999,630 results match your criteria Auditing-a Journal Of Practice & Theory[Journal]


Gastrointestinal involvement of primary skin diseases.

J Eur Acad Dermatol Venereol 2020 May 26. Epub 2020 May 26.

Center for Research & Development, Kaohsiung Municipal Siaogang Hospital, Kaohsiung, Taiwan.

Less is known about gastrointestinal (GI) involvement of primary skin diseases due to the difference in embryology, histology, microbiology and physiology between integument and alimentary tract. Esophagus, following the oropharyngeal mucosa, is the most common GI segment affected by primary skin diseases, especially by eosinophilic esophagitis, lichen planus, and autoimmune bullous dermatoses like pemphigus vulgaris, mucosal membrane pemphigoid and epidermolysis bullosa acquisita. Eosinophilic esophagitis is an emerging chronic atopic disease with esophageal dysfunction as the typical presentation, and esophageal narrowing, rings and stricture as late complications. Read More

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http://dx.doi.org/10.1111/jdv.16676DOI Listing

Risk of Bleeding with Exposure to Warfarin and Nonsteroidal Anti-Inflammatory Drugs: A Systematic Review and Meta-Analysis.

Thromb Haemost 2020 May 26. Epub 2020 May 26.

College of Pharmacy, L. S. Skaggs Research Institute, University of Utah, Salt Lake City, Utah, United States.

Background:  Warfarin use can trigger the occurrence of bleeding independently or as a result of a drug-drug interaction when used in combination with nonsteroidal anti-inflammatory drugs (NSAIDs).

Objectives:  This article examines the risk of bleeding in individuals exposed to concomitant warfarin and NSAID compared with those taking warfarin alone (Prospero Registry ID 145237).

Methods:  PubMed, EMBASE, Scopus, and Web of Science were searched. Read More

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http://dx.doi.org/10.1055/s-0040-1710592DOI Listing

Patient-reported outcome measures in systemic sclerosis-related interstitial lung disease for clinical practice and clinical trials.

J Scleroderma Relat Disord 2020 Mar 5;5(2 Suppl):48-60. Epub 2020 Mar 5.

National Heart and Lung Institute, Imperial College London, London, UK.

Systemic sclerosis (SSc) is a progressive vasculopathic, fibrosing autoimmune condition, portending significant mortality; wherein interstitial lung disease (ILD) is the leading cause of death. Although lacking a definitive cure, therapeutics for (SSc-ILD) that stave progression exist with further promising primary and adjuvant compounds in development, as well as interventions to reduce symptom burden and increase quality of life. To date, there has been a significant but varied history related to systemic sclerosis-related interstitial lung disease trial design and endpoint designation. Read More

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http://dx.doi.org/10.1177/2397198320904178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243660PMC

Analysis of diagnostic decision in acupuncture from the actual functional dyspepsia patient's clinical information.

Integr Med Res 2020 Dec 28;9(4):100419. Epub 2020 Apr 28.

Acupuncture and Meridian Science Research Center, Kyung Hee University, Seoul, South Korea.

Background: Clinical research in acupuncture has been criticized for not reflecting real-world practice in terms of diagnosis and intervention. This study aimed to collect data on the principles of diagnosis and selection of acupoints from Korean medicine doctors (KMDs) and analyze the patterns and priorities in decision-making.

Methods: The study design was based on the data of an actual patient with functional dyspepsia (FD) (according to Rome III criteria) to create simulated patients, and a KMD specialized in gastrointestinal disorders was allocated to collect the clinical information as objectively as possible. Read More

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http://dx.doi.org/10.1016/j.imr.2020.100419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236055PMC
December 2020

Current status of case reports and case series reported by Korean Medicine doctors in primary clinics: A systematic review.

Integr Med Res 2020 Dec 23;9(4):100417. Epub 2020 Apr 23.

Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea.

Background: This study aims to review the current quantity and quality of case reports and case series published by clinical doctors who worked in local Korean medicine clinics.

Methods: Seven electronic databases, one in English and six in Korean, were searched for case studies authored by clinically-based Korean Medicine doctors (KMDs) and published in academic journals between January 2000 and December 2018. The following data were extracted: the number of cases per article, authorship order, types of academic journals, the number of articles published in the domestic or international academic journals by publication year, citation counts, and classification of diseases. Read More

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http://dx.doi.org/10.1016/j.imr.2020.100417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236045PMC
December 2020

The therapeutic efficacy of Qigong exercise on the main symptoms of fibromyalgia: A pilot randomized clinical trial.

