108 results match your criteria Auto- immunity highlights[Journal]


Association of HLA-B27 and Behcet's disease: a systematic review and meta-analysis.

Auto Immun Highlights 2019 Mar 19;10(1). Epub 2019 Mar 19.

Tabriz Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: To calculate the genetic impact of the "HLA-B27" allele on the risk of Behcet's disease (BD) progression using a systematic review and meta-analysis on case control papers.

Methods: A systematic review search was conducted on the MeSH keywords of Behcet's disease, HLAB27 and B27 in PubMed, Scopus, ProQuest, EMBASE, SID, Magiran, IranDoc and IranMedex databases from 1975 to Aug 2017. Data underwent meta-analysis (random effect model) in CMA2 software. Read More

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http://dx.doi.org/10.1186/s13317-019-0112-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424999PMC

Protective effect of TSLP and IL-33 cytokines in ulcerative colitis.

Auto Immun Highlights 2019 Mar 14;10(1). Epub 2019 Mar 14.

Gut and Liver Research Center, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran.

Purpose: Inflammatory bowel disease (IBD) primarily includes ulcerative colitis (UC) and Crohn's disease (CD). Thymic stromal lymphopoietin (TSLP) is a cytokine produced by intestinal epithelial cells (IECs) with immunomodulatory properties that plays an important role in the development of regulatory T cell (Treg) responses and tolerance in the gut. On the other hand, IL-33 has been considered as a cytokine with two different properties, inflammatory and anti-inflammatory functions, the latter may play a protective role against chronic intestinal inflammation. Read More

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http://dx.doi.org/10.1186/s13317-019-0110-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416230PMC
March 2019
1 Read

Regulatory B and T lymphocytes in multiple sclerosis: friends or foes?

Auto Immun Highlights 2018 Nov 10;9(1). Epub 2018 Nov 10.

Department of Neurology and Laboratory of Neurogenetics, Faculty of Medicine, School of Health Sciences, University General Hospital of Larissa, University of Thessaly, Biopolis, 40500, Larissa, Greece.

Current clinical experience with immunomodulatory agents and monoclonal antibodies in principle has established the benefit of depleting lymphocytic populations in relapsing-remitting multiple sclerosis (RRMS). B and T cells may exert multiple pro-inflammatory actions, but also possess regulatory functions making their role in RRMS pathogenesis much more complex. There is no clear correlation of Tregs and Bregs with clinical features of the disease. Read More

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http://link.springer.com/10.1007/s13317-018-0109-x
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http://dx.doi.org/10.1007/s13317-018-0109-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230324PMC
November 2018
29 Reads

Performance analysis of automated evaluation of antinuclear antibody indirect immunofluorescent tests in a routine setting.

Auto Immun Highlights 2018 Sep 21;9(1). Epub 2018 Sep 21.

Central Diagnostic Laboratory, Maastricht University Medical Center, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands.

Purpose: Indirect immunofluorescence (IIF) on the human epithelial cell-line HEp-2 (or derivatives) serves as the gold standard in antinuclear antibody (ANA) screening. IIF, and its evaluation, is a labor-intensive method, making ANA testing a major challenge for present clinical laboratories. Nowadays, several automated ANA pattern recognition systems are on the market. Read More

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http://link.springer.com/10.1007/s13317-018-0108-y
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http://dx.doi.org/10.1007/s13317-018-0108-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147779PMC
September 2018
9 Reads

Remission of aggressive autoimmune disease (dermatomyositis) with removal of infective jaw pathology and ozone therapy: review and case report.

Authors:
Robert Jay Rowen

Auto Immun Highlights 2018 Jun 30;9(1). Epub 2018 Jun 30.

Private Medical Practice, 2200 County Center Dr. Ste C, Santa Rosa, CA, 95403, USA.

Introduction: This case uniquely reports a connection between endodontically infected teeth and systemic disease, and additionally presents ozone therapy as a unique therapy and immune system modulator. It is the world's first such reported case and the treatment holds invaluable lessons in assessing the "unknown" causes of autoimmunity and inflammation. Additionally, it presents ozone therapy as a most needed unique, non-toxic and powerful anti-infective agent, anti-inflammatory and immune modulator. Read More

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http://dx.doi.org/10.1007/s13317-018-0107-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026108PMC
June 2018
12 Reads

Anti-phospholipid IgG antibodies detected by line immunoassay differentiate patients with anti-phospholipid syndrome and other autoimmune diseases.

Auto Immun Highlights 2018 May 29;9(1). Epub 2018 May 29.

University of Brescia, Brescia, Italy.

Purpose: Anti-phospholipid antibodies (aPL) analyzed by line immunoassay (LIA) can recognize beta-glycoprotein I (βGPI) domain 1 (D1) epitopes depending on βGPI binding to distinct phospholipids. The aPL LIA was compared with consensus ELISA to investigate whether both techniques can discriminate anti-phospholipid syndrome (APS) patients from aPL-positive, systemic autoimmune rheumatic diseases (SARD) patients without clinical symptoms of APS and controls.

Methods: Thirty-four APS patients (14 arterial/venous thrombosis, 16 pregnancy morbidity, and 4 both), 41 patients with SARD lacking clinical APS criteria but demonstrating positivity for anti-βGPI (aβGPI) IgG, and 20 healthy subjects (HS) were tested for aPL to cardiolipin (aCL), phosphatidic acid, phosphatidylcholine, phosphatidylethanolamine, phosphatidylglycerol (aPG), phosphatidylinositol, phosphatidylserine, βGPI, prothrombin, and annexin V by LIA. Read More

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http://link.springer.com/10.1007/s13317-018-0106-0
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http://dx.doi.org/10.1007/s13317-018-0106-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975024PMC
May 2018
15 Reads

Rhabdomyolysis secondary to systemic lupus erythematosus.

