1,054 results match your criteria Audiology And Neuro-otology[Journal]


A Novel Cadherin 23 Variant for Hereditary Hearing Loss Reveals Additional Support for a DFNB12 Nonsyndromic Phenotype of CDH23.

Audiol Neurootol 2020 Jun 2:1-5. Epub 2020 Jun 2.

Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran,

Background And Objectives: Identification of the pathogenic mutations underlying hereditary hearing loss (HL) is difficult, since causative mutations in 60 different genes have so far been reported.

Methods: A comprehensive clinical and pedigree examination was performed on a multiplex family suffering from HL. Direct sequencing of GJB2 and genetic linkage analysis of 5 other most common recessive nonsyndromic HL (ARNSHL) genes were accomplished. Read More

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http://dx.doi.org/10.1159/000506500DOI Listing

Evaluation of Subtotal Petrosectomy Technique in Difficult Cases of Cochlear Implantation.

Audiol Neurootol 2020 May 29:1-13. Epub 2020 May 29.

Gruppo Otologico, Quaternary Referral Center for Otology, Neurotology and Skull Base Surgery, Piacenza, Italy.

Objectives: To assess the validity of the subtotal petrosectomy (STP) technique in problematic cases of cochlear implant (CI) surgery, and review indications, outcomes, and related controversies.

Study Design: This is a retrospective review of data from a private quaternary referral center of otology and skull base surgery.

Patients And Methods: A review of patients who underwent CI with STP (STP-CI) as the leading approach was performed. Read More

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http://dx.doi.org/10.1159/000507419DOI Listing

Eustachian Tube Function in Patients with Symptoms on Baro-Challenge.

Audiol Neurootol 2020 May 26:1-9. Epub 2020 May 26.

Cambridge Ear Institute, University of Cambridge, Cambridge, United Kingdom,

Objectives: To explore the relationship between aural symptoms during baro-challenge and the underlying measured Eustachian tube (ET) function. Two key questions were addressed. (1) In patients who have features of obstructive ET dysfunction, is there a measurable underlying difference in ET function between those who experience severe symptoms on baro-challenge and those that do not? (2) What is the diagnostic value of ET function tests in the identification of patients with severe symptoms on baro-challenge?

Methods: Patients with symptoms of obstructive ET dysfunction were recruited, with the presence of aural symptoms on baro-challenge established via the clinical history and analysis of the Cambridge ET Dysfunction Assessment, a patient-reported outcome measure (PROM). Read More

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http://dx.doi.org/10.1159/000505655DOI Listing

Binaural Interaction in Tinnitus Patients.

Audiol Neurootol 2020 May 13:1-8. Epub 2020 May 13.

Audiovestibular Unit, Faculty of Medicine, Tanta University, Tanta, Egypt,

The auditory brainstem response (ABR) is a commonly used objective clinical measure for hearing evaluation. It can be also used to draw conclusions about the functioning of distinct stages of the auditory pathway including the binaural processing stages using the binaural interaction component (BIC) of the ABR.

Objective: To study binaural processing in normal hearing subjects complaining of tinnitus. Read More

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http://dx.doi.org/10.1159/000507274DOI Listing

Comparing Light-Driven Contact Hearing Aids with Acoustic Hearing Aids: Data and Clinical Tips.

Audiol Neurootol 2020 May 13:1-8. Epub 2020 May 13.

Shohet Ear Associates, Newport Beach, California, USA.

Introduction: Contact hearing aids (CHA) offer potential advantages over conventional acoustic hearing aids (AHA) in terms of sound quality, reduced occlusion, and increased high-frequency gain. This study evaluates objective and subjective outcome data for CHA compared to AHA.

Methods: Clinical outcome data were retrospectively reviewed for patients wearing CHA. Read More

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http://dx.doi.org/10.1159/000507273DOI Listing

Biocompatibility and Therapeutic Effect of 3 Intra-Tympanic Drug Delivery Vehicles in Acute Acoustic Trauma.

Audiol Neurootol 2020 May 13:1-6. Epub 2020 May 13.

Department of Otorhinolaryngology - Head and Neck Surgery, Seoul National University Hospital, Seoul, Republic of Korea,

Introduction: The aim of this study was to assess the biocompatibility of several intra-tympanic (IT) drug delivery vehicles and to compare hearing outcomes.

