10,205 results match your criteria Autoimmune Hepatitis


Interleukin-35 modulates the balance between viral specific CD4CD25CD127 regulatory T cells and T helper 17 cells in chronic hepatitis B virus infection.

Virol J 2019 Apr 16;16(1):48. Epub 2019 Apr 16.

Department of Hepatopancreatobiliary Medicine, The Second Hospital, Jilin University, No. 218 Ziqiang Street, Nanguan District, Changchun, 130041, Jilin Province, China.

Background: Interleukin (IL)-35 regulates imbalance between regulatory T cells (Tregs) and T helper (Th) 17 cells, leading to an important modulator in autoimmune disorder, cancer, and infectious diseases. Our previous study revealed an immunosuppressive activity of IL-35 in chronic hepatitis B virus (HBV) infection. Thus, the aim of the current study was to investigate the role of regulatory function of IL-35 to viral specific Tregs/Th17 cells balance in chronic HBV infection. Read More

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http://dx.doi.org/10.1186/s12985-019-1158-0DOI Listing

High frequency of concomitant food allergy development and autoantibody formation in children who have undergone liver transplantation.

Transplantation 2019 Apr 8. Epub 2019 Apr 8.

Department of Pediatric Gastroenterology, Hepatology and Nutrition, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden.

Background: Allergy and other immune-mediated diseases are more frequently reported in children who have undergone liver transplantation. Furthermore, autoantibodies are also prevalent, suggesting a state of immune dysregulation in these patients. Whether or not these processes occur simultaneously in the same individual has not been studied previously. Read More

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http://dx.doi.org/10.1097/TP.0000000000002751DOI Listing
April 2019
1 Read

Steroid free treatment in autoimmune hepatitis: Is azathioprine monotherapy truly a viable option to obtain remission?

J Pediatr 2019 Apr 11. Epub 2019 Apr 11.

Pediatric Hepatology and Liver Transplantation, ISMETT-University of Pittsburgh Medical Center Italy, Palermo, Italy.

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http://dx.doi.org/10.1016/j.jpeds.2019.03.026DOI Listing

Beneficial response to mycophenolate mofetil by patients with autoimmune hepatitis who have failed standard therapy, is predicted by older age and lower immunoglobulin G and INR levels.

Aliment Pharmacol Ther 2019 Apr 11. Epub 2019 Apr 11.

Sydney, NSW.

Background: Mycophenolate mofetil is a commonly used salvage therapy for patients with autoimmune hepatitis (AIH).

Aim: To evaluate the predictors of response to mycophenolate rescue therapy to facilitate clinical decision making.

Methods: We performed a retrospective observational cohort study of AIH patients managed in 17 major Australian liver centres who received mycophenolate after an inadequate response or intolerance to corticosteroids with/without thiopurine(s). Read More

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http://dx.doi.org/10.1111/apt.15248DOI Listing
April 2019
5.727 Impact Factor

Hydroxychloroquine treatment during pregnancy in lupus patients is associated with lower risk of preeclampsia.

Lupus 2019 Apr 10:961203319843343. Epub 2019 Apr 10.

1 Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background: Hydroxychloroquine (HCQ) is regarded as a mainstay in the treatment of systemic lupus erythematosus (SLE) because of its efficacy in preventing flares, achieving remission, and reducing overall mortality. However, the impact of HCQ on pregnancy outcomes remains controversial.

Objective: We aimed to investigate the effect of HCQ on pregnancy outcomes in patients with SLE. Read More

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http://dx.doi.org/10.1177/0961203319843343DOI Listing
April 2019
4 Reads

Emerging novel treatments for autoimmune liver diseases.

Authors:
Atsushi Tanaka

Hepatol Res 2019 Apr 10. Epub 2019 Apr 10.

School of Medicine, Teikyo University, Tokyo, Japan.

The etiology of autoimmune liver diseases, such as autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC), still remains largely unknown and no therapeutic agents that are able to "cure" the disease have been developed. While corticosteroids for AIH and ursodeoxycholic acid (UDCA) for PBC have been shown to significantly improve liver transplantation (LT)-free survival and are recommended as first-line drugs, treatment strategies for patients who exhibit incomplete response to these drugs have not yet been fully established. No drug is significantly associated with long LT-free survival in PSC patients. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/hepr.13347
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http://dx.doi.org/10.1111/hepr.13347DOI Listing
April 2019
3 Reads

Jaundice and anaemia as presenting features of an incomplete autoimmune polyglandular syndrome type II.

BMJ Case Rep 2019 Apr 8;12(4). Epub 2019 Apr 8.

Department of General Medicine, R.G. Kar Medical College and Hospital, Kolkata, India.

