22,395 results match your criteria Austrian Journal Of Political Science[Journal]


Metformin loaded cholesterol-lysine conjugate nanoparticles: a novel approach for protecting HDFs against UVB-induced senescence.

Int J Pharm 2020 Jul 3:119603. Epub 2020 Jul 3.

Department of Pharmaceutical Sciences, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address:

Cellular senescence is one of the hallmarks of aging. Since senescence of dermal fibroblasts has been reported in vivo, reduction of the deleterious effects of these cells, has been considered an important intervention to counteract skin aging. Promising anti-aging effect of metformin has been reported. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2020.119603DOI Listing

The impact of managed entry agreements on pharmaceutical prices.

Health Econ 2020 Jul 6. Epub 2020 Jul 6.

Pharmacoeconomics Department, Gesundheit Österreich GmbH, Austrian National Public Health Institute, Vienna, Austria.

Managed entry agreements (MEAs) have been used for several years, with the aim of curbing the growth of pharmaceutical expenditure and enhancing patient access to innovation. Yet, much remains to be understood about their economic implications. This paper studies the impact of MEAs on list prices, that is, prices before the deduction of any discount. Read More

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http://dx.doi.org/10.1002/hec.4112DOI Listing

Joint venture on the further development of chemical exposure assessment by use of probabilistic modelling.

EFSA J 2019 Sep 17;17(Suppl 2):e170905. Epub 2019 Sep 17.

Exposure assessment is a fundamental component of the risk assessment process and has a significant contribution to the overall uncertainty of the risk estimates. The aim of the present project, implemented within the framework of the EU-FORA Fellowship, was to develop a structured approach for probabilistic modelling of the dietary exposure to chemical contaminants, which shall be used as a refined alternative to the more conservative deterministic approach or as part of a Tier 2 assessment. The fellow received training and worked in close cooperation with the project team on three case studies of contaminants in food (cadmium, acrylamide and deoxynivalenol). Read More

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http://dx.doi.org/10.2903/j.efsa.2019.e170905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015474PMC
September 2019

Soft sensor based on 2D-fluorescence and process data enabling real-time estimation of biomass in cultivations.

Eng Life Sci 2020 Jan 11;20(1-2):26-35. Epub 2019 Nov 11.

Department of Biotechnology University of Natural Resources and Life Sciences Vienna Austria.

In bioprocesses, specific process responses such as the biomass cannot typically be measured directly on-line, since analytical sampling is associated with unavoidable time delays. Accessing those responses in real-time is essential for Quality by Design and process analytical technology concepts. Soft sensors overcome these limitations by indirectly measuring the variables of interest using a previously derived model and actual process data in real time. Read More

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http://dx.doi.org/10.1002/elsc.201900076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6999058PMC
January 2020

Distinct responses in feed sorting, chewing behavior, and ruminal acidosis risk between primiparous and multiparous Simmental cows fed diets differing in forage and starch levels.

J Dairy Sci 2020 Jul 1. Epub 2020 Jul 1.

Institute of Animal Nutrition and Functional Plant Compounds, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine, Veterinärplatz 1, 1210 Vienna, Austria. Electronic address:

During early lactation, both primiparous (PP) and multiparous (MP) cows are commonly fed diets rich in starch and low in forages to support their high energy requirements. Yet, the PP cows experience this dietary challenge for the first time, which might result in higher odds for them to develop rumen and systemic health disorders. The primary objective of this study was to evaluate the effect of decreasing the amount of forages in the diet on chewing and sorting behaviors and rumen and systemic health variables in PP and MP dairy cows. Read More

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http://dx.doi.org/10.3168/jds.2019-17760DOI Listing

Analysis of Austrian COVID-19 deaths by age and sex.

Wien Klin Wochenschr 2020 Jul 3. Epub 2020 Jul 3.

Section for Medical Statistics, Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Spitalgasse 23, 1090, Vienna, Austria.

We analyze the age and sex distribution of the reported COVID-19 deaths in Austria. In accordance with international studies, the Austrian data also suggests that the risk of death increases substantially with age. The observed age dependency of the proportions of registered COVID-19 deaths in relation to the population sizes in the age groups is approximately exponential, similar to the age dependency of the general age specific mortality rate. Read More

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http://dx.doi.org/10.1007/s00508-020-01707-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333368PMC

META Score: An International Consensus Scoring System on Mesh-Tissue Adhesions.

World J Surg 2020 Jul 4. Epub 2020 Jul 4.

Department of General Surgery, Maastricht University Medical Centre, PO Box 5800, 6202 AZ, Maastricht, The Netherlands.

