128 results match your criteria Auto- immunity highlights[Journal]


Recurrent angioedema, Guillain-Barré, and myelitis in a girl with systemic lupus erythematosus and CD59 deficiency syndrome.

Auto Immun Highlights 2020 Dec 29;11(1). Epub 2020 Jun 29.

Department of Pediatric Neurology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: CD59 deficiency is a congenital mutation disorder in complement pathway which can present with various manifestations.

Case Presentation: Herein, we presented an adolescent 16-years-old girl with recurrent attacks of Guillain-Barre in early childhood and then recurrent attacks of angioedema, paresthesia, and myelitis. Finally, she presented with quadriplegia, malar rash, proteinuria, lymphopenia, and high titer of antinuclear antibody. Read More

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http://dx.doi.org/10.1186/s13317-020-00132-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322911PMC
December 2020

Profiles of criteria and non-criteria anti-phospholipid autoantibodies are associated with clinical phenotypes of the antiphospholipid syndrome.

Auto Immun Highlights 2020 Dec 15;11(1). Epub 2020 May 15.

1Clinical Immunology, Angioedema and Allergy Unit, Zabludowicz Center for Autoimmune Diseases, The Chaim Sheba Medical Center, Tel-Hashomer, 52621 Israel.

Background: Specific anti-phospholipids antibodies (aPLs) are used as classification criteria of the antiphospholipid syndrome (APS). These aPLs, although essential for diagnosis, do not predict disease phenotypes, which may require specific therapies. Non-criteria aPLs are rarely evaluated and their role is yet to be defined. Read More

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http://dx.doi.org/10.1186/s13317-020-00131-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229627PMC
December 2020

A comprehensive analysis of antigen-specific autoimmune liver disease related autoantibodies in patients with multiple sclerosis.

Auto Immun Highlights 2020 Dec 10;11(1). Epub 2020 Apr 10.

2Department of Rheumatology and Clinical Immunology, University General Hospital of Larissa, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis, Larissa 40500 Greece.

Introduction: Abnormal liver function tests are frequently seen in patients with multiple sclerosis (MS) and their origin at times is attributed to the possible co-occurrence or the de novo induction of autoimmune liver diseases (AILD), namely autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC), but comprehensive analysis of AILD-related autoantibody has not been carried out.

Aim: To assess the presence of AILD-related autoantibodies in a well-defined cohort of MS patients, and to assess their clinical significance.

Materials And Methods: 133 MS (93 female) patients (102 RRMS, 27 SPMS, and 5 PPMS), mean age 42. Read More

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http://dx.doi.org/10.1186/s13317-020-00130-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147023PMC
December 2020

Association of polymorphism and multiple sclerosis in Malaysia: a pilot study.

Auto Immun Highlights 2019 Dec 17;10(1):13. Epub 2019 Dec 17.

Autoimmune Unit, Allergy and Immunology Research Centre, Institute for Medical Research, National Institute of Health, Selangor, Malaysia.

Background: Multiple sclerosis is an immune mediated disease targeting the central nervous system. Association of non-human leukocyte antigen gene, , with multiple sclerosis has been reported in several populations but is unclear among Southeast Asians. This pilot study was conducted to explore the association between polymorphism and multiple sclerosis among the Malay population in Malaysia. Read More

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http://dx.doi.org/10.1186/s13317-019-0123-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065364PMC
December 2019

HERV-K and HERV-W transcriptional activity in myalgic encephalomyelitis/chronic fatigue syndrome.

Auto Immun Highlights 2019 Dec 15;10(1):12. Epub 2019 Nov 15.

1Laboratório de Virologia, Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, Rua Dr. Enéas de Carvalho Aguiar, 470, São Paulo, SP 05403-000 Brazil.

Background: Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/MS) is an incapacitating chronic disease that dramatically compromise the life quality. The CFS/ME pathogenesis is multifactorial, and it is believed that immunological, metabolic and environmental factors play a role. It is well documented an increased activity of Human endogenous retroviruses (HERVs) from different families in autoimmune and neurological diseases, making these elements good candidates for biomarkers or even triggers for such diseases. Read More

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http://dx.doi.org/10.1186/s13317-019-0122-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065355PMC
December 2019

Preclinical studies on the toxicology, pharmacokinetics and safety of K1-70 a human monoclonal autoantibody to the TSH receptor with TSH antagonist activity.

Auto Immun Highlights 2019 Dec 7;10(1):11. Epub 2019 Nov 7.

AV7 Limited, FIRS Laboratories, Parc Ty Glas, Llanishen, Cardiff, CF14 5DU UK.

Background: The human monoclonal autoantibody K1-70™ binds to the TSH receptor (TSHR) with high affinity and blocks TSHR cyclic AMP stimulation by TSH and thyroid stimulating autoantibodies.

Methods: The preclinical toxicology assessment following weekly intravenous (IV) or intramuscular (IM) administration of K1-70™ in rats and cynomolgus monkeys for 29 days was carried out. An assessment of delayed onset toxicity and/or reversibility of toxicity was made during a further 4 week treatment free period. Read More

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http://dx.doi.org/10.1186/s13317-019-0121-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065368PMC
December 2019

Evolving liver inflammation in biochemically normal individuals with anti-mitochondria antibodies.

Auto Immun Highlights 2019 Dec 31;10(1):10. Epub 2019 Oct 31.

1Rheumatology Division, Universidade Federal de São Paulo, UNIFESP, Rua Botucatu 740, São Paulo, SP 04023-900 Brazil.

