3,567 results match your criteria Australasian Emergency Nursing Journal [Journal]
J Phycol 2018 Dec 2. Epub 2018 Dec 2.
Institute for Marine and Antarctic Studies, University of Tasmania, Launceston, TAS, 7250, Australia.
Temperate kelp forests (Laminarians) are threatened by temperature stress due to ocean warming and photoinhibition due to increased light associated with canopy loss. However, the potential for evolutionary adaptation in kelp to rapid climate change is not well known. This study examined family-level variation in physiological and photosynthetic traits in the early life-cycle stages of the ecologically important Australasian kelp Ecklonia radiata and the response of E. Read More
ANZ J Surg 2018 Nov 29. Epub 2018 Nov 29.
Victorian Audit of Surgical Mortality (VASM), Royal Australasian College of Surgeons, Melbourne, Victoria, Australia.
Background: The Victorian Audit of Surgical Mortality (VASM) seeks to peer review all deaths associated with surgical care in Victoria, Australia. The effectiveness of the VASM as an educational and quality improvement tool is dependent on the accuracy of source data it receives. We aimed to examine the accuracy and quality of source data provided by the treating surgeon for peer review, and the inter-rater concordance level between the external validator findings and the treating surgeon. Read More
ANZ J Surg 2018 Nov 29. Epub 2018 Nov 29.
Discipline of Surgery, The University of Adelaide, The Queen Elizabeth Hospital, Adelaide, South Australia, Australia.
Background: Clinical decision making is a core competency of surgical practice, involving a continuous and evolving process of data interpretation and evaluation. The aim of this article is twofold. First, to recognize patient deaths where a clinical incident arose following unsatisfactory clinical decision making, determining where in the clinical decision-making process each failure occurred. Read More
Zootaxa 2018 Oct 16;4500(3):443-450. Epub 2018 Oct 16.
Key Laboratory of Wetland Ecology and Environment, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, Changchun 130102, P. R. China..
Two new species of Austrophthiracarus (Oribatida: Steganacaridae) from national parks on the North Island of New Zealand are described: Austrophthiracarus taranaki sp. nov. from moss along tracks in Wilkies Pools, Egmont National Park, Taranaki and Austrophthiracarus whirinaki sp. Read More
Zootaxa 2018 Oct 26;4504(4):595-600. Epub 2018 Oct 26.
Muséum national d'Histoire naturelle, CP 50, 45 rue Buffon, F-75005 Paris, France..
A new species of Agapophyta Guérin-Méneville, 1831 (Hemiptera: Heteroptera: Tessaratomidae: Oncomerinae), Agapophyta kmenti sp. nov., is described from the Tanimbar Islands, Indonesia, male and female genitalia are illustrated. Read More
ANZ J Surg 2018 Nov 28. Epub 2018 Nov 28.
Colorectal Surgery Unit, Royal Prince Alfred Hospital, Institute of Academic Surgery, Sydney, New South Wales, Australia.
In general surgery, observational studies are disregarded and often seen as non-noteworthy research. We intend to defend the use of surveys in general surgery and colorectal surgery. This review highlights the historical importance and contemporary utility of surveys internationally and in our region, thus reminding Australasian surgeons and clinicians in numerous disciplines of the usefulness of this research tool. Read More
Intern Med J 2018 Nov 28. Epub 2018 Nov 28.
Consultant Nephrologist, Princess Alexandra Hospital.
Perioperative medicine is rapidly emerging as a key discipline to address the specific needs of high-risk surgical groups, such as those on chronic dialysis. Crude hospital separations rates for chronic dialysis patients are considerably higher than patients with normal renal function, with up to 15% of admission being related to surgical intervention. Dialysis dependency carries substantial mortality and morbidity risk compared to patients with normal renal function. Read More
Reprod Fertil Dev 2018 Nov 27. Epub 2018 Nov 27.
The high diversity of native Philippine murid rodents includes an old endemic group, the chrotomyines, which are the sister group of the Australasian hydromyines. Herein we detail their interspecific diversity of relative testes mass (RTM) and sperm morphology. We find that in chrotomyines, as in the Australasian hydromyines, testes mass relative to body mass differs by an order of magnitude across the species and ranges from a large RTM in Soricomys and Chrotomys species to a small RTM in Apomys. Read More
Kidney Int 2018 Nov 22. Epub 2018 Nov 22.
