11,497 results match your criteria Autoimmune Hepatitis

Use of thiopurines is not a risk factor for post-ERC pancreatitis in patients with primary sclerosing cholangitis.

Dig Liver Dis 2021 Jun 8. Epub 2021 Jun 8.

Department of Gastroenterology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Introduction: Risk of post-ERC pancreatitis (PEP) in patients with primary sclerosing cholangitis (PSC) is 1-7.8%. PSC is often associated with inflammatory bowel disease and autoimmune hepatitis, which are usually treated with thiopurines. Read More

View Article and Full-Text PDF

Coexistence of immune-mediated diseases in sarcoidosis Frequency and clinical significance in 1737 patients.

Joint Bone Spine 2021 Jun 8:105236. Epub 2021 Jun 8.

Department of Medicine, Universitat de Barcelona, Barcelona, Spain; Department of Autoimmune Diseases, ICMiD, Hospital Clinic, Barcelona, Spain. Electronic address:

Objective: To analyze whether immune-mediated diseases (IMDs) occurs in sarcoidosis more commonly than expected in the general population, and how concomitant IMDs influence the clinical presentation of the disease.

Methods: We searched for coexisting IMDs in patients included in the SARCOGEAS-cohort, a multicenter nationwide database of consecutive patients diagnosed according to the ATS/ESC/WASOG criteria. Comparisons were made considering the presence or absence of IMD clustering, and odds ratios (OR) and their 95% confidence intervals (CI) were calculated as the ratio of observed cases of every IMD in the sarcoidosis cohort to the observed cases in the general population. Read More

View Article and Full-Text PDF

Autoimmune hepatitis following sars-cov-2 VACCINE: MAY not be a casualty.

J Hepatol 2021 Jun 8. Epub 2021 Jun 8.

Department of Clinical Medicine and Surgery, Gastroenterology and Hepatology, University Federico II of Naples.

View Article and Full-Text PDF

Identification of an Autoantibody Against ErbB-3-Binding Protein-1 in the Sera of Patients With Chronic Hepatitis B Virus Infection.

Front Immunol 2021 25;12:640335. Epub 2021 May 25.

Department of Immunology & Institute of Immunology, Army Medical University (Third Military Medical University), Chongqing, China.

Background: Studies have shown that autoimmune response contributes to chronic hepatitis B (CHB) development.

Aim: This study aimed to identify autoantibodies in the sera of patients with CHB and to investigate the association of autoimmune response with disease severity in CHB.

Methods: Proteins from human liver carcinoma cell line HepG2 were separated by two-dimensional electrophoresis. Read More

View Article and Full-Text PDF

Inhibition of miR-431-5p attenuated liver apoptosis through KLF15/p53 signal pathway in S100 induced autoimmune hepatitis mice.

Life Sci 2021 Jun 7;280:119698. Epub 2021 Jun 7.

Department of Infectious Diseases, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang Provincial Key Laboratory for Accurate Diagnosis and Treatment of Chronic Liver Diseases, Wenzhou Key Laboratory of Hepatology, Hepatology Institute of Wenzhou Medical University, Wenzhou 325006, China. Electronic address:

Aims: The purpose of this study was to investigate the effects of miR-431-5p on hepatocyte apoptosis in AIH.

Materials And Methods: We used intraperitoneal injection of S100 to establish AIH mouse model and injected AAV into tail vein on day 14 of modeling to regulate miR-431-5p expression. The expression of ALT, AST, IgG and apoptosis-related proteins Bax, Bcl-2 and cleaved caspase 3 were measured in each group. Read More

View Article and Full-Text PDF

Superior outcome for splenectomised patients in a population-based study of splenic marginal zone lymphoma in Sweden.

Br J Haematol 2021 Jun 9. Epub 2021 Jun 9.

Clinical and Experimental Pathology, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala University Hospital, Uppsala, Sweden.

