183,438 results match your criteria Auris Nasus Larynx [Journal]


The Value of Unilateral CIs, CI-CROS and Bilateral CIs, with and without Beamformer Microphones, for Speech Understanding in a Simulation of a Restaurant Environment.

Audiol Neurootol 2018 Dec 11;23(5):270-276. Epub 2018 Dec 11.

Advanced Bionics, Valencia, California, USA.

Objective: Our primary aim was to determine, in a simulation of a crowded restaurant, the value to speech understanding of (i) a unilateral cochlear implant (CI), (ii) a CI plus CROS (contralateral routing of signals) aid system and (iii) bilateral CIs when tested with and without beamforming microphones.

Design: The listeners were 7 CI listeners who had used bilateral CIs for an average of 9 years. The listeners were tested with three device configurations (bilateral CI, unilateral CI + CROS, and unilateral CI), two signal processing conditions (without and with beamformers) and with speech either from +90°, -90°, or from the front. Read More

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December 2018

Comparison of Pure-Tone Average Methods for Estimation of Hearing Loss Caused by Environmental Exposure to Lead and Cadmium: Does the Pure-Tone Average Method Which Uses Low-Frequency Ranges Underestimate the Actual Hearing Loss Caused by Environmental Lead and Cadmium Exposure?

Audiol Neurootol 2018 Dec 11;23(5):259-269. Epub 2018 Dec 11.

BK21 PLUS Program in Embodiment: Health-Society Interaction, Department of Public Health Sciences, Graduate School, Korea University, Seoul, Republic of Korea.

Previous studies have reported that exposure to lead and cadmium can damage the inner ear receptor, which perceives high-frequency sounds. However, few studies have used the pure-tone average (PTA), including high-frequency ranges, for the estimation of hearing loss caused by lead and cadmium exposure. We estimated hearing loss using the PTA test, in low-frequency, speech frequency, and high-frequency ranges and compared the differences in the results using 3 PTA calculation methods. Read More

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December 2018

Investigation of efficiency of a novel, zinc oxide loaded TEMPO-oxidized cellulose nanofiber based hemostat for topical bleeding.

Int J Biol Macromol 2018 Dec 8. Epub 2018 Dec 8.

Department of Regenerative Medicine, College of Medicine, Soonchunhyang University Cheonan-31151, Republic of Korea; Institute of Tissue Regeneration, College of Medicine, Soonchunhyang University 366-1, Cheonan 31151, Republic of Korea. Electronic address:

Lethal bleeding due to street accidents, natural calamities, orthopedic/dental surgeries, organ transplantation and household injuries, is the leading cause of morbidity and mortality. In the current study, zinc oxide (ZnO) was incorporated in TEMPO-oxidized cellulose nanofiber (TOCN) and polyethylene glycol (PEG) polymer system for hemorrhage control by freeze drying method. SEM and XRD data showed the presence of ZnO in the porous structure. Read More

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December 2018
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GNAQ Mutations in Diffuse and Solitary Choroidal Hemangiomas.

Ophthalmology 2018 Dec 8. Epub 2018 Dec 8.

Memorial Sloan-Kettering Cancer Center, New York, NY; Weill Cornell Medical Center, New York, NY.

Purpose: GNAQ mutations have been identified in port wine stains (both syndromic and non-syndromic) and melanocytic ocular neoplasms. This study investigates the presence of GNAQ mutations in diffuse- (those associated with Sturge-Weber syndrome (SWS)) and solitary choroidal hemangiomas.

Participants: Tissue from 11 patients with the following diagnoses: port wine stain (n = 3), diffuse choroidal hemangioma (n = 1), solitary choroidal hemangioma (n = 6), choroidal nevus (n =1) METHODS: Ten specimens were interrogated with Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT), a hybridization capture-based next-generation sequencing assay for targeted deep sequencing of all exons and selected introns of 468 key cancer genes in formalin-fixed, paraffin-embedded tumors. Read More

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December 2018
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Osteitis is associated with dysregulated pro-osteoblastic activity in patients with nasal polyps.

Laryngoscope 2018 Dec 11. Epub 2018 Dec 11.

From the Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, U.S.A.

