105,545 results match your criteria Australian and New Zealand Continence Journal [Journal]


Vertebral heart size in healthy Australian cattle dog.

Anat Histol Embryol 2019 Feb 17. Epub 2019 Feb 17.

Department of Veterinary Medicine, Agroveterinary Sciences Center, State University of Santa Catarina (CAV / UDESC), Lages, Brazil.

The vertebral heart score or size (VHS) measurement is routinely used to provide a more objective measurement of cardiomegaly in dogs. However, breed or body conformation can influence the VHS. To assess the specific VHS for the Australian Cattle Dog, left-to-right lateral, right-to-left lateral, dorsoventral and ventrodorsal thoracic radiographs from 20 individuals free from cardiac and pulmonary disease were obtained. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ahe.12434DOI Listing
February 2019

Iodine status of Indigenous and non-Indigenous young adults in the Top End, before and after mandatory fortification.

Med J Aust 2019 Feb 7;210(3):121-125. Epub 2018 Dec 7.

Food Standards Australia New Zealand, Canberra, ACT.

Objective: To assess the median urine iodine concentration (UIC) of young adults in the Top End of Northern Territory, before and after fortification of bread with iodised salt became mandatory.

Design, Setting: Analysis of cross-sectional data from two longitudinal studies, the Aboriginal Birth Cohort and the non-Indigenous Top End Cohort, pre- (Indigenous participants: 2006-2007; non-Indigenous participants: 2007-2009) and post-fortification (2013-15).

Participants: Indigenous and non-Indigenous Australian young adults (mean age: pre-fortification, 17. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5694/mja2.12031DOI Listing
February 2019

Exposures to e-cigarettes and their refills: calls to Australian Poisons Information Centres, 2009-2016.

Med J Aust 2019 Feb 12;210(3):126. Epub 2018 Nov 12.

Victorian Poisons Information Centre, Austin Health, Melbourne, VIC.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5694/mja2.12032DOI Listing
February 2019

The Australian Health Practitioner Regulation Agency does not require doctors to practise under the name that they are registered under.

Authors:
Martin Fletcher

Med J Aust 2019 Feb 9;210(3):144. Epub 2018 Dec 9.

Australian Health Practitioner Regulation Agency, Melbourne, VIC.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5694/mja2.12037DOI Listing
February 2019

The Australian Health Practitioner Regulation Agency does not require doctors to practise under the name that they are registered under.

Med J Aust 2019 Feb 9;210(3):144-144.e1. Epub 2018 Dec 9.

Community Forensic Mental Health Service, Victorian Institute of Forensic Mental Health, Melbourne, VIC.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5694/mja2.12038DOI Listing
February 2019

Patterns of high-risk prescribing and other factors in relation to receipt of a home medicines review: a prospective cohort investigation among adults aged 45 years and over in Australia.

BMJ Open 2019 Feb 15;9(2):e027305. Epub 2019 Feb 15.

Research School of Population Health, Australian National University, Canberra, Sydney, Australia.

Objectives: To quantify the relationship between home medicines review (HMR) receipt in older adults and sociodemographic, medication-related and health factors.

Design: Prospective cohort analysis.

Settings, Participants, Measurements: Questionnaire data from a population-based cohort study of individuals aged ≥45 years, Sydney, Australia were linked with primary healthcare data, medication and hospitalisation data, to ascertain factors associated with HMR receipt during the period July 2009-June 2014. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-027305DOI Listing
February 2019

Comparison of the EQ-5D 3L and the SF-6D (SF-36) contemporaneous utility scores in patients with chronic kidney disease in Sri Lanka: a cross-sectional survey.

BMJ Open 2019 Feb 15;9(2):e024854. Epub 2019 Feb 15.

Australian Centre for Health Services Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia.

Objectives: The aim of this study was to compare utility weights of EuroQoL-five-dimension-3 levels (EQ-5D-3L) and Short-Form six-dimension (SF-6D) in a representative cohort of patients with chronic kidney disease (CKD). A cost-utility analysis (CUA) is designed to report the change to costs required to achieve an estimated change to quality-adjusted life years (QALYs). The quality component of a QALY is measured by utility. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-024854DOI Listing
February 2019

Conversion of other opioids to methadone: a retrospective comparison of two methods.

BMJ Support Palliat Care 2019 Feb 16. Epub 2019 Feb 16.

Department of Supportive and Palliative Care, Mater Health Services, Brisbane, Queensland, Australia

Context: A rapid method of methadone conversion known as the Perth Protocol is commonly used in Australian palliative care units. There has been no follow-up or validation of this method and no comparison between different methods of conversion.

Objectives: The primary objective of this study was to test the hypothesis that the achieved doses of methadone are independent of the conversion method (rapid vs slower). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjspcare-2018-001645DOI Listing
February 2019

Does One Health require a novel ethical framework?

J Med Ethics 2019 Feb 16. Epub 2019 Feb 16.

Australian Centre for Health Engagement, Evidence and Values, University of Wollongong, Wollongong, New South Wales, Australia.

Emerging infectious diseases (EIDs) remain a significant and dynamic threat to the health of individuals and the well-being of communities across the globe. Over the last decade, in response to these threats, increasing scientific consensus has mobilised in support of a One Health (OH) approach so that OH is now widely regarded as the most effective way of addressing EID outbreaks and risks. Given the scientific focus on OH, there is growing interest in the philosophical and ethical dimensions of this approach, and a nascent OH literature is developing in the humanities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/medethics-2018-105043DOI Listing
February 2019

Implication of Ventricular Pacing Burden and Atrial Pacing Therapies on the Progression of Atrial Fibrillation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Heart Rhythm 2019 Feb 14. Epub 2019 Feb 14.

Centre for Heart Rhythm disorders (CHRD), South Australian Health and Medical Research Institute (SAHMRI), University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia. Electronic address:

Background: Atrial fibrillation (AF) is common after pacemaker implantation. Nevertheless, the impact of pacemaker algorithms in AF prevention is not well understood.