School of Medicine, University of Melbourne, Melbourne, Victoria, Australia; Department of Intensive Care, Austin Hospital, Heidelberg, Victoria, Australia; Department of Intensive Care, Royal Melbourne Hospital, Parkville, Victoria, Australia; School of Public Health and Preventative Medicine, Monash University, Melbourne, Victoria, Australia; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia. Electronic address:
Reliable estimates of the long-term outcomes of acute kidney injury (AKI) are needed to inform clinical practice and guide allocation of health care resources. This systematic review and meta-analysis aimed to quantify the association between AKI and chronic kidney disease (CKD), end-stage kidney disease (ESKD), and death. Systematic searches were performed through EMBASE, MEDLINE, and grey literature sources to identify cohort studies in hospitalized adults that used standardized definitions for AKI, included a non-exposed comparator, and followed patients for at least 1 year. Read More
Am J Kidney Dis 2018 Dec;72(6):776-778
Australasian Kidney Trials Network, Faculty of Medicine, The University of Queensland, Brisbane, Australia; Department of Nephrology, Princess Alexandra Hospital, Brisbane, Australia; Translational Research Institute, Brisbane, Australia. Electronic address:
Sci Total Environ 2018 Nov 17;655:147-157. Epub 2018 Nov 17.
Key Laboratory of Agro-ecological Processes in Subtropical Regions, Chinese Academy of Sciences, Changsha 410125, PR China; Dongting Lake Station for Wetland Ecosystem Research, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, PR China. Electronic address:
Dongting Lake is the second largest freshwater lake in China and is one of the globally important wintering sites for migratory waterbirds in the East Asian-Australasian Flyway. Crucial sites and environmental variables for wintering migratory waterbirds are of great concern in the Dongting Lake wetlands. In this research, based on annual (2003/2004-2016/2017) waterbird and habitat census data, we recognized the crucial sites for waterbirds during wintering seasons by comparing the difference of waterbird populations at the community, foraging guild and species levels in different natural wetlands within East Dongting Lake, and then identified the crucial environmental variables affecting waterbird distributions by analyzing the relationship between waterbird populations and the environmental variables, including vegetation area, mudflat area, water area with the depth of 0-20 cm, water area with the depth of 20-50 cm, water area with the depth of 50-100 cm, water area with the depth >100 cm, growth status of vegetation (Min, Mean and Max NDVI), and the human disturbance. Read More
Bull World Health Organ 2018 Oct 27;96(10):716-722. Epub 2018 Aug 27.
College of Health and Medicine, University of Tasmania, 17 Liverpool St, Hobart, Tasmania 7000, Australia.
Problem: Violent conflict left Timor-Leste with a dismantled health-care workforce and infrastructure after 2001. The absence of existing health and tertiary education sectors compounded the challenges of instituting a national eye-care system.
Approach: From 2001, the East Timor Eye Program coordinated donations and initially provided eye care through visiting teams. Read More
Vet Rec 2018 Dec 19;183(22):691. Epub 2018 Nov 19.
Animal Welfare Science and Education Department, Royal New Zealand SPCA National Office, Auckland, New Zealand.
This descriptive study explored how end-of-life management was taught to students in all eight Australasian veterinary schools. A questionnaire-style interview guide was used by a representative at each university to conduct structured interviews with educators in a snowball sampling approach. Four categories of animals were addressed: livestock, equine, companion and avian/wildlife. Read More
Neuromodulation 2018 Nov 19. Epub 2018 Nov 19.
Faculty of Medical and Health Sciences, Department of Surgery, The University of Auckland, Auckland, New Zealand.
Objectives: Postoperative ileus occurs in approximately 5-15% of patients following major abdominal surgery, and poses a substantial clinical and economic burden. Electrical stimulation has been proposed as a means to aid postoperative gastrointestinal (GI) recovery, but no methods have entered routine clinical practice. A systematic review was undertaken to assess electrical stimulation techniques and to evaluate their clinical efficacy in order to identify promising areas for future research. Read More
Public Health Nutr 2018 Nov 15:1-15. Epub 2018 Nov 15.