The coexistence of adrenal failure with either autoimmune thyroid disease and/or type 1 diabetes is defined as autoimmune polyglandular syndrome (APS) type 2 or Schmidt's syndrome. Vitiligo, hypergonadotropic hypogonadism, chronic autoimmune hepatitis, alopecia, pernicious anaemia and seronegative arthritis may also be present. We present a case of 45-year-old Indian man with progressive jaundice and asthenia for 3 months. Read More

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http://dx.doi.org/10.1136/bcr-2018-228490DOI Listing
April 2019
1 Read

Clinical course and mortality by etiology of liver cirrhosis in Sweden: a population based, long-term follow-up study of 1317 patients.

Aliment Pharmacol Ther 2019 Apr 8. Epub 2019 Apr 8.

Department of Clinical Sciences, Lund University, Lund, Sweden.

Background: Liver cirrhosis is characterized by a silent phase until decompensation, which is defined by ascites, bleeding from esophageal varices or hepatic encephalopathy.

Aim: We compare the clinical course, patterns of survival and causes of death by etiology during long-term follow-up in a large population-based cohort of patients with incident cirrhosis.

Material And Methods: We used population-based medical registries for a cohort study of patients with liver cirrhosis diagnosed January 2001 to December 2010, in the Scania region of Sweden. Read More

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http://doi.wiley.com/10.1111/apt.15255
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http://dx.doi.org/10.1111/apt.15255DOI Listing
April 2019
8 Reads

Long-term antiviral hepatitis C treatment associated with Rods and Ring Cytoplasmic antibodies.

Med Pharm Rep 2019 Jan 15;92(1):87-90. Epub 2019 Jan 15.

Molecular Sciences, Microbiology Department, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Aim: Clinical description of a patient diagnosed with chronic hepatitis C virus infection, which associated a rare anti-cytoplasmic pattern, known as "Rods and Ring".

Method: Clinical case report.

Results: A 76-year old female patient with chronic hepatitis C virus infection under treatment for several months with pegylated Interferon-Ribavirin (started eight months ago) presented for clinical and biological evaluation of the therapeutic response. Read More

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http://dx.doi.org/10.15386/cjmed-996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448485PMC
January 2019

Polyarteritis Nodosa Neurologic Manifestations.

Neurol Clin 2019 May 16;37(2):345-357. Epub 2019 Mar 16.

Vasculitides and Scleroderma, Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, Université Paris Descartes, 27, rue Fg Saint-Jacques, Paris 75679 Cedex 14, France. Electronic address:

Polyarteritis nodosa (PAN) is a necrotizing vasculitis affecting medium-sized vessels whose main manifestations are weight loss, fever, peripheral neuropathy, renal, musculoskeletal, gastrointestinal tract and/or cutaneous involvement(s), hypertension and/or cardiac failure. Peripheral neuropathy is one of the most frequent and earliest symptoms, affecting 50% to 75% of PAN patients. Central nervous system involvement affects only 2% to 10% of PAN patients, often late during the disease course. Read More

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http://dx.doi.org/10.1016/j.ncl.2019.01.007DOI Listing
May 2019
1 Read

4-Methylcoumarin-[5,6-g]-hesperetin attenuates inflammatory responses in alcoholic hepatitis through PPAR-γ activation.

Toxicology 2019 Apr 3;421:9-21. Epub 2019 Apr 3.

The Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Anhui Province, China; The Key Laboratory of Anti-Inflammatory of Immune Medicines, Ministry of Education, China; Institute for Liver Diseases of Anhui Medical University, China. Electronic address:

4-Methylcoumarin-[5,6-g]-hesperetin (4-MCH) is a hesperidin derivative produced by the structural modification of hesperetin. Alcoholic hepatitis (AH) is the origin of many serious liver diseases that are accompanied by hepatic inflammation. In this study, we detected the anti-inflammatory activity of 4-MCH in EtOH fed mice and examined the potential molecular mechanism of this activity. Read More

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http://dx.doi.org/10.1016/j.tox.2019.04.004DOI Listing
April 2019
1 Read
3.621 Impact Factor

The intriguing chemistry and biology of soraphens.

Nat Prod Rep 2019 Apr 5. Epub 2019 Apr 5.

Department of Chemical Biology, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany. and Center of Biomolecular Drug Research (BMWZ), Leibniz University, 30159 Hannover, Germany and German Center for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Germany.

