565,920 results match your criteria Australia and New Zealand Health Policy [Journal]


C anatomy can evolve via a single developmental change.

Ecol Lett 2018 Dec 17. Epub 2018 Dec 17.

Department of Animal and Plant Sciences, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK.

C photosynthesis is a complex trait that boosts productivity in warm environments. Paradoxically, it evolved independently in numerous plant lineages, despite requiring specialised leaf anatomy. The anatomical modifications underlying C evolution have previously been evaluated through interspecific comparisons, which capture numerous changes besides those needed for C functionality. Read More

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December 2018

Non-canonical AR activity facilitates endocrine resistance in breast cancer.

Endocr Relat Cancer 2019 Feb;26(2):251-264

Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.

The role of androgen receptor (AR) in endocrine-resistant breast cancer is controversial and clinical trials targeting AR with an AR antagonist (e.g., enzalutamide) have been initiated. Read More

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February 2019

The development of anticipatory action planning in children with unilateral cerebral palsy.

Res Dev Disabil 2018 Dec 14;85:163-171. Epub 2018 Dec 14.

Department of Paediatrics, Monash University, Clayton, Victoria, 3168, Australia; School of Occupational Therapy, La Trobe University, Bundoora, Victoria, 3168, Australia; Victorian Paediatric Rehabilitation Service, Monash Children's Hospital, 246 Clayton Rd, Clayton, Victoria, 3168, Australia. Electronic address:

Background Previous studies suggest that compromised bimanual performance experienced by children with unilateral cerebral palsy (CP) is not only due to difficulties in action execution but may also be a result of impaired anticipatory action planning. Aims The effect of age and side of hemiplegia were examined and the relationship between anticipatory action planning, unimanual capacity and bimanual performance was explored. Methods and procedures Using a multi-centre, prospective, cross-sectional observational design, anticipatory action planning was analyzed in 104 children with unilateral cerebral palsy, aged 6-12 years, using the sword task. Read More

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December 2018
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Treating hyperuricemia related non-alcoholic fatty liver disease in rats with resveratrol.

Biomed Pharmacother 2018 Dec 14;110:844-849. Epub 2018 Dec 14.

The Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou 310023, Zhejiang, China. Electronic address:

Background Hyperuricemia is a recognised risk factor for the development of nonalcoholic fatty liver disease (NAFLD). This study aims to investigate the therapeutic effect of resveratrol (RES) on the treatment of hyperuricemia-related NAFLD in rats and the underlying mechanisms. Methods NAFLD with hyperuricemia was induced in rats using high-yeast high-fat diet containing potassium oxonate. Read More

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December 2018

Process intensification of anaerobic digestion: Influence on mixing and process performance.

Bioresour Technol 2018 Dec 7;274:533-540. Epub 2018 Dec 7.

Chemical & Environmental Engineering, School of Engineering, RMIT University, 124 La Trobe St., Melbourne, VIC 3000, Australia. Electronic address:

The adoption of process intensification to anaerobic digestion can present significant complications for digester mixing and process performance. This work investigated how increasing the solids concentration of the digester sludge influenced the process at various mixing energy inputs. Based on the results, adequate mixing is defined qualitatively as the input of sufficient energy to mobilize the reactor contents without producing significant regions of inhibitory shear force. Read More

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December 2018

Ambient PM air pollution and cardiovascular disease prevalence: Insights from the 33 Communities Chinese Health Study.

Environ Int 2018 Dec 14;123:310-317. Epub 2018 Dec 14.

Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Guangdong Provincial Engineering Technology Research Center of Environmental and Health risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. Electronic address:

Backgrounds: Evidence on the association between long-term exposure to particulate matter with aerodynamic diameter ≤2.5 μm (PM) and cardiovascular disease (CVD) is scarce in developing countries. Moreover, few studies assessed the role of the PM (≤1. Read More

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December 2018

Current perspectives of Australian therapists on rehabilitation and return to sport after anterior cruciate ligament reconstruction: A survey.

Phys Ther Sport 2018 Dec 10;35:139-145. Epub 2018 Dec 10.

Perth Orthopaedic and Sports Medicine Centre, West Perth, Western Australia, Australia.

