16,878 results match your criteria Autoimmune Thyroid Disease & Pregnancy


Gluten intake and risk of thyroid peroxidase autoantibodies in the Diabetes Autoimmunity Study In the Young (DAISY).

Endocrine 2020 Jul 10. Epub 2020 Jul 10.

Department of Epidemiology, Colorado School of Public Health, Aurora, CO, USA.

Purpose: Autoimmune diseases co-occur, perhaps due to common risk factors. The age at gluten introduction and gluten intake in early childhood has been associated with the autoimmunity preceding celiac disease (CD) and type-1 diabetes (T1D). We explored their associations with the development of thyroid autoimmunity. Read More

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http://dx.doi.org/10.1007/s12020-020-02412-3DOI Listing

Thyroid dysfunction following pregnancy and implications for breastfeeding.

Best Pract Res Clin Endocrinol Metab 2020 Jun 20:101438. Epub 2020 Jun 20.

Division of Maternal Medicine, Center for Maternal-Fetal-Neonatal and Reproductive Medicine, National Center for Child Health and Development, 2-10-1 Okura, Setagayaku, Tokyo, 1578535, Japan. Electronic address:

Subclinical autoimmune thyroiditis exacerbates after delivery through immune rebound mechanisms and results in 5 types of thyroid dysfunction. The prevalence of postpartum thyroid dysfunction is around 5% in mothers in the general population. Typically, an exacerbation induces destructive thyrotoxicosis followed by transient hypothyroidism, known as postpartum thyroiditis. Read More

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http://dx.doi.org/10.1016/j.beem.2020.101438DOI Listing

Management of neonates born to mothers with thyroid dysfunction, and points for attention during pregnancy.

Best Pract Res Clin Endocrinol Metab 2020 Jun 18:101437. Epub 2020 Jun 18.

Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Pediatric Endocrinology, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands. Electronic address:

Thyroid hormone (TH) is indispensable for normal embryonic and fetal development. Throughout gestation TH is provided by the mother via the placenta, later in pregnancy the fetal thyroid gland makes an increasing contribution. Maternal thyroid dysfunction, resulting in lower or higher than normal (maternal) TH levels and transfer to the embryo/fetus, can disturb normal early development. Read More

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http://dx.doi.org/10.1016/j.beem.2020.101437DOI Listing

Analysis of Hashimoto's thyroiditis on fine needle aspiration samples by MALDI-Imaging.

Biochim Biophys Acta Proteins Proteom 2020 Jul 6:140481. Epub 2020 Jul 6.

Pathology, Department of Medicine and Surgery, University of Milano-Bicocca, San Gerardo Hospital, ASST, Monza, Italy. Electronic address:

Matrix-Assisted Laser Desorption/Ionization (MALDI)- Mass Spectrometry imaging (MSI) has been applied in various diseases aimed to biomarkers discovery. In this study diagnosis and prognosis of Hashimoto Thyroiditis (HT) in cytopathology by MALDI-MSI has been investigated. Specimens from a routine series of subjects who underwent UltraSound-guided thyroid Fine Needle Aspirations (FNAs) were used. Read More

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http://dx.doi.org/10.1016/j.bbapap.2020.140481DOI Listing

Sudden-onset Encephalopathy: Do not ignore the Possibility of Hashimoto's Encephalopathy.

Neurol India 2020 May-Jun;68(3):681-683

King Fahd Hospital, Department of Neurology, Imam Abdulrahman Binfaisal University, Dammam, Saudi Arabia.

Hashimoto's encephalopathy (HE) is an uncommon neurological disorder of unknown etiology, found in association with thyroid autoimmunity, mostly uncommon in males. The disease occurs primarily in the fifth decade of life and may occur in two forms; a sudden vasculitic type or a progressive subacute type associated with cognitive dysfunction, confusion, and memory loss. We report a case of a 51-year-old Sri Lankan gentleman with no comorbidities who was presented with one episode of the generalized tonic- clonic seizure (GTCs) followed by prolonged agitation and disorientation. Read More

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http://dx.doi.org/10.4103/0028-3886.289015DOI Listing

Roles of Thyroid Hormones, Mast Cells, and Inflammatory Mediators in the Initiation and Progression of Autoimmune Thyroid Diseases.

Int Arch Allergy Immunol 2020 Jul 8:1-12. Epub 2020 Jul 8.

Department of Clinical Immunology and Allergy Sechenov, First Moscow State Medical University, Moscow, Russian Federation.

Background: Interrelation between thyrocytes and immunocytes has been established. However, the roles of mast cells and thyroid hormones in the triggering mechanism of thyroid autoimmune processes have been insufficiently investigated. This study evaluated the role of thyroid hormones and mast cells in the mechanisms of losing tolerance to thyroid autoantigens. Read More

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http://dx.doi.org/10.1159/000508937DOI Listing

Sjögren Syndrome and Cancer.