Background: Anti-mitochondria autoantibodies (AMA) occur in > 95% primary biliary cholangitis (PBC) patients. Biochemically normal AMA-positive (BN/AMA+) individuals, occasionally noticed by indirect immunofluorescence (IIF) on HEp-2 cells and confirmed in AMA-specific assays, may represent early stages of PBC. The Enhanced Liver Fibrosis (ELF) score is a surrogate marker for liver fibrosis. Read More

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http://dx.doi.org/10.1186/s13317-019-0120-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065335PMC
December 2019

Antiphospholipid syndrome: a case report with an unusual wide spectrum of clinical manifestations.

Auto Immun Highlights 2019 Dec 19;10(1). Epub 2019 Oct 19.

Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", Piazza Giulio Cesare 11, 70124 Bari, Italy.

Background: Antiphospholipid syndrome (APS) is an autoimmune disease characterized by the occurrence of venous and/or arterial thrombosis, and the detection of circulating antiphospholipid antibodies. The classification criteria for definite APS are actually met when at least one clinical criterion (thrombosis or pregnancy morbidity) is present in association of one laboratory criterion (LAC, aCL antibody or aβ2GPI antibody present on two or more occasions, at least 12 weeks a part), and thrombosis should be confirmed by objective validated criteria. The average age of primary APS patients has been reported to be about 35-40 years and the disease is more common in women than in men. Read More

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http://dx.doi.org/10.1186/s13317-019-0119-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065311PMC
December 2019

Look granulomatosis with polyangiitis (GPA) straight in the face: missed opportunities leading to a delayed diagnosis.

Auto Immun Highlights 2019 Dec 17;10(1). Epub 2019 Sep 17.

1Department of Medicine, Division of Rheumatology, University of New Mexico School of Medicine, Albuquerque, NM 87131 USA.

Granulomatosis with polyangiitis (GPA) is a systemic vasculitis with a potential to involve any organ system. It remains an important cause of kidney related morbidity and mortality. Early diagnosis can be difficult and requires high index of suspicion in all patients, but especially in cases with atypical presentation. Read More

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http://dx.doi.org/10.1186/s13317-019-0118-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065353PMC
December 2019

Brain atrophy in multiple sclerosis: mechanisms, clinical relevance and treatment options.

Auto Immun Highlights 2019 Dec 10;10(1). Epub 2019 Aug 10.

1Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, University Hospital of Larissa, Biopolis, Mezourlo Hill, 41100 Larissa, Greece.

Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system characterized by focal or diffuse inflammation, demyelination, axonal loss and neurodegeneration. Brain atrophy can be seen in the earliest stages of MS, progresses faster compared to healthy adults, and is a reliable predictor of future physical and cognitive disability. In addition, it is widely accepted to be a valid, sensitive and reproducible measure of neurodegeneration in MS. Read More

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http://dx.doi.org/10.1186/s13317-019-0117-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065319PMC
December 2019

The clinical significance of atypical indirect immunofluorescence patterns on primate cerebellum in paraneoplastic antibody screening.

Auto Immun Highlights 2019 Dec 25;10(1). Epub 2019 Jul 25.

1Department of Neurosciences, Laboratory for Molecular Neurobiomarker Research, KU Leuven (University of Leuven), Herestraat 49, 3000 Leuven, Belgium.

Purpose: Screening for paraneoplastic antibodies is often performed by means of indirect immunofluorescence on primate cerebellar slices. However, immunofluorescence patterns, i.e. Read More

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http://dx.doi.org/10.1186/s13317-019-0116-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065332PMC
December 2019

A new M23-based ELISA assay for anti-aquaporin 4 autoantibodies: diagnostic accuracy and clinical correlation.

Auto Immun Highlights 2019 Dec 19;10(1). Epub 2019 Jun 19.

4Laboratory of Clinical Pathology, San Antonio Hospital, Azienda Sanitaria Universitaria Integrata di Udine, Udine, Italy.

Purpose: Although many assays have been developed to detect anti-aquaporin-4 (AQP4) antibodies, most of these assays require sophisticated techniques and are thus only available at specialized laboratories. The aim of this study was to evaluate the analytical and clinical performance of a new commercial enzyme-linked immunosorbent assay (ELISA RSR, AQP4 Ab Version 2) to detect anti-AQP4 antibodies performed on a fully automated system (SkyLAB 752).

Methods: Serum samples from 64 patients with neuromyelitis optica spectrum disorders (NMOSD) (including NMO, longitudinally extensive myelitis-LETM, optical neuritis and myelitis) and 27 controls were tested for anti-AQP4 antibodies. Read More

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http://dx.doi.org/10.1186/s13317-019-0115-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065340PMC
December 2019

Neutrophil/lymphocyte ratio and lymphocyte/monocyte ratio in ulcerative colitis as non-invasive biomarkers of disease activity and severity.

Auto Immun Highlights 2019 Dec 15;10(1). Epub 2019 May 15.

1Department of Internal Medicine, Clinical Immunology and Allergy, Ain Shams University, Cairo, Egypt.

Background: Apart from endoscopic interventions, readily attainable cost-effective biomarkers for ulcerative colitis (UC) assessment are required. For this purpose, we evaluated differential leucocytic ratio, mainly neutrophil-lymphocyte ratio (NLR) and lymphocyte-monocyte ratio (LMR) as simple available indicators of disease activity in patients with ulcerative colitis.

Methods: Study conducted on 80 UC patients who were classified into two groups of 40 each according to Mayo score and colonoscopic findings. Read More

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http://dx.doi.org/10.1186/s13317-019-0114-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909025PMC
December 2019

Anti-β2-glycoprotein I and anti-phosphatidylserine/prothrombin antibodies exert similar pro-thrombotic effects in peripheral blood monocytes and endothelial cells.

Auto Immun Highlights 2019 Dec 6;10(1). Epub 2019 Apr 6.