Objectives/hypothesis: The overlying inflammatory mucosa plays a crucial role in the initiation of osteitis; however, the molecular mechanism is unclear. The objective of this study was to explore the bone morphogenetic protein (BMP) pathway and to correlate the expression of key signaling molecules with the degree of osteitis in patients with chronic rhinosinusitis with nasal polyps (CRSwNP).

Study Design: Prospective experimental analysis. Read More

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December 2018

Arachnoid cysts of the internal auditory canal: An underappreciated entity?

Laryngoscope 2018 Dec 8. Epub 2018 Dec 8.

Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, U.S.A.

Objectives/hypothesis: To describe the histopathologic findings and clinical presentation of arachnoid cysts (ACs) within the human temporal bone.

Study Design: Retrospective cohort analysis.

Methods: An analysis of all medical records of patients diagnosed with an AC was performed. Read More

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December 2018

CLIP-170 spatially modulates receptor tyrosine kinase recycling to coordinate cell migration.

Traffic 2018 Dec 7. Epub 2018 Dec 7.

Department of Biochemistry, McGill University, Quebec, Canada.

Endocytic sorting of activated receptor tyrosine kinases (RTKs), alternating between recycling and degradative processes, controls signal duration, location, and surface complement of RTKs. The Microtubule (MT) plus-end tracking proteins (+TIPs) play essential roles in various cellular activities including translocation of intracellular cargo. However, mechanisms through which RTKs recycle back to the plasma membrane following internalisation in response to ligand remain poorly understood. Read More

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December 2018
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Otopathology in Angiosarcoma of the Temporal Bone.

Laryngoscope 2018 Dec 11. Epub 2018 Dec 11.

Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts.

Objectives/hypothesis: Investigate the otopathology of angiosarcoma of the temporal bone, which has not been previously described in the literature.

Study Design: Postmortem evaluation and literature review.

Methods: Postmortem histological evaluation of the temporal bones and review of the literature for the treatment and prognosis of this rare disease were performed. Read More

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December 2018

Wait times for endoscopic sinus surgery influence patient-reported outcome measures in patients with chronic rhinosinusitis who fulfill appropriateness criteria.

Int Forum Allergy Rhinol 2018 Dec 10. Epub 2018 Dec 10.

Division of Rhinology, Department of Otolaryngology-Head and Neck Surgery, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.

Background: Previous studies on the impact of wait times for endoscopic sinus surgery (ESS) in medically recalcitrant chronic rhinosinusitis (rCRS) have not examined its influence on the 5 distinct symptoms domains of the 22-item Sino-Nasal Outcome Test (SNOT-22), and have not applied evidence-based surgical indications. Our primary study objective was to investigate the impact of ESS wait times on postoperative SNOT-22 global and symptom domain scores in patients with rCRS deemed "appropriate" surgical candidates.

Methods: This was a retrospective analysis of adult patients with rCRS undergoing ESS, categorized as "appropriate" surgical candidates. Read More

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December 2018

Venous thromboembolism in head and neck surgery: Risk, outcome, and burden at the national level.

Head Neck 2018 Dec 7. Epub 2018 Dec 7.

Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana.

Background: Venous thromboembolism (VTE) can complicate major surgeries. This study examines the risk and outcomes of VTE in patients who underwent head and neck surgeries.

Methods: Retrospective cross-sectional analysis utilizing the Nationwide Readmissions Database (2010-2014). Read More

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December 2018

Ototoxicity in locally advanced head and neck cancer patients treated with induction chemotherapy followed by intermediate or high-dose cisplatin-based chemoradiotherapy.

Head Neck 2018 Dec 7. Epub 2018 Dec 7.

Department of Medical Oncology, Radboud University Medical Center, Nijmegen, The Netherlands.

Background: This study evaluated ototoxicity in locally advanced head and neck cancer patients treated in the CONDOR study with docetaxel/cisplatin/5-fluorouracil (TPF) followed by conventional radiotherapy with concomitant cisplatin 100 mg/m on days 1, 22, and 43 (cis100+RT) versus accelerated radiotherapy with concomitant cisplatin weekly 40 mg/m (cis40+ART).

Methods: Sixty-two patients were treated in this study. Audiometry was performed at baseline, during TPF, before start of chemoradiotherapy, and 1, 4, 8, and 12 months after treatment. Read More

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December 2018

Overview of antibody-mediated immunity to S. pneumoniae: pneumococcal infections, pneumococcal immunity assessment, and recommendations for IG product evaluation.

