10,891 results match your criteria Autoimmune Hepatitis


The Practice Guideline for Vaccinating Korean Patients with Autoimmune Inflammatory Rheumatic Disease.

Infect Chemother 2020 Jun;52(2):252-280

Department of Rheumatology, Chonnam National University Medical School & Hospital, Gwangju, Korea.

To develop a clinical practice guideline for vaccination in patients with autoimmune inflammatory rheumatic disease (AIIRD), the Korean College of Rheumatology and the Korean Society of Infectious Diseases developed a clinical practice guideline according to the clinical practice guideline development manual. Since vaccination is unlikely to cause AIIRD or worsen disease activities, required vaccinations are recommended. Once patients are diagnosed with AIIRD, treatment strategies should be established and, at the same time, monitor their vaccination history. Read More

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http://dx.doi.org/10.3947/ic.2020.52.2.252DOI Listing

Implication of Increased Serum IL-31 for Primary Biliary Cholangitis.

Immunol Invest 2020 Jul 2:1-9. Epub 2020 Jul 2.

Department of Laboratory Medicine, Huangyan Hospital of Wenzhou Medical University, Taizhou First People's Hospital , Taizhou, Zhejiang, China.

Interleukin-31 (IL-31) has diverse biological functions. Increased IL-31 has been found in some skin and autoimmune diseases. There has been no study reporting the association between IL-31 and primary biliary cholangitis (PBC). Read More

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http://dx.doi.org/10.1080/08820139.2020.1785490DOI Listing

Mitomycin, 5-fluorouracil, leflunomide, and mycophenolic acid directly promote hepatitis B virus replication and expression in vitro.

Virol J 2020 Jul 1;17(1):89. Epub 2020 Jul 1.

The Liver Disease Diagnosis and Treatment Center of PLA, Bethune International Peace Hospital, Zhongshanxi street, Shijiazhuang, 050082, Hebei Province, China.

Background: Reactivation of hepatitis B virus is a common complication that occurs in patients with hepatitis B virus (HBV) infection who have received cytotoxic chemotherapy or immunosuppressive therapy. This clinical phenomenon not only occurs in overt HBV infection patients but also occurs in patients with resolved HBV infection. Previous research has confirmed that epirubicin and dexamethasone can stimulate HBV replication and expression directly rather than indirectly through immunosuppression. Read More

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http://dx.doi.org/10.1186/s12985-020-01339-5DOI Listing

A case of non-cirrhotic portal hypertension related to azathioprine therapy in a patient with Crohn's disease.

Intest Res 2020 Jul 2. Epub 2020 Jul 2.

Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.

Azathioprine is widely used for the treatment of Crohn's disease (CD). Few cases from Western countries have reported idiopathic non-cirrhotic portal hypertension (NCPH) related to thiopurine therapy in patients with inflammatory bowel disease. Idiopathic NCPH is a rare hepatic condition with intrahepatic portal hypertension but no evidence of cirrhosis or chronic liver disease. Read More

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http://dx.doi.org/10.5217/ir.2020.00016DOI Listing

Sustained Remission After Treatment Withdrawal in Autoimmune Hepatitis: A Multicenter Retrospective Study.

Dig Dis Sci 2020 Jun 30. Epub 2020 Jun 30.

Department of Hepato-Gastroenterology and Digestive Oncology, Reims University Hospital, 51092, Reims, France.

Background: In patients with autoimmune hepatitis (AIH), relapse rates between 25 and 100% after treatment withdrawal have been reported. The optimal strategy for immunosuppressive treatment withdrawal is controversial.

Aim: To identify the predictive factors of histological remission and to assess the relapse rate after treatment withdrawal in AIH patients with prolonged biochemical response. Read More

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http://dx.doi.org/10.1007/s10620-020-06444-7DOI Listing

Clinical parameters and biomarkers predicting spontaneous operational tolerance after liver transplantation: a scoping review protocol.

F1000Res 2019 5;8:2059. Epub 2019 Dec 5.

Institute of Liver Studies, King's College Hospital, London, London, UK.

This scoping review aims at systematically mapping reported prognostic factors for spontaneous immunosuppression (IS) free allograft tolerance (operational tolerance, OT) in non-viral hepatitis and non-autoimmune disease liver transplant (LT) recipients who are undergoing immunosuppression withdrawal (ISW). The results may inform the subsequent conduct of a systematic review with a more specific review question. LT is currently the most effective treatment for end-stage liver diseases. Read More

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http://dx.doi.org/10.12688/f1000research.21501.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194345.3PMC
December 2019

Safety and Efficacy of Budesonide for Liver Transplant Immune Suppression: Results of a Pilot Phase 2a trial.