Background: Currently, the lack of consensus on postoperative mesh-tissue adhesion scoring leads to incomparable scientific results. The aim of this study was to develop an adhesion score recognized by experts in the field of hernia surgery.

Methods: Authors of three or more previously published articles on both mesh-tissue adhesion scores and postoperative adhesions were marked as experts. Read More

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http://dx.doi.org/10.1007/s00268-020-05568-1DOI Listing

Hybrid TRUS/CT with optical tracking for target delineation in image-guided adaptive brachytherapy for cervical cancer.

Strahlenther Onkol 2020 Jul 3. Epub 2020 Jul 3.

Department of Radiation Oncology, Comprehensive Cancer Center, General Hospital of Vienna, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.

Objective: To prospectively compare the interobserver variability of combined transrectal ultrasound (TRUS)/computed tomography (CT)- vs. CT only- vs. magnetic resonance imaging (MRI) only-based contouring of the high-risk clinical target volume (CTV) in image-guided adaptive brachytherapy (IGABT) for locally advanced cervical cancer (LACC). Read More

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http://dx.doi.org/10.1007/s00066-020-01656-2DOI Listing

Salmonella-based platform for efficient delivery of functional binding proteins to the cytosol.

Commun Biol 2020 Jul 3;3(1):342. Epub 2020 Jul 3.

IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.

Protein-based affinity reagents (like antibodies or alternative binding scaffolds) offer wide-ranging applications for basic research and therapeutic approaches. However, whereas small chemical molecules efficiently reach intracellular targets, the delivery of macromolecules into the cytosol of cells remains a major challenge; thus cytosolic applications of protein-based reagents are rather limited. Some pathogenic bacteria have evolved a conserved type III secretion system (T3SS) which allows the delivery of effector proteins into eukaryotic cells. Read More

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http://dx.doi.org/10.1038/s42003-020-1072-4DOI Listing

What CHO is made of: Variations in the biomass composition of Chinese hamster ovary cell lines.

Metab Eng 2020 Jun 30. Epub 2020 Jun 30.

Acib - Austrian Centre of Industrial Biotechnology, 1190, Vienna, Austria, EU; Department of Biotechnology, University of Natural Resources and Life Sciences, Vienna, 1190, Vienna, Austria, EU; Department of Analytical Chemistry, University of Vienna, 1010, Vienna, Austria, EU. Electronic address:

Background: Cell line-specific, genome-scale metabolic models enable rigorous and systematic in silico investigation of cellular metabolism. Such models have recently become available for Chinese hamster ovary (CHO) cells. However, a key ingredient, namely an experimentally validated biomass function that summarizes the cellular composition, was so far missing. Read More

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http://dx.doi.org/10.1016/j.ymben.2020.06.002DOI Listing

Condensin: The Little Motor Protein that Could.

Mol Cell 2020 Jul;79(1):3-5

Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna BioCenter, Vienna, Austria. Electronic address:

Kong et al. (2020) present the low-resolution structure of the ATPɣS-bound human condensin I and II complexes and demonstrate that human condensins can extrude DNA loops in a symmetric and asymmetric fashion and compact nucleosome-bound DNA. Read More

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http://dx.doi.org/10.1016/j.molcel.2020.06.025DOI Listing

Reference charts for body composition parameters by dual-energy X-ray absorptiometry in European children and adolescents aged 6 to 18 years-Results from the Austrian LEAD (Lung, hEart, sociAl, boDy) cohort.

Pediatr Obes 2020 Jul 2:e12695. Epub 2020 Jul 2.

Ludwig Boltzmann Institute for COPD and Respiratory Epidemiology, Vienna, Austria.

Background: DXA is a widely used technique to assess body composition. Reference values based on a large general population cohort of European children and adolescents were missing. The aim of this study was to provide age- and sex-specific reference percentiles of body composition parameters for European children and adolescents and to compare them to the American NHANES cohort. Read More

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http://dx.doi.org/10.1111/ijpo.12695DOI Listing

Identification of the amino acid position controlling the different enzymatic activities in walnut tyrosinase isoenzymes (jrPPO1 and jrPPO2).

Sci Rep 2020 Jul 2;10(1):10813. Epub 2020 Jul 2.

Universität Wien, Fakultät für Chemie, Institut für Biophysikalische Chemie, Althanstraße 14, 1090, Wien, Austria.

