Search our Database of Scientific Publications and Authors

I’m looking for a

    948 results match your criteria Autoimmune Thyroid Disease & Pregnancy

    1 OF 19

    Insulin autoimmune syndrome in a pregnant female: A rare case report.
    Medicine (Baltimore) 2017 Dec;96(51):e9213
    Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
    Rationale: Insulin autoimmune syndrome (IAS) is an uncommon disorder characterized by hyperinsulinemic hypoglycemia related to insulin-binding autoantibodies. To the best of our knowledge, we report the first case of a pregnant female with IAS.

    Patient Concerns: The 26-year-old patient with Graves disease and 10 weeks pregnant developed IAS after approximately 6 months treatment with methimazole. Read More

    Association of Hysteroscopic vs Laparoscopic Sterilization With Procedural, Gynecological, and Medical Outcomes.
    JAMA 2018 01;319(4):375-387
    Department of Epidemiology of Health Products, French National Agency for Medicines and Health Products Safety (ANSM), Saint-Denis, France.
    Importance: Safety of hysteroscopic sterilization has been recently questioned following reports of general symptoms such as allergy, tiredness, and depression in addition to associated gynecological results such as pelvic pain, perforation of fallopian tubes or uterus, and unwanted pregnancy.

    Objective: To compare the risk of reported adverse events between hysteroscopic and laparoscopic sterilization.

    Design, Setting, And Participants: French nationwide cohort study using the national hospital discharge database linked to the health insurance claims database. Read More

    Autoimmune thyroid disease during pregnancy.
    Lancet Diabetes Endocrinol 2017 Dec 12. Epub 2017 Dec 12.
    Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, Boston MA, USA. Electronic address:
    Understanding of changes in thyroid function and the consequences of thyroid disease during pregnancy has rapidly grown in the past two decades, and revised American Thyroid Association guidelines on this topic were published in 2017. This Review explores the association between thyroid autoimmunity and complications during and after pregnancy. Thyroid autoimmunity refers to the presence of antibodies to thyroperoxidase or thyroglobulin, or thyroid-stimulating hormone receptor antibodies (TRAbs), or a combination of these, and is present in up to 18% of pregnant women. Read More

    [Thyroid screening in pregnancy - guideline in practice].
    Vnitr Lek Fall 2017;63(9):555-560
    Thyroid diseases may adversely affect the conception, maintain pregnancy. They increase the risk of complications in pregnancy and may have a negative effect on the fetus. Therefore it is necessary to capture thyroid diseases in the population of pregnant women, in the early stage of pregnancy. Read More

    Benign thyroid disease in pregnancy: A state of the art review.
    J Clin Transl Endocrinol 2016 Dec 23;6:37-49. Epub 2016 Nov 23.
    Endocrinology and Diabetes, Salford Royal NHS Foundation Trust, Salford, Greater Manchester, UK.
    Thyroid dysfunction is the commonest endocrine disorder in pregnancy apart from diabetes. Thyroid hormones are essential for fetal brain development in the embryonic phase. Maternal thyroid dysfunction during pregnancy may have significant adverse maternal and fetal outcomes such as preterm delivery, preeclampsia, miscarriage and low birth weight. Read More

    There is no association between the presence of anti-thyroid antibodies and increased reproductive loss in pregnant women after ART: a systematic review and meta-analysis.
    JBRA Assist Reprod 2017 Dec 1;21(4):361-365. Epub 2017 Dec 1.
    Reproductive Medicine Unit at Clinica Monteblanco.
    Women submitted to ART treatments represent a select subgroup of individuals. Several studies have described the relationship between TAI and pregnancy outcomes as a result of ART, with contradictory results. The purpose of this systematic review was to determine the association between TAI and the risk of miscarriage in pregnancies resulting from ART. Read More

    Ketosis-prone diabetes and SLE co-presenting in an African lady with previous gestational diabetes.
    Endocrinol Diabetes Metab Case Rep 2017 6;2017. Epub 2017 Oct 6.
    Department of Diabetes and Endocrinology, Newham University Hospital, Barts Health NHS Trust, London, UK.
    We describe the case of an African woman who was diagnosed with ketosis-prone diabetes with diabetes-associated autoantibodies, after being admitted for diabetic ketoacidosis (DKA) precipitated by her first presentation of systemic lupus erythematosus (SLE). She had a seven-year history of recurrent gestational diabetes (GDM) not requiring insulin therapy, with return to normoglycaemia after each pregnancy. This might have suggested that she had now developed type 2 diabetes (T2D). Read More