Rheum Dis Clin North Am 2020 Aug;46(3):513-532

Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Departments of Medicine and Pathology, University of Oklahoma Health Sciences Center, MS 38, 825 Northeast 13th Street, Oklahoma City, OK 73104, USA; US Department of Veterans Affairs, Oklahoma City, OK, USA. Electronic address:

The association between malignancy and rheumatic diseases has been demonstrated in a multitude of studies. Little is understood regarding the pathogenesis of rheumatic and musculoskeletal diseases in association with malignancy. There is strong evidence regarding the association between Sjögren syndrome and lymphoma as well as risk factors for development of lymphoma in these patients. Read More

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http://dx.doi.org/10.1016/j.rdc.2020.05.004DOI Listing

Thyroid peroxidase antibodies are common in children with HLA-conferred susceptibility to type 1 diabetes, but are weakly associated with thyroid function.

J Pediatr Endocrinol Metab 2020 Jul 7. Epub 2020 Jul 7.

Department of Paediatrics, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia.

Background The need for screening for autoimmune thyroid disease in children who have HLA-conferred susceptibility to type 1 diabetes (T1D), but have not yet been diagnosed with T1D, has not been thoroughly studied. The aim of this study was to describe the prevalence of positive thyroid peroxidase antibodies and its effect on thyroid function in children with genetic susceptibility to T1D as well as to describe the association between thyroid autoimmunity and HLA-DQ genotypes. Methods Cross-sectional study in 223 children (112 boys) aged 7. Read More

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http://dx.doi.org/10.1515/jpem-2019-0512DOI Listing

Dysregulation of Circulating FGF19 and Bile Acids in Primary Biliary Cholangitis-Autoimmune Hepatitis Overlap Syndrome.

Biomed Res Int 2020 11;2020:1934541. Epub 2020 Jun 11.

Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China.

Background: Primary biliary cholangitis-autoimmune hepatitis overlap syndrome (PBC-AIH OS), which exhibits features between autoimmune hepatitis and cholestasis, is a common condition and usually shows a progressive course toward cirrhosis and liver failure without adequate treatment. Synthesis of bile acids (BAs) plays an important role in liver injury in cholestasis, and the process is regulated by fibroblast growth factor 19 (FGF19). The overall role of circulating FGF19 in BA synthesis and PBC-AIH OS requires further investigation. Read More

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http://dx.doi.org/10.1155/2020/1934541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306076PMC

The roles of PPARγ and its agonists in autoimmune diseases: A comprehensive review.

J Autoimmun 2020 Jul 1:102510. Epub 2020 Jul 1.

Department of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenetics, Changsha, Hunan, 410011, PR China. Electronic address:

Autoimmune diseases are common diseases of the immune system that are characterized by the loss of self-tolerance and the production of autoantibodies; the breakdown of immune tolerance and the prolonged inflammatory reaction are undisputedly core steps in the initiation and maintenance of autoimmunity. Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors that belong to the nuclear hormone receptor family and act as ligand-activated transcription factors. There are three different isotypes of PPARs: PPARα, PPARγ, and PPARβ/δ. Read More

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http://dx.doi.org/10.1016/j.jaut.2020.102510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327470PMC

Serum concentrations of TNF-α and its soluble receptors in Graves' disease.

Endocr Connect 2020 Jul 1. Epub 2020 Jul 1.

D Zhang, Clinical Medicine Research Center, Nantong City No 1 People's Hospital and Second Affiliated Hospital of Nantong University, Nantong, China.

Graves' disease (GD), an organ-specific autoimmune disease, is the most common cause of hyperthyroidism. Tumour necrosis factor-alpha (TNF-α) exhibits immunological and metabolic activities involved in the induction and maintenance of immune responses. We attempted to evaluate the relationship between GD and serum TNF-α and its soluble receptors (sTNFRs), soluble tumour necrosis factor receptor 1 and 2 (sTNF-R1 and sTNF-R2). Read More

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http://dx.doi.org/10.1530/EC-20-0162DOI Listing

Graves' disease.

Nat Rev Dis Primers 2020 Jul 2;6(1):52. Epub 2020 Jul 2.

Department of Medicine I, Johannes Gutenberg University Medical Centre, Mainz, Germany.