Objectives: To evaluate the role of pacing algorithms in preventing AF progression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hrthm.2019.02.020DOI Listing
February 2019

Evolutionary and Biogeographic History of the Black Fly Simulium wayani (Diptera: Simuliidae) on the Island of Timor.

Acta Trop 2019 Feb 14. Epub 2019 Feb 14.

Faculty of Mathematics and Natural Science, University of Mataram, Mataram, 83125, Indonesia. Electronic address:

A recently described species of black fly, Simulium wayani Takaoka and Chen, from the island of Timor was chromosomally mapped to provide insights into its evolutionary and biogeographic history. The morphologically based species status of S. wayani is supported by a suite of fixed chromosomal rearrangements and unique sex chromosomes derived primarily from a large pool of polymorphisms in the S. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.actatropica.2019.02.017DOI Listing
February 2019

Prostatic nerve subtypes independently predict biochemical recurrence in prostate cancer.

J Clin Neurosci 2019 Feb 13. Epub 2019 Feb 13.

Department of Surgery, Division of Urology, University of Melbourne, Royal Melbourne Hospital, Australia; Urology Unit, Department of Surgery, Peninsula Health, Australia; Australian Prostate Cancer Research Centre Epworth, Richmond, Australia.

Objective: To describe nerve subtypes involved by perineural invasion (PNI) in prostate cancer and their relationship with clinicopathological parameters and recurrence risk.

Methods: 141 prostatectomy specimens from men with localized prostate cancer and known perineural invasion were analyzed. Index tumor blocks were stained for perineural invasion and sympathetic/parasympathetic markers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jocn.2019.01.052DOI Listing
February 2019

Effect of concentric and eccentric hamstring training on sprint recovery, strength and muscle architecture in inexperienced athletes.

J Sci Med Sport 2019 Jan 26. Epub 2019 Jan 26.

School of Exercise and Nutrition Sciences, Queensland University of Technology, Australia.

Objectives: To investigate whether five-weeks of concentric (CON) or eccentric (ECC) hamstring strength training have different effects on recovery from sprint running, eccentric strength and architecture of the biceps femoris long head (BF).

Design: Cohort study.

Methods: Thirty males (age, 22. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jsams.2019.01.010DOI Listing
January 2019

Effect of pre-maturation with C-type natriuretic peptide and 3-isobutyl-1-methylxanthine on cumulus-oocyte communication and oocyte developmental competence in cattle.

Anim Reprod Sci 2019 Mar 25;202:49-57. Epub 2019 Jan 25.

Robinson Research Institute, School of Paediatrics and Reproductive Health, The University of Adelaide, Adelaide, South Australia, 5005, Australia; Adelaide Medical School, The University of Adelaide, Adelaide, South Australia, 5005, Australia; Australian Research Council Centre of Excellence for Nanoscale BioPhotonics and Institute for Photonics and Advanced Sensing, The University of Adelaide, Adelaide, South Australia, 5005, Australia. Electronic address:

In vitro embryo production depends on oocyte competence, which is acquired during folliculogenesis, involving cytoplasmic and nuclear processes. In vitro maturation (IVM) induces spontaneous resumption of meiosis, preventing full competence acquisition. The incorporation of a pre-IVM phase with supplementation with C-type natriuretic peptide (CNP) and 3-Isobutyl-1-methylxanthine (IBMX) was used with the aim of improving developmental competence of cattle oocytes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.anireprosci.2019.01.007DOI Listing

High sensitivity ammonia detection using metal nanoparticles decorated on graphene macroporous frameworks/polyaniline hybrid.

Talanta 2019 May 17;197:457-464. Epub 2019 Jan 17.

Malek-Ashtar University of Technology, P.O. Box 16765-3454, Tehran, Iran. Electronic address:

In this paper, we presented the fabrication and properties of new ammonia (NH) sensors with sensitive layer of nickel nanoparticles decorated on three-dimensional nitrogen-doped graphene-based frameworks/polyaniline (NiNPs@3D-(N)GFs/PANI) hybrid. The hybrid are synthesized through in-situ oxidative polymerization on flexible thin substrate. Synergetic behavior between both components manifested outstanding sensitivity (750. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.talanta.2019.01.060DOI Listing

Optimise not compromise: The importance of a multidisciplinary breast cancer patient pathway in the era of oncoplastic and reconstructive surgery.

Crit Rev Oncol Hematol 2019 Feb 30;134:10-21. Epub 2018 Nov 30.

Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia; Sydney Medical School, University of Sydney, New South Wales, Australia; Department of Radiation Oncology, Royal North Shore Hospital, St Leonards, New South Wales, Australia.

Modern breast cancer care is a complex multidisciplinary undertaking in which the integrated function of multiple constituent parts is critical, and where changes to one therapeutic component may profoundly influence the delivery and outcomes of another. Oncoplastic and reconstructive breast surgery has evolved in the era of longer survival rates for women with breast cancer and aims to enhance oncological and cosmetic outcomes. However, concurrently there has been an expansion in the indications for post-mastectomy radiation therapy (Abdulkarim et al. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.critrevonc.2018.11.007DOI Listing
February 2019

SELDI-TOF MS Analysis of Hepatocellular Carcinoma in an Australian Cohort.

J Surg Res 2019 Feb 13;238:127-136. Epub 2019 Feb 13.

Cancer Surgery and Metabolism Research Group, University of Sydney, Kolling Institute of Medical Research, St Leonards, NSW, Australia; Upper GI Surgical Unit, Royal North Shore Hospital and North Shore Private Hospital, St Leonards, NSW, Australia; Discipline of Surgery, The University of Sydney, Camperdown, NSW, Australia.

Background: Hepatocellular carcinoma (HCC) is a common cause of cancer death worldwide. Resection offers the best chance of long-term survival, but a consistent adverse prognostic factor is the presence of microvascular invasion (MVI). In this study, surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS), a high throughput method of analyzing complex samples, was used to explore differentially expressed proteins between HCC and adjacent nontumour liver tissue (ANLT). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jss.2019.01.008DOI Listing
February 2019

Exploring the experiences of early career academic nurses as they shape their career journey: A qualitative study.

