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    2908 results match your criteria Australasian Journal of Dermatology [Journal]

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    Colchicine in dermatology: A review.
    Australas J Dermatol 2018 Feb 12. Epub 2018 Feb 12.
    Department of Dermatology, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.
    Colchicine is an anti-inflammatory agent that has been used for decades for the treatment of various diseases including gout, familial Mediterranean fever and pericarditis and in recent years for dermatological indications including chronic urticaria, cutaneous vasculitis and psoriasis. Despite its efficacy in various cutaneous diseases, the use of colchicine may be limited by concerns over its side-effects and the potential for toxicity. This article reviews the current literature on the pharmacology of colchicine and its clinical applications in dermatology. Read More

    Comparative safety and efficacy of topical mometasone furoate with other topical corticosteroids.
    Australas J Dermatol 2018 Feb 7. Epub 2018 Feb 7.
    Ego Pharmaceuticals, Braeside, Victoria, Australia.
    Derivatives of hydrocortisone, such as mometasone furoate, a (2') furoate-17 ester with chlorine substitutions at positions 9 and 21, have been designed to improve efficacy and reduce the incidence of adverse effects. An extensive literature search of MEDLINE, Embase and other databases was conducted to review the safety and efficacy of various formulations of topical mometasone furoate. Mometasone furoate exhibits high potency with greater anti-inflammatory activity and a longer duration of action than betamethasone. Read More

    Monilethrix: A case report imaged by trichoscopy, reflectance confocal microscopy and histopathology.
    Australas J Dermatol 2018 Feb 5. Epub 2018 Feb 5.
    Alopecia and Hair Disorders Section, Dermato-Oncology Clinic, Faculty of Medicine, Autonomous National University of Mexico, Mexico City, Mexico.

    Nickel hypersensitivity following closure of atrial septal defect: A case report and review of the literature.
    Australas J Dermatol 2018 Jan 29. Epub 2018 Jan 29.
    Northern Clinical School, University of Sydney, Sydney, New South Wales, Australia.
    We present an unusual case where symptoms of headache and chest pain persisted for 3 years following the implantation of a septal occluder device for an atrial septal defect despite endothelialisation of the device. The patient was found to have nickel hypersensitivity on patch testing. Following the removal of the device the patient had complete resolution of headaches and chest pain up to 10 months post-explantation. Read More

    Bridge flap repair for central nasal dorsum defect.
    Australas J Dermatol 2018 Jan 23. Epub 2018 Jan 23.
    Dermatological Surgery Unit, Skin Cancer Institute, Tauranga, New Zealand.
    Surgery of the nose to remove skin cancer often requires the use of local flaps. We present a defect after the extirpation of a previously incompletely excised infiltrative squamous cell carcinoma, which we repaired with a Bridge flap, a bipedicled and subcutaneous islanded flap whose excellent vascularity allows reliable reconstruction and rapid mobilisation, with dependable results. Read More

    Hidradenitis suppurativa, a review of pathogenesis, associations and management. Part 2.
    Australas J Dermatol 2018 Jan 23. Epub 2018 Jan 23.
    Ingham Institute for Applied Medical Research, Sydney, NSW, Australia.
    Hidradenitis suppurativa is a chronic, painful, autoinflammatory condition resulting in nodules, abscesses and sinus tracts. We present an evidence-based review providing new understanding of the pathogenesis of hidradenitis suppurativa and associated comorbidities. By the nature of their speciality, dermatologists are uniquely positioned to investigate and treat patients. Read More

    Hidradenitis suppurativa, a review of pathogenesis, associations and management. Part 1.
    Australas J Dermatol 2018 Jan 21. Epub 2018 Jan 21.
    Ingham Institute for Applied Medical Research, Sydney, New South Wales, Australia.
    Hidradenitis suppurativa is a chronic, painful, autoinflammatory condition resulting in nodules, abscesses and sinus tracts. We present an evidence-based review providing new understanding of the pathogenesis of hidradenitis suppurativa and associated comorbidities. By the nature of their speciality, dermatologists are uniquely positioned to investigate and treat patients with this condition. Read More