Graves' disease (GD) is an autoimmune disease that primarily affects the thyroid gland. It is the most common cause of hyperthyroidism and occurs at all ages but especially in women of reproductive age. Graves' hyperthyroidism is caused by autoantibodies to the thyroid-stimulating hormone receptor (TSHR) that act as agonists and induce excessive thyroid hormone secretion, releasing the thyroid gland from pituitary control. Read More

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http://dx.doi.org/10.1038/s41572-020-0184-yDOI Listing

Identification of Enterococcus faecalis in a patient with urinary-tract infection based on metagenomic next-generation sequencing: a case report.

BMC Infect Dis 2020 Jul 2;20(1):467. Epub 2020 Jul 2.

Department of Intensive Care Medicine, The Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, 200233, China.

Background: Urinary tract infection (UTI) caused by various pathogenic microorganisms is ubiquitous in the parts of the urinary system such as kidney, ureter, bladder, and urethra. Currently, clinical detection of UTI is mainly focused on urine culture; however, the diagnostic value of urine culture remains limited due to the time-consuming procedure and low detection rate, especially in patients who have used antibiotics. Generally, treatment for UTI relies on empirical medication rather than pathogen diagnosis, which leads to the inappropriate use of antimicrobial agents and a significant increase in resistant strains. Read More

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http://dx.doi.org/10.1186/s12879-020-05179-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330266PMC

Alemtuzumab-related thyroid disease in people with multiple sclerosis is associated with age and brainstem phenotype at disease onset.

Mult Scler J Exp Transl Clin 2020 Apr-Jun;6(2):2055217320933928. Epub 2020 Jun 18.

Department of Neurology, St. Vincent's University Hospital, Dublin, Ireland.

Background: Autoimmune thyroid disease (AITD) occurs in 40%-50% of alemtuzumab-treated persons with multiple sclerosis (pwMS), most of whom will develop Graves' Disease (GD).

Objective: To explore contributory factors for alemtuzumab-related AITD in pwMS.

Methods: A retrospective patient chart review was performed. Read More

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http://dx.doi.org/10.1177/2055217320933928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307483PMC

Identification of Key Differentially Expressed Transcription Factors in Glioblastoma.

J Oncol 2020 15;2020:9235101. Epub 2020 Jun 15.

Department of Neurosurgery, The Fifth Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530022, China.

Glioblastoma (GBM) is the most frequent malignant brain tumor in adults. Our study focused on uncovering differentially expressed genes (DEGs) and their methylation in order to identify novel diagnostic biomarkers and potential treatment targets. Using GBM RNA-sequencing data from The Cancer Genome Atlas (TCGA) database, DEGs between GBM samples and paracancer tissue samples were analyzed. Read More

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http://dx.doi.org/10.1155/2020/9235101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313158PMC

The Association Between Foxp3 Polymorphisms and Risk of Graves' Disease: A Systematic Review and Meta-Analysis of Observational Studies.

Front Endocrinol (Lausanne) 2020 16;11:392. Epub 2020 Jun 16.

Department of Orthopedics, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.

This systematic review and meta-analysis was carried out with the aim of investigating the relationship between Foxp3 polymorphisms (rs3761547, r3761548, and rs3761549) and the risk of Graves' disease (GD). Four online database including PubMed, EMBASE, ISI Web of Science, and CNKI were searched to identify observational studies that evaluated the association between Foxp3 polymorphisms and risk of GD. The strength of associations was indicated as odds ratio (OR) and corresponding 95% confidence interval (95%CI) under the allelic model. Read More

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http://dx.doi.org/10.3389/fendo.2020.00392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308555PMC

The change in the clinical presentation of Graves' disease: a 30 years retrospective survey in an academic Brazilian tertiary center.

Arch Endocrinol Metab 2020 Jun 29. Epub 2020 Jun 29.

Endocrinologia e Metabolismo, Hospital da Pontifícia Universidade Católica de Campinas (PUC-Campinas), Campinas,SP, Brasil.

Objective: Graves' disease (GD) is the main cause of hyperthyroidism among adults. It is an autoimmune condition classically marked by the Merserburg Triad (goiter, thyrotoxicosis, and orbitopathy), but the change in presentation of GD over time has rarely been studied. To determine changes in the clinical presentation of patients with GD in the last 30 years. Read More

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http://dx.doi.org/10.20945/2359-3997000000265DOI Listing

Clinicopathological characterization and prognostic implication of FOXP3 and CK19 expression in papillary thyroid carcinoma and concomitant Hashimoto's thyroiditis.

Sci Rep 2020 Jun 30;10(1):10651. Epub 2020 Jun 30.

Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Papillary thyroid carcinoma (PTC) is considered the most prevalent thyroid malignancy. The association between Hashimoto's thyroiditis (HT) and PTC is still unclear. We aimed to examine the clinicopathological impact of immunohistochemical staining of FOXP3 and Cytokeratin 19 in PTC and concomitant HT and their correlation with patients' outcome and survival. Read More

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http://dx.doi.org/10.1038/s41598-020-67615-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326975PMC

A case of autoimmune polyendocrine syndrome type 3 (APS-3) complicated with anti-N-methyl-D-aspartic acid-receptor (NMDA-R) encephalitis.