Materials And Methods: After acute acoustic trauma, rats were treated with IT 10 mg/mL dexamethasone phosphate (D) and divided into the following groups for drug delivery: saline + D (n = 15), hyaluronic acid (HA) + D (n = 17), and methoxy polyethylene glycol-b-polycaprolactone block copolymer (MP) + D (n = 24).

Results: No inflammation was found in the saline + D or HA + D groups. Read More

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http://dx.doi.org/10.1159/000506535DOI Listing
May 2020
1.852 Impact Factor

Prognostic Value of a Test of Central Auditory Function in Conversion from Mild Cognitive Impairment to Dementia.

Audiol Neurootol 2020 May 8:1-7. Epub 2020 May 8.

Department of Hearing and Balance, Karolinska University Hospital, Stockholm, Sweden.

Background/objective: It has been suggested that central auditory processing dysfunction might precede the development of cognitive decline and Alzheimer's disease (AD). The Dichotic Digits Test (DDT) has been proposed as a test of central auditory function. Our objective was to evaluate the predictive capacity of the DDT in conversion from mild cognitive impairment (MCI) to dementia. Read More

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http://dx.doi.org/10.1159/000506621DOI Listing

Telmisartan Protects Auditory Hair Cells from Gentamicin-Induced Toxicity in vitro.

Audiol Neurootol 2020 May 5:1-12. Epub 2020 May 5.

Clinic for Otolaryngology, Head and Neck Surgery, University of Basel Hospital, Basel, Switzerland,

Background: Telmisartan is an angiotensin II receptor blocker that has pleiotropic effects and protective properties in different cell types. Moreover, telmisartan has also shown partial agonism on the peroxisome proliferator-activated receptor γ (PPAR-γ). Auditory hair cells (HCs) express PPAR-γ, and the protective role of PPAR-γ agonists on HCs has been shown. Read More

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http://dx.doi.org/10.1159/000506796DOI Listing

Event-Related Potential Evidence of Enhanced Visual Processing in Auditory-Associated Cortex in Adults with Hearing Loss.

Audiol Neurootol 2020 Apr 22:1-12. Epub 2020 Apr 22.

Department of Otolaryngology, Sun Yat-sen Memorial Hospital and Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, China,

Objective: The present study investigated the characteristics of visual processing in the auditory-associated cortex in adults with hearing loss using event-related potentials.

Methods: Ten subjects with bilateral postlingual hearing loss were recruited. Ten age- and sex-matched normal-hearing subjects were included as controls. Read More

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http://dx.doi.org/10.1159/000505608DOI Listing

Effect of Noise Exposure on 1,382 Metallurgical Workers in Periodic Audiometric Evaluation: A Cohort Study.

Audiol Neurootol 2020 Apr 21:1-6. Epub 2020 Apr 21.

Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.

Introduction: Noise-induced hearing loss is the most preventable cause of auditory impairment. Periodic audiometric evaluations are essential to monitor the hearing health of noise-exposed workers.

Objective: To compare the evolution of audiometric thresholds in the initial three evaluations at frequencies of 3, 4, and 6 kHz in groups of workers exposed or not to noise. Read More

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http://dx.doi.org/10.1159/000506894DOI Listing

Epidemiology and Seasonal Variation of Ménière's Disease: Data from a Population-Based Study.

Audiol Neurootol 2020 Apr 14:1-7. Epub 2020 Apr 14.

Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea,

Introduction: Ménière's disease (MD) is a disease of the inner ear. In Asian countries, there is one previous epidemiologic study that used a retrospective survey of a specific district. Previous studies have demonstrated that weather variables are strongly associated with symptom aggravation in MD. Read More

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http://dx.doi.org/10.1159/000506921DOI Listing

Bone Conduction Trial Device to Eliminate the Effect of Transcranial Attenuation: A Prospective Observational Study in Single-Sided Deaf Subjects.

Audiol Neurootol 2020 Apr 14:1-6. Epub 2020 Apr 14.

Department of Otorhinolaryngology, Head and Neck Surgery, Antwerp University Hospital, Antwerp, Belgium,

Objectives: The contact miniTM (CM) is a nonimplantable, digital bone conduction device (BCD) consisting of 2 isolated units: an electronic housing, including the microphone, and a vibrator housing. The study investigated whether the CM can be used as an alternative test device for a BCD trial in single-sided deaf (SSD) adults with the microphone placed at the SSD ear and the vibrator at the normal-hearing (NH) ear (i.e. Read More

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http://dx.doi.org/10.1159/000503844DOI Listing

Three-Year Follow-Up with the Bone Conduction Implant.