Auto Immun Highlights 2018 Apr 6;9(1). Epub 2018 Apr 6.

Texas Tech University Health Sciences Center Amarillo School of Medicine, 1400 S Coulter St, Amarillo, TX, 79106, USA.

Systemic lupus erythematous (SLE) is a systemic auto-immune disorder with a variety of presentations and wide spread organ involvement. We present a case report of a patient with an SLE exacerbation as well as concurrent rhabdomyolysis with massively elevated CPK (304,700 U/L). Though a rarely reported effect of SLE, rhabdomyolysis can be severe and potentially lethal secondary or concurrent to an acute SLE episode. Read More

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http://link.springer.com/10.1007/s13317-018-0105-1
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http://dx.doi.org/10.1007/s13317-018-0105-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886906PMC
April 2018
28 Reads

Isolated acute lupus pneumonitis as the initial presentation of systemic lupus erythematosus in an 8-year-old girl.

Auto Immun Highlights 2018 Mar 27;9(1). Epub 2018 Mar 27.

Department of Radiology, Faculty of Medicine, Gazi University, Ankara, Turkey.

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease which has broad pleuropulmonary manifestations. One of the rare and mortal complications is acute lupus pneumonitis, which is reported very rarely, especially in childhood. Herein, we report an 8-year-old girl with isolated acute lupus pneumonitis as the initial presentation that required a lung biopsy for diagnosis. Read More

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http://dx.doi.org/10.1007/s13317-018-0104-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869323PMC
March 2018
13 Reads

Diagnostic accuracy of a new fluoroenzyme immunoassay for the detection of TSH receptor autoantibodies in Graves' disease.

Auto Immun Highlights 2018 Feb 12;9(1). Epub 2018 Feb 12.

Clinical Pathology Laboratory, S. Maria degli Angeli Hospital, Pordenone, Italy.

Purpose: Thyrotropin receptor (TSHR) autoantibodies (TRAbs) are a hallmark of Graves' disease (GD). The aim of this study was to evaluate the diagnostic accuracy of a new third generation automatic fluorescence enzyme immunoassay for TRAb measurement in GD, in comparison with two current IMAs.

Methods: Sera of 439 subjects (57 patients with untreated GD, 34 with treated GD, 15 with GD and Graves' orbitopathy, 52 with multinodular non-toxic goiter, 86 with Hashimoto's thyroiditis, 20 with toxic adenoma or toxic multinodular goiter, 55 with non-thyroid autoimmune diseases and 120 normal controls) were tested for TRAbs with the ELiA anti-TSH-R assay (ThermoFischer Scientific, Uppsala, Sweden), the TRAK RIA, Brahms (Thermo Scientific, Hennigsdorf, Germany) and the Immulite TSI assay (Siemens Healthcare, Llanberis, UK). Read More

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http://dx.doi.org/10.1007/s13317-018-0102-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809681PMC
February 2018
12 Reads

Platelet-activating factor acetylhydrolase in primary antiphospholipid syndrome.

Auto Immun Highlights 2018 Feb 10;9(1). Epub 2018 Feb 10.

Department of Cell Chemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Neutron Therapy Research Center and Collaborative Research Center for OMIC, Okayama University, Okayama, Japan.

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http://dx.doi.org/10.1007/s13317-018-0103-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812120PMC
February 2018
10 Reads

Role of vitamin D deficiency in systemic lupus erythematosus incidence and aggravation.

Auto Immun Highlights 2017 Dec 26;9(1). Epub 2017 Dec 26.

Talented Student Center, Student Research Committee, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, I.R., Iran.

Vitamin D is one of the main groups of sterols; playing an important role in phospho-calcic metabolism. The conversion of 7-dehydrocholesterol to pre- vitamin D3 in the skin, through solar ultraviolet B radiation, is the main source of vitamin D. Since lupus patients are usually photosensitive, the risk of developing vitamin D deficiency in is high in this population. Read More

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http://dx.doi.org/10.1007/s13317-017-0101-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743852PMC
December 2017
5 Reads
1 Citation

HLA-DQ2 and -DQ8 haplotypes frequency and diagnostic utility in celiac disease patients of Gaza strip, Palestine.

Auto Immun Highlights 2017 Nov 15;8(1):11. Epub 2017 Nov 15.

Faculty of Medicine, The Islamic University of Gaza, Gaza, Palestine.

Purpose: Celiac disease (CD) diagnosis can be established by serological and small bowel biopsy (SBB), while absence of HLA-DQ2 and -DQ8 haplotypes excludes the disease. The present study aims at evaluating the diagnosis of a representative sample of pediatric and adult CD patients of Gaza strip in light of DQ2 and DQ8 haplotypes expression.

Methods: Unrelated CD patients (n = 101) and matched healthy controls (n = 97) were genotyped for DQA1*05, DQB1*02 and DQB1*03:02 alleles by allele-specific real-time PCR. Read More

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http://dx.doi.org/10.1007/s13317-017-0099-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688040PMC
November 2017
4 Reads

Next-generation anti-CD20 monoclonal antibodies in autoimmune disease treatment.

Auto Immun Highlights 2017 Nov 16;8(1):12. Epub 2017 Nov 16.

Graduate Program in Immunology, Program in Biomedical Sciences, University of Michigan Medical School, Ann Arbor, USA.

