12,168 results match your criteria Autoimmune Hepatitis

Transplantation for EASL-CLIF and APASL acute-on-chronic liver failure (ACLF) patients: The to evaluate long-term post-Transplant outcomes.

EClinicalMedicine 2022 Jul 4;49:101476. Epub 2022 Jun 4.

Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.

Background: The forecast accuracy of the European Association for the Study of the Liver-Chronic Liver Failure (EASL-CLIF) and Asian Pacific Association for the Study of the Liver (APASL) acute-on-chronic liver failure (ACLF) criteria in assessing long-term outcomes after liver transplantation (LT) is still unclear, especially when the staging of the two standards is inconsistent.

Methods: A retrospective cohort () including 565 patients from January 2015 to June 2021 was conducted. The 28 and 90 days, 1- and 3-years overall survival (OS) after LT were compared between different grades. Read More

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Gender and Autoimmune Liver Diseases: Relevant Aspects in Clinical Practice.

J Pers Med 2022 Jun 2;12(6). Epub 2022 Jun 2.

IRCCS Negrar, 37024 Verona, Italy.

Autoimmune liver diseases (AILDs) include autoimmune hepatitis, primary biliary cholangitis and primary sclerosing cholangitis. The etiologies of AILD are not well understood but appear to involve a combination of genetic and environmental factors. AILDs commonly affect young individuals and are characterized by a highly variable clinical course. Read More

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Spontaneous Myocarditis in Mice Predisposed to Autoimmune Disease: Including Vaccination-Induced Onset.

Biomedicines 2022 Jun 18;10(6). Epub 2022 Jun 18.

National Hospital Organization Kyoto Medical Centre, Kyoto 612-8555, Japan.

Nonobese diabetic (NOD)/ShiLtJ mice, such as biobreeding rats, are used as an animal model for type 1 diabetes. Diabetes develops in NOD mice as a result of insulitis, a leukocytic infiltrate of the pancreatic islets. The onset of diabetes is associated with moderate glycosuria and nonfasting hyperglycemia. Read More

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HERACLIS-TAF: a multicentre prospective cohort study on 2-year safety and efficacy of tenofovir alafenamide in patients with chronic hepatitis B with renal and/or bone disorders or risks.

Aliment Pharmacol Ther 2022 Jun 23. Epub 2022 Jun 23.

Department of Medicine and Research Laboratory of Internal Medicine, National and European (ERN-Rare Liver) Expertise Center in Autoimmune Liver Diseases, General University Hospital of Larissa, Larissa, Greece.

Background: Tenofovir alafenamide (TAF) has exhibited a favourable safety profile on estimated glomerular filtration (eGFR) and bone mineral density (BMD) , but has not been extensively studied in patients with renal impairment and/or BMD disorders.

Aim: To assess predictors of eGFR changes and other safety and efficacy outcomes during 24-month TAF therapy in patients with chronic hepatitis B with renal and/or BMD disorders/risks.

Methods: Adult patients who started TAF at 13 clinics throughout Greece were prospectively included. Read More

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Phase I study of adjuvant immunotherapy with autologous tumor-infiltrating lymphocytes in locally advanced cervical cancer.

J Clin Invest 2022 Jun 21. Epub 2022 Jun 21.

Department of Biotherapy, Sun Yat-sen University Cancer Center, Guangzhou, China.

Background: Adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TILs) has achieved remarkable clinical efficacy in metastatic cancers such as melanoma and cervical cancer (CC). Here we explored the safety, feasibility and preliminary tumor response and performed translational investigations of adjuvant immunotherapy using infusion of autogenous (auto)-TILs following concurrent chemoradiotherapy (CCRT) in CC patients with locally advanced disease.

Methods: Twenty-seven CC patients with stage III to IV disease were recruited in this single-center, phase I study. Read More

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Challenge of hepatitis B testing following intravenous immunoglobulin therapy in patients with autoimmune skin diseases.

