10,127 results match your criteria Autoimmune Hepatitis


Depression: An Overlooked Villain in Autoimmune Hepatitis?

Hepatology 2019 Feb 17. Epub 2019 Feb 17.

Liver and Internal Medicine Unit, Medical University of Warsaw, Warsaw, Poland.

We read with great interest the recent article by Wong et al. on the impact of autoimmune hepatitis (AIH) on health-related quality of life (HRQoL). So far, this issue has been vastly neglected in patients with AIH. Read More

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http://dx.doi.org/10.1002/hep.30568DOI Listing
February 2019

Predictive criteria of response to endoscopic treatment for severe strictures in primary sclerosing cholangitis.

Clin Res Hepatol Gastroenterol 2019 Feb 13. Epub 2019 Feb 13.

Department of Radiology, Saint-Antoine Hospital, Assistance Publique-Hôpitaux de Paris AP-HP, Sorbonne university, 75012 Paris, France. Electronic address:

Background: The aim of this study was to identify predictive criteria of improvement after endoscopic treatment (ET) for severe strictures of extrahepatic bile ducts in patients with primary sclerosing cholangitis (PSC).

Methods: PSC patients who had at least one ET for severe stricture were included. Features of magnetic resonance cholangiography (MRC), performed before ET, were evaluated according to a standard model of interpretation, and a radiologic qualitative score of probability of improvement after ET was built. Read More

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http://dx.doi.org/10.1016/j.clinre.2019.01.003DOI Listing
February 2019

A plethora of manifestations following a Mycoplasma pneumoniae infection: a case report.

Acta Clin Belg 2019 Feb 15:1-6. Epub 2019 Feb 15.

e Department of Gastroenteroly , AZ Maria Middelares , Ghent , Belgium.

Mycoplasma pneumoniae infection can present with a plethora of symptoms and result in a systemic vasculitis by activating a cascade of autoimmune reactions. In this case report, a young man without relevant past medical history was admitted to the hospital with diarrhea, abdominal pain and spiking fever. A CT-scan showed terminal ileitis. Read More

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http://dx.doi.org/10.1080/17843286.2019.1578029DOI Listing
February 2019

Gut microbiota in liver disease: Too much is harmful, nothing at all is not helpful either.

Am J Physiol Gastrointest Liver Physiol 2019 Feb 15. Epub 2019 Feb 15.

Medicine, UCSD, United States.

The intestinal microbiome plays an major role in the pathogenesis of liver disease, with a hallmark event being dysbiosis, or an imbalance of pathobionts and beneficial bacteria with the associated deleterious effects on its host. Reducing the number of intestinal bacteria with antibiotic treatment is generally advantageous in experimental liver diseases. Complete absence of intestinal microbiota as in germ-free rodents can be protective in autoimmune hepatitis, and hepatic tumors induced by chemicals; or it can exacerbate disease as in acute toxic liver injury and liver fibrosis/cirrhosis. Read More

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http://dx.doi.org/10.1152/ajpgi.00370.2018DOI Listing
February 2019

Asymptomatic giant cell hepatitis: a subtype of post-infantile giant cell hepatitis?

Clin J Gastroenterol 2019 Feb 14. Epub 2019 Feb 14.

Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan.

Giant cell hepatitis in adults is considered a rapidly progressive and life-threatening disease, but there are few descriptions of a prolonged disease course. A 36-year-old Japanese man was referred to our hospital for further evaluation of abnormal liver function test results. Although asymptomatic, he had undergone follow-up for 9 years with these abnormalities. Read More

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http://dx.doi.org/10.1007/s12328-019-00950-6DOI Listing
February 2019

Systematic review with meta-analysis: mycophenolate mofetil as a second-line therapy for autoimmune hepatitis.

Aliment Pharmacol Ther 2019 Feb 13. Epub 2019 Feb 13.

Division of Hepatology, Department of Medicine, University of Miami, Miami, Florida.

Background: First-line treatment for autoimmune hepatitis (AIH) typically includes corticosteroids in combination with azathioprine. Mycophenolate mofetil (MMF) is often used as a rescue therapy in patients who are intolerant of, or nonresponsive to, standard therapy.

Aim: To systematically review studies and perform a meta-analysis on the efficacy and safety of MMF as a second-line therapy for AIH patients. Read More

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http://dx.doi.org/10.1111/apt.15157DOI Listing
February 2019

Review article: iron disturbances in chronic liver diseases other than haemochromatosis - pathogenic, prognostic, and therapeutic implications.

Authors:
Albert J Czaja

Aliment Pharmacol Ther 2019 Feb 13. Epub 2019 Feb 13.

Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine and Science, Rochester, Minnesota.