The clinical success of anti-CD20 monoclonal antibody (mAb)-mediated B cell depletion therapy has contributed to the understanding of B cells as major players in several autoimmune diseases. The first therapeutic anti-CD20 mAb, rituximab, is a murine-human chimera to which many patients develop antibodies and/or experience infusion-related reactions. A second generation of anti-CD20 mAbs has been designed to be more effective, better tolerated, and of lower immunogenicity. Read More

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http://dx.doi.org/10.1007/s13317-017-0100-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688039PMC
November 2017
5 Reads

Personalized medicine in rheumatology: the paradigm of serum autoantibodies.

Auto Immun Highlights 2017 Dec 12;8(1):10. Epub 2017 Jul 12.

Division of Rheumatology and Clinical Immunology, Humanitas Research Hospital, Via A. Manzoni 56, Rozzano, 20089, Milan, Italy.

The sequencing of the human genome is now well recognized as the starting point of personalized medicine. Nonetheless, everyone is unique and can develop different phenotypes of the same disease, despite identical genotypes, as well illustrated by discordant monozygotic twins. To recognize these differences, one of the easiest and most familiar examples of biomarkers capable of identifying and predicting the outcome of patients is represented by serum autoantibodies. Read More

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http://dx.doi.org/10.1007/s13317-017-0098-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507804PMC
December 2017
5 Reads

Chemiluminescent immunoassay technology: what does it change in autoantibody detection?

Auto Immun Highlights 2017 Dec 24;8(1). Epub 2017 Jun 24.

Laboratorio di Patologia Clinica, Ospedale San Antonio, Azienda Sanitaria Universitaria Integrata di Udine, Tolmezzo, Italy.

Diagnostic technology is rapidly evolving, and over the last decade, substantial progress has been made even for the identification of antibodies, increasingly approaching this type of diagnostic to that of automated clinical chemistry laboratory. In this review, we describe the analytical and diagnostic characteristics of chemiluminescence technology in its strength and in its applicability for a more rapid and accurate diagnosis of autoimmune diseases. The wide dynamic range, greater than that of immunoenzymatic methods, the high sensitivity and specificity of the results expressed in quantitative form, the high degree of automation and the clinical implications related to the reduction in the turnaround time, and the ability to run a large number of antibody tests (even of different isotypes), directed towards large antigenic panels in random access mode, make this technology the most advanced in the clinical laboratory, with enormous repercussions on the workflow and on the autoimmunology laboratory organisation. Read More

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http://dx.doi.org/10.1007/s13317-017-0097-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483212PMC
December 2017
2 Reads

Definition of the upper reference limit for thyroglobulin antibodies according to the National Academy of Clinical Biochemistry guidelines: comparison of eleven different automated methods.

Auto Immun Highlights 2017 Dec 19;8(1). Epub 2017 Jun 19.

Clinical Pathology Laboratory, 'S. Maria degli Angeli' Hospital, Pordenone, Italy.

Purpose: In the last two decades, thyroglobulin autoantibodies (TgAb) measurement has progressively switched from marker of thyroid autoimmunity to test associated with thyroglobulin (Tg) to verify the presence or absence of TgAb interference in the follow-up of patients with differentiated thyroid cancer. Of note, TgAb measurement is cumbersome: despite standardization against the International Reference Preparation MRC 65/93, several studies demonstrated high inter-method variability and wide variation in limits of detection and in reference intervals. Taking into account the above considerations, the main aim of the present study was the determination of TgAb upper reference limit (URL), according to the National Academy of Clinical Biochemistry guidelines, through the comparison of eleven commercial automated immunoassay platforms. Read More

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http://dx.doi.org/10.1007/s13317-017-0096-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476530PMC
December 2017
3 Reads

Induction of IL-10 cytokine and the suppression of T cell proliferation by specific peptides from red cell band 3 and in vivo effects of these peptides on autoimmune hemolytic anemia in NZB mice.

Auto Immun Highlights 2017 Dec 28;8(1). Epub 2017 Apr 28.

School of Cellular and Molecular Medicine, University of Bristol, Biomedical Sciences Building, Bristol, BS8 1TD, UK.

Purpose: The anion channel protein band 3 is the main target of the pathogenic red blood cells (RBC) autoantibodies in New Zealand black (NZB) mice. CD4 T cells from NZB mice with autoimmune hemolytic anemia respond to band 3. Previously, we have shown that IL-10 and peptides containing a dominant T cell epitope from red cell band 3 modulate autoimmune hemolytic anemia in NZB mice. Read More

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http://dx.doi.org/10.1007/s13317-017-0095-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408328PMC
December 2017
1 Read

A case of sarcoidosis with isolated hepatosplenic onset and development of inflammatory bowel disease during recovery stage.

Auto Immun Highlights 2017 Dec 28;8(1). Epub 2017 Apr 28.

Clinica Medica "Cesare Frugoni", Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", Piazza Giulio Cesare 11, 70124, Bari, Italy.

Sarcoidosis is a systemic disease characterized by an immune-mediated disorder, which leads to the development of non-caseating granulomas in the involved organs. More than 90% of patients with sarcoidosis present lungs and lymphatic system involvement at onset, while less than 10% has an isolated extrapulmonary localization. Here, we describe the case of an elderly patient with isolated hepato-splenic onset (multiple splenic lesions at imaging and cholestasis), and subsequent pulmonary involvement. Read More

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http://dx.doi.org/10.1007/s13317-017-0094-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408327PMC
December 2017
6 Reads

Exploring the plasmatic platelet-activating factor acetylhydrolase activity in patients with anti-phospholipid antibodies.

Auto Immun Highlights 2017 Dec 25;8(1). Epub 2017 Mar 25.