    MECHANISMS IN ENDOCRINOLOGY: Maternal thyroid dysfunction during pregnancy and behavioural and psychiatric disorders of children: a systematic review.
    Eur J Endocrinol 2017 Nov;177(5):R261-R273
    Institute for Social Science ResearchUniversity of Queensland, Brisbane, Australia.
    Background: Maternal thyroid dysfunction during pregnancy may lead to persistent neurodevelopmental disorders in the offspring appearing in later life. This study aimed to review the available evidence concerning the relationship between maternal thyroid status during pregnancy and offspring behavioural and psychiatric disorders.

    Methods: Systematic electronic database searches were conducted using PubMed, Embase, PsycNET, Scopus, Google Scholar and Cochrane library. Read More

    Severe selenium deficits in pregnant women irrespective of autoimmune thyroid disease in an area with marginal selenium intake.
    J Trace Elem Med Biol 2017 Dec 4;44:186-191. Epub 2017 Aug 4.
    Institute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
    Objectives: Selenium (Se) deficiency is related to an increased risk of preterm labor, miscarriage, preeclampsia, gestational diabetes, and other obstetric complications. As the Se status declines during pregnancy, we hypothesized that the decline may be exacerbated in women with autoimmune thyroid disease (AITD).

    Material And Methods: Pregnant women (n=74; 30 [23-38] years) were consecutively recruited from the district of Warsaw, Poland, and divided into healthy subjects (HS, n=45), and women with a diagnosis of AITD (AITD, n=29). Read More

    Parity and Risk of Thyroid Autoimmunity Based on the NHANES (2001-2002, 2007-2008, 2009-2010, and 2011-2012).
    J Clin Endocrinol Metab 2017 Sep;102(9):3437-3442
    Division of Endocrinology and Metabolism, Harbor-University of California Los Angeles Medical Center, Torrance, California 90502.
    Context: Autoimmune thyroid disease is more common in women than in men. Fetal microchimerism has been implicated as a potential explanation for this disparity.

    Objective: The objective of this study was to evaluate the relationship between parity and thyroid autoimmunity in the US population. Read More

    Thyroid Autoimmunity and Antiphospholipid Syndrome: Not Such a Trivial Association.
    Front Endocrinol (Lausanne) 2017 21;8:175. Epub 2017 Jul 21.
    Department of Internal Medicine, Archet-1 Hospital, University Hospital of Nice, Nice, France.
    Antiphospholipid syndrome (APS) is an autoimmune disease that manifests as recurrent venous or arterial thrombosis and/or pregnancy-related complications in the presence of persistent antiphospholipid (aPL) antibodies measured at least 3 months apart. APS occurs either as a primary condition or as a part of an underlying disorder, usually systemic lupus erythematosus (SLE). Otherwise, APS may be frequently associated with autoimmune disorders. Read More

    Vitamin D deficiency in an Italian cohort of infertile women.
    Am J Reprod Immunol 2017 Oct 3;78(4). Epub 2017 Aug 3.
    Polymedical Center for Prevention of Recurrent Spontaneous Abortion, Rome, Italy.
    Problem: The purpose of this study was to explore whether vitamin D might be a marker of female primary infertility in association with the presence of autoimmune diseases (ADs).

    Methods: The study was a cross-sectional descriptive study in consecutive outpatients of the Polymedical Center for Prevention of Recurrent Spontaneous Abortion (RSA), in Rome, Italy. Women were eligible if they received a diagnosis of primary infertility or RSA. Read More

    Autoimmune hypothyroidism is three times more frequent in female prolactinoma patients compared to healthy women: data from a cross-sectional case-control study.
    Endocrine 2017 Sep 19;57(3):486-493. Epub 2017 Jul 19.
    University Hospital of Endocrinology, Sofia, Bulgaria.
    Background: The potent immunomodulatory action of prolactin has been demonstrated in many experimental in vitro studies. In accordance with these data, our retrospective analyses revealed higher prevalence of autoimmune thyroid diseases in prolactinoma patients compared to general population.