Polyphenol oxidases (PPOs) are ubiquitously distributed among plants, bacteria, fungi and animals. They catalyze the hydroxylation of monophenols (monophenolase activity) and the oxidation of o-diphenols (diphenolase activity) to o-quinones. PPOs are commonly present as an isoenzyme family. Read More

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http://dx.doi.org/10.1038/s41598-020-67415-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331820PMC

Non-occupational exposure to phthalates in Finland.

Toxicol Lett 2020 Jun 29. Epub 2020 Jun 29.

Finnish Institute of Occupational Health, PO Box 40, FI-00032 Työterveyslaitos, Finland.

The aim of this study was to assess phthalate exposure of non-occupationally exposed working aged population in Finland. Studied phthalates included diethyl phthalate (DEP), di-n-butyl phthalate (DnBP), diisobutyl phthalate (DiBP), benzyl butyl phthalate (BzBP), dicyclohexyl phthalate (DCHP), di(2-ethylhexyl) phthalate (DEHP), diisononyl phthalate (DiNP), diisodecyl phthalate (DiDP), di(2-propylheptyl) phthalate (DPHP), and di-n-octyl phthalate (DnOP). Sample collection campaign took place in 2015. Read More

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http://dx.doi.org/10.1016/j.toxlet.2020.06.021DOI Listing

Matrix metalloproteinase 15 plays a pivotal role in human first trimester cytotrophoblast invasion and is not altered by maternal obesity.

FASEB J 2020 Jul 2. Epub 2020 Jul 2.

Department of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria.

Adequate anchoring of the placenta in the uterus through invasion of first trimester cytotrophoblasts (CTB) is required for a successful pregnancy. This process is mediated by matrix metalloproteinases (MMPs) and regulated by the maternal environment. Obesity is known to alter the intrauterine milieu and has been related to impaired invasion. Read More

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http://dx.doi.org/10.1096/fj.202000773RDOI Listing

In situ based surface-enhanced Raman spectroscopy (SERS) for the fast and reproducible identification of PHB producers in cyanobacterial cultures.

Analyst 2020 Jul 2. Epub 2020 Jul 2.

Austrian Biotech University of Applied Sciences, Konrad Lorenz-Straße 10, 3430 Tulln, Austria.

The production of polyhydroxybutyrate (PHB) by autotrophic fermentation of cyanobacteria has received increasing interest in the light of carbon emission reducing process strategies. Biotechnological approaches are in development to optimize the yield of PHB, including adapted cultivation media, characterized by a limitation of key nutrients: cyanobacteria accumulate PHB as energy storage molecules under limited growth conditions. Since there is an increasing demand for fast, simple and reliable analytics, we report the establishment of surface enhanced Raman spectroscopy (SERS) as a suitable monitoring tool for up scaled PHB production processes. Read More

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http://dx.doi.org/10.1039/d0an00969eDOI Listing

An epidemic CC1-MRSA-IV clone yields false-negative test results in molecular MRSA identification assays: a note of caution, Austria, Germany, Ireland, 2020.

Euro Surveill 2020 Jun;25(25)

Friedrich- Schiller University; Institute of Physical Chemistry, Jena, Germany.

We investigated why a clinical meticillin-resistant (MRSA) isolate yielded false-negative results with some commercial PCR tests for MRSA detection. We found that an epidemic European CC1-MRSA-IV clone generally exhibits this behaviour. The failure of the assays was attributable to a large insertion in the /SCC integration site. Read More

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http://dx.doi.org/10.2807/1560-7917.ES.2020.25.25.2000929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331142PMC

Directed evolution approach to enhance efficiency and speed of outgrowth during single cell subcloning of Chinese Hamster Ovary cells.

Comput Struct Biotechnol J 2020 2;18:1320-1329. Epub 2020 Jun 2.

ACIB Gmbh, Austrian Centre of Industrial Biotechnology, Vienna, Austria.

Chinese Hamster Ovary (CHO) cells are the working horse of the pharmaceutical industry. To obtain high producing cell clones and to satisfy regulatory requirements single cell cloning is a necessary step in cell line development. However, it is also a tedious, labor intensive and expensive process. Read More

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http://dx.doi.org/10.1016/j.csbj.2020.05.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306589PMC

A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dubé syndrome.

Nature 2020 Jul 1. Epub 2020 Jul 1.

Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy.

The mechanistic target of rapamycin complex 1 (mTORC1) is a key metabolic hub that controls the cellular response to environmental cues by exerting its kinase activity on multiple substrates. However, whether mTORC1 responds to diverse stimuli by differentially phosphorylating specific substrates is poorly understood. Here we show that transcription factor EB (TFEB), a master regulator of lysosomal biogenesis and autophagy, is phosphorylated by mTORC1 via a substrate-specific mechanism that is mediated by Rag GTPases. Read More

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http://dx.doi.org/10.1038/s41586-020-2444-0DOI Listing

Structural cells are key regulators of organ-specific immune responses.