Liver Transpl 2020 Jun 30. Epub 2020 Jun 30.

University of Cincinnati, Division of Digestive Diseases, Department of Medicine, Cincinnati, Ohio, USA.

Background And Aims: Despite adverse effects like hyperglycemia, New Onset Diabetes After Transplant (NODAT) and infectious complications; corticosteroids remains an important part of liver transplant (LT) immune suppression. Budesonide, a synthetic corticosteroid, undergoes extensive first-pass hepatic metabolism with only 10% systemic bioavailability, providing an opportunity for improved toxicity-therapeutic ratio. Although effective in the treatment of autoimmune hepatitis, effects of budesonide for LT immune suppression are unknown. Read More

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http://dx.doi.org/10.1002/lt.25837DOI Listing

Autoimmune hepatitis: Possible triggers, potential treatments.

J Hepatol 2020 Jun 26. Epub 2020 Jun 26.

I. Department of Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2020.03.015DOI Listing

[Сlinical, immunological and morphological features in different types of autoimmune hepatitis].

Ter Arkh 2020 Apr 27;92(2):43-47. Epub 2020 Apr 27.

Loginov Moscow Clinical Scientific and Practical Center.

Due to the absence of the pathognomonic diagnostic criteria and to the diversity of clinical, serological and morphological manifestations, the diagnostic of the autoimmune hepatitis (AIH) remains to be a difficult task, which might lead to the delay of the timely beginning of the immunosuppressive therapy (IST), which in turn affects the disease outcomes.

Aim: To studying the clinical, biochemical, immunological and morphological markers in patients with seronegative (SN) and seropositive (SP) AIH and the qualities of their response to the IST.

Materials And Methods: This retrospective cohort study included 82 AIH patients over the course of the years 20142019. Read More

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http://dx.doi.org/10.26442/00403660.2020.02.000536DOI Listing

[Diabetes mellitus and chronic liver diseases. Part 1: general mechanisms of etiology and pathogenesis].

Ter Arkh 2019 Oct 15;91(10):106-111. Epub 2019 Oct 15.

Endocrinology Research Centre.

In recent years there has been an active discussion about the relationship between diabetes mellitus (DM) and chronic liver diseases (CLD). On the one hand, patients with diabetes have an increased risk of developing CLD. On the other hand, patients with CLD very often identify abnormal glucose metabolism which ultimately leads to impaired glucose tolerance and the development of diabetes. Read More

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http://dx.doi.org/10.26442/00403660.2019.10.000165DOI Listing
October 2019

[Diabetes mellitus and chronic liver diseases. Literature review (part 2): treatment features].

Ter Arkh 2019 Dec 15;91(12):115-121. Epub 2019 Dec 15.

Endocrinology Research Centre.

Diabetes mellitus (DM) and chronic liver disease (CLD) are pathological conditions associated with each other and reaching epidemic proportions. There is a strong pathogenetic relationship of carbohydrate metabolism disorders and a number of CLD. Common mechanisms that provoke metabolic and autoimmune disorders in the development of various CLD, leading to steatosis, insulin resistance (IR), impaired glucose tolerance and the development of DM are described. Read More

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http://dx.doi.org/10.26442/00403660.2019.12.000166DOI Listing
December 2019

[Peripheral nervous system lesion in systemic vasculitis - issues of diagnosis and treatment].

Ter Arkh 2019 Dec 15;91(12):63-69. Epub 2019 Dec 15.

Clinic of modern rheumatology.

Vasculitis is a clinically diverse group of diseases with histopathological signs of blood vessel inflammation, which contributes to vascular damage and ischemic damage to the affected tissues. Vasculitic neuropathy is a common complication of the primary systemic vasculitides, such as polyartertis nodosa and antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, systemic diseases of the connective tissue - systemic lupus erythematosus and Sjogren syndrome, vasculitis associated with infection, most often viral hepatitis C and B and non - systemic vasculitis neuropathy. Vessels of medium and small caliber are involved in the pathological process in these diseases. Read More

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http://dx.doi.org/10.26442/00403660.2019.12.000206DOI Listing
December 2019

Disseminated Leishmaniasis Due to Using Immunosuppression Drugs: A Case Report.

Iran J Parasitol 2020 Apr-Jun;15(2):278-281

Pediatric's Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Visceral leishmaniasis is a common parasitic disease between humans and animals, transmitted by sandflies () in the Mediterranean countries, including Iran. The statistics have been reported less than real due to errors in the diagnosis and reporting of affected cases. In this report, we will present the symptoms and manifestations of this disease to reduce late detection and exacerbating factors. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311812PMC

HERBALIFE® ASSOCIATED SEVERE HEPATOTOXICITY IN A PREVIOUSLY HEALTHY WOMAN.