    Purpose: A cross-sectional case-control study was carried out in a single tertiary referral centre. Read More

    Risk Factors for Postpartum Thyroid Dysfunction in Euthyroid Women Prior to Pregnancy.
    Folia Med (Plovdiv) 2017 06;59(2):190-196
    Section of Endocrinology, Department of Internal Diseases, Faculty of Medicine, Medical University of Plovdiv, Plovdiv, Bulgaria
    Background: Thyroid dysfunction is common during the postpartum and the predisposing factors for its development are considered specific for the population studied. The aim of this study was to evaluate the risk factors for the occurrence of postpartum thyroid dysfunction (PPTD) in euthyroid women prior to pregnancy.

    Materials And Methods: Forty-five women with PPTD and 55 age-matched euthyroid postpartum women from Plovdiv, Bulgaria were included in the study. Read More

    The microbiota and autoimmunity: Their role in thyroid autoimmune diseases.
    Clin Immunol 2017 10 6;183:63-74. Epub 2017 Jul 6.
    Division of Infection & Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom.
    Since the 1970s, the role of infectious diseases in the pathogenesis of Graves' disease (GD) has been an object of intensive research. The last decade has witnessed many studies on Yersinia enterocolitica, Helicobacter pylori and other bacterial organisms and their potential impact on GD. Retrospective, prospective and molecular binding studies have been performed with contrary outcomes. Read More

    Medical conditions associated with recurrent miscarriage-Is BMI the tip of the iceberg?
    Eur J Obstet Gynecol Reprod Biol 2017 Jul 3;214:91-96. Epub 2017 May 3.
    Department of Obstetrics and Gynaecology, Groote Schuur Hospital, Cape Town, 7937, South Africa.
    Background: In contrast to sporadic miscarriage, recurrent miscarriage (RM) is a rare entity which affects 1% of couples attempting conception. It is distressing for couples and healthcare professionals as the aetiology is unclear with limited treatment options. Apart from anti-phospholipid syndrome (APS), the strength of associations between RM and commonly investigated endocrine, autoimmune, thrombophilic and uterine structural abnormalities remains uncertain and variable. Read More

    A Retrospective Study on the Association between Thyroid Autoantibodies with β2-glycoprotein and Cardiolipin Antibodies in Recurrent Miscarriage.
    Iran J Allergy Asthma Immunol 2017 Feb;16(1):72-76
    Clinical Division of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Vienna, Austria.
    Etiologic factors for recurrent miscarriage (RM) include autoimmune diseases, the most frequently antiphospholipid syndrome and thyroiditis. Some women who suffer from RM might also have an altered immune system. We aimed to evaluate possible associations between anti-thyroid and anti-phospholipid antibodies in women with RM. Read More

    Patients with subclinical hypothyroidism before 20 weeks of pregnancy have a higher risk of miscarriage: A systematic review and meta-analysis.
    PLoS One 2017 17;12(4):e0175708. Epub 2017 Apr 17.
    The Endocrine Institute and The Liaoning Provincial Key Laboratory of Endocrine Diseases, Department of Endocrinology and Metabolism, The First Hospital of China Medical University, Shenyang, China.
    Objective: To evaluate the relationship between subclinical hypothyroidism (SCH) and the risk of miscarriage before 20 weeks of pregnancy.

    Methods: Literature databases were searched, including the PubMed, Web of Science, Embase and Cochrane databases, from January 1, 1980, to December 31, 2015. The following search terms were used: subclinical hypothyroidism, hypothyroidism, thyroid dysfunction, thyroid hypofunction, subclinical thyroid disease, thyroid dysfunction, pregnancy loss, abortion and miscarriage. Read More

    Clinical clues for autoimmunity and neuroinflammation in patients with autistic regression.
    Dev Med Child Neurol 2017 09 6;59(9):947-951. Epub 2017 Apr 6.
    Division of Pediatric Neurology, University of Alberta, Edmonton, AB, Canada.
    Aim: Autistic regression is a unique variant within the autism spectrum disorders (ASDs), with recent reports raising the possibility of immune aetiology. This study explores clinical clues for an association between autistic regression and autoimmunity.