Audiol Neurootol 2020 Apr 8:1-13. Epub 2020 Apr 8.

Department of Otorhinolaryngology Head and Neck Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background: The bone conduction implant (BCI) is an active transcutaneous bone conduction device where the transducer has direct contact to the bone, and the skin is intact. Sixteen patients have been implanted with the BCI with a planned follow-up of 5 years. This study reports on hearing, quality of life, and objective measures up to 36 months of follow-up in 10 patients. Read More

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http://dx.doi.org/10.1159/000506588DOI Listing

Assessment of Hearing Aid Benefit Using Patient-Reported Outcomes and Audiologic Measures.

Audiol Neurootol 2020 Apr 2:1-9. Epub 2020 Apr 2.

Department of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.

Purpose: To determine the contributions to hearing aid benefit of patient-reported outcomes and audiologic measures.

Methods: Independent review was conducted on audiologic and patient-reported outcomes of hearing aid benefit collected in the course of a middle ear implant FDA clinical trial. Unaided and aided data were extracted from the preoperative profiles of 95 experienced hearing aid users, and the relationships between a patient-reported outcome and audiologic measures were assessed. Read More

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http://dx.doi.org/10.1159/000506666DOI Listing

Audiological Findings in Patients with Vestibular Migraine and Migraine: History of Migraine May Be a Cause of Low-Tone Sudden Sensorineural Hearing Loss.

Audiol Neurootol 2020 Mar 20:1-6. Epub 2020 Mar 20.

Department of Otolaryngology, Peking University People's Hospital, Beijing, China,

Introduction: The aim of this study was to investigate and compare the auditory findings in migraine, vestibular migraine (VM), and healthy controls.

Methods: Twenty-eight migraine patients (56 ears), 18 VM (36 ears), and 25 healthy controls (50 ears) were included. Audiometry, speech discrimination scores, distortion product optoacoustic emission (DPOAE), and auditory brainstem response were tested. Read More

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http://dx.doi.org/10.1159/000506147DOI Listing
March 2020
1.852 Impact Factor

Salt-Inducible Kinase 3 Haplotypes Associated with Noise-Induced Hearing Loss in Chinese Workers.

Audiol Neurootol 2020 Mar 3:1-9. Epub 2020 Mar 3.

Center for Global Health, China International Cooperation Center for Environment and Human Health, School of Public Health, Nanjing Medical University, Nanjing, China,

Introduction: Noise-induced hearing loss (NIHL) is a common occupational disease that represents an irreversible hearing damage to the auditory system. It has been identified as a complicated disease involving both environmental and genetic factors. More efforts need to be made to explore the genes associated with susceptibility to NIHL. Read More

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http://dx.doi.org/10.1159/000506066DOI Listing

One Step Closer towards a Reliable Tinnitus Pitch-Match Frequency Determination Using Repetitive Recursive Matching.

Audiol Neurootol 2020 Feb 27:1-10. Epub 2020 Feb 27.

Department of Otorhinolaryngology, Jena University Hospital, Jena, Germany,

Introduction: The determination of the tinnitus pitch-match (PM) frequency is not straightforward but an important audiological assessment recommended for clinical and research purposes. We evaluated repetitive recursive matching using an iPod-based matching procedure as a method to estimate a patient's PM frequency without audiometric equipment.

Methods: One hundred and seventeen patients with chronic tonal tinnitus (uni- and bilateral tinnitus) measured their tinnitus in 10 sessions using a self-administered automated iPod-based procedure comprising a recursive 2 interval forced-choice test. Read More

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http://dx.doi.org/10.1159/000505308DOI Listing
February 2020

Audiological Results with the SAMBA Audio Processor in Comparison to the Amadé for the Vibrant Soundbridge.

Audiol Neurootol 2020 25;25(3):164-172. Epub 2020 Feb 25.

Department of Otolaryngology, Hannover Medical School, Hannover, Germany,

Background: Since its introduction in 1996, the Vibrant Soundbridge (VSB) has been upgraded with several improved generations of processors. As all systems are compatible, implanted patients can benefit from new technologies by upgrading to the newest processor type available.