Integr Med Res 2020 Dec 25;9(4):100416. Epub 2020 Apr 25.

Department of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, Kansas City, KS, United States.

Background: Some of the most debilitating symptoms of fibromyalgia (FM) include widespread chronic pain, sleep disturbances, chronic fatigue, anxiety, and depression. Yet, there is a lack of effective self-management exercise interventions capable of alleviating FM symptoms. The objective of this study is to examine the efficacy of a 10-week daily Qigong, a mind-body intervention program, on FM symptoms. Read More

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http://dx.doi.org/10.1016/j.imr.2020.100416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235941PMC
December 2020

Outcomes, Microbiology and Antimicrobial Usage in Pressure Ulcer-Related Pelvic Osteomyelitis: Messages for Clinical Practice.

J Bone Jt Infect 2020 26;5(2):67-75. Epub 2020 Mar 26.

NHS Lothian Infection Service, Regional Infectious Diseases Unit, Western General Hospital, Edinburgh, U.K.

: Pressure ulcer-related pelvic osteomyelitis is a relatively under-studied entity in the field of bone infection. We sought to add to the limited evidence base for managing this challenging syndrome. : Cases were identified retrospectively from a surgical database and hospital discharge codes at a U. Read More

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http://dx.doi.org/10.7150/jbji.41779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242403PMC

Knowledge, Attitude, and Practices of Healthcare Workers Regarding the Use of Face Mask to Limit the Spread of the New Coronavirus Disease (COVID-19).

Cureus 2020 Apr 20;12(4):e7737. Epub 2020 Apr 20.

Orthopaedic Surgery, Dow University of Health Sciences, Karachi, PAK.

Introduction Many countries including Pakistan are currently using face masks in their pandemic control plans. Being highly prevalent, the correct use of these masks is particularly important, as an incorrect use and disposal may actually increase the rate of transmission. The purpose of this study was to investigate the knowledge, attitude, and practices of healthcare workers (HCWs) in wearing a surgical face mask to limit the spread of the new coronavirus disease 2019 (COVID-19). Read More

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http://dx.doi.org/10.7759/cureus.7737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241223PMC

Assessing Factors That Influence Healthcare Provider Attitudes and Practices regarding Place-Based Exercise Prescriptions: Results of Principal Components Analysis of a Newly Developed Survey Instrument.

Adv Prev Med 2020 11;2020:5084053. Epub 2020 May 11.

College of Public Health, Kent State University, Moulton Hall, 800 Hilltop Drive, Kent, OH 44242, USA.

Introduction: The purpose of this paper is to describe development and preliminary assessment of an instrument designed to assess facilitators and barriers of provider-provided, place-based exercise prescriptions, including provider attributes, perceptions, knowledge, and resource needs. Although the American Medical Association-Supported "Exercise is Medicine" initiative encourages the practice of exercise prescription among member providers, only a small proportion engages in this practice. Additionally, little is known about the role of place-based exercise prescriptions, although access to physical activity resources differs based on residence, access to transportation, income, and other factors. Read More

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http://dx.doi.org/10.1155/2020/5084053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238351PMC

Results of Ranibizumab Treatment of the Myopic Choroidal Neovascular Membrane according to the Axial Length of the Eye.

J Ophthalmol 2020 12;2020:3076596. Epub 2020 May 12.

Department of Ophthalmology, Faculty of Medicine in Hradec Kralove, Charles University in Prague and University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.

Aim: A retrospective evaluation of the results of treatment of myopic choroidal neovascularization (mCNV) with intravitreal injections of ranibizumab in a (PRN) regimen in three groups of patients distributed according to axial length.

Methods: The paper presents a retrospective multicenter study carried out with the cooperation of several Departments of Ophthalmology in the Czech Republic. The study included 60 eyes of 60 patients suffering from mCNV, divided according to axial length into three groups. Read More

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http://dx.doi.org/10.1155/2020/3076596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243022PMC

Current regulatory approaches for accessing potential COVID-19 therapies.

J Pharm Policy Pract 2020 16;13:16. Epub 2020 May 16.

1Faculty of Pharmacy, University Ss. Cyril and Methodius, Skopje, North Macedonia.