Acta Clin Croat 2019 Dec;58(4):771-776

1Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; 2Department of Gastroenterology and Hepatology, Sveti Duh University Hospital, Zagreb, Croatia; 3Faculty of Health Studies, University of Rijeka, Rijeka, Croatia; 4Department of Endocrinology, Diabetes and Metabolic Diseases, Sveti Duh University Hospital, Zagreb, Croatia; 5Jordanovac Hospital for Lung Diseases, Zagreb University Hospital Centre, Zagreb, Croatia.

Lately there has been an increased consumption of herbal preparations, distributed as nutritional supplements, often claimed to be 'natural' and harmless. However, as their use is not subjected to strict pre-marketing testing and regulations, their ingredients are not clearly defined and there is no quality control or proof of their effectiveness and safety. A growing body of references accentuate their harmful effects, in particular hepatotoxicity, which varies from minimal hepatogram changes to fulminant hepatitis requiring liver transplantation. Read More

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http://dx.doi.org/10.20471/acc.2019.58.04.26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314303PMC
December 2019

Editorial: gut microbiota profile in patients with autoimmune hepatitis-a clue for adjunctive probiotic therapy?

Aliment Pharmacol Ther 2020 Jul;52(2):392-394

Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.1111/apt.15795DOI Listing
July 2020
5.727 Impact Factor

Editorial: gut microbiota profile in patients with autoimmune hepatitis-a clue for adjunctive probiotic therapy? Authors' reply.

Aliment Pharmacol Ther 2020 Jul;52(2):394-395

1st Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1111/apt.15819DOI Listing

Frequent occurrence of low-level positive autoantibodies in chronic hepatitis C.

Pathology 2020 Jun 21. Epub 2020 Jun 21.

School of Biomedical Sciences, University of Western Australia, WA, Australia; Institute for Immunology and Infectious Diseases, Murdoch University, WA, Australia; Department of Clinical Immunology, PathWest, Laboratory Medicine, Queen Elizabeth II Medical Centre, WA, Australia; School of Medicine and Pharmacology, University of Western Australia, WA, Australia.

Evidence of autoimmune disease associated with hepatitis C virus (HCV)-infection has important clinical implications. A systematic profile of these autoantibodies in relevant clinical cohorts relative to healthy controls is needed to better inform current standard of care for chronic hepatitis C. Samples from an Australian cohort of chronic HCV-infected subjects (n=127) were tested for the presence of 19 diagnostic autoantibodies and compared with data available from a control cohort representing a general Caucasian population (n=198). Read More

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http://dx.doi.org/10.1016/j.pathol.2020.05.001DOI Listing

[Coexistence of IgG4-related autoimmune hepatitis and inflammatory pseudotumors of the liver:a case report].

Nihon Shokakibyo Gakkai Zasshi 2020 ;117(6):532-541

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Sapporo Shirakaba-dai Hospital.

IgG4-related autoimmune hepatitis (IgG4-AIH) is characterized by hepatic inflammation and is considered an IgG4-related disease. Several inflammatory pseudotumors (IPTs) are also considered as IgG4-related diseases;however, there have been no reports of cases wherein both diseases occurred concurrently. An older adult with liver dysfunction was admitted to the hospital and was diagnosed with IgG4-AIH following a liver biopsy;IgG4-positive plasma cell infiltration in the portal tract and high serum IgG4 concentration were detected. Read More

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http://dx.doi.org/10.11405/nisshoshi.117.532DOI Listing
January 2020

Multiple Autoimmune Syndrome: An Unusual Combination of Autoimmune Disorders.

Rev Recent Clin Trials 2020 Jun 21. Epub 2020 Jun 21.

Department of Immunology & Molecular biology, Sindh Institute of Urology and Transplantation, Karachi. Pakistan.

Background: Autoimmune diseases are multifactorial with environmental and heritable factors. Autoimmunity reflects an altered immune status therefore presence of more than one disorder is not uncommon. Coexistence of three or more autoimmune diseases in a patient constitutes multiple autoimmune syndrome (MAS). Read More

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http://dx.doi.org/10.2174/1574887115666200621184110DOI Listing

Hyposplenism, Hashimoto's Autoimmune Thyroiditis and Overlap Syndrome (Celiac Disease and Autoimmune Hepatitis Type 1).

Am J Med Sci 2020 Apr 25. Epub 2020 Apr 25.

"Carol Davila" University of Medicine and Pharmacy, "Sf. Ioan" Clinical Emergency Hospital, Gastroenterology Department, Bucharest, Romania.