J Diabetes Investig 2020 Jun 30. Epub 2020 Jun 30.

First Department of Internal Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan.

Anti-N-methyl-D-aspartate receptor (NMDA-R) encephalitis is an autoimmune disorder in which autoantibodies in the limbic system bind to GluN1 subunits of NMDA-Rs in the brain. We report a rare case of autoimmune polyendocrine syndrome type 3 (APS-3) complicated by anti-NMDA-R encephalitis. After hospitalization for type 1 diabetes the 39-year-old patient developed various schizophreniform symptoms and seizures following cold-like symptoms. Read More

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http://dx.doi.org/10.1111/jdi.13341DOI Listing

[Relationship of the ovarian reserve with autoimmune thyroid diseases in the reproductive period].

Ter Arkh 2019 Oct 15;91(10):14-18. Epub 2019 Oct 15.

Endocrinology Research Centre.

Aim: To compare ovarian reserve in healthy women of reproductive age - carriers of antithyroid antibodies (ATA) and in healthy women of reproductive age negative for ATA.

Materials And Methods: 70 healthy women of young reproductive age in the state of euthyroidism (from 18 to 38 years old) were examined. Participants were divided into equal groups (n=35) depending on the status of the presence of antithyroid antibodies (AT-TPO, AT-TG). Read More

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http://dx.doi.org/10.26442/00403660.2019.10.000095DOI Listing
October 2019

The Epidemiology of Celiac Disease in the General Population and High-Risk Groups in Arab Countries: A Systematic Review.

Biomed Res Int 2020 3;2020:6865917. Epub 2020 Jun 3.

King Abdulaziz Medical City, National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

Background And Aims: Celiac disease (CD) is possibly the most common autoimmune disorder, which may lead to dietary problems in the Arab region. This paper is aimed at exploring the epidemiology of the celiac disease in Arab countries, including its prevalence, associated risk factors, and clinical patterns.

Methods: An extensive search of the literature was conducted from electronic databases such as PubMed, Embase, and Google Scholar. Read More

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http://dx.doi.org/10.1155/2020/6865917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292982PMC

Anticancer Drug-induced Thyroid Dysfunction.

Eur Endocrinol 2020 Apr 4;16(1):32-39. Epub 2020 Feb 4.

Bharti Hospital, Karnal, India.

Cancer immunotherapy and targeted therapy, though less toxic than conventional chemotherapy, can increase the risk of thyroid dysfunction. Immune checkpoint inhibitors render the cancer cells susceptible to immune destruction, but also predispose to autoimmune disorders like primary hypothyroidism as well as central hypothyroidism secondary to hypophysitis. Tyrosine kinase inhibitors act by blocking vascular endothelial growth factor receptors and their downstream targets. Read More

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http://dx.doi.org/10.17925/EE.2020.16.1.32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308097PMC

Corticosteroid Pulse Therapy for Graves' Ophthalmopathy Reduces the Relapse Rate of Graves' Hyperthyroidism.

Front Endocrinol (Lausanne) 2020 11;11:367. Epub 2020 Jun 11.

Endocrinology, Department of Clinical and Experimental Medicine, Garibaldi-Nesima Medical Center, University of Catania, Catania, Italy.

A course of anti-thyroid drugs (ATD) is the most common first line treatment for Graves' hyperthyroidism. However, hyperthyroidism relapse is frequent (30-70%). Due to the autoimmune nature of Graves' disease, the immunosuppressive treatment used for active Graves' orbitopathy (GO) may reduce the relapses after ATD discontinuation. Read More

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http://dx.doi.org/10.3389/fendo.2020.00367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301650PMC

Islet, thyroid and transglutaminase antibodies in adult Bulgarian patients with type 1 diabetes.

Endocrine 2020 Jun 27. Epub 2020 Jun 27.

Department of Endocrinology, Division of Diabetology, Medical University Sofia, Sofia, Bulgaria.

Aim: The aim of the study was to assess the prevalence and relationship of islet antibodies and autoantibodies of the most common associated autoimmune diseases-autoimmune thyroid disease (AITD) and celiac disease, in adult Bulgarian patients with type 1 diabetes of short duration.

Material And Methods: 160 type 1 diabetes patients, of mean age 36.3 ± 10. Read More

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http://dx.doi.org/10.1007/s12020-020-02395-1DOI Listing

The importance of nutritional factors and dietary management of Hashimoto's thyroiditis.