Objectives: The aim of this study was to compare the performance of the new (current) SAMBA processor with the previous Amadé processor. Read More

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http://dx.doi.org/10.1159/000506067DOI Listing
February 2020

Bone Mineral Density in Patients Suffering from Ménière's Disease.

Audiol Neurootol 2020 21;25(3):158-163. Epub 2020 Feb 21.

Unit of Otoneurology, Lin Medical Center, Haifa, Israel.

Introduction: Previous studies have reported an association between reduced bone mineral density and the occurrence of benign paroxysmal positional vertigo, balance impairment, and saccular dysfunction. Furthermore, the results of recent animal studies have raised the possibility that vestibular dysfunction could affect bone remodeling and bone mass. The goal of the study was to compare bone mineral density of patients suffering from definite Ménière's disease to that of a matched control group. Read More

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http://dx.doi.org/10.1159/000506039DOI Listing
February 2020

Hearing Aid Treatment in Patients with Mixed Hearing Loss. Part I: Expected Benefit and Limitations after Stapes Surgery.

Audiol Neurootol 2020 11;25(3):125-132. Epub 2020 Feb 11.

Cluster of Excellence Hearing4all, Hannover, Germany.

Objective: The purpose of the present study was to determine the fraction of patients with mixed hearing loss who can or cannot expect benefit from power hearing aids (HAs) after stapes surgery.

Design: The audiological outcome of 374 stapes surgeries was used to calculate the patients' individual postoperative requirements in terms of gain and output of HAs. These requirements were compared to the available gain and output provided by state-of-the-art power HAs at 0. Read More

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http://dx.doi.org/10.1159/000502994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265761PMC
February 2020

Cochlear Implantation in Patients with Chronic Suppurative Otitis Media: Surgical Outcomes and a Management Algorithm.

Audiol Neurootol 2020 4;25(3):151-157. Epub 2020 Feb 4.

Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Chungnam National University, Daejeon, Republic of Korea,

Background: Chronic suppurative otitis media (CSOM) was considered as a contraindication of cochlear implantation (CI) in the past. Recently, various surgical options have been adopted for CI in CSOM patients with showing a low complication rate.

Objectives: To evaluate surgical outcomes of CI in patients with CSOM and to propose a management algorithm for those patients. Read More

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http://dx.doi.org/10.1159/000505509DOI Listing
February 2020
1.852 Impact Factor

Effectiveness of Bone Conduction Stimulation Applied Directly to the Otic Capsule Measured at Promontory: Assessment in Cadavers.

Audiol Neurootol 2020 31;25(3):143-150. Epub 2020 Jan 31.

Department of Otorhinolaryngology Head and Neck Surgery, Medical University of Warsaw, Warsaw, Poland.

Introduction: The aims of this study included: (a) to develop a method of direct acoustic bone conduction (BC) stimulation applied directly to the otic capsule, (b) to investigate the effect of different stimulation sites on the promontory displacement amplitude, and (c) to find the best stimulation site (among 2 located directly on the otic capsule and 1 standard site approved for clinical use) that provides the greatest transmission of vibratory energy.

Methods: Measurements were performed on 9 cadaveric whole human heads. A commercial scanning laser Doppler vibrometer was used. Read More

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http://dx.doi.org/10.1159/000505607DOI Listing
January 2020

Hearing Aid Treatment for Patients with Mixed Hearing Loss. Part II: Speech Recognition in Comparison to Direct Acoustic Cochlear Stimulation.

Audiol Neurootol 2020 31;25(3):133-142. Epub 2020 Jan 31.

Cluster of Excellence Hearing4all, Hannover, Germany.

Background: The conventional therapy for severe mixed hearing loss is middle ear surgery combined with a power hearing aid. However, a substantial group of patients with severe mixed hearing loss cannot be treated adequately with today's state-of-the-art (SOTA) power hearing aids, as predicted by the accompanying part I of this publication, where we compared the available maximum power output (MPO) and gain from technical specifications to requirements for optimum benefit using a common fitting rule. Here, we intended to validate the theoretical assumptions from part I experimentally in a mixed hearing loss cohort fitted with SOTA power hearing aids. Read More

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http://dx.doi.org/10.1159/000504285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265759PMC
January 2020

Interactions between Auditory and Vestibular Modalities during Stimulation with a Combined Vestibular and Cochlear Prosthesis.

Audiol Neurootol 2020 22;25(1-2):96-108. Epub 2020 Jan 22.