7Danone Nutricia Research, R.D. 128 Avenue de la Vauve, 91767 Palaiseau Cedex,France.
Objective: A wide variety of methods are available to assess dietary intake, each one with different strengths and weaknesses. Researchers face multiple challenges when diet and nutrition need to be accurately assessed, particularly in the selection of the most appropriate dietary assessment method for their study. The goal of the current collaborative work is to present a collection of available resources for dietary assessment implementation. Read More
Emerg Med Australas 2018 Nov 14. Epub 2018 Nov 14.
Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
In the past 5 years Botswana graduated its first home-grown doctors and emergency medicine specialists for the country. The postgraduate emergency medicine specialist training arrangement between Botswana and South Africa was challenging in development, implementation and maintenance. Numerous varied supports from ACEM and its International Emergency Medicine Network were integral to these successes. Read More
Transpl Int 2018 Nov 14. Epub 2018 Nov 14.
Centre for Transplant and Renal Research, Westmead Hospital, Sydney, NSW, Australia.
Weekend surgery may be associated with a higher risk of early complications, but the effect of the timing of kidney transplant surgery on early allograft outcome remains uncertain. The aim of this study is to evaluate whether the association between weekend transplant surgery and allograft failure was modified by prevalent vascular disease. Using data from the Australia and New Zealand Dialysis and Transplant registry, we examined the association between weekend status and 90-day and 1-year allograft failure in deceased donor transplant recipients between 1994-2012. Read More
Br J Cancer 2018 Nov 13;119(11):1332-1338. Epub 2018 Nov 13.
Cancer Research UK Clinical Trials Unit, Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.
Background: The Short Course Oncology Therapy (SCOT) study is an international, multicentre, non-inferiority randomised controlled trial assessing the efficacy, toxicity, and cost-effectiveness of 3 months (3 M) versus the usually given 6 months (6 M) of adjuvant chemotherapy in colorectal cancer.
Methods: In total, 6088 patients with fully resected high-risk stage II or stage III colorectal cancer were randomised and followed up for 3-8 years. The within-trial cost-effectiveness analysis from a UK health-care perspective is presented using the resource use data, quality of life (EQ-5D-3L), time on treatment (ToT), disease-free survival after treatment (DFS) and overall survival (OS) data. Read More
ANZ J Surg 2018 Nov 9. Epub 2018 Nov 9.
Department of Paediatric Surgery, Canterbury District Health Board, Christchurch, New Zealand.
Nutr J 2018 Nov 9;17(1):104. Epub 2018 Nov 9.
Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, 3220, Australia.
Background: Despite the health benefits of regular vegetable and legume consumption, on average Australians are consuming only half of the recommended daily intake. The reasons for this low consumption are complex, and are particularly driven by societal shifts towards convenient and ready-to-eat meal options. It is currently unknown how legumes and vegetables are being utilised in food products within the Australian context, and the nutritional value or level of processing of these products. Read More
J Fish Dis 2018 Nov 8. Epub 2018 Nov 8.
Murdoch University School of Veterinary and Life Sciences, Perth, WA, Australia.
A total of 777 fish from three growing regions of New Zealand Chinook salmon farms comprising of five sites were tested. Quantitative PCR was used to determine the distribution of New Zealand rickettsia-like organism and Tenacibaculum maritimum. Genetic information from these bacteria were then compared with strains reported worldwide. Read More
Science 2018 Dec 8;362(6419). Epub 2018 Nov 8.
Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, 1350 Copenhagen, Denmark.
Studies of the peopling of the Americas have focused on the timing and number of initial migrations. Less attention has been paid to the subsequent spread of people within the Americas. We sequenced 15 ancient human genomes spanning from Alaska to Patagonia; six are ≥10,000 years old (up to ~18× coverage). Read More
Ultrasound Med Biol 2018 Nov 5. Epub 2018 Nov 5.
World Federation for Ultrasound in Medicine and Biology (WFUMB), Chicago, Illinois, USA; Department of Obstetrics & Gynecology, University of Chicago, Chicago, Illinois, USA.