Nurse Educ Today 2019 Feb 5;76:68-72. Epub 2019 Feb 5.

IMPACCT (Centre for Improving Palliative, Aged and Chronic Care through Clinical Research and Translation), University of Technology Sydney, Australia; Johns Hopkins University, Baltimore, MD, United States of America. Electronic address:

Objective: This study aimed to explore the experiences of early career academic nurses as they shape their career path in one Australian university.

Background: The early years of academic career development can be challenging as individuals learn to adjust to the teaching, research and service mission of universities. Tertiary institutions have an obligation to provide future nursing leaders with relevant and timely support during the formative phase of career development, to be successful in a competitive global environment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nedt.2019.01.021DOI Listing
February 2019

Molecular phylogenetics and species delimitation in annual species of Hydrocotyle (Araliaceae) from South Western Australia.

Authors:
Andrew J Perkins

Mol Phylogenet Evol 2019 Feb 13. Epub 2019 Feb 13.

Western Australian Herbarium, Biodiversity and Conservation Science, Department of Biodiversity, Conservation and Attractions, Locked Bag 104, Bentley Delivery Centre, Western Australia 6983. Electronic address:

Hydrocotyle L. is a cosmopolitan genus, with approximately 150 species, of mostly perennial herbs in the family Araliaceae. The genus includes around 115 perennial and 35 annual species, with all annual species endemic to Australia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ympev.2019.02.011DOI Listing
February 2019

A combined immunodeficiency with severe infections, inflammation and allergy caused by ARPC1B deficiency.

J Allergy Clin Immunol 2019 Feb 13. Epub 2019 Feb 13.

Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Department of Pediatric Immunology, Rheumatology and Infectious diseases, Meibergdreef 9, Amsterdam, The Netherlands; Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory AMC, University of Amsterdam, The Netherlands. Electronic address:

We report the natural history, clinical manifestations, genetics, and immunohematological findings in 14 patients from 11 families with ARPC1B deficiency, delineating the spectrum of the disease that appears progressive and challenging to manage clinically. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2019.02.003DOI Listing
February 2019

G Protein-Coupled Receptors are Dynamic Regulators of Digestion and Targets for Digestive Diseases.

Gastroenterology 2019 Feb 13. Epub 2019 Feb 13.

Monash Institute of Pharmaceutical Sciences, and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia; Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, VIC 3010, Australia; Columbia University College of Physicians and Surgeons, Columbia University in the City of New York, 21 Audubon Avenue, Rm 209, New York City, NY 10032, USA. Electronic address:

G protein-coupled receptors (GPCRs) are the largest family of transmembrane signaling proteins. Within the gastrointestinal tract, GPCRs expressed by epithelial cells sense contents of the lumen, and GPCRs expressed by epithelial cells, myocytes, neurons, and immune cells participate in communication amongst cells. GPCRs control digestion, mediate digestive diseases, and coordinate repair and growth. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2019.01.266DOI Listing
February 2019

Mortality after breast cancer as a function of time since diagnosis by estrogen receptor status and age at diagnosis.

Int J Cancer 2019 Feb 16. Epub 2019 Feb 16.

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, 207 Bouverie Street, Melbourne, Victoria 3010, Australia.

Our aim was to estimate how long-term mortality following breast cancer diagnosis depends on age at diagnosis, tumor estrogen receptor (ER) status, and the time already survived. We used the population-based Australian Breast Cancer Family Study which followed-up 1,196 women enrolled during 1992-99 when aged <60 years at diagnosis with a first primary invasive breast cancer, over-sampled for younger ages at diagnosis, for whom tumor pathology features and ER status were measured. There were 375 deaths (median follow-up=15. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/ijc.32214
Publisher Site
http://dx.doi.org/10.1002/ijc.32214DOI Listing
February 2019
3 Reads

Binding identity and orientation in object recognition.

Atten Percept Psychophys 2019 Feb 15. Epub 2019 Feb 15.

School of Psychology, University of Auckland, Auckland, New Zealand.

We tested whether an object's orientation is inherently bound to its identity in a holistic view-based representation at the early stages of visual identification, or whether identity and orientation are represented separately. Observers saw brief and masked stimulus sequences containing two rotated objects. They had to detect if a previously cued object was present in the sequence and report its orientation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3758/s13414-019-01677-9DOI Listing
February 2019

Evidence for personalised medicine: mechanisms, correlation, and new kinds of black box.

Theor Med Bioeth 2019 Feb 15. Epub 2019 Feb 15.

Macquarie University, North Ryde, NSW, Australia.

Personalised medicine (PM) has been discussed as a medical paradigm shift that will improve health while reducing inefficiency and waste. At the same time, it raises new practical, regulatory, and ethical challenges. In this paper, we examine PM strategies epistemologically in order to develop capacities to address these challenges, focusing on a recently proposed strategy for developing patient-specific models from induced pluripotent stem cells (iPSCs) so as to make individualised treatment predictions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11017-019-09482-zDOI Listing
February 2019

Cerebrospinal fluid biomarkers for understanding multiple aspects of Alzheimer's disease pathogenesis.

Cell Mol Life Sci 2019 Feb 15. Epub 2019 Feb 15.

Centre of Excellence in Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA, Australia.

Alzheimer's disease (AD) is a multifactorial age-related brain disease. Numerous pathological events run forth in the brain leading to AD. There is an initial long, dormant phase before the clinical symptoms become evident. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00018-019-03040-5DOI Listing
February 2019
1 Read

Comparative studies of catalytic pathways for Streptococcus pneumoniae sialidases NanA, NanB and NanC.

Sci Rep 2019 Feb 15;9(1):2157. Epub 2019 Feb 15.

School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW, 2500, Australia.