2Department of Laboratory Medicine, Institute of Clinical Pathology, University Hospital of Udine, Via Chiusaforte, Ingresso H, 33100 Udine, Italy.

Purpose: The introduction of the anti-phosphatidylserine/prothrombin (aPS/PT) antibodies among the routinely investigated anti-phospholipid (aPL) antibodies led to an improvement in anti-phospholipid syndrome (APS) laboratory diagnostic performance; however, their pathogenic mechanism is still substantially undefined. To support clinical data and future inclusion as possible new criteria antibodies, we designed a head-to-head study to directly compare the procoagulant effects sustained in vitro by aPS/PT to those sustained by anti-β2-glycoprotein I (aβ2GpI) domain 1-specific antibodies.

Methods: Blood donors-derived monocytes and endothelial cells (HUVEC) were stimulated with lipopolysaccharides (LPS) alone or in combination with the IgG fractions isolated from the serum of six APS patients, positive only for aβ2GpI or for aPS/PT antibodies. Read More

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http://dx.doi.org/10.1186/s13317-019-0113-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909027PMC
December 2019

The search for the Holy Grail: autoantigenic targets in primary sclerosing cholangitis associated with disease phenotype and neoplasia.

Auto Immun Highlights 2020 Mar 16;11(1). Epub 2020 Mar 16.

Institute of Biotechnology, Faculty Environment and Natural Sciences, Brandenburg University of Technology Cottbus-Senftenberg, Senftenberg, Germany.

Unlike in other autoimmune liver diseases such as autoimmune hepatitis and primary biliary cholangitis, the role and nature of autoantigenic targets in primary sclerosing cholangitis (PSC), a progressive, chronic, immune-mediated, life threatening, genetically predisposed, cholestatic liver illness, is poorly elucidated. Although anti-neutrophil cytoplasmic antibodies (ANCA) have been associated with the occurrence of PSC, their corresponding targets have not yet been identified entirely. Genome-wide association studies revealed a significant number of immune-related and even disease-modifying susceptibility loci for PSC. Read More

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http://dx.doi.org/10.1186/s13317-020-00129-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077156PMC

Receptor autoimmunity: diagnostic and therapeutic implications.

Authors:
Renato Tozzoli

Auto Immun Highlights 2020 Jan 7;11(1). Epub 2020 Jan 7.

Laboratory of Clinical Pathology, S. Maria degli Angeli Hospital, and Consultant Endocrinologist, San Giorgio Clinics, Pordenone, Italy.

Receptor autoimmunity is one of the ways in which autoimmune diseases appear in humans. Graves' disease, myasthenia gravis, idiopathic membranous nephropathy, and autoimmune acute encephalitis are the major autoimmune diseases belonging to this particular group. Receptor autoimmune disease are dependent on the presence of autoantibodies directed against cell-surface antigens, namely TSH receptor in thyrocytes, acetylcholine receptor in neuromuscular junction, phospholipase 2 receptor in podocytes, and NMDA receptor in cortical neurons. Read More

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http://dx.doi.org/10.1186/s13317-019-0125-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065331PMC
January 2020

Anti-domain 1 β2 glycoprotein antibodies increase expression of tissue factor on monocytes and activate NK Cells and CD8+ cells in vitro.

Auto Immun Highlights 2020 Mar 2;11(1). Epub 2020 Mar 2.

Department of Immunology, Faculty of Medicine and Dentistry, Palacky University Olomouc and Faculty Hospital, Olomouc, Czech Republic.

Background: β2-Glycoprotein I (β2GPI) represents the major antigenic target for antiphospholipid antibodies (aPL), with domain 1 (D1) being identified as a risk factor for thrombosis and pregnancy complications in APS. We aimed to analyse the ability of aPL, and particularly anti-D1 β2GPI, to stimulate prothrombotic and proinflammatory activity of immune cells in vitro.

Methods: Peripheral blood mononuclear cells (PBMCs) from 11 healthy individuals were incubated with: (1) "anti-D1(+)"-pooled plasma derived from patients suspected of having APS contained anticardiolipin antibodies (aCL), lupus anticoagulant (LA), anti-β2GPI and anti-D1 β2GPI; (2) "anti-D1(-)"-pooled plasma from patients suspected of having APS contained aCL, LA, anti-β2GPI, and negative for anti-D1 β2GPI; (3) "seronegative"-negative for aPL. Read More

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http://dx.doi.org/10.1186/s13317-020-00128-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065342PMC

Associations between HLA and autoimmune neurological diseases with autoantibodies.

Auto Immun Highlights 2020 Jan 22;11(1). Epub 2020 Jan 22.

French Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis, Hospices Civils de Lyon, Hôpital Neurologique, 59 Boulevard Pinel, 69677, Bron Cedex, France.

Recently, several autoimmune neurological diseases have been defined by the presence of autoantibodies against different antigens of the nervous system. These autoantibodies have been demonstrated to be specific and useful biomarkers, and most of them are also pathogenic. These aspects have increased the value of autoantibodies in neurological practice, as they enable to establish more accurate diagnosis and to better understand the underlying mechanisms of the autoimmune neurological diseases when they are compared to those lacking them. Read More

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http://dx.doi.org/10.1186/s13317-019-0124-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065322PMC
January 2020

Twenty years of research on the DFS70/LEDGF autoantibody-autoantigen system: many lessons learned but still many questions.

Auto Immun Highlights 2020 Feb 3;11(1). Epub 2020 Feb 3.

Center for Health Disparities and Molecular Medicine, Loma Linda University School of Medicine, Loma Linda, CA, 92350, USA.