This commentary aims to elaborate challenges in the regulatory approaches for accessing and investigating COVID-19 potential therapies either with off-label use, compassionate use, emergency use or for clinical trials. Since no therapies have been formally approved and completely effective and safe to date, the best clinical choice is acquired only after consistent and fair communication and collaboration between licensed clinicians, researchers, regulatory authorities, manufacturers and patients. Read More

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http://dx.doi.org/10.1186/s40545-020-00222-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229878PMC

Feasibility and Effectiveness of Telephone-Based Telephysiotherapy for Treatment of Pain in Low-Resource Setting: A Retrospective Pre-Post Design.

Pain Res Manag 2020 8;2020:2741278. Epub 2020 May 8.

Department of Nursing, School of Medical Sciences, Kathmandu University, Dhulikhel, Nepal.

Introduction: Telephysiotherapy (TPT) is a provision of physiotherapy services at a distance, using telecommunication technology when an in-person visit is not a feasible option. The objective of this study was to investigate the effectiveness of TPT in management of pain caused due to various problems among patients living in rural areas of a developing country.

Methods: This retrospective study conducted in rural areas of Nepal recruited all patients who met the eligibility criteria during a day campaign. Read More

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http://dx.doi.org/10.1155/2020/2741278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231093PMC

Methylation in Nasopharyngeal Swabs: A Potential Minimally Invasive Biomarker for the Early Detection of Nasopharyngeal Carcinoma.

Dis Markers 2020 5;2020:7253531. Epub 2020 May 5.

Department of Otorhinolaryngology-Head and Neck Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China.

Nasopharyngeal carcinoma (NPC) is highly prevalent in Southeast Asia, and an unfavorable outcome is usually attributed to advanced stage NPC. Current methods for the early diagnosis of NPC have limitations in clinical practice. The aim of this study was to investigate the diagnostic ability of methylation for NPC. Read More

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http://dx.doi.org/10.1155/2020/7253531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232724PMC

Prognostic Value of Functional Assessment of Cancer Therapy-General (FACT-G) in Advanced Non-Small-Cell Lung Cancer Treated with Korean Medicine.

Evid Based Complement Alternat Med 2020 20;2020:2845401. Epub 2020 Jan 20.

Department of Clinical Oncology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.

Objectives: The impact of health-related quality of life (HRQoL) on survival has been investigated in patients with various cancers. Here, we evaluated the prognostic value of HRQoL using the Functional Assessment of Cancer Therapy-General (FACT-G) in advanced non-small-cell lung cancer (NSCLC) patients treated with Korean medicine.

Methods: A retrospective review of medical records and FACT-G scores of patients with advanced NSCLC who received treatment with Korean medicine was conducted. Read More

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http://dx.doi.org/10.1155/2020/2845401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212313PMC
January 2020

Comparative Pharmacokinetics of Geniposidic Acid, Genipin-1--Gentiobioside, Geniposide, Genipin, and Crocetin in Rats after Oral Administration of Crude and Its Three Processed Products Using LC-MS/MS.

Evid Based Complement Alternat Med 2020 6;2020:1642761. Epub 2020 May 6.

Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 300193 Tianjin, China.

The extract of (GF) with different processing methods processed the different medicinal properties and efficacy. Crude GF (CGF) could be processed into stir-frying GF (SGF), gancao mix-frying GF (GCGF), and ginger mix-frying GF (GIGF) in practice. An LC-MS/MS method was established for simultaneous quantification of geniposidic acid, geniposide, genipin-1--gentiobioside, genipin, and crocetin in the rat plasma. Read More

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http://dx.doi.org/10.1155/2020/1642761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229567PMC

Effect of Ketamine/Propofol Admixture on Peri-Induction Hemodynamics: A Systematic Review and Meta-Analysis.

Anesthesiol Res Pract 2020 8;2020:9637412. Epub 2020 May 8.

Evidence-Based Practice Center, Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.

To evaluate the effectiveness of an admixture of ketamine and propofol on peri-induction hemodynamics during airway manipulation, we searched electronic databases of randomized controlled trials from January 1, 2000, to October 17, 2018. Trial screening, selection, and data extraction were done independently by two reviewers with outcomes pooled across included trials using the random-effects model. We included 10 randomized trials (722 patients, mean age of 53. Read More

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http://dx.doi.org/10.1155/2020/9637412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231081PMC

Deposition Pattern of Polydisperse Dry Powders in Andersen Cascade Impactor - Aerodynamic Assessment for Inhalation Experimentally and .

Turk J Pharm Sci 2020 Feb 19;17(1):20-26. Epub 2020 Feb 19.

