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Austrian Journal Of Political Science[J... Publications | PubFacts

17,727 results match your criteria Austrian Journal Of Political Science[Journal]


Interruptive Versus Noninterruptive Clinical Decision Support: Usability Study.

JMIR Hum Factors 2019 Apr 17;6(2):e12469. Epub 2019 Apr 17.

Department of Medicine, New York University School of Medicine, New York, NY, United States.

Background: Clinical decision support (CDS) has been shown to improve compliance with evidence-based care, but its impact is often diminished because of issues such as poor usability, insufficient integration into workflow, and alert fatigue. Noninterruptive CDS may be less subject to alert fatigue, but there has been little assessment of its usability.

Objective: This study aimed to study the usability of interruptive and noninterruptive versions of a CDS. Read More

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http://dx.doi.org/10.2196/12469DOI Listing

Increasing use of immunotherapy and prolonged survival among younger patients with primary CNS lymphoma: a population-based study.

Acta Oncol 2019 Apr 17:1-10. Epub 2019 Apr 17.

a Institute of Neurology , Medical University of Vienna , Vienna , Austria.

Background: Primary CNS lymphoma is a highly aggressive and rare type of extranodal non-Hodgkin lymphoma. Although, new therapeutic approaches have led to improved survival, the management of the disease poses a challenge, practice patterns vary across institutions and countries, and remain ill-defined for vulnerable patient subgroups.

Material And Methods: Using information from the Austrian Brain Tumor Registry we followed a population-based cohort of 189 patients newly diagnosed from 2005 to 2010 through various lines of treatment until death or last follow-up (12-31-2016). Read More

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http://dx.doi.org/10.1080/0284186X.2019.1599137DOI Listing

Summary of the Second Congress of the International Society for Apheresis-European Group and the Austrian Apheresis Association.

Ther Apher Dial 2018 Aug;22(4):317-318

President, Austrian Apheresis Association, ATHOS Institute, Vienna, Austria.

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http://dx.doi.org/10.1111/1744-9987.12722DOI Listing

Practical guidance for engaging patients in health research, treatment guidelines and regulatory processes: results of an expert group meeting organized by the World Health Organization (WHO) and the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO).

Aging Clin Exp Res 2019 Apr 16. Epub 2019 Apr 16.

WHO Collaborating Centre for Public Health Aspects of Musculoskeletal Health and Aging, Liège, Belgium.

There is increasing emphasis on patient-centred research to support the development, approval and reimbursement of health interventions that best meet patients' needs. However, there is currently little guidance on how meaningful patient engagement may be achieved. An expert working group, representing a wide range of stakeholders and disciplines, was convened by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the World Health Organization (WHO). Read More

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http://dx.doi.org/10.1007/s40520-019-01193-8DOI Listing

Quantum localization bounds Trotter errors in digital quantum simulation.

Sci Adv 2019 Apr 12;5(4):eaau8342. Epub 2019 Apr 12.

Institute for Quantum Optics and Quantum Information of the Austrian Academy of Sciences, 6020 Innsbruck, Austria.

A fundamental challenge in digital quantum simulation (DQS) is the control of an inherent error, which appears when discretizing the time evolution of a quantum many-body system as a sequence of quantum gates, called Trotterization. Here, we show that quantum localization-by constraining the time evolution through quantum interference-strongly bounds these errors for local observables, leading to an error independent of system size and simulation time. DQS is thus intrinsically much more robust than suggested by known error bounds on the global many-body wave function. Read More

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http://dx.doi.org/10.1126/sciadv.aau8342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461450PMC

Higher dose but not low dose proton pump inhibitors are associated with increased risk of subsequent hip fractures after first hip fracture: A nationwide observational cohort study.

Bone Rep 2019 Jun 1;10:100204. Epub 2019 Apr 1.

Ludwig Boltzmann Institute of Osteology, Hanusch Hospital of the WGKK and AUVA Trauma Center, 1 Medical Department at Hanusch Hospital, Heinrich Collin Str. 30, 1140 Vienna, Austria.

Aim: To examine the association of proton pump inhibitor (PPI) use with subsequent hip fracture incidence in hip fracture patients, accounting for gender, age, PPI doses, PPI initiation before or after first fracture, and year from first fracture in which the first subsequent fracture occurred.

