Front Psychiatry 2022 6;13:862410. Epub 2022 Jun 6.
Developmental Brain Disorders Laboratory, INSERM UMR 1163, Imagine Institute, Université Paris Cité, Paris, France.
Next-generation sequencing techniques have accelerated the discovery of rare mutations responsible for autism spectrum disorder (ASD) in genes involved in a large number of physiological processes, including the control of gene expression, chromatin remodeling, signaling pathways, synaptic scaffolding, neurotransmitter receptors, and lipid metabolism. Genetic diagnosis provides subjects with an explanation of the cause of their disorder. However, it does not, or at least does not yet, shed light on the psychopathological phenomena specific to the individual. Read More