891 results match your criteria Autism Research[Journal]


Using latent class analysis to identify treatment-use subgroups among parents of children with autism spectrum disorder.

Autism Res 2019 Apr 16. Epub 2019 Apr 16.

Department of Pediatrics, Baylor College of Medicine, Houston, Texas.

Among parents of 2,582 children (ages 4-17 years old) with autism spectrum disorder (ASD), we used latent class analysis to identify subgroups and profiles of treatment users and included annual household income in the specification of the models, then described characteristics of each subgroup. Based on three indicators of fit (Akaike's Information Criterion, Bayesian Information Criterion, and Lo-Mendell-Rubin), six latent classes of treatment users emerged. Subgroups included users of: (a) mostly private and school speech and occupational therapies; (b) nearly all treatment types; (c) mostly speech and occupational therapies, plus intensive behavioral and "other" treatments, but little medication use; (d) private therapies almost exclusively; (e) primarily psychotropic medications; and (f) mostly school-based therapies. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/aur.2107
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http://dx.doi.org/10.1002/aur.2107DOI Listing
April 2019
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Enhanced Social Dominance and Altered Neuronal Excitability in the Prefrontal Cortex of Male KCC2b Mutant Mice.

Autism Res 2019 Apr 12. Epub 2019 Apr 12.

Roche Pharmaceutical Research and Early Development, Neuroscience, Ophthalmology and Rare Diseases, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland.

The K-Cl cotransporter KCC2 is essential in the development of the "GABA switch" that produces a change in neuronal responses to GABA signaling from excitatory to inhibitory early in brain development, and alterations in this progression have previously been hypothesized to play a causal role in autism spectrum disorder (ASD). We investigated the KCC2b (Slc12a5) heterozygous knockout mouse using a battery of rodent behavioral tests relevant to core and comorbid ASD symptoms. Compared to wild-type littermates, KCC2 mice were normal in standard measures of locomotor activity, grooming and digging behaviors, and social, vocalization, and anxiety-like behaviors. Read More

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http://dx.doi.org/10.1002/aur.2098DOI Listing

Early processing (N170) of infant faces in mothers of children with autism spectrum disorder and its association with maternal sensitivity.

Autism Res 2019 Apr 11. Epub 2019 Apr 11.

School of Psychology, Universidad Nacional Autónoma de México, Mexico City, Mexico.

Individuals with autism spectrum disorder (ASD) exhibit impaired adult facial processing, as shown by the N170 event-related potential. However, few studies explore such processing in mothers of children with ASD, and none has assessed the early processing of infant faces in these women. Moreover, whether processing of infant facial expressions in mothers of children with ASD is related to their response to their child's needs (maternal sensitivity [MS]) remains unknown. Read More

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http://dx.doi.org/10.1002/aur.2102DOI Listing

Reduced heart rate variability in adults with autism spectrum disorder.

Autism Res 2019 Apr 10. Epub 2019 Apr 10.

Autism Clinic for Translational Research, Brain and Mind Centre, Children's Hospital Westmead Clinical School, Faculty of Medicine and Health, University of Sydney, New South Wales, Australia.

A growing body of research has suggested heart rate variability (HRV) may be reduced in autism spectrum disorder (ASD) in comparison to neurotypical cohorts. While there have been several studies investigating HRV in children diagnosed with ASD, few studies have been conducted in adults. The objective of the current study was to investigate autonomic nervous system activity as assessed by HRV in adults diagnosed with ASD. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/aur.2104
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http://dx.doi.org/10.1002/aur.2104DOI Listing
April 2019
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Academic and psychosocial characteristics of incoming college freshmen with autism spectrum disorder: The role of comorbidity and gender.

Autism Res 2019 Apr 10. Epub 2019 Apr 10.

University of California, Los Angeles, California.

There is a pressing need to better characterize the college-bound population of individuals with autism spectrum disorder (ASD), as prior studies have included small samples, consisting of individuals who are either recruited due to diagnosis or are treatment seeking. As postsecondary institutions look to respond to the growing need for support services for individuals with ASD, insights derived from large, population-based samples is a necessity. The current study included a sample of over 2000 incoming postsecondary students who self-identified with ASD as a part of surveys distributed by institutions nationally. Read More

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http://dx.doi.org/10.1002/aur.2099DOI Listing
April 2019
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Maternal diabetes and hypertensive disorders in association with autism spectrum disorder.

Autism Res 2019 Apr 10. Epub 2019 Apr 10.