Ann Agric Environ Med 2020 Jun 2;27(2):184-193. Epub 2019 Oct 2.

Nencki Institute of Experimental Biology PAN, Poland.

Hashimoto (HT) is an autoimmune disease in which destruction of the thyroid occurs as a result of lymphocyte infiltration. It is caused by an increased level of titers of antibody against thyroid peroxidase (TPO) and thyroglobulin (TG). Because of that,in HT patients, changes are observed in the level and metabolism of thyroid hormones, which leads to unspecified physical and psychological symptoms. Read More

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http://dx.doi.org/10.26444/aaem/112331DOI Listing

Putative protective role of autoantibodies against the insulin-like growth factor-1 receptor in Graves' Disease: results of a pilot study.

J Endocrinol Invest 2020 Jun 25. Epub 2020 Jun 25.

Department of Clinical and Experimental Medicine, Endocrinology Units, University of Pisa and University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy.

Background: The insulin-like growth factor-1 receptor (IGF-1R) is a key element in the pathogenesis of Graves' Orbitopathy (GO), but the role of IGF-1R autoantibodies (IGF-1RAbs) has not been established.

Methods: We designed a cross-sectional investigation to measure IGF-1RAbs in patients with Graves' disease (GD), with or without GO, who underwent radioiodine therapy followed by glucocorticoids (GC). Twenty-nine patients were included, 15 of which with GO. Read More

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http://dx.doi.org/10.1007/s40618-020-01341-2DOI Listing

Long-term efficacy and safety of alemtuzumab in patients with RRMS: 12-year follow-up of CAMMS223.

J Neurol 2020 Jun 24. Epub 2020 Jun 24.

University of Cambridge, Cambridge, UK.

Background: In the phase 2 CAMMS223 trial (NCT00050778), alemtuzumab significantly improved clinical and MRI outcomes versus subcutaneous interferon beta-1a over 3 years in treatment-naive patients with relapsing-remitting MS. Here, we assess efficacy and safety of alemtuzumab over 12 years in CAMMS223 patients who enrolled in the CAMMS03409 extension (NCT00930553), with available follow-up through the subsequent TOPAZ extension (NCT02255656).

Methods: In CAMMS223, patients received 2 alemtuzumab courses (12 mg/day; baseline: 5 days; 12 months later: 3 days); 22% received a third course. Read More

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http://dx.doi.org/10.1007/s00415-020-09983-1DOI Listing

Long-Term Follow-Up and Outcomes of Autoimmune Thyroiditis in Childhood.

Front Endocrinol (Lausanne) 2020 5;11:309. Epub 2020 Jun 5.

Pediatric Endocrine Institute, Ha'Emek Medical Center, Afula, Israel.

Autoimmune thyroiditis (AIT) is the most common cause of acquired hypothyroidism in children. The natural outcome of AIT in childhood has been reported previously however follow-up duration is generally short and results variable. To characterize clinical and biochemical findings at presentation of AIT, evaluate long-term outcomes and assess which factors at presentation predict evolution over time. Read More

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http://dx.doi.org/10.3389/fendo.2020.00309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291832PMC

Relations of prediabetes and type 2 diabetes to the thyroid cancer.

Endocr Connect 2020 Jun 1. Epub 2020 Jun 1.

M Hill, Institute of Endocrinology, Institute of Endocrinology, Praha, Czech Republic.

Objective: Patients with type 2 diabetes (T2DM) generally experience a higher incidence of cancer. However, the association between T2DM and thyroid cancer is inconclusive.

Methods: Case-control prospective study, 722 patients were screened for T2DM and prediabetes (PDM) and underwent thyroid ultrasound and biochemical tests. Read More

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http://dx.doi.org/10.1530/EC-20-0180DOI Listing

MANAGEMENT OF ENDOCRINE DISEASE Subclinical hypothyroidism in children.

Eur J Endocrinol 2020 Aug;183(2):R13-R28

Department of Mother and Child, Paediatric Endocrinology Unit, University Hospital 'Federico II', Naples, Italy.

Subclinical hypothyroidism (SH) is biochemically defined as serum TSH levels above the upper limit of the reference range in the presence of normal free T4 (FT4) concentrations. While there is a general agreement to treat subjects with serum TSH levels above 10 mU/L, the management of mild form (TSH concentrations between 4.5 and 10 mU/L) is still a matter of debate. Read More

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http://dx.doi.org/10.1530/EJE-20-0051DOI Listing

Alemtuzumab-induced halo nevus-like hypopigmentation -: New insights into secondary skin autoimmunity in response to an immune cell-depleting antibody.

J Eur Acad Dermatol Venereol 2020 Jun 24. Epub 2020 Jun 24.