Background: Disturbances in iron regulation have been described in diverse chronic liver diseases other than hereditary haemochromatosis, and iron toxicity may worsen liver injury and outcome.

Aims: To describe manifestations and consequences of iron dysregulation in chronic liver diseases apart from hereditary haemochromatosis and to encourage investigations that clarify pathogenic mechanisms, define risk thresholds for iron toxicity, and direct management METHODS: English abstracts were identified in PubMed by multiple search terms. Full length articles were selected for review, and secondary and tertiary bibliographies were developed. Read More

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http://dx.doi.org/10.1111/apt.15173DOI Listing
February 2019

[Acute decompensation (AD) of advanced chronic liver disease (ACLD) and hepatitis E virus (HEV) infection as the trigger].

Klin Mikrobiol Infekc Lek 2018 Sep;24(3):82-87

Division Hepatology, gastroenterology and liver transplantation of Department Internal medicine II, Faculty of Medicine, Slovak Medical University, FD Roosevelt Hospital, Banska Bystrica; Slovakia, e-mail:

Introduction: HEV infection is perceived as the cause of acute hepatitis in endemic areas. In addition, it may also manifest as a possible trigger of AD or acute-on-chronic liver failure (ACLF).

Objectives: To determine the prevalence of HEV infection as a trigger of AD/ACLF in patients admitted for decompensated ACLD (dACLD). Read More

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September 2018
2 Reads

IL-37 suppresses the sustained hepatic IFN-γ/TNF-α production and T cell-dependent liver injury.

Int Immunopharmacol 2019 Feb 5;69:184-193. Epub 2019 Feb 5.

Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, People's Republic of China. Electronic address:

T cell-dependent liver injury is an important reason for the massive hepatic damage and cirrhosis. So far it is unclear whether the development of the disease could be efficiently suppressed by anti-inflammatory cytokine that modulates innate immune cells. Here we report that anti-inflammatory cytokine IL-37 could efficiently suppress the sustained hepatic expression of IFN-γ and TNF-α, two critical cytokines for inducing hepatocyte apoptosis and liver fibrosis in T cell-dependent liver injury. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15675769193019
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http://dx.doi.org/10.1016/j.intimp.2019.01.037DOI Listing
February 2019
2 Reads

Chronic hepatitis B viral infection among RA patients-a cross-sectional control study.

Clin Rheumatol 2019 Feb 8. Epub 2019 Feb 8.

Department of Medicine 'B', Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, 52621, Tel-Hashomer, Israel.

Background And Objectives: Rheumatoid arthritis (RA) is the most common inflammatory joint disorder presenting also with extra-articular manifestations. As many other autoimmune diseases, it has been suggested that infectious diseases might contribute to its emergence. Hepatitis viruses were suggested by several reports as a trigger of RA onset. Read More

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http://link.springer.com/10.1007/s10067-019-04448-x
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http://dx.doi.org/10.1007/s10067-019-04448-xDOI Listing
February 2019
4 Reads

Splenectomy Promotes Macrophage Polarization in a Mouse Model of Concanavalin A- (ConA-) Induced Liver Fibrosis.

Biomed Res Int 2019 6;2019:5756189. Epub 2019 Jan 6.

Department of Gastroenterology and Hepatology, Tianjin Medical University, General Hospital, Tianjin, China.

Background: Splenectomy can improve liver function and survival in patients with autoimmune hepatitis (AIH) and liver cirrhosis. We investigated the underlying mechanism in a mouse model of concanavalin A- (ConA-) induced liver fibrosis.

Methods: We used ConA to induce immune liver fibrosis in BALB/c mice. Read More

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http://dx.doi.org/10.1155/2019/5756189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339718PMC
January 2019
1 Read

Steroid Free Treatment of Autoimmune Hepatitis in Selected Children.

J Pediatr 2019 Feb 2. Epub 2019 Feb 2.

Children's Hospital of Philadelphia, Division of Gastroenterology, Hepatology, and Nutrition, Philadelphia, PA. Electronic address:

Current guidelines recommend steroids for induction of remission in all children diagnosed with autoimmune hepatitis regardless of the clinical presentation. In this report, we describe our experience in treating selected asymptomatic children with autoimmune hepatitis using a steroid-free regimen; this treatment strategy was safe and effective in inducing remission. Read More

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http://dx.doi.org/10.1016/j.jpeds.2018.12.070DOI Listing
February 2019
1 Read

A case of late presentation of darunavir-related cholestatic hepatitis.

Int J STD AIDS 2019 Feb 5:956462419826723. Epub 2019 Feb 5.