The University of North Carolina, Chapel Hill, North Carolina.

Previous studies have shown complications of pregnancy, often examined in aggregate, to be associated with autism spectrum disorder (ASD). Results for specific complications, such as maternal diabetes and hypertension, have not been uniformly consistent and should be investigated independently in relation to ASD in a large community-based sample. The Study to Explore Early Development (SEED), a US multisite case-control study, enrolled children born in 2003-2006 at 2-5 years of age. Read More

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http://dx.doi.org/10.1002/aur.2105DOI Listing
April 2019
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Sleep determines quality of life in autistic adults: A longitudinal study.

Autism Res 2019 Apr 10. Epub 2019 Apr 10.

Dr. Leo Kannerhuis and REACH-AUT, Doorwerth, The Netherlands.

Many individuals with autism report generally low quality of life (QoL). Identifying predictors for pathways underlying this outcome is an urgent priority. We aim to examine multivariate patterns that predict later subjective and objective QoL in autistic individuals. Read More

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http://dx.doi.org/10.1002/aur.2103DOI Listing

Parent-reported prevalence of food allergies in children with autism spectrum disorder: National health interview survey, 2011-2015.

Autism Res 2019 Apr 9. Epub 2019 Apr 9.

Department of Epidemiology and Biostatistics, Drexel University School of Public Health, Philadelphia, Pennsylvania.

Food allergies are frequently reported to co-occur with autism spectrum disorder (ASD), but the prevalence of this co-occurrence remains uncertain. In the present study, we examined parent-reported prevalence of co-occurring food allergy and ASD in a nationally representative sample of US children ages 2-17 in the National Health Interview Survey, study years 2011-2015. All analyses used survey weights to account for the complex sampling design. Read More

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http://dx.doi.org/10.1002/aur.2106DOI Listing
April 2019
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Short report: Relationships between sensory processing, repetitive behaviors, anxiety, and intolerance of uncertainty in autism spectrum disorder and Williams syndrome.

Autism Res 2019 Mar 28. Epub 2019 Mar 28.

Institute of Neuroscience, Sir James Spence Institute, Newcastle University, Newcastle upon Tyne, UK.

Autism spectrum disorder (ASD) and Williams syndrome (WS) share psychopathology relating to sensory processing and repetitive behaviors. The relationships between the sensory features and repetitive behaviors in both disorders, and the mechanisms underlying these relationships are not well understood. The aim of this study was to examine the relationships between sensory processing, repetitive behaviors, anxiety, and intolerance of uncertainty in children with ASD and those with WS to better understand the complexity of psychopathology in these disorders. Read More

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http://dx.doi.org/10.1002/aur.2096DOI Listing
March 2019
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Flourishing in children with autism spectrum disorders.

Autism Res 2019 Mar 26. Epub 2019 Mar 26.

Occupational Therapy Department, University of Texas Medical Branch, School of Health Professions, 301 University Boulevard, Galveston, Texas, 77555-1142.

Flourishing is an indicator of positive mental health and is important for children's development and well-being. We used variables from the National Survey of Children's Health 2016 as indicators of flourishing (difficulty making friends, is bullied, bullies others, shares ideas with family, argues, finishes tasks, does all homework, shows curiosity, stays calm, and cares about doing well in school) to compare differences in parent perceptions of their children with and without autism spectrum disorder (ASD). We anticipate that these findings will help identify intervention targets to support the well-being of individuals with ASD. Read More

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http://dx.doi.org/10.1002/aur.2097DOI Listing
March 2019
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Assessing a Hyperarousal Hypothesis of Insomnia in Adults with Autism Spectrum Disorder.

Autism Res 2019 Mar 21. Epub 2019 Mar 21.

Department of Mathematics and Statistics, La Trobe University, Bundoora, VIC, Australia.

This study aimed to investigate the relationship between sleep, psychopathology (anxiety, depression and presleep arousal) symptoms, and cortisol in adults with autism spectrum disorder (ASD). The sample composed of 29 adults with ASD (51.7% males) and 29 control adults (51. Read More

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http://dx.doi.org/10.1002/aur.2094DOI Listing
March 2019
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Meeting the 24-hr movement guidelines: An update on US youth with autism spectrum disorder from the 2016 National Survey of Children's Health.

Autism Res 2019 Mar 20. Epub 2019 Mar 20.

Department of Behavioral Health and Nutrition, University of Delaware, Newark, Delaware.