Hyposplenism is associated with autoimmune diseases, inflammatory bowel disease, severe celiac disease, autoimmune thyroiditis, untreated HIV infection and chronic graft-versus-host disease. The aim of this study was to review the existing data on hyposplenism associated with celiac disease and Hashimoto's autoimmune thyroiditis. Our research was based on a clinical case concerning a 41-year-old female who presented with asthenia, fatigue, dyspepsia and chronic diarrhea. Read More

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http://dx.doi.org/10.1016/j.amjms.2020.04.022DOI Listing

Unusual Distribution of Liver Injury in a Case of Seronegative Autoimmune Hepatitis.

J Pediatr Gastroenterol Nutr 2020 Jul;71(1):e49-e51

Department of Paediatrics, Waikato District Health Board, Hamilton, New Zealand.

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http://dx.doi.org/10.1097/MPG.0000000000002737DOI Listing

APECED-Associated Hepatitis: Clinical, Biochemical, Histological and Treatment Data from a Large Predominantly American Cohort.

Hepatology 2020 Jun 17. Epub 2020 Jun 17.

Translational Hepatology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, Bethesda, Maryland, USA.

Background & Aims: Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED), caused by autoimmune regulator (AIRE) mutations, manifests with chronic mucocutaneous candidiasis (CMC) and multisystem autoimmunity, most often hypoparathyroidism (HP) and adrenal insufficiency (AI). European cohorts previously reported a ~10% prevalence of APECED-associated hepatitis (APAH) with presentations ranging from asymptomatic laboratory derangements to fatal fulminant hepatic failure. Herein, we characterized APAH in a large APECED cohort from the Americas. Read More

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http://dx.doi.org/10.1002/hep.31421DOI Listing

A case report: Long-term complete response of metastatic hepatocellular carcinoma obtained after discontinuation of 2-month sorafenib monotherapy.

Clin J Gastroenterol 2020 Jun 15. Epub 2020 Jun 15.

Division of Gastroenterology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.

A 69-year-old woman who had a history of chronic hepatitis C, autoimmune hemolytic anemia and myelodysplastic syndrome was treated with sorafenib at a daily dose of 400 mg for HCC with multiple lung metastases. Nonetheless, elevated serum tumor markers further increased (alpha fetoprotein from 121,100 to 348,660 ng/ml and protein induced by vitamin K absence/antagonist-II from 3435 to 29,357 mAU/ml), and lung metastatic lesions on chest X-ray showed no improvement after 2 months of sorafenib treatment. Sorafenib was discontinued because of adverse events with diarrhea, fatigue, and severe anemia due to bleeding from stomach telangiectasia. Read More

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http://dx.doi.org/10.1007/s12328-020-01154-zDOI Listing

Infectious complications and timing for liver transplantation in autoimmune acute liver failure in Japan: a subanalysis based on nationwide surveys between 2010 and 2015.

J Gastroenterol 2020 Jun 17. Epub 2020 Jun 17.

Department of Gastroenterology and Hepatology, Faculty of Medicine, Saitama Medical University, Saitama, Japan.

Background: The prognosis of autoimmune acute liver failure (ALF) without liver transplantation (LT) is poor worldwide. We subanalyzed infectious complications of autoimmune ALF using data of nationwide surveys between 2010 and 2015 retrospectively and tried to determine when to evaluate the efficacy of corticosteroid (CS) treatment or abandon it for LT based on objective data.

Methods: One hundred and forty-four patients with autoimmune ALF, comprising 79 ALF with coma ≤ I, 52 ALF with coma ≥ II and 13 late onset hepatic failure (LOHF), were analyzed. Read More

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http://dx.doi.org/10.1007/s00535-020-01699-3DOI Listing

Biologic agents and small-molecule inhibitors in systemic autoimmune conditions: an update.

Pol Arch Intern Med 2020 Jun 18. Epub 2020 Jun 18.

The progress in the understanding of the pathophysiology of rheumatic diseases provided a rational basis for the development of biologic disease-modifying antirheumatic drugs (bDMARDs) and targeted synthetic DMARDs (tsDMARDs) which have completely revolutionized the treatment of inflammatory conditions. These agents differ in their effectiveness for controlling specific rheumatic diseases depending on the pivotal cytokine driving the inflammatory process.  Cytokine blockers were the first to be developed and rapidly expanded. Read More

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http://dx.doi.org/10.20452/pamw.15438DOI Listing

Immune monitoring of a child with autoimmune hepatitis and type 1 diabetes during COVID-19 infection.

Eur J Gastroenterol Hepatol 2020 Jun 16. Epub 2020 Jun 16.

Paediatric Gastroenterology-Hepatology/Liver Transplantation Centre, Koç University.