Streptococcus pneumoniae (S. pneumoniae) is a leading human pathogen, which takes large responsibility for severe otitis media, acute meningitis and septicaemia. It encodes up to three distinct sialidases: NanA, NanB and NanC, which are promising drug targets. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41598-018-38131-z
Publisher Site
http://dx.doi.org/10.1038/s41598-018-38131-zDOI Listing
February 2019
1 Read

Insluin and epithelial growth factor (EGF) promote programmed death ligand 1(PD-L1) production and transport in colon cancer stem cells.

BMC Cancer 2019 Feb 15;19(1):153. Epub 2019 Feb 15.

Australian Institute for Bioengineering and Nanotechnology (Building 75), The University of Queensland, Cooper Rd., St Lucia, Brisbane, QLD, 4072, Australia.

Background: Programmed cell death ligand 1 (PD-L1) is an important immune-inhibitory protein expressed on cancer cells to mediate cancer escape through interaction with PD-1 expressed on activated T lymphocytes (T cells). Previously, we reported that colon and breast cancer stem cells (CSCs) expressed much higher levels of PD-L1 than their parental cells, suggesting they will be more resistant to immune attack.

Methods: We investigated the underlining mechanism of PD-L1 increase in colon CSCs, with a special focus on the effect of insulin and epithelial growth factor (EGF), the two fundamental components to sustain the metabolism and stemness in the culture of CSCs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12885-019-5364-3DOI Listing
February 2019

Polygenic and sex specific architecture for two maturation traits in farmed Atlantic salmon.

BMC Genomics 2019 Feb 15;20(1):139. Epub 2019 Feb 15.

Commonwealth Scientific and Industrial Research Organisation Agriculture and Food, Queensland Bioscience Precinct, St Lucia Brisbane, 4067, Australia.

Background: A key developmental transformation in the life of all vertebrates is the transition to sexual maturity, whereby individuals are capable of reproducing for the first time. In the farming of Atlantic salmon, early maturation prior to harvest size has serious negative production impacts.

Results: We report genome wide association studies (GWAS) using fish measured for sexual maturation in freshwater or the marine environment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12864-019-5525-4DOI Listing
February 2019

Psychometric evaluation of social cognitive measures for adults with autism.

Autism Res 2019 Feb 15. Epub 2019 Feb 15.

School of Behavioral and Brain Sciences, The University Of Texas At Dallas, Richardson, Texas, 75080.

Although social cognition is frequently identified as a target in clinical trials and psychosocial interventions for adults with autism spectrum disorder (ASD), these efforts are hampered by a lack of consensus and validation of social cognitive measures. The current study provides psychometric evaluation of 11 frequently used measures encompassing different subdomains of social cognition. Adults with autism (N = 103) and typically developing controls (N = 95) completed 11 commonly used social cognitive tasks spanning the domains of emotion processing, social perception, and mentalizing/theory of mind. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/aur.2084DOI Listing
February 2019

Recent strategies to enhance the performance of polymer monoliths for analytical separations.

J Sep Sci 2019 Feb 15. Epub 2019 Feb 15.

Australian Centre for Research on Separation Science (ACROSS), School of Natural Sciences-Chemistry, University of Tasmania, Hobart, TAS, Australia.

This review summarizes recent development made in the incorporation of functional materials into organic polymer monoliths, together with new monolithic forms and formats, which enhance their application as supports and stationary phase materials for sample preparation and chromatographic separations. While polymer monoliths are well known supports for the separation of large molecules, recent development have been made to improve their features for the separation of small molecules. The selectivity and performance of organic polymer monoliths has been improved by the incorporation of different materials, such as metal-organic frameworks, covalent organic frameworks, or other types of nanostructured materials (carbon nanohorns, nanodiamonds, polyoxometalates, layered double hydroxides, or attapulgite). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201801126DOI Listing
February 2019

Rates and outcomes of total knee replacement for rheumatoid arthritis compared to osteoarthritis.

ANZ J Surg 2019 Feb 15. Epub 2019 Feb 15.

South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia.

Background: Total knee replacement (TKR) has been shown to perform differently in patients with rheumatoid arthritis (RA) when compared to osteoarthritis (OA). In this study, we compare the survivorship between these two groups and examine patient and prosthesis factors that impact the revision rate.

Methods: All RA and OA patients undergoing TKR in Australia from 1 September 1999 to 31 December 2016 were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ans.15035DOI Listing
February 2019

Magnetic solid phase extraction of benzoylurea insecticides in tea samples with Fe O -hyperbranched polyester magnetic composite as sorbent.

J Sep Sci 2019 Feb 15. Epub 2019 Feb 15.

Department of Applied Chemistry, College of Science, China Agricultural University,, Beijing, China.

In this work, a method for the analysis of benzoylurea insecticides, including hexaflumuron, flufenoxuron, lufenuron and chlorfluazuron, in tea samples by HPLC with Fe O - hyperbranched polyester nanocomposite as the adsorbent for magnetic solid-phase extraction was developed. The magnetic nanocomposite was prepared and characterized by infrared spectroscopy, vibrating sample magnetometry and scanning electron microscopy. The as-prepared nanocomposite was used as the sorbent for extraction and preconcentration of pesticide residues in tea samples. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201801159DOI Listing
February 2019

Patient Perspectives on DMARD Safety Concerns in Rheumatology Trials: Results from Inflammatory Arthritis Patient Focus Groups and OMERACT Attendees Discussion.

J Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

Department of Family Medicine, McGill University, Montreal, Canada. Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark. Canberra Rheumatology, Canberra, ACT, Australia College of Health and Medicine, Australian National University, Canberra, ACT, Australia; Centre for Kidney Research, The Children's Hospital at Westmead, Sydney, NSW, Australia. Patient Partners, Ingersoll, Canada. Division of Rheumatology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA. Division of Rheumatology, Department of Medicine, Hospital for Special Surgery, New York, NY, USA; Department Social Work Programs, Hospital for Special Surgery, New York, NY USA; Department Social Work Programs, Hospital for Special Surgery, New York, NY USA; Division of Rheumatology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA; Institute of Bone and Joint Research-Kolling Institute, University of Sydney; Rheumatology Department, Royal North Shore Hospital; Centre for Health Policy, School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia; Northern Health, Epping Victoria. Sydney Medical School, University of Sydney, Sydney, Australia; Institute of Bone and Joint Research, Kolling Institute, Northern Sydney Local Health District, St Leonards, NSW, Australia; Department of Rheumatology, Royal North Shore Hospital, Reserve Road, St Leonards, NSW, 2065, Australia. Clinical Investigator, Ottawa Hospital Research Institute, Ottawa Hospital, Ottawa, Ontario, Canada; Adjunct Professor, School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa; Professor of Biostatistics and Clinical Epidemiology; Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital; & Department of Rheumatology, Odense University Hospital, Denmark.Professor, Department of Medicine, McGill University, Montreal, Quebec, Canada Adjunct Professor, Division of Rheumatology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA. Address correspondence to Dr. Susan J. Bartlett. Email:

Objective: The OMERACT Safety Working Group is identifying core safety domains that matter most to rheumatic disease patients.

Methods: International focus groups were held with 39 inflammatory arthritis patients to identify DMARD experiences and concerns. Themes were identified by pragmatic thematic coding and discussed in small groups by meeting attendees. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3899/jrheum.181185DOI Listing
February 2019

OMERACT Filter 2.1: Elaboration of the Conceptual Framework for Outcome Measurement in Health Intervention Studies.

J Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

From the Department of Epidemiology and Biostatistics, Amsterdam UMC, Vrije Universiteit; Department of Medical Humanities, VU University Medical Centre/EMGO+ institute, Amsterdam, the Netherlands; Institute for Work & Health and Institute for Health Policy Management and Evaluation, University of Toronto, Toronto; Centre for Practice-Changing Research, Ottawa Hospital Research Institute; Cardiovascular Research Methods Centre, University of Ottawa Heart Institute; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario; McGill Centre for Outcomes Research and Evaluation, Montreal, Quebec, Canada; Division of Rheumatology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland; Medicine Service, VA Medical Center; Department of Medicine, School of Medicine, University of Alabama; Division of Epidemiology, School of Public Health, University of Alabama, Birmingham, Alabama; SDG LLC, Cambridge, Massachusetts; Division of Immunology/Rheumatology, Stanford University School of Medicine, Palo Alto, California, USA; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and UK National Institute for Health Research (NIHR) Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK; Hôpital Ambroise Paré, Rheumatology Department, Boulogne-Billancourt; INSERM U1173, Laboratoire d'Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint- Quentin University, Saint-Quentin en Yvelines; Sorbonne Université; Pitié Salpêtrière hospital, AP-HP, Rheumatology Department, Paris, France; Sydney Medical School, Institute of Bone and Joint Research; Department of Rheumatology, Royal North Shore Hospital, St Leonards, Australia. DEB, COB III, PGC, MAD, MPD, LG, LM, LS, JAS, VS, GAW, and PT are members of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 12 companies. PGC is funded in part by the NIHR Leeds Biomedical Research Centre. The views expressed in this article are those of the authors and not necessarily those of the UK National Health Service, the NIHR, or the Department of Health. JAS is supported by the resources and use of the facilities at the VA Medical Center at Birmingham, Alabama, USA. The views expressed in this article are those of the authors and do not necessarily reflect the position or policy of the Department of Veterans Affairs or the US government. LM is a principal investigator on the Australian Rheumatology Association Database, which has received armslength funding from Pfizer Australia, AbbVie Australia, Eli Lilly Australia, and Janssen Australia. M. Boers, MD, PhD, Professor of Clinical Epidemiology, Amsterdam UMC, Vrije Universiteit Amsterdam; D.E. Beaton, PhD, Senior Scientist, Institute for Work & Health, and Associate Professor, Institute Health Policy, Management and Evaluation, University of Toronto; B.J. Shea, PhD, Senior Scientist, Ottawa Hospital Research Institute, Clinical Epidemiology Program, and School of Epidemiology, Public Health and Preventive Medicine, Faculty of Medicine, University of Ottawa; L.J. Maxwell, PhD, University of Ottawa and Centre for Practice-Changing Research, Ottawa Hospital Research Institute; S.J. Bartlett, PhD, Professor of Medicine, McGill University, Centre for Outcomes Research and Evaluation, and Division of Rheumatology, Department of Medicine, Johns Hopkins University; C.O. Bingham III, MD, Division of Rheumatology, Department of Medicine, Johns Hopkins University; P.G. Conaghan, MBBS, PhD, FRACP, FRCP, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre; M.A. D'Agostino, MD, PhD, AP-HP, Professor of Rheumatology, Hôpital Ambroise Paré, Rheumatology Department, and INSERM U1173, Laboratoire d'Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University; M.P. de Wit, PhD, OMERACT Patient Research Partner, and Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; L. Gossec, MD, PhD, Sorbonne Universités, UPMC Univ Paris 06, and AP-HP, Pitié Salpêtrière Hospital, Department of Rheumatology; L. March, MBBS, PhD, Liggins Professor of Rheumatology and Musculoskeletal Epidemiology, Sydney Medical School, Institute of Bone and Joint Research, and Department of Rheumatology, Royal North Shore Hospital; J.A. Singh, MBBS, MPH, Professor of Medicine and Epidemiology, Department of Medicine at the School of Medicine, University of Alabama at Birmingham; L.S. Simon, MD, Co-Managing Director of SDG LLC; V. Strand, MD, Biopharmaceutical Consultant, Portola Valley, California, USA; G.A. Wells, MSc, PhD, Director, Cardiovascular Research Methods Centre, University of Ottawa Heart Institute, and Professor, Department of Epidemiology and Community Medicine, University of Ottawa; P. Tugwell, MD, MSc, Professor, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute. Address correspondence to Dr. M. Boers, Department of Epidemiology and Biostatistics, Amsterdam UMC, Vrije Universiteit Amsterdam, the Netherlands. Accepted for publication December 6, 2018.

