20 results match your criteria Australian Journal Of Chemistry[Journal]

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Synthetic Models for Nickel-Iron Hydrogenase Featuring Redox-Active Ligands.

Aust J Chem 2017 May 11;70(5):505-515. Epub 2017 Jan 11.

Department of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Goodwin Ave., Urbana, IL 61801, USA.

The nickel-iron hydrogenase enzymes efficiently and reversibly interconvert protons, electrons, and dihydrogen. These redox proteins feature iron-sulfur clusters that relay electrons to and from their active sites. Reported here are synthetic models for nickel-iron hydrogenase featuring redox-active auxiliaries that mimic the iron-sulfur cofactors. Read More

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http://dx.doi.org/10.1071/CH16614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555595PMC
May 2017
7 Reads

Total Solid-Phase Synthesis of Biologically Active Drosophila Insulin-Like Peptide 2 (DILP2).

Aust J Chem 2017 12;70(2):208-212. Epub 2016 Dec 12.

Florey Institute of Neuroscience and Mental Health, University of Melbourne, Victoria 3010, Australia.

In the fruit fly , there are eight insulin-like peptides (DILPs) with DILPs 1-7 interacting with a sole insulin-like receptor tyrosine kinase (DInR) while DILP8 interacts with a single G protein-coupled receptor (GPCR), Lgr3. Loss-of-function mutation studies show that the neuropeptide DILP2 has a key role in carbohydrate and lipid metabolism as well as longevity and reproduction. A better understanding of the processes whereby DILP2 mediates its specific actions is required. Read More

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http://www.publish.csiro.au/?paper=CH16626
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http://dx.doi.org/10.1071/CH16626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826605PMC
December 2016
10 Reads

Thienyl Difluoroboron β-Diketonates in Solution and Polylactide Media.

Aust J Chem 2016 7;69(5):537-545. Epub 2016 Mar 7.

Department of Chemistry, University of Virginia, McCormick Road, Charlottesville, VA 22904.

Difluoroboron β-diketonates have impressive optical properties in both solution and the solid state. In particular, both fluorescence and room-temperature phosphorescence are present when the dyes are confined to a rigid matrix, such as poly(lactic acid) (PLA). To expand current knowledge and color range capabilities of this unique type of multi-emitting chromophore, a series of thienyl-substituted BFbdk complexes have been synthesized. Read More

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http://dx.doi.org/10.1071/CH15750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098477PMC
March 2016
10 Reads

: Thinking outside "the box".

Aust J Chem 2015 Sep 28;68(9):1319-1328. Epub 2015 Aug 28.

Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, 55 Fruit St., Boston, MA, 02114, USA.

The logic of total synthesis transformed a stagnant state of medicinal and synthetic organic chemistry when there was a paucity of methods and reagents to synthesize drug molecules and/or natural products. Molecular imaging by positron emission tomography (PET) is now experiencing a renaissance in the way radiopharmaceuticals for molecular imaging are synthesized, however, a paradigm shift is desperately needed in the discovery pipeline to accelerate in vivo imaging studies. A significant challenge in radiochemistry is the limited choice of labeled reagents (or building blocks) available for the synthesis of novel radiopharmaceuticals with the most commonly used short-lived radionuclides carbon-11 (C; half-life ~20 minutes) and fluorine-18 (F; half-life ~2 hours). Read More

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http://www.publish.csiro.au/?paper=CH15406
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http://dx.doi.org/10.1071/CH15406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976501PMC
September 2015
4 Reads

On the Mechanism of Berberine-INF55 (5-Nitro-2-phenylindole) Hybrid Antibacterials.

Aust J Chem 2015;67:1471-1480

School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia.