Transfusion 2018 Dec;58 Suppl 3:3106-3113

Regional Immunology Service, The Royal Hospitals, Belfast Health & Social Care Trust and Queen's University Belfast, Belfast, UK.

Streptococcus pneumoniae (S. pneumoniae) strains colonize the nasopharynx and can cause mucosal infections in the upper airway and middle ear, pneumonias, and invasive infections like bacteremia, sepsis, and meningitis. Over 90 serotypes, defined by the structure of their capsular polysaccharides, are known. Read More

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December 2018

[Management of vestibular schwannomas].

Laryngorhinootologie 2018 Dec 10;97(12):875-896. Epub 2018 Dec 10.

Vestibular schwannomas are benign neoplasms originating from the Schwann cells of the vestibular vestibular nerve of the vestibulocochlear nerve, and rarely from the pars cochlearis. These are tumors that are in contact with the nerve but do not bind the fibers. Benign neoplasms of the Schwann cells of the auditory and equilibrium nerves can also occur primarily in the inner ear and are referred to as intralabyrinthine schwannomas (ILS). Read More

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December 2018

A modified method of local infiltration for endoscopic stapes surgery: how I do it.

Eur Arch Otorhinolaryngol 2018 Dec 10. Epub 2018 Dec 10.

Department of Otorhinolaryngology and Head Neck Surgery, UMAE, IMSS, Guadalajara, Jalisco, Mexico.

Purpose: To present a modified method of local infiltration (MMLI) for endoscopic stapes surgery to reduce surgical time, bleeding and complications.

Materials And Methods: This study involved 70 patients who underwent stapes surgery for otosclerosis by endoscopic and microscopic approaches. The MMLI was applied as follows: local infiltration was performed with one hand while the other hand inserted the endoscope into the ear canal to observe vasoconstriction signs on the monitor; the single site of infiltration was located at the center of the anterior conchal cartilage. Read More

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December 2018
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Incidental findings on 18-FDG PET-CT in head and neck cancer. A retrospective case-control study of incidental findings on 18-FDG PET-CT in patients with head and neck cancer.

Eur Arch Otorhinolaryngol 2018 Dec 10. Epub 2018 Dec 10.

Department of Ear, Nose, and Throat Surgery, Oxford University Hospital NHS Foundation Trust, Oxford, UK.

Purpose: Use of 18-FDG PET-CT is increasing in patients with head and neck cancer, enabling the identification of metastases or synchronous malignancies, but also 'incidental' disease. We aimed to establish the rate of 'incidental' findings resulting from 18-FDG PET-specific imaging, that would not have been otherwise identified on other imaging, in patients with head and neck cancer undergoing staging or surveillance of disease.

Methods: 18-FDG PET-CT was performed for investigation or surveillance. Read More

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December 2018

Establishment of a novel and effective reflux laryngitis model in rabbits: a preliminary study.

Eur Arch Otorhinolaryngol 2018 Dec 10. Epub 2018 Dec 10.

The Department of Otolaryngology-Head and Neck Surgery, Eye, Ear, Nose, and Throat Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200030, China.

Purpose: To establish a novel and effective reflux model with a modified nasogastric aspiration tube and to investigate the association between different types of nasogastric aspiration tubes and reflux laryngitis, we conducted this study.

Methods: Thirty-eight healthy New Zealand albino rabbits (2.5-3. Read More

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December 2018

Effects of crystalloids and colloids on microcirculation, central venous oxygen saturation, and central venous-to-arterial carbon dioxide gap in a rabbit model of hemorrhagic shock.

J Anesth 2018 Dec 10. Epub 2018 Dec 10.

Department of Cardiovascular Surgery, Tokyo Women's Medical University, 8-1, Kawadacho Shinjuku-ku, Tokyo, 162-8666, Japan.

Objective: The effects of hydroxyethyl starch (HES) on microcirculation, central venous oxygen saturation (ScvO), and the central venous-to-arterial carbon dioxide gap (dCO) are studied in a rabbit model of hemorrhagic shock for elucidating the advantages and drawbacks of resuscitation with HES compared with crystalloids.