The discovery and initial characterization 20 years ago of antinuclear autoantibodies (ANAs) presenting a dense fine speckled (DFS) nuclear pattern with strong staining of mitotic chromosomes, detected by indirect immunofluorescence assay in HEp-2 cells (HEp-2 IIFA test), has transformed our view on ANAs. Traditionally, ANAs have been considered as reporters of abnormal immunological events associated with the onset and progression of systemic autoimmune rheumatic diseases (SARD), also called ANA-associated rheumatic diseases (AARD), as well as clinical biomarkers for the differential diagnosis of these diseases. However, based on our current knowledge, it is not apparent that autoantibodies presenting the DFS IIF pattern fall into these categories. Read More

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http://dx.doi.org/10.1186/s13317-020-0126-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065333PMC
February 2020

The perspective on standardisation and harmonisation: the viewpoint of the EASI president.

Authors:
Jan Damoiseaux

Auto Immun Highlights 2020 Feb 6;11(1). Epub 2020 Feb 6.

Central Diagnostic Laboratory, Maastricht University Medical Center, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands.

Standardisation of immuno-assays for autoantibodies is a major challenge. Although multiple organisations participate in the generation of internationally accepted standards, adequate standardisation of assays has not yet been achieved. Harmonisation may offer an alternative approach to better align requesting, testing, reporting and interpretation of autoimmune diagnostics. Read More

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http://dx.doi.org/10.1186/s13317-020-0127-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065346PMC
February 2020

Association of HLA-B27 and Behcet's disease: a systematic review and meta-analysis.

Auto Immun Highlights 2019 Mar 19;10(1). Epub 2019 Mar 19.

Tabriz Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: To calculate the genetic impact of the "HLA-B27" allele on the risk of Behcet's disease (BD) progression using a systematic review and meta-analysis on case control papers.

Methods: A systematic review search was conducted on the MeSH keywords of Behcet's disease, HLAB27 and B27 in PubMed, Scopus, ProQuest, EMBASE, SID, Magiran, IranDoc and IranMedex databases from 1975 to Aug 2017. Data underwent meta-analysis (random effect model) in CMA2 software. Read More

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http://dx.doi.org/10.1186/s13317-019-0112-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424999PMC
March 2019
2 Reads

Protective effect of TSLP and IL-33 cytokines in ulcerative colitis.

Auto Immun Highlights 2019 Mar 14;10(1). Epub 2019 Mar 14.

Gut and Liver Research Center, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran.

Purpose: Inflammatory bowel disease (IBD) primarily includes ulcerative colitis (UC) and Crohn's disease (CD). Thymic stromal lymphopoietin (TSLP) is a cytokine produced by intestinal epithelial cells (IECs) with immunomodulatory properties that plays an important role in the development of regulatory T cell (Treg) responses and tolerance in the gut. On the other hand, IL-33 has been considered as a cytokine with two different properties, inflammatory and anti-inflammatory functions, the latter may play a protective role against chronic intestinal inflammation. Read More

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http://dx.doi.org/10.1186/s13317-019-0110-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416230PMC
March 2019
5 Reads

Regulatory B and T lymphocytes in multiple sclerosis: friends or foes?

Auto Immun Highlights 2018 Nov 10;9(1). Epub 2018 Nov 10.

Department of Neurology and Laboratory of Neurogenetics, Faculty of Medicine, School of Health Sciences, University General Hospital of Larissa, University of Thessaly, Biopolis, 40500, Larissa, Greece.

Current clinical experience with immunomodulatory agents and monoclonal antibodies in principle has established the benefit of depleting lymphocytic populations in relapsing-remitting multiple sclerosis (RRMS). B and T cells may exert multiple pro-inflammatory actions, but also possess regulatory functions making their role in RRMS pathogenesis much more complex. There is no clear correlation of Tregs and Bregs with clinical features of the disease. Read More

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http://link.springer.com/10.1007/s13317-018-0109-x
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http://dx.doi.org/10.1007/s13317-018-0109-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230324PMC
November 2018
50 Reads

Performance analysis of automated evaluation of antinuclear antibody indirect immunofluorescent tests in a routine setting.

Auto Immun Highlights 2018 Sep 21;9(1). Epub 2018 Sep 21.

Central Diagnostic Laboratory, Maastricht University Medical Center, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands.

Purpose: Indirect immunofluorescence (IIF) on the human epithelial cell-line HEp-2 (or derivatives) serves as the gold standard in antinuclear antibody (ANA) screening. IIF, and its evaluation, is a labor-intensive method, making ANA testing a major challenge for present clinical laboratories. Nowadays, several automated ANA pattern recognition systems are on the market. Read More

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http://link.springer.com/10.1007/s13317-018-0108-y
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http://dx.doi.org/10.1007/s13317-018-0108-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147779PMC
September 2018
10 Reads

Remission of aggressive autoimmune disease (dermatomyositis) with removal of infective jaw pathology and ozone therapy: review and case report.

Authors:
Robert Jay Rowen

Auto Immun Highlights 2018 Jun 30;9(1). Epub 2018 Jun 30.

Private Medical Practice, 2200 County Center Dr. Ste C, Santa Rosa, CA, 95403, USA.

Introduction: This case uniquely reports a connection between endodontically infected teeth and systemic disease, and additionally presents ozone therapy as a unique therapy and immune system modulator. It is the world's first such reported case and the treatment holds invaluable lessons in assessing the "unknown" causes of autoimmunity and inflammation. Additionally, it presents ozone therapy as a most needed unique, non-toxic and powerful anti-infective agent, anti-inflammatory and immune modulator. Read More

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http://dx.doi.org/10.1007/s13317-018-0107-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026108PMC
June 2018
14 Reads

Anti-phospholipid IgG antibodies detected by line immunoassay differentiate patients with anti-phospholipid syndrome and other autoimmune diseases.