    Method: Single-centre charts of children diagnosed with ASD in 2014 were reviewed. Read More

    Increase in thyroglobulin antibody and thyroid peroxidase antibody levels, but not preterm birth-rate, in pregnant Danish women upon iodine fortification.
    Eur J Endocrinol 2017 May;176(5):603-612
    Departments of Medical EndocrinologySection 2132.
    Objective: The presence of thyroid antibodies in pregnancy has been associated with preterm birth. In the non-pregnant population, the implementation of the Danish iodine fortification program has increased the prevalence of thyroid antibodies. This study investigated the prevalence of thyroid peroxidase antibodies (TPOAbs) and thyroglobulin antibodies (TgAbs) in pregnant Danish women before, during and after implementation of the iodine fortification program and association with preterm birth. Read More

    Imprinting of maternal thyroid hormones in the offspring.
    Int Rev Immunol 2017 Jul 8;36(4):240-255. Epub 2017 Mar 8.
    a Departamento de Ciencias Biológicas , Millennium Institute on Immunology and Immunotherapy, Facultad de Ciencias Biológicas y Facultad de Medicina, Universidad Andres Bello , Santiago , Chile.
    Thyroid hormones (THs) during pregnancy contribute significantly to cellular differentiation and development in several tissues of the offspring, principally the central nervous system (CNS). TH deficiencies, such as hypothyroidism or hypothyroxinemia, are highly frequent during pregnancy worldwide and known to be detrimental for the development of the fetus. The function of CNS in the offspring gestated under TH deficiency will be irreversible impaired, causing low intellectual quotient, attention deficit, and mental retardation. Read More

    Urinary iodine in early pregnancy is associated with subclinical hypothyroidism in Tianjin, China: an observational study.
    BMC Endocr Disord 2017 Feb 17;17(1):10. Epub 2017 Feb 17.
    Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, No154 Anshan Road, Heping District, Tianjin, 300052, China.
    Background: Subclinical hypothyroidism (SH) is associated with adverse obstetric outcomes and neurodevelopment disorders. Both iodine deficiency and excess are associated with SH; however, few data regarding iodine nutrition status of pregnant women with SH are available. This study aimed to clarify whether iodine deficiency or excess is associated with SH, especially, when test results for anti-thyroid autoantibodies are negative. Read More

    Thyroid in pregnancy: From physiology to screening.
    Crit Rev Clin Lab Sci 2017 Mar 19;54(2):102-116. Epub 2017 Jan 19.
    c Division of Internal Medicine , University Hospital Basel , Basel , Switzerland.
    Thyroid hormones are crucial for the growth and maturation of many target tissues, especially the brain and skeleton. During critical periods in the first trimester of pregnancy, maternal thyroxine is essential for fetal development as it supplies thyroid hormone-dependent tissues. The ontogeny of mature thyroid function involves organogenesis, and maturation of the hypothalamus, pituitary and the thyroid gland; and it is almost complete by the 12th-14th gestational week. Read More

    Management of Fetal and Neonatal Graves' Disease.
    Horm Res Paediatr 2017 16;87(1):1-6. Epub 2016 Dec 16.
    Service d'Endocrinologie Diabétologie Pédiatrique, Centre de Référence des Maladies Endocriniennes Rares de la Croissance, Hôpital Robert Debré, and Université Paris Diderot, Sorbonne Paris Cité, and Institut National de la Santé et de la Recherche Médicale (INSERM), Unité 1141, DHU Protect, Paris, France.
    Fetal and neonatal autoimmune hyperthyroidism is a rare, serious but transient disorder. Early diagnosis and treatment are key objectives for an optimal prognosis and the well-being of the child. This review focuses on the management of these patients during the fetal and neonatal periods. Read More

    Ethnic Differences in Preterm Birth Risks for Pregnant Women with Thyroid Dysfunction or Autoimmunity: A Meta-analysis.
    Biomed Environ Sci 2016 Oct;29(10):724-733
    Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing 100730, China.
    Objective: Abnormal maternal thyroid function is associated with preterm birth. However, this association stays dubious in relevant individual studies for ethnic difference reasons and lack of direct supporting data. This study aimed to evaluate the relationship between preterm birth and thyroid dysfunction or autoimmunity based on ethnic differences. Read More