Nature 2020 Jul 1. Epub 2020 Jul 1.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

The mammalian immune system implements a remarkably effective set of mechanisms for fighting pathogens. Its main components are haematopoietic immune cells, including myeloid cells that control innate immunity, and lymphoid cells that constitute adaptive immunity. However, immune functions are not unique to haematopoietic cells, and many other cell types display basic mechanisms of pathogen defence. Read More

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http://dx.doi.org/10.1038/s41586-020-2424-4DOI Listing

A remnant planetary core in the hot-Neptune desert.

Authors:
David J Armstrong Théo A Lopez Vardan Adibekyan Richard A Booth Edward M Bryant Karen A Collins Magali Deleuil Alexandre Emsenhuber Chelsea X Huang George W King Jorge Lillo-Box Jack J Lissauer Elisabeth Matthews Olivier Mousis Louise D Nielsen Hugh Osborn Jon Otegi Nuno C Santos Sérgio G Sousa Keivan G Stassun Dimitri Veras Carl Ziegler Jack S Acton Jose M Almenara David R Anderson David Barrado Susana C C Barros Daniel Bayliss Claudia Belardi Francois Bouchy César Briceño Matteo Brogi David J A Brown Matthew R Burleigh Sarah L Casewell Alexander Chaushev David R Ciardi Kevin I Collins Knicole D Colón Benjamin F Cooke Ian J M Crossfield Rodrigo F Díaz Elisa Delgado Mena Olivier D S Demangeon Caroline Dorn Xavier Dumusque Philipp Eigmüller Michael Fausnaugh Pedro Figueira Tianjun Gan Siddharth Gandhi Samuel Gill Erica J Gonzales Michael R Goad Maximilian N Günther Ravit Helled Saeed Hojjatpanah Steve B Howell James Jackman James S Jenkins Jon M Jenkins Eric L N Jensen Grant M Kennedy David W Latham Nicholas Law Monika Lendl Michael Lozovsky Andrew W Mann Maximiliano Moyano James McCormac Farzana Meru Christoph Mordasini Ares Osborn Don Pollacco Didier Queloz Liam Raynard George R Ricker Pamela Rowden Alexandre Santerne Joshua E Schlieder Sara Seager Lizhou Sha Thiam-Guan Tan Rosanna H Tilbrook Eric Ting Stéphane Udry Roland Vanderspek Christopher A Watson Richard G West Paul A Wilson Joshua N Winn Peter Wheatley Jesus Noel Villasenor Jose I Vines Zhuchang Zhan

Nature 2020 Jul 1;583(7814):39-42. Epub 2020 Jul 1.

Department of Earth, Atmospheric and Planetary Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.

The interiors of giant planets remain poorly understood. Even for the planets in the Solar System, difficulties in observation lead to large uncertainties in the properties of planetary cores. Exoplanets that have undergone rare evolutionary processes provide a route to understanding planetary interiors. Read More

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http://dx.doi.org/10.1038/s41586-020-2421-7DOI Listing

Scalable High-Performance Production of Recombinant Horseradish Peroxidase from Inclusion Bodies.

Int J Mol Sci 2020 Jun 29;21(13). Epub 2020 Jun 29.

TU Wien, Institute of Chemical, Environmental and Bioscience Engineering, Research Area Biochemical Engineering, Gumpendorfer Straße 1a, 1060 Vienna, Austria.

Horseradish peroxidase (HRP), an enzyme omnipresent in biotechnology, is still produced from hairy root cultures, although this procedure is time-consuming and only gives low yields. In addition, the plant-derived enzyme preparation consists of a variable mixture of isoenzymes with high batch-to-batch variation preventing its use in therapeutic applications. In this study, we present a novel and scalable recombinant HRP production process in that yields a highly pure, active and homogeneous single isoenzyme. Read More

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http://dx.doi.org/10.3390/ijms21134625DOI Listing

Acid bone lysates reduce bone regeneration in rat calvaria defects.

J Biomed Mater Res A 2020 Jun 30. Epub 2020 Jun 30.

Department of Oral Biology, School of Dentistry, Medical University of Vienna, Austria.

Acid bone lysates represent the growth factors and other molecules released during autologous graft resorption. However, the impact of these bone-derived growth factors on the healing of bone defects has not yet been investigated. The aim of the present study was, therefore, to examine the impact of acid bone lysates adsorbed to collagen membranes on bone regeneration. Read More

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http://dx.doi.org/10.1002/jbm.a.37050DOI Listing

Determination of ammonia and hydrogen sulfide emissions from a commercial dairy farm with an exercise yard and the health-related impact for residents.