Methods: Data from 31,668 Austrian patients ≥50 years with the first hip fracture between July 2008 and December 2010 were analyzed retrospectively. After exclusion of patients on anti-osteoporotic medication, incidence of subsequent hip fractures was compared between users and non-users of PPIs using regression models. Read More

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http://dx.doi.org/10.1016/j.bonr.2019.100204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451165PMC

Brevibacterium from Austrian hard cheese harbor a putative histamine catabolism pathway and a plasmid for adaptation to the cheese environment.

Sci Rep 2019 Apr 16;9(1):6164. Epub 2019 Apr 16.

Interdepartmental Microbiology Graduate Program Iowa State University, Ames, IA, USA.

The genus Brevibacterium harbors many members important for cheese ripening. We performed real-time quantitative PCR (qPCR) to determine the abundance of Brevibacterium on rinds of Vorarlberger Bergkäse, an Austrian artisanal washed-rind hard cheese, over 160 days of ripening. Our results show that Brevibacterium are abundant on Vorarlberger Bergkäse rinds throughout the ripening time. Read More

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http://dx.doi.org/10.1038/s41598-019-42525-yDOI Listing

Aspirin impairs acetyl-coenzyme A metabolism in redox-compromised yeast cells.

Sci Rep 2019 Apr 16;9(1):6152. Epub 2019 Apr 16.

Centre for Molecular Medicine and Biobanking, University of Malta, Msida, Malta.

Aspirin is a widely used anti-inflammatory and antithrombotic drug also known in recent years for its promising chemopreventive antineoplastic properties, thought to be mediated in part by its ability to induce apoptotic cell death. However, the full range of mechanisms underlying aspirin's cancer-preventive properties is still elusive. In this study, we observed that aspirin impaired both the synthesis and transport of acetyl-coenzyme A (acetyl-CoA) into the mitochondria of manganese superoxide dismutase (MnSOD)-deficient Saccharomyces cerevisiae EG110 yeast cells, but not of the wild-type cells, grown aerobically in ethanol medium. Read More

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http://dx.doi.org/10.1038/s41598-019-39489-4DOI Listing

Enzymatic synthesis of lignin derivable pyridine based polyesters for the substitution of petroleum derived plastics.

Nat Commun 2019 Apr 16;10(1):1762. Epub 2019 Apr 16.

The University of York, Department of Chemistry, Green Chemistry Centre of Excellence, YO10 5DD, Heslington, York, UK.

Following concerns over increasing global plastic pollution, interest in the production and characterization of bio-based and biodegradable alternatives is rising. In the present work, the synthesis of a series of fully bio-based alternatives based on 2,4-, 2,5-, and 2,6-pyridinedicarboxylic acid-derived polymers produced via enzymatic catalysis are reported. A similar series of aromatic-aliphatic polyesters based on diethyl-2,5-furandicarboxylate and of the petroleum-based diethyl terephthalate and diethyl isophthalate were also synthesized. Read More

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http://dx.doi.org/10.1038/s41467-019-09817-3DOI Listing

Charcot-Marie-Tooth disease type 2CC due to a frameshift mutation of the neurofilament heavy polypeptide gene in an Austrian family.

Neuromuscul Disord 2019 Feb 20. Epub 2019 Feb 20.

Friedrich-Baur-Institute, Dep. of Neurology, Ludwig-Maximilians-University of Munich, Ziemssenstraße 1A, 80336 Munich, Germany. Electronic address:

Neurofilaments are structural components of motor axons. Recently different variants resulting in translation of a cryptic amyloidogenic element of the neurofilament-heavy polypeptide (NEFH) gene have been described to cause Charcot-Marie-Tooth disease type 2CC (CMT2CC) by forming amyloidogenic toxic protein aggregation. Until now only few CMT2CC patients have been described. Read More

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http://dx.doi.org/10.1016/j.nmd.2019.02.007DOI Listing
February 2019

Metabopolis: scalable network layout for biological pathway diagrams in urban map style.

BMC Bioinformatics 2019 Apr 15;20(1):187. Epub 2019 Apr 15.

Research Division of Computer Graphics, Institute of Visual Computing and Human- Centered Technology, TU Wien, Vienna, Austria.

Background: Biological pathways represent chains of molecular interactions in biological systems that jointly form complex dynamic networks. The network structure changes from the significance of biological experiments and layout algorithms often sacrifice low-level details to maintain high-level information, which complicates the entire image to large biochemical systems such as human metabolic pathways.

Results: Our work is inspired by concepts from urban planning since we create a visual hierarchy of biological pathways, which is analogous to city blocks and grid-like road networks in an urban area. Read More

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http://dx.doi.org/10.1186/s12859-019-2779-4DOI Listing

Next-Generation Hedgehog/GLI Pathway Inhibitors for Cancer Therapy.