    Effects of levothyroxine treatment on pregnancy outcomes in pregnant women with autoimmune thyroid disease.
    Eur J Endocrinol 2017 02 22;176(2):253-265. Epub 2016 Nov 22.
    Endocrine Research CenterResearch Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences and Health Services, Tehran, Iran.
    Background: Despite some studies indicating that thyroid antibody positivity during pregnancy has been associated with adverse pregnancy outcomes, evidence regarding the effects of levothyroxine (LT4) treatment of euthyroid/subclinical hypothyroid pregnant women with autoimmune thyroid disease on pregnancy outcome is limited. We aimed to assess whether pregnant women with autoimmune thyroid disease, but without overt thyroid dysfunction are affected by higher rates of adverse pregnancy outcomes. In addition, we aimed to explore whether LT4 treatment improves the pregnancy outcome of affected women. Read More

    A 2016 Italian Survey about the Clinical Use of Selenium in Thyroid Disease.
    Eur Thyroid J 2016 Sep 6;5(3):164-170. Epub 2016 Aug 6.
    Department of Endocrinology, Regina Apostolorum Hospital, Albano Laziale, Italy.
    Background: Selenium (Se) is a trace element that plays key roles in thyroid physiology. Se deficiency is associated with increased risk of thyroid disease. Some evidence suggests that Se supplementation may be beneficial in autoimmune thyroid disease (either hypo- or hyperthyroidism). Read More

    Fetal/Neonatal Thyrotoxicosis in a Newborn From a Hypothyroid Woman With Hashimoto Thyroiditis.
    J Clin Endocrinol Metab 2017 Jan;102(1):6-9
    Clinical Division of Endocrinology and Metabolism, Department of Medicine III.
    Context: Fetal/neonatal thyrotoxicosis is a rare but potentially life-threatening condition. It is most commonly observed in poorly controlled Graves disease during pregnancy.

    Case Description: Here we describe a fetus/newborn patient with thyrotoxicosis who was born of a woman with Hashimoto thyroiditis and levothyroxine-treated hypothyroidism. Read More

    Onset of Graves' disease during pregnancy in a woman with established hypothyroidism.
    Gynecol Endocrinol 2017 Jan 4;33(1):16-18. Epub 2016 Nov 4.
    a Servicio de Endocrinología y Nutrición, Complejo Hospitalario Universitario Insular Materno Infantil de Gran Canaria, Instituto Universitario de Investigaciones Biomédicas y Sanitarias, Universidad de Las Palmas de Gran Canaria , Las Palmas de Gran Canaria , Spain.
    Background: Pregnancy strongly influences the thyroid gland and its function. Thyroid guidelines recommend a 30 to 50% increase of the preconceptional levothyroxine dose in women with hypothyroidism, when pregnancy is diagnosed.

    Case: A 33 year-old, 8-week pregnant woman with hypothyroidism, presents with a 2-week history of palpitations, sweating, nervousness and fatigue. Read More

    Frequency of Thyroid Peroxidase Antibody and its Association with Miscarriages Among Pregnant Women.
    J Coll Physicians Surg Pak 2016 Oct;26(10):831-834
    Department of Obstetrics and Gynaecology, The Aga Khan University Hospital, Karachi.
    Objective: To measure the frequency of thyroid peroxidase antibody (TPO Ab) among clinically euthyroid pregnant women during first trimester and determine its association with pregnancy outcome as miscarriage or live birth by estimating the relative risk.

    Study Design: Cohort study.

    Place And Duration Of Study: Section of Chemical Pathology, Department of Pathology and Laboratory Medicine and the Gynaecology and Obstetric outpatient clinics of the Aga Khan University Hospital, Karachi, from July to December 2012. Read More

    Unexpected Elevated Free Thyroid Hormones in Pregnancy.
    Thyroid 2016 Nov 14;26(11):1640-1644. Epub 2016 Sep 14.
    2 Endocrinology Section, Department of Clinical and Experimental Medicine, University of Messina , Messina, Italy .
    Background: The use of thyrotropin and free thyroid hormone assays to evaluate thyroid function is widespread, but in some situations the results are inconsistent with the patient's thyroid status.