2 Department of Gastroenterology, Tokuda Acibadem Hospital, Sofia, Bulgaria.

We report a case of darunavir-induced cholestatic hepatitis in a human immunodeficiency virus (HIV)-infected patient in the third year of his combined antiretroviral therapy. During the patient's monthly follow-up with regard to his HIV infection, elevated transaminase levels were detected. The patient was subsequently hospitalised at the AIDS and gastroenterology departments. Read More

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http://journals.sagepub.com/doi/10.1177/0956462419826723
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http://dx.doi.org/10.1177/0956462419826723DOI Listing
February 2019
4 Reads

Autoimmune hepatitis: current and future therapeutic options.

Liver Int 2019 Feb 4. Epub 2019 Feb 4.

Toronto Centre for Liver Disease, Division of Gastroenterology and Hepatology, University Health Network, 200 Elizabeth St, Toronto, ON, M5G 2C4, Canada.

Autoimmune hepatitis (AIH) is a rare immune-mediated liver disease with few major advances in treatment options over the last several decades. Available options are effective in most patients albeit are imprecise in their mechanisms. Novel and more tolerable induction regimens and alternative options for management of patients intolerant or with suboptimal response to traditional therapies including in the post-transplant setting remain an important unmet need. Read More

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http://dx.doi.org/10.1111/liv.14062DOI Listing
February 2019

Mutation in Gene Can Cause Syndromic Multisystem Autoimmune Disease With Acute Liver Failure.

Pediatrics 2019 Jan 31. Epub 2019 Jan 31.

Departments of Pediatrics, Gastroenterology, and Hepatology and

Pediatric intractable autoimmune hepatitis is rare and may be responsible for acute liver failure. Mutations in the itchy E3 ubiquitin protein ligase () gene (located on chromosome 20q11.22) can lead to a deficiency of the encoded protein, resulting in increased T-cell activity with lack of immune tolerance and manifestation of a complex systemic autoimmune disease. Read More

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http://pediatrics.aappublications.org/lookup/doi/10.1542/ped
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http://dx.doi.org/10.1542/peds.2018-1554DOI Listing
January 2019
10 Reads

Adequacy of scoring systems in diagnosing paediatric autoimmune hepatitis: retrospective study using a control group children with Hepatitis B infection.

Acta Paediatr 2019 Jan 31. Epub 2019 Jan 31.

Grigore Alexandrescu Emergency Hospital for Children, Bucharest, Romania.

Aim: To evaluate how correct is made the diagnosis of autoimmune hepatitis (AIH) in children, comparing the adults scoring systems - the 1999 revised scoring system by International Autoimmune Hepatitis Group and the 2007 Simplified Scoring System. The inaccuracies in diagnosis have been analysed.

Methods: The two scoring systems have been applied for 28 children with AIH pre-treatment and 28 with Hepatitis B infection (HBV) - matched by sex and age, all diagnosed between 2010-2017 in an emergency children's hospital in Bucharest, Romania. Read More

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http://dx.doi.org/10.1111/apa.14730DOI Listing
January 2019
4 Reads

Variety of lung involvement in autoimmune liver diseases.

Ter Arkh 2018 Aug;90(8):107-112

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), Faculty of Medicine, Chair of Internal Medicine No.1.

The primary autoimmune liver diseases conventionally include primary biliary cholangitis, primary sclerosing cholangitis and autoimmune hepatitis. Despite of primary autoimmune affection of different parts of the hepatobiliary system, in the recent decades, a lot of data has emerged indicating the presence of extrahepatic manifestations of these diseases, in particular, lung lesions, such as nodular and interstitial changes with possible progression and development of fibrosis and respiratory failure. In case of lungs disease, both pulmonary parenchyma and lung vessels, pleura, and intrathoracic lymph nodes can be involved. Read More

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http://dx.doi.org/https://doi.org/10.26442/terarkh2018908107-112DOI Listing
August 2018
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Important problems in the diagnosis and treatment of autoimmune hepatitis (based on the Russian consensus 2017).

Ter Arkh 2018 Feb;90(2):12-18

S.A. Loginov Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow, Russia.

The analysis of publications devoted to the Russian Consensus on the Diagnostic and Treatment of Autoimmune Hepatitis (AIH), which was considered at the 43rd annual Scientific Session of the CNIIG From Traditions to Innovation (March 4, 2017) is carried out. The presence of clear algorithms and recommendations for the diagnosis and treatment of AIH significantly help the doctor in real clinical practice, but do not exclude a personified approach to the patient. Read More

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http://dx.doi.org/10.26442/terarkh201890212-18DOI Listing
February 2018
1 Read

Clinicopathological impact of Anti Smooth Muscle Antibodies in patients with Nonalcoholic Fatty Liver Disease.

Br J Biomed Sci 2019 Jan 31. Epub 2019 Jan 31.

a Tropical Medicine Department , Mansoura University , Egypt .