Department of Medical and Biological Sciences, University of Udine, Padiglione CSL - Via Chiusaforte, Ingresso F3, 33100, Udine, Italy.

Purpose: To explore the role of plasmatic platelet-activating factor acetylhydrolase (PAF-AH), a marker of cardiovascular risk, in patients with anti-phospholipid antibodies (aPL).

Methods: PAF-AH activity was assessed in a series of 167 unselected patients screened for aPL in a context of thrombotic events, risk of thrombosis or obstetric complications and in 77 blood donors.

Results: 116/167 patients showed positive results for at least one aPL among IgG/IgM anti-prothrombin/phosphatidylserine (aPS/PT), anti-cardiolipin (aCL), anti-beta2-glycoprotein I (aβ2GPI) or lupus anticoagulant (LAC), while 51/167 patients resulted aPL-negative. Read More

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http://dx.doi.org/10.1007/s13317-017-0092-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365449PMC
December 2017
3 Reads

The universe of ANA testing: a case for point-of-care ANA testing.

Auto Immun Highlights 2017 Dec 21;8(1). Epub 2017 Mar 21.

Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 1 University of New Mexico, Albuquerque, NM, 87131, USA.

Testing for total antinuclear antibodies (ANA) is a critical tool for diagnosis and management of autoimmune diseases at both the primary care and subspecialty settings. Repurposing of ANA from a test for lupus to a test for any autoimmune condition has driven the increase in ANA requests. Changes in ANA referral patterns include early or subclinical autoimmune disease detection in patients with low pre-test probability and use of negative ANA results to rule out underlying autoimmune disease. Read More

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http://dx.doi.org/10.1007/s13317-017-0093-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360668PMC
December 2017
8 Reads

Analysis of DFS70 pattern and impact on ANA screening using a novel HEp-2 ELITE/DFS70 knockout substrate.

Auto Immun Highlights 2017 Dec 17;8(1). Epub 2017 Mar 17.

Immco Diagnostics, A Trinity Biotech Company, 60 Pineview Drive, Buffalo, New York, 14228, USA.

Indirect immunofluorescence (IIF) using human epithelial cell (HEp-2) substrate is a widely used and the recommended method for screening of antinuclear antibodies (ANA). Dense fine speckled (DFS70) pattern on HEp-2 has been widely reported in various healthy and disease groups. Interpretation of DFS70 pattern can be challenging on a conventional HEp-2 substrate due to its similarity to some of the disease associated patterns. Read More

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http://dx.doi.org/10.1007/s13317-017-0091-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357240PMC
December 2017

Structure and activation of the TSH receptor transmembrane domain.

Auto Immun Highlights 2017 Dec 5;8(1). Epub 2016 Dec 5.

FIRS Laboratories, RSR Ltd, Parc Ty Glas, Llanishen, Cardiff, CF14 5DU, UK.

Purpose: The thyroid-stimulating hormone receptor (TSHR) is the target autoantigen for TSHR-stimulating autoantibodies in Graves' disease. The TSHR is composed of: a leucine-rich repeat domain (LRD), a hinge region or cleavage domain (CD) and a transmembrane domain (TMD). The binding arrangements between the TSHR LRD and the thyroid-stimulating autoantibody M22 or TSH have become available from the crystal structure of the TSHR LRD-M22 complex and a comparative model of the TSHR LRD in complex with TSH, respectively. Read More

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http://dx.doi.org/10.1007/s13317-016-0090-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136658PMC
December 2017
42 Reads

Detection of autoantibodies to DSF70/LEDGFp75 in Mexican Hispanics using multiple complementary assay platforms.

Auto Immun Highlights 2017 Dec 24;8(1). Epub 2016 Nov 24.

Department of Basic Sciences, Center for Health Disparities and Molecular Medicine, Loma Linda University School of Medicine, Mortensen Hall 142, 11085 Campus St., Loma Linda, CA, 92350, USA.

Purpose: Antinuclear autoantibodies (ANA) targeting the dense fine speckled antigen DFS70, also known as lens epithelium-derived growth factor p75 (LEDGF/p75), are attracting attention due to their low frequency in systemic rheumatic diseases but increased frequency in clinical laboratory referrals and healthy individuals (HI). These ANA specifically recognize the stress protein DFS70/LEDGFp75, implicated in cancer, HIV-AIDS, and inflammation. While their frequency has been investigated in various ethnic populations, there is little information on their frequency among Hispanics/Latinos. Read More

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http://dx.doi.org/10.1007/s13317-016-0089-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125105PMC
December 2017
46 Reads

Development and evaluation of a standardized ELISA for the determination of autoantibodies against cN-1A (Mup44, NT5C1A) in sporadic inclusion body myositis.

Auto Immun Highlights 2016 Dec 17;7(1):16. Epub 2016 Nov 17.

Institute for Experimental Immunology, Euroimmun AG, Seekamp 31, 23560, Lübeck, Germany.

Purpose: Sporadic inclusion body myositis (sIBM) is an autoimmune degenerative disease of the muscle, with inflammatory infiltrates and inclusion vacuoles. Its pathogenesis is not fully understood and the diagnosis is hampered by its imprecise characteristics, at times indistinguishable from other idiopathic inflammatory myopathies such as polymyositis and dermatomyositis. The diagnosis may be assisted by the detection of autoantibodies targeting Mup44, a skeletal muscle antigen identified as cytosolic 5'-nucleotidase 1A (cN-1A, NT5C1A). Read More

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http://dx.doi.org/10.1007/s13317-016-0088-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114199PMC
December 2016
55 Reads

Anti-rods/rings autoantibody seropositivity does not affect response to telaprevir treatment for chronic hepatitis C infection.