    Summary: A 35-year-old woman with a known diagnosis of chronic autoimmune thyroiditis was referred to the authors' clinic at week 26 of her second pregnancy. The patient was clinically euthyroid. Read More

    Overview of Hypothyroidism in Pregnancy.
    Semin Reprod Med 2016 11 14;34(6):323-330. Epub 2016 Oct 14.
    Division of Endocrinology, Diabetes and Metabolism, Corporal Michael J. Crescenz VA Medical Center and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
    Overt hypothyroidism in pregnancy, defined as an elevated serum thyroid-stimulating hormone (TSH) and reduced serum free thyroxine or a TSH >10 mIU/L, is known to have adverse effects on pregnancy. Subclinical hypothyroidism is typically defined as an elevated TSH and normal FT4 levels. There remains much controversy on the benefit of starting levothyroxine for mothers diagnosed with subclinical hypothyroidism. Read More

    Managing hyperthyroidism in pregnancy: current perspectives.
    Int J Womens Health 2016 19;8:497-504. Epub 2016 Sep 19.
    Department of Endocrinology, Aalborg University Hospital; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
    Hyperthyroidism in women who are of childbearing age is predominantly of autoimmune origin and caused by Graves' disease. The physiological changes in the maternal immune system during a pregnancy may influence the development of this and other autoimmune diseases. Furthermore, pregnancy-associated physiological changes influence the synthesis and metabolism of thyroid hormones and challenge the interpretation of thyroid function tests in pregnancy. Read More

    [Endocrine problems during pregnancy].
    Dtsch Med Wochenschr 2016 Sep 6;141(18):1304-12. Epub 2016 Sep 6.
    Endocrine disorders may have an important influence on fertility, the course of a pregnancy and fetal development. For example, fertility is decreased and the risk of miscarriage is increased in women with autoimmune disorders, such as Addison's disease or autoimmune thyroiditis. Treatment of endocrine diseases in many cases has to be adapted during the course of a pregnancy. Read More

    Hypothyroidism incidence in and around pregnancy: a Danish nationwide study.
    Eur J Endocrinol 2016 Nov 10;175(5):387-93. Epub 2016 Aug 10.
    Departments of Endocrinology Department of Clinical MedicineAalborg University, Aalborg, Denmark.
    Objective: Immunological changes in and after a pregnancy may influence the onset of autoimmune diseases. An increased incidence of hyperthyroidism has been observed both in early pregnancy and postpartum, but it remains to be studied if the incidence of hypothyroidism varies in a similar way.

    Design: Population-based cohort study using Danish nationwide registers. Read More

    Med Pregl 2016 Jan-Feb;69(1-2):11-5
    Introduction: Depleted uranium radiation and pollution with polychlorinated biphenyls resulting from bombings the territories of Serbia as well as the additional long-term stress may have affected the function of thyroid gland. The objective of this study was to determine the trend of drug utilization in the treatment of thyroid dysfunction during pregnancy in Novi Sad.

    Material And Methods: Women who had given birth at the Department of Gynecology in 1989, 1999, 2007 and 2011 were interviewed during a one-month period about thyroid diseases in the pregnancy as well as the drugs they had taken. Read More

    Genetic Syndromes, Maternal Diseases and Antenatal Factors Associated with Autism Spectrum Disorders (ASD).
    Front Neurosci 2016 6;10:316. Epub 2016 Jul 6.
    Laboratory of Teratology, Department of Medical Neurobiology, Hadassah Medical School, Hebrew UniversityJerusalem, Israel; Department of Neonatology, Hadassah-Hebrew University Medical CenterJerusalem, Israel.
    Autism spectrum disorder (ASD) affecting about 1% of all children is associated, in addition to complex genetic factors, with a variety of prenatal, perinatal, and postnatal etiologies. In addition, ASD is often an important clinical presentation of some well-known genetic syndromes in human. We discuss these syndromes as well as the role of the more important prenatal factors affecting the fetus throughout pregnancy which may also be associated with ASD. Read More

    Prevalence of thyroid autoimmunity and dysfunction in women with iron deficiency during early pregnancy: is it altered?
    Eur J Endocrinol 2016 Sep 22;175(3):191-9. Epub 2016 Jul 22.
    Endocrine Unit
    Objective: Thyroid disorders and iron deficiency (ID) are associated with obstetrical and fetal complications. Iron is essential for the normal functioning of thyroid peroxidase (TPO-abs) and ID is frequent during pregnancy. The aim of this study was to compare the prevalence of thyroid autoimmunity (TAI) and dysfunction during the first trimester of pregnancy in women with and without ID. Read More