Auto Immun Highlights 2018 May 29;9(1). Epub 2018 May 29.

University of Brescia, Brescia, Italy.

Purpose: Anti-phospholipid antibodies (aPL) analyzed by line immunoassay (LIA) can recognize beta-glycoprotein I (βGPI) domain 1 (D1) epitopes depending on βGPI binding to distinct phospholipids. The aPL LIA was compared with consensus ELISA to investigate whether both techniques can discriminate anti-phospholipid syndrome (APS) patients from aPL-positive, systemic autoimmune rheumatic diseases (SARD) patients without clinical symptoms of APS and controls.

Methods: Thirty-four APS patients (14 arterial/venous thrombosis, 16 pregnancy morbidity, and 4 both), 41 patients with SARD lacking clinical APS criteria but demonstrating positivity for anti-βGPI (aβGPI) IgG, and 20 healthy subjects (HS) were tested for aPL to cardiolipin (aCL), phosphatidic acid, phosphatidylcholine, phosphatidylethanolamine, phosphatidylglycerol (aPG), phosphatidylinositol, phosphatidylserine, βGPI, prothrombin, and annexin V by LIA. Read More

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http://link.springer.com/10.1007/s13317-018-0106-0
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http://dx.doi.org/10.1007/s13317-018-0106-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975024PMC
May 2018
24 Reads

Rhabdomyolysis secondary to systemic lupus erythematosus.

Auto Immun Highlights 2018 Apr 6;9(1). Epub 2018 Apr 6.

Texas Tech University Health Sciences Center Amarillo School of Medicine, 1400 S Coulter St, Amarillo, TX, 79106, USA.

Systemic lupus erythematous (SLE) is a systemic auto-immune disorder with a variety of presentations and wide spread organ involvement. We present a case report of a patient with an SLE exacerbation as well as concurrent rhabdomyolysis with massively elevated CPK (304,700 U/L). Though a rarely reported effect of SLE, rhabdomyolysis can be severe and potentially lethal secondary or concurrent to an acute SLE episode. Read More

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http://link.springer.com/10.1007/s13317-018-0105-1
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http://dx.doi.org/10.1007/s13317-018-0105-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886906PMC
April 2018
44 Reads

Isolated acute lupus pneumonitis as the initial presentation of systemic lupus erythematosus in an 8-year-old girl.

Auto Immun Highlights 2018 Mar 27;9(1). Epub 2018 Mar 27.

Department of Radiology, Faculty of Medicine, Gazi University, Ankara, Turkey.

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease which has broad pleuropulmonary manifestations. One of the rare and mortal complications is acute lupus pneumonitis, which is reported very rarely, especially in childhood. Herein, we report an 8-year-old girl with isolated acute lupus pneumonitis as the initial presentation that required a lung biopsy for diagnosis. Read More

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http://dx.doi.org/10.1007/s13317-018-0104-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869323PMC
March 2018
15 Reads

Diagnostic accuracy of a new fluoroenzyme immunoassay for the detection of TSH receptor autoantibodies in Graves' disease.

Auto Immun Highlights 2018 Feb 12;9(1). Epub 2018 Feb 12.

Clinical Pathology Laboratory, S. Maria degli Angeli Hospital, Pordenone, Italy.

Purpose: Thyrotropin receptor (TSHR) autoantibodies (TRAbs) are a hallmark of Graves' disease (GD). The aim of this study was to evaluate the diagnostic accuracy of a new third generation automatic fluorescence enzyme immunoassay for TRAb measurement in GD, in comparison with two current IMAs.

Methods: Sera of 439 subjects (57 patients with untreated GD, 34 with treated GD, 15 with GD and Graves' orbitopathy, 52 with multinodular non-toxic goiter, 86 with Hashimoto's thyroiditis, 20 with toxic adenoma or toxic multinodular goiter, 55 with non-thyroid autoimmune diseases and 120 normal controls) were tested for TRAbs with the ELiA anti-TSH-R assay (ThermoFischer Scientific, Uppsala, Sweden), the TRAK RIA, Brahms (Thermo Scientific, Hennigsdorf, Germany) and the Immulite TSI assay (Siemens Healthcare, Llanberis, UK). Read More

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http://dx.doi.org/10.1007/s13317-018-0102-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809681PMC
February 2018
15 Reads

Platelet-activating factor acetylhydrolase in primary antiphospholipid syndrome.

Auto Immun Highlights 2018 Feb 10;9(1). Epub 2018 Feb 10.

Department of Cell Chemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Neutron Therapy Research Center and Collaborative Research Center for OMIC, Okayama University, Okayama, Japan.

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http://dx.doi.org/10.1007/s13317-018-0103-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812120PMC
February 2018
12 Reads

Role of vitamin D deficiency in systemic lupus erythematosus incidence and aggravation.

Auto Immun Highlights 2017 Dec 26;9(1). Epub 2017 Dec 26.

Talented Student Center, Student Research Committee, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, I.R., Iran.

Vitamin D is one of the main groups of sterols; playing an important role in phospho-calcic metabolism. The conversion of 7-dehydrocholesterol to pre- vitamin D3 in the skin, through solar ultraviolet B radiation, is the main source of vitamin D. Since lupus patients are usually photosensitive, the risk of developing vitamin D deficiency in is high in this population. Read More

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http://dx.doi.org/10.1007/s13317-017-0101-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743852PMC
December 2017
7 Reads
1 Citation

HLA-DQ2 and -DQ8 haplotypes frequency and diagnostic utility in celiac disease patients of Gaza strip, Palestine.

Auto Immun Highlights 2017 Nov 15;8(1):11. Epub 2017 Nov 15.

Faculty of Medicine, The Islamic University of Gaza, Gaza, Palestine.