Department of Otolaryngology, University of Washington, Seattle, Washington, USA.

Background: A combined vestibular and cochlear prosthesis may restore hearing and balance to patients who have lost both. To do so, the device should activate each sensory system independently.

Objectives: In this study, we quantify auditory and vestibular interactions during interleaved stimulation with a combined 16-channel cochlear and 6-channel vestibular prosthesis in human subjects with both hearing and vestibular loss. Read More

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http://dx.doi.org/10.1159/000503846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050683PMC
January 2020

Evaluation of Hearing Thresholds by Using a Mobile Application in Children with Otitis Media with Effusion.

Audiol Neurootol 2020 21;25(3):120-124. Epub 2020 Jan 21.

Department of Otorhinolaryngology, Health Science University, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey.

Objective: Otitis media with effusion (OME) is the most common cause of hearing loss in children. Early diagnosis is important as hearing loss affects speech and language development in children. The aim of this study was to compare conventional audiometry with the Android mobile operating system application Hearing TestTM in the evaluation of hearing thresholds in children with OME and to determine the accuracy and reliability of the mobile application. Read More

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http://dx.doi.org/10.1159/000505309DOI Listing
January 2020

New Concepts in Electrical Stimulation in Vestibular Dysfunction.

Authors:
Jeffrey P Harris

Audiol Neurootol 2020 14;25(1-2). Epub 2020 Jan 14.

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http://dx.doi.org/10.1159/000504284DOI Listing
January 2020

The Superiority of the Otolith System.

Audiol Neurootol 2020 10;25(1-2):35-41. Epub 2020 Jan 10.

Lab for Equilibrium Investigations and Aerospace, University of Antwerp, Antwerp, Belgium.

Background: The peripheral vestibular end organ is considered to consist of semi-circular canals (SCC) for detection of angular accelerations and the otoliths for detection of linear accelerations. However, otoliths being phylogenetically the oldest part of the vestibular sensory organs are involved in detection of all motions.

Summary: This study elaborates on this property of the otolith organ, as this concept can be of importance for the currently designed vestibular implant devices. Read More

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http://dx.doi.org/10.1159/000504595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050676PMC
January 2020

Correlation between High-Resolution Computed Tomography Scan Findings and Histological Findings in Human Vestibular End Organs and Surgical Implications.

Audiol Neurootol 2020 7;25(1-2):42-49. Epub 2020 Jan 7.

Otorhinolaryngology Department, University of Navarra Clinic, Pamplona, Spain.

Background: Histological study of vestibular end organs has been challenging due to the difficulty in preserving their structures for histological analysis and due to their complex geometry. Recently, radiology advances have allowed to deepen the study of the membranous labyrinth.

Summary: A review and analysis of surgical implications related to the anatomy of the vestibular end organ is performed. Read More

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http://dx.doi.org/10.1159/000504594DOI Listing
January 2020

Amplitude Modulated Noise for Tinnitus Suppression in Tonal and Noise-Like Tinnitus.

Audiol Neurootol 2019 6;24(6):309-321. Epub 2020 Jan 6.

Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany,

Background: The phenomenon of short-term tinnitus suppression by different forms of acoustic stimulation is referred to as residual inhibition (RI). RI can be triggered in the majority of tinnitus cases and was found to be depending on the used intensity, length or types of sounds. Past research already stressed the impact of noise stimulation as well as the superiority of amplitude modulated (AM) pure tones at the individual tinnitus frequency for RI in tonal tinnitus. Read More

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http://dx.doi.org/10.1159/000504593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959056PMC
January 2020

Cochlear Implantation with the CI512 and CI532 Precurved Electrode Arrays: One-Year Speech Recognition and Intraoperative Thresholds of Electrically Evoked Compound Action Potentials.

Audiol Neurootol 2019 17;24(6):299-308. Epub 2019 Dec 17.

Division of Ear, Nose and Throat, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.

Introduction: Precurved cochlear implant (CI) electrode arrays were developed in an attempt to improve the auditory outcome of cochlear implantation, which varies greatly. The recent CI532 (Cochlear Corp., Sydney, Australia) may offer further advantages as its electrode array is thinner than previous precurved CI electrode arrays. Read More

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http://dx.doi.org/10.1159/000504592DOI Listing
December 2019

Synergistic Ototoxicity of Gentamicin and Low-Dose Irradiation: Molecular Basis and Clinical Significance.