The purpose of this study was to examine how adherence to the physical activity (PA), screen-time (ST), and sleep duration guidelines differ between youth with autism spectrum disorder (ASD) and youth with typical development (TD). A secondary objective was to assess how PA, ST, and sleep duration varied among youth with ASD by age and ASD severity. Utilizing the 2016 National Survey of Children's Health data, parental reports of time spent by youth in PA, ST, and sleep were used to determine adherence to the 24-hr movement guidelines for 1008 youth with ASD and 34 489 youth with TD. Read More

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http://dx.doi.org/10.1002/aur.2095DOI Listing
March 2019
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The Use of Eye Tracking as a Biomarker of Treatment Outcome in a Pilot Randomized Clinical Trial for Young Children with Autism.

Autism Res 2019 Mar 20. Epub 2019 Mar 20.

Department of Counseling, Clinical, and School Psychology, University of California Santa Barbara, Santa Barbara, California.

There is a pressing need for objective, quantifiable outcome measures in intervention trials for children with autism spectrum disorder (ASD). The current study investigated the use of eye tracking as a biomarker of treatment response in the context of a pilot randomized clinical trial of treatment for young children with ASD. Participants included 28 children with ASD, aged 18-48 months, who were randomized to one of two conditions: Pivotal Response Intervention for Social Motivation (PRISM) or community treatment as usual (TAU). Read More

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http://dx.doi.org/10.1002/aur.2093DOI Listing
March 2019
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Newborn vitamin D levels in relation to autism spectrum disorders and intellectual disability: A case-control study in california.

Autism Res 2019 Mar 18. Epub 2019 Mar 18.

Kaiser Permanente Division of Research, Oakland, California.

Vitamin D deficiency has been increasing concurrently with prevalence of autism spectrum disorders (ASD), and emerging evidence suggests vitamin D is involved in brain development. Most prior studies of ASD examined vitamin D levels in children already diagnosed, but a few examined levels during perinatal development, the more likely susceptibility period. Therefore, we examined newborn vitamin D levels in a case-control study conducted among births in 2000-2003 in southern California. Read More

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http://dx.doi.org/10.1002/aur.2092DOI Listing
March 2019
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Association Between Breastfeeding Initiation and Duration and Autism Spectrum Disorder in Preschool Children Enrolled in the Study to Explore Early Development.

Autism Res 2019 Mar 9. Epub 2019 Mar 9.

Centers for Disease Control and Prevention, National Center on Birth Defects and Developmental Disabilities, Atlanta, Georgia.

Studies report inconsistent findings on the relationship between ASD and breastfeeding. We explored associations between ASD and breastfeeding initiation (yes/no) and duration (months categorized in tertiles) in the Study to Explore Early Development, a community-based case-control study in six sites in the Unites States. We adjusted for various child and mother demographic and pregnancy factors. Read More

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http://doi.wiley.com/10.1002/aur.2091
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http://dx.doi.org/10.1002/aur.2091DOI Listing
March 2019
6 Reads

Social and nonsocial reward moderate the relation between autism symptoms and loneliness in adults with ASD, depression, and controls.

Autism Res 2019 Mar 2. Epub 2019 Mar 2.

Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee.

Individuals with autism spectrum disorder (ASD) report high levels of co-occurring mood disorders. Previous work suggests that people with ASD also experience aberrant responses to social reward compared to typically developing (TD) peers. In the TD population, aberrant reward processing has been linked to anhedonia (i. Read More

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http://dx.doi.org/10.1002/aur.2088DOI Listing

Social and delay discounting in autism spectrum disorder.

Autism Res 2019 Feb 28. Epub 2019 Feb 28.

Department of Psychology, University of Maryland, College Park, MD, 20742.

Current literature is divided over whether and how processes such as perspective taking and reward sensitivity differ between individuals with autism spectrum disorder (ASD) versus neurotypical individuals. Discounting tasks may provide novel insight into how these processes operate. In delay discounting tasks, participants choose between smaller immediate rewards and larger delayed rewards, and in social discounting tasks, participants choose between a smaller monetary rewards for themselves versus a larger reward for partners of varied social distance (e. Read More

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http://dx.doi.org/10.1002/aur.2085DOI Listing
February 2019
2 Reads

Social and Nonsocial Visual Prediction Errors in Autism Spectrum Disorder.

Autism Res 2019 Feb 25. Epub 2019 Feb 25.

Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Impaired predictive coding has been proposed as a framework to explain discrepancies between expectations and outcomes in autism spectrum disorder (ASD) that may contribute to core symptoms of the disorder. However, no eye tracking study has directly addressed this framework in the context of visual predictions of social and nonsocial stimuli. The current study used eye tracking to examine violations of learned visual associations of both social and nonsocial stimuli. Read More

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http://dx.doi.org/10.1002/aur.2090DOI Listing
February 2019
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Mortality and cause of death of Australians on the autism spectrum.

Autism Res 2019 Feb 25. Epub 2019 Feb 25.

Department of Developmental Disability Neuropsychiatry, UNSW Sydney, New South Wales, Australia.

Focused investigations regarding mortality rates, risk factors, and cause of death in autistic populations remain scarce. The present study used large linked datasets spanning 2001-2015 to report the rates and risk factors for mortality and cause of death in individuals on the autism spectrum (n = 35,929 age range 5-64) with and without concurrent intellectual disability (ID) in New South Wales, Australia. Mortality rates for those on the autism spectrum were 2. Read More

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http://dx.doi.org/10.1002/aur.2086DOI Listing
February 2019
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Familial risk of autism alters subcortical and cerebellar brain anatomy in infants and predicts the emergence of repetitive behaviors in early childhood.

Autism Res 2019 Apr 22;12(4):614-627. Epub 2019 Feb 22.

Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

Autism spectrum disorder (ASD) is a common neurodevelopmental condition, and infant siblings of children with ASD are at a higher risk of developing autistic traits or an ASD diagnosis, when compared to those with typically developing siblings. Reports of differences in brain anatomy and function in high-risk infants which predict later autistic behaviors are emerging, but although cerebellar and subcortical brain regions have been frequently implicated in ASD, no high-risk study has examined these regions. Therefore, in this study, we compared regional MRI volumes across the whole brain in 4-6-month-old infants with (high-risk, n = 24) and without (low-risk, n = 26) a sibling with ASD. Read More

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http://dx.doi.org/10.1002/aur.2083DOI Listing

Electrophysiological alterations in motor-auditory predictive coding in autism spectrum disorder.

Autism Res 2019 Apr 23;12(4):589-599. Epub 2019 Feb 23.

Department of Cognitive Neuropsychology, Tilburg University, 5000 LE Tilburg, The Netherlands.

The amplitude of the auditory N1 component of the event-related potential (ERP) is typically attenuated for self-initiated sounds, compared to sounds with identical acoustic and temporal features that are triggered externally. This effect has been ascribed to internal forward models predicting the sensory consequences of one's own motor actions. The predictive coding account of autistic symptomatology states that individuals with autism spectrum disorder (ASD) have difficulties anticipating upcoming sensory stimulation due to a decreased ability to infer the probabilistic structure of their environment. Read More

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http://dx.doi.org/10.1002/aur.2087DOI Listing

Psychometric evaluation of social cognitive measures for adults with autism.

Autism Res 2019 Feb 15. Epub 2019 Feb 15.

School of Behavioral and Brain Sciences, The University Of Texas At Dallas, Richardson, Texas, 75080.

Although social cognition is frequently identified as a target in clinical trials and psychosocial interventions for adults with autism spectrum disorder (ASD), these efforts are hampered by a lack of consensus and validation of social cognitive measures. The current study provides psychometric evaluation of 11 frequently used measures encompassing different subdomains of social cognition. Adults with autism (N = 103) and typically developing controls (N = 95) completed 11 commonly used social cognitive tasks spanning the domains of emotion processing, social perception, and mentalizing/theory of mind. Read More

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http://dx.doi.org/10.1002/aur.2084DOI Listing
February 2019
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Frontal lobe dysfunction underlies the differential word retrieval impairment in adolescents with high-functioning autism.

Autism Res 2019 Apr 13;12(4):600-613. Epub 2019 Feb 13.

Neuropsychology Laboratory, Department of Psychology, The Chinese University of Hong Kong, New Territories, Hong Kong SAR, China.

There is substantial evidence of word retrieval impairment as indicated by poor performance on the category fluency test in autism spectrum disorder (ASD). However, little is known about the neural mechanisms underlying this impairment. Functional neuroimaging studies have shown that the lateral frontal cortex plays a key role in flexible word retrieval. Read More

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http://dx.doi.org/10.1002/aur.2082DOI Listing

Investigating the factors underlying adaptive functioning in autism in the EU-AIMS Longitudinal European Autism Project.

Autism Res 2019 Apr 11;12(4):645-657. Epub 2019 Feb 11.

Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

Individuals with autism spectrum disorder (ASD) exhibit significant impairments in adaptive functioning that impact on their ability to meet the demands of everyday life. A recurrent finding is that there is a pronounced discrepancy between level of cognitive ability and adaptive functioning, and this is particularly prominent among higher-ability individuals. However, the key clinical and demographic associations of these discrepancies remain unclear. Read More

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http://dx.doi.org/10.1002/aur.2081DOI Listing
April 2019
8 Reads

A review of screening tools for the identification of autism spectrum disorders and developmental delay in infants and young children: recommendations for use in low- and middle-income countries.

Autism Res 2019 Feb 1;12(2):176-199. Epub 2019 Feb 1.

Department of Psychology, Stellenbosch University, Stellenbosch, South Africa.

Without intervention, developmental delay (DD) and autism spectrum disorders (ASDs) severely restrict children from reaching their developmental potential. Monitoring child development through the use of screening tools can help identify children who need further assessment or intervention. Screening has been widely encouraged to identify children with ASD or DD, and a large variety of screening instruments are suggested in the literature. Read More

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http://dx.doi.org/10.1002/aur.2033DOI Listing
February 2019
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Oral probiotic administration during pregnancy prevents autism-related behaviors in offspring induced by maternal immune activation via anti-inflammation in mice.

Autism Res 2019 Apr 25;12(4):576-588. Epub 2019 Jan 25.

Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, P. R. China.

Maternal immune activation (MIA) is associated with an increased risk for autism spectrum disorders (ASD) in offspring. Animal experiments have found that interleukin 6 (IL-6) and IL-17a are key cytokines in the induction of ASD by MIA. Moreover, probiotics were verified to inhibit the production of proinflammatory cytokines. Read More

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http://doi.wiley.com/10.1002/aur.2079
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http://dx.doi.org/10.1002/aur.2079DOI Listing
April 2019
9 Reads

Association between CNTNAP2 polymorphisms and autism: A family-based study in the chinese han population and a meta-analysis combined with GWAS data of psychiatric genomics consortium.

Autism Res 2019 Apr 25;12(4):553-561. Epub 2019 Jan 25.

Peking University Sixth Hospital, Beijing, 100191, China.

Autism is a childhood neuropsychiatric disorder with evidence of a strong genetic component in the complex etiologies. Contactin-associated protein-like 2 (CNTNAP2), a member of the neurexin superfamily, plays an essential role in neural development. CNTNAP2 was considered as one of the most susceptible genes for autism spectrum disorder (ASD). Read More

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http://dx.doi.org/10.1002/aur.2078DOI Listing
April 2019
3 Reads

Profiles of vocalization change in children with autism receiving early intervention.

Autism Res 2019 Jan 24. Epub 2019 Jan 24.

A.J. Drexel Autism Institute, Drexel University, Philadelphia, Pennsylvania.

Children with autism spectrum disorder (ASD) commonly present with comorbid language impairment, negatively impacting their learning and participation across settings. Addressing these needs requires a detailed understanding of their communication trajectories. In this study, we used the language environment and analysis (LENA) system to examine possible changes in children's (a) vocalizations and (b) ratio of speech to nonspeech vocalizations over a 10-month period. Read More

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http://dx.doi.org/10.1002/aur.2075DOI Listing
January 2019
1 Read

Predictors of mental health and well-being in employed adults with autism spectrum disorder at 12-month follow-up.

Autism Res 2019 Mar 24;12(3):482-494. Epub 2019 Jan 24.

Olga Tennison Autism Research Centre, La Trobe University, Melbourne, VIC, Australia.

People with Autism Spectrum Disorder (ASD) commonly experience poor outcomes in adulthood. Previous research on adult outcomes has focused on negative aspects of health and well-being, while positive well-being remains understudied. The current study charted 12-month change in daily living skills, job satisfaction, depression, anxiety, and positive well-being in 36 (32 male) newly employed adults with ASD aged 18 to 57 years who were participating in a supported employment program. Read More

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http://dx.doi.org/10.1002/aur.2064DOI Listing

Cognitive and behavioral differences in toddlers with autism spectrum disorder from multiplex and simplex families.

Autism Res 2019 Apr 21;12(4):682-693. Epub 2019 Jan 21.

Olga Tennison Autism Research Centre, La Trobe University, Melbourne Campus, Bundoora, Victoria, Australia.