Objectives: To investigate views and practices of Australian therapists on rehabilitation and return to sport (RTS) after anterior cruciate ligament reconstruction (ACLR).

Design: Survey-based study.

Setting: Online survey platform. Read More

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December 2018

Systematic review and meta-analysis of basal cortisol levels in Borderline Personality Disorder compared to non-psychiatric controls.

Psychoneuroendocrinology 2018 Dec 10;102:149-157. Epub 2018 Dec 10.

Monash Alfred Psychiatry Research Centre, Central Clinical School, Monash University and The Alfred Hospital, Melbourne, Australia.

Objective: Borderline personality disorder (BPD) is a prevalent, complex, and serious mental disorder involving multiple symptoms and maladaptive behaviour. The underlying psychobiological mechanisms involved are not yet fully understood, but increasing evidence indicates that changes in hypothalamic-pituitary-adrenal stress axis (HPA) activity may contribute to BPD. Whilst various studies have demonstrated elevated levels of cortisol (the end-product of the HPA axis) in BPD sufferers, others have presented opposite findings. Read More

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December 2018

Nutrient removal from high ammonium swine wastewater in upflow microaerobic biofilm reactor suffered high hydraulic load.

J Environ Manage 2018 Dec 14;233:69-75. Epub 2018 Dec 14.

State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, 73 Huanghe Road, Harbin, 150090, PR China.

To understand the ability of an upflow microaerobic biofilm reactor (UMBR) to remove nutrient from manure-free swine wastewater rich in NH with a COD/TN ratio less than 1.00, effect of hydraulic loading rate (HLR) on the microaerobic process was evaluated with a constant reflux ratio of 25 at 25 °C. The results showed that changes in HLR had a remarkable effect on the performance of the UMBR in nutrient removal from the wastewater. Read More

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December 2018

One of us? how facial and symbolic cues to own- versus other-race membership influence access to perceptual awareness.

Cognition 2018 Dec 14;184:19-27. Epub 2018 Dec 14.

Department of Psychology, Center for Brain and Cognitive Sciences, School of Education, Guangzhou University, Guangzhou, China. Electronic address:

Information that conveys racial group membership plays a powerful role in influencing people's information processing including perceptual, memory and evaluative judgments. Yet whether own- and other-race information can differentially impact people's perceptual awareness at a preconscious level remains unclear. Employing a breaking continuous flash suppression (b-CFS) paradigm, we investigated whether compared with other-race stimuli, participants' own-race stimuli would be prioritized to gain privileged access to perceptual awareness. Read More

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December 2018

Breaking habits with mindful snacking? An email-based intervention targeting unwanted snacking habits in an Australian sample.

Eat Behav 2018 Nov 30;32:37-43. Epub 2018 Nov 30.

CSIRO, Health and Biosecurity, Kintore Ave, Adelaide 5001, Australia.

Objective: To investigate the potential for an email-based, mindful eating exercise to improve unwanted snacking habits.

Method: Australian participants (N = 78, 86% female) with unwanted snacking habits engaged in a mindful eating email-based intervention, over a practice period of two weeks. All measures were completed using an online survey. Read More

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November 2018

Does the frequency of administration of long acting injectable antipsychotics impact psychiatric outcomes and adverse effects: A systematic review and meta-analysis.

J Psychiatr Res 2018 Dec 10;109:193-201. Epub 2018 Dec 10.

University of Queensland, School of Medicine, Brisbane, Australia; Metro South Addiction and Mental Health Service, Brisbane, Australia.

Dosing regimens for depot antipsychotics range from two-to twelve-weekly administration. There are limited meta-analytic data regarding the effect of different injection frequencies of the same depot antipsychotic at the equivalent dose on psychiatric outcomes and adverse effects. This study investigated differences in psychiatric outcomes and adverse effects between different frequencies of depot antipsychotics through a systematic review and meta-analysis. Read More

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December 2018

A mouse model for intellectual disability caused by mutations in the X-linked 2'‑O‑methyltransferase Ftsj1 gene.

Biochim Biophys Acta Mol Basis Dis 2018 Dec 14. Epub 2018 Dec 14.

Department of Functional Genomics, Interfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, Felix-Hausdorff-Strasse 8, 17489 Greifswald, Germany.