Audiol Neurootol 2020 13;25(3):111-119. Epub 2019 Dec 13.

Departments of Clinical Translational Research, Singapore General Hospital, Singapore, Singapore.

Background: Inner ear structures may be included in the radiation fields when irradiation is used to treat patients with head and neck cancers. These patients may also have concurrent infections that require gentamicin treatment. Radiation and gentamicin are both potentially ototoxic, and their combined use has been shown to result in synergistic ototoxicity in animals. Read More

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http://dx.doi.org/10.1159/000503133DOI Listing
December 2019

Treatment Outcome of Auditory and Frontal Dual-Site rTMS in Tinnitus Patients and Changes in Magnetoencephalographic Functional Connectivity after rTMS: Double-Blind Randomized Controlled Trial.

Audiol Neurootol 2019 12;24(6):293-298. Epub 2019 Dec 12.

Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea,

Background: Recently, the role of neural modulation in nonauditory cortices via repetitive transcranial magnetic stimulation (rTMS) for tinnitus control has been emphasized. It is now more compelling to consider these nonauditory cortices and the whole "tinnitus network" as targets for tinnitus treatment to achieve a better outcome.

Objective: We aimed to investigate the effects of active dual-site rTMS treatment in tinnitus reduction using a double-blind randomized controlled trial. Read More

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http://dx.doi.org/10.1159/000503134DOI Listing
December 2019
1.852 Impact Factor

Bilateral Vestibular Hypofunction in the Time of the Video Head Impulse Test.

Audiol Neurootol 2020 11;25(1-2):72-78. Epub 2019 Dec 11.

Department of Otorhinolaryngology, Clínica Universidad de Navarra, Pamplona, Spain.

Objectives: Bilateral vestibulopathy is a clinical syndrome in which laboratory testing plays a crucial diagnostic role. We aimed to establish the frequency of detection of that finding in a tertiary level hospital considering the new methods of laboratory vestibular examination nowadays in use, with respect to the conventional caloric and rotatory chair test approaches.

Design: Two similar time periods (5 years) were retrospectively evaluated, and the demographic, clinical data and test results from 4,576 patients were reviewed. Read More

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http://dx.doi.org/10.1159/000504286DOI Listing
December 2019

Chronic Electrical Stimulation of the Otolith Organ: Preliminary Results in Humans with Bilateral Vestibulopathy and Sensorineural Hearing Loss.

Audiol Neurootol 2020 4;25(1-2):79-90. Epub 2019 Dec 4.

Department of Otolaryngology, and Head and Neck Surgery, Complejo Hospitalario Universitario Insular Materno Infantil de Gran Canaria, Las Palmas, Spain.

Introduction: Bilateral vestibulopathy is an important cause of imbalance that is misdiagnosed. The clinical management of patients with bilateral vestibular loss remains difficult as there is no clear evidence for an effective treatment. In this paper, we try to analyze the effect of chronic electrical stimulation and adaptation to electrical stimulation of the vestibular system in humans when stimulating the otolith organ with a constant pulse train to mitigate imbalance due to bilateral vestibular dysfunction (BVD). Read More

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http://dx.doi.org/10.1159/000503600DOI Listing
December 2019

Effects of Glycerol Test on Resonance Frequency in Patients with Ménière's Disease.

Audiol Neurootol 2019 12;24(6):285-292. Epub 2019 Nov 12.

Department of Otolaryngology, Faculty of Medicine, Baskent University, Ankara, Turkey.

Objective: To evaluate resonance frequency (RF) values via dehydration effects in the inner ear caused by the glycerol test, which is used as a diagnostic method for Ménière's disease (MD).

Methods: Twenty adult patients with unilateral MD were included in the study. Before, and then at 1, 2, and 3 h after administration of glycerol (1 g/kg), pure-tone hearing levels (125-8,000 kHz) and multifrequency tympanometry tests were performed. Read More

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http://dx.doi.org/10.1159/000503845DOI Listing
November 2019

BalanCI: Head-Referenced Cochlear Implant Stimulation Improves Balance in Children with Bilateral Cochleovestibular Loss.

Audiol Neurootol 2020 1;25(1-2):60-71. Epub 2019 Nov 1.

Department of Otolaryngology, Head and Neck Surgery, Hospital for Sick Children, Toronto, Ontario, Canada,

Introduction: To determine the impact of a head-referenced cochlear implant (CI) stimulation system, BalanCI, on balance and postural control in children with bilateral cochleovestibular loss (BCVL) who use bilateral CI.