Immunocompromised patients may be at increased risk to develop COVID-19 during the 2019 β-coronavirus infection. We present the unique opportunity we had to monitor the liver, IL-6 and immune cell course before, during and after COVID-19 in a boy with autoimmune hepatitis (AIH) and type 1 diabetes (T1D). CD4 and CD8 T cells frequencies decreased because of prednisolone, followed by a plateauing increase whereas CD19CD20 B cell increased strongly and was unaffected by COVID-19 infection. Read More

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http://dx.doi.org/10.1097/MEG.0000000000001804DOI Listing

[Autoimmune Hepatitis in Small Cell Lung Cancer-A Case Report].

Gan To Kagaku Ryoho 2020 Jun;47(6):963-965

Dept. of Respiratory, Yokosuka Kyosai Hospital.

A 64-year-old female presented to our hospital with a chronic cough. She was diagnosed with cStage ⅢA small cell lung cancer(cT2aN2M0, limited disease). On admission for chemoradiation therapy, laboratory data incidentally revealed liver dysfunction. Read More

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Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms.

J Vis Exp 2020 May 29(159). Epub 2020 May 29.

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University; Department of Pediatrics and Pathology, Johns Hopkins University;

Drug-induced autoimmune hepatitis (DIH) is the most common hepatic drug-induced hypersensitization process observed in approximately 9 to 12% of patients with autoimmune hepatitis. The overwhelming majority of patients with DIH are women. The underlying mechanisms of these sex differences in prevalence are unclear because of the paucity of animal models that mimic human disease. Read More

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http://dx.doi.org/10.3791/59174DOI Listing

Anti-rod and ring antibodies in patients with chronic hepatitis C using direct-acting antivirals.

Immunol Res 2020 Jun 14. Epub 2020 Jun 14.

Department of Internal Medicine, Center of Medical Sciences, UFPE, Av. Professor Moraes Rego, 1235, Recife, PE, 50670-901, Brazil.

Anti-rods and rings (anti-RR) antibody induction is related to the combination of interferon and ribavirin in the treatment of hepatitis C virus (HCV) infection. If the main factor leading to this autoimmune reaction is the combination of these drugs, is not well known, but in vitro studies shows that ribavirin alone can induce rods and rings structures. New direct-acting antivirals (DAAs) permit HCV treatment without needing interferon but may be associated with ribavirin in the most difficult-to-treat patients. Read More

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http://dx.doi.org/10.1007/s12026-020-09136-6DOI Listing

Diverse Virus and Host-Dependent Mechanisms Influence the Systemic and Intrahepatic Immune Responses in the Woodchuck Model of Hepatitis B.

Front Immunol 2020 27;11:853. Epub 2020 May 27.

Molecular Virology and Hepatology Research Group, Division of BioMedical Sciences, Faculty of Medicine, Health Sciences Centre, Memorial University of Newfoundland, St. John's, NL, Canada.

Woodchuck infected with woodchuck hepatitis virus (WHV) represents the pathogenically nearest model of hepatitis B and associated hepatocellular carcinoma (HCC). This naturally occurring animal model also is highly valuable for development and preclinical evaluation of new anti-HBV agents and immunotherapies against chronic hepatitis (CH) B and HCC. Studies in this system uncovered a number of molecular and immunological processes which contribute or likely contribute to the immunopathogenesis of liver disease and modulation of the systemic and intrahepatic innate and adaptive immune responses during hepadnaviral infection. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267019PMC

Preoperative Neutrophil-to-Lymphocyte Ratio as an Independent Predictor of 1-Year Graft Loss and Mortality After Orthotopic Liver Transplantation.

Transplant Proc 2020 Jun 11. Epub 2020 Jun 11.

Department of General, Vascular and Transplant Surgery, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland. Electronic address:

Introduction: Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are low-cost and readily available inflammation markers. Previously, we revealed that the high preoperative neutrophil level is a recipient-related risk factor for the primary liver graft dysfunction (PGD), associated with a higher risk of early retransplantation or death. Here we aimed to evaluate the prognostic significance of preoperative neutrophil level, as well as the NLR and PLR in predicting a 1-year outcome of the orthotopic liver transplantation (OLTx). Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.03.036DOI Listing

Nonalcoholic Steatohepatitis is the Most Rapidly Increasing Indication for Liver Transplantation in the United States.

Clin Gastroenterol Hepatol 2020 Jun 9. Epub 2020 Jun 9.

Center for Outcomes Research in Liver Diseases, Washington, DC.

Background & Aims: The profile of chronic liver disease (CLD) in the United States has changed due to obesity trends and advances in treatment of viral hepatitis. We assessed liver transplant listing trends by CLD etiology.

Methods: Adult candidates for liver transplantation were selected from the Scientific Registry of Transplant Recipients (2002 through 2019). Read More

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http://dx.doi.org/10.1016/j.cgh.2020.05.064DOI Listing
June 2020
7.896 Impact Factor

Trends in Incidence of Autoimmune Liver Diseases and Increasing Incidence of Autoimmune Hepatitis.