Cancers (Basel) 2019 Apr 15;11(4). Epub 2019 Apr 15.

Department of Biosciences, Paris-Lodron University of Salzburg, Cancer Cluster Salzburg, Hellbrunner Strasse 34, 5020 Salzburg, Austria.

The Hedgehog/Glioma-associated oncogene homolog (HH/GLI) signaling pathway regulates self-renewal of rare and highly malignant cancer stem cells (CSC), which have been shown to account for the initiation and maintenance of tumor growth as well as for drug resistance, metastatic spread and relapse. Efficacious therapeutic approaches targeting CSC pathways, such as HH/GLI signaling in combination with chemo, radiation or immunotherapy are, therefore, of high medical need. Pharmacological inhibition of HH/GLI pathway activity represents a promising approach to eliminate malignant CSC. Read More

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https://www.mdpi.com/2072-6694/11/4/538
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http://dx.doi.org/10.3390/cancers11040538DOI Listing
April 2019
1 Read

Involvement of EP2 and EP4 Receptors in Eosinophilic Esophagitis: A Pilot Study.

Dig Dis Sci 2019 Apr 15. Epub 2019 Apr 15.

Otto Loewi Research Center, Divison of Pharmacology, Medical University of Graz, Universitätsplatz 4, 8010, Graz, Austria.

Background: The prostaglandin D receptor DP2 has been implicated in eosinophil infiltration and the development of eosinophilic esophagitis (EoE).

Aims And Methods: In this study, we investigated an involvement of PGE (EP1-EP4) and PGD (DP1) receptors in EoE by measuring their expression in peripheral blood eosinophils and esophageal mucosal biopsies of EoE patients and by performing migration and adhesion assays with eosinophils from healthy donors.

Results: Expression of EP2 and EP4, but not EP1 and EP3, was decreased in blood eosinophils of patients with EoE vs. Read More

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http://dx.doi.org/10.1007/s10620-019-05623-5DOI Listing

Age-related course of visual acuity obtained with ETDRS 2000 charts in persons with healthy eyes.

Graefes Arch Clin Exp Ophthalmol 2019 Apr 15. Epub 2019 Apr 15.

Department of Development Studies, Sensengasse 3, 1090, Vienna, Austria.

Purpose: To investigate the age-related course of best-corrected visual acuity in healthy eyes.

Methods: Two hundred participants (400 eyes) 25 to 74 years of age (114 females, 86 males) were investigated, 20 per 5-year age group. Best-corrected visual acuity was measured monocularly with the ETDRS 2000 charts at a distance of 4 m (Precision Vision, Woodstock, IL, USA). Read More

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http://dx.doi.org/10.1007/s00417-019-04320-3DOI Listing

Exploring Farmers' Climate Change Perceptions and Adaptation Intentions: Empirical Evidence from Austria.

Environ Manage 2019 Apr 16. Epub 2019 Apr 16.

Institute for Sustainable Economic Development, Department of Economics and Social Sciences at the University of Natural Resources and Life Sciences, Vienna, Feistmantelstrasse 4, 1180, Vienna, Austria.

The lack of timely adaptation in agriculture may hamper prosperous farm developments by neglecting risks and opportunities emerging from climate change. Understanding farmers' perceptual and socio-cognitive processes is key in order to encourage on-farm adaptation. We aim at investigating how farmers' individual cognition on climate change and adaptation as well as socio-environmental context factors affect agricultural adaptation intention and avoidance. Read More

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http://dx.doi.org/10.1007/s00267-019-01158-7DOI Listing

Difference in reproductive mode rather than ploidy explains niche differentiation in sympatric sexual and apomictic populations of .

Ecol Evol 2019 Mar 5;9(6):3588-3598. Epub 2019 Mar 5.

Department of Forest Genetics Austrian Research Centre for Forests Vienna Austria.

Apomicts tend to have larger geographical distributional ranges and to occur in ecologically more extreme environments than their sexual progenitors. However, the expression of apomixis is typically linked to polyploidy. Thus, it is a priori not clear whether intrinsic effects related to the change in the reproductive mode or rather in the ploidy drive ecological differentiation. Read More

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http://dx.doi.org/10.1002/ece3.4992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434561PMC

The horse Y chromosome as an informative marker for tracing sire lines.

Sci Rep 2019 Apr 15;9(1):6095. Epub 2019 Apr 15.

Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, 1210, Austria.