Prospective, longitudinal designs utilizing "high-risk" infant siblings of children diagnosed with Autism Spectrum Disorder (ASD-sibs) have provided unique and valuable insights regarding the early ASD phenotype. However, it remains unclear whether these cases are representative of all children with ASD. The objective in the present study was to investigate whether the early development of toddlers with ASD from multiplex (MPX) families, who have an affected older sibling, is similar or different to toddlers with ASD from simplex (SPX) families, where there is no affected sibling. Read More

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http://doi.wiley.com/10.1002/aur.2074
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http://dx.doi.org/10.1002/aur.2074DOI Listing
April 2019
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Measuring child social communication across contexts: Similarities and differences across play and snack routines.

Autism Res 2019 Apr 21;12(4):636-644. Epub 2019 Jan 21.

Department of Psychology, Michigan State University, East Lansing, Michigan.

Improving measurement of outcomes in randomized controlled trials of early interventions for autism spectrum disorder (ASD) has been identified as a priority in the field. In addition, the importance of measurement across contexts has been indicated by researchers and community stakeholders alike [Lord et al., ; McConachie et al. Read More

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http://dx.doi.org/10.1002/aur.2077DOI Listing
April 2019
1 Read

Atomoxetine for attention deficit hyperactivity disorder in children and adolescents with autism: A systematic review and meta-analysis.

Autism Res 2019 Apr 17;12(4):542-552. Epub 2019 Jan 17.

Cochrane South Asia, Christian Medical College, Vellore, India.

Atomoxetine is prescribed to children with autism spectrum disorder having symptoms of attention deficit hyperactivity disorder. We sought to examine the efficacy and safety of atomoxetine in this population. After screening for inclusion criteria, we identified three randomized placebo controlled trials involving 241 children. Read More

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http://doi.wiley.com/10.1002/aur.2059
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http://dx.doi.org/10.1002/aur.2059DOI Listing
April 2019
4 Reads

Hypothesis-driven investigations of diverse pharmacological targets in two mouse models of autism.

Autism Res 2019 Mar 17;12(3):401-421. Epub 2019 Jan 17.

MIND Institute, Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, Sacramento, California, 95817.

Autism spectrum disorder is a neurodevelopmental syndrome diagnosed primarily by persistent deficits in social interactions and communication, unusual sensory reactivity, motor stereotypies, repetitive behaviors, and restricted interests. No FDA-approved medical treatments exist for the diagnostic symptoms of autism. Here we interrogate multiple pharmacological targets in two distinct mouse models that incorporate well-replicated autism-relevant behavioral phenotypes. Read More

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http://dx.doi.org/10.1002/aur.2066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402976PMC
March 2019
1 Read

How effective is LENA in detecting speech vocalizations and language produced by children and adolescents with ASD in different contexts?

Autism Res 2019 Apr 14;12(4):628-635. Epub 2019 Jan 14.

Department of Psychological and Brain Sciences, Boston University, Boston, Massachusetts.

The LENA system was designed and validated to provide information about the language environment in children 0 to 4 years of age and its use has been expanded to populations with a number of communication profiles. Its utility in children 5 years of age and older is not yet known. The present study used acoustic data from two samples of children with autism spectrum disorders (ASD) to evaluate the reliability of LENA automated analyses for detecting speech utterances in older, school age children, and adolescents with ASD, in clinic and home environments. Read More

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http://dx.doi.org/10.1002/aur.2071DOI Listing
April 2019
1 Read

Tactile hypersensitivity and GABA concentration in the sensorimotor cortex of adults with autism.

Autism Res 2019 Apr 11;12(4):562-575. Epub 2019 Jan 11.

Lyon Neuroscience Research Center, Brain Dynamics and Cognition Team, INSERM UMRS 1028, CNRS UMR 5292, Université Claude Bernard Lyon 1, Université de Lyon, F-69000, Lyon, France.

Sensory hypersensitivity is frequently encountered in autism spectrum disorder (ASD). Gamma-aminobutyric acid (GABA) has been hypothesized to play a role in tactile hypersensitivity. The aim of the present study was twofold. Read More

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http://dx.doi.org/10.1002/aur.2073DOI Listing

Brief social attention bias modification for children with autism spectrum disorder.

Autism Res 2019 Mar 10;12(3):527-535. Epub 2019 Jan 10.

Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia.

Reduced social attention is a hallmark feature in autism spectrum disorder (ASD), emerging as early as the first year of life. This difference represents a possible mechanism impacting upon the development of more complex social-communicative behaviors. The aim of this study was to develop and test the efficacy of a novel attention bias modification paradigm to alter social attention, specifically orienting to faces. Read More

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http://dx.doi.org/10.1002/aur.2067DOI Listing
March 2019
2 Reads

Comparing the 1-year impact of preschool autism intervention programs in two Canadian provinces.