J Dermatol 2022 Jun 21. Epub 2022 Jun 21.

Department of Dermatology, University of Lübeck, Lübeck, Germany.

Intravenous immunoglobulin (IVIg) contains pooled immunoglobulins from the plasma of healthy blood donors. All plasma samples are tested for HIV, hepatitis viruses (A, B, and C), and parvovirus B19. As part of this screening step, nucleic acid amplification technology (NAT) is used and allows the presence of specific antibodies targeting viral structures that are commonly used to test for infection status, such as anti-hepatitis B surface antigen (HBs) or anti-hepatitis B virus core (HBc) antibodies. Read More

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The association between chronic liver diseases and preeclampsia.

BMC Pregnancy Childbirth 2022 Jun 20;22(1):500. Epub 2022 Jun 20.

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Preeclampsia is a multisystem disorder characterized by an abnormal vascular response to placentation associated with increased systemic vascular resistance. As liver involvement is one of the main clinical features of preeclampsia, we sought to determine if there is an association between chronic liver diseases and preeclampsia.

Methods: A retrospective matched case-control analysis was conducted in a tertiary medical center. Read More

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Mouse Models of Liver Parenchyma Injuries and Regeneration.

Front Cell Dev Biol 2022 5;10:903740. Epub 2022 May 5.

Department of General Surgery, Ji'an Hospital, Shanghai East Hospital, School of Medicine, Tongji University, Ji'an, China.

Mice have genetic and physiological similarities with humans and a well-characterized genetic background that is easy to manipulate. Murine models have become the most favored, robust mammalian systems for experimental analyses of biological processes and disease conditions due to their low cost, rapid reproduction, a wealth of mouse strains with defined genetic conditions (both native ones as well as ones established experimentally), and high reproducibility with respect to that which can be done in experimental studies. In this review, we focus on murine models for liver, an organ with renown regenerative capacity and the organ most central to systemic, complex metabolic and physiological functions for mammalian hosts. Read More

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Pediatric acute viral hepatitis with atypical variants: Clinical dilemmas and natural history.

World J Hepatol 2022 May;14(5):944-955

Division of Pediatric Gastroenterology, Apollo BGS Hospitals, Mysuru 570023, Karnataka, India.

Classical acute viral hepatitis (AVH) has an uncomplicated outcome. Acute liver failure has a grave prognosis. Atypical manifestations of AVH are a group of disorders that causes significant morbidity and dilemmas in children. Read More

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AhR Activation Leads to Attenuation of Murine Autoimmune Hepatitis: Single-Cell RNA-Seq Analysis Reveals Unique Immune Cell Phenotypes and Gene Expression Changes in the Liver.

Front Immunol 2022 3;13:899609. Epub 2022 Jun 3.

Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, SC, United States.

The aryl hydrocarbon receptor (AhR) is a ubiquitously expressed ligand-activated transcription factor. While initially identified as an environmental sensor, this receptor has been shown more recently to regulate a variety of immune functions. AhR ligands vary in structure and source from environmental chemicals such as 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and indoles found in cruciferous vegetables to endogenous ligands derived from tryptophan metabolism. Read More

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2022 International Autoimmune Hepatitis Group non-response criteria in autoimmune hepatitis: a too early endpoint?

J Hepatol 2022 Jun 15. Epub 2022 Jun 15.

Gastroenterology Department, Centro Hospitalar Universitário de São João, Porto, Portugal; Faculty of Medicine of the University of Porto, Porto, Portugal.

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Autoimmune hepatitis with history of HCV treatment triggered by COVID-19 vaccination: case report and literature review.

Clin J Gastroenterol 2022 Jun 18. Epub 2022 Jun 18.

Department of Gastroenterology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki, 305-8575, Japan.