Splenic marginal zone lymphoma (SMZL) is a rare low-grade B-cell lymphoma where associations with viral hepatitis and autoimmune and inflammatory diseases (AID) have been indicated. We aimed at assessing the prevalence of viral hepatitis and AID at SMZL diagnosis and outcome by treatment in a Swedish population-based study. A total of 277 SMZL patients registered in the Swedish Lymphoma Register in 2007-2017 were included. Read More

View Article and Full-Text PDF

Response to E. Shahini and F. Ahmed Letter JHEPAT-D-21-00372.

J Hepatol 2021 Jun 6. Epub 2021 Jun 6.

Reference center for inflammatory biliary diseases and autoimmune hepatitis (MIVB-H), French reference network for rare liver diseases in children and adults (FILFOIE), European reference network for rare hepatological diseases (RARE-LIVER), Saint-Antoine Hospital, Assistance Publique - Hôpitaux de Paris (APHP); Inserm UMR_S938, Saint-Antoine Research Center (CRSA), Sorbonne University; 184 rue du faubourg Saint-Antoine, 75571 Paris, Cedex 12, France. Electronic address:

View Article and Full-Text PDF

Clinical spectrum of chronic liver disease with final outcome in children at a tertiary centre: A single - centre study.

Pak J Med Sci 2021 May-Jun;37(3):680-683

Dr. Usman Iqbal Aujla, Consultant Gastroenterologist , Pakistan Kidney and Liver Institute & Research Centre, Lahore, Pakistan.

Background And Objectives: Chronic liver disease (CLD) in children present a broad spectrum of symptoms. Limited resources in Paediatric Hepatology in developing countries like Pakistan present considerable challenges in investigating and treating children with chronic liver disease in a timely fashion. This study aimed to determine the spectrum and outcomes of CLD other than chronic hep B & C virus (HBV& HCV) liver disease in children. Read More

View Article and Full-Text PDF

Early Dynamics of MELD Scores Predict Corticosteroid Responsiveness to Severe Acute-onset Autoimmune Hepatitis.

Clin Gastroenterol Hepatol 2021 Jun 5. Epub 2021 Jun 5.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. Electronic address:

View Article and Full-Text PDF

Creatinine-lactate score predicts mortality in non-acetaminophen-induced acute liver failure in patients listed for liver transplantation.

BMC Gastroenterol 2021 Jun 7;21(1):252. Epub 2021 Jun 7.

Laboratorio de Investigaçao Medica 37, Departamento de Gastroenterologia, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo - HCFMUSP, Sao Paulo, SP, Brazil.

Background: The aim of this study was to analyze prognostic indicators of in-hospital mortality among patients listed for urgent liver transplantation (LT) for non-acetaminophen (APAP)-induced acute liver failure (ALF).

Methods: ALF patients listed for LT according to the King's College Criteria were retrospectively reviewed. Variables were recorded from medical records and electronic databases (HCMED and RedCap). Read More

View Article and Full-Text PDF

Oral Microbiome Characteristics in Patients With Autoimmune Hepatitis.

Front Cell Infect Microbiol 2021 19;11:656674. Epub 2021 May 19.

Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Autoimmune hepatitis (AIH) is a common cause of liver cirrhosis. To identify the characteristics of the oral microbiome in patients with AIH, we collected 204 saliva samples including 68 AIH patients and 136 healthy controls and performed microbial MiSeq sequencing after screening. All samples were randomly divided into discovery cohorts (46 AIH and 92 HCs) and validation cohorts (22 AIH and 44 HCs). Read More

View Article and Full-Text PDF


Wiad Lek 2021 ;74(5):1180-1188


Objective: The aim: To establish the dependence of the concentration of galectin-9(CGal-9) in the serum of patients with chronic viral hepatitis C (CVHC) on the type of antiviral therapy (AVT), clinical-laboratory, autoimmune and integrative parameters, non-invasive methods of assessing the degree of fibrosis.

Patients And Methods: Materials and methods: CGal-9 in serum were determined in 68 patients with CVHC and 20 healthy individuals, and clinical-laboratory and integrative parameters, noninvasive methods for assessing the degree of fibrosis were studied.

Results: Results:There were three groups: baseline (I), pegylated interferon (PEG-IFN) with ribavirin (II), velpatasvir with sofosbuvir (III). Read More

View Article and Full-Text PDF

Blind liver biopsy: a 17-year experience.