Clinic of Neurology with Institute for Translational Neurology, University of Münster, Münster, Germany.

We describe a 33-year-old male patient who developed hypopigmentation around his melanocytic nevi with disappearance of the nevi in August 2018. In June 2016 he had been diagnosed with highly active RRMS and treated with alemtuzumab in September 2016 for the first time. In September 2017 another cycle of alemtuzumab was administered. Read More

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http://dx.doi.org/10.1111/jdv.16781DOI Listing

Use of strain ultrasound elastography versus fine-needle aspiration cytology for the differential diagnosis of thyroid nodules: a retrospective analysis.

Clinics (Sao Paulo) 2020 22;75:e1594. Epub 2020 Jun 22.

Department of Doppler Ultrasonil, Xingtai People's Hospital, Xingtai, Hebei, China, 054001.

Objective: Fine-needle aspiration cytology is the risk stratification tool for thyroid nodules, and ultrasound elastography is not routinely used for the differential diagnosis of thyroid cancer. The current study aimed to compare the diagnostic parameters of ultrasound elastography and fine-needle aspiration cytology, using surgical pathology as the reference standard.

Methods: In total, 205 patients with abnormal thyroid function test results underwent ultrasound-guided fine-needle aspiration cytology on the basis of the American College of Radiology Thyroid Imaging-Reporting and Data System classification and strain ultrasound elastography according to the ASTERIA criteria. Read More

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http://dx.doi.org/10.6061/clinics/2020/e1594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297517PMC

Thyroid-stimulating hormone receptor (TSHR) fusion proteins in Graves' disease.

J Endocrinol 2020 Aug;246(2):135-147

Procorde - advancecor, Martinsried, Germany.

Graves' disease is an autoimmune disorder, which is characterized by stimulatory antibodies targeting the human thyrotropin receptor (TSHR), resulting in hyperthyroidism and multiple organ damage. We systematically investigated monomeric and dimeric fusion proteins of the A subunit of TSHR for efficacy to bind to the monoclonal patient antibody M22, to interact with Graves' patient serum samples, and to impact on anti-TSHR antibody titers, hyperthyroidism, tachycardia and other in vivo read-outs in a long-term mouse model of Graves' disease induced by immunization with a recombinant adenovirus encoding TSHR A. Binding assays and functional measurements of TSHR-dependent cAMP formation showed binding of monomeric TSHR-His and dimeric TSHR-Fc to the anti-TSHR antibody M22 at low-effective concentrations (EC50 of 5. Read More

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http://dx.doi.org/10.1530/JOE-20-0061DOI Listing

Apoptosis in Autoimmunological Diseases, with Particular Consideration of Molecular Aspects of Psoriasis.

Med Sci Monit 2020 Jun 22;26:e922035. Epub 2020 Jun 22.

Department of Molecular Biology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Sosnowiec, Poland.

Apoptosis is a natural physiological process involving programmed cell death. Thanks to this process, it is possible to maintain the homeostasis of the body and the immune system. Dysfunctions of this mechanism lead to development of autoimmune diseases such as psoriasis; these diseases are chronic and treatment is extremely difficult. Read More

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http://dx.doi.org/10.12659/MSM.922035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331484PMC

Clinical Management and Therapeutic Strategies for the Thyroid-Associated Ophthalmopathy: Current and Future Perspectives.

Curr Eye Res 2020 Jun 21:1-17. Epub 2020 Jun 21.

Department of Centre of Advanced Research (CFAR), King George's Medical University (KGMU) , Lucknow, India.

Purpose: TAO is an organ specific autoimmune disease associated with thyroid, and inflammation of the orbit and periorbital tissues, which is different from systemic autoimmune diseases such as SLE. However, Grave's disease is a kind of systemic autoimmune syndrome which might involve the thyroid, the eye ball and the anterior tibial tissue. Considering the inexplicable understanding of TAO pathogenesis, the disease worsens for the patients. Read More

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http://dx.doi.org/10.1080/02713683.2020.1776331DOI Listing

Associations of Yersinia enterocolitica infection with autoimmune thyroid diseases: a systematic review and meta-analysis.

Endocr Metab Immune Disord Drug Targets 2020 Jun 21. Epub 2020 Jun 21.

Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran. Iran.

Introduction: Yersinia enterocolitica infection is reportedly associated with the development of autoimmune thyroid diseases (AITD). However, evidence that such infection can lead to AITD is controversial. Thus, this study was aimed to investigate the associations of Y. Read More

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http://dx.doi.org/10.2174/1871530320666200621180515DOI Listing

Clinical diagnostic performance of a fully automated TSI immunoassay vs. that of an automated anti‑TSHR immunoassay for Graves' disease: a Chinese multicenter study.