    The burden of non-melanoma skin cancers in Auckland, New Zealand.
    Australas J Dermatol 2018 Jan 19. Epub 2018 Jan 19.
    Department of Epidemiology and Biostatistics, School of Population Health, University of Auckland, Auckland, New Zealand.
    Background/objectives: As the New Zealand Cancer Registry does not require mandatory reporting of non-melanoma skin cancers (NMSC), basal cell carcinomas (BCC) and squamous cell carcinomas (SCC), the clinical burden of these diseases is unknown.

    Methods: A retrospective review of all patients with histopathology performed allowed us to estimate invasive BCC and SCC in the Auckland region in 2008 (population 1.44 million). Read More

    Retrospective audit of patients referred for further treatment following Mohs surgery for non-melanoma skin cancer.
    Australas J Dermatol 2018 Jan 18. Epub 2018 Jan 18.
    Department of Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
    Background/objectives: To describe the characteristics, subsequent management and outcomes of patients referred for further management following Mohs micrographic surgery (MMS) for basal cell carcinoma (BCC) and squamous cell carcinoma (SCC).

    Methods: Retrospective analysis of patients referred to a quaternary cancer centre from 2000 to 2015.

    Results: In total, 83 lesions in 82 patients were referred for further management; 52 (62%) were SCC and 80 (96%) were located in the head and neck. Read More


    Baseline patients' characteristics as predictors for therapeutic survival and response in patients with psoriasis on biological treatments.
    Australas J Dermatol 2018 Jan 8. Epub 2018 Jan 8.
    Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia.
    Background/objectives: Biological agents provide a relatively safe and promising long-term therapeutic option for patients with moderate to severe psoriasis in whom conventional treatment has failed. However, these agents are not effective in all patients. We aimed to examine the association of baseline patients' characteristics with the short-term efficacy and the long-term survival of biological therapies in patients with moderate to severe psoriasis. Read More

    Dermoscopy of arteriovenous tumour: A morphological study of 39 cases.
    Australas J Dermatol 2018 Jan 5. Epub 2018 Jan 5.
    Department of Dermatology, University Hospital of Alicante, Alicante, Spain.
    Background/objectives: Arteriovenous tumour is a distinct, benign, acquired vascular lesion that can be misdiagnosed.

    Methods: A dermoscopic examination of 39 cases of arteriovenous tumours collected from four Spanish hospitals was performed to evaluate specific dermoscopic criteria and patterns.

    Results: The most common structures found were vascular, 95% of cases (37/39); 90% (35/39) were non-arborising telangiectasia. Read More

    Association between bullous pemphigoid and malignancy: A meta-analysis.
    Australas J Dermatol 2018 Jan 4. Epub 2018 Jan 4.
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
    It has been suggested that bullous pemphigoid is associated with an increased risk of malignancy, but the evidence is inconsistent. Therefore, a meta-analysis was conducted to explore this association. PUBMED and Embase were searched for studies investigating the association between bullous pemphigoid and malignancy. Read More

    Lichen planopilaris: A retrospective study of 32 cases in an Australian tertiary referral hair clinic.
    Australas J Dermatol 2018 Jan 3. Epub 2018 Jan 3.
    Skin and Cancer Foundation Inc, Melbourne, Victoria, Australia.
    Background/objectives: Lichen planopilaris is a primary lymphocytic cicatricial alopecia. Management of patients with lichen planopilaris is difficult due to a paucity of high-quality data on its epidemiology and pathogenesis and the efficacy of therapies. The purpose of this study was to report the characteristics and treatment outcomes of patients with lichen planopilaris in a tertiary referral centre. Read More

    Comparison of skin cancers in liver and renal transplant recipients: Results of a prospective study in an Australian tertiary referral centre.
    Australas J Dermatol 2018 Jan 2. Epub 2018 Jan 2.
    Department of Dermatology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
    Background/objectives: Organ transplant recipients (OTR) have an increased risk of skin cancers compared with the general population.