Methods: An ear chamber and sublingual mucosa were used to examine blood vessels by intravital microscopy. Hemorrhagic shock was induced by removing nearly half of the blood volume. Read More

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December 2018

Identification of phosphorylation proteins in response to water deficit during wheat flag leaf and grain development.

Bot Stud 2018 Dec 8;59(1):28. Epub 2018 Dec 8.

College of Life Science, Capital Normal University, Beijing, 100048, China.

Background: Wheat (Triticum aestivum L.) serves as important grain crop widely cultivated in the world, which is often suffered by drought stress in natural conditions. As one of the most important post translation modifications, protein phosphorylation widely participates in plant abiotic stress regulation. Read More

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December 2018

De novo and inherited loss-of-function variants of ATP2B2 are associated with rapidly progressive hearing impairment.

Hum Genet 2018 Dec 8. Epub 2018 Dec 8.

Hearing and Genes, Department of Otorhinolaryngology, Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.

ATP2B2 encodes the PMCA2 Ca pump that plays an important role in maintaining ion homeostasis in hair cells among others by extrusion of Ca from the stereocilia to the endolymph. Several mouse models have been described for this gene; mice heterozygous for loss-of-function defects display a rapidly progressive high-frequency hearing impairment. Up to now ATP2B2 has only been reported as a modifier, or in a digenic mechanism with CDH23 for hearing impairment in humans. Read More

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December 2018

Genetic analysis of cob resistance to F. verticillioides: another step towards the protection of maize from ear rot.

Theor Appl Genet 2018 Dec 10. Epub 2018 Dec 10.

College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.

Key Message: We lay the foundation for further research on maize resistance to Fusarium verticillioides cob rot by identifying a candidate resistance gene. Fusarium verticillioides ear rot is the most common type of maize ear rot in the Huanghuaihai Plain of China. Ear rot resistance includes cob and kernel resistance. Read More

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December 2018

Wide diameter bone-anchored hearing system implants: a comparison of long-term follow-up data between tissue reduction and tissue preservation techniques.

Eur Arch Otorhinolaryngol 2018 Dec 7. Epub 2018 Dec 7.

Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen, Denmark.

Objective: To present long-term data on the Wide Ponto implant bone-anchored hearing system (BAHS) in regards to implant stability, soft tissue reaction and implant loss for two case series undergone either the tissue reduction- or the tissue preservation surgical technique.

Methods: Comparison of two consecutive, prospective case series. Each case series enrolled 24 patients. Read More

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December 2018

MicroRNA‑143‑3p suppresses cell growth and invasion in laryngeal squamous cell carcinoma via targeting the k‑Ras/Raf/MEK/ERK signaling pathway.

Authors:
Feng Zhang Hua Cao

Int J Oncol 2018 Dec 6. Epub 2018 Dec 6.

Ear Nose and Throat Hospital, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.

MicroRNAs (miRNAs or miRs) have been identified as an important regulator in carcinogenesis and other pathological processes. However, the molecular mechanism underlying the function of miRNAs in the progression and development of laryngeal squamous cell carcinoma (LSCC) remains to be fully elucidated. In the present study, the miRNA expression pattern in LSCC tissues was profiled using miRNA microarray analysis. Read More

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December 2018

Facial Soft-tissue Mobility: Baseline Dynamics of Patients with Unilateral Facial Paralysis.

Plast Reconstr Surg Glob Open 2018 Oct 4;6(10):e1955. Epub 2018 Oct 4.

Department of Orthodontics, Tufts University School of Dental Medicine, Boston, Mass.

Background: The aims of this observational study were 2-fold: (1) To demonstrate a method and measures to quantify impaired facial soft-tissue movements in patients with facial paralysis; and (2) To quantify the differences in magnitude and velocity of facial soft-tissue movements between patients with facial paralysis and control participants.

Methods: The study sample that addressed both aims consisted of 20 adults with acute, unilateral, flaccid facial paralysis who presented at the onset of their paralysis, and a control group of 20 healthy adults. Dynamic 3D facial movement data were collected from each participant during 11 facial animations. Read More

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October 2018

Cuticular drusen associated with aneurysmal type 1 neovascularization (polypoidal choroidal vasculopathy).

Int J Retina Vitreous 2018 5;4:44. Epub 2018 Dec 5.