Analysis of the Y chromosome is the best-established way to reconstruct paternal family history in humans. Here, we applied fine-scaled Y-chromosomal haplotyping in horses with biallelic markers and demonstrate the potential of our approach to address the ancestry of sire lines. We de novo assembled a draft reference of the male-specific region of the Y chromosome from Illumina short reads and then screened 5. Read More

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http://dx.doi.org/10.1038/s41598-019-42640-wDOI Listing

Experimental Chemistry and Structural Stability of AlNb₃ Enabled by Antisite Defects Formation.

Materials (Basel) 2019 Apr 3;12(7). Epub 2019 Apr 3.

Department of Materials Science, Montanuniversität Leoben, Franz-Josef-Strasse 18, A-8700 Leoben, Austria.

First-principles evolutionary algorithms are employed to shed light on the phase stability of Al⁻Nb intermetallics. While the tetragonal Al₃Nb and AlNb₂ structures are correctly identified as stable, the experimentally reported Laves phase of AlNb₃ yields soft phonon modes implying its dynamical instability at 0 K. The soft phonon modes do not disappear even upon elevating the temperature in the simulation up to 1500 K. Read More

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http://dx.doi.org/10.3390/ma12071104DOI Listing

Specific detection and differentiation of tick-borne encephalitis and West Nile virus induced IgG antibodies in humans and horses.

Transbound Emerg Dis 2019 Apr 15. Epub 2019 Apr 15.

Fraunhofer Institute for Cell Therapy and Immunology, Department of Immunology, Perlickstrasse 1, 04103, Leipzig, Germany.

Tick-borne encephalitis virus (TBEV) and West Nile virus (WNV) are important arthropod-borne zoonotic flaviviruses. Due to the emergence of WNV in TBEV-endemic regions co-circulation of both viruses is increasing. Flaviviruses are structurally highly similar, which leads to cross-reacting antibodies upon infection. Read More

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http://dx.doi.org/10.1111/tbed.13205DOI Listing

A Parsimonious Mechanism of Sugar Dehydration by Human GDP-Mannose-4,6-dehydratase.

ACS Catal 2019 Apr 1;9(4):2962-2968. Epub 2019 Mar 1.

Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, NAWI Graz, 8010 Graz, Austria.

Biosynthesis of 6-deoxy sugars, including l-fucose, involves a mechanistically complex, enzymatic 4,6-dehydration of hexose nucleotide precursors as the first committed step. Here, we determined pre- and postcatalytic complex structures of the human GDP-mannose 4,6-dehydratase at atomic resolution. These structures together with results of molecular dynamics simulation and biochemical characterization of wildtype and mutant enzymes reveal elusive mechanistic details of water elimination from GDP-mannose C5″ and C6″, coupled to NADP-mediated hydride transfer from C4″ to C6″. Read More

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http://pubs.acs.org/doi/10.1021/acscatal.9b00064
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http://dx.doi.org/10.1021/acscatal.9b00064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454399PMC
April 2019
1 Read

Changes Over a Decade in Anthropometry and Fitness of Elite Austrian Youth Soccer Players.

Front Physiol 2019 28;10:333. Epub 2019 Mar 28.

Department of Sport and Exercise Science, University of Salzburg, Salzburg, Austria.

Increases in physical (e.g., high-intensity running and sprinting), technical (e. Read More

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https://www.frontiersin.org/article/10.3389/fphys.2019.00333
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http://dx.doi.org/10.3389/fphys.2019.00333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447713PMC
March 2019
1 Read

High-dose intravenous versus oral iron in blood donors with iron deficiency: The IronWoMan randomized, controlled clinical trial.

Clin Nutr 2019 Mar 26. Epub 2019 Mar 26.

Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria; Thyroid Endocrinology Osteoporosis Institute Dobnig Graz, Jakob-Redtenbachergasse 10, 8010, Graz, Austria. Electronic address:

Introduction: Frequent blood donation often leads to iron deficiency and even anemia but appropriate strategies for detection and prevention are currently not mandatory. At the Medical University of Graz, we conducted a single-center prospective clinical trial to compare oral and IV iron supplementation in iron deficient blood donors including Austrian regular whole blood and platelet apheresis donors. We aimed to determine the difference of transferrin saturation between the treatment groups 8-12 weeks iron administration besides other parameters of iron status and blood count. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.03.025DOI Listing

[CGM-Continuous Glucose Monitoring-Statement of the Austrian Diabetes Association (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Abteilung für Innere Medizin, Privatklinik Wehrle-Diakonissen, Salzburg, Österreich.