Berberine-INF55 hybrids are a promising class of antibacterials that combine berberine and the NorA multidrug resistance pump inhibitor INF55 (5-nitro-2-phenylindole) together in one molecule via a chemically stable linkage. Previous studies demonstrated the potential of these compounds for countering efflux-mediated antibacterial drug resistance but they didn't establish whether the compounds function as originally intended, i.e. Read More

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http://dx.doi.org/10.1071/CH14426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720975PMC
January 2015
6 Reads
3 Citations
1.560 Impact Factor

Photoinduced Cycloadditions in the Diversity-Oriented Synthesis Toolbox: Increasing Complexity with Straightforward Postphotochemical Modifications.

Aust J Chem 2015 24;68(11):1672-1681. Epub 2015 Jul 24.

Department of Chemistry and Biochemistry, University of Denver, Denver, CO 80208.

Rapid growth of complexity and unprecedented molecular architectures are realized via the excited-state intramolecular proton transfer (ESIPT) in -acylamidobenzaldehydes and ketones followed by [4+2] or [4+4] cycloadditions with subsequent postphotochemical modifications. The approach is congruent with Diversity-Oriented Synthesis: photoprecursors are synthesized in a modular fashion allowing for up to four diversity inputs. The complexity of the primary photoproducts is further enhanced using straightforward and high-yielding postphotochemical modification steps such as reactions with nitrile oxides, nitrones, Povarov reaction, and oxa-Diels-Alder reaction. Read More

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http://dx.doi.org/10.1071/CH15266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731653PMC
July 2015
1 Read

Molecular Characterization of Collagen Hydroxylysine -Glycosylation by Mass Spectrometry: Current Status.

Aust J Chem 2013 Jul;66(7):760-769

Mass Spectrometry Group, National Institutes of Health/National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, NC 27709, USA.

The most abundant proteins in vertebrates - the collagen family proteins - play structural and biological roles in the body. The predominant member, type I collagen, provides tissues and organs with structure and connectivity. This protein has several unique post-translational modifications that take place intra- and extra-cellularly. Read More

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http://dx.doi.org/10.1071/CH13174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235766PMC

Progress Towards Simple and Direct Detection of Adenylosuccinate Lyase Deficiency in Human Urine.

Aust J Chem 2011 Oct;64(11):1470-1473

Department of Chemistry, Portland State University, Portland, Oregon 97207, USA.

A rhodamine based boronic acid linearly responds to increasing 5-aminoimidazole-4-carboxamide riboside (AICAr) concentrations in human urine. This method is thus an advance in detecting adenylosuccinate lyase (ADSL) deficiency as AICAr is a model riboside for the ADSL substrates succinyladenosine (S-Ado) and succinylaminoimidazolecarboxamide riboside (SAICAr). ADSL deficiency is a rare but devastating disease of de novo purine synthesis in infants. Read More

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http://dx.doi.org/10.1071/CH11328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377351PMC
October 2011
1 Read

N-Heterocyclic Carbene-Promoted Rauhut]Currier Reactions between Vinyl Sulfones and α,β-Unsaturated Aldehydes.

Aust J Chem 2011 Aug;64(8):1158-1164

Department of Chemistry, Center for Molecular Innovation and Drug Discovery, Chemistry of Life Processes Institute, Silverman Hall, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA.

N-heterocyclic carbenes (NHCs) promote the addition of 1,1-bis(phenylsulfonyl)ethylene to the α-position of α,β-unsaturated aldehydes. The proposed reaction pathway for this Rauhut-Currier-type reaction includes an unusual conjugate addition of an NHC to a bis-vinyl sulfone. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293187PMC
August 2011
1 Read

Synthesis and Pharmacological Evaluation of 4-Iminothiazolidinones for Inhibition of PI3 Kinase.

Aust J Chem 2012 Jan;65(10):1396-1404

Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, Vic. 3052, Australia.