Introduction: Previous studies examining the prevalence of serum autoantibodies in patients with NAFLD reported a wide range of prevalence rates depending on the threshold values used for an abnormal titer. We aimed to evaluate the association of anti-smooth muscle antibodies (ASMAbs) with pathological changes including liver fibrosis in NAFLD patients.

Patients And Methods: 124 patients were enrolled and classifed on ASMAbs positive (>1/40) or negative (= or <1/40). Read More

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January 2019

Cardiac arrest in a case of systemic lupus erythematosus and hepatitis-B coinfection: Can be the culprit?

Trop Parasitol 2018 Jul-Dec;8(2):106-109. Epub 2018 Dec 27.

Department of General Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

is one of the most important helminths causing neglected tropical diseases. Its ability to cause autoinfection can lead to chronic infections and hyper infection, especially in autoimmune cases and prove to be highly fatal. We report a case of systemic lupus erythematosus (SLE) having hepatitis-B coinfection, who presented with rash all over the body, recurrent nausea, vomiting, cough, loose stool, and joint pain for 1 month and was later on found to be infected with . Read More

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http://www.tropicalparasitology.org/text.asp?2018/8/2/106/24
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http://dx.doi.org/10.4103/tp.TP_42_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329272PMC
December 2018
2 Reads

HBsAg-negative/anti-HBc-positive patients treated with rituximab: prophylaxis or monitoring to prevent hepatitis B reactivation?

Infection 2019 Jan 28. Epub 2019 Jan 28.

Department I of Internal Medicine, University of Cologne, Kerpener Straße 62, 50937, Cologne, Germany.

Rituximab (RTX) has been classified as a drug associated with a high risk for hepatitis B virus (HBV) reactivation in HbsAg-negative/anti-HBc-positive patients. However, data on frequency of HBV reactivation are limited especially for RTX monotherapy. Several new recommendations for screening, monitoring and prophylactic antiviral treatment have been published recently. Read More

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http://dx.doi.org/10.1007/s15010-019-01271-zDOI Listing
January 2019

Acute-Onset Optic Neuropathy in Wilson's Disease.

Case Rep Ophthalmol 2018 Sep-Dec;9(3):520-525. Epub 2019 Jan 3.

OSU Havener Eye Institute, Department of Ophthalmology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.

Wilson's disease (WD), also known as hepatolenticular degeneration, is a rare autosomal recessive condition of excess copper accumulation that is most commonly associated with hepatic, neurologic, psychiatric, and ocular manifestations. While Kayser-Fleischer rings and sunflower cataracts are well known in WD, visual impairment is very rare. We report the case of a 20-year-old female who presented with acute liver failure and associated monocular vision loss. Read More

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http://dx.doi.org/10.1159/000495744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341316PMC
January 2019
1 Read

[Research advances of autoimmune liver diseases in 2018].

Authors:
Y Chen Q X Wang X Ma

Zhonghua Gan Zang Bing Za Zhi 2019 Jan;27(1):14-17

Department of Gastroenterology, Renji Hospital, Shanghai Jiaotong University School of Medicine;Institute of Digestive Disease, Shanghai 200001, China.

Autoimmune liver disease is a group of hepatobiliary injuries mediated by abnormal immunity. It mainly includes autoimmune hepatitis, primary biliary cholangitis and primary sclerosing cholangitis. Recently, an advancement of diagnostic technology has improved the detection and treatment of autoimmune hepatitis. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1007-3418.2019.01.005DOI Listing
January 2019
2 Reads

Interleukin 35 in Immune-Related Diseases: Protection, or Destruction.

Immunology 2019 Jan 25. Epub 2019 Jan 25.

Department of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

Interleukin 35 (IL-35) is a recently identified heterodimeric cytokine in the IL-12 family. It consists of an IL-12 subunit α chain (P35) and IL-27 subunit Epstein-Barr virus-induced gene 3 (EBI3) β chain. Unlike the other IL-12 family members, it signals through four unconventional receptors: IL-12Rβ2-IL-27Rα, IL-12Rβ2-IL-12Rβ2, IL-12Rβ2-GP130, and GP130-GP130. Read More

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http://dx.doi.org/10.1111/imm.13044DOI Listing
January 2019
1 Read
3.795 Impact Factor

Potential pathogenic mechanisms involved in the association between lichen planus and hepatitis C virus infection.

Exp Ther Med 2019 Feb 16;17(2):1045-1051. Epub 2018 Nov 16.

Department of Microbiology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.