Prince of Songkla University, Faculty of Pharmaceutical Sciences, Department of Pharmaceutical Technology, Drug Delivery System Excellence Center, Hat Yai, Songkhla, Thailand.

Objectives: An impactor is a standard instrument that applied for particle deposition assessment in the pharmaceutical aerosols. It provides data comparison between inhaler formulations. However, the deposition pattern in the impactor is not clearly understood. Read More

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http://dx.doi.org/10.4274/tjps.galenos.2018.15870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227867PMC
February 2020

You Need a Plan: A Stepwise Protocol for Operating Room Preparedness During an Infectious Pandemic.

Fed Pract 2020 May;37(5):212-218

is an Anesthesiologist and Surgical Intensivist, is an Operating Room Registered Nurse Educator, is a Surgical Intensivist and Chief of General Surgery, and is an Anesthesiologist and Surgical Intensivist, all at VA Puget Sound Health Care System in Seattle, Washington. Vivek Arora and Alex Lee are affiliated with the Department of Anesthesiology and Pain Medicine and Lorrie Langdale is affiliated with the Department of Surgery, University of Washington in Seattle.

Background: The worldwide spread of SARS-CoV-2, the coronavirus that causes the syndrome designated COVID-19, presents a challenge for emergency operative management. The transmission and virulence of this new pathogen has raised concern for how best to protect operating room staff while effectively providing care to the infected patient requiring urgent or emergent surgery.

Observations: Establishment of a clear protocol that adheres to rigorous infection control measures while providing a safe system for interfacility transport and operative care is vital to a successful surgical pandemic response. Read More

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Time-Limited Trials in the Intensive Care Unit to Promote Goal-Concordant Patient Care.

Clin Pulm Med 2019 Sep;26(5):141-145

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Consider the hypothetical case of a 75-year-old patient admitted to the intensive care unit (ICU) for acute hypoxic respiratory failure due to pneumonia and systolic heart failure. Although she suffers from a potentially treatable infection, her advanced age and chronic illness increase her risk of experiencing a poor outcome. Her family feels conflicted about whether the use of mechanical ventilation would be acceptable given what they understand about her values and preferences. Read More

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http://dx.doi.org/10.1097/cpm.0000000000000323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243638PMC
September 2019

Diagnosis and Management of Graves' Disease in Thailand: A Survey of Current Practice.

J Thyroid Res 2020 11;2020:8175712. Epub 2020 May 11.

Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.

Background: The data on clinical practice patterns in the evaluation and management of Graves' disease (GD) are limited in Asia. The aims of this survey were to report the current practices in the management of GD in Thailand and to examine any international differences in the management of GD.

Methods: Members of the Endocrine Society of Thailand who were board certified in endocrinology ( = 392) were invited to participate in an electronic survey on the management of GD using the same index case and questionnaire as in previous North American and European surveys. Read More

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http://dx.doi.org/10.1155/2020/8175712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238361PMC

Electro-optical performance of nematic liquid crystals doped with gold nanoparticles.

J Phys Condens Matter 2020 May 26. Epub 2020 May 26.

Institute of General Physics named after A P Prokhorov Russian Academy of Sciences, Moscow, RUSSIAN FEDERATION.

The effect of gold nanoparticles on the dielectric, electro-optical, and rheological properties of the ZhK-1289 liquid-crystal mixture that define the response time of liquid-crystal devices with a concentration range of 0.06-5 wt% was investigated in this study. A phase diagram of the obtained composites was formed demonstrating an increase in the clearing temperature and a broadening of the mesophase existence range in the case of doping nanoparticles. Read More

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http://dx.doi.org/10.1088/1361-648X/ab966cDOI Listing

Measles is Back - Considerations for laboratory diagnosis.

J Clin Virol 2020 May 13;128:104430. Epub 2020 May 13.

Department of Infection, University College of London, London, UK; National Microbiology Services, NHS Blood and Transplant, London, UK.

Measles is a highly contagious viral illness that continues to cause significant mortality among young children worldwide despite the availability of a safe and effective vaccine. During the first half of 2019, over 182 countries reported more than 300,000 measles cases; greater than double the number from the same period in 2018. Timely recognition and laboratory confirmation of infected individuals as well as appropriate infection prevention measures are crucial to avert further transmission. Read More

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http://dx.doi.org/10.1016/j.jcv.2020.104430DOI Listing

ASL perfusion in acute ischemic stroke: The value of CBF in outcome prediction.

Clin Neurol Neurosurg 2020 May 19;194:105908. Epub 2020 May 19.