The thiazolidinedione, compound , has previously shown pan-inhibition of the phosphoinositide 3-kinase (PI3K) class I isoforms. We hypothesized the derivatization of the thiazolidinedione core of compound could introduce isoform selectivity. We report the synthesis, characterization, and inhibitory activity of a novel series of 4-iminothiazolidin-2-ones for inhibition of the class I PI3K isoforms. Read More

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http://dx.doi.org/10.1071/CH12140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755381PMC
January 2012
4 Reads

Chemically Specific Imaging Through Stimulated Raman Photoexcitation and Ultrasound Detection: Minireview.

Aust J Chem 2012 Jan;65(3):260-265

Department of Physics, University of Wisconsin - Milwaukee, Milwaukee, WI 53211, USA. ; Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843, USA.

A powerful combination of chemically specific Raman excitation and deep tissue ultrasound imaging holds the promise to attain spatially resolved distribution of chemical compounds inside the scattering medium. In this report, an attempt is made to evaluate the recent achievements and possible challenges with an eye on potential clinical applications. Read More

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http://dx.doi.org/10.1071/CH11407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691871PMC
January 2012
5 Reads

Photocatalytic Water Oxidation Using Manganese Compounds Immobilized in Nafion Polymer Membranes.

Aust J Chem 2011 Sep;64(9):1221-1228

Department of Chemistry, Yale University, New Haven, CT 06520, USA.

Robust water oxidation catalysts using earth abundant metals are required as part of an overall scheme to convert sunlight into fuels. Here, we report the immobilization of [[Formula: see text]O(5)(terpy)(4)(H(2)O)(2)](ClO(4))(6) (terpy = 2,2';6',2″-terpyridine), [Mn(4)O(6)(tacn)(4)](ClO(4))(4) (tacn = 1,4,7-triazacyclononane), and manganese dioxide nanoparticles in Nafion on fluorine-doped tin oxide conducting glass electrodes. The electrodes are illuminated with white light in the presence of an applied potential and the resulting photocurrent is assigned to the oxidation of solvent water. Read More

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http://dx.doi.org/10.1071/CH11178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227032PMC
September 2011
1 Read

NHC-Based Self-Assembled Monolayers on Solid Gold Substrates.

Aust J Chem 2011 Aug;64(8):1177-1179

National ESCA and Surface Analysis Center for Biomedical Problems (NESAC/BIO), Departments of Bioengineering and Chemical Engineering, University of Washington, Seattle, Washington 98195, USA.

Thin films of 1,3-diethylbenzimidazol-2-ylidene (BIEt) were fabricated from THF solution on solid gold substrates and characterised by high-resolution X-ray photoelectron and near-edge X-ray absorption fine structure spectroscopy. The surface-analytical data are in accord with the formation of self-assembled monolayers of BIEt molecules exhibiting an approximately vertical orientation on the substrate. The crystal structure of (BIEt)(2) was also determined. Read More

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http://dx.doi.org/10.1071/CH11173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549517PMC
August 2011
6 Reads

Raman Spectroscopic Imaging of Cholesterol and Docosahexaenoic Acid Distribution in the Retinal Rod Outer Segment.

Aust J Chem 2011 May;64(5):611-616

Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, 46566.

Raman vibrational spectroscopic imaging was performed on retinal rod cells isolated from bullfrogs (Rana catesbeiana). The Raman spectra enable determination of the lipid and protein rich rod outer segment (ROS) from the nucleus and inner segment of the cell. Peak fitting analysis of spectra obtained from individual rod photoreceptor cells show characteristic vibrational modes that can be associated with cholesterol and docosahexaenoic acid containing lipids. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142917PMC

An Oxidized Abasic Lesion as an Intramolecular Source of DNA Adducts.

Aust J Chem 2011 Apr;64(4):438-442

Department of Chemistry, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA.

5'-(2-Phosphoryl-1,4-dioxobutane) (DOB) is a lesion produced in DNA via a variety of damaging agents. The DOB lesion spontaneously generates - and -but-2-en-1,4-dial () via β-elimination. - and -but-2-en-1,4-dial forms exocyclic adducts with nucleosides. Read More

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http://dx.doi.org/10.1071/CH10420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225716PMC
April 2011
1 Read

New Class of Hydroxy-Substituted Squaraine Rotaxane.