Although vaccines have been effective against the worldwide pandemic of Coronavirus Disease 19 (COVID-19), some case reports have described autoimmune hepatitis triggered by COVID-19 vaccination. Meanwhile, hepatitis C virus (HCV) is known to be related to autoimmune diseases. Here, we report a case of autoimmune hepatitis with history of HCV treatment triggered by COVID-19 vaccination. Read More

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Editorial: Acute Hepatitis of Unknown Origin in Children. Is Autoimmunity at Play?

Med Sci Monit 2022 Jun 4;28:e937371. Epub 2022 Jun 4.

Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.

A recent global outbreak of cases of acute hepatitis of unknown origin in children has raised health alerts. Increasing numbers of cases are being reported in most countries, mainly in the United Kingdom (UK). Although the cause remains unknown, several viruses have been isolated from affected children, including adenovirus, severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2), Epstein-Barr virus (EBV), and rhinovirus. Read More

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Clinical Outcomes and Inpatient Mortality Among Hospitalized Patients With Concomitant Autoimmune Hepatitis and Systemic Lupus Erythematosus.

Cureus 2022 May 13;14(5):e24981. Epub 2022 May 13.

Gastroenterology and Hepatology, Jersey City Medical Center, Jersey City, USA.

Background Autoimmune hepatitis (AIH) is an inflammatory disease of the liver that is characterized by a broad disease spectrum, circulating autoantibodies, and elevated serum globulin levels. Systemic lupus erythematosus (SLE) is a chronic disease that is characterized by a high inflammatory state and is associated with multiorgan system involvement. Despite a well-known association between AIH and other autoimmune diseases, the literature is deficient on the associations between AIH-related outcomes and complications in SLE patients. Read More

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Concurrent de novo Thymoma-associated Paraneoplastic Type 1 Autoimmune Hepatitis and Pure Red Cell Aplasia After Thymectomy: A Case Report and Literature Review.

Intern Med 2022 Jun 14. Epub 2022 Jun 14.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Japan.

The precise manipulation of immune tolerance is the holy grail of immunotherapies for both autoimmunity and cancer immunity. Thymomas are well known to be associated with autoimmune diseases. The exact mechanism by which autoreactivity is induced after thymectomy remains to be elucidated. Read More

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Anti-Proteinase 3 Antibodies as a Biomarker for Ulcerative Colitis and Primary Sclerosing Cholangitis in Children.

J Pediatr Gastroenterol Nutr 2022 Apr 24;74(4):463-470. Epub 2021 Nov 24.

Institute of Immunology, Technische Universität Dresden, Dresden, Germany.

Objectives: Anti-neutrophil cytoplasmic antibody (ANCA) directed against proteinase 3 (PR3) is a marker for granulomatosis with polyangiitis, but is also found in patients with inflammatory bowel disease (IBD), mainly ulcerative colitis (UC). The aim of our study was to investigate ANCA and PR3-ANCA in paediatric IBD.

Methods: We tested 326 paediatric IBD patients and 164 controls for anti-Saccharomyces cerevisiae antibodies (ASCA), ANCA (indirect immunofluorescence, IIF) and PR3-ANCA (chemiluminescence immunoassay). Read More

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-Propargyl-cysteine prevents concanavalin A-induced immunological liver injury in mice.

Pharm Biol 2022 Dec;60(1):1169-1176

Shanghai Key Laboratory of Bioactive Small Molecules, School of Pharmacy, Fudan University, Shanghai, China.

Context: -Propargyl-cysteine (SPRC), an endogenous HS modulator, exerts anti-inflammatory effects on cardiovascular and neurodegenerative disease, but it remains unknown whether SPRC can prevent autoimmune hepatitis.

Objective: To evaluate the preventive effect of SPRC on concanavalin A (Con A)-induced liver injury and uncover the underlying mechanisms.