    Methods: A prospective study of renal (RTR) and liver transplant recipients (LTR) was conducted in a single New South Wales tertiary referral centre over 60 months. Initial and subsequent visit data were recorded in our transplant database. Read More

    Smartphone apps for skin cancer diagnosis: Implications for patients and practitioners.
    Australas J Dermatol 2018 Jan 2. Epub 2018 Jan 2.
    Department of Dermatology, Royal North Shore Hospital, Sydney, New South Wales, Australia.
    A research team at Stanford recently reported that their deep convolutional neural network had learned to classify skin cancer with a level of competence equivalent to that of board-certified dermatologists. It is possible that in time, and using larger datasets, such software may surpass the average doctor in diagnostic ability, and that highly accurate technology may be available to both clinicians and patients via smartphones. This technology is poised to change the landscape of skin cancer diagnosis for both physicians and patients, but whether such changes are beneficial will depend on how they are regulated and implemented. Read More

    Hyperbaric oxygen therapy: An alternative treatment for radiation-induced cutaneous ulcers.
    Australas J Dermatol 2017 Dec 29. Epub 2017 Dec 29.
    Department of Dermatology, Hospital Costa del Sol, Marbella, Spain.
    Radiotherapy is a widely recognised treatment for non-melanoma skin cancer. We report three cases of radiation-induced skin ulcers in which hyperbaric oxygen therapy was administered in 90-min sessions, 5 days a week at 2.4 absolute atmospheres in a multiplace hyperbaric chamber. Read More

    Mycosis fungoides occurring at the site of previous herpes zoster eruption.
    Australas J Dermatol 2017 Dec 26. Epub 2017 Dec 26.
    Department of Dermatology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
    Numerous clinicopathological variants of mycosis fungoides have been described in the literature. Dermatomal or zosteriform mycosis fungoides is one reported variant but a clear aetiology has never been documented. We report a case of mycosis fungoides proved by biopsy and immunohistochemistry that developed in a 55-year-old man at the site of previous herpes zoster eruption. Read More

    Itching for answers: Prevalence and severity of pruritus in psoriasis.
    Australas J Dermatol 2017 Dec 26. Epub 2017 Dec 26.
    Department of Dermatology, Northern Clinical School, University of Sydney, Sydney, New South Wales, Australia.
    Background/objectives: Pruritus is the most frequently reported complaint or symptom for psoriasis patients. Despite the morbidity associated with pruritus in psoriasis few studies have evaluated the prevalence of itch in psoriasis with the current use of biological agents.

    Method: This was a multi-site cross-sectional observational study conducted in New South Wales, Australia. Read More

    Treatment of severe recalcitrant pyoderma gangrenosum with ustekinumab.
    Australas J Dermatol 2017 Dec 4. Epub 2017 Dec 4.
    Department of Dermatology, Monash Health, Clayton, Victoria, Australia.
    An increased expression of interleukin-23 has been observed in patients with pyoderma gangrenosum, leading to the use of ustekinumab as a therapeutic option. We report the successful use of ustekinumab in three patients with treatment-resistant pyoderma gangrenosum of varying clinical presentations. Read More

    Nicotinamide and skin cancer chemoprevention: The jury is still out.
    Australas J Dermatol 2018 Feb 28;59(1):6-9. Epub 2017 Nov 28.
    Skin and Cancer Foundation, Melbourne, Victoria, Australia.
    Following the publication of the results of a Phase III trial, the administration of oral nicotinamide has been widely advocated as effective in non-melanoma skin cancer chemoprevention in high-risk individuals. However, I performed a Bayesian analysis of the reported findings and show there is insufficient evidence to demonstrate its efficacy, highlighting the significant probability that the positive conclusions drawn will not be reproducible. Given the potential widespread use of oral nicotinamide, future position statements regarding its efficacy are likely to require higher standards of evidence. Read More

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