Mutations in the X chromosomal tRNA 2'‑O‑methyltransferase FTSJ1 cause intellectual disability (ID). Although the gene is ubiquitously expressed affected individuals present no consistent clinical features beyond ID. In order to study the pathological mechanism involved in the aetiology of FTSJ1 deficiency-related cognitive impairment, we generated and characterized an Ftsj1 deficient mouse line based on the gene trapped stem cell line RRD143. Read More

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December 2018

Ambient ozone exposure and depressive symptoms in adolescents: Results of the GINIplus and LISA birth cohorts.

Environ Res 2018 Dec 7;170:73-81. Epub 2018 Dec 7.

Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, Ludwig Maximilian University of Munich; Comprehensive Pneumology Center (CPC) Munich, member DZL, German Center for Lung Research, Munich, Germany; Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany; Allergy and Lung Health Unit, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia. Electronic address:

Background: Depression has been associated with air pollution, as reported by animal and epidemiological studies. However, the relationship between ozone exposure and depression, especially among adolescents, is scarcely investigated.

Objectives: The study aimed to analyze associations between ozone exposure and depressive symptoms among German adolescents. Read More

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December 2018
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A systematic literature review and critical appraisal of epidemiological studies on outdoor air pollution and tuberculosis outcomes.

Environ Res 2018 Dec 7;170:33-45. Epub 2018 Dec 7.

School of Public Health, Faculty of Medicine, University of Queensland, Herston, Australia; Centre for Air Pollution, Energy and Health Research, Glebe, NSW, Australia.

Ambient air pollution is the leading environmental risk factor for disease globally. Air pollutants can increase the risk of some respiratory infections, but their effects on tuberculosis (TB) are unclear. In this systematic literature review, we aimed to assess epidemiological studies on the association between outdoor air pollutants and TB incidence, hospital admissions and death (collectively referred to here as 'TB outcomes'). Read More

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December 2018

Cerebrospinal fluid ferritin levels predict brain hypometabolism in people with underlying β-amyloid pathology.

Neurobiol Dis 2018 Dec 14. Epub 2018 Dec 14.

Melbourne Dementia Research Centre, The Florey Institute for Neuroscience and Mental Health, The University of Melbourne, Victoria, Australia; Cooperative Research Center for Mental Health, Victoria, Australia. Electronic address:

β-Amyloid pathology is elevated in ~30% of cognitively normal people over 65, and is associated with accelerated neurodegeneration in the pre-clinical stages of Alzheimer's disease. Recent findings reveal that brain iron might also act to propel neurodegeneration in people with underlying amyloid pathology. Here, repeated PET scans of fluorodeoxyglucose (FDG) were used as a biomarker for brain hypometabolism and a downstream biomarker of neurodegeneration to investigate whether levels of ferritin in the cerebrospinal fluid (CSF; a reporter of brain iron load) are associated with prodromal disease progression of people with high β-amyloid pathology determined by established cut-off values in CSF t-tau/Aβ ratio. Read More

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December 2018

IgE blockade in autoimmunity: Omalizumab induced remission of bullous pemphigoid.

Clin Immunol 2018 Dec 14. Epub 2018 Dec 14.

Department of Clinical Immunology, Royal Perth Hospital, Perth, WA 6000, Australia; Institute of Immunology and Infectious Diseases (IIID), Murdoch University, Murdoch, WA 6150, Australia. Electronic address:

Bullous pemphigoid (BP) is a blistering dermopathy and a prototypic antibody-mediated autoimmune disease. Detection of IgG autoantibodies against hemidesmosomal proteins BP180 and/or BP230 are diagnostic and levels can correlate with disease activity. Therapies include corticosteroids and oral immunosuppressants, while intravenous immunoglobulin and rituximab are reserved for treatment resistant cases. Read More

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December 2018
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A tale of two steroids: the importance of the androgens DHEA and DHEAS for early neurodevelopment.

J Steroid Biochem Mol Biol 2018 Dec 14. Epub 2018 Dec 14.