Materials And Methods: Mice were randomly divided into five groups: control, Con A, SPRC (5 and 10 mg/kg injected intravenously once a day for 7 days), and propargylglycine (PAG; 50 mg/kg injected intraperitoneally 0. Read More

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December 2022

Development of hepatitis triggered by SARS-CoV-2 vaccination in patient with cancer during immunotherapy: a case report.

Immunotherapy 2022 Jun 13. Epub 2022 Jun 13.

Division of Infectious Diseases I, Fondazione IRCCS Policlinico San Matteo, Pavia, 27100, Italy.

Patients with cancer have a higher risk of severe COVID-19, and expert consensus advocates for COVID-19 vaccination in this population. Some cases of autoimmune hepatitis have been described after the administration of COVID-19 vaccine in the people in apparently good health. Immune checkpoint inhibitors (ICIs) are responsible for a wide spectrum of immune-related adverse events (irAEs). Read More

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Safety and efficacy of budesonide during pregnancy in women with autoimmune hepatitis.

J Gastrointestin Liver Dis 2022 Jun 12;31(2):256-257. Epub 2022 Jun 12.

Division of Hepatology, Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim; Clinical Cooperation Unit Healthy Metabolism, Center for Preventive Medicine and Digital Health Baden-Württemberg (CPDBW), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

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Autoimmune polyendocrine syndrome type 1: Clinical manifestations, pathogenetic features, and management approach.

Autoimmun Rev 2022 Jun 9;21(8):103135. Epub 2022 Jun 9.

Semey Medical University, Semey, Kazakhstan; CONEM Kazakhstan Environmental Health and Safety Research Group, Semey Medical University, Semey, Kazakhstan.

Autoimmune polyendocrine syndrome type 1 (APS-1) is an autosomal recessive hereditary pathology that develops with endocrine and non-endocrine manifestations in childhood. The classic triad of APS-1 includes chronic candidiasis of the skin and mucous membranes, adrenal insufficiency, and hypoparathyroidism. APS-1 is often accompanied by hypogonadism, type 1 diabetes, autoimmune thyroiditis, vitiligo, alopecia, asplenia, pneumonitis, gastritis, pernicious anemia, and intestinal dysfunction, nephritis, and hepatitis. Read More

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Editorial: acute severe autoimmune hepatitis-a diagnostic and therapeutic dilemma.

Aliment Pharmacol Ther 2022 07;56(1):170-171

Department of Gastroenterology, Harran University, Şanlıurfa, Turkey.

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Autoimmune hepatitis: Challenges and novelties.

Med Clin (Barc) 2022 Jun 7. Epub 2022 Jun 7.

Servicio de Hepatología, Hospital Clínic, Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, España. Electronic address:

Autoimmune hepatitis is a chronic inflammatory disease of the liver. The etiology is partly unknown and commonly affects women of all ages. It is characterized by increase in transaminase and immunoglobulin G levels, autoantibodies, and portal inflammatory infiltrate with interface hepatitis in the liver biopsy. Read More

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Challenges and Future of Drug-Induced Liver Injury Research-Laboratory Tests.

Int J Mol Sci 2022 May 27;23(11). Epub 2022 May 27.

Department of Medicine II, Liver Centre Munich, LMU Klinikum Munich, 81377 Munich, Germany.

Drug-induced liver injury (DILI) is a rare but potentially severe adverse drug event, which is also a major cause of study cessation and market withdrawal during drug development. Since no acknowledged diagnostic tests are available, DILI diagnosis poses a major challenge both in clinical practice as well as in pharmacovigilance. Differentiation from other liver diseases and the identification of the causative agent in the case of polymedication are the main issues that clinicians and drug developers face in this regard. Read More

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Dual-readout immunosensor based on multifunctional MXene probe triggers the signal amplification for detection of autoimmune hepatitis marker.

Mikrochim Acta 2022 06 9;189(7):248. Epub 2022 Jun 9.

College of Chemistry and Material, Fujian Normal University, Fuzhou, 350108, Fujian, China.