This position statement represents the recommendations of the Austrian Diabetes Association regarding the clinical diagnostic and therapeutic application, safety and benefits of continuous subcutaneous glucose monitoring systems in patients with diabetes, based on current evidence. Read More

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http://link.springer.com/10.1007/s00508-019-1465-x
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http://dx.doi.org/10.1007/s00508-019-1465-xDOI Listing
April 2019
2 Reads

[Position statement: surgery and diabetes mellitus (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

1. Medizinische Abteilung für Diabetologie, Endokrinologie und Nephrologie, Krankenanstalt Rudolfstiftung, Wien, Österreich.

This position statement reflects the opinion of the Austrian Diabetes Association concerning the perioperative management of patients with diabetes mellitus based on the available scientific evidence. The paper covers necessary preoperative examinations from an internal/diabetological point of view as well as the perioperative metabolic control by means of oral antidiabetics and/or insulin therapy. Read More

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http://dx.doi.org/10.1007/s00508-019-1459-8DOI Listing

[Diagnosis and management of patients with diabetes and co-existing osteoporosis (Update 2019) : Common guideline of the Autrian Society for Bone and Mineral Research and the Austrian Diabetes Society].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Externe Lehre, Medizinische Universität Wien, Wien, Österreich.

Fragility fractures are increasingly recognized as a complication of both type 1 and type 2 diabetes, with fracture risk that increases with disease duration and poor glycemic control. The identification and management of fracture risk in these patients remains challenging. This manuscript explores the clinical characteristics of bone fragility in adults with diabetes and highlights recent studies that have evaluated areal bone mineral density (BMD), bone microstructure and material properties, biochemical markers, and fracture prediction algorithms (FRAX) in these patients. Read More

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http://dx.doi.org/10.1007/s00508-019-1462-0DOI Listing

[Lifestyle: physical activity and training as prevetion and therapy of type 2 diabetes mellitus (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Österreichische Gesellschaft für Public Health, Wien, Österreich.

Lifestyle in general and particularly health enhancing physical activity is known to be an important component in the prevention and therapy of type 2 diabetes mellitus.To gain substantial health benefits a minimum of 150 min of moderate or vigorous intense aerobic physical activity and muscle strengthening activities per week are needed. Additionally, inactivity should be recognised as health hazard and prolonged episodes of sitting should be avoided. Read More

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http://dx.doi.org/10.1007/s00508-019-1457-xDOI Listing

[Hospital diabetes management (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Klinische Abteilung für Endokrinologie und Diabetologie, Universitätsklinik für Innere Medizin, Medizinische Universität Graz, Auenbruggerplatz 15, 8036, Graz, Österreich.

This position statement presents the recommendations of the Austrian Diabetes Association for diabetes management of adult patients during inpatient stay. It is based on the current evidence with respect to blood glucose targets, insulin therapy and treatment with oral antidiabetic drugs during inpatient hospitalization. Additionally, special circumstances such as intravenous insulin therapy, concomitant therapy with glucocorticoids and use of diabetes technology during hospitalization are discussed. Read More

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http://link.springer.com/10.1007/s00508-019-1447-z
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http://dx.doi.org/10.1007/s00508-019-1447-zDOI Listing
April 2019
1 Read

[Diagnosis, treatment and monitoring of diabetic eye disease (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Universitäts-Augenklinik, Medizinische Universität Graz, Graz, Österreich.

Diabetes mellitus can cause diabetic retinopathy, diabetic macular edema, optic neuropathy, cataract or dysfunction of the eye muscles. The incidence of these defects correlates with disease duration and quality of metabolic control. Recommendations of the Austrian Diabetes Association for diagnosis, therapeutic procedures and requirements for adequate follow-up depending on stage of diabetic eye disease are summarized. Read More

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http://dx.doi.org/10.1007/s00508-019-1445-1DOI Listing

[Migration and diabetes (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

5. Medizinische Abteilung mit Endokrinologie, Rheumatologie und Akutgeriatrie, Wilhelminenspital der Stadt Wien, Montlearstraße 37, 1160, Wien, Österreich.

The article deals with the demographic data of migration in Austria and with therapeutic advice concerning drug therapy and diabetes education for patients with migration background. In this context sociocultural specifics are discussed. These suggestions are seen complementary to the general treatment guidelines of the Austrian Diabetes Association. Read More

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http://link.springer.com/10.1007/s00508-019-1446-0
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http://dx.doi.org/10.1007/s00508-019-1446-0DOI Listing
April 2019
1 Read

[Lipids-Diagnosis and therapy in diabetes mellitus (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Abteilung für Innere Medizin und Intensivmedizin, Krankenhaus der Barmherzigen Brüder Linz, Linz, Österreich.

