice exists for the use of thyroid antibody and thyroid function screening in pediatric patients with new-onset type 1 diabetes (T1D).

Methods: North American Pediatric Endocrine Society (PES) members were surveyed regarding their thyroid screening practices of euthyroid youth with T1D. An institutional analysis of the ability of antithyroid peroxidase (aTPO) and antithyroglobulin antibodies (aTG) to predict the subsequent use of levothyroxine was performed. Read More