A dual-readout immunosensor coupled with electrochemical impedance and temperature signal was successfully proposed to detect autoimmune hepatitis markers (ASGPR). NbC MXene with excellent conductivity, abundant surface functional groups, and extraordinary photothermal conversion efficiency, was designed to be a multifunctional biological probe, whose specific binding with antigen enhanced steric hindrance to generate electrochemical impedance signal, and at the same time, it had a strong optical response in the near-infrared band to achieve temperature output. In addition, poly(N-isopropyl acrylamide) (PNIPAM) was a temperature-sensitive polymer, which was adopted as the sensing matrix. Read More

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Severe childhood lichen planus pemphigoides after hepatitis A vaccination.

Skin Health Dis 2022 Jun 19;2(2):e94. Epub 2022 Jan 19.

Department of Dermatology Farhat Hached Hospital of Sousse Sousse Tunisia.

Background: Lichen planus (LP) pemphigoides (LPP) is a very rare autoimmune bullous disorder, that is, exceptional in children.

Case Report: We report a case of LP pemphigoides with severe cutaneous and mucosal involvement in an 8-year-old girl who consulted for multiple vesicular and bullous lesions associated with shiny erythematous-purple plaques. The eruption occurred 2 months after vaccination against hepatitis A virus. Read More

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Circulating complement factor H levels are associated with disease severity and relapse in autoimmune hepatitis.

JHEP Rep 2022 Jul 29;4(7):100497. Epub 2022 Apr 29.

Department of Gastroenterology, Fukushima Medical University, Fukushima, Japan.

Background & Aims: The complement system plays pivotal roles in innate immunity. Mannose-binding lectin-associated serine protease (MASP)-2 plays essential roles in the activation of the lectin complement pathway. Complement factor H acts as a critical negative regulator of the alternative complement pathway. Read More

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Immune Characteristics in Biliary Atresia Based on Immune Genes and Immune Cell Infiltration.

Front Pediatr 2022 23;10:902571. Epub 2022 May 23.

Department of Hepatobiliary Surgery Children's Hospital of Chongqing Medical University, Chongqing Key Laboratory of Pediatrics, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China.

Background: Biliary atresia (BA) is a serious biliary disease in infancy. Jaundice is the most visual and prominent symptom, and it mainly involves bile duct cells leading to the loss of intrahepatic and extrahepatic bile ducts. If left untreated, it will eventually progress to liver cirrhosis. Read More

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Clinical utility of two-dimensional shear-wave elastography in monitoring disease course in autoimmune hepatitis-primary biliary cholangitis overlap syndrome.

World J Gastroenterol 2022 May;28(18):2021-2033

Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.

Background: Autoimmune hepatitis-primary biliary cholangitis (AIH-PBC) overlap syndrome has a worse prognosis than AIH or PBC alone. Therefore, accurately staging liver fibrosis and dynamically monitoring disease progression are essential.

Aim: To investigate the performance of two-dimensional shear-wave elastography (2D-SWE) for noninvasively staging liver fibrosis and assessing the clinical utility of repeated 2D-SWE for monitoring treatment response in AIH-PBC overlap syndrome. Read More

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Prevalence of Primary Biliary Cholangitis in a Cohort of Primary Sjögren's Syndrome Patients.

Cureus 2022 Apr 29;14(4):e24590. Epub 2022 Apr 29.

Clinical Immunology Unit, Centro Hospitalar Universitário do Porto, Porto, PRT.

Objective To analyze the prevalence and clinical progression of primary biliary cholangitis (PBC) in patients with primary Sjögren's syndrome (pSS) and possible associations between biochemical and immunological features and the development of PBC. Methods We retrospectively reviewed a cohort of 115 pSS patients followed up in an outpatient clinic from 1987 to 2020, without a history of liver disease, and looked for the presence of PBC through analysis of several biochemical, immunological, and histologic characteristics. Results Twenty patients (17. Read More

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