Environ Sci Pollut Res Int 2020 Jun 30. Epub 2020 Jun 30.

WG Environmental Health, Unit for Physiology and Biophysics, University of Veterinary Medicine, Vienna, Austria.

Airborne emissions from concentrated animal feeding operations (CAFOs) have the potential to pose a risk to human health and the environment. Here, we present an assessment of the emission, dispersion, and health-related impact of ammonia and hydrogen sulfide emitted from a 300-head, full-scale dairy farm with an exercise yard in Beijing, China. By monitoring the referred gas emissions with a dynamic flux chamber for seven consecutive days, we examined their emission rates. Read More

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http://dx.doi.org/10.1007/s11356-020-09858-yDOI Listing

Neuronal αδ proteins and brain disorders.

Pflugers Arch 2020 Jun 30. Epub 2020 Jun 30.

Institute of Physiology, Medical University Innsbruck, 6020, Innsbruck, Austria.

αδ proteins are membrane-anchored extracellular glycoproteins which are abundantly expressed in the brain and the peripheral nervous system. They serve as regulatory subunits of voltage-gated calcium channels and, particularly in nerve cells, regulate presynaptic and postsynaptic functions independently from their role as channel subunits. αδ proteins are the targets of the widely prescribed anti-epileptic and anti-allodynic drugs gabapentin and pregabalin, particularly for the treatment of neuropathic pain conditions. Read More

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http://dx.doi.org/10.1007/s00424-020-02420-2DOI Listing

Coagulation disorders in Duchenne muscular dystrophy? Results of a registry-based online survey.

Acta Myol 2020 Mar 1;39(1):2-12. Epub 2020 Mar 1.

Department of Neuropediatrics and Muscle Disorders, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

Different complications of hemostasis have been reported in patients with Duchenne Muscular Dystrophy (DMD). These comprise an increased rate of bleeding-symptoms during scoliosis surgery but also thromboembolic complications such as pulmonary embolism, cerebral infarction, deep vein thrombosis or cardiac thrombus. For this cross-sectional study, personalized online survey-links were forwarded to 682 registered patients with a genetically confirmed diagnosis of DMD via the German-Austrian DMD patient registry (www. Read More

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http://dx.doi.org/10.36185/2532-1900-001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315897PMC

Automating image-based mesh generation and manipulation tasks in cardiac modeling workflows using Meshtool.

SoftwareX 2020 Jan-Jun;11:100454. Epub 2020 Mar 20.

Gottfried Schatz Research Center: Division of Biophysics, Medical University of Graz, Graz, Austria.

Advanced cardiac modeling studies rely on the ability to generate and functionalize personalized models from tomographic multi-label image stacks. Eventually, this is used for building virtual cohorts that capture the variability in size, shape, and morphology of individual hearts. Typical modeling workflows involve a multitude of interactive mesh manipulation steps, rendering model generation expensive. Read More

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http://dx.doi.org/10.1016/j.softx.2020.100454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326605PMC

Intronic Variants in OCT1 are Associated with All-Cause and Cardiovascular Mortality in Metformin Users with Type 2 Diabetes.

Diabetes Metab Syndr Obes 2020 18;13:2069-2080. Epub 2020 Jun 18.

Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University Graz, Graz, Austria.

Purpose: Organic cation transporters (Octs) use cations like endogenous compounds, toxins, and drugs, such as metformin, as substrates. Therefore, these proteins determine the pharmacokinetics and -dynamics of metformin and thus its efficacy. Of note, metformin is today the most commonly used pharmaceutical in the treatment of type 2 diabetes (T2DM) with nevertheless a great variability in clinical response, which attributes to genetic variances. Read More

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http://dx.doi.org/10.2147/DMSO.S235663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308180PMC

Historical dataset of administrative units with social-economic attributes for Austrian Silesia 1837-1910.

Sci Data 2020 Jun 30;7(1):208. Epub 2020 Jun 30.

Jagiellonian University, Faculty of History, Institute of History, Kraków, Poland.

Scientists from many disciplines need historical administrative boundaries in order to analyse socio-economic data in space and time. In this paper, we present a set of historical data consisting of administrative unit boundaries and exemplary socio-economic attributes for Austrian Silesia, an historical region located in modern Czechia and Poland. The dataset covers nearly 700 administrative unit boundaries on the level of cadastral or political communes and their subparts and was acquired through manual vectorisation of historical maps (1:28,800) from the period 1837-1841. Read More

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http://dx.doi.org/10.1038/s41597-020-0546-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326999PMC

Microbiome definition re-visited: old concepts and new challenges.