Covering: up to the end of 2018Soraphens are a class of polyketide natural products discovered from the myxobacterial strain Sorangium cellulosum. The review is intended to provide an overview on the biosynthesis, chemistry and biological properties of soraphens, that represent a prime example to showcase the value of natural products as tools to decipher cell biology, but also to open novel therapeutic options. The prototype soraphen A is an inhibitor of acetyl coenzyme A carboxylase (ACC1/2), an enzyme that converts acetyl-CoA to malonyl-CoA and thereby controls essential cellular metabolic processes like lipogenesis and fatty acid oxidation. Read More

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http://dx.doi.org/10.1039/c9np00008aDOI Listing
April 2019
1 Read
10.107 Impact Factor

Primary biliary cholangitis with contemporary presence of anti-mithocondrial and anti-rods and rings autoantibodies: literature first case.

Authors:
Roberto Assandri

Gastroenterol Hepatol Bed Bench 2019 ;12(1):76-82

Clinical Investigation Laboratory, ASST Crema, Largo Ugo Dossena- Crema, Cremona, Italy.

Primary biliary cholangitis, previously known as primary biliary cirrhosis (PBC), is the most common autoimmune diseases of the liver (ALD). Patients with PBC may present with typical biliary pattern symptoms. Also the presence of anti-mitochondrial autoantibodies (AMAs) is the laboratory hallmark of PBC, which molecular target antigens are members of 2-oxoacid dehydrogenase complex of enzymes. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441490PMC
January 2019
6 Reads

Acute myocardial infarction and renal dysfunction due to chronic extreme anemia (hemoglobin 2.5 g/dL) in immune thrombocytopenia.

Proc (Bayl Univ Med Cent) 2018 Oct 23;31(4):508-510. Epub 2018 Oct 23.

Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at HoustonHoustonTexas.

Immune thrombocytopenic purpura (ITP) is an acquired thrombocytopenia where autoantibodies are generated against platelet antigens. Primary ITP is often idiopathic, whereas secondary ITP has many potential causes, including drug induced, infection related (human immunodeficiency virus, hepatitis C), leukemias, or autoimmune such as systemic lupus erythematosus. ITP is a common cause of thrombocytopenia in asymptomatic individuals, where evidence of bleeding may be minor or absent. Read More

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http://dx.doi.org/10.1080/08998280.2018.1499317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413974PMC
October 2018
2 Reads

Liver Diseases During Pregnancy.

Clin Liver Dis 2019 May 26;23(2):345-361. Epub 2019 Feb 26.

Section of Hepatology, Division of Digestive Diseases, Department of Internal Medicine, Rush University Medical Center, 1725 West Harrison Street, Suite 319, Chicago, IL 60612, USA. Electronic address:

Liver diseases during pregnancy pose a unique clinical challenge because they can affect the lives of both the mother and unborn child. Although severe liver disease is rare, pregnancy-related liver disease affects approximately 3% of pregnancies and can be fatal. Timely recognition and diagnosis are essential in order to institute appropriate management strategies. Read More

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http://dx.doi.org/10.1016/j.cld.2018.12.013DOI Listing
May 2019
4 Reads

Rheumatologic Diseases and the Liver.

Clin Liver Dis 2019 May 8;23(2):247-261. Epub 2019 Mar 8.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Howard University Hospital and College of Medicine, 2041 Georgia Avenue Northwest, Suite 5C02, Washington, DC 20060, USA. Electronic address:

A variety of rheumatologic disorders may affect the liver. There is a significant epidemiologic, genetic, and immunologic overlap between immune-mediated rheumatologic disorders and autoimmune liver diseases. There is an increased frequency of autoimmune liver diseases, such as primary biliary cholangitis, autoimmune hepatitis, primary sclerosing cholangitis, or overlap syndrome, in patients with systemic lupus erythematosus, rheumatoid arthritis, Sjögren syndrome, systemic sclerosis, vasculitis, and other immune-related diseases. Read More

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http://dx.doi.org/10.1016/j.cld.2018.12.007DOI Listing
May 2019
1 Read

Hepatic Complications of Inflammatory Bowel Disease.

Clin Liver Dis 2019 May 26;23(2):191-208. Epub 2019 Feb 26.

Division of Gastroenterology and Hepatology, University of Miami Miller School of Medicine, 1120 Northwest 14 Street #1115, Miami, FL 33136, USA.

Hepatobiliary disorders are commonly encountered in patients with inflammatory bowel disease (IBD). Although primary sclerosing cholangitis is the stereotypical hepatobiliary disorder associated with IBD, other diseases, including autoimmune hepatitis and nonalcoholic fatty liver disease, also are encountered in this population. Several agents used for treatment of IBD may cause drug-induced liver injury, although severe hepatotoxicity occurs infrequently. Read More

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http://dx.doi.org/10.1016/j.cld.2018.12.003DOI Listing
May 2019
1 Read

Expression and significance of Th17 cells and related factors in patients with autoimmune hepatitis.