Aust J Chem 2010 ;63(5):792-796

Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46545, USA.

A templated macrocyclization reaction was used to permanently encapsulate a highly fluorescent hydroxy-substituted squaraine dye inside a tetralactam macrocycle. The free squaraine dye is quite rigid due to internal hydrogen bonding and its photophysical properties hardly change upon encapsulation. A combination of X-ray and NMR data show that the surrounding tetralactam macrocycle adopts an unusually rigid chair conformation and does not undergo rapid pirouetting. Read More

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http://dx.doi.org/10.1071/CH09671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903750PMC
January 2010

Eu(III) Complexes of Octadentate 1-Hydroxy-2-pyridinones: Stability and Improved Photophysical Performance[].

Aust J Chem 2009 Oct;62(10):1300-1307

Chemical Sciences Division, Lawrence Berkeley National Laboratories, 1 Cyclotron Road, Mail Stop 70A1150, Berkeley, CA, 94720.

The luminescence properties of lanthanoid ions can be dramatically enhanced by coupling them to antenna ligands that absorb light in the UV/visible and then efficiently transfer the energy to the lanthanoid center. The synthesis and the complexation of Ln(III) cations (Ln=Eu; Gd) for a ligand based on four 1-hydroxy-2-pyridinone (1,2-HOPO) chelators appended to a ligand backbone derived by linking two L-lysine units (3LI-bis-LYS) is described. This octadentate Eu(III) complex ([Eu(3LI-bis-LYS-1,2-HOPO)](-)) has been evaluated in terms of its thermodynamic stability, UV/visible absorption and luminescence properties. Read More

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http://www.publish.csiro.au/?paper=CH09314
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http://dx.doi.org/10.1071/CH09314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883173PMC
October 2009
11 Reads

Saliniquinones A-F, New Members of the Highly Cytotoxic Anthraquinone-γ-Pyrones from the Marine Actinomycete

Aust J Chem 2010 Jun;63(6)

Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, CA 92093-0204, USA.

Six new anthraquinone-γ-pyrones, saliniquinones A-F (-), which are related to metabolites of the pluramycin/altromycin class, were isolated from a fermentation broth of the marine actinomycete (strain CNS-325). Their structures were determined by analysis of one- and two-dimensional NMR spectroscopic and high-resolution mass spectrometric data. The relative and absolute configurations of compounds - were determined by analysis of NOESY NMR spectroscopic data and by comparison of circular dichroism and optical rotation data with model compounds found in the literature. Read More

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http://dx.doi.org/10.1071/CH10068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820018PMC
June 2010
1 Read

Synthesis of Michael Acceptor Ionomers of Poly(4-Sulfonated Styrene-co-Poly(Ethylene Glycol) Methyl Ether Acrylate).

Aust J Chem 2009 Nov;62(11):1496-1500

Department of Chemistry and Biochemistry & California NanoSystems Institute, University of California, Los Angeles, 607 Charles E. Young Drive South, Los Angeles, California 90095-1569.

Ionomers containing sodium 4-styrene sulfonate (4SS) and poly(ethylene glycol) methyl ether acrylate (PEGA) were synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization. The polymerization was mediated by 1-phenylethyl dithiobenzoate chain transfer agent in a dimethylformamide/water solvent system. Well-defined copolymers of pPEGA-co-4SS were produced with molecular weights ranging from 10 kDa to 40 kDa and polydispersity indices (PDIs) of 1. Read More

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http://dx.doi.org/10.1071/CH09398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086289PMC
November 2009
4 Reads

Total Synthesis of (±)-Vibsanin E.

Aust J Chem 2009 ;62(9):980-982

School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, 4072, Queensland, Australia.

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http://dx.doi.org/10.1071/CH09267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033558PMC
January 2009
2 Reads
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