Microbiome 2020 Jun 30;8(1):103. Epub 2020 Jun 30.

Helmholtz Zentrum München, Oberschleissheim, Germany.

The field of microbiome research has evolved rapidly over the past few decades and has become a topic of great scientific and public interest. As a result of this rapid growth in interest covering different fields, we are lacking a clear commonly agreed definition of the term "microbiome." Moreover, a consensus on best practices in microbiome research is missing. Read More

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http://dx.doi.org/10.1186/s40168-020-00875-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329523PMC

Platelet-Rich Fibrin Can Neutralize Hydrogen Peroxide-Induced Cell Death in Gingival Fibroblasts.

Antioxidants (Basel) 2020 06 26;9(6). Epub 2020 Jun 26.

Department of Oral Biology, Medical University of Vienna, 1090 Vienna, Austria.

Hydrogen peroxide is a damage signal at sites of chronic inflammation. The question arises whether platelet-rich fibrin (PRF), platelet-poor plasma (PPP), and the buffy coat can neutralize hydrogen peroxide toxicity and thereby counteract local oxidative stress. In the present study, gingival fibroblasts cells were exposed to hydrogen peroxide with and without lysates obtained from PRF membranes, PPP, heated PPP (75 °C for 10 min), and the buffy coat. Read More

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http://dx.doi.org/10.3390/antiox9060560DOI Listing

Does the Use of the "Proseek Multiplex Oncology I Panel" on Peritoneal Fluid Allow a Better Insight in the Pathophysiology of Endometriosis, and in Particular Deep-Infiltrating Endometriosis?

J Clin Med 2020 Jun 26;9(6). Epub 2020 Jun 26.

Department of Obstetrics and Gynecology, Medical University of Vienna, 1090 Vienna, Austria.

Endometriosis appears to share certain cancer-related processes, such as cell attachment, invasion, proliferation and neovascularization, some of which can also be found in other healthy tissues. In order to better understand the altered milieu of the peritoneal cavity, while acknowledging the reported similarities between endometriosis and neoplastic processes, we applied a multiplex oncology panel to search for specific biomarker signatures in the peritoneal fluid of women with endometriosis, women with deep-infiltrating endometriosis (DIE), as well as controls. In total, 84 patients were included in our study, 53 women with endometriosis and 31 controls. Read More

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http://dx.doi.org/10.3390/jcm9062009DOI Listing

Availability of Standardized Electronic Patient Data in Nursing: A Nationwide Survey of Austrian Acute Care Hospitals.

Stud Health Technol Inform 2020 Jun;272:233-236

UMIT - Private University for Health Sciences, Medical Informatics and Technology.

A large amount of patient data is produced and documented in patient care. Health care professionals expect that this routinely collected patient data can also be used for secondary purposes such as measuring the quality of care or to gain new knowledge. Routine data needs to be documented in a standardized form, based on clinical terminologies, to allow this secondary use of data. Read More

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http://dx.doi.org/10.3233/SHTI200537DOI Listing

Dose Calculations and Dose-Effect Relationships in 177Lu-PSMA I&T Radionuclide Therapy for Metastatic Castration-Resistant Prostate Cancer.

Clin Nucl Med 2020 Jun 25. Epub 2020 Jun 25.

From the Preclinical Molecular Imaging, AIT Austrian Institute of Technology GmbH, Seibersdorf.

Dose response of 22 patients experiencing mCRPC (metastatic castration-resistant prostate cancer) to Lu-PSMA I&T radionuclide therapy was investigated. Dosimetry calculations are used to assess correlations between dosimetric quantities and biomarker values.

Methods: The patients' age range was 74 ± 7 years at the time of the investigated treatment cycle, and the mean injected activity was 7416 ± 218 MBq. Read More

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http://dx.doi.org/10.1097/RLU.0000000000003157DOI Listing

Womb at work: The missing impact of maternal employment on newborn health.

Authors:
Caroline Chuard

J Health Econ 2020 Jun 15;73:102342. Epub 2020 Jun 15.

University of Zurich, Department of Economics, Schönberggasse 1, 8001 Zurich, Switzerland. Electronic address:

Parental leave policies across the globe have become much more generous than they used to be. This is also true for prenatal maternal leave. While this may be costly in the short run, little is known about the effect of maternal employment during pregnancy on newborn health. Read More

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http://dx.doi.org/10.1016/j.jhealeco.2020.102342DOI Listing

Age-of-onset information helps identify 76 genetic variants associated with allergic disease.