Authors:
Jihong An

Comb Chem High Throughput Screen 2019 Apr 2. Epub 2019 Apr 2.

Department of Infectious Diseases, Inner Mongolia People's Hospital, Inner Mongolia 010017. China.

Aim And Objective: This study aims to investigate the expression and clinical significance of Th17 cells and related factors in peripheral blood of patients with autoimmune hepatitis (AIH).

Materials And Methods: A retrospective selection of 100 patients with AIH were included as study group, and 100 healthy volunteers in the outpatient clinic were selected as the control group. The levels of IL-17, IL-6, IL-21 and TNF-α in peripheral blood of all subjects were detected by enzyme-linked immunosorbent assay and the frequency of Th17 cells and Treg cells was detected by flow cytometry. Read More

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http://dx.doi.org/10.2174/1386207322666190402160455DOI Listing
April 2019
3 Reads

Autoimmune Hepatitis and Stellate Cells; an Insight into the Role of Autophagy.

Curr Med Chem 2019 Apr 2. Epub 2019 Apr 2.

Department of Pathology, Medical school of Shiraz University,Shiraz University of Medical Sciences,Shiraz. Iran.

Autoimmune hepatitis is a necroinflammatory process of liver, featuring interface hepatitis by T cells, macrophages and plasma cells that invade to periportal parenchyma. In this process a variety of cytokines is secreted and liver tissue undergoes fibrogenesis, that cause apoptosis of hepatocytes. Autophagy is a complementary mechanism for restraining intracellular pathogens to which the innate immune system does not provide an efficient endocytosis. Read More

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http://dx.doi.org/10.2174/0929867326666190402120231DOI Listing
April 2019
1 Read
3.853 Impact Factor

Liver Fibrosis Helps to Distinguish Autoimmune Hepatitis from DILI with Autoimmune Features: A Review of Twenty Cases.

J Clin Transl Hepatol 2019 Mar 9;7(1):21-26. Epub 2019 Jan 9.

Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL, USA.

Drug-induced liver injury with autoimmune features (AI-DILI) mimics the clinical presentation, and laboratory and pathologic features of idiopathic autoimmune hepatitis (AIH). We aimed to identify histopathologic hallmarks to differentiate these entities. All liver biopsies archived for the past 10 years were reviewed retrospectively to identify cases of recently detected liver injury associated with predominantly lymphoplasmacytic interphase hepatitis, positive markers for liver autoimmunity, and negative tests for viral hepatitis. Read More

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http://dx.doi.org/10.14218/JCTH.2018.00053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441645PMC
March 2019
4 Reads

Ectonucleotidases in Intestinal and Hepatic Inflammation.

Front Immunol 2019 19;10:507. Epub 2019 Mar 19.

Department of Anesthesia, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.

Purinergic signaling modulates systemic and local inflammatory responses. Extracellular nucleotides, including eATP, promote inflammation, at least in part via the inflammasome upon engagement of P2 purinergic receptors. In contrast, adenosine generated during eATP phosphohydrolysis by ectonucleotidases, triggers immunosuppressive/anti-inflammatory pathways. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433995PMC
March 2019
3 Reads

Checkpoint Inhibitors.

Dtsch Arztebl Int 2019 Feb;116(8):119-126

Department of Dermatology, University Hospital Erlangen-Nürnberg; Department of Internal Medicine II, University Hospital, Ludwig-Maximilians-University (LMU )Munich; Department of Medicine 3, University Hospital Erlangen-Nürnberg; Department of Medicine 1, University Hospital Erlangen-Nürnberg; Clinic for Dermatology, Essen University Hospital, University of Duisburg-Essen.

Background: Treatment with checkpoint inhibitors such as anti-programmed death-1 (anti-PD-1), anti-PD-ligand 1 (anti-PD-L1), and anti-cytotoxic T-lymphocyte antigen-4 (anti-CTLA-4) antibodies can prolong the survival of cancer patients, but it also induces autoimmune side effects in 86-96% of patients by activating the immune system. In 17-59% of patients, these are severe or even life-threatening.

Methods: This review is based on pertinent articles retrieved by a search in PubMed and on an evaluation of a side-effect registry. Read More

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http://dx.doi.org/10.3238/arztebl.2019.0119DOI Listing
February 2019
2 Reads

The Changing Landscape of Management of Metastatic Renal Cell Carcinoma: Current Treatment Options and Future Directions.

Curr Treat Options Oncol 2019 Apr 1;20(5):41. Epub 2019 Apr 1.

Department of Medical Oncology and Experimental Therapeutics, City of Hope Comprehensive Cancer Center, 1500 East Duarte Road, Duarte, CA, 91010, USA.