School of Health & Biomedical Sciences, RMIT University - Bundoora Campus, Melbourne, 3083, Australia. Electronic address:

DHEA and DHEAS are neuroactive neurosteroids that interact with several major receptor system in the brain, including sigma (σ), glutamate, and GABA-A receptors. It has been recognized as early as 1952, that the loss of DHEA/DHEAS in adult life is associated with neuropsychiatric disorders (eg schizophrenia, depression). However, the mechanistic role for DHEA/DHEAS in any of these domains remains speculative, not the least because the presence of these androgens in the adrenal gland and brain is largely confined to humans and only some non-human primates. Read More

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December 2018

Mast Cell Granules: Modulating adaptive immune response remotely.

J Allergy Clin Immunol 2018 Dec 14. Epub 2018 Dec 14.

Immune Imaging Program Centenary Institute, Faculty of Medicine and Health The University of Sydney, Camperdown, NSW 2050, Australia; Discipline of Dermatology, Faculty of Medicine and Health University of Sydney, NSW 2006, Australia; Department of Dermatology, Medical University of Vienna, Vienna 1090, Austria.

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December 2018
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Considering the relationship between domestic violence and pet abuse and its significance in the veterinary clinical and educational contexts.

N Z Vet J 2018 Dec 17:1-27. Epub 2018 Dec 17.

a Department of Veterinary Clinical Sciences , University of Melbourne School , Werribee , Victoria , Australia 3030.

This thematic review examines the literature regarding the relationship between domestic violence (DV) and pet abuse (PA) particularly in the veterinary clinical and educational contexts. It examines the significance of this relationship for the veterinary profession including the veterinarian's role and associated legal and ethical obligations, and relevant current veterinary education standards, to identify future clinical and educational directions. Articles were sourced from online databases by searching the keywords without date restrictions. Read More

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December 2018

Differential regulation of cellular stress responses by the endoplasmic reticulum-resident Selenoprotein S (Seps1) in proliferating myoblasts versus myotubes.

Physiol Rep 2018 Dec;6(24):e13926

Centre for Molecular and Medical Research, School of Medicine, Deakin University, Geelong, Australia.

The antioxidant Selenoprotein S (Seps1, Selenos) is an endoplasmic reticulum (ER)-resident protein associated with metabolic and inflammatory disease. While Seps1 is highly expressed in skeletal muscle, its mechanistic role as an antioxidant in skeletal muscle cells is not well characterized. In C2C12 myotubes treated with palmitate for 24 h, endogenous Seps1 protein expression was upregulated twofold. Read More

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December 2018

Bayesian inference of protein conformational ensembles from limited structural data.

PLoS Comput Biol 2018 Dec 17;14(12):e1006641. Epub 2018 Dec 17.

Biochemistry and Structural Biology, University of Lund, Lund, Sweden.

Many proteins consist of folded domains connected by regions with higher flexibility. The details of the resulting conformational ensemble play a central role in controlling interactions between domains and with binding partners. Small-Angle Scattering (SAS) is well-suited to study the conformational states adopted by proteins in solution. Read More

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December 2018

Quality circles for quality improvement in primary health care: Their origins, spread, effectiveness and lacunae- A scoping review.

PLoS One 2018 17;13(12):e0202616. Epub 2018 Dec 17.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.

Quality circles or peer review groups, and similar structured small groups of 6-12 health care professionals meet regularly across Europe to reflect on and improve their standard practice. There is debate over their effectiveness in primary health care, especially over their potential to change practitioners' behaviour. Despite their popularity, we could not identify broad surveys of the literature on quality circles in a primary care context. Read More

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December 2018

Commentary on "Developmental Trajectories and Reference Percentiles for the 6-Minute Walk Test for Children With Cerebral Palsy".

Pediatr Phys Ther 2019 Jan;31(1):60

University of South Australia Adelaide, Australia Novita Children's Services Adelaide, Australia.

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January 2019

CUTICULAR DRUSEN: Risk of Geographic Atrophy and Macular Neovascularization.

Retina 2018 Dec 14. Epub 2018 Dec 14.

LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, New York.

Purpose: Cuticular drusen (CD) have been associated with manifestations of age-related macular degeneration such as atrophy and neovascularization in the macula. In this study, eyes with CD were followed and investigated for the estimated 5-year risk of progression to sequelae of age-related macular degeneration such as geographic atrophy (GA) and macular neovascularization (MNV).