Auto Immun Highlights 2016 Dec 14;7(1):15. Epub 2016 Nov 14.

Department of Oral Biology, University of Florida, 1395 Center Drive, Gainesville, FL, 32610-0424, USA.

Purpose: Autoantibodies to intracellular 'rods and rings' structures (anti-rods/rings or anti-RR) are strongly associated with hepatitis C (HCV) patients treated with interferon-α/ribavirin (IFN/RBV) and are linked with non-responsiveness to IFN/RBV or relapse, especially in Italian patients. This is the first study to determine whether there is any correlation of anti-RR with non-responsiveness to IFN/RBV treatment in patients also treated with telaprevir (TPV), one of several new therapies for chronic HCV recently implemented.

Methods: From 2013 to 2014, 52 HCV-infected patients were treated with IFN/RBV and TPV at five Italian clinics. Read More

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http://dx.doi.org/10.1007/s13317-016-0087-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108729PMC
December 2016
20 Reads

Intraepithelial lymphocytes subsets in different forms of celiac disease.

Auto Immun Highlights 2016 Dec 23;7(1):14. Epub 2016 Sep 23.

Immunology Section, Hospital Universitario Marqués de Valdecilla-IDIVAL, 39008, Santander, Spain.

Aim: The enumeration of intraepithelial lymphocytes subsets (total, γδ, and CD3(-) IELs) by flow cytometry (FCM), named as IEL lymphogram, constitutes a useful tool for celiac disease (CD) diagnosis. The aim of this study was to quantify IELs by FCM and their diagnostic value to differentiate active, silent and potential CD.

Methods: Prospective study of 60 active and 20 silent CD patients, and 161 controls in which duodenal biopsy and IEL quantification by FCM was performed. Read More

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http://dx.doi.org/10.1007/s13317-016-0085-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035275PMC
December 2016
5 Reads

Infections as a cause of autoimmune rheumatic diseases.

Auto Immun Highlights 2016 Dec 14;7(1):13. Epub 2016 Sep 14.

Department of Rheumatology and Clinical Immunology, University of Thessaly Medical School, Biopolis, 40 500, Larissa, Greece.

Exogenous and endogenous environmental exposures and particularly infections may participate in the breakage of tolerance and the induction of autoimmunity in rheumatic diseases. Response to infections apparently occurs years before clinical manifestations and features of autoimmunity, such as autoantibodies, are detected years before clinical manifestations in autoimmune rheumatic diseases. In this review, we summarize the current evidence for a potential causal link between infectious agents and rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, Sjogren's syndrome and ANCA-associated vasculitis. Read More

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http://dx.doi.org/10.1007/s13317-016-0086-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023637PMC
December 2016
10 Reads

Deciphering the role of DNA methylation in multiple sclerosis: emerging issues.

Auto Immun Highlights 2016 Dec 7;7(1):12. Epub 2016 Sep 7.

Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, University Hospital of Larissa, Larissa, Greece.

Multiple sclerosis (MS) is an autoimmune inflammatory and neurodegenerative disease of the central nervous system that involves several not yet fully elucidated pathophysiologic mechanisms. There is increasing evidence that epigenetic modifications at level of DNA bases, histones, and micro-RNAs may confer risk for MS. DNA methylation seems to have a prominent role in the epigenetics of MS, as aberrant methylation in the promoter regions across genome may underlie several processes involved in the initiation and development of MS. Read More

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http://dx.doi.org/10.1007/s13317-016-0084-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014764PMC
December 2016
28 Reads

Reactive oxygen species in organ-specific autoimmunity.

Auto Immun Highlights 2016 Dec 4;7(1):11. Epub 2016 Aug 4.

Division of Immunology, Department of Pathology, The Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.

Reactive oxygen species (ROS) have been extensively studied in the induction of inflammation and tissue damage, especially as it relates to aging. In more recent years, ROS have been implicated in the pathogenesis of autoimmune diseases. Here, ROS accumulation leads to apoptosis and autoantigen structural changes that result in novel specificities. Read More

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http://dx.doi.org/10.1007/s13317-016-0083-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974204PMC
December 2016
18 Reads

Measurement of anti-DFS70 antibodies in patients with ANA-associated autoimmune rheumatic diseases suspicion is cost-effective.

Auto Immun Highlights 2016 Dec 29;7(1):10. Epub 2016 Jul 29.

Hospital Universitario Marqués de Valdecilla-IDIVAL, Santander, Spain.

The presence of antinuclear antibodies (ANA) is associated with a wide range of ANA-associated autoimmune rheumatic diseases (AARD). The most commonly method used for the detection of ANA is indirect immunofluorescence (IIF) on HEp-2 cells. This method is very sensitive but unspecific. Read More

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http://dx.doi.org/10.1007/s13317-016-0082-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967047PMC
December 2016
87 Reads

The ANA-reflex test as a model for improving clinical appropriateness in autoimmune diagnostics.

Auto Immun Highlights 2016 Dec 16;7(1). Epub 2016 Jul 16.

DIMI, University of Genova, Genoa, Italy.

Reflex tests are widely used in clinical laboratories, for example, to diagnose thyroid disorders or in the follow-up of prostate cancer. Reflex tests for antinuclear antibodies (ANA) have recently gained attention as a way to improve appropriateness in the immunological diagnosis of autoimmune rheumatic diseases and avoid waste of resources. However, the ANA-reflex test is not as simple as other consolidated reflex tests (the TSH-reflex tests or the PSA-reflex tests) because of the intrinsic complexity of the ANA test performed by the indirect immunofluorescence method on cellular substrates. Read More

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http://dx.doi.org/10.1007/s13317-016-0080-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947463PMC
December 2016
21 Reads

Recognition of the dense fine speckled (DFS) pattern remains challenging: results from an international internet-based survey.