Endocrine 2020 Jun 19. Epub 2020 Jun 19.

Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science, Beijing, 100730, China.

Background: Both thyroid-stimulating immunoglobulins immunoassay (TSI IA) and thyrotrophin receptor antibody immunoassay (TRAb IA) are commonly used for the diagnosis of Graves' disease (GD). The aim of the present study was to compare the clinical diagnostic performance of these two methods.

Methods: Sera were obtained from 1103 subjects presenting a variety of clinical conditions from three centers: 100 subjects with untreated GD, 200 with treated GD, 62 with autoimmune thyroid disease(AIT), 216 with other thyroid diseases (OTHER-T), 214 with non-thyroid autoimmune diseases (NTAD), 191 with other diseases (OD), and 120 healthy subjects (HS). Read More

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http://dx.doi.org/10.1007/s12020-020-02386-2DOI Listing

Insulin autoimmune syndrome.

Endocrinol Diabetes Metab Case Rep 2020 Jun 4;2020. Epub 2020 Jun 4.

Laboratory of Inherited Endocrine Disorders, Endocrinology Research Centre (ERC), Moscow, Russia.

Summary: Insulin autoimmune syndrome (Hirata's disease) is a disorder caused by development of autoantibodies to insulin and manifested by hypoglycaemic syndrome. The overwhelming majority of physicians do not include it in the differential diagnosis of hypoglycaemic states because of a misconception of an extremely low prevalence of this condition. This results in unnecessary drug therapy and unjustified surgical interventions in patients that otherwise would be successfully treated conservatively. Read More

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http://dx.doi.org/10.1530/EDM-19-0159DOI Listing

Pediatric differentiated thyroid carcinoma: An update from the APSA Cancer Committee.

J Pediatr Surg 2020 May 11. Epub 2020 May 11.

Department of Surgery, Boys Town National Research Hospital, Omaha, NE.

Background: Differentiated thyroid carcinomas (DTCs) are rare in young children but represent almost 10% of all malignancies diagnosed in older adolescents.

Methods: This article reviews the recent literature describing surgical therapeutic approaches to pediatric DTC, associated complications, and long-term recurrence and survival outcomes.

Results: Similar to adult thyroid cancers, pediatric DTCs are more common in females and are associated with thyroid nodules, family history of thyroid cancer, radiation exposure, iodine deficiency, autoimmune thyroid disease, and genetic syndromes. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2020.05.003DOI Listing

Thyroid-Gut-Axis: How Does the Microbiota Influence Thyroid Function?

Nutrients 2020 Jun 12;12(6). Epub 2020 Jun 12.

Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria.

A healthy gut microbiota not only has beneficial effects on the activity of the immune system, but also on thyroid function. Thyroid and intestinal diseases prevalently coexist-Hashimoto's thyroiditis (HT) and Graves' disease (GD) are the most common autoimmune thyroid diseases (AITD) and often co-occur with Celiac Disease (CD) and Non-celiac wheat sensitivity (NCWS). This can be explained by the damaged intestinal barrier and the following increase of intestinal permeability, allowing antigens to pass more easily and activate the immune system or cross-react with extraintestinal tissues, respectively. Read More

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http://dx.doi.org/10.3390/nu12061769DOI Listing

A Steady Cause of Unsteadiness: A Case of Thyroid-Associated Cerebellar Ataxia.

Cureus 2020 May 12;12(5):e8080. Epub 2020 May 12.

Endocrinology, Johns Hopkins Hospital, Baltimore, USA.

Encephalopathy with autoimmune thyroid disease (EAATD) is mostly associated with Hashimoto's thyroiditis and has been uncommonly reported with Grave's disease. This case is aimed to report the association of EAATD with thyroid peroxidase (TPO) and thyroid-stimulating immunoglobulin (TSI) antibodies in Grave's disease. We report a 55-year old male who presented with thyrotoxicosis and cerebellar ataxia and was diagnosed with Grave's disease based on clinical and biochemical findings. Read More

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http://dx.doi.org/10.7759/cureus.8080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292692PMC

A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases.

J Vis Exp 2020 May 29(159). Epub 2020 May 29.

Barbara Davis Center for Diabetes, University of Colorado School of Medicine;

Islet autoantibodies (IAbs) are widely used in type 1 diabetes (T1D) diagnosis and prediction. Four major IAbs to insulin (IAA), glutamate decarboxylase-65 (GADA), insulinoma antigen-2 (IA-2A), and zinc transporter-8 (ZnT8A) are equally important in disease prediction. Presently, up to 40% of patients diagnosed with T1D go on to develop other autoimmune disorders. Read More

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http://dx.doi.org/10.3791/61160DOI Listing

Volume, outcomes, and quality standards in thyroid surgery: an evidence-based analysis-European Society of Endocrine Surgeons (ESES) positional statement.