As ultrasound technology rapidly evolves and is used more frequently in every area of medical diagnosis and treatment, it may be overlooked as a potential vector in the transmission of a health care-associated infection. A survey on disinfection and hygiene practice in medical ultrasound was disseminated via the World Federation for Ultrasound in Medicine and Biology (WFUMB) to its six member federations and associated ultrasound societies globally. One thousand twenty-nine responses were obtained across a broad range of ultrasound practitioners. Read More
J Med Imaging Radiat Oncol 2018 Dec 8;62(6):789-793. Epub 2018 Nov 8.
Ormiston Orthopaedics, Auckland, New Zealand.
Introduction: To report a series of patients with osteoid osteoma treated by radiofrequency ablation in whom no complications or recurrences occurred.
Methods: Over a 13-year period, 32 consecutive patients with osteoid osteoma were treated by radiofrequency ablation in an Australasian teaching centre.
Results: All patients had resolution of symptoms with no complication or recurrence. Read More
Bull Emerg Trauma 2018 Oct;6(4):329-333
Department of Emergency Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Objective: To evaluate the validity, reliability, sensitivity, and specificity of the Emergency Severity Index (ESI) and Australasian Triage System (ATS) for children visiting admitted to the emergency department (ED).
Methods: This was a prospective study occurred in the Mofid children's Hospital in Iran from August 2017 to November 2018 and children had aged ≤14 years and presented at the ED with a medical symptom were considered eligible for participation. This study was divided into two phases: in the first phase, we determined the inter-rater reliability of ESI version 4 and ATS by triage nurses and pediatric residents. Read More
Sci Data 2018 Nov 6;5:180220. Epub 2018 Nov 6.
Department of Biomedical Sciences, College of Medicine, Korea University, Seoul 02841, Korea.
Sarcophaga peregrina (flesh fly) is a frequently found fly species in Palaearctic, Oriental, and Australasian regions that can be used to estimate minimal postmortem intervals important for forensic investigations. Despite its forensic importance, the genome information of S. peregrina has not been fully described. Read More
Australas J Dermatol 2018 Nov;59(4):352
Australasian Journal of Dermatology.
Virus Evol 2018 Jul 31;4(2):vey031. Epub 2018 Oct 31.
Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, The University of Sydney, Sydney, Australia.
Aquaculture is the fastest growing industry worldwide. Aquatic diseases have had enormous economic and environmental impacts in the recent past and the emergence of new aquatic pathogens, particularly viruses, poses a continuous threat. Nevertheless, little is known about the diversity, abundance and evolution of fish viruses. Read More
Australas Phys Eng Sci Med 2018 Nov 2. Epub 2018 Nov 2.
Chris O'Brien Lifehouse, Camperdown, NSW, Australia.
A survey was designed to determine aspirations, motivations and workplace experiences of both female and male members of the Australasian College of Physical Scientists and Engineers in Medicine (ACPSEM). The survey collected both quantitate and qualitative data, including open ended questions. This paper reports the survey's qualitative results. Read More
Intern Med J 2018 Nov;48(11):1404-1407
Department of Medicine, Sydney Medical School, Sydney, New South Wales, Australia.
Dr James L. T. Isbister (JLT), a graduate of the University of Adelaide, came to Sydney as a clinical pathologist at Sydney Hospital in 1897 and subsequently was a general practitioner in North Sydney and honorary surgeon and gynaecologist at Royal North Shore Hospital from 1900. Read More
Asian-Australas J Anim Sci 2018 Nov 23;31(11):1840-1841. Epub 2018 Oct 23.
Asian-Australasian Journal of Animal Sciences, Seoul 08776, Korea.
Shock 2018 Oct 30. Epub 2018 Oct 30.
Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Introduction: To describe the utilization of vasopressors (VP) in patients enrolled in the Australasian Resuscitation In Sepsis Evaluation (ARISE) trial, and to explore the association between time to VP and 90-day mortality.
Methods: The primary exposure variable was VP use after arrival in the emergency department (ED). Vasoactive agents considered as VP included: norepinephrine, epinephrine, metaraminol, or vasopressin. Read More
Australas Psychiatry 2018 Oct 31:1039856218810156. Epub 2018 Oct 31.