Opinion Statement: For the practicing clinician, the dilemma becomes how most appropriate to sequence the aforementioned regimens. It is challenging to be dogmatic, as there are no comparative studies juxtaposing novel front-line options directly-all of the available studies utilize a comparator arm of sunitinib. With this in mind, the selection of front-line therapy with a patient with mRCC should involve a thorough discussion of both efficacy and safety of available options. Read More

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http://dx.doi.org/10.1007/s11864-019-0638-1DOI Listing

Non-contrast MR lymphography of the lymphatic system of the liver.

Eur Radiol 2019 Apr 1. Epub 2019 Apr 1.

Faculté de Médecine Pierre et Marie Curie and Department of Radiology, Saint-Antoine Hospital, Assistance Publique-Hôpitaux de Paris, Sorbonne Université, 184 Rue du Faubourg Saint-Antoine, 75012, Paris, France.

This review shows the images obtained with non-contrast MR lymphography in different pathologic conditions affecting the liver. Non-contrast MR lymphography is obtained with a free-breathing 3D high spatial resolution fast-recovery fast spin-echo sequence similar to that used for 3D MR cholangiopancreatography. The liver is the largest lymph-producing organ generating approximately half of the body's lymphatic fluid and is the most important part of the lymphatic system from a functional point of view. Read More

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http://dx.doi.org/10.1007/s00330-019-06151-6DOI Listing
April 2019
3 Reads

Severe cholestasis due to azathioprine in Behcet's disease.

BMJ Case Rep 2019 Mar 31;12(3). Epub 2019 Mar 31.

Department of pathology, Faculty of Medicine, Mersin University, Kahramanmaras, Turkey.

Azathioprine (AZA) is an immunosuppressive drug that is widely used in the treatment of autoimmune diseases. Although AZA is used widely, many studies reported that AZA-related hepatotoxicity is rather rare. We aimed to present a case with severe cholestatic hepatitis due to AZA use for Behcet's disease. Read More

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http://dx.doi.org/10.1136/bcr-2018-226340DOI Listing
March 2019
1 Read

An increase trend in the prevalence and male-to-female ratio of primary biliary cholangitis, autoimmune hepatitis, and primary sclerosing cholangitis in Japan.

Hepatol Res 2019 Apr 1. Epub 2019 Apr 1.

Faculty of Medical Technology, Teikyo University, Tokyo, Japan.

Background And Aim: Autoimmune liver diseases (AILD) including autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC) impose a significant burden on public health, and it is important to estimate prevalence of AILD. We conducted a nationwide, hospital-based, epidemiological survey of AIH, PBC, and PSC, and compared the results with those from previous surveys.

Method: We randomly selected healthcare facilities used in the survey from a list of all facilities in Japan. Read More

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http://dx.doi.org/10.1111/hepr.13342DOI Listing
April 2019
1 Read

Metabolomics profiling in a mouse model reveals protective effect of Sancao granule on Con A-Induced liver injury.

J Ethnopharmacol 2019 Mar 28:111838. Epub 2019 Mar 28.

Department of Pharmacy, 302 Military Hospital of China, Beijing, China. Electronic address:

Ethnopharmacological Relevance: Sancao granule (SCG) is a traditional Chinese herb formula, which has been used for autoimmune liver disease for decades. Previous study demonstrated that there was an exactly therapeutic effect of SCG on autoimmune hepatitis (AIH) by improving liver function and alleviating the clinical symptoms. However, studies of the mechanism by which SCG alleviates Con A-induced liver injury (CILI) should be complemented. Read More

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http://dx.doi.org/10.1016/j.jep.2019.111838DOI Listing
March 2019
1 Read
2.998 Impact Factor

Development and validation of a new simplified diagnostic scoring system for pediatric autoimmune hepatitis.

Dig Liver Dis 2019 Mar 27. Epub 2019 Mar 27.

Sant Joan de Déu Hospital (HSJD), Department of Pediatric Gastroenterology, Hepatology and Nutrition, Barcelona, Spain; HSJD-HVH Comprehensive Unit of Complex Hepatology and Pediatric Liver Transplantation, Barcelona, Spain. Electronic address:

Background: Children with autoimmune hepatitis (AIH) often exhibit particular features. Accordingly, seven pediatric-specific criteria have been proposed.

Aim: To develop a prediction model based on them, transform it into a scoring system and study its accuracy. Read More

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http://dx.doi.org/10.1016/j.dld.2019.02.018DOI Listing
March 2019
1 Read

Development of autoimmune hepatitis after influenza vaccination; trigger or killer?

Clin Res Hepatol Gastroenterol 2019 Mar 26. Epub 2019 Mar 26.