Auto Immun Highlights 2016 Dec 9;7(1). Epub 2016 Jul 9.

Department of Research and Development, Inova Diagnostics, 9900 Old Grove Road, San Diego, CA, 92131-1638, USA.

Purpose: The dense fine speckled (DFS) pattern as detected by indirect immunofluorescence (IIF) on HEp-2 cells has been associated with several inflammatory diseases but is most commonly observed in individuals that do not have an antinuclear antibody (ANA)-associated rheumatic disease and even in apparently healthy individuals. Consequently, the accurate identification and correct reporting of this IIF pattern is of utmost importance and accordingly has been recognized by several international study groups for the detection of ANA. Furthermore, the DFS IIF pattern has recently been recommended as a competency level recognition pattern by the International Consensus on Antinuclear Antibody (ANA) Pattern (ICAP, http://www. Read More

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http://dx.doi.org/10.1007/s13317-016-0081-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939145PMC
December 2016
19 Reads

An unusual association of three autoimmune disorders: celiac disease, systemic lupus erythematosus and Hashimoto's thyroiditis.

Auto Immun Highlights 2016 Dec 6;7(1). Epub 2016 Jul 6.

Department of Interdisciplinary Medicine, University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70124, Bari, Italy.

Autoimmune disorders are known to be more frequent in women and often associated each others, but it is rare to see multiple autoimmune diseases in a single patient. Recently, the concept of multiple autoimmune syndrome has been introduced to describe patients with at least three autoimmune diseases. We describe a case of a young man with a clinical history of psychiatric symptoms and celiac disease (CD) who was diagnosed to have other two autoimmune disorders: systemic lupus erythematosus (SLE) and Hashimoto's thyroiditis. Read More

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http://dx.doi.org/10.1007/s13317-016-0079-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935668PMC
December 2016
3 Reads

The relative merits of therapies being developed to tackle inappropriate ('self'-directed) complement activation.

Auto Immun Highlights 2016 Dec 3;7(1). Epub 2016 Mar 3.

Department of Medical Laboratory Sciences, School of Allied Health Sciences, College of Health Sciences, University of Ghana, P. O. Box KB 143, Korle-Bu, Accra, Ghana.

The complement system is an enzyme cascade that helps defend against infection. Many complement proteins occur in serum as inactive enzyme precursors or reside on cell surfaces. Complement components have many biologic functions and their activation can eventually damage the plasma membranes of cells and some bacteria. Read More

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http://dx.doi.org/10.1007/s13317-016-0078-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775539PMC
December 2016
9 Reads

Nailfold videocapillaroscopy and serum VEGF levels in scleroderma are associated with internal organ involvement.

Auto Immun Highlights 2016 Dec 15;7(1). Epub 2016 Feb 15.

Rheumatology and Clinical Immunology, Humanitas Research Hospital, Rozzano, Milan, Italy.

Purpose: Nailfold videocapillaroscopy (NVC) identifies the microvascular hallmarks of systemic sclerosis (SSc) and vascular endothelial growth factor (VEGF) and may play a pivotal role in the associated vasculopathy. The aim of the present study was to compare NVC alterations with clinical subsets, internal organ involvement, and serum VEGF levels in a cohort of selected SSc cases.

Methods: We studied 44 patients with SSc who were evaluated within 3 months from enrollment by NVC, skin score, severity index, pulmonary function tests, carbon monoxide diffusing capacity (DLCO), echocardiography, pulmonary high-resolution computed tomography (HRCT), gastroesophageal (GE) endoscopy or manometry or X-ray, and serum autoantibodies. Read More

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http://dx.doi.org/10.1007/s13317-016-0077-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754208PMC
December 2016
19 Reads

Behçet's disease physiopathology: a contemporary review.

Auto Immun Highlights 2016 Dec 12;7(1). Epub 2016 Feb 12.

Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Sorbonne Universités, UPMC Univ Paris 06, UMR 7211, 75005, Paris, France.

Behçet's disease, also known as the Silk Road Disease, is a rare systemic vasculitis disorder of unknown etiology. Recurrent attacks of acute inflammation characterize Behçet's disease. Frequent oral aphthous ulcers, genital ulcers, skin lesions and ocular lesions are the most common manifestations. Read More

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http://dx.doi.org/10.1007/s13317-016-0074-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751097PMC
December 2016
25 Reads

Disease prevalence in a rural Andean population of central Peru: a focus on autoimmune and allergic diseases.

Auto Immun Highlights 2016 Dec 10;7(1). Epub 2016 Feb 10.

Department of Pathology, School of Medicine, The Johns Hopkins University, Baltimore, MD, USA.

Introduction: The hygiene hypothesis, formulated to explain the increased incidence of allergic and autoimmune diseases observed in industrialized countries, remains controversial. We reflected upon this hypothesis during a medical mission to rural and impoverished villages of central Peru.

Materials And Methods: The mission was carried out in July 2015 to aid three Andean villages located near Cusco, and comprised 10 American physicians, 4 nurses, and 24 students. Read More

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http://dx.doi.org/10.1007/s13317-016-0076-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749512PMC
December 2016
1 Read

Simultaneous detection of celiac disease-specific IgA antibodies and total IgA.

Auto Immun Highlights 2016 Dec 30;7(1). Epub 2016 Jan 30.

GA Generic Assays GmbH, Dahlewitz, Germany.