Rev Gastroenterol Peru 2020 Oct-Dec;40(4):322-328

SBU Sisli Etfal Training and Research Hospital, Department of Pathology. Istanbul, Turkey.

Objectives: Liver biopsy is the gold standard for assessing liver inflammation, necrosis and fibrosis. The aim of the study is to evaluate clinical indications and histopathological results of percutaneus liver biopsy.

Materials And Methods: A total of 516 children who underwent blind liver biopsy were evaluated retrospectively. Read More

View Article and Full-Text PDF

Serum Sickness-Like Reaction Associated With Acute Hepatitis B in a Previously Vaccinated Adult Male.

Cureus 2021 Apr 28;13(4):e14742. Epub 2021 Apr 28.

Infectious Disease, Michigan State University/Hurley Medical Center, Flint, USA.

Serum sickness is a well-known immune complex deposition phenomenon, occurring as a reaction to proteins in antiserum from a non-human animal source. Serum sickness-like reaction (SSLR), typically associated with drugs and vaccines, sometimes occurs with acute hepatitis B infection and poses a diagnostic dilemma for clinicians, as other viral syndromes, vasculitic processes, and autoimmune conditions can have similar presentations. We present a 36-year-old intravenous drug user, with confirmed records of hepatitis B immunization, who presented with multi-joint pain, joint swelling, and a skin rash. Read More

View Article and Full-Text PDF

Characteristics of patients with coexisting DNAJB9-associated fibrillary glomerulonephritis and IgA nephropathy.

Clin Kidney J 2021 Jun 5;14(6):1681-1690. Epub 2020 Dec 5.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

Background: Coexistence of fibrillary glomerulonephritis (FGN) and immunoglobulin A (IgA) nephropathy (IgAN) in the same kidney biopsy (FGN-IgAN) is rare, and the clinicopathologic characteristics and outcome of this dual glomerulopathy are unknown.

Methods: In this study, 20 patients with FGN-IgAN were studied and their characteristics were compared with 40 FGN and 40 IgAN control patients.

Results: Concurrent IgAN was present in 1. Read More

View Article and Full-Text PDF

Acute Liver Failure Etiology is an Independent Predictor of Waitlist Outcome, but not Post-Transplant Survival in a National Cohort.

Liver Transpl 2021 Jun 3. Epub 2021 Jun 3.

Division of Gastroenterology / Transplant Hepatology, University of Pennsylvania, Philadelphia.

The impact of acute liver failure (ALF) etiology on waitlist and post-transplant outcomes, independent of severity of illness is incompletely characterized. All adults (N=1,691) listed for primary liver transplantation (LT) between 2002-2019 with ALF due to acetaminophen (APAP), drug-induced liver injury (DILI), autoimmune hepatitis (AIH) and hepatitis B virus (HBV) were identified in the United Network for Organ Sharing database. ALF etiology was evaluated as an independent predictor of waitlist mortality and spontaneous survivorship (SS; versus outcome of LT), as well as post-LT overall survival, graft survival and in-hospital mortality using multivariable models that accounting for differences in clinical parameters at listing. Read More

View Article and Full-Text PDF

Case Report: Viral Pneumonia Could Prompt the Advancement of Immune-Mediated Liver Disease.

Front Med (Lausanne) 2021 17;8:582620. Epub 2021 May 17.

Department of Hepatology, The Fifth People's Hospital of Wuxi, Jiangnan University, Wuxi, China.

The impact of the influenza A (H1N1) and SARS-CoV-2 virus on the development of autoimmune hepatitis has not been described previously. In this case series, we evaluated the dynamic changes in liver function of three patients with autoimmune hepatitis who presented with viral infection (two with the H1N1 and one with the SARS-CoV-2 virus) during the recent COVID-19 outbreak. Patient 1 was a 68-year-old woman with a history of hepatitis of unknown origin before being infected with the H1N1 virus. Read More

View Article and Full-Text PDF

Meta-Analysis and Systematic Review of Primary Renal Tubular Acidosis in Patients With Autoimmune Hepatitis and Alcoholic Hepatitis.