Department of Neuroradiology, University Hospital Pitié-Salpêtrière, APHP, 47 boulevard de l'hopital, 75651 Paris cedex 13, France; Sorbonnes Universités, Pierre and Marie Curie Faculty of Medicine, UPMC Univ Paris 06, UMR S 1127, CNRS UMR 7225, Paris, France. Electronic address:

Objective: The application of novel advanced magnetic resonance imaging (MRI) techniques in clinical practice has significantly improved diagnostic accuracy in early detection of acute ischemic stroke (AIS), additionally allowing outcome prediction. The introduction of arterial spin labeling (ASL) perfusion sequence as a standard in MRI protocols is a significant milestone in neuroradiology. The aim of the present study was to demonstrate the potential of ASL sequence for the detection of absolute (aCBF) and relative (rCBF) cerebral blood flow values for an ischemic area and to examine the correlation of the obtained values with the functional outcome of patients. Read More

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http://dx.doi.org/10.1016/j.clineuro.2020.105908DOI Listing

Web-based experiential learning strategies to enhance the evidence-based-practice competence of undergraduate nursing students.

Nurse Educ Today 2020 May 7;91:104466. Epub 2020 May 7.

Department of Nursing Services and Patient Care, University of Iowa Hospitals and Clinics, United States of America.

Background: Evidence-based practice (EBP) is considered a key competence for practicing high-quality and safe nursing. However, undergraduate nursing programs continue to provide traditional classroom teaching strategies that have limitations in facilitating the development of critical competences for engaging in EBP in real clinical contexts.

Objective And Design: The purpose of this study was to develop a web-based experiential learning program aimed at improving the engagement and experience of nursing students in EBP. Read More

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http://dx.doi.org/10.1016/j.nedt.2020.104466DOI Listing

Establishing psychological safety in simulation: Faculty perceptions.

Nurse Educ Today 2020 May 7;91:104468. Epub 2020 May 7.

University of the Fraser Valley, 45190 Caen Ave., Chilliwack, BC V2R 0N3, Canada. Electronic address:

Background: A psychologically safe learning environment is defined as one where individuals feel comfortable to take interpersonal risks without fear of negative consequences. Despite knowledge of best practice for simulation, there is a lack of knowledge regarding how nursing faculty perceive and establish psychological safety in a simulated learning environment.

Objectives: The purpose of this study was to explore nursing faculty's perceptions of psychological safety as it exists within a simulation learning environment for pre-licensure nursing students. Read More

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http://dx.doi.org/10.1016/j.nedt.2020.104468DOI Listing

Optimised cushioning in diabetic footwear can significantly enhance their capacity to reduce plantar pressure.

Gait Posture 2020 May 17;79:244-250. Epub 2020 May 17.

Centre for Biomechanics and Rehabilitation Technologies, Staffordshire University, Stoke-on-Trent, United Kingdom; Faculty of Health Sciences, University of Malta, Msida, Malta.

Background: Plantar pressure reduction with the use of cushioning materials play an important role in the clinical management of the diabetic foot. Previous studies in people without diabetes have shown that appropriate selection of the stiffness of such materials can significantly enhance their capacity to reduce pressure. However the significance of optimised cushioning has not been yet assessed for people with diabetic foot syndrome. Read More

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http://dx.doi.org/10.1016/j.gaitpost.2020.05.009DOI Listing

A Methodological Assessment of Lymphoedema Clinical Practice Guidelines.

J Vasc Surg Venous Lymphat Disord 2020 May 23. Epub 2020 May 23.

Department of Surgery & Cancer, Imperial College London, Charing Cross Hospital, London W6 8RF, United Kingdom. Electronic address:

Objectives: To determine the methodological quality of current lymphoedema clinical practice guidelines (CPGs) to assist healthcare professionals in selecting accessible, high-quality guidance and to identify areas for improvement in future CPGs.

Methods: Medline, EMBASE, online CPG databases and reference lists of included guidelines were searched up to 31st January 2020. Full-text CPGs reporting on evidence-based recommendations in lymphoedema diagnosis and/or management in English were included. Read More

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http://dx.doi.org/10.1016/j.jvsv.2020.05.004DOI Listing

Early Vascular Surgery Response to the COVID-19 Pandemic: Results of a Nationwide Survey.

J Vasc Surg 2020 May 23. Epub 2020 May 23.