PLoS Genet 2020 Jun 30;16(6):e1008725. Epub 2020 Jun 30.

University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Pediatric Pulmonology and Pediatric Allergology, and University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands.

Risk factors that contribute to inter-individual differences in the age-of-onset of allergic diseases are poorly understood. The aim of this study was to identify genetic risk variants associated with the age at which symptoms of allergic disease first develop, considering information from asthma, hay fever and eczema. Self-reported age-of-onset information was available for 117,130 genotyped individuals of European ancestry from the UK Biobank study. Read More

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http://dx.doi.org/10.1371/journal.pgen.1008725DOI Listing

A novel FRET peptide assay reveals efficient Helicobacter pylori HtrA inhibition through zinc and copper binding.

Sci Rep 2020 Jun 29;10(1):10563. Epub 2020 Jun 29.

Microbiology, Department of Biosciences, University of Salzburg, Billrothstrasse 11, 5020, Salzburg, Austria.

Helicobacter pylori (H. pylori) secretes the chaperone and serine protease high temperature requirement A (HtrA) that cleaves gastric epithelial cell surface proteins to disrupt the epithelial integrity and barrier function. First inhibitory lead structures have demonstrated the essential role of HtrA in H. Read More

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http://dx.doi.org/10.1038/s41598-020-67578-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324608PMC

EGFR/Ras-induced CCL20 production modulates the tumour microenvironment.

Br J Cancer 2020 Jun 30. Epub 2020 Jun 30.

Department of Dermatology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.

Background: The activation of the EGFR/Ras-signalling pathway in tumour cells induces a distinct chemokine repertoire, which in turn modulates the tumour microenvironment.

Methods: The effects of EGFR/Ras on the expression and translation of CCL20 were analysed in a large set of epithelial cancer cell lines and tumour tissues by RT-qPCR and ELISA in vitro. CCL20 production was verified by immunohistochemistry in different tumour tissues and correlated with clinical data. Read More

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http://dx.doi.org/10.1038/s41416-020-0943-2DOI Listing

Sport participation after the HandbikeBattle: benefits, barriers, facilitators from the event-a follow-up survey.

Spinal Cord Ser Cases 2020 Jun 29;6(1):54. Epub 2020 Jun 29.

University of Groningen, University Medical Center Groningen, Center for Rehabilitation, Groningen, The Netherlands.

Objectives: To investigate sports participation among individuals in the HandbikeBattle project 1.5-5.5 years after the event, the barriers and facilitators to sport participation and benefits of participating in the event. Read More

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http://dx.doi.org/10.1038/s41394-020-0301-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324566PMC

An Updated Review of Pro- and Anti-Inflammatory Properties of Plasma Lysophosphatidylcholines in the Vascular System.

Int J Mol Sci 2020 Jun 24;21(12). Epub 2020 Jun 24.

Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, 8010 Graz, Austria.

Lysophosphatidylcholines are a group of bioactive lipids heavily investigated in the context of inflammation and atherosclerosis development. While present in plasma during physiological conditions, their concentration can drastically increase in certain inflammatory states. Lysophosphatidylcholines are widely regarded as potent pro-inflammatory and deleterious mediators, but an increasing number of more recent studies show multiple beneficial properties under various pathological conditions. Read More

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http://dx.doi.org/10.3390/ijms21124501DOI Listing

Sleep coaching: non-pharmacological treatment of non-restorative sleep in Austrian railway shift workers.

Arh Hig Rada Toksikol 2019 Sep;70(3):186-193

Institute for Consciousness and Dream Research, Vienna, Austria.

Sleep coaching by Holzinger & Klösch™ is a new, Gestalt therapy-based holistic approach to non-pharmacological treatment of non-restorative sleep. It includes psychotherapeutic aspects which enable participants to improve their sleep quality by developing their own coping strategies as a daily routine. Dream work and relaxation techniques are also part of the programme. Read More

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http://dx.doi.org/10.2478/aiht-2019-70-3244DOI Listing
September 2019

Sexual dimorphism in facial shape of modern Buryats of Southern Siberia.

Am J Hum Biol 2020 Jun 28:e23458. Epub 2020 Jun 28.

Institute of Ethnology and Anthropology, Russian Academy of Sciences, Moscow, Russia.

Objectives: The aim of the present study was to investigate sexual dimorphism in the full facial shape of modern Buryats-people of Southern Siberia of Mongolian origin.