Cureus 2021 May 28;13(5):e15287. Epub 2021 May 28.

Gastroenterology and Hepatology, University Hospitals of Morecambe Bay NHS Foundation Trust, Lancaster, GBR.

Renal and hepatic functions are often mingled through both the existence of associated primary organ diseases and hemodynamic co-relationship. The primary objective of this study was to sum up the relationship between autoimmune hepatitis (AIH) on renal tubular acidosis (RTA) and the stages of the disease. A systematic review was performed for 24 trials. Read More

View Article and Full-Text PDF

Chronic recurrent multifocal osteomyelitis and primary sclerosing cholangitis with type 1 autoimmune hepatitis in a child with ulcerative colitis: a case report.

BMC Rheumatol 2021 Jun 3;5(1):16. Epub 2021 Jun 3.

Division of Rheumatology, Department of Pediatrics, University of British Columbia, Vancouver, Canada.

Background: Chronic Recurrent Multifocal Osteomyelitis (CRMO) is a condition characterized by sterile bone inflammation, usually occurring in childhood. Although the etiology remains unclear, this condition has been associated with inflammatory bowel disease (IBD). Primary sclerosing cholangitis (PSC) and Autoimmune Hepatitis (AIH) are also uncommon pediatric conditions with a known association with IBD. Read More

View Article and Full-Text PDF

Rare genetic mutation triggering acute liver failure in a toddler requiring a liver transplant.

Pediatr Transplant 2021 Jun 2:e14048. Epub 2021 Jun 2.

Department of Pediatric Gastroenterology, Hepatology, and Nutrition, Cleveland Clinic, Cleveland, OH, USA.

APS-1 is an extremely rare, autosomal recessive condition that often presents with candidiasis, adrenal insufficiency, and hypoparathyroidism. This condition is associated with autoimmune hepatitis in less than 20% of cases, and there have only been a few reports of children with the condition who developed ALF. We present a unique case of an infant with APS-1 who developed ALF and subsequently required liver transplantation. Read More

View Article and Full-Text PDF

The characteristics of pediatric ulcerative colitis with primary sclerosing cholangitis: A single-center study in Taiwan.

Pediatr Neonatol 2021 May 11. Epub 2021 May 11.

Department of Pediatrics, National Taiwan University Children's Hospital, National Taiwan University, Taipei, Taiwan. Electronic address:

Background: Primary sclerosing cholangitis (PSC) is often associated with ulcerative colitis (UC). We investigated the clinical characteristics of pediatric UC patients with and without PSC.

Methods: We retrospectively recruited children with UC, with and without PSC, from 2006 to 2017 in a tertiary center in Taiwan. Read More

View Article and Full-Text PDF

Invasive listeriosis in a patient with autoimmune hepatitis on glucocorticosteroid therapy.

Med Clin (Barc) 2021 May 29. Epub 2021 May 29.

Servicio de Aparato Digestivo, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Universidad Autónoma de Madrid (UAM), Madrid, España.

View Article and Full-Text PDF

Synthesis of Multifunctional Nanoparticles for the Combination of Photodynamic Therapy and Immunotherapy.

Pharmaceuticals (Basel) 2021 May 26;14(6). Epub 2021 May 26.

Department of Chemical and Materials Engineering, National University of Kaohsiung, Kaohsiung 81148, Taiwan.

Programmed death-ligand 1 protein (PD-L1) has been posited to have a major role in suppressing the immune system during pregnancy, tissue allografts, autoimmune disease and other diseases, such as hepatitis. Photodynamic therapy uses light and a photosensitizer to generate singlet oxygen, which causes cell death (phototoxicity). In this work, photosensitizers (such as merocyanine) were immobilized on the surface of magnetic nanoparticles. Read More

View Article and Full-Text PDF

Diffuse gallbladder wall thickening in autoimmune hepatitis: an unusual presentation.

BMJ Case Rep 2021 May 31;14(5). Epub 2021 May 31.

Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

A 63-year-old woman presented with jaundice and epigastric pain for 2 weeks. Physical examination revealed marked jaundice, and palpable gallbladder with right upper quadrant tenderness. Liver function test was remarkable for hepatocellular injury pattern. Read More

View Article and Full-Text PDF

Paediatric autoimmune liver diseases: A descriptive study of patients from Saudi Arabia.