Division of Vascular and Endovascular Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA. Electronic address:

Objectives: The COVID-19 pandemic has had major implications for the United States healthcare system. This survey study sought to identify practice changes, understand current personal protection equipment (PPE) use, and determine how caring for patients with COVID-19 differs for vascular surgeons practicing in states with high COVID-19 case numbers versus low case numbers.

Methods: A fourteen-question online survey regarding the effect of the COVID-19 pandemic on vascular surgeons' current practice was sent to 365 vascular surgeons across the country via REDCap from 4/14/2020 to 4/21/2020 with responses closed on 4/23/2020. Read More

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http://dx.doi.org/10.1016/j.jvs.2020.05.032DOI Listing

Experience from a Singapore tertiary hospital with restructuring a vascular surgery practice in response to national and institutional policies during the COVID-19 pandemic.

J Vasc Surg 2020 May 23. Epub 2020 May 23.

Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Division of Vascular and Endovascular Surgery, Department of Cardiac, Thoracic and Vascular Surgery, National University Heart Centre Singapore, Singapore; SingVaSC, Singapore Vascular Surgical Collaborative, Singapore.

Singapore was one of the first countries to be affected by COVID-19, with the index patient diagnosed on 23 January 2020. For two weeks in February, we had the highest number of COVID-19 cases behind China. In this article, we summarize the key national and institutional policies that were implemented in response to COVID-19. Read More

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http://dx.doi.org/10.1016/j.jvs.2020.05.026DOI Listing

Pediatric Neurosurgery in East Africa: An Education and Needs-Based Survey.

World Neurosurg 2020 May 23. Epub 2020 May 23.

Department of Neurosurgery, Northwestern University Feinberg School of Medicine; Lurie Children's Hospital, Chicago, IL, USA.

Introduction: A pediatric neurosurgery training workshop was organized for residents and consultants in East Africa. We aimed to compile feedback from course participants to: (i) characterize the state of neurosurgical education; and (ii) identify perceived practical education needs.

Methods: The survey of demographic, clinical background/practice, and feedback questions was distributed to all attendees. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.05.155DOI Listing

Laparoscopic technique for discoid resection of rectal endometriotic nodules.

J Minim Invasive Gynecol 2020 May 23. Epub 2020 May 23.

Endoscopica Malzoni, Center for Advanced Endoscopic Gynecologic Surgery, Avellino, Italy. Electronic address:

Objective: To show the surgical steps used to perform rectal disc excision in a context of deep infiltrating endometriosis characterized by contiguity between intestinal lesion and retrocervical region.

Design: Step-by-step video demonstration of the technique.

Setting: Although surgical options for the management of rectosigmoid endometriosis have increasingly been investigated, there is no consensus regarding patient eligibility for shaving, discoid or segmental resection. Read More

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http://dx.doi.org/10.1016/j.jmig.2020.05.016DOI Listing

Initial validation of the product of the signs global assessment and body surface area (SGAxBSA) in atopic dermatitis.

J Am Acad Dermatol 2020 May 23. Epub 2020 May 23.

Oregon Health & Science University, Department of Dermatology, Portland, OR. Electronic address:

Background: Current valid instruments that measure the signs of AD in clinical trials may not be suitable for clinical practice due to their complexity. The product of a clinician-derived 5-point signs global assessment and body surface area (SGAxBSA) may represent a simple approach to quickly assess the severity of signs in patients with AD in clinical practice.

Objectives: Evaluate the basic measurement properties of the SGAxBSA. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.05.095DOI Listing

VMAT2 inhibitors for the treatment of hyperkinetic movement disorders.

Pharmacol Ther 2020 May 23:107580. Epub 2020 May 23.

Neurology and Basic Sciences, Division of Movement Disorders, Department of Neurology, Loma Linda University School of Medicine, Faculty Medical Offices, 11370 Anderson, Suite B-100, Loma Linda, CA 92350, United States of America. Electronic address:

Hyperkinetic movement disorders comprise a variety of conditions characterized by involuntary movements, which include but are not limited to tardive dyskinesia, chorea associated with Huntington's Disease, and tic disorders. The class of medications that have been used to treat these conditions includes Vesicular Monoamine Transporter-2 (VMAT2) inhibitors. In 2008, the FDA approved tetrabenazine as a treatment for chorea associated with Huntington's Disease. Read More

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http://dx.doi.org/10.1016/j.pharmthera.2020.107580DOI Listing

The COVID-19 and Cancer Consortium: A Collaborative Effort to Understand the Effects of COVID-19 on Patients with Cancer.