Purpose: Celiac disease (CD) serology requires analysis of tissue transglutaminase type-2 (TG2autoAbs), deamidated gliadin (DGAbs), and as reference endomysial autoantibodies (EmA). Total IgA assessment helps to determine IgA-deficient CD patients. The novel multiplex indirect immunofluorescence (IIF) technique CytoBead was used to develop the first quantitative one-step serological CD assay comprising both simultaneous IgA autoAb and total IgA testing. Read More

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http://dx.doi.org/10.1007/s13317-016-0073-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733812PMC
December 2016
20 Reads

International consensus on ANA patterns (ICAP): the bumpy road towards a consensus on reporting ANA results.

Auto Immun Highlights 2016 Dec 30;7(1). Epub 2016 Jan 30.

Institute of Immunology, Technical University of Dresden, Dresden, Germany.

The International Consensus on ANA Patterns (ICAP) was initiated as a workshop aiming to thoroughly discuss and achieve consensus regarding the morphological patterns observed in the indirect immunofluorescence assay on HEp-2 cells. One of the topics discussed at the second ICAP workshop, and addressed in this paper, was the harmonization of reporting ANA test results. This discussion centered on the issue if cytoplasmic and mitotic patterns should be reported as positive or negative. Read More

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http://dx.doi.org/10.1007/s13317-016-0075-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733811PMC
December 2016
127 Reads

Typical evanescent and atypical persistent polymorphic cutaneous rash in an adult Brazilian with Still's disease: a case report and review of the literature.

Auto Immun Highlights 2015 Dec 30;6(3):39-46. Epub 2015 Sep 30.

Department of Internal Medicine, Bridgeport Hospital, Yale-New Haven Health System, Bridgeport, CT, USA.

Adult onset Still's disease (AOSD) is a systemic auto-inflammatory condition of unknown etiology, characterized by high fever, an evanescent, salmon-pink maculopapular skin rash, arthralgia or arthritis and leukocytosis. AOSD can also present with atypical cutaneous manifestations, such as persistent pruritic coalescent papules or plaques and linear lesions that have highly distinctive pathological features and are usually associated with severe disease. Herein, we present a 31-year-old Brazilian man with both typical Still's rash and atypical persistent polymorphic cutaneous manifestations associated with severe systemic inflammatory response syndrome. Read More

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http://dx.doi.org/10.1007/s13317-015-0071-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633415PMC
December 2015
6 Reads
3 Citations

Establishment of the upper reference limit for thyroid peroxidase autoantibodies according to the guidelines proposed by the National Academy of Clinical Biochemistry: comparison of five different automated methods.

Auto Immun Highlights 2015 Dec 15;6(3):31-7. Epub 2015 Aug 15.

Laboratory of Clinical Pathology, Department of Laboratory Medicine, S. Maria degli Angeli Hospital, Pordenone, Italy.

Aim Of The Study: The estimation of the upper reference limit (URL) for autoantibodies against thyroid peroxidase (TPOAbs) is a controversial issue, because of an uncertainty associated with the criteria used to correctly define the reference population. In addition, the URL of TPOAbs is method-dependent and often arbitrarily established in current laboratory practice. The aim of this study was to determine the reference limits of TPOAbs in a male sample according to the National Academy of Clinical Biochemistry (NACB) guidelines, and to compare them with those obtained in a female group, for five third-generation commercial-automated immunoassay (IMA) platforms. Read More

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http://dx.doi.org/10.1007/s13317-015-0070-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633414PMC
December 2015
34 Reads

IgG4-related disease: case report and literature review.

Auto Immun Highlights 2015 Aug 28;6(1-2):7-15. Epub 2015 Jul 28.

Division of Allergy and Clinical Immunology, Faculty of Medicine, Bnai Zion Medical Center, Technion-Israel Institute of Technology, Haifa, Israel.

IgG4-related disease (IgG4-RD) is relatively a new growing entity of immune-mediated origin, characterized by a mass-forming lesion, the infiltration of IgG4-positive plasma cells and occasionally elevated serum IgG4. It is considered to be both a systemic inflammation and sclerosing disease. The most common manifestations are parotid and lacrimal swelling, lymphadenopathy and autoimmune pancreatitis. Read More

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http://dx.doi.org/10.1007/s13317-015-0069-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536235PMC

Anti-zinc transporter protein 8 autoantibodies significantly improve the diagnostic approach to type 1 diabetes: an Italian multicentre study on paediatric patients.

Auto Immun Highlights 2015 Aug 21;6(1-2):17-22. Epub 2015 Jul 21.

Institute of Clinical Pathology, University Hospital of Udine, Piazzale S. Maria Misericordia 15, 33100, Udine, Italy,

Background And Aim: Anti-ZnT8 antibodies (ZnT8A) were recently proposed as a new independent serological marker in Type 1 diabetes (T1D), leading to a significant improvement of the positive predictive value of autoantibody measurement in this setting. The aim of this retrospective multicentre study was to investigate ZnT8A as a complement to the current T1D autoantibody assays in a large cohort of paediatric Italian patients.

Methods: ZnT8A were assessed by ELISA in 213 T1DM paediatric patients referred to six different centres in North-East Italy. Read More

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http://dx.doi.org/10.1007/s13317-015-0068-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536236PMC
August 2015
2 Reads

Automation, consolidation, and integration in autoimmune diagnostics.

Auto Immun Highlights 2015 Aug 3;6(1-2):1-6. Epub 2015 Jul 3.