Lichen planus (LP) is an immune-mediated inflammatory disease that particularly affects the skin and mucous membranes. Its etiology remains elusive, however some trigger factors, including viral or bacterial antigens, drugs and metals, have been postulated. There is a higher prevalence of hepatitis C virus (HCV) infection among patients with LP, with some geographical variations. Read More

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http://dx.doi.org/10.3892/etm.2018.6987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327648PMC
February 2019

Hepatotoxicity induced by immune checkpoint inhibitors: a comprehensive review including current and alternative management strategies.

Expert Opin Drug Metab Toxicol 2019 Mar 5;15(3):231-244. Epub 2019 Feb 5.

a Department of Medicine, Division of Gastroenterology and Hepatology , MedStar Georgetown University Hospital , Washington , DC , USA.

Introduction: Immune checkpoint inhibitors (ICIs) block cytotoxic T lymphocyte antigen 4 (CTLA-4) and programmed cell death protein 1 (PD-1)/PD ligand 1 (PD-L1) receptors that control antitumor activities of lymphocytes. While highly efficacious, these drugs have been associated with several immune-related adverse events (irAEs) due to the disruption of self-tolerance. Immune-mediated hepatitis (IMH) usually presents as mild elevations of liver enzymes though it can rarely be associated with life-threatening hepatic injury. Read More

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http://dx.doi.org/10.1080/17425255.2019.1574744DOI Listing
March 2019
1 Read
2.831 Impact Factor

High Seroprevalence of Autoantibodies Typical of Autoimmune Liver Disease in Eastern Ethiopia: Is Chewing of Khat (Catha edulis) a Triggering Factor?

Can J Gastroenterol Hepatol 2018 23;2018:4980597. Epub 2018 Dec 23.

Regional Advisory Unit for Imported and Tropical Diseases, Oslo University Hospital Ullevål, Oslo, Norway.

Background: Recent studies have identified chewing of khat () as an independent risk factor for liver injury; however, the pathogenetic mechanism remains poorly understood. Case series have found markers of autoimmune hepatitis in patients with khat-related liver disease, suggesting that khat chewing might trigger an autoimmune response. The aims of the present study were (i) to assess the prevalence of autoantibodies typical for autoimmune liver diseases in a healthy population in Ethiopia and (ii) to explore the hypothesis that khat usage triggers autoimmunity. Read More

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http://dx.doi.org/10.1155/2018/4980597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323432PMC
December 2018

Fluocinolone acetonide intravitreal implant as a therapeutic option for severe Sjögren's syndrome-related keratopathy: a case report.

J Med Case Rep 2019 Jan 24;13(1):21. Epub 2019 Jan 24.

Department of Ophthalmology, University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstrasse 1, 55131, Mainz, Germany.

Background: In this report, we present the results of a severe case of Sjögren's syndrome-related keratopathy after fluocinolone acetonide 190-μg intravitreal implant (Iluvien®; Alimera Sciences Inc.) therapy.

Case Presentation: A 52-year-old Caucasian woman with Sjögren's syndrome secondary to autoimmune hepatitis and primary sclerosing cholangitis was admitted to our emergency department owing to bilateral corneal ulcers and corneal perforation in the left eye following exposure keratopathy in an artificially induced coma. Read More

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http://dx.doi.org/10.1186/s13256-018-1916-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345050PMC
January 2019
1 Read

Review article: unanswered clinical and research questions in autoimmune hepatitis-conclusions of the International Autoimmune Hepatitis Group Research Workshop.

Aliment Pharmacol Ther 2019 Mar 22;49(5):528-536. Epub 2019 Jan 22.

Hamburg, Germany.

Background: Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease that results in substantial morbidity and mortality with many unanswered clinical and research questions. Improved understanding of disease pathogenesis, including the extra-hepatic manifestations of AIH, may allow targeted treatments with greater efficacy and fewer associated adverse events.

Aim: To identify the spectrum of unanswered clinical and research questions facing care providers in the management of patients with autoimmune hepatitis (AIH). Read More

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http://doi.wiley.com/10.1111/apt.15111
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http://dx.doi.org/10.1111/apt.15111DOI Listing
March 2019
6 Reads

Thrombotic Thrombocytopenic Purpura due to Checkpoint Inhibitors.

Case Rep Hematol 2018 20;2018:2464619. Epub 2018 Dec 20.

The T.W. Lewis Melanoma Center of Excellence, Banner MD Anderson Cancer Center, Gilbert, AZ, USA.

Ipilimumab is a monoclonal antibody that enhances the efficacy of the immune system by targeting a cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), which is a protein receptor that downregulates the immune system. Nivolumab is also a humanized monoclonal antibody that targets another protein receptor that prevents activated T cells from attacking the cancer; this receptor is called programmed cell death 1 (PD-1). The FDA approved ipilimumab combined with nivolumab as a frontline therapy for patients with metastatic melanoma or renal cell carcinoma and as a second-line therapy for patients with microsatellite instability-high (MSI-H) metastatic colon cancer. Read More

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http://dx.doi.org/10.1155/2018/2464619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317083PMC
December 2018
2 Reads

Stopping immunosuppressive treatment in autoimmune hepatitis (AIH): Is it justified (and in whom and when)?