Methods: A consecutive series of patients with CD were followed for the development of GA and MNV. Read More

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December 2018
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Encouraging a Bare Minimum While Striving for the Gold Standard: A Response to the Updated WHO-WFSA Guidelines.

Anesth Analg 2019 Jan;128(1):e12-e13

Journalism, Specialist Anaesthetist, Department of Anaesthesia and Perioperative Medicine, The Alfred Hospital and Monash University, Melbourne, Australia Consultant Anesthesiologist, King Faisal Hospital and Program Director, College of Medicine and Health Sciences University of Rwanda Consultant Anesthesiologist, Addis Ababa University, Ethiopia Consultant Anesthesiologist, Maputo Pain Clinic, Mozambique Anesthesiologist, Dalhousie University, Halifax, Canada Managing Director, Diamedica, United Kingdom Specialist Anaesthetist, Hobart, Tasmania Professor Emeritus, Queen's University, Departments of Anesthesiology, Pediatrics and Physiology, Kingston, Ontario, Canada Professor, Departments of Anesthesiology and Surgery Division of Ambulatory Surgery, Director, Vanderbilt Anesthesia Global Health & Development, Director, Vanderbilt Global Anesthesia Fellowship Affiliate Faculty, Vanderbilt Institute for Global Health, Vanderbilt University School of Medicine and Vanderbilt University Medical Center.

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January 2019

Ixekizumab improves patient-reported outcomes in patients with active psoriatic arthritis and inadequate response to tumour necrosis factor inhibitors: SPIRIT-P2 results to 52 weeks.

Clin Exp Rheumatol 2018 Nov 19. Epub 2018 Nov 19.

Department of Medicine, Rheumatology Research Unit, University of Queensland, Sunshine Coast, QLD, Australia.

Objectives: To report patient-reported outcomes (PROs) of ixekizumab-treated patients with psoriatic arthritis (PsA) and an inadequate response (IR) or intolerance to tumour necrosis factor inhibitors (TNFi) to 52 weeks.

Methods: In SPIRIT-P2, patients with active PsA and an IR or intolerance to TNFi were randomised to ixekizumab 80 mg every 4 weeks (IXEQ4W; N=122) or every 2 weeks (IXEQ2W; N=123), or placebo (PBO; N=118) during the initial 24-week double-blind treatment period. At Week 16, background therapy was modified for IRs; additionally, IRs in the placebo group were re-randomised (1:1) to IXEQ2W or IXEQ4W. Read More

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November 2018
2 Reads

The relationship between pressure ulcer risk assessment and preventative interventions: a systematic review.

J Wound Care 2018 Dec;27(12):862-875

Professor of Nursing, School of Nursing, Midwifery and Paramedicine, Faculty of Health Sciences, Australian Catholic University, 1100 Nudgee Road, Banyo, QLD, Australia 4014. Nursing Research and Practice Development Centre, The Prince Charles Hospital, Rode Rd, Chermside, QLD, Australia 4032. Faculty of Health Sciences, University of Witwatersrand, South Africa.

Objective:: Hospital-acquired pressure ulcers (PU) continue to occur despite an ongoing focus on prevention. The aim of this review was to identify and evaluate primary research which links pressure ulcer risk assessment with prescription and implementation of preventative interventions for hospitalised adults.

Method:: A systematic review of the databases EBSCO CINAHL Complete, EBSCO MEDLINE Complete, Scopus and Web of Science was undertaken, using search terms related to pressure ulcers, hospital-acquired, risk, planning, implementation, prevention and outcome. Read More

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December 2018

Evaluation of alternative intersection treatments at rural crossroads using simulation software.

Traffic Inj Prev 2018 Dec 17:1-7. Epub 2018 Dec 17.

a Accident Research Centre, Monash University , Melbourne , Victoria , Australia.

Objective: Rural roads are characterized by hazardous roadsides and suboptimal geometry yet allow for high travel speeds and unfavorable impact angles. In Victoria, 25% of persons seriously injured and 52% of fatalities occur on rural roads, with 30% occurring at intersections. In the United States, almost twice the number of traffic fatalities occur in rural areas than in urban areas, while accounting for less than half of all vehicle miles traveled and 21% of the population. Read More

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December 2018
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The effect of hospitalization on potentially inappropriate medication use in older adults with chronic kidney disease.