Clin Gastroenterol Hepatol 2020 Jun 8. Epub 2020 Jun 8.

Department of Gastroenterology, Christchurch Hospital, Christchurch, New Zealand; University of Otago, Christchurch, New Zealand. Electronic address:

Background & Aims: Autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC) are autoimmune liver diseases of unknown etiology. We studied trends in incidences of AIH, PBC, and PSC in a population-based prospective study Canterbury, New Zealand.

Methods: We collected data on patients with AIH (n=99), PBC (n=26), or PSC (n=47) from public hospitals and private practices in Canterbury from 2008 through 2016. Read More

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http://dx.doi.org/10.1016/j.cgh.2020.05.061DOI Listing

High rates of 30-day mortality in patients with cirrhosis and COVID-19.

J Hepatol 2020 Jun 8. Epub 2020 Jun 8.

Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Division of Gastroenterology and Hepatology, CRC "A. M. and A. Migliavacca" Center for Liver Disease, Milan, Italy; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.

Background And Aims: Coronavirus disease (COVID-19) is a major worldwide threat for healthy individuals as well as for patients with comorbidities, but its impact on patients with cirrhosis is currently unknown. This study aimed at evaluating the impact of COVID-19 on the clinical outcome of these patients.

Methods: In this multicenter retrospective study, cirrhotic patients with confirmed Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection were enrolled between 1 and 31 March 2020. Read More

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http://dx.doi.org/10.1016/j.jhep.2020.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280108PMC

Role of γδT cells in liver diseases and its relationship with intestinal microbiota.

World J Gastroenterol 2020 May;26(20):2559-2569

Department of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310000, Zhejiang Province, China.

γδT cells are unconventional T lymphocytes that bridge innate and adaptive immunity. Based on the composition of T cell receptor and the cytokines produced, γδT cells can be divided into diverse subsets that may be present at different locations, including the liver, epithelial layer of the gut, the dermis and so on. Many of these cells perform specific functions in liver diseases, such as viral hepatitis, autoimmune liver diseases, non-alcoholic fatty liver disease, liver cirrhosis and liver cancers. Read More

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http://dx.doi.org/10.3748/wjg.v26.i20.2559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265152PMC

Methotrexate-associated Lymphoproliferative Disorder in the Liver Resembling Hepatocellular Carcinoma Treated with Transarterial Chemoembolization.

Intern Med 2020 Jun 9. Epub 2020 Jun 9.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Japan.

Methotrexate-related lymphoproliferative disorder (MTX-LPD) is known to be a side effect of MTX, but its involvement in the liver has been rarely reported. We herein report a 70-year-old woman with autoimmune hepatitis and rheumatoid arthritis who developed multiple liver tumors. We initially considered that she had developed rapid-growing HCC in the cirrhotic liver based on imaging tests. Read More

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http://dx.doi.org/10.2169/internalmedicine.4787-20DOI Listing

Cryoglobulinemia after the era of chronic hepatitis C infection.

Semin Arthritis Rheum 2020 May 26;50(4):695-700. Epub 2020 May 26.

Sorbonne Université, UPMC Univ Paris 06, UMR 7211, Inflammation-Immunopathology-Biotherapy Department (DHU i2B), F-75005, Paris, France; INSERM, UMR_S 959, F-75013, Paris, France, CNRS, FRE3632, F-75005, Paris, France; AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, F-75013, Paris, France; Centre de Référence des Maladies Auto-Immunes et Systémiques Rares, Centre de Référence des Maladies Auto-Inflammatoires et de l'Amylose, France. Electronic address:

Objectives: Historically chronic hepatitis C virus (HCV) infection accounted for the majority of mixed cryoglobulinemia (MC). The advent of direct-acting antivirals (DAA) against HCV has dramatically changed the management and the prevalence of chronic HCV infection. We aimed to describe the spectrum of MC in the era of DAA agents. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2020.05.004DOI Listing

"Autoimmune Hepatitis in Children: Prednisone Plus Azathioprine vs Cyclosporine: A Randomized Trial".

J Pediatr Gastroenterol Nutr 2020 Jun 9. Epub 2020 Jun 9.

Department of Pediatrics, CHU-Sainte Justine, University of Montreal, Canada.

Objective: To study the outcome and adverse effects of two initial treatments in children with autoimmune hepatitis (AIH), prednisone (PRED) plus azathioprine (AZA) vs cyclosporine (CsA).