Objective: The Outcome Measures in Rheumatology (OMERACT) Filter 2.0 framework was developed in 2014 to aid core outcome set development by describing the full universe of "measurable aspects of health conditions" from which core domains can be selected. This paper provides elaborations and updated concepts (OMERACT Filter 2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3899/jrheum.181096DOI Listing
February 2019

Core Domain Set Selection According to OMERACT Filter 2.1: The OMERACT Methodology.

J Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

From the Centre for Practice-Changing Research, Ottawa Hospital Research Institute; Ottawa Hospital Research Institute, Clinical Epidemiology Program; School of Epidemiology, Public Health and Preventive Medicine, Faculty of Medicine, University of Ottawa; Cardiovascular Research Methods Centre, University of Ottawa Heart Institute; Department of Epidemiology and Community Medicine, University of Ottawa; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa; Institute for Work & Health; Institute Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada; Clinical Epidemiology, Amsterdam UMC, Vrije Universiteit Amsterdam; Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health, Amsterdam, the Netherlands; Division of Rheumatology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland; Medicine and Epidemiology, Department of Medicine at the School of Medicine, University of Alabama, Birmingham, Alabama; SDG LLC, Cambridge, Massachusetts; Division of Immunology/Rheumatology, Stanford University School of Medicine, Palo Alto, California, USA; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; UK National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds, UK; Hôpital Ambroise Paré, Rheumatology Department, Boulogne-Billancourt; INSERM U1173, Laboratoire d'Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University, Saint-Quentin en Yvelines; Sorbonne Universités, UPMC Univ Paris 06; AP-HP, Pitié Salpêtrière Hospital, Department of Rheumatology, Paris, France; Rheumatology and Musculoskeletal Epidemiology, Sydney Medical School, Institute of Bone and Joint Research; Department of Rheumatology, Royal North Shore Hospital, St Leonards, Australia. PGC is funded in part by the NIHR Leeds Biomedical Research Centre. The views expressed in this article are those of the authors and not necessarily those of the UK National Health Service, the NIHR, or the Department of Health. JAS is supported by the resources and the use of facilities at the VA Medical Center at Birmingham, Alabama. LM is a Principal Investigator on the Australian Rheumatology Association Database, which has received arms-length funding from Pfizer Australia, AbbVie Australia, Eli Lilly Australia, and Janssen Australia. The views expressed in this article are those of the authors and do not necessarily reflect the position or policy of the US Department of Veterans Affairs or the US government. L.J. Maxwell, PhD, University of Ottawa and Centre for Practice- Changing Research, Ottawa Hospital Research Institute; B.J. Shea, PhD, Clinical Investigator, Ottawa Hospital Research Institute, Clinical Epidemiology Program, and School of Epidemiology, Public Health and Preventive Medicine, Faculty of Medicine, University of Ottawa; D.E. Beaton, PhD, Senior Scientist, Institute for Work & Health, and Associate Professor, Institute Health Policy, Management and Evaluation, University of Toronto; G.A. Wells, MSc, PhD, Director, Cardiovascular Research Methods Centre, University of Ottawa Heart Institute, and Professor, Department of Epidemiology and Community Medicine, University of Ottawa; M. Boers, MD, PhD, Professor of Clinical Epidemiology, Amsterdam UMC, Vrije Universiteit Amsterdam; S. Grosskleg, OMERACT Secretariat, University of Ottawa; C.O. Bingham III, MD, Division of Rheumatology, Department of Medicine, Johns Hopkins University; P.G. Conaghan, MD, PhD, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Biomedical Research Centre; M.A. D'Agostino, MD, PhD, AP-HP, Professor of Rheumatology, Hôpital Ambroise Paré, Rheumatology Department, and INSERM U1173, Laboratoire d'Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University; M. de Wit, PhD, OMERACT Patient Research Partner, and Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; L. Gossec, MD, PhD, Professor of Rheumatology, Sorbonne Universités, UPMC Univ Paris 06, and AP-HP, Pitié Salpêtrière Hospital, Department of Rheumatology; L. March, MBBS, PhD, Liggins Professor of Rheumatology and Musculoskeletal Epidemiology, Sydney Medical School, Institute of Bone and Joint Research and Department of Rheumatology, Royal North Shore Hospital; J.A. Singh, MBBS, MPH, Professor of Medicine and Epidemiology, Department of Medicine at the School of Medicine, University of Alabama; L.S. Simon, MD, Co- Managing Director of SDG LLC; V. Strand, Biopharmaceutical Consultant, Portola Valley, California, USA; P. Tugwell, MD, MSc, Professor, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute. Address correspondence to L.J. Maxwell, Centre for Practice-Changing Research, Ottawa Hospital General Campus, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada. E-mail: Accepted for publication December 19, 2018.

Objective: To describe the Outcome Measures in Rheumatology (OMERACT) Filter 2.1 methodology for core domain set selection.

Methods: The "OMERACT Way for Core Domain Set selection" framework consists of 3 stages: first, generating candidate domains through literature reviews and qualitative work, then a process of consensus to obtain agreement from those involved, and finally formal voting on the OMERACT Onion. Read More

View Article

Download full-text PDF

Source
http://www.jrheum.org/lookup/doi/10.3899/jrheum.181097
Publisher Site
http://dx.doi.org/10.3899/jrheum.181097DOI Listing
February 2019
3 Reads

The underacknowledged PPA-ALS: A unique clinicopathologic subtype with strong heritability.

Neurology 2019 Feb 15. Epub 2019 Feb 15.