Liver Int 2019 Jan 22. Epub 2019 Jan 22.

Liver Unit, Northern General Hospital, Sheffield Teaching Hospital's NHS Foundation Trust, Sheffield, UK.

Background: Initial treatment of autoimmune hepatitis (AIH) with prednisolone ± azathioprine is based on randomised controlled trials. Many patients receive long-term immunosuppressive treatment to prevent disease relapse; this strategy has a weaker evidence base.

Aim: To consider whether immunosuppressive treatment (IST) withdrawal in AIH is justified and to develop a rationale for patient selection. Read More

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http://doi.wiley.com/10.1111/liv.14051
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http://dx.doi.org/10.1111/liv.14051DOI Listing
January 2019
7 Reads

Tryptophan-kynurenine profile in pediatric autoimmune hepatitis.

Immunol Res 2019 Jan 21. Epub 2019 Jan 21.

Children's Memorial Health Institute, Warsaw, Poland.

The impairment of regulatory T cells (Tregs) is a characteristic feature of autoimmune hepatitis (AIH), and the degradation of tryptophan (Trp) to kynurenine (Kyn), by gamma interferon-induced indoleamine-2,3-dioxygenase-1 (IDO-1), is a central metabolomics check point in the differentiation of Tregs. For this reason, we investigate whether or not Kyn and IDO activity is potentially useful biomarkers in pediatric AIH.Between January 2016 and January 2017, children of AIH type-1 (AIH-1, n = 37), AIH type-2 with liver kidney microsome-1 autoantibodies (AIH-2-LKM-1, n = 8), and autoantibody-negative Wilsons Disease (WD, n = 8) and alpha-1 anti-trypsin deficiency (AATD, n = 10), were enrolled in a cross-sectional survey of Kyn and Trp levels and Kyn/Trp ratios (IDO activity) by HPLC, and neopterin levels by ELISA. Read More

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http://link.springer.com/10.1007/s12026-019-9068-1
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http://dx.doi.org/10.1007/s12026-019-9068-1DOI Listing
January 2019
4 Reads
3.098 Impact Factor

Genital Herpes Zoster as Possible Indicator of HIV Infection.

Acta Dermatovenerol Croat 2018 Dec;26(4):337-338

Associate Professor Suzana Ljubojević Hadžavdić, MD, PhD, Department of Dermatology and Venereology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Šalata 4, 10000 Zagreb, Croatia;

Herpes zoster (HZ) is an acute, cutaneous viral infection caused by the reactivation of varicella-zoster virus (VZV) (1). It is a frequent medical condition with an incidence rate of 2-3 cases per 1000 person/years in the general population and 7-10 cases per 1000 person/years after the age of 50 (1,2). Risk factors and triggers for reactivation of HZV have not yet been determined precisely, but are likely to include malignancies, immune deficiencies, solid organ and bone marrow transplant recipients, autoimmune diseases, psychological conditions, emotional stress, human immunodeficiency virus (HIV) infection, and other patients receiving immunosuppressive therapies (1,3). Read More

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December 2018
7 Reads

Editorial: the role of vitamin D in autoimmune hepatitis-authors' reply.

Aliment Pharmacol Ther 2019 Feb;49(3):343-344

Division of Gastroenterology & Liver Unit, University of Alberta Hospital, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1111/apt.15091DOI Listing
February 2019
1 Read

Editorial: the role of vitamin D in autoimmune hepatitis.

Aliment Pharmacol Ther 2019 Feb;49(3):342-343

Department of Gastroenterology, Gazi Yaşargil Education and Research Hospital, Diyarbakir, Turkey.

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http://dx.doi.org/10.1111/apt.15075DOI Listing
February 2019
1 Read

Anti-CD200 attenuates concanavalin A induced hepatitis via modulating the imbalance of CD4 T lymphocyte differentiation in mice.

Am J Transl Res 2018 15;10(12):4202-4209. Epub 2018 Dec 15.

Department of Anesthesiology, Affiliated Hospital of Guilin Medical University 15 Lequn Rd, Guilin 541001, China.

Hepatitis occurs in critical ill patients with bad morbidity and mortality. It is known that imbalance of Th1 and Th2 lymphocytes differentiations plays a key role in its mechanisms. Recent studies indicated that type 1 membrane glycoprotein CD200 serves as co-inhibitory molecule, negatively regulating the immune response. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325521PMC
December 2018
3.226 Impact Factor

Cold type autoimmune hemolytic anemia- a rare manifestation of infectious mononucleosis; serum ferritin as an important biomarker.