Study Design: Between 12/2008-2/2012, 50 consecutive patients were centrally randomized to one of two treatment arms. Group 1: PRED was indicated at a dose of 1-2 mg/kg/day (up to 60 mg/day) and AZA at a dose of 1-2 mg/kg/day. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002776DOI Listing

Safety of Thiopurine Use in Paediatric Gastrointestinal Disease.

J Pediatr Gastroenterol Nutr 2020 Jun 9. Epub 2020 Jun 9.

Neurogastroenterology and Motility Unit, UCL Great Ormond Street Institute for Child Health and Great Ormond Street Hospital, London, United Kingdom.

Thiopurines, alone or in combination with other agents, have a pivotal role in the treatment of specific gastrointestinal and hepatological disorders. In inflammatory bowel disease and autoimmune hepatitis thiopurines have proven their value as steroid sparing agents for the maintenance of remission and may be considered for preventing postoperative Crohn's disease recurrence where there is moderate risk of this occuring. Their use with infliximab therapy reduces antibody formation and increases biologic drug levels. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002802DOI Listing

Extract of Ascaris suum induces TGF-β and early production of IgG1 in experimental autoimmune hepatitis.

Rev Bras Parasitol Vet 2020 8;29(2):e023419. Epub 2020 Jun 8.

Laboratório de Imunopatologia Keizo Asami, Universidade Federal de Pernambuco - UFPE, Recife, PE, Brasil.

In experimental autoimmune hepatitis (EAH) of Th1 profile, an extract of adult Ascaris suum worms (ASC) was previously found to deviate the immune response to a Th2/IL-10 pattern. Here, the effects of treatment with ASC on production of TGF-β and the anti-Ascaris isotypes IgG1 and IgG2a in EAH were evaluated. EAH was induced in BALB/c mice, intravenously with concanavalin A. Read More

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http://dx.doi.org/10.1590/S1984-29612020031DOI Listing

Histopathological analysis of autoimmune hepatitis with "acute" presentation - differentiation from drug-induced liver injury.

Hepatol Res 2020 Jun 9. Epub 2020 Jun 9.

Department of Hepatology, Kagawa Prefectural Central Hospital, Kagawa.

Background And Aims: Presently, no standardized definition or acceptable diagnostic criteria have been established for acute presentation of autoimmune hepatitis (AP-AIH), making it difficult to differentiate that condition from drug-induced liver injury (DILI). This study aimed to characterize clinical and histological features for distinguishing between AP-AIH and DILI.

Methods: Clinical, biochemical, and histological characteristics of AP-AIH and DILI in clinically well-characterized cases were compared in a standardized manner to clarify differences. Read More

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http://dx.doi.org/10.1111/hepr.13532DOI Listing

Efficacy and safety of chloroquine plus prednisone for the treatment of autoimmune hepatitis in a randomized trial.

JGH Open 2020 Jun 10;4(3):371-377. Epub 2019 Sep 10.

Division of Gastroenterology and Hepatology Hospital das Clinicas, University of São Paulo School of Medicine São Paulo Brazil.

Background And Aim: Standard treatment for autoimmune hepatitis (AIH) consists of predniso(lo)ne and azathioprine. However, alternative therapy is required for non- or partial responders and in cases of side effects. The aim of this study was to evaluate the treatment outcomes associated with chloroquine plus prednisone in AIH patients. Read More

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http://dx.doi.org/10.1002/jgh3.12258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273702PMC

Risk of hepatocellular carcinoma in Danish outpatients with alcohol-related cirrhosis.

J Hepatol 2020 Jun 5. Epub 2020 Jun 5.

Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.

Background And Aims: Accurate estimates of the risk of hepatocellular carcinoma (HCC) in patients with cirrhosis are important for clinical decisions about HCC surveillance. We described HCC risk among outpatients with alcoholic cirrhosis and contrasted the risk of death from HCC with the risk of death from variceal bleeding or trauma.

Methods: This was a nationwide, registry-based historical cohort study between 2006 and 2018. Read More

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http://dx.doi.org/10.1016/j.jhep.2020.05.043DOI Listing

Liver injury caused by oral anticoagulants: A population-based retrospective cohort study.

Liver Int 2020 Jun 8. Epub 2020 Jun 8.

Department of Internal Medicine, Section of Gastroenterology and Hepatology, Landspitali University Hospital, Reykjavik, Iceland.

Background & Aims: Idiosyncratic drug-induced liver injury (DILI) is a rare adverse event. DILI caused by direct oral anticoagulants (DOACs) has been reported, however, data on the risk of DILI are limited. The aim of the study was to evaluate the frequency of DILI caused by oral anticoagulants (OACs) in a population-based setting. Read More

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http://dx.doi.org/10.1111/liv.14559DOI Listing

Liver fibrosis with two-dimensional shear-wave elastography in patients with autoimmune hepatitis.