Center for the Study and Treatment of Autoimmune Diseases of the Liver and Biliary System, Policlinico di Sant'Orsola, Bologna, Italy; Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum, University of Bologna, Bologna, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.clinre.2019.02.007DOI Listing
March 2019
1 Read

Minimally invasive assessment of hepatic function in children with indocyanine green elimination: a validation study.

Scand J Gastroenterol 2019 Mar 29:1-7. Epub 2019 Mar 29.

e Department of Clinical Physiology, Nuclear Medicine and PET , Copenhagen University Hospital, Rigshospitalet , Copenhagen Ø , Denmark.

Objectives: Pediatric liver disease (PLD) covers a variety of etiologies and severities, from mild temporary illness to diseases with fatal outcomes. There is a demand for minimally invasive and reliable measures for assessment of the severity of PLD. Indocyanine green (ICG) elimination kinetics to estimate hepatic function has been used in adults for decades, however, due to invasiveness, the use in PLD is still limited. Read More

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http://dx.doi.org/10.1080/00365521.2019.1591497DOI Listing
March 2019
1 Read

Factors influencing serum chemerin and kallistatin concentrations in patients with alcohol-induced liver cirrhosis.

Ann Agric Environ Med 2019 Mar 3;26(1):143-147. Epub 2019 Jan 3.

Department of Nephrology, Medical University, Lublin, Poland.

Introduction: In Poland, an increasing number of patients are hospitalized due to liver diseases. One of the common liver diseases is cirrhosis, which can be caused by alcohol, viral hepatitis, autoimmune processes and metabolic diseases.

Material And Methods: The study included 99 patients with alcoholic cirrhosis from the Lublin region of Eastern Poland. Read More

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http://dx.doi.org/10.26444/aaem/100536DOI Listing

Letter: vitamin D deficiency and autoimmune hepatitis - from research to treatment.

Aliment Pharmacol Ther 2019 Apr;49(8):1103

Department of Cardiology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China.

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http://dx.doi.org/10.1111/apt.15147DOI Listing
April 2019
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Letter: vitamin D deficiency and autoimmune hepatitis - from research to treatment-authors' reply.

Aliment Pharmacol Ther 2019 Apr;49(8):1104-1105

Division of Gastroenterology & Liver Unit, University of Alberta Hospital, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1111/apt.15154DOI Listing
April 2019
1 Read

Acute liver injury induced by red yeast rice supplement.

BMJ Case Rep 2019 Mar 25;12(3). Epub 2019 Mar 25.

Henry Ford Health System, Detroit, Michigan, USA.

A 64-year-old woman previously taking no medications presented with acute hepatitis 6 weeks after starting a red yeast rice supplement to decrease her cholesterol. Red yeast rice is commonly used for hyperlipidaemia as an alternative to statins as it contains monacolin K, the same active chemical in lovastatin. Infectious, toxic and autoimmune causes for injury were ruled out, and liver biopsy was consistent with drug induced liver injury. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22796
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http://dx.doi.org/10.1136/bcr-2018-227961DOI Listing
March 2019
9 Reads

Myeloid-derived suppressor cells expansion is closely associated with disease severity and progression in HBV-related acute-on-chronic liver failure.

J Med Virol 2019 Mar 24. Epub 2019 Mar 24.

Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.

Dysregulation of the host immune responses induced by host hepatitis B virus (HBV) interactions has been observed in acute-on-chronic liver failure (ACLF). Myeloid-derived suppressor cells (MDSCs), well known for their immunomodulatory properties, can suppress T-cell function by regulating the expression of CD3 ζ chain in cancer and autoimmune/infectious diseases while rarely have been studied in ACLF. In this study, MDSCs, CD4 /CD8 T cells, and CD3 ζ chain were analyzed by flow cytometry in peripheral blood mononuclear cells obtained from HBV-related ACLF patients, chronic hepatitis B (CHB) patients and healthy controls. Read More

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http://dx.doi.org/10.1002/jmv.25466DOI Listing
March 2019
1 Read

Ductular reaction in acute onset autoimmune hepatitis.

Hepatology 2019 Mar 22. Epub 2019 Mar 22.

Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.

We read with interest the review article by Sato, et al. [1] who summarized types, mechanisms and pathways of ductular reaction (DR) in liver diseases. This concise and comprehensive review is valuable for understanding DR in liver diseases. Read More

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http://dx.doi.org/10.1002/hep.30621DOI Listing
March 2019
1 Read

Acute severe autoimmune hepatitis - Corticosteroids or liver transplantation?

Liver Transpl 2019 Mar 22. Epub 2019 Mar 22.

Institute of Liver Studies, King's College Hospital, London, SE5 9RS, United Kingdom.