1Vitreous Retina Macula Consultants of New York, 460 Park Ave., New York, NY 10022 USA.

Background: Aneurysmal type 1 neovascularization (AT1) is a term recently introduced to better describe the aneurysmal dilatation that may arise from neovascular lesions, more commonly known as polypoidal choroidal vasculopathy. The proposed term, AT1, includes an expanded clinical spectrum of aneurysmal (polypoidal) lesions observed in both different ethnicities and associated with varied clinical phenotypes.

Case Presentation: A 61-year-old woman of European descent was referred for a new, asymptomatic retinal hemorrhage found on routine examination. Read More

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December 2018

Osteogenic Induction of Wharton's Jelly-Derived Mesenchymal Stem Cell for Bone Regeneration: A Systematic Review.

Stem Cells Int 2018 11;2018:2406462. Epub 2018 Nov 11.

Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, 56000 Cheras, Kuala Lumpur, Malaysia.

Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) are emerging as a promising source for bone regeneration in the treatment of bone defects. Previous studies have reported the ability of WJ-MSCs to be induced into the osteogenic lineage. The purpose of this review was to systematically assess the potential of WJ-MSC differentiation into the osteogenic lineage. Read More

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November 2018

Sleep EEG Derived From Behind-the-Ear Electrodes (cEEGrid) Compared to Standard Polysomnography: A Proof of Concept Study.

Front Hum Neurosci 2018 26;12:452. Epub 2018 Nov 26.

Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom.

Electroencephalography (EEG) recordings represent a vital component of the assessment of sleep physiology, but the methodology presently used is costly, intrusive to participants, and laborious in application. There is a recognized need to develop more easily applicable yet reliable EEG systems that allow unobtrusive long-term recording of sleep-wake EEG ideally away from the laboratory setting. cEEGrid is a recently developed flex-printed around-the-ear electrode array, which holds great potential for sleep-wake monitoring research. Read More

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November 2018

Maintenance of the Anatomic Contours in Auricular Reconstruction: The Button Technique.

J Cutan Aesthet Surg 2018 Jul-Sep;11(3):150-152

AboutSkin Dermatology and DermSurgery, Denver, Colorado, USA.

Background And Objective: Reconstructing the contours of the auricle is a unique challenge. Various bolster techniques have been tried to help prevent complications such as hematoma, seroma, and morbidity. Here, we describe a simple technique using a button to maintain the natural ear contour when it is at risk of a poor aesthetic outcome. Read More

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December 2018

Magnetic Resonance Imaging Artifacts and Cochlear Implant Positioning at 1.5 T In Vivo.

Biomed Res Int 2018 8;2018:9163285. Epub 2018 Nov 8.

Department of Otolaryngology, Head and Neck Surgery, Department of Radiology, Unfallkrankenhaus Berlin, Germany.

Objective: Cerebral magnetic resonance imaging with the magnet of the cochlear implant receiver/stimulator in place causes artifacts and hinders evaluation of intracerebral structures. The aim of this study was to evaluate the internal auditory canal and the labyrinth in a 1.5T MRI with the magnet in place. Read More

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November 2018

Barriers to and enablers of the implementation of an ICF-based intake tool in clinical otology and audiology practice-A qualitative pre-implementation study.

PLoS One 2018 11;13(12):e0208797. Epub 2018 Dec 11.

Amsterdam UMC, Vrije Universiteit Amsterdam, Otolaryngology-Head and Neck Surgery, Ear & Hearing, Amsterdam Public Health, De Boelelaan, Amsterdam, Netherlands.

The authors are developing an intake tool based on the Brief International Classification of Functioning Disability and Health Core Set for Hearing Loss, by operationalizing its categories into a Patient Reported Outcome Measure. This study was aimed at identifying enablers and barriers to using this tool as perceived by hearing health professionals (HHPs) and patients. Focus groups and interviews were held with HHPs (ENT surgeons, N = 14; audiologists, N = 8) and patients (N = 18). Read More

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December 2018

Auditory Nomenclature: Combining Name Recognition With Anatomical Description.

Front Neuroanat 2018 23;12:99. Epub 2018 Nov 23.

Department of Biology, The University of Iowa, Iowa City, IA, United States.