Hyper- and dyslipidemia contribute to cardiovascular morbidity and mortality in diabetic patients. Pharmacological therapy to lower LDL cholesterol has convincingly shown to reduce cardiovascular risk in diabetic patients. The present article represents the recommendations of the Austrian Diabetes Association for the use of lipid-lowering drugs in diabetic patients according to current scientific evidence. Read More

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http://link.springer.com/10.1007/s00508-019-1444-2
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http://dx.doi.org/10.1007/s00508-019-1444-2DOI Listing
April 2019
2 Reads

[Inhibition of platelet aggregation (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Abteilung für Innere Medizin I, Akademisches Lehrkrankenhaus Feldkirch, Feldkirch, Österreich.

Acute thrombotic complications as a key feature of accelerated atherothrombotic disease typically precipitate cardiovascular events and therefore strongly contribute to cardiovascular morbidity and mortality in diabetic patients. Inhibition of platelet aggregation can reduce the risk for acute atherothrombosis. The present article represents the recommendations of the Austrian Diabetes Association for the use of antiplatelet drugs in diabetic patients according to current scientific evidence. Read More

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http://dx.doi.org/10.1007/s00508-018-1437-6DOI Listing

[Blood glucose self monitoring (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Klinische Abteilung für Endokrinologie und Stoffwechsel, Universitätsklinik für Innere Medizin III, Medizinische Universität Wien, Wien, Österreich.

Self monitoring of blood glucose contributes to the integrated management of diabetes mellitus. It, thus, should be available for all patients with diabetes mellitus. Self monitoring of blood glucose improves patients safety, quality of life and glucose control. Read More

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http://link.springer.com/10.1007/s00508-018-1436-7
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http://dx.doi.org/10.1007/s00508-018-1436-7DOI Listing
April 2019
1 Read

[Diabetes mellitus in childhood and adolescence (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Department für Pädiatrie 1, Medizinische Universität Innsbruck, Anichstraße 35, 6020, Innsbruck, Österreich.

In contrast to adults, type 1 diabetes mellitus (T1D) is the most frequent form of diabetes in childhood and adolescence (>95%). After diagnosis the management of children and adolescents with T1D should take place in highly specialized pediatric units experienced in pediatric diabetology and not in private practices. The lifelong substitution of insulin is the cornerstone of treatment whereby modalities need to be individually adapted for patient age and the family routine. Read More

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http://dx.doi.org/10.1007/s00508-018-1420-2DOI Listing

[Insulin pump therapy in children, adolescents and adults, guidelines (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Abteilung für Innere Medizin, Privatklinik Wehrle-Diakonissen, Salzburg, Österreich.

This position statement is based on current evidence available on the safety and benefits of continuous subcutaneous insulin infusion therapy (CSII, pump therapy) in diabetes with an emphasis on the effects of CSII on glycemic control, hypoglycaemia rates, occurrence of ketoacidosis, quality of life and the use of insulin pump therapy in pregnancy. The current article represents the recommendations of the Austrian Diabetes Association for the clinical praxis of insulin pump treatment in children, adolescents and adults. Read More

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http://dx.doi.org/10.1007/s00508-019-1485-6DOI Listing

[Diabetic kidney disease (Update 2019) : Position paper of the Austrian Diabetes Association and the Austrian Society for Nephrology].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Klinische Abteilung für Nephrologie, Universitätsklinik für Innere Medizin, Medizinische Universität Graz, Graz, Österreich.

Recent epidemiological investigations have shown that approximately 2-3% of all Austrians suffer from diabetes with renal involvement, i. e. 250,000 people in Austria are affected. Read More

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http://link.springer.com/10.1007/s00508-018-1425-x
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http://dx.doi.org/10.1007/s00508-018-1425-xDOI Listing
April 2019
3 Reads

[Individualising antihypertensive therapy in patients with diabetes. A guideline by the Austrian Diabetes Association (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

VIVIT Institut, Landeskrankenhaus Feldkirch, Feldkirch, Österreich.

Hypertension is one of the most important comorbidities of diabetes, contributing significantly to death and leads to macrovascular and microvascular complications. When assessing the medical priorities for patients with diabetes, treating hypertension should be a primary consideration. In the present review practical approaches to hypertension in diabetes, including individualized targets for preventing specific complications are discussed according to current studies and guidelines. Read More

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http://dx.doi.org/10.1007/s00508-019-1460-2DOI Listing

Managing nitrogen through cover crop species selection in the U.S. mid-Atlantic.