BMC Infect Dis 2019 Jan 18;19(1):68. Epub 2019 Jan 18.

Sri Jayawardanapura General Hospital, Thalapathpitiya, Nugegoda, Western province, Sri Lanka.

Background: Infectious mononucleosis is one of the main manifestations of Epstein - Barr virus, which is characterized by fever, tonsillar-pharyngitis, lymphadenopathy and atypical lymphocytes. Although 60% of patients with IMN develop cold type antibodies, clinically significant hemolytic anemia with a high ferritin level is very rare and validity of serum ferritin as an important biomarker has not been used frequently.

Case Presentation: 18-year-old girl presented with fever, malaise and sore throat with asymptomatic anemia, generalized lymphadenopathy, splenomegaly and mild hepatitis. Read More

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http://dx.doi.org/10.1186/s12879-019-3722-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339345PMC
January 2019
3 Reads

Autoimmune hepatitis in 847 childhood-onset systemic lupus erythematosus population: a multicentric cohort study.

Adv Rheumatol 2018 Dec 13;58(1):43. Epub 2018 Dec 13.

Pediatric Rheumatology Unit, Children's Institute, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.

Objective: To evaluate autoimmune hepatitis (AIH) in a multicenter cohort of childhood-onset systemic lupus erythematosus (cSLE) patients.

Methods: This retrospective multicenter study included 847 patients with cSLE, performed in 10 Pediatric Rheumatology services of São Paulo state, Brazil. AIH was defined according to the International Autoimmune Hepatitis Group criteria (IAHGC). Read More

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http://dx.doi.org/10.1186/s42358-018-0043-7DOI Listing
December 2018
3 Reads

[Prevalence and clinical features of non-alcoholic steatohepatitis in a hypertensive population].

Hipertens Riesgo Vasc 2019 Jan 14. Epub 2019 Jan 14.

Teoría de la Señal y las Comunicaciones y Sistemas Telemáticos y Computación, Universidad Rey Juan Carlos, Móstoles, Madrid, España.

Objective: Non-alcoholic fatty liver is a chronic liver disease in which fat is deposited in the liver, causing an inflammation called non-alcoholic steatohepatitis (NASH), and fibrosis. NASH is associated with metabolic syndrome (MS) and other cardiovascular risk factors. The aim of this study was to analyse the epidemiological features of NASH within a hypertensive population, with a high prevalence of MS, and to determine the features related to NASH. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18891837183009
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http://dx.doi.org/10.1016/j.hipert.2018.10.001DOI Listing
January 2019
6 Reads

Autoimmune hepatitis and complexities in management.

Frontline Gastroenterol 2019 Jan 12;10(1):77-87. Epub 2018 Aug 12.

Centre for Liver Research, NIHR Birmingham Biomedical Research Centre, University of Birmingham, Birmingham, UK.

Autoimmune hepatitis (AIH) is a rare heterogenous immune-mediated liver disease that for the majority has effective therapy, usually resulting in excellent prognosis. Treatment is based on immunosuppression using standard therapy with corticosteroids and azathioprine. Second-line therapeutic options exist for those who are non-responders ('difficult to treat AIH') or intolerant to standard therapy; however, their use is not standardised, and in addition, there is vast variation in practice and efficacy. Read More

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http://fg.bmj.com/lookup/doi/10.1136/flgastro-2018-101015
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http://dx.doi.org/10.1136/flgastro-2018-101015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319158PMC
January 2019
3 Reads

A review of the utility of tacrolimus in the management of adults with autoimmune hepatitis.

Scand J Gastroenterol 2019 Jan 16:1-5. Epub 2019 Jan 16.

b Abbott Northwestern Hospital , Minneapolis , MN, USA.

Background: There is paucity of data on alternative drug therapies for patients with autoimmune hepatitis (AIH). Tacrolimus (TAC) is a promising salvage agent. We present a review of TAC therapy in AIH patients. Read More

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https://www.tandfonline.com/doi/full/10.1080/00365521.2018.1
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http://dx.doi.org/10.1080/00365521.2018.1551498DOI Listing
January 2019
11 Reads

POGLUT1, the putative effector gene driven by rs2293370 in primary biliary cholangitis susceptibility locus chromosome 3q13.33.

Sci Rep 2019 Jan 14;9(1):102. Epub 2019 Jan 14.

Clinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Omura, Japan.