Langenbecks Arch Surg 2020 Jun 10. Epub 2020 Jun 10.

Secció del Servei de Cirurgia General de l'Hospital del Mar, Barcelona, Spain.

Introduction: Continuous efforts in surgical speciality aim to improve outcome. Therefore, correlation of volume and outcome, developing subspecialization, and identification of reliable parameters to identify and measure quality in surgery gain increasing attention in the surgical community as well as in public health care systems, and by health care providers. The need to investigate these correlations in the area of endocrine surgery was identified by ESES, and thyroid surgery was chosen for this analysis of the prevalent literature with regard to outcome and volume. Read More

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http://dx.doi.org/10.1007/s00423-020-01907-xDOI Listing

The role of N-methyladenosine (mA) modification in the regulation of circRNAs.

Mol Cancer 2020 06 10;19(1):105. Epub 2020 Jun 10.

Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.

N-methyladenosine (mA), the most abundant modification in eukaryotic cells, regulates RNA transcription, processing, splicing, degradation, and translation. Circular RNA (circRNA) is a class of covalently closed RNA molecules characterized by universality, diversity, stability and conservatism of evolution. Accumulating evidence shows that both mA modification and circRNAs participate in the pathogenesis of multiple diseases, such as cancers, neurological diseases, autoimmune diseases, and infertility. Read More

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http://dx.doi.org/10.1186/s12943-020-01224-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285594PMC

Co-occurrence between C1 esterase inhibitor deficiency and autoimmune disease: a systematic literature review.

Allergy Asthma Clin Immunol 2020 27;16:41. Epub 2020 May 27.

CSL Behring, Marburg, Germany.

Background: Hereditary angioedema (HAE) is caused by a SERPING1 gene defect resulting in decreased (Type I) or dysfunctional (Type II) C1 esterase inhibitor (C1-INH). The prevalence of autoimmune diseases (ADs) in patients with HAE appears to be higher than the general population. A systematic literature review was conducted to examine the co-occurrence between HAE and ADs. Read More

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http://dx.doi.org/10.1186/s13223-020-00437-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254644PMC

Thyroid disease in the time of COVID-19.

Endocrine 2020 06 7;68(3):471-474. Epub 2020 Jun 7.

Centre for Endocrinology, Barts and the London School of Medicine, Queen Mary University of London, London, UK.

The novel coronavirus disease COVID-19 is produced by SARS-CoV-2. WHO has declared COVID-19 as a public health emergency, with the most susceptible populations (requiring ventilation) being the elderly, pregnant women and people with associated co-morbidities including heart failure, uncontrolled diabetes, chronic obstructive pulmonary disease, asthma and cancer. However, such general guidance does not provide information regarding COVID-19 risks in patients with suffering from pre-existing thyroid problems, and furthermore, we do not know whether patients with COVID-19 (symptomatic or without symptoms), who have not previously had thyroid issues develop endocrine thyroid dysfunction after infection. Read More

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http://dx.doi.org/10.1007/s12020-020-02364-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275975PMC

Celiac Disease Screening for High-Risk Groups: Are We Doing It Right?

Dig Dis Sci 2020 Jun 5. Epub 2020 Jun 5.

Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, School of Medicine, University of Virginia, MR-4 Bldg, 409 Lane Rd., Charlottesville, VA, 22908, USA.

Celiac disease (CD) is an immune-mediated enteropathy triggered by dietary ingestion of gluten in genetically susceptible patients. CD is often diagnosed by a "case-finding" approach of symptomatic patients. In recent times, the diagnostic paradigm has shifted to investigate patients who may be asymptomatic, but are at high risk of developing CD due to shared genetic susceptibilities. Read More

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http://dx.doi.org/10.1007/s10620-020-06352-wDOI Listing

An intronic HCP5 variant is associated with age of onset and susceptibility to Graves' disease in UK and Polish cohorts.

J Clin Endocrinol Metab 2020 Jun 5. Epub 2020 Jun 5.

Translational and Clinical Research Institute, Newcastle University, Newcastle-Upon-Tyne, UK.

Context: The genetic background of young onset Graves' disease (GD) remains largely unknown. An intronic variant in HLA complex P5 (HCP5) has previously been associated with GD susceptibility and age of onset in a cohort of Polish patients.

Objective: We aimed to investigate the association of the HCP5 variant rs3094228 with GD susceptibility and age of onset in a UK cohort and conduct a meta-analysis of UK and Polish data. Read More

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http://dx.doi.org/10.1210/clinem/dgaa347DOI Listing