Purpose: Celiac disease (CD) diagnosis can be established by serological and small bowel biopsy (SBB), while absence of HLA-DQ2 and -DQ8 haplotypes excludes the disease. The present study aims at evaluating the diagnosis of a representative sample of pediatric and adult CD patients of Gaza strip in light of DQ2 and DQ8 haplotypes expression.

Methods: Unrelated CD patients (n = 101) and matched healthy controls (n = 97) were genotyped for DQA1*05, DQB1*02 and DQB1*03:02 alleles by allele-specific real-time PCR. Read More

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http://dx.doi.org/10.1007/s13317-017-0099-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688040PMC
November 2017
17 Reads

Next-generation anti-CD20 monoclonal antibodies in autoimmune disease treatment.

Auto Immun Highlights 2017 Nov 16;8(1):12. Epub 2017 Nov 16.

Graduate Program in Immunology, Program in Biomedical Sciences, University of Michigan Medical School, Ann Arbor, USA.

The clinical success of anti-CD20 monoclonal antibody (mAb)-mediated B cell depletion therapy has contributed to the understanding of B cells as major players in several autoimmune diseases. The first therapeutic anti-CD20 mAb, rituximab, is a murine-human chimera to which many patients develop antibodies and/or experience infusion-related reactions. A second generation of anti-CD20 mAbs has been designed to be more effective, better tolerated, and of lower immunogenicity. Read More

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http://dx.doi.org/10.1007/s13317-017-0100-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688039PMC
November 2017
7 Reads

Personalized medicine in rheumatology: the paradigm of serum autoantibodies.

Auto Immun Highlights 2017 Dec 12;8(1):10. Epub 2017 Jul 12.

Division of Rheumatology and Clinical Immunology, Humanitas Research Hospital, Via A. Manzoni 56, Rozzano, 20089, Milan, Italy.

The sequencing of the human genome is now well recognized as the starting point of personalized medicine. Nonetheless, everyone is unique and can develop different phenotypes of the same disease, despite identical genotypes, as well illustrated by discordant monozygotic twins. To recognize these differences, one of the easiest and most familiar examples of biomarkers capable of identifying and predicting the outcome of patients is represented by serum autoantibodies. Read More

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http://dx.doi.org/10.1007/s13317-017-0098-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507804PMC
December 2017
15 Reads

Chemiluminescent immunoassay technology: what does it change in autoantibody detection?

Auto Immun Highlights 2017 Dec 24;8(1). Epub 2017 Jun 24.

Laboratorio di Patologia Clinica, Ospedale San Antonio, Azienda Sanitaria Universitaria Integrata di Udine, Tolmezzo, Italy.

Diagnostic technology is rapidly evolving, and over the last decade, substantial progress has been made even for the identification of antibodies, increasingly approaching this type of diagnostic to that of automated clinical chemistry laboratory. In this review, we describe the analytical and diagnostic characteristics of chemiluminescence technology in its strength and in its applicability for a more rapid and accurate diagnosis of autoimmune diseases. The wide dynamic range, greater than that of immunoenzymatic methods, the high sensitivity and specificity of the results expressed in quantitative form, the high degree of automation and the clinical implications related to the reduction in the turnaround time, and the ability to run a large number of antibody tests (even of different isotypes), directed towards large antigenic panels in random access mode, make this technology the most advanced in the clinical laboratory, with enormous repercussions on the workflow and on the autoimmunology laboratory organisation. Read More

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http://dx.doi.org/10.1007/s13317-017-0097-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483212PMC
December 2017
4 Reads

Definition of the upper reference limit for thyroglobulin antibodies according to the National Academy of Clinical Biochemistry guidelines: comparison of eleven different automated methods.

Auto Immun Highlights 2017 Dec 19;8(1). Epub 2017 Jun 19.

Clinical Pathology Laboratory, 'S. Maria degli Angeli' Hospital, Pordenone, Italy.

Purpose: In the last two decades, thyroglobulin autoantibodies (TgAb) measurement has progressively switched from marker of thyroid autoimmunity to test associated with thyroglobulin (Tg) to verify the presence or absence of TgAb interference in the follow-up of patients with differentiated thyroid cancer. Of note, TgAb measurement is cumbersome: despite standardization against the International Reference Preparation MRC 65/93, several studies demonstrated high inter-method variability and wide variation in limits of detection and in reference intervals. Taking into account the above considerations, the main aim of the present study was the determination of TgAb upper reference limit (URL), according to the National Academy of Clinical Biochemistry guidelines, through the comparison of eleven commercial automated immunoassay platforms. Read More

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http://dx.doi.org/10.1007/s13317-017-0096-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476530PMC
December 2017
4 Reads

Induction of IL-10 cytokine and the suppression of T cell proliferation by specific peptides from red cell band 3 and in vivo effects of these peptides on autoimmune hemolytic anemia in NZB mice.

Auto Immun Highlights 2017 Dec 28;8(1). Epub 2017 Apr 28.

School of Cellular and Molecular Medicine, University of Bristol, Biomedical Sciences Building, Bristol, BS8 1TD, UK.

Purpose: The anion channel protein band 3 is the main target of the pathogenic red blood cells (RBC) autoantibodies in New Zealand black (NZB) mice. CD4 T cells from NZB mice with autoimmune hemolytic anemia respond to band 3. Previously, we have shown that IL-10 and peptides containing a dominant T cell epitope from red cell band 3 modulate autoimmune hemolytic anemia in NZB mice. Read More

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http://dx.doi.org/10.1007/s13317-017-0095-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408328PMC
December 2017
2 Reads

A case of sarcoidosis with isolated hepatosplenic onset and development of inflammatory bowel disease during recovery stage.