Acute severe presentations of autoimmune hepatitis (AIH) represent a challenge for the transplant community. As an entity, it is poorly characterized and there is weak evidence base to guide diagnosis and treatment. Early identification of acute severe AIH (AS-AIH) is key, as it determines the initiation of corticosteroids which can be life-saving. Read More

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http://dx.doi.org/10.1002/lt.25451DOI Listing
March 2019
1 Read

A case of severe rhabdomyolysis associated with secondary adrenal insufficiency and autoimmune hepatitis.

BMJ Case Rep 2019 Mar 20;12(3). Epub 2019 Mar 20.

General Medicine, Flinders Medical Centre, Bedford Park, South Australia, Australia.

Rhabdomyolysis is a serious and life-threatening condition which has many established causes including endocrine disturbances. Of those, thyroid, adrenal and pituitary deficiencies are the most commonly seen. Most cases of rhabdomyolysis with adrenal insufficiency that have been reported have been primary. Read More

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http://dx.doi.org/10.1136/bcr-2018-227343DOI Listing
March 2019
2 Reads

Glycogenic hepatopathy as a cause of severe deranged liver enzymes in a young patient with type 1 diabetes mellitus.

BMJ Case Rep 2019 Mar 20;12(3). Epub 2019 Mar 20.

Department of Medicine and Research Laboratory of Internal Medicine, University Hospital of Larissa, Larissa, Greece.

Glycogenic hepatopathy (GH) is a rare complication of poorly controlled type 1 diabetes mellitus (T1DM). We present a 19-year-old woman with T1DM and autoimmune thyroiditis who admitted to our department because of abrupt onset intermittent abdominal pain in the right upper quadrant accompanied by laboratory evidence of acute anicteric hepatitis. Physical examination revealed significant hepatomegaly but the common imagining studies were negative. Read More

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http://dx.doi.org/10.1136/bcr-2018-228524DOI Listing
March 2019
2 Reads

A C-Steroidal Glycoside from Attenuates Concanavalin A-Induced Liver Injury in Mice.

Molecules 2019 Mar 19;24(6). Epub 2019 Mar 19.

School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.

Cynatratoside A (CyA) is a C Steroidal glycoside with pregnane skeleton isolated from the root of Bunge (Asclepiadaceae). This study aimed to investigate the effects of CyA on concanavalin A (Con A)-induced autoimmune hepatitis (AIH) and the underlying mechanism. CyA was orally administered to mice at 10 and 40 mg/kg 8 h before and 1 h after Con A treatment. Read More

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http://dx.doi.org/10.3390/molecules24061087DOI Listing
March 2019
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Are High-Dose Steroids Really Necessary in Treatment of Autoimmune Hepatitis?

Clin Gastroenterol Hepatol 2019 Mar 15. Epub 2019 Mar 15.

University of Miami, School of Medicine, Miami, Florida.

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http://dx.doi.org/10.1016/j.cgh.2019.03.018DOI Listing

Dexamethasone Conjugation to Biodegradable Avidin-Nucleic-Acid-Nano-Assemblies Promotes Selective Liver Targeting and Improves Therapeutic Efficacy in an Autoimmune Hepatitis Murine Model.

ACS Nano 2019 Mar 18. Epub 2019 Mar 18.

Department of Pharmaceutical and Pharmacological Sciences , University of Padova , Padova , 35131 , Italy.

Steroids are the standard therapy for autoimmune hepatitis (AIH) but the long-lasting administration is hampered by severe side effects. Methods to improve the tropism of the drug toward the liver are therefore required. Among them, conjugation to nanoparticles represents one possible strategy. Read More

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http://pubs.acs.org/doi/10.1021/acsnano.8b09655
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http://dx.doi.org/10.1021/acsnano.8b09655DOI Listing
March 2019
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Intrahepatic diffuse periportal enhancement patterns on hepatobiliary phase gadoxetate disodium-enhanced liver MR images: Do they correspond to periportal hyperintense patterns on T2-weighted images?

Medicine (Baltimore) 2019 Mar;98(11):e14784

Institute for Clinical Radiology, Ludwig Maximilians-University Hospital Munich, Munich, Germany.

The purpose of this study was to investigate the findings of diffuse periportal enhancement in the liver on hepatobiliary phase gadoxetate disodium-enhanced magnetic resonance images by comparing with the finding of periportal hyperintensity on T2-weighted images and to reveal their clinical significance.Nineteen consecutive patients with diffuse periportal enhancement on hepatobiliary phase images constituted the study population. The intrahepatic diffuse periportal enhancement finding was assessed on whether it corresponded to periportal hyperintense patterns on T2-weighted images or not in the location, and the cases were classified into 2 groups according to this characteristic. Read More

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http://dx.doi.org/10.1097/MD.0000000000014784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426476PMC
March 2019
1 Read

Unusually Low Serum Alkaline Phosphatase Activity in a Patient with Acute on Chronic Liver Failure and Hemolysis.