Professor of Psychiatry, the University of Melbourne, Melbourne, VIC, and; Chair of Psychiatry, St Vincent's Health, Melbourne, VIC, Australia.
Objective:: There are increasing demands on emergency psychiatrists with higher numbers of mental health presentations, and longer stays in emergency departments (EDs). Australia, like other English speaking countries, funds considerably lower numbers of psychiatric beds than average for Organisation for Economic Co-operation and Development (OECD) countries. Consequently, acute bed occupancy is high, and a bed is frequently unavailable when a person needs admission. Read More
Dermatol Ther 2018 Nov 30;31(6):e12727. Epub 2018 Oct 30.
Dermatology and Pathology, Rutgers New Jersey Medical School, Newark, New Jersey.
Mol Ecol 2018 Oct 30. Epub 2018 Oct 30.
College of Science and Engineering, Australian Tropical Herbarium, Centre for Tropical Environmental and Sustainability Science, James Cook University, Cairns, Queensland, Australia.
Organisms that are highly connected in food webs often perform unique and vital functions within ecosystems. Understanding the unique ecological roles played by highly connected organisms and the consequences of their loss requires a comprehensive understanding of the functional redundancy amongst organisms. One important, yet poorly understood, food web is that between truffle-forming ectomycorrhizal fungi and their mammalian consumers and dispersers. Read More
J Med Radiat Sci 2018 Dec 28;65(4):267-274. Epub 2018 Oct 28.
Science and Engineering Faculty, Queensland University of Technology, Brisbane, Queensland, Australia.
Introduction: The objectives of this study were to identify knowledge gaps and/or perceived limitations in the performance of paediatric appendiceal ultrasound by Australasian sonographers. We hypothesised that: sonographers' confidence in visualising the appendix in children was poor, particularly outside predominantly paediatric practice; workplace support for prolonging examinations to improve visualisation was limited; and the sonographic criteria applied in diagnosis did not reflect contemporary literature.
Methods: A cross-sectional survey of Australasian sonographers regarding paediatric appendicitis was conducted using a mixed methods approach (quantitative and qualitative data). Read More
Palliat Med 2018 Oct 29:269216318809668. Epub 2018 Oct 29.
1 Victorian Paediatric Palliative Care Program, Royal Children's Hospital, Melbourne, VIC, Australia.
Background:: Distressing and potentially life-threatening events, such as significant external bleeding, may occur in patients with a known terminal condition. These events are often referred to as catastrophic or crisis events. Pharmacological management varies and there is little evidence to guide practice. Read More
Australas Phys Eng Sci Med 2018 Dec;41(4):781-808
Genesis Cancer Care Queensland, Level 8 Premion Place, 39 White Street, Southport, QLD, 4125, Australia.
The Australasian College of Physical Scientists and Engineers in Medicine (ACPSEM) Radiation Oncology Specialty Group (ROSG) formed a series of working groups to develop recommendations for guidance of radiation oncology medical physics practice within the Australasian setting. These recommendations provide a standard for safe work practices and quality control. It is the responsibility of the medical physicist to ensure that locally available equipment and procedures are sufficiently sensitive to establish compliance. Read More
BMJ 2018 Oct 25;363:k4438. Epub 2018 Oct 25.
Australasian College for Emergency Medicine, Melbourne, Australia.
Menopause 2018 Nov;25(11):1362-1387
The 2017 Hormone Therapy Position Statement of The North American Menopause Society (NAMS) updates the 2012 Hormone Therapy Position Statement of The North American Menopause Society and identifies future research needs. An Advisory Panel of clinicians and researchers expert in the field of women's health and menopause was recruited by NAMS to review the 2012 Position Statement, evaluate new literature, assess the evidence, and reach consensus on recommendations, using the level of evidence to identify the strength of recommendations and the quality of the evidence. The Panel's recommendations were reviewed and approved by the NAMS Board of Trustees. Read More
Sci Rep 2018 Oct 23;8(1):15646. Epub 2018 Oct 23.
Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore, 129801, Singapore.