Autism Res 2019 Apr 10;12(4):667-681. Epub 2019 Jan 10.

Department of Health and Wellness, Government of Nova Scotia, Halifax, Nova Scotia, Canada.

Autism spectrum disorder (ASD) is associated with early differences in children's social interactions, communication, and play/interests. In many countries, considerable resources are invested in early intensive behavioral intervention (EIBI) programs for children with ASD, which aim to build adaptive skills and prevent or treat problem behavior. However, these programs vary widely in structure and delivery. Read More

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http://doi.wiley.com/10.1002/aur.2072
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http://dx.doi.org/10.1002/aur.2072DOI Listing
April 2019
26 Reads

Social complexity and the early social environment affect visual social attention to faces.

Autism Res 2019 Mar 10;12(3):445-457. Epub 2019 Jan 10.

Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California.

Diminished attention to socially relevant information appears to be an early emerging risk factor associated with autism spectrum disorders (ASD). However, inconsistencies across studies suggest that atypicalities in visual social attention in infants at high-risk for ASD during the first postnatal year may be subtle and more apparent under certain contexts. Here we explore factors that may moderate developmental trajectories in attention to faces, including the social complexity of the dynamic visual stimuli used to measure visual social attention and the early social environment of the infant as indexed by parental affectedness of ASD-related traits. Read More

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http://doi.wiley.com/10.1002/aur.2060
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http://dx.doi.org/10.1002/aur.2060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402992PMC
March 2019
6 Reads

The neurobiological presentation of anxiety in autism spectrum disorder: A systematic review.

Authors:
Alana J McVey

Autism Res 2019 Mar 10;12(3):346-369. Epub 2019 Jan 10.

Marquette University, Milwaukee, Wisconsin.

Anxiety is common among people with autism and is associated with unique and additive challenges. Anxiety is thought to have neurobiological components, and measures of arousal in typical development have long been studied. Recently, neurobiological measures of anxiety in autism have begun to receive empirical evaluation, but results have not yet been examined together. Read More

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http://dx.doi.org/10.1002/aur.2063DOI Listing

SHANK1 polymorphisms and SNP-SNP interactions among SHANK family: A possible cue for recognition to autism spectrum disorder in infant age.

Autism Res 2019 Mar 10;12(3):375-383. Epub 2019 Jan 10.

Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, Jilin, China.

Autism spectrum disorder (ASD) is a serious lifelong neurodevelopmental disorder. ASD is diagnosed for children at the age of two. ASD diagnosis, as early as possible, lays the foundation for treatment and much better prognosis. Read More

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http://doi.wiley.com/10.1002/aur.2065
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http://dx.doi.org/10.1002/aur.2065DOI Listing
March 2019
15 Reads

Treatment patterns in children with autism in the United States.

Autism Res 2019 Mar 10;12(3):517-526. Epub 2019 Jan 10.

Personalized Health Care Data Science, Real World Data, F. Hoffmann-La Roche Ltd., Basel, Switzerland.

Children with autism receive different types of non-drug treatments. We aimed to describe caregiver-reported pattern of care and its variability by geography and healthcare coverage in a US-wide sample of children aged 3-17 years. We recruited caregivers from the Simons Foundation Powering Autism Research for Knowledge (SPARK) cohort. Read More

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http://doi.wiley.com/10.1002/aur.2070
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http://dx.doi.org/10.1002/aur.2070DOI Listing
March 2019
36 Reads

Inferring power and dominance from dyadic nonverbal interactions in autism spectrum disorder.

Autism Res 2019 Mar 10;12(3):505-516. Epub 2019 Jan 10.

Department of Psychiatry and Psychotherapy, University Hospital Cologne, Cologne, Germany.

Research studies to date have revealed conflicting results with respect to the processing of nonverbal cues from social interactions in autism spectrum disorder (ASD). Therefore, the aim of the present study was to investigate the contribution of two important factors for the perception of dyadic social interactions, namely (a) the movement contingency and (b) the spatial context. To this end, 26 adult participants with ASD and 26 age-, sex-, and IQ-matched typically developed control participants observed animations presenting nonverbal interactions between two human virtual characters enacting power relationships. Read More

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http://dx.doi.org/10.1002/aur.2069DOI Listing

The role of alexithymia in parent-child interaction and in the emotional ability of children with autism spectrum disorder.