    A primer on pituitary injury for the obstetrician gynecologist: Simmond's disease, Sheehan's Syndrome, traumatic injury, Dahan's Syndrome, pituitary apoplexy and lymphocytic hypophysitis.
    Minerva Ginecol 2017 Apr 13;69(2):190-194. Epub 2016 Jul 13.
    McGill Reproductive Center, McGill University, Royal Victoria Hospital, Montreal, Canada.
    The pituitary gland plays a critical role in reproduction. In response to the hypothalamus the anterior pituitary secretes prolactin, thyroid-stimulating hormone, adreno-corticotropic hormone, follicle-stimulating hormone, luteinizing hormone and growth hormone. Dysregulation in these hormones often lead to reproductive failure. Read More

    [The role of color doppler ultrasonography, thyroid function and auto antibody for the screening of Graves' disease in pregnancy].
    Zhonghua Nei Ke Za Zhi 2016 Jun;55(6):470-3
    Department of Endocrinology Shenzhen People's Hospital, Shenzhen 518020, China.
    Objective: To determine whether color doppler ultrasonography (CDU), thyroid function or thyroid autoimmune antibodies could identify Graves' disease in pregnancy(GDP) in pregnant patients with newly diagnosed thyrotoxicosis.

    Methods: It is an observational study. Sixty-eight pregnant patients with newly diagnosed thyrotoxicosis including gestational hyperthyroidism(GHT) subjects (GHT group, n=33) and GDP subjects (GDP group, n=35), and 62 age-and sex-matched healthy subjects (C1 group: pregnant, n=32, C2 group: non-pregnant, n=30) were recruited. Read More

    Anti-C1q autoantibodies are linked to autoimmune thyroid disorders in pregnant women.
    Clin Exp Immunol 2016 10 12;186(1):10-7. Epub 2016 Aug 12.
    Division of Internal Medicine, University Hospital Basel.
    Anti-C1q antibodies (anti-C1q) have been implicated in the pathogenesis of autoimmune diseases, including autoimmune thyroid disorders (AITD). The aim of this study was to evaluate the association between anti-C1q and thyroid function in pregnancy-associated AITD. In 96 pregnant women screened positive for AITD (thyroid dysfunction and/or antibodies against thyroperoxidase - TPOAb), anti-C1q were measured during the 9-11th gestational week and after delivery (median 16 months after delivery), and compared to the corresponding serum levels of thyroid hormones. Read More

    Effect of thyroid autoimmunity per se on assisted reproduction treatment outcomes: A meta-analysis.
    Taiwan J Obstet Gynecol 2016 Apr;55(2):159-65
    Institute of Reproductive & Stem Cell Engineering, Central South University, Changsha, China; Key Laboratory of Reproductive & Stem Cell Engineering, Ministry of Health, Changsha, China; Reproductive Center, Reproductive & Genetic Hospital of CITIC-Xiangya, Changsha 410078, China. Electronic address:
    Objective: Thyroid autoimmunity (TA) is the most prevalent autoimmune disease in women of reproductive age and is often accompanied by subclinical hypothyroidism (SCH). Both TA and SCH have been associated with adverse pregnancy outcomes, but their relative influence is unclear. Therefore, we carried out a meta-analysis to evaluate the sole effect of TA on pregnancy outcomes in euthyroid women undergoing assisted reproductive technology. Read More

    Blood: tests used to assess the physiological and immunological properties of blood.
    Adv Physiol Educ 2016 Jun;40(2):165-75
    Centre for Biomedical Sciences Education, School of Medicine Dentistry and Biomedical Science, Queen's University Belfast, Belfast, Northern Ireland, United Kingdom.
    The properties of blood and the relative ease of access to which it can be retrieved make it an ideal source to gauge different aspects of homeostasis within an individual, form an accurate diagnosis, and formulate an appropriate treatment regime. Tests used to determine blood parameters such as the erythrocyte sedimentation rate, hemoglobin concentration, hematocrit, bleeding and clotting times, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, mean cell volume, and determination of blood groups are routinely used clinically, and deviations outside the normal range can indicate a range of conditions such as anemia, pregnancy, dehydration, overhydration, infectious disease, cancer, thyroid disease, and autoimmune conditions, to mention a few. As these tests can be performed relatively inexpensively and do not require high levels of technical expertise, they are ideally suited for use in the teaching laboratory, enabling undergraduate students to link theory to practice. Read More