Methods: For this purpose, we have used geometric morphometrics based on standardized full-face frontal photographs. This allowed us to assess and visualize differences in facial shapes between Buryat men (n = 98) and women (n = 89). Read More

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http://dx.doi.org/10.1002/ajhb.23458DOI Listing

Pericardial variant of Austrian syndrome.

Rev Esp Cardiol (Engl Ed) 2020 Jun 25. Epub 2020 Jun 25.

Servicio de Cardiología, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain; Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.rec.2020.03.021DOI Listing

CD8+CD28null T Lymphocytes are Associated with the Development of Atrial Fibrillation after Elective Cardiac Surgery.

Thromb Haemost 2020 Jun 28. Epub 2020 Jun 28.

Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.

Background:  Postoperative atrial fibrillation (POAF) is assumed as a complex and multifactorial interaction of different pathogenic factors. Data suggests an inflammatory process as the main trigger of this specific type of atrial fibrillation. CD8 T lymphocytes that lack the surface protein CD28 were found to be crucially involved in chronic inflammatory processes within the cardiovascular system. Read More

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http://dx.doi.org/10.1055/s-0040-1713096DOI Listing

Health Literacy in Austria: Interventions and Research.

Stud Health Technol Inform 2020 Jun;269:192-201

University of Vienna, Austria.

This report provides an overview of Austria's approaches to improve population health literacy (HL). The report suggests: a) research can trigger health policy responses to improve HL; b) linking HL improvement to other reform agendas can boost effectiveness, and c) coordination is required for continuously and systematically working towards better HL. Examples of strategic thematic approaches and interventions - especially in the fields of communication in healthcare, health information products, and organizational HL responsiveness - are provided, and Austria's role in preparing the next European HL survey, HLS19, is briefly described. Read More

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http://dx.doi.org/10.3233/SHTI200032DOI Listing

Health Literacy Measurement in General and Other Populations: Further Initiatives and Lessons Learned in Europe (and Beyond).

Stud Health Technol Inform 2020 Jun;269:170-191

Agency for Preventive and Social Medicine, Bregenz, Austria.

This chapter provides an overview of health literacy measurement initiatives with a focus on the European Health Literacy Survey (HLS-EU) - describing where measuring population health literacy started, where it currently is, and providing an outlook to the upcoming European HL survey. In the first part of the chapter, the methodology and the main results of the initial HLS-EU study from 2011 will be introduced. In the second part the worldwide impact of the HLS-EU study will be mapped. Read More

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http://dx.doi.org/10.3233/SHTI200031DOI Listing

Can reminders improve adherence to regular physical activity and exercise recommendations in people over 60 years old? : A randomized controlled study.

Wien Klin Wochenschr 2020 Jun 26. Epub 2020 Jun 26.

Department of Physical Medicine, Rehabilitation and Occupational Medicine, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.

Purpose: The purpose of the study was to investigate whether additional reminders could enhance adherence to a 12-week program consisting of regular physical activity.

Methods: The study collective consisted of pensioners insured with the Austrian Insurance Fund for Civil or Public Servants. They were made aware of our program through the public service union. Read More

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http://dx.doi.org/10.1007/s00508-020-01699-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318722PMC

Prospects of activity limitations among older adults in 23 low and middle income countries.

Sci Rep 2020 Jun 26;10(1):10442. Epub 2020 Jun 26.

Wittgenstein Centre (IIASA, VID/ÖAW, WU), International Institute for Applied Systems Analysis (IIASA), Schlossplatz 1, 2361, Laxenburg, Austria.

Increasing life expectancy and a growing share of older people around the world spotlight the issue of health during additional years of life. Research on trends of proportions of older people with activity limitations for low and middle income countries is sparse. We use data from the World Health Survey and the UN World Population Prospects to predict prevalence of activity limitations for 23 low and middle income countries for the upcoming 30 years. Read More

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http://dx.doi.org/10.1038/s41598-020-67166-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319965PMC

Response to: 'Eosinophilic granulomatosis with polyangiitis can manifest lacrimal and salivary glands swelling by granulomatous inflammation: a potential mimicker of IgG4-related disease' by Akiyama .

Ann Rheum Dis 2020 Jun 26. Epub 2020 Jun 26.

Ludwig Boltzmann Institute of Osteology at Hanusch Hospital of Österreichische Gesundheitskasse (ÖGK) and Research Funds of the Austrian Workers Compensation Board (AUVA),1st Medical Department, Hanusch Hospital, Wien, Austria.

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http://dx.doi.org/10.1136/annrheumdis-2020-218174DOI Listing