Expert Rev Gastroenterol Hepatol 2020 Jun 18:1-8. Epub 2020 Jun 18.

Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University , Chengdu, Sichuan, People's Republic of China.

Background: Two-dimensional shear-wave elastography (2D-SWE) is an ultrasound-based real-time 2D-SWE imaging technique for noninvasive assessment of liver fibrosis. The diagnostic performance of 2D-SWE for assessing liver fibrosis in patients with autoimmune hepatitis (AIH) has not been reported.

Aims: To evaluate the diagnostic performance of 2D-SWE and serologic tests including the aspartate amino transferase-to-platelet ratio index (APRI) and fibrosis-4 index (FIB-4) for liver fibrosis staging in patients with AIH. Read More

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http://dx.doi.org/10.1080/17474124.2020.1779589DOI Listing
June 2020
2.546 Impact Factor

Prevalence of torque teno virus in healthy individuals and those infected with hepatitis C virus living in Yazd, Iran.

Caspian J Intern Med 2020 ;11(2):199-204

Gastroentrology Department, Shahid Sadoughi Hospital, Faculty of Medicine,, Shahid Sadoughi University of Medical Sciences,Yazd, Iran.

Background: Torque teno virus (TTV) is a non-enveloped DNA virus that its role as a helper or causative agent in hepatitis is still unclear. TTV prevalence varies in different regions of the world. This study aimed to determine the prevalence of TTV in healthy individuals and those infected with hepatitis C virus (HCV) living in Yazd city, Iran. Read More

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http://dx.doi.org/10.22088/cjim.11.2.199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265513PMC
January 2020

Severe Acute Hepatitis E in a Woman with an Autoimmune Background.

Acta Med Port 2020 Jun 31;33(6):425-428. Epub 2020 May 31.

Epidemiology Research Unit. Instituto de Saúde Pública. Universidade do Porto. Porto. Instituto de Ciências Biomédicas de Abel Salazar. Universidade do Porto. Porto. Portugal.

Hepatitis E virus genotype 3 infections are normally asymptomatic in immunocompetent individuals. Symptomatic cases of acute icteric hepatitis E are seldom observed among women, younger men and children but are particularly seen in middle-aged/elderly men. We report a case of severe acute hepatitis E caused by genotype 3 in an immunocompetent 40-year-old woman that required prolonged hospitalization. Read More

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http://dx.doi.org/10.20344/amp.10429DOI Listing

Immunosuppressive Treatment Regimens in Autoimmune Hepatitis: Systematic Reviews and Meta-Analyses Supporting AASLD Guidelines.

Hepatology 2020 Jun 4. Epub 2020 Jun 4.

Mayo Clinic Evidence-Based Practice Research Program, USA.

Three key management decisions in autoimmune hepatitis concern the use of budesonide and azathioprine as first-line therapy, the choice of mycophenolate mofetil or calcineurin inhibitors for patients failing steroids and azathioprine, and the role of maintenance steroids in prevention of recurrence after liver transplantation. To address these questions, comprehensive searches were performed (without language restrictions) of several databases from their inceptions to January 8, 2019. From 1,712 citations identified, the full texts of 578 studies were reviewed, and 13 studies met criteria for systematic review. Read More

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http://dx.doi.org/10.1002/hep.31407DOI Listing

The Relationship between Annual Airborne Pollen Levels and Occurrence of All Cancers, and Lung, Stomach, Colorectal, Pancreatic and Breast Cancers: A Retrospective Study from the National Registry Database of Cancer Incidence in Japan, 1975-2015.

Int J Environ Res Public Health 2020 Jun 2;17(11). Epub 2020 Jun 2.

Department of Neurology and Stroke Center, University Hospital Mizonokuchi, Teikyo University School of Medicine, 5-1-1, Futago, Takatsu-ku, Kawasaki, Kanagawa 213-8507, Japan.

Suppression of risk factors including smoking, overdrinking and infections by human papilloma and hepatitis B and C viruses has been recommended for cancer prevention; however, identification of other environmental risk factors has not been enough. Besides the 2003 report that Kawasaki disease may be triggered by pollen exposure, 40 Japanese specific intractable diseases have recently been reported as "pollen diseases," also potentially triggered by pollen exposure.Various human organs are affected by pollen exposure, leading to systemic vasculitis; autoimmune connective tissue diseases, inflammatory bowel diseases and intractable neuromuscular and bone diseases, suggesting the common effects of pollen exposure on fundamental functions of vital metabolism. In this context, cancer and malignant tumors may be another group of intractable diseases triggered by epigenetic pollen exposure. Read More

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http://dx.doi.org/10.3390/ijerph17113950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312994PMC