PLoS One 2019 12;14(4):e0215448. Epub 2019 Apr 12.

Department of Ecosystem Science and Management, The Pennsylvania State University, University Park, PA, United States of America.

Cover crops have the potential to be agricultural nitrogen (N) regulators that reduce leaching through soils and then deliver N to subsequent cash crops. Yet, regulating N in this way has proven difficult because the few cover crop species that are well-studied excel at either reducing N leaching or increasing N supply to cash crops, but they fail to excel at both simultaneously. We hypothesized that mixed species cover crop stands might balance the N fixing and N scavenging capabilities of individual species. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215448PLOS
April 2019
2 Reads

Flooding and hydrologic connectivity modulate community assembly in a dynamic river-floodplain ecosystem.

PLoS One 2019 12;14(4):e0213227. Epub 2019 Apr 12.

Austrian Science Fund FWF, Vienna, Austria.

Braided river floodplains are highly dynamic ecosystems, where aquatic communities are strongly regulated by the hydrologic regime. So far, however, understanding of how flow variation influences assembly mechanisms remains limited. We collected benthic chironomids and oligochaetes over a year across a lateral connectivity gradient in the semi-natural Tagliamento River (Italy). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213227PLOS

Cavity-Based 3D Cooling of a Levitated Nanoparticle via Coherent Scattering.

Phys Rev Lett 2019 Mar;122(12):123601

Photonics Laboratory, ETH Zürich, 8093 Zürich, Switzerland.

We experimentally realize cavity cooling of all three translational degrees of motion of a levitated nanoparticle in vacuum. The particle is trapped by a cavity-independent optical tweezer and coherently scatters tweezer light into the blue detuned cavity mode. For vacuum pressures around 10^{-5}  mbar, minimal temperatures along the cavity axis in the millikelvin regime are observed. Read More

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https://link.aps.org/doi/10.1103/PhysRevLett.122.123601
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http://dx.doi.org/10.1103/PhysRevLett.122.123601DOI Listing
March 2019
5 Reads

A Novel Caenorhabditis Elegans Proteinopathy Model Shows Changes in mRNA Translational Frameshifting During Aging.

Cell Physiol Biochem 2019 ;52(5):970-983

Department of Chemistry and Biochemistry, University of Hamburg, Hamburg, Germany,

Background/aims: Regulation of mRNA translation is central to protein homeostasis and is optimized for speed and accuracy. Spontaneous recoding events occur virtually at any codon but at very low frequency and are commonly assumed to increase as the cell ages.

Methods: Here, we leveraged the polyglutamine(polyQ)-frameshifting model of huntingtin exon 1 with CAG repeat length in the pathological range (Htt51Q), which undergoes enhanced non-programmed translational -1 frameshifting. Read More

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http://dx.doi.org/10.33594/000000067DOI Listing
January 2019
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Patient-Sharing Relations in the Treatment of Diabetes and Their Implications for Health Information Exchange: Claims-Based Analysis.

JMIR Med Inform 2019 Apr 12;7(2):e12172. Epub 2019 Apr 12.

Section for Clinical Biometrics, Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna, Austria.

Background: Health information exchange (HIE) among care providers who cooperate in the treatment of patients with diabetes mellitus (DM) has been rated as an important aspect of successful care. Patient-sharing relations among care providers permit inferences about corresponding information-sharing relations.

Objectives: This study aimed to obtain information for an effective HIE platform design to be used in DM care by analyzing patient-sharing relations among various types of care providers (ToCPs), such as hospitals, pharmacies, and different outpatient specialists, within a nationwide claims dataset of Austrian DM patients. Read More

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http://medinform.jmir.org/2019/2/e12172/
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http://dx.doi.org/10.2196/12172DOI Listing
April 2019
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Novel electrical transport properties of native Fe-Nb oxide layers leading to unilateral conductivity of a refractory metallic glass.

Heliyon 2019 Mar 29;5(3):e01424. Epub 2019 Mar 29.

WPI Advanced Institute for Materials Research, Tohoku University, Sendai, 980-8577, Japan.

Fe-based metallic glasses (also called amorphous alloys) are known to have high hardness and high wear resistance. Here we study and present a Fe-Nb amorphous material with an unusual type of electrical conductivity behavior. The electrical transport properties of Fe-Nb oxide layers were studied by measuring local current-voltage characteristics by the atomic-force microscopy technique. Read More

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http://dx.doi.org/10.1016/j.heliyon.2019.e01424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441843PMC

How to do a clinical trial? Recommendations from the aerobiological point of view.