Department of Laboratory Medicine, Laboratory of Clinical Pathology, S. Maria degli Angeli Hospital, Via Montereale, 24, 33170, Pordenone, Italy,

Over the past two decades, we have witnessed an extraordinary change in autoimmune diagnostics, characterized by the progressive evolution of analytical technologies, the availability of new tests, and the explosive growth of molecular biology and proteomics. Aside from these huge improvements, organizational changes have also occurred which brought about a more modern vision of the autoimmune laboratory. The introduction of automation (for harmonization of testing, reduction of human error, reduction of handling steps, increase of productivity, decrease of turnaround time, improvement of safety), consolidation (combining different analytical technologies or strategies on one instrument or on one group of connected instruments) and integration (linking analytical instruments or group of instruments with pre- and post-analytical devices) opened a new era in immunodiagnostics. Read More

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http://dx.doi.org/10.1007/s13317-015-0067-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536237PMC
August 2015
8 Reads

Decreased serum cell-free DNA levels in rheumatoid arthritis.

Auto Immun Highlights 2015 Aug 27;6(1-2):23-30. Epub 2015 Jun 27.

284 Department of Biomolecular Chemistry, Institute for Molecules and Materials and Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.

Purpose: Recent studies have demonstrated that serum/plasma DNA and RNA molecules in addition to proteins can serve as biomarkers. Elevated levels of these nucleic acids have been found not only in acute, but also in chronic conditions, including autoimmune diseases. The aim of this study was to assess cell-free DNA (cfDNA) levels in sera of rheumatoid arthritis (RA) patients compared to controls. Read More

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http://link.springer.com/10.1007/s13317-015-0066-6
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http://dx.doi.org/10.1007/s13317-015-0066-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536238PMC
August 2015
7 Reads

Drugs in induction and treatment of idiopathic inflammatory myopathies.

Auto Immun Highlights 2014 Dec 19;5(3):95-100. Epub 2014 Oct 19.

Rheumatology Unit, Division of Rheumatology, Department of Medicine-DIMED, University of Padova, Via Giustiniani, 2, 35128 Padua, Italy.

Idiopathic inflammatory myopathies (IIM) are a rare disease; so far standardized therapy has not been adequately defined by national or international guidelines or recommendations. Corticosteroids are the mainstay of treatment, but these drugs are burdened by several side effects. Thus, additional treatment based on immunosuppressive agents, especially azathioprine, methotrexate, mycophenolate mofetil and cyclosporine, is often needed. Read More

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http://dx.doi.org/10.1007/s13317-014-0065-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386578PMC
December 2014
4 Reads

Assessment of patients with idiopathic inflammatory myopathies and isolated creatin-kinase elevation.

Auto Immun Highlights 2014 Dec 15;5(3):87-94. Epub 2014 Oct 15.

Rheumatology Unit, Division of Rheumatology, Department of Medicine-DIMED, University of Padova, Via Giustiniani, 2, 35128 Padua, Italy.

Idiopathic inflammatory myopathies (IIM) are a group of diseases characterized by inflammation of the skeletal muscle. Weakness, mainly affecting the proximal muscles, is the cardinal muscular symptom in IIM. In patients with dermatomyositis, peculiar skin lesions are observed. Read More

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http://dx.doi.org/10.1007/s13317-014-0063-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386581PMC
December 2014

Muscle biopsy features of idiopathic inflammatory myopathies and differential diagnosis.

Auto Immun Highlights 2014 Dec 10;5(3):77-85. Epub 2014 Sep 10.

Division of Rheumatology, Department of Medicine, University of Padua, Via Giustiniani, 35128 PADOVA, Padua, Italy.

The gold standard to characterize idiopathic inflammatory myopathies is the morphological, immunohistochemical and immunopathological analysis of muscle biopsy. Mononuclear cell infiltrates and muscle fiber necrosis are commonly shared histopathological features. Inflammatory cells that surround, invade and destroy healthy muscle fibers expressing MHC class I antigen are the typical pathological finding of polymyositis. Read More

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http://dx.doi.org/10.1007/s13317-014-0062-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386579PMC
December 2014
5 Reads

Myositis autoantibodies and clinical phenotypes.

Auto Immun Highlights 2014 Dec 23;5(3):69-75. Epub 2014 Aug 23.

Division of Rheumatology, Department of Medicine, University of Padova, Via Giustiniani, 2, 35128 Padua, Italy.

Autoantibodies are powerful diagnostic tools in idiopathic inflammatory myopathies, especially for confirming the diagnosis and contributing to the definition of disease subsets. They are present in over 80 % of patients with immuno-mediated myositis and directed towards ubiquitously expressed intracellular complexes. Most of these autoantibodies are reported also in other autoimmune diseases, while some are considered myositis-specific. Read More

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http://dx.doi.org/10.1007/s13317-014-0060-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386580PMC
December 2014
13 Reads

The introduction of anti-phosphatidylserine/prothrombin autoantibodies in the laboratory diagnostic process of anti-phospholipid antibody syndrome: 6 months of observation.

Auto Immun Highlights 2014 Sep 14;5(2):63-7. Epub 2014 Aug 14.

Immunepathology and Allergy, Department of Laboratory Medicine, University Hospital of Udine, Udine, Italy.

Purpose: To evaluate the impact of the introduction of the anti-phosphatidylserine/prothrombin autoantibodies (aPS/PT) in the laboratory diagnostic process of anti-phospholipid antibody syndrome (APS).

Methods: Four hundred and twenty-one patients (71.5 % females; 53 ± 15 years) presenting a medical prescription for aPS/PT antibodies were consecutively enrolled in the study from March 2013 to August 2013. Read More

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http://dx.doi.org/10.1007/s13317-014-0061-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389041PMC
September 2014
2 Reads