Curr Med Res Opin 2018 Dec 17:1-18. Epub 2018 Dec 17.

a Pharmacy, School of Medicine, College of Health and Medicine, University of Tasmania , Australia.

Objectives: Potentially inappropriate medications (PIMs) use is associated with increased morbidity and mortality in chronic kidney disease (CKD). However, there is paucity of data on how hospitalization affects PIMs use in older adults with CKD. Therefore, we aimed to measure the impact of hospitalization on PIMs use in older CKD patients, and identify factors predicting PIMs use. Read More

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December 2018

Surface Dynamics and Ligand-Core Interactions of Quantum Sized Photoluminescent Gold Nanoclusters.

J Am Chem Soc 2018 Dec 17. Epub 2018 Dec 17.

Department of Materials and Department of Bioengineering, Institute of Biomedical Engineering , Imperial College London , Exhibition Road , London SW7 2AZ , United Kingdom.

Quantum-sized metallic clusters protected by biological ligands represent a new class of luminescent materials; yet the understanding of structural information and photoluminescence origin of these ultrasmall clusters remains a challenge. Herein we systematically study the surface ligand dynamics and ligand-metal core interactions of peptide-protected gold nanoclusters (AuNCs) with combined experimental characterizations and theoretical molecular simulations. We show that the peptide sequence plays an important role in determining the surface peptide structuring, interfacial water dynamics and ligand-Au core interaction, which can be tailored by controlling peptide acetylation, constituent amino acid electron donating/withdrawing capacity, aromaticity/hydrophobicity and by adjusting environmental pH. Read More

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December 2018

Lanthanoid Heteroleptic Complexes with Cucurbit[5]uril and Dicarboxylate Ligands: From Discrete Structures to One-Dimensional and Two-Dimensional Polymers.

Inorg Chem 2018 Dec 17. Epub 2018 Dec 17.

CSIRO Manufacturing , P.O. Box 218, Lindfield , New South Wales 2070 , Australia.

Lanthanoid heteroleptic complexes with cucurbit[5]uril {Q[5]} and two dicarboxylate ligands, e.g., diglycolic acid (HDGC) and glutaric acid (HGT), have been investigated with six new compounds featuring a tetrametallic and dimetallic discrete structures, a one-dimensional (1D) polymer, and three two-dimensional (2D) polymers with a unique honeycomb-type topology being synthesized and structurally characterized. Read More

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December 2018

Working with consumers who hear voices: The experience of early career nurses in mental health services in Australia.

Int J Ment Health Nurs 2018 Dec 17. Epub 2018 Dec 17.

Faculty of Health, University of Technology Sydney, Sydney, New South Wales, Australia.

Mental health consumers who hear voices frequently experience distress and express a desire to discuss their voice-hearing experience. Nurses do not regularly demonstrate a willingness to engage in such discussions. With the introduction of educational strategies that develop empathy and an understanding of voice-hearing experiences, it is anticipated that early career nurses will be able to translate such understanding into their professional nursing practice. Read More

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December 2018

An appraisal of the role of specific bacteria in the initial pathogenesis of periodontitis.

J Clin Periodontol 2018 Dec 17. Epub 2018 Dec 17.

Department of Applied Oral Sciences, Center for Periodontology, The Forsyth Institute, Cambridge, Massachusetts, USA.

Background: Historically, inflammatory periodontal diseases (gingivitis and periodontitis) have been recognized as being primarily of bacterial origin. Bacteria are necessary for disease development, but the presence of specific bacteria does not guarantee progression to periodontitis. Periodontitis is a multifactorial disease; specific bacteria are associated with disease, but may not be the target of treatment. Read More

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December 2018

Dancing Dorsal Quadrilaterals: A Novel Peripherally Induced Movement Disorder.

JAMA Neurol 2018 Dec 17. Epub 2018 Dec 17.

The Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Division of Neurology, University of Toronto, Toronto, Ontario, Canada.

Importance: Recognized peripherally induced movement disorders include the painful legs moving toes syndrome, postamputation dyskinesias, and belly dancer dyskinesias.

Objective: To introduce and characterize the dancing dorsal quadrilaterals, a novel peripherally induced movement disorder that predominantly affects dorsal quadrilateral muscles (trapezius and rhomboids) after upper spine instrumentation.