Primary biliary cholangitis (PBC) is a chronic and cholestatic autoimmune liver disease caused by the destruction of intrahepatic small bile ducts. Our previous genome-wide association study (GWAS) identified six susceptibility loci for PBC. Here, in order to further elucidate the genetic architecture of PBC, a GWAS was performed on an additional independent sample set, then a genome-wide meta-analysis with our previous GWAS was performed based on a whole-genome single nucleotide polymorphism (SNP) imputation analysis of a total of 4,045 Japanese individuals (2,060 cases and 1,985 healthy controls). Read More

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http://dx.doi.org/10.1038/s41598-018-36490-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331557PMC
January 2019
3 Reads

Role of Biologics in the Development of Autoimmune Hepatitis: A Review.

J Clin Transl Hepatol 2018 Dec 15;6(4):402-409. Epub 2018 Dec 15.

Department of Medicine, Division of Gastroenterology-Hepatology, University of Connecticut Health Center, Farmington, CT, USA.

Autoimmune hepatitis (AIH) is a cause of chronic, immune-mediated liver injury which without treatment may progress to end-stage liver disease. The disease state, characterized by elevations in liver enzymes, autoantibodies, and interface hepatitis on histology, has been noted to be induced by a wide range of insults. Medications, most commonly minocycline and nitrofurantoin, have long been established as potential inducers of AIH. Read More

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http://www.xiahepublishing.com/2310-8819/ArticleFullText.asp
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http://dx.doi.org/10.14218/JCTH.2018.00039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328740PMC
December 2018
4 Reads

Autoimmune Hepatitis with Concomitant Idiopathic Thrombocytopenic Purpura Diagnosed by Transjugular Liver Biopsy.

Case Reports Hepatol 2018 9;2018:5305691. Epub 2018 Dec 9.

Department of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan, Fukuoka 814-0180, Japan.

Patients with autoimmune hepatitis (AIH) may sometimes have concomitant idiopathic thrombocytopenic purpura (ITP). Severe thrombocytopenia in ITP interferes with percutaneous liver biopsy for pathological diagnosis of AIH. Here, we report a case of AIH with ITP in a 63-year-old woman. Read More

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https://www.hindawi.com/journals/crihep/2018/5305691/
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http://dx.doi.org/10.1155/2018/5305691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304620PMC
December 2018
5 Reads

Autoimmune hepatitis: Appraisal of current treatment guidelines.

World J Hepatol 2018 Dec;10(12):911-923

Division of Gastroenterology and Hepatology, Department of Medicine, State University of New York, Upstate Medical University, Syracuse, NY 13202, United States.

Autoimmune hepatitis affects patients of all ages and gender, across all geographic regions. Although still rare, its incidence and prevalence are increasing. Genetic predisposition conveyed by human leucocyte antigen is a strong risk factor for the disease and may be responsible in part for the wide variation in presentation in different geographic regions. Read More

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http://dx.doi.org/10.4254/wjh.v10.i12.911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323516PMC
December 2018

[Clinical and pathological characteristics and outcome of 46 children with autoimmune hepatitis].

Zhonghua Er Ke Za Zhi 2019 Jan;57(1):40-45

Pediatric Liver Diseases Treatment and Research Center, Fifth Medical Center, General Hospital of the People's Liberation Army (PLA), Beijing 100039, China.

To review and analyze the clinical and pathological data of children with autoimmune hepatitis (AIH). Medical records of 46 patients hospitalized in Pediatric Liver Diseases Treatment and Research Center, Fifth Medical Center, General Hospital of People's Liberation Army(PLA) from April 2012 to April 2018 were extracted. Medical data included type of AIH, clinical manifestations, biochemical parameters, liver biopsy results, and outcomes of treatment were analyzed retrospectively. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2019.01.010DOI Listing
January 2019
3 Reads

Predniso(lo)ne Dosage and Chance of Remission in Patients With Autoimmune Hepatitis.

Clin Gastroenterol Hepatol 2019 Jan 5. Epub 2019 Jan 5.

Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

Background & Aims: Patients with autoimmune hepatitis (AIH) commonly receive induction therapy with predniso(lo)ne followed by maintenance therapy with azathioprine. European Association for Study of the Liver clinical practice guidelines advise a predniso(lo)ne dose range of 0.50-1 mg/kg/day, which leaves room for practice variation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15423565193000
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http://dx.doi.org/10.1016/j.cgh.2018.12.035DOI Listing
January 2019
13 Reads

Editorial: Genetics of cholangiopathies.

Curr Opin Gastroenterol 2019 Mar;35(2):63-64

Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine (CRSA), Assistance Publique-Hôpitaux de Paris, Reference Center for Inflammatory Biliary Diseases and Autoimmune Hepatitis (CRMR, MIVB-H), Paris, France.

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http://Insights.ovid.com/crossref?an=00001574-201903000-0000
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http://dx.doi.org/10.1097/MOG.0000000000000510DOI Listing
March 2019
2 Reads