Cancer Cell 2020 Apr 29. Epub 2020 Apr 29.

Department of Medical Oncology, Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address:

National and international consortia will play a key role in understanding the effects of the coronavirus disease 2019 (COVID-19) pandemic on cancer patients. The COVID-19 and Cancer Consortium (CCC19) aims to collect and analyze observational data at scale to inform clinical practice in real-time. Read More

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http://dx.doi.org/10.1016/j.ccell.2020.04.018DOI Listing

'…And how did that make you feel?' - GP trainees' perceptions of Balint on a local UK vocational training scheme.

Educ Prim Care 2020 May 26:1-9. Epub 2020 May 26.

NHS GP, Royal College of General Practitioners, London, UK.

Balint allows colleagues to explore emotions generated from doctor-patient interactions, complexities sometimes overlooked within traditional curricula. With an increasing burnout rate, evidence-based strategies to support trainee general practitioners (GPs) are needed and we investigated if Balint could be one way to improve this. There are no recent studies looking at Balint in UK GP training. Read More

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http://dx.doi.org/10.1080/14739879.2020.1764397DOI Listing

Subeschar culture using a punch instrument in unstageable wounds.

Arch Plast Surg 2020 May 15;47(3):228-234. Epub 2020 May 15.

Department of Plastic and Reconstructive Surgery, Daegu Catholic University School of Medicine, Daegu, Korea.

Background: A patient's overall condition sometimes does not allow for the complete removal of a dead eschar or injured slough in cases involving a pressure-injury skin lesion. This frequently occurs in clinical practice, particularly in bedridden and older patients receiving home care or intensive care. Even after debridement, it is also difficult to manage open exudative wounds in these patients. Read More

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http://dx.doi.org/10.5999/aps.2019.01641DOI Listing

Envisioning Distinctive Professional Identity for Critical Care Advanced Practice Providers: Fostering Integrative Transformation Beyond Orientation.

Pediatr Crit Care Med 2020 Mar 13. Epub 2020 Mar 13.

Section of Critical Care Medicine, Texas Children's Hospital, Houston, TX.

The roles played by nurse practitioners and physician assistants have expanded exponentially during the last decade. Although existing professional advancement models for nurse practitioners/physician assistants have led to enhanced integration in different patient care units, the development of a distinctive professional identity formation is lacking. This perspective proposes a new framework to guide the planning of an educational program that provides not only clinical knowledge and technical skills but also opportunities for enhancing leadership and research skills, along with strong career mentorship. Read More

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http://dx.doi.org/10.1097/PCC.0000000000002342DOI Listing

Methylene Blue for Refractory Shock in Children: A Systematic Review and Survey Practice Analysis.

Pediatr Crit Care Med 2020 Mar 13. Epub 2020 Mar 13.

Department of Pediatrics, Yale University, New Haven, CT.

Objectives: Shock refractory to fluid and catecholamine therapy has significant morbidity and mortality in children. The use of methylene blue to treat refractory shock in children is not well described. We aim to collect and summarize the literature and define physicians' practice patterns regarding the use of methylene blue to treat shock in children. Read More

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http://dx.doi.org/10.1097/PCC.0000000000002295DOI Listing

Re-assessment of the disk diffusion technique for routine antimicrobial susceptibility testing for Helicobacter pylori.

Helicobacter 2020 May 26:e12703. Epub 2020 May 26.

Division of Infectious Diseases, State Key Laboratory of Biotherapy, West China Marshall Research Center for Infectious Diseases, Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.

Background: The aim of this study was to assess the disk diffusion technique against E-test as a routine antibiotic susceptibility testing method for Helicobacter pylori.

Materials And Methods: Susceptibilities of 301 H pylori clinical isolates were simultaneously profiled by E-test and disk diffusion method for levofloxacin (5-μg disk), clarithromycin (15-μg disk), metronidazole (5-μg disk), amoxicillin (10-μg disk), and tetracycline (30-μg disk). Furazolidone susceptibility was evaluated using a 100-μg disk only. Read More

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http://dx.doi.org/10.1111/hel.12703DOI Listing

The impact of misclassification on covariate-adaptive randomized clinical trials.

Authors:
Tong Wang Wei Ma

Biometrics 2020 May 26. Epub 2020 May 26.

Institute of Statistics and Big Data, Renmin University of China, Beijing, China.