Auto Immun Highlights 2017 Dec 28;8(1). Epub 2017 Apr 28.

Clinica Medica "Cesare Frugoni", Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", Piazza Giulio Cesare 11, 70124, Bari, Italy.

Sarcoidosis is a systemic disease characterized by an immune-mediated disorder, which leads to the development of non-caseating granulomas in the involved organs. More than 90% of patients with sarcoidosis present lungs and lymphatic system involvement at onset, while less than 10% has an isolated extrapulmonary localization. Here, we describe the case of an elderly patient with isolated hepato-splenic onset (multiple splenic lesions at imaging and cholestasis), and subsequent pulmonary involvement. Read More

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http://dx.doi.org/10.1007/s13317-017-0094-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408327PMC
December 2017
10 Reads

Exploring the plasmatic platelet-activating factor acetylhydrolase activity in patients with anti-phospholipid antibodies.

Auto Immun Highlights 2017 Dec 25;8(1). Epub 2017 Mar 25.

Department of Medical and Biological Sciences, University of Udine, Padiglione CSL - Via Chiusaforte, Ingresso F3, 33100, Udine, Italy.

Purpose: To explore the role of plasmatic platelet-activating factor acetylhydrolase (PAF-AH), a marker of cardiovascular risk, in patients with anti-phospholipid antibodies (aPL).

Methods: PAF-AH activity was assessed in a series of 167 unselected patients screened for aPL in a context of thrombotic events, risk of thrombosis or obstetric complications and in 77 blood donors.

Results: 116/167 patients showed positive results for at least one aPL among IgG/IgM anti-prothrombin/phosphatidylserine (aPS/PT), anti-cardiolipin (aCL), anti-beta2-glycoprotein I (aβ2GPI) or lupus anticoagulant (LAC), while 51/167 patients resulted aPL-negative. Read More

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http://dx.doi.org/10.1007/s13317-017-0092-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365449PMC
December 2017
6 Reads

The universe of ANA testing: a case for point-of-care ANA testing.

Auto Immun Highlights 2017 Dec 21;8(1). Epub 2017 Mar 21.

Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 1 University of New Mexico, Albuquerque, NM, 87131, USA.

Testing for total antinuclear antibodies (ANA) is a critical tool for diagnosis and management of autoimmune diseases at both the primary care and subspecialty settings. Repurposing of ANA from a test for lupus to a test for any autoimmune condition has driven the increase in ANA requests. Changes in ANA referral patterns include early or subclinical autoimmune disease detection in patients with low pre-test probability and use of negative ANA results to rule out underlying autoimmune disease. Read More

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http://dx.doi.org/10.1007/s13317-017-0093-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360668PMC
December 2017
17 Reads

Analysis of DFS70 pattern and impact on ANA screening using a novel HEp-2 ELITE/DFS70 knockout substrate.

Auto Immun Highlights 2017 Dec 17;8(1). Epub 2017 Mar 17.

Immco Diagnostics, A Trinity Biotech Company, 60 Pineview Drive, Buffalo, New York, 14228, USA.

Indirect immunofluorescence (IIF) using human epithelial cell (HEp-2) substrate is a widely used and the recommended method for screening of antinuclear antibodies (ANA). Dense fine speckled (DFS70) pattern on HEp-2 has been widely reported in various healthy and disease groups. Interpretation of DFS70 pattern can be challenging on a conventional HEp-2 substrate due to its similarity to some of the disease associated patterns. Read More

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http://dx.doi.org/10.1007/s13317-017-0091-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357240PMC
December 2017
1 Read

Structure and activation of the TSH receptor transmembrane domain.

Auto Immun Highlights 2017 Dec 5;8(1). Epub 2016 Dec 5.

FIRS Laboratories, RSR Ltd, Parc Ty Glas, Llanishen, Cardiff, CF14 5DU, UK.

Purpose: The thyroid-stimulating hormone receptor (TSHR) is the target autoantigen for TSHR-stimulating autoantibodies in Graves' disease. The TSHR is composed of: a leucine-rich repeat domain (LRD), a hinge region or cleavage domain (CD) and a transmembrane domain (TMD). The binding arrangements between the TSHR LRD and the thyroid-stimulating autoantibody M22 or TSH have become available from the crystal structure of the TSHR LRD-M22 complex and a comparative model of the TSHR LRD in complex with TSH, respectively. Read More

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http://dx.doi.org/10.1007/s13317-016-0090-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136658PMC
December 2017
71 Reads

Detection of autoantibodies to DSF70/LEDGFp75 in Mexican Hispanics using multiple complementary assay platforms.

Auto Immun Highlights 2017 Dec 24;8(1). Epub 2016 Nov 24.

Department of Basic Sciences, Center for Health Disparities and Molecular Medicine, Loma Linda University School of Medicine, Mortensen Hall 142, 11085 Campus St., Loma Linda, CA, 92350, USA.

Purpose: Antinuclear autoantibodies (ANA) targeting the dense fine speckled antigen DFS70, also known as lens epithelium-derived growth factor p75 (LEDGF/p75), are attracting attention due to their low frequency in systemic rheumatic diseases but increased frequency in clinical laboratory referrals and healthy individuals (HI). These ANA specifically recognize the stress protein DFS70/LEDGFp75, implicated in cancer, HIV-AIDS, and inflammation. While their frequency has been investigated in various ethnic populations, there is little information on their frequency among Hispanics/Latinos. Read More

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http://dx.doi.org/10.1007/s13317-016-0089-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125105PMC
December 2017
76 Reads

Development and evaluation of a standardized ELISA for the determination of autoantibodies against cN-1A (Mup44, NT5C1A) in sporadic inclusion body myositis.

Auto Immun Highlights 2016 Dec 17;7(1):16. Epub 2016 Nov 17.