The inner ear and its two subsystems, the vestibular and the auditory system, exemplify how the identification of distinct cellular or anatomical elements ahead of elucidating their function, leads to a medley of anatomically defined and recognition oriented names that confused generations of students. Past attempts to clarify this unyielding nomenclature had incomplete success, as they could not yet generate an explanatory nomenclature. Building on these past efforts, we propose a somewhat revised nomenclature that keeps most of the past nomenclature as proposed and follows a simple rule: Anatomical and explanatory terms are combined followed, in brackets, by the name of the discoverer (see Table 1). Read More

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November 2018

The Inner Ear Heat Shock Transcriptional Signature Identifies Compounds That Protect Against Aminoglycoside Ototoxicity.

Front Cell Neurosci 2018 23;12:445. Epub 2018 Nov 23.

Section on Sensory Cell Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, United States.

Mechanosensory hair cells of the inner ear transduce auditory and vestibular sensory input. Hair cells are susceptible to death from a variety of stressors, including treatment with therapeutic drugs that have ototoxic side effects. There is a need for co-therapies to mitigate drug-induced ototoxicity, and we showed previously that induction of heat shock proteins (HSPs) protects against hair cell death and hearing loss caused by aminoglycoside antibiotics in mouse. Read More

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November 2018

Hands-on teaching, shadowing, and supported learning through acute clinics to help improve the confidence of and meet training needs for junior doctors working in ear, nose, and throat surgery.

Adv Med Educ Pract 2018 14;9:827-835. Epub 2018 Nov 14.

Department of ENT Surgery, Luton and Dunstable University Hospital, Luton, UK,

Background: Ear, nose, and throat (ENT) surgery is a niche and unique specialty that has been recognized as being poorly taught throughout medical school and postgraduate training. Junior doctors who rotate into this specialty often find it hard and struggle to manage patients. The aim of this study was to devise a junior doctor-focused induction program with specific emphasis on shadowing and partnered working to improve confidence and competence. Read More

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November 2018

Regional anesthesia to ameliorate postoperative analgesia outcomes in pediatric surgical patients: an updated systematic review of randomized controlled trials.

Local Reg Anesth 2018 15;11:91-109. Epub 2018 Nov 15.

Department of Anesthesiology, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI, USA,

Regional anesthesia is becoming increasingly popular among anesthesiologists in the management of postoperative analgesia following pediatric surgery. The main objective of this review was to systematically evaluate the last 5 years of randomized controlled trials on the role of regional anesthesia techniques in alleviating postoperative pain associated with various pediatric surgical procedures. Forty studies on 2,408 pediatric patients were evaluated. Read More

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November 2018

A666-conjugated nanoparticles target prestin of outer hair cells preventing cisplatin-induced hearing loss.

Int J Nanomedicine 2018 14;13:7517-7531. Epub 2018 Nov 14.

Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China,

Background: The delivery of treatment agents to inner ear with drug delivery system (DDS) has been under investigation to overcome the limitations of the conventional therapeutic agents in curing or alleviating the cisplatin ototoxicity.

Methods: In the present study, a novel targeted dexamethasone (DEX)-loaded DDS, A666-DEX-NP, was constructed for prevention from cisplatin-induced hearing loss. A666-(CLEPRWGFGWWLH) peptides specifically bind to prestin, which is limited to the outer hair cells (OHCs). Read More

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November 2018

Author Correction: Genomic analysis of a large set of currently-and historically-important human adenovirus pathogens.

Emerg Microbes Infect 2018 Dec 8;7(1):208. Epub 2018 Dec 8.

Bioinformatics and Computational Biology Program, School of Systems Biology, George Mason University, Manassas, VA, 20110, USA.

The original publication of this article [1] was missing the below author that made contributions to the research and the published article. Read More

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December 2018

Evaluation of Coupling Efficiency in Round Window Vibroplasty With a New Handheld Probe.

Otol Neurotol 2019 Jan;40(1):e40-e47

Department of Otorhinolaryngology Head and Neck Surgery, Medical Faculty, University of Cologne, Cologne, Germany.

Hypothesis: A handheld measuring probe was developed that analyzes the vibration characteristics of the stapes footplate after backward stimulation of the cochlea in round window vibroplasty. In temporal bone experiments, the measuring accuracy of the probe was tested.