Autism Res 2019 Mar 9;12(3):458-468. Epub 2019 Jan 9.

Institute for Health and Behaviour, INSIDE, University of Luxembourg, Esch-sur-Alzette, Luxembourg.

Children with autism spectrum disorder (ASD) have more emotional difficulties than typically developing (TD) children. Of all the factors that impact children's emotional development, parents, and the way they interact with their children, are of crucial importance. The present study compared the amount of parent-child interactions among 35 dyads of parents and their children with ASD and 41 dyads of parents and their TD children, aged between 3 and 13 years, during a frustration-eliciting situation. Read More

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http://doi.wiley.com/10.1002/aur.2061
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http://dx.doi.org/10.1002/aur.2061DOI Listing
March 2019
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Aberrant "deep connectivity" in autism: A cortico-subcortical functional connectivity magnetic resonance imaging study.

Autism Res 2019 Mar 9;12(3):384-400. Epub 2019 Jan 9.

Department of Psychology, University of Alabama at Birmingham, Alabama.

The number of studies examining functional brain networks in Autism Spectrum Disorder (ASD) has risen over the last decade and has characterized ASD as a disorder of altered brain connectivity. However, these studies have focused largely on cortical structures, and only a few studies have examined cortico-subcortical connectivity in regions like thalamus and basal ganglia in ASD. The goal of this study was to characterize the functional connectivity between cortex and subcortical regions in ASD using the Autism Brain Imaging Data Exchange (ABIDE-II). Read More

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Dyadic interactions in children exhibiting the broader autism phenotype: Is the broader autism phenotype distinguishable from typical development?

Autism Res 2019 Mar 9;12(3):469-481. Epub 2019 Jan 9.

Department of Psychological Sciences, Purdue University, West Lafayette, Indiana.

In families raising a child with an autism spectrum disorder (ASD), infant siblings are at elevated risk for ASD and other developmental concerns, including elements of the broader autism phenotype (BAP). Typically, the BAP is indexed using standardized developmental assessments; however, these measures do not capture a number of social difficulties commonly associated with the BAP. The present study aims to expand our developmental understanding of the BAP by comparing children exhibiting the BAP to their typically developing peers on, (a) standardized measures of development, and (b) social behaviors exhibited during dyadic play interactions. Read More

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http://doi.wiley.com/10.1002/aur.2062
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March 2019
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The stability of joint engagement states in infant siblings of children with and without ASD: Implications for measurement practices.

Autism Res 2019 Mar 8;12(3):495-504. Epub 2019 Jan 8.

Department of Hearing and Speech Sciences, Vanderbilt University, Nashville, Tennessee.

Obtaining stable estimates of caregiver-child joint engagement states is of interest for researchers who study development and early intervention in young children with autism spectrum disorder (ASD). However, studies to date have offered little guidance on the numbers of sessions and coders necessary to obtain sufficiently stable estimates of these constructs. We used procedures derived from G theory to carry out a generalizability study, in which we partitioned error variance between two facets of our system for measuring joint engagement states: session and coder. Read More

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http://doi.wiley.com/10.1002/aur.2068
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http://dx.doi.org/10.1002/aur.2068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433374PMC
March 2019
6 Reads

Psychometric properties of the chinese version of autism spectrum quotient-children's version: A sex-specific analysis.

Autism Res 2019 Feb 28;12(2):303-315. Epub 2018 Dec 28.

Department of Maternal and Child Health, School of Public Health, Sun Yat-Sen University, Guangzhou, China.

A Simplified Chinese translation of the Autism Spectrum Quotient-Children's Version (AQ-C) is needed for research in mainland China. Autism Spectrum Disorder (ASD) is a condition that differs in presentation and prevalence by sex. Thus, evaluating the psychometric validity of the AQ-C in males and females is an important step in its validation. Read More

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http://dx.doi.org/10.1002/aur.2053DOI Listing
February 2019
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Faster eye movements in children with autism spectrum disorder.

Autism Res 2019 Feb 26;12(2):212-224. Epub 2018 Dec 26.

UMR 1253, iBrain, Université de Tours, Inserm, Tours, France.

Atypical visual exploration of both social and nonsocial scenes is often reported in Autism Spectrum Disorder (ASD) with less precise and longer saccades, potentially reflecting difficulties in oculomotor control. To assess a subset of oculomotor functions in ASD, 20 children with ASD and 21 age-matched typically developing (TD) children (2.6-11. Read More

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http://doi.wiley.com/10.1002/aur.2054
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February 2019
10 Reads