Institute for Experimental Immunology, Euroimmun AG, Seekamp 31, 23560, Lübeck, Germany.

Purpose: Sporadic inclusion body myositis (sIBM) is an autoimmune degenerative disease of the muscle, with inflammatory infiltrates and inclusion vacuoles. Its pathogenesis is not fully understood and the diagnosis is hampered by its imprecise characteristics, at times indistinguishable from other idiopathic inflammatory myopathies such as polymyositis and dermatomyositis. The diagnosis may be assisted by the detection of autoantibodies targeting Mup44, a skeletal muscle antigen identified as cytosolic 5'-nucleotidase 1A (cN-1A, NT5C1A). Read More

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http://dx.doi.org/10.1007/s13317-016-0088-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114199PMC
December 2016
122 Reads

Anti-rods/rings autoantibody seropositivity does not affect response to telaprevir treatment for chronic hepatitis C infection.

Auto Immun Highlights 2016 Dec 14;7(1):15. Epub 2016 Nov 14.

Department of Oral Biology, University of Florida, 1395 Center Drive, Gainesville, FL, 32610-0424, USA.

Purpose: Autoantibodies to intracellular 'rods and rings' structures (anti-rods/rings or anti-RR) are strongly associated with hepatitis C (HCV) patients treated with interferon-α/ribavirin (IFN/RBV) and are linked with non-responsiveness to IFN/RBV or relapse, especially in Italian patients. This is the first study to determine whether there is any correlation of anti-RR with non-responsiveness to IFN/RBV treatment in patients also treated with telaprevir (TPV), one of several new therapies for chronic HCV recently implemented.

Methods: From 2013 to 2014, 52 HCV-infected patients were treated with IFN/RBV and TPV at five Italian clinics. Read More

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http://dx.doi.org/10.1007/s13317-016-0087-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108729PMC
December 2016
23 Reads

Intraepithelial lymphocytes subsets in different forms of celiac disease.

Auto Immun Highlights 2016 Dec 23;7(1):14. Epub 2016 Sep 23.

Immunology Section, Hospital Universitario Marqués de Valdecilla-IDIVAL, 39008, Santander, Spain.

Aim: The enumeration of intraepithelial lymphocytes subsets (total, γδ, and CD3(-) IELs) by flow cytometry (FCM), named as IEL lymphogram, constitutes a useful tool for celiac disease (CD) diagnosis. The aim of this study was to quantify IELs by FCM and their diagnostic value to differentiate active, silent and potential CD.

Methods: Prospective study of 60 active and 20 silent CD patients, and 161 controls in which duodenal biopsy and IEL quantification by FCM was performed. Read More

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http://dx.doi.org/10.1007/s13317-016-0085-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035275PMC
December 2016
9 Reads

Infections as a cause of autoimmune rheumatic diseases.

Auto Immun Highlights 2016 Dec 14;7(1):13. Epub 2016 Sep 14.

Department of Rheumatology and Clinical Immunology, University of Thessaly Medical School, Biopolis, 40 500, Larissa, Greece.

Exogenous and endogenous environmental exposures and particularly infections may participate in the breakage of tolerance and the induction of autoimmunity in rheumatic diseases. Response to infections apparently occurs years before clinical manifestations and features of autoimmunity, such as autoantibodies, are detected years before clinical manifestations in autoimmune rheumatic diseases. In this review, we summarize the current evidence for a potential causal link between infectious agents and rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, Sjogren's syndrome and ANCA-associated vasculitis. Read More

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http://dx.doi.org/10.1007/s13317-016-0086-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023637PMC
December 2016
32 Reads

Deciphering the role of DNA methylation in multiple sclerosis: emerging issues.

Auto Immun Highlights 2016 Dec 7;7(1):12. Epub 2016 Sep 7.

Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, University Hospital of Larissa, Larissa, Greece.

Multiple sclerosis (MS) is an autoimmune inflammatory and neurodegenerative disease of the central nervous system that involves several not yet fully elucidated pathophysiologic mechanisms. There is increasing evidence that epigenetic modifications at level of DNA bases, histones, and micro-RNAs may confer risk for MS. DNA methylation seems to have a prominent role in the epigenetics of MS, as aberrant methylation in the promoter regions across genome may underlie several processes involved in the initiation and development of MS. Read More

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http://dx.doi.org/10.1007/s13317-016-0084-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014764PMC
December 2016
52 Reads

Reactive oxygen species in organ-specific autoimmunity.

Auto Immun Highlights 2016 Dec 4;7(1):11. Epub 2016 Aug 4.

Division of Immunology, Department of Pathology, The Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.

Reactive oxygen species (ROS) have been extensively studied in the induction of inflammation and tissue damage, especially as it relates to aging. In more recent years, ROS have been implicated in the pathogenesis of autoimmune diseases. Here, ROS accumulation leads to apoptosis and autoantigen structural changes that result in novel specificities. Read More

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http://dx.doi.org/10.1007/s13317-016-0083-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974204PMC
December 2016
36 Reads

Measurement of anti-DFS70 antibodies in patients with ANA-associated autoimmune rheumatic diseases suspicion is cost-effective.

Auto Immun Highlights 2016 Dec 29;7(1):10. Epub 2016 Jul 29.

Hospital Universitario Marqués de Valdecilla-IDIVAL, Santander, Spain.

The presence of antinuclear antibodies (ANA) is associated with a wide range of ANA-associated autoimmune rheumatic diseases (AARD). The most commonly method used for the detection of ANA is indirect immunofluorescence (IIF) on HEp-2 cells. This method is very sensitive but unspecific. Read More

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http://dx.doi.org/10.1007/s13317-016-0082-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967047PMC
December 2016
130 Reads