Background: In round window vibroplasty, the effectiveness of the transmitted vibrations into the inner ear is provided with limited visual and tactile information. Read More

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January 2019

Perioperative Recording of Cochlear Implant Evoked Brain Stem Responses After Removal of the Intralabyrinthine Portion of a Vestibular Schwannoma in a Patient with NF2.

Otol Neurotol 2019 Jan;40(1):e20-e24

Department of Otorhinolaryngology, Head and Neck Surgery, Martin Luther University Halle-Wittenberg, University Medicine Halle, Germany.

Objective: To predict and optimize hearing outcomes with a cochlear implant (CI) in patients with intracochlear schwannoma and neurofibromatosis type 2 (NF2).

Patient: A patient with NF2 and bilateral deafness.

Interventions: The intracochlear portion of a vestibular schwannoma was removed with a partial cochleoectomy. Read More

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January 2019

Otopathology of Unilateral Cochlear Implantation in Patients With Bilateral Temporal Bone Fracture.

Otol Neurotol 2019 Jan;40(1):e14-e19

Department of Otolaryngology, Massachusetts Eye and Ear Infirmary.

Objective: Audiometric outcomes following cochlear implantation (CI) in patients with temporal bone fracture (TBF) are variable and the pathophysiology is not well understood. Herein, we describe otopathologic findings in two such cases to provide insight into pathophysiology and outcomes.

Patients: Two patients had a history of head trauma resulting in bilateral TBF and sudden, profound, sensorineural hearing loss. Read More

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January 2019

Naunton's Masking Dilemma Revisited.

Otol Neurotol 2019 Jan;40(1):e1-e6

Macquarie University, Sydney, Australia.

Background: Pure-tone audiometry is essential in diagnosing clinical hearing loss. Masking of the nontest ear is mandatory for determining accurate hearing thresholds in the presence of asymmetrical levels between the two ears and for ascertaining the presence of a conductive hearing loss. Paradoxically, over masking occurs when the intensity of the required masking noise to the contralateral ear is such that it exceeds interaural cranial attenuation by an amount sufficient to mask the test ear. Read More

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January 2019

The Occipital Artery Based Fascial Flap for Ear Reconstruction.

Plast Reconstr Surg 2018 Nov 26. Epub 2018 Nov 26.

Division of Plastic and Reconstructive Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, CA Department of Pediatric Plastic Surgery, Wilhelmina Children's Hospital, University Medical Center Utrecht, Heidelberglaan 100 3584 CX Utrecht Cedars Sinai Hospital, Los Angeles, CA Division of Plastic and Reconstructive Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, CA.

Background: The temporoparietal fascia (TPF) flap is frequently used in ear reconstruction. When the TPF is unavailable, options for primary or secondary salvage reconstruction are limited. In these patients, an inferiorly based occipital artery fascia (OCF) transpositional flap is a good alternative for soft tissue coverage over a framework. Read More

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November 2018

Medical Referral Patterns and Etiologies for Children With Mild-to-Severe Hearing Loss.

Ear Hear 2018 Dec 6. Epub 2018 Dec 6.

Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.

Objectives: To (1) identify the etiologies and risk factors of the patient cohort and determine the degree to which they reflected the incidence for children with hearing loss and (2) quantify practice management patterns in three catchment areas of the United States with available centers of excellence in pediatric hearing loss.

Design: Medical information for 307 children with bilateral, mild-to-severe hearing loss was examined retrospectively. Children were participants in the Outcomes of Children with Hearing Loss (OCHL) study, a 5-year longitudinal study that recruited subjects at three different sites. Read More

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December 2018

How Do You Deal With Uncertainty? Cochlear Implant Users Differ in the Dynamics of Lexical Processing of Noncanonical Inputs.

Ear Hear 2018 Dec 6. Epub 2018 Dec 6.

Department of Psychological and Brain Sciences, University of Iowa, Iowa City, Iowa, USA.

Objectives: Work in normal-hearing (NH) adults suggests that spoken language processing involves coping with ambiguity. Even a clearly spoken word contains brief periods of ambiguity as it unfolds over time, and early portions will not be sufficient to uniquely identify the word. However, beyond this temporary ambiguity, NH listeners must also cope with the loss of information due to reduced forms, dialect, and other factors. Read More

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December 2018

Development of the Cochlear Implant Quality of Life Item Bank.