Covariate-adaptive randomization is widely used in clinical trials to balance treatment allocation over covariates. Over the past decade, significant progress has been made on the theoretical properties of covariate-adaptive design and associated inference. However, most results are established under the assumption that the covariates are correctly measured. Read More

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http://dx.doi.org/10.1111/biom.13308DOI Listing

Practice Patterns in the Surgical Management of Pediatric Traumatic Cataracts.

J Pediatr Ophthalmol Strabismus 2020 May;57(3):190-198

Purpose: To facilitate the development of standardized guidelines for the surgical management of patients with pediatric traumatic cataracts by assessing current ophthalmologists' practice patterns.

Methods: This was a cross-sectional, observational, and retrospective study. A 24-question electronic survey of current practices pertaining to the surgical management of pediatric traumatic cataracts was sent to pediatric ophthalmologists worldwide. Read More

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http://dx.doi.org/10.3928/01913913-20200304-01DOI Listing

Methodology for the American Society of Hematology VTE guidelines: current best practice, innovations, and experiences.

Blood Adv 2020 May;4(10):2351-2365

Michael G. DeGroote Cochrane Canada Centre.

Background: Methods for the development of clinical guidelines have advanced dramatically over the past 2 decades to strive for trustworthiness, transparency, user-friendliness, and rigor. The American Society of Hematology (ASH) guidelines on venous thromboembolism (VTE) have followed these advances, together with application of methodological innovations.

Objective: In this article, we describe methods and methodological innovations as a model to inform future guideline enterprises by ASH and others to achieve guideline standards. Read More

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http://dx.doi.org/10.1182/bloodadvances.2020001768DOI Listing

Tobacco control vs. e-cigarettes: the long-term liberal perspective.

Authors:
Kalle Grill

Nicotine Tob Res 2020 May 26. Epub 2020 May 26.

Department of Historical, Philosophical and Religious Studies, Umeå University.

The debate for and against making e-cigarettes available to smokers is largely empirical. We do not know the long-term health effects of vaping and we do not know how smokers will respond to e-cigarettes over time. In addition to these empirical uncertainties, however, there are difficult moral issues to consider. Read More

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http://dx.doi.org/10.1093/ntr/ntaa085DOI Listing

Systematic review of prediction models in relapsing remitting multiple sclerosis.

PLoS One 2020 26;15(5):e0233575. Epub 2020 May 26.

Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh, United Kingdom.

The natural history of relapsing remitting multiple sclerosis (RRMS) is variable and prediction of individual prognosis challenging. The inability to reliably predict prognosis at diagnosis has important implications for informed decision making especially in relation to disease modifying therapies. We conducted a systematic review in order to collate, describe and assess the methodological quality of published prediction models in RRMS. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233575PLOS

Informing children of their parent's illness: A systematic review of intervention programs with child outcomes in all health care settings globally from inception to 2019.

PLoS One 2020 26;15(5):e0233696. Epub 2020 May 26.

Academic Primary Health Care Center, Region Stockholm, Stockholm, Sweden.

Introduction: Children are impacted when parents are ill. This systematic review gives an overview of the current state of research and extracts what children and parents found helpful in the interventions aimed at informing children of their parent's illness.

Methods: This review was registered with PROSPERO and conducted in accordance with PRISMA guidelines. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233696PLOS

Effect of guided counseling on dietary practices of pregnant women in West Gojjam Zone, Ethiopia.

PLoS One 2020 26;15(5):e0233429. Epub 2020 May 26.

Department of Nutrition and Dietetics, Faculty of Public Health, Jimma University, Jimma, Ethiopia.

Background: In Ethiopia, although nutrition education has been given during pregnancy, most women have inadequate nutrient intakes. As a result, the prevalence of malnutrition is high during pregnancy. In this study, we set out to evaluate the effect of guided counseling based on the health belief model and the theory of planned behavior on the dietary practices of pregnant women. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233429PLOS

Onkológiai beteg tervezett PET/CT vizsgálata során véletlenszerűen felfedezett COVID-19-betegség.

Orv Hetil 2020 Jun;161(23):971-976

Általános Orvostudományi Kar, Orvosi Képalkotó Klinika, Nukleáris Medicina Tanszék,Semmelweis Egyetem Budapest, Korányi Sándor u. 2., 1083.

The scientific literature of coronavirus-disease 2019 (COVID-19) is rapidly expanding. There is a growing evidence on the discrepancy between clinical symptoms and radiologic findings in many patients. This case report gives details about a patient with only mild symptoms but relatively severe radiological findings. Read More

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http://dx.doi.org/10.1556/650.2020.31848DOI Listing
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