Arab J Gastroenterol 2021 May 28. Epub 2021 May 28.

Paediatric Gastroenterology Unit, Department of Paediatrics, King Abdulaziz University Hospital, Jeddah, Saudi Arabia.

Background And Study Aims: Autoimmune liver diseases (ALDs) are a clinico-pathologic spectrum of disorders that share some similarities. They are formally classified as autoimmune hepatitis (AIH), isolated autoimmune sclerosing cholangitis (ASC), and the overlap syndrome of these. We describe the clinical, biochemical, and outcomes data of a cohort of autoimmune ALDs patients in a tertiary care centre. Read More

View Article and Full-Text PDF

A large-scale investigation into the role of classical HLA loci in multiple types of severe infections, with a focus on overlaps with autoimmune and mental disorders.

J Transl Med 2021 May 31;19(1):230. Epub 2021 May 31.

iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.

Background: Infections are a major disease burden worldwide. While they are caused by external pathogens, host genetics also plays a part in susceptibility to infections. Past studies have reported diverse associations between human leukocyte antigen (HLA) alleles and infections, but many were limited by small sample sizes and/or focused on only one infection. Read More

View Article and Full-Text PDF

Corrigendum to "Erythropoietin administration expands regulatory T cells in patients with autoimmune hepatitis" [J. Autoimmun. 119C (2021) 102629].

J Autoimmun 2021 Jul 28;121:102665. Epub 2021 May 28.

Department of Internal Medicine, Northwestern University, Chicago, IL, USA; Northwestern Feinberg School of Medicine, Chicago, IL, USA; Division of Gastroenterology & Hepatology and Comprehensive Transplant Center, Northwestern University, Chicago, IL, USA. Electronic address:

View Article and Full-Text PDF

We Are Not Immune: Racial and Ethnic Disparities in Autoimmune Liver Diseases.

Hepatology 2021 May 31. Epub 2021 May 31.

USC Research Center for Liver Diseases, Keck School of Medicine, University of Southern California, Los Angeles California, USA.

Autoimmune liver diseases are attributed to a complex interplay of biologic, acquired, and environmental factors. Increased prevalence, later stage of presentation, worse response to standard therapy, and transplant-related disparities have all been reported in racial and ethnic minorities such as Black and Latinx patients with autoimmune liver diseases. While biology and inherited genetic predispositions may partly explain these disparities, definitive and universal genetic variations underlying these differences in outcomes have not been defined. Read More

View Article and Full-Text PDF

Single-Center North American Experience of Liver Transplantation in Autoimmune Hepatitis: Infrequent Indication but Good Outcomes for Patients.

J Can Assoc Gastroenterol 2021 Jun 20;4(3):137-144. Epub 2020 Jul 20.

Multi-Organ Transplant Program, University Health Network, Toronto, Ontario, Canada.

Background And Aims: A 40% risk of disease recurrence post-liver transplantation (LT) for autoimmune hepatitis (AIH) has been previously reported. Risk factors for recurrence and its impact on long-term patient outcome are poorly defined. We aimed to assess prevalence, time to disease recurrence, as well as patient and graft survival in patients with recurrent AIH (rAIH) versus those without recurrence. Read More

View Article and Full-Text PDF

Therapeutic Effects of Naringin in Rheumatoid Arthritis: Network Pharmacology and Experimental Validation.

Front Pharmacol 2021 14;12:672054. Epub 2021 May 14.

Department of Joint Surgery, Xi'an Jiaotong University Affiliated HongHui Hospital, Xi'an, China.

Rheumatoid arthritis is a chronic autoimmune disease characterized by persistent hyperplasia of the synovial membrane and progressive erosion of articular cartilage. Disequilibrium between the proliferation and death of RA fibroblast-like synoviocytes (RA-FLSs) is the critical factor in progression of RA. Naringin has been reported to exert anti-inflammatory and antioxidant effect in acute and chronic animal models of RA. Read More

View Article and Full-Text PDF