Ear Hear 2018 Dec 6. Epub 2018 Dec 6.

Department of Otolaryngology-Head and Neck Surgery.

Objectives: Functional outcomes following cochlear implantation have traditionally been focused on word and sentence recognition, which, although important, do not capture the varied communication and other experiences of adult cochlear implant (CI) users. Although the inadequacies of speech recognition to quantify CI user benefits are widely acknowledged, rarely have adult CI user outcomes been comprehensively assessed beyond these conventional measures. An important limitation in addressing this knowledge gap is that patient-reported outcome measures have not been developed and validated in adult CI patients using rigorous scientific methods. Read More

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December 2018

Emerging roles for insulin-like growth factor binding protein like protein 1.

Neural Regen Res 2019 Feb;14(2):258-259

Schepens Eye Research Institute of Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.

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February 2019

Occurrence of and referral to specialists for pain-related diagnoses in First Nations and non-First Nations children and youth.

CMAJ 2018 Dec;190(49):E1434-E1440

Faculty of Health (Latimer), Dalhousie University; Centre for Pediatric Pain Research (Latimer, MacLeod, Sylliboy, Filiaggi, Finley), IWK Health Centre, Halifax, NS; Department of Integrated Studies (Sylliboy), McGill University, Montréal, Que.; Eskasoni Health Centre (Rudderham), Eskasoni, NS; Departments of Surgery (Lethbridge) and Anesthesia, Pain Management and Perioperative Medicine (Finley), and School of Physiotherapy (Harman), Dalhousie University, Halifax, NS.

Background: Indigenous youth have higher rates of chronic health conditions interfering with healthy development, including high rates of ear, dental, chest and musculoskeletal pain, as well as headache, arthritis and mental health issues. This study explores differences in pain-related diagnoses in First Nations and non-First Nations children.

Methods: Data from a study population of age- and sex-matched First Nations and non-First Nations children and youth were accessed from a specific region of Atlantic Canada. Read More

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December 2018

The Fungal Cyp51 Specific Inhibitor VT-1598 Demonstrates and Activity against .

Antimicrob Agents Chemother 2018 Dec 10. Epub 2018 Dec 10.

University of Texas Health Science Center at San Antonio, San Antonio, TX.

is an emerging pathogen associated with significant mortality and often multi-drug resistance. VT-1598, a tetrazole-based fungal CYP51-specific inhibitor, was evaluated and against Susceptibility testing was performed against 100 clinical isolates of by broth microdilution. Neutropenic mice were infected intravenously with , and treatment began 24 hours post-inoculation with vehicle control, oral VT-1598 (5, 15, and 50 mg/kg once daily), oral fluconazole (20 mg/kg once daily), or intraperitoneal caspofungin (10 mg/kg once daily), which continued for 7 days. Read More

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December 2018

Microvascular networks in the area of the auditory peripheral nervous system.

Hear Res 2018 Dec 4;371:105-116. Epub 2018 Dec 4.

Oregon Hearing Research Center, Department of Otolaryngology / Head & Neck Surgery, Oregon Health & Science University, Portland, OR, 97239, USA. Electronic address:

Using transgenic fluorescent reporter mice in combination with an established tissue clearing method, we detail heretofore optically opaque regions of the spiral lamina and spiral limbus where the auditory peripheral nervous system is located and provide insight into changes in cochlear vascular density with ageing. We found a relatively dense and branched vascular network in young adults, but a less dense and thinned network in aged adults. Significant reduction in vascular density starts early at the age of 180 days in the region of the spiral limbus (SL) and continues into old age at 540 days. Read More

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December 2018

Noise-induced trauma produces a temporal pattern of change in blood levels of the outer hair cell biomarker prestin.

Hear Res 2018 Nov 30;371:98-104. Epub 2018 Nov 30.

Sensorion, 375 Rue Du Professeur Blayac, 34080, Montpellier, France.

Biomarkers in easy-to-access body fluid compartments, such as blood, are commonly used to assess health of various organ systems in clinical medicine. At present, no such biomarkers are available to inform on the health of the inner ear. Previously, we proposed the outer-hair-cell-specific protein prestin, as a possible biomarker and provided proof of concept in noise- and cisplatin-induced hearing loss. Read More

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November 2018