Leaf warblers (Aves; Phylloscopidae) are a diverse clade of insectivorous, canopy-dwelling songbirds widespread across the Old World. The taxonomy of Australasian leaf warblers is particularly complex, with multiple species-level divergences between island taxa in the region requiring further scrutiny. We use a combination of morphology, bioacoustics, and analysis of thousands of genome-wide markers to investigate and describe a new species of Phylloscopus leaf warbler from the island of Rote in the Lesser Sundas, Indonesia. Read More
Interv Neuroradiol 2018 Oct 23:1591019918800457. Epub 2018 Oct 23.
39 University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada.
Plast Reconstr Surg Glob Open 2018 Sep 5;6(9):e1878. Epub 2018 Sep 5.
Dutch Breast Implant Registry (DBIR), The Netherlands.
Background: The mission of the International Confederation of Plastic Surgery Societies (ICOPLAST) is to improve patient outcomes through collaboratively structured processes in education, advocacy and communication. This article explains how we approached the task of establishing priorities for this nascent confederation in an equitable and achievable manner.
Methods: In late 2016, an online survey was sent to the inaugural 62 ICOPLAST member national societies for dissemination to their respective plastic surgeon members. Read More
J Gastroenterol Hepatol 2018 Oct 21. Epub 2018 Oct 21.
Gastroenterological Society of Australia (GESA), Melbourne, Victoria, Australia.
Outbreaks of carbapenemase-producing Enterobacteriaceae clinical infections related to endoscopic transmission are well documented. The high morbidity and mortality associated with these infections emphasizes the need to reassess endoscopic reprocessing protocols. The Gastroenterological Society of Australia established a multi-society committee to formulate evidence-based consensus statements on the prevention and management of endoscopic transmission of carbapenemase-producing Enterobacteriaceae. Read More
Lancet HIV 2018 Nov 17;5(11):e629-e637. Epub 2018 Oct 17.
The Kirby Institute, University of New South Wales, Sydney, NSW, Australia.
Background: HIV pre-exposure prophylaxis (PrEP) is highly effective in men who have sex with men (MSM) at the individual level, but data on population-level impact are lacking. We examined whether rapid, targeted, and high-coverage roll-out of PrEP in an MSM epidemic would reduce HIV incidence in the cohort prescribed PrEP and state-wide in Australia's most populous state, New South Wales.
Methods: The Expanded PrEP Implementation in Communities-New South Wales (EPIC-NSW) study is an implementation cohort study of daily co-formulated tenofovir disoproxil fumarate and emtricitabine as HIV PrEP. Read More
Forensic Sci Int 2018 Nov 6;292:e25-e30. Epub 2018 Oct 6.
Ecology and Evolutionary Biology Section, School of Biological Sciences, University of Reading, Whiteknights Campus, Reading RG6 6AS, United Kingdom. Electronic address:
This study reports for the first time the use of soil micro-invertebrates, mites, as trace evidence to localise buried objects such as money. The case relates to a crime in Germany, where a large sum of banknotes had been hidden in an unknown location, likely abroad. In 2016, part of the money (approx. Read More
Obes Surg 2018 Oct 17. Epub 2018 Oct 17.
Fellow of the Royal Australasian College of Physicians (FRACP), Senior Lecturer at the Rural Clinical School, University of Melbourne, Northeast Health Wangaratta, Wangaratta, Australia.
Obesity is a global epidemic. Obesity in those with type I diabetes (T1DM) contributes to poor glycemic control and complications. Bariatric surgery as management for obesity is increasing in those with T1DM. Read More
Transpl Int 2018 Oct 13. Epub 2018 Oct 13.
Westmead Institute for Medical Research, Westmead, NSW, Australia.
Skeletal Radiol 2018 Oct 13. Epub 2018 Oct 13.
Queensland X-Ray, Brisbane, Australia.
Leukemia 2018 Oct 12. Epub 2018 Oct 12.
Cancer Theme, South Australian Health & Medical Research Institute, Adelaide, Australia.
Following the achievement of deep molecular response on tyrosine kinase inhibitors (TKIs), approximately half of patients with chronic myeloid leukemia (CML) can discontinue TKI and remain in treatment-free remission (TFR). The ALLG CML8 study enrolled 40 imatinib-treated patients with undetectable BCR-ABL1 mRNA (approximately MR). Molecular relapse was defined as detectable BCR-ABL1 on two consecutive tests or any single value >0. Read More