Design, Setting, And Participants: Between 1990 and 2015, a total of 4 patients who developed abnormal movements of the dorsal quadrilateral muscles after upper spine instrumentation were referred to movement disorders clinics at 3 academic medical centers in the United States, Canada, and Argentina. Read More

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December 2018
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Telephone Call After Pediatric Discharge.

JAMA Pediatr 2018 Dec 17. Epub 2018 Dec 17.

Sydney Medical School Nepean, The University of Sydney, Sydney, Australia.

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December 2018

Minimum Information about an Uncultivated Virus Genome (MIUViG).

Nat Biotechnol 2018 Dec 17. Epub 2018 Dec 17.

US Department of Energy Joint Genome Institute, Walnut Creek, California, USA.

We present an extension of the Minimum Information about any (x) Sequence (MIxS) standard for reporting sequences of uncultivated virus genomes. Minimum Information about an Uncultivated Virus Genome (MIUViG) standards were developed within the Genomic Standards Consortium framework and include virus origin, genome quality, genome annotation, taxonomic classification, biogeographic distribution and in silico host prediction. Community-wide adoption of MIUViG standards, which complement the Minimum Information about a Single Amplified Genome (MISAG) and Metagenome-Assembled Genome (MIMAG) standards for uncultivated bacteria and archaea, will improve the reporting of uncultivated virus genomes in public databases. Read More

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December 2018
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Reported benefits of peer support group involvement by adults with hearing loss.

Int J Audiol 2018 Dec 17:1-8. Epub 2018 Dec 17.

f College of Nursing and Health Sciences , Flinders University , Adelaide , Australia.

The purpose of this study was to better understand the benefits of self-help group involvement by adults with hearing loss. A secondary content analysis of interview transcripts of participants from a previous study on the impact of stigma on help-seeking was carried out. Ten members (aged 55-76 years) of self-help groups for persons with hearing loss in the United States of America and Canada participated in the interviews. Read More

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December 2018

Reference Rot in Medical Publications

Ir Med J 2018 Oct 11;111(9):827. Epub 2018 Oct 11.

University of Adelaide, Director of Emergency Medicine, Riverland General Hospital, South Australia

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October 2018

Reanalysis and optimisation of bioinformatic pipelines is critical for mutation detection.

Hum Mutat 2018 Dec 17. Epub 2018 Dec 17.

Centre for Clinical Genetics, Sydney Children's Hospital, Randwick, Australia.

Rapid advances in genomic technologies have facilitated the identification pathogenic variants causing human disease. We report siblings with developmental and epileptic encephalopathy due to a novel, shared heterozygous pathogenic 13 bp duplication in SYNGAP1 (c.435_447dup, p. Read More

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December 2018

Systematic review of ganciclovir pharmacodynamics during the prevention of cytomegalovirus infection in adult solid organ transplant recipients.

Rev Med Virol 2018 Dec 17:e2023. Epub 2018 Dec 17.

Serology and Virology Division, NSW Health Pathology, Prince of Wales Hospital, Sydney, New South Wales, Australia.

Human cytomegalovirus (CMV) represents the most common infection among recipients of solid organ transplants (SOTs). Previous meta-analysis showed 0.8% of SOT recipients developed CMV disease whilst receiving valganciclovir (ValGCV) prophylaxis. Read More

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December 2018

Comparison of continuous flow versus demand oxygen delivery systems in patients with COPD: A systematic review and meta-analysis.

Respirology 2018 Dec 17. Epub 2018 Dec 17.

Institute for Pulmonary Rehabilitation Research, Schoen Klinik Berchtesgadener Land, Schoenau am Koenigssee, Germany.

Demand oxygen delivery systems (DODS) enable prolongation of liquid oxygen cylinder life compared to continuous oxygen flow (CONT) use. Evidence is lacking, however, regarding their efficacy. This study investigated the literature comparing liquid-based CONT to DODS in patients with chronic obstructive pulmonary disease (COPD). Read More

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December 2018

RAB27A promotes melanoma cell invasion and metastasis via regulation of pro-invasive exosomes.

Int J Cancer 2018 Dec 17. Epub 2018 Dec 17.