EJIFCC 2019 Mar 1;30(1):99-105. Epub 2019 Mar 1.

Department of Laboratory Medicine, All India Institute of Medical Sciences, New Delhi, India.

A 28-year-old male with acute on chronic liver failure (ACLF) and hepatic encephalopathy had deranged liver function with curiously low level (0-15 IU/L) of serum alkaline phosphatase (ALP). Peripheral smear examination suggested hemolytic anemia. The finding of persistent low ALP, after ruling out pre-analytical causes, in ACLF has been reported in Wilson's disease (WD) with/ without autoimmune hemolytic anemia (AIHA). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416816PMC
March 2019
5 Reads

Simple Magnetic Resonance Scores Associate With Outcomes of Patients With Primary Sclerosing Cholangitis.

Clin Gastroenterol Hepatol 2019 Mar 14. Epub 2019 Mar 14.

Assistance Publique - Hôpitaux de Paris, Sorbonne University, Department of Radiology, Saint-Antoine Hospital, Paris, France.

Background & Aims: Primary sclerosing cholangitis (PSC) has a variable, often progressive course. Magnetic resonance cholangiography (MRC) is used in diagnosis of PSC. Magnetic resonance risk scoring systems, called Anali without and with gadolinium, are used to predict disease progression, determined by radiologic factors. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.03.013DOI Listing
March 2019
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A Cross Sectional Study of the Impact of Human Immunodeficiency Virus, Hepatitis B Virus and Hepatitis C Virus on Rheumatoid Factor Production.

Arch Rheumatol 2018 Dec 31;33(4):402-407. Epub 2018 Jul 31.

University of Yaounde I, Faculty of Medicine and Biomedical Sciences, Yaounde, Cameroon.

Objectives: This study aims to investigate how human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV) affect the production of immunoglobulin M (IgM)-rheumatoid factor (RF).

Patients And Methods: The study included 405 voluntary participants (139 males, 266 females; mean age 39.4±17. Read More

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http://dx.doi.org/10.5606/ArchRheumatol.2018.6076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409169PMC
December 2018
1 Read

Reply (to LTE HEP-19-0138).

Hepatology 2019 Mar 15. Epub 2019 Mar 15.

Department of Hepatology, Institute of Liver and Biliary Sciences(ILBS), New Delhi, India.

We thank Dr Habib for his interest in our study[1], and emphasizing the difficulties in diagnosing Autoimmune Hepatitis(AIH) in patients presenting with first acute decompensation with no known history of cirrhosis. Our study provides a much-needed criterion for diagnosing such patients. We agree ACLF term often includes a heterogeneous population and includes non-cirrhotics, compensated cirrhotics, previously decompensated cirrhotics, with or without liver failure, and sepsis[2]. Read More

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http://dx.doi.org/10.1002/hep.30614DOI Listing
March 2019
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Letter to Editor: Flare of Autoimmune Hepatitis causing acute on chronic liver failure: diagnosis and response to corticosteroid therapy.

Authors:
Shahid Habib

Hepatology 2019 Mar 15. Epub 2019 Mar 15.

Liver Institute PLLC.

Autoimmune hepatitis (AIH) presents as a chronic necro-inflammatory liver disease in majority of patients, with an acute presentation occurring in up to 25%. AIH criteria were designed to diagnose AIH in patients presenting insidiously. Acute and chronic variants of AIH exhibit variable degree of fibrosis (stage I-IV) despite significant differences in pattern of necroinflammation. Read More

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http://dx.doi.org/10.1002/hep.30615DOI Listing
March 2019
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Letter: severe vitamin D deficiency is a prognostic biomarker in autoimmune hepatitis-offender or bystander? Authors' reply.

Aliment Pharmacol Ther 2019 Apr;49(7):959-960

Division of Gastroenterology & Liver Unit, University of Alberta Hospital, Edmonton, AB, Canada.

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http://dx.doi.org/10.1111/apt.15180DOI Listing
April 2019
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Letter: severe vitamin D deficiency is a prognostic biomarker in autoimmune hepatitis-offender or bystander?

Aliment Pharmacol Ther 2019 Apr;49(7):958

Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and School of Medicine, Tzu Chi University, New Taipei City, Taiwan.

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http://doi.wiley.com/10.1111/apt.15165
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http://dx.doi.org/10.1111/apt.15165DOI Listing
April 2019
4 Reads