    Impact of thyroid autoimmunity on cumulative delivery rates in in vitro fertilization/intracytoplasmic sperm injection patients.
    Fertil Steril 2016 07 29;106(1):144-150. Epub 2016 Mar 29.
    Department of Gynecology and Fertility, Universitair Ziekenhuis Brussel, Brussels, Belgium; Department of Obstetrics and Gynecology, Centre Hospitalier Universitaire de Tivoli, La Louvière, Belgium.
    Objective: To predict the impact of thyroid autoimmunity (TAI) on the probability of delivery after a defined number of treatment cycles, using analysis of cumulative delivery rates in patients with and without TAI.

    Design: Retrospective cohort study performed at the Center for Reproductive Medicine and Department of Endocrinology, University Hospital of Brussels, approved by the institutional review board of the hospital.

    Setting: University hospital. Read More

    Newly diagnosed hyperthyroidism in the 25th gestational week of pregnancy presenting with systolic arterial hypertension only.
    J Obstet Gynaecol 2016 May 16;36(4):529-30. Epub 2016 Mar 16.
    a Department of Nuclear Medicine , University Medical Centre Ljubljana , Ljubljana , Slovenia and.
    We present a case of a 30-year-old woman diagnosed with arterial hypertension in the 25th week of pregnancy. Our search for secondary causes of arterial hypertension revealed hyperthyroid Hashimoto's thyroiditis (HT), which was treated with propilthiouracil. Three weeks after delivery, she was normotensive without medication. Read More

    Systemic Inflammation and Autoimmunity in Women with Chronic Endometritis.
    Am J Reprod Immunol 2016 Jun 7;75(6):672-7. Epub 2016 Mar 7.
    The Center for Human Reproduction, New York, NY, USA.
    Problem: To determine in women with recurrent pregnancy loss (RPL) and/or implantation failure (RIF) the prevalence of chronic endometritis (CE), systemic inflammation and autoimmunity, and whether they relate.

    Method Of Study: This retrospective study examined inflammatory (adiponectin, CRP, leptin, and IL6) and autoimmune (total immunoglobulins, ANA, thyroid antibodies, antiphospholipid antibodies) markers in a group of 55 women with RPL/RIF. A diagnosis of CE was reached by endometrial biopsy, demonstrating CD138-positive plasma cells on histology. Read More

    Connective tissue diseases and autoimmune thyroid disorders in the first trimester of pregnancy.
    J Reprod Immunol 2016 Apr 2;114:32-7. Epub 2016 Mar 2.
    Department of Obstetrics and Gynecology, IRCCS Foundation Policlinico San Matteo and University of Pavia, Pavia, Italy.
    Objective: To investigate the rates and coexistence of autoimmune thyroid and connective tissue diseases (CTD) during the first trimester of pregnancy and their influence on pregnancy outcome.

    Study Design: A cohort study of 150 women with CTD diagnosed during first trimester of pregnancy and 150 negative controls.

    Main Outcome Measures: Screening of CTD by a self-reported questionnaire, rheumatic and thyroid autoantibody detection, clinical rheumatological evaluation and obstetric outcomes. Read More

    Is there a role for vitamin D in human reproduction?
    Horm Mol Biol Clin Investig 2016 Jan;25(1):15-28
    Vitamin D is a steroid hormone with canonical roles in calcium metabolism and bone modeling. However, in recent years there has been a growing body of literature presenting associations between vitamin D levels and a variety of disease processes, including metabolic disorders such as diabetes and prediabetes and autoimmune conditions such as thyroid disease. This review focuses on the potential role of vitamin D in both male and female reproductive function. Read More

    [57-year-old patient with hypopituitarism and coexisting autommune hypothyroidism polyglandular syndrome--a case report].
    Przegl Lek 2015 ;72(8):445-8
    A case of 57-year-old patient with hypopituitarism multihormonal whose symptoms occurred after the last birth history of 16 years ago. Completed studies revealed other irregularities on the basis of which ultimately diagnosed with hypothyroidism polyglandular syndrome patients. Read More

    1 OF 19