From the Brain and Mind Centre and Central Clinical School (R.H.T., B.G., C.D.-S., J.B.J.K., M.C.K., J.R.H., G.M.H.) and School of Medical Sciences (J.J.K.), Faculty of Medicine and Health, and Brain and Mind Centre and School of Psychology (O.P.), The University of Sydney; School of Medical Sciences (R.H.T., C.D.-S., G.M.H.), University of New South Wales & Neuroscience Research Australia; Department of Neurology (M.C.K.), Royal Prince Alfred Hospital; ARC Centre of Excellence in Cognition and its Disorders (J.R.H., O.P.); and Division of Neuroscience (B.G.), Garvan Institute of Medical Research and St Vincent's Clinical School, UNSW Sydney, New South Wales, Australia.

Objective: To assess the incidence, heritability, and neuropathology of primary progressive aphasia (PPA) with amyotrophic lateral sclerosis (ALS) in a large Australian cohort.

Methods: A total of 130 patients with a primary nonfluent variant of PPA (nfvPPA) or semantic variant of PPA (svPPA) were assessed for concomitant ALS and a strong family history of neurodegenerative diseases (Goldman score ≤3). Neuropathologic examination was carried out in 28% (n = 36) of these PPA and PPA-ALS cases that had come to autopsy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000007146DOI Listing
February 2019

Stereotactic ablative radiotherapy versus standard radiotherapy in stage 1 non-small-cell lung cancer (TROG 09.02 CHISEL): a phase 3, open-label, randomised controlled trial.

Lancet Oncol 2019 Feb 12. Epub 2019 Feb 12.

Peter MacCallum Cancer Centre, Melbourne, VIC, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia.

Background: Stereotactic ablative body radiotherapy (SABR) is widely used to treat inoperable stage 1 non-small-cell lung cancer (NSCLC), despite the absence of prospective evidence that this type of treatment improves local control or prolongs overall survival compared with standard radiotherapy. We aimed to compare the two treatment techniques.

Methods: We did this multicentre, phase 3, randomised, controlled trial in 11 hospitals in Australia and three hospitals in New Zealand. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1470-2045(18)30896-9DOI Listing
February 2019

An audit of propofol administration in the intensive care unit: Infusion pump-recorded versus electronically documented amounts.

Aust Crit Care 2019 Feb 12. Epub 2019 Feb 12.

Departments of Anaesthesia and Intensive Care, Western Health, Melbourne, Australia; Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia. Electronic address:

Background: Although propofol is widely used for sedation in intensive care units around Australia, evaluation of bedside nursing practices of the administration of propofol have been limited. We investigated whether there was a discrepancy between the amount of propofol delivered by the infusion pump and that recorded electronically and consequently patient exposure to avoidable harms.

Aims: The aim of this research was to compare the total amount of propofol administered to intensive care patients via a programmable infusion pump with that documented in the electronic medical record (EMR). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.aucc.2018.12.005DOI Listing
February 2019

Baseline parameters for rotational thromboelastometry (ROTEM®) in healthy women undergoing elective caesarean delivery: a prospective observational study in Australia.

Int J Obstet Anesth 2019 Jan 16. Epub 2019 Jan 16.

Department of Anaesthesia and Perioperative Services, The Royal Brisbane and Women's Hospital, QLD, Australia; The University of Queensland, Brisbane, QLD, Australia.

Background: Formal reference ranges for rotational thromboelastometry (ROTEM®) in pregnancy have not been obtained in the recommended minimum sample size of 120. This prospective observational study aimed to establish baseline parameters in an Australian population of women undergoing elective caesarean delivery. The secondary aim was to compare these reference ranges with those from prior studies and the manufacturer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijoa.2019.01.008DOI Listing
January 2019

Insulin resistance and insulin hypersecretion in the metabolic syndrome and type 2 diabetes: Time for a conceptual framework shift.

Diab Vasc Dis Res 2019 Feb 15:1479164119827611. Epub 2019 Feb 15.

3 CRCHUM and Montreal Diabetes Research Center, University of Montreal, Montreal, QC, Canada.

While few dispute the existence of the metabolic syndrome as a clustering of factors indicative of poor metabolic health, its utility above that of its individual components in the clinical care of individual patients is questioned. This is likely a consequence of the failure of clinicians and scientists to agree on a unifying mechanism to explain the metabolic syndrome. Insulin resistance has most commonly been proposed for this role and is generally considered to be a root causative factor for not only metabolic syndrome but also for its associated conditions of non-alcoholic fatty liver disease (NAFLD), polycystic ovary syndrome (PCOS), obesity-related type 2 diabetes (T2D) and atherosclerotic cardiovascular disease (ASCVD). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1479164119827611DOI Listing
February 2019

No Causal Effect of Telomere Length on Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study.

Cells 2019 Feb 14;8(2). Epub 2019 Feb 14.

Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing 100069, China.

Background: Epidemiological studies observing inconsistent associations of telomere length (TL) with ischemic stroke (IS) are susceptible to bias according to reverse causation and residual confounding. We aimed to assess the causal association between TL, IS, and the subtypes of IS, including large artery stroke (LAS), small vessel stroke (SVS), and cardioembolic stroke (CES) by performing a series of two-sample Mendelian randomization (MR) approaches.

Methods: Seven single nucleotide polymorphisms (SNPs) were involved as candidate instrumental variables (IVs), summarized from a genome-wide meta-analysis including 37,684 participants of European descent. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cells8020159DOI Listing
February 2019

Stem Cell-Derived Extracellular Vesicles for Treating Joint Injury and Osteoarthritis.

Nanomaterials (Basel) 2019 Feb 14;9(2). Epub 2019 Feb 14.

Raymond Purves Bone and Joint Research Laboratories, Institute of Bone and Joint Research, Kolling Institute, Northern Sydney Local Health District, Faculty of Medicine and Health, University of Sydney, St Leonards, NSW 2065, Australia.

Extracellular vesicles (EVs) are nanoscale particles secreted by almost all cell types to facilitate intercellular communication. Stem cell-derived EVs theoretically have the same biological functions as stem cells, but offer the advantages of small size, low immunogenicity, and removal of issues such as low cell survival and unpredictable long-term behaviour associated with direct cell transplantation. They have been an area of intense interest in regenerative medicine, due to the potential to harness their anti-inflammatory and pro-regenerative effects to induce healing in a wide variety of tissues. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/nano9020261DOI Listing
February 2019

Deposition of Stainless Steel Thin Films: An Electron Beam Physical Vapour Deposition Approach.