The Centenary Institute, The University of Sydney, Newtown, NSW, Australia.

Despite recent advances in targeted and immune-based therapies, advanced stage melanoma remains a clinical challenge with a poor prognosis. Understanding the genes and cellular processes that drive progression and metastasis is critical for identifying new therapeutic strategies. Here, we found that the GTPase RAB27A was overexpressed in a subset of melanomas, which correlated with poor patient survival. Read More

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December 2018

Care prior to and during subsequent pregnancies following stillbirth for improving outcomes.

Cochrane Database Syst Rev 2018 Dec 17;12:CD012203. Epub 2018 Dec 17.

NHMRC Centre of Research Excellence in Stillbirth, Mater Research Institute - The University of Queensland (MRI-UQ), Level 3 Aubigny Place, Mater Health Services, Brisbane, Queensland, Australia, 4101.

Background: Stillbirth affects at least 2.6 million families worldwide every year and has enduring consequences for parents and health services. Parents entering a subsequent pregnancy following stillbirth face a risk of stillbirth recurrence, alongside increased risks of other adverse pregnancy outcomes and psychosocial challenges. Read More

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December 2018

Workplace interventions for reducing sitting at work.

Cochrane Database Syst Rev 2018 Dec 17;12:CD010912. Epub 2018 Dec 17.

Institute for Health and Sport (IHES), Victoria University, Melbourne, Victoria, Australia.

Background: A large number of people are employed in sedentary occupations. Physical inactivity and excessive sitting at workplaces have been linked to increased risk of cardiovascular disease, obesity, and all-cause mortality.

Objectives: To evaluate the effectiveness of workplace interventions to reduce sitting at work compared to no intervention or alternative interventions. Read More

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December 2018

Heterologous expression and biochemical characterisation of cyanotoxin biosynthesis pathways.

Nat Prod Rep 2018 Dec 17. Epub 2018 Dec 17.

School of Environmental and Life Sciences, University of Newcastle, Callaghan 2308, Australia.

Covering: up to 2018Marine and freshwater cyanobacteria produce a variety of toxic compounds that pose a threat to the health of humans, livestock and natural ecosystems world-wide. Significant research efforts have been directed towards understanding the biosynthesis of these cyanotoxins in an attempt to reduce their deleterious effects on water quality and, more recently, to harness their biotechnological potential. While a variety of complementary methods (such as bioinformatic analyses and isotope feeding studies) have been employed over the last three decades to address knowledge gaps in this field, this review focuses on the utility of heterologous expression and biochemical studies, including emerging technologies for engineering and expressing complete cyanotoxin gene clusters. Read More

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December 2018

Long-Term Cognitive Effects of Kratom (Mitragyna speciosa Korth.) Use.

J Psychoactive Drugs 2018 Dec 15:1-9. Epub 2018 Dec 15.

a Centre for Drug Research , Universiti Sains Malaysia , Penang , Malaysia.

Kratom or Mitragyna speciosa (Korth.) is a medicinal plant of Southeast Asia. As a result of its opioid-like effects, it remains unknown whether consumption of kratom tea is associated with impaired cognitive function. Read More

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December 2018

Cardiometabolic risks in PCOS: a review of the current state of knowledge.

Expert Rev Endocrinol Metab 2018 Dec 4:1-11. Epub 2018 Dec 4.

a Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine , Monash University , Melbourne , Australia.

Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting up to 18% women of reproductive age. It is associated with a range of metabolic, reproductive, and psychological features. Current evidence indicates a role of PCOS in the development of metabolic and increased cardiovascular risk factors (CVRF) with implications for compromised cardiovascular endpoint disease, which may have a considerable impact on health and health care costs. Read More

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December 2018

Can Artificial Intelligence Make Screening Faster, More Accurate, and More Accessible?

Asia Pac J Ophthalmol (Phila) 2018 Dec 17. Epub 2018 Dec 17.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Diabetic retinopathy, glaucoma, and age-related macular degeneration are leading causes of vision loss and blindness worldwide. They tend to be asymptomatic in the early phase of disease and therefore require active screening programs to identify the patients requiring referral and treatment. Deep learning-based artificial intelligence technology has recently become a major topic in the field of ophthalmology. Read More

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December 2018
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