World Allergy Organ J 2019 28;12(4):100020. Epub 2019 Mar 28.

Aerobiology and Pollen Information Research Unit, Department of Oto-Rhino-Laryngology, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.

Background: Allergy immunotherapy is still the only treatment of pollen allergy, providing a long-term effect. Clinical trials with pollen allergic patients are in need of validated, high quality pollen data and forecasts in order to grant comparability and to adhere to scientific standards. The aerobiological part of clinical trials remained hitherto not well defined, leaving the definition and use of pollen and forecast data more or less open. Read More

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http://dx.doi.org/10.1016/j.waojou.2019.100020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441751PMC

subsp. , subsp. nov. (Chlamydomonadales, Chlorophyta): re-examination of a snow alga from the High Tatra Mountains (Slovakia).

2018 Mar 26;18(1):1-18. Epub 2017 Sep 26.

Charles University, Faculty of Science, Department of Ecology, Viničná 7, CZ-128 44 Prague, Czech Republic.

Melting snow fields populated by aplanozygotes of the genus (Chlamydomonadales, Chlorophyta) are found in polar and alpine habitats. In the High Tatra Mountains (Slovakia), cells causing blooms of brownish-red snow designated as kol turned out to be genetically (18S, ITS1 and ITS2 rDNA, L) very closely related to (Chodat) Hoham et Mullet from the Austrian Alps. Therefore, is transferred into the latter taxon and reduced to a subspecies as subsp. Read More

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http://dx.doi.org/10.5507/fot.2017.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456015PMC

Functional capillary impairment in patients with ventricular assist devices.

Sci Rep 2019 Apr 11;9(1):5909. Epub 2019 Apr 11.

Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.

The implantation of continuous - flow ventricular assist devices (VAD) is suggested to evoke angiodysplasia contributing to adverse events such as gastrointestinal bleeding. We evaluated in vivo capillary density and glycocalyx dimensions to investigate possible systemic microvascular changes in patients with chronic heart failure and VAD support vs. standard medical treatment. Read More

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http://dx.doi.org/10.1038/s41598-019-42334-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459831PMC
April 2019
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Bacterial medium-chain 3-hydroxy fatty acid metabolites trigger immunity in plants.

Science 2019 04;364(6436):178-181

Chair of Phytopathology, TUM School of Life Sciences Weihenstephan, Technical University of Munich, 85354 Freising-Weihenstephan, Germany.

In plants, cell-surface immune receptors sense molecular non-self-signatures. Lipid A of Gram-negative bacterial lipopolysaccharide is considered such a non-self-signature. The receptor kinase LIPOOLIGOSACCHARIDE-SPECIFIC REDUCED ELICITATION (LORE) mediates plant immune responses to and but not enterobacterial lipid A or lipopolysaccharide preparations. Read More

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http://dx.doi.org/10.1126/science.aau1279DOI Listing
April 2019
8 Reads

Spheroid glioblastoma culture conditions as antigen source for dendritic cell-based immunotherapy: spheroid proteins are survival-relevant targets but can impair immunogenic interferon γ production.

Cytotherapy 2019 Apr 8. Epub 2019 Apr 8.

Activartis Biotech GmbH, Vienna, Austria.

Background: Glioblastoma is the most aggressive type of brain cancer. Dendritic cell (DC)-based immunotherapy against glioblastoma depends on the effectiveness of loaded antigens. Sphere-inducing culture conditions are being studied by many as a potential antigen source. Read More

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http://dx.doi.org/10.1016/j.jcyt.2019.03.002DOI Listing

Pericytes Favor Oligodendrocyte Fate Choice in Adult Neural Stem Cells.

Front Cell Neurosci 2019 27;13:85. Epub 2019 Mar 27.

Laboratory of Stem Cells and Neuroregeneration, Institute of Anatomy, Histology and Pathology, Faculty of Medicine, Universidad Austral de Chile, Valdivia, Chile.

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). Upon demyelination, oligodendrocyte progenitor cells (OPCs) are activated and they proliferate, migrate and differentiate into myelin-producing oligodendrocytes. Besides OPCs, neural stem cells (NSCs) may respond to demyelination and generate oligodendrocytes. Read More

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https://www.frontiersin.org/article/10.3389/fncel.2019.00085
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http://dx.doi.org/10.3389/fncel.2019.00085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446960PMC
March 2019
2 Reads