Materials (Basel) 2019 Feb 14;12(4). Epub 2019 Feb 14.

Imperial College London, Department of Chemical Engineering, SW72AZ London, UK.

This study demonstrates an electron beam physical vapour deposition approach as an alternative stainless steel thin films fabrication method with controlled layer thickness and uniform particles distribution capability. The films were fabricated at a range of starting electron beam power percentages of 3⁻10%, and thickness of 50⁻150 nm. Surface topography and wettability analysis of the samples were investigated to observe the changes in surface microstructure and the contact angle behaviour of 20 °C to 60 °C deionised waters, of pH 4, pH 7, and pH 9, with the as-prepared surfaces. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ma12040571DOI Listing
February 2019

Cytotoxicity of organic and inorganic compounds to primary cell cultures established from internal tissues of Chelonia mydas.

Sci Total Environ 2019 Feb 4;664:958-967. Epub 2019 Feb 4.

Australian Rivers Institute, School of Environment and Science, Griffith University, Gold Coast, Australia.

Chemical contaminants have been found in the tissues of sea turtles from all over the world; however, very little is known about the effects. Recently, in vitro alternatives to live animal testing have been applied to sea turtles due to their ethical and practical benefits. While primary skin fibroblasts have been established for several species of sea turtle, cells from internal organs are lacking, though they may be more relevant due to the well documented accumulation of contaminants within internal tissues. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2019.02.052DOI Listing
February 2019

Occurrence of disinfection by-products in swimming pools and the estimated resulting cytotoxicity.

Sci Total Environ 2019 Feb 2;664:851-864. Epub 2019 Feb 2.

Curtin Water Quality Research Centre (CWQRC), Chemistry, School of Molecular and Life Sciences, Curtin University, Perth, WA, Australia. Electronic address:

Swimming pools are disinfected to protect against the risk of microbial disease, however, the formation of disinfection by-products (DBPs) is an unwanted consequence. While many studies have reported the occurrence of commonly investigated DBPs (trihalomethanes and haloacetic acids) in pools, few studies have investigated emerging DBP classes, such as the haloketones or haloacetaldehydes, and the nitrogenous haloacetamides, halonitromethanes, haloacetonitriles and N-nitrosamines. This study investigated the occurrence of sixty four DBPs from the eight aforementioned DBP classes in pools employing different treatment methods. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2019.01.428DOI Listing
February 2019

Spatial and temporal dynamics of nutrients in riparian soils after nine years of operation of the Three Gorges Reservoir, China.

Sci Total Environ 2019 Feb 4;664:841-850. Epub 2019 Feb 4.

Key Laboratory of Aquatic Botany and Watershed Ecology, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan 430074, China. Electronic address:

The construction and operation of the Three Gorges Reservoir (TGR), the largest hydropower dam in the world, has had significant consequences for the hydrology of riparian zones along the Yangtze river. Little is known about how such changes in hydrology might affect the levels of nutrients and organic matter (OM) in riparian soils. We conducted a nine-year study on the spatio-temporal dynamics and dominant environmental correlates of nutrients and OM in riparian soils along a 600 km section of the Yangtze. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00489697193051
Publisher Site
http://dx.doi.org/10.1016/j.scitotenv.2019.02.036DOI Listing
February 2019
1 Read

Towards the development of standardised sea turtle primary cell cultures for toxicity testing.

Ecotoxicol Environ Saf 2019 Feb 12;173:63-70. Epub 2019 Feb 12.

Australian Rivers Institute, School of Environment and Science, Griffith University, Gold Coast, Australia.

Chemical contaminants are known to accumulate in marine megafauna globally, but little is known about how this impacts animal health. In vitro assays offer an ethical, reproducible and cost-effective alternative to live animal toxicity testing on large, long-lived or threatened species, such as sea turtles. However, using a cell culture from a single animal raise the question of whether the toxicity observed adequately represents the toxicity in that species. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ecoenv.2019.01.117DOI Listing
February 2019

Infant removals: The need to address the over-representation of Aboriginal infants and community concerns of another 'stolen generation'.

Child Abuse Negl 2019 Feb 12;90:88-98. Epub 2019 Feb 12.

Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia.

Objectives: The removal of a child from their parents is traumatising, particularly in Aboriginal communities where a history of child removals has led to intergenerational trauma. This study will determine where disparities in child protection involvement exist among Aboriginal and non-Aboriginal children and characteristics associated with infant removals. Challenges faced by child protection and other agencies, and opportunities for overcoming these, are discussed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chiabu.2019.01.017DOI Listing
February 2019

Retinal capillary perfusion: Spatial and temporal heterogeneity.

Prog Retin Eye Res 2019 Feb 12. Epub 2019 Feb 12.

Centre for Ophthalmology and Visual Science, The University of Western Australia, Perth, Australia; Lions Eye Institute, The University of Western Australia, Perth, Australia.

The central role of the cardiovascular system is to maintain adequate capillary perfusion. The spatially and temporally heterogeneous nature of capillary perfusion has been reported in some organs. However, such heterogeneous perfusion properties have not been sufficiently explored in the retina. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.preteyeres.2019.01.001DOI Listing
February 2019

Association between commercial funding of Canadian patient groups and their views about funding of medicines: An observational study.

Authors:
Joel Lexchin

PLoS One 2019 15;14(2):e0212399. Epub 2019 Feb 15.

School of Health Policy and Management, York University, Toronto, ON, Canada.

Background: Patient groups represent the interest of their members when it comes to drug funding. Many patient groups receive grants from pharmaceutical companies that make products being considered for funding. This research examines whether there is an association between the positions that Canadian groups take about the products and conflicts of interest with the companies. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212399PLOS
February 2019