Methods: Prospective, blinded case-control study. Balance and postural control testing occurred in two settings: (1) quiet clinical setting and (2) immersive realistic virtual environment (Challenging Environment Assessment Laboratory [CEAL], Toronto Rehabilitation Institute). Read More

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http://dx.doi.org/10.1159/000503135DOI Listing
November 2019

Cochlear Dead Regions in Sporadic Unilateral Vestibular Schwannomas Using the Threshold-Equalizing Noise Test.

Audiol Neurootol 2019 30;24(6):271-278. Epub 2019 Oct 30.

Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea,

Background: Vestibular schwannoma (VS) is a benign intracranial neoplasm originating in the Schwann cells of the vestibular nerve. Despite its origin, the most common symptom is sensorineural hearing loss which is presented in more than 90% of patients. The underlying pathophysiology of this hearing loss has not been fully understood. Read More

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http://dx.doi.org/10.1159/000503164DOI Listing
October 2019

Is Early Cochlear Implant Device Activation Safe for All on-the-Ear and off-the-Ear Sound Processors?

Audiol Neurootol 2019 30;24(6):279-284. Epub 2019 Oct 30.

Department of Otorhinolarygology, Hacettepe University, Ankara, Turkey.

Background: Cochlear implantation (CI) is an effective treatment option for patients with severe-to-profound hearing loss. When CI first started, it was recommended to wait until at least 4 weeks after the CI surgery for the initial activation because of possible complications. Advances in the surgical techniques and experiences in fitting have made initial activation possible within 24 h. Read More

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http://dx.doi.org/10.1159/000503378DOI Listing
October 2019

Restoring the High-Frequency Dynamic Visual Acuity with a Vestibular Implant Prototype in Humans.

Audiol Neurootol 2020 29;25(1-2):91-95. Epub 2019 Oct 29.

Division of Balance Disorders, Department of Otorhinolaryngology and Head and Neck Surgery, Maastricht University Medical Center, School for Mental Health and Neuroscience, Maastricht, The Netherlands.

Introduction: The vestibular implant could become a clinically useful device in the near future. This study investigated the feasibility of restoring the high-frequency dynamic visual acuity (DVA) with a vestibular implant, using the functional Head Impulse Test (fHIT).

Methods: A 72-year-old female, with bilateral vestibulopathy and fitted with a modified cochlear implant incorporating three vestibular electrodes (MED-EL, Innsbruck, Austria), was available for this study. Read More

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http://dx.doi.org/10.1159/000503677DOI Listing
October 2019
1.852 Impact Factor

Are There Cochlear Dead Regions Involved in Hearing Loss after Cisplatin Ototoxicity?

Audiol Neurootol 2019 29;24(5):253-257. Epub 2019 Oct 29.

Department of Audiology, AC Camargo Cancer Center, São Paulo, Brazil.

Background: The most common complaint of patients affected by chemotherapy-induced hearing loss is difficulty understanding speech in noisy environments despite the use of hearing aids. Cochlear dead regions, those areas with damaged or absent inner hair cells and dendrites, may account for this type of hearing loss. However, it is unknown whether this condition is associated with cisplatin agents. Read More

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http://dx.doi.org/10.1159/000502250DOI Listing

A Novel Pathogenic Variant in the CABP2 Gene Causes Severe Nonsyndromic Hearing Loss in a Consanguineous Iranian Family.

Audiol Neurootol 2019 29;24(5):258-263. Epub 2019 Oct 29.

Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran,

Background And Objectives: Hereditary hearing loss (HL) can originate from mutations in one of many genes involved in the complex process of hearing. CABP2 mutations have been reported to cause moderate HL. Here, we report the whole exome sequencing (WES) of a proband presenting with prelingual, severe HL in an Iranian family. Read More

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http://dx.doi.org/10.1159/000502251DOI Listing
May 2020
1 Read

Cochlear Place of Stimulation Is One Determinant of Cochlear Implant Sound Quality.

Audiol Neurootol 2019 29;24(5):264-269. Epub 2019 Oct 29.

Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, Tennessee, USA.

Objective: Our aim was to determine the effect of acute changes in cochlear place of stimulation on cochlear implant (CI) sound quality.

Design: In Experiment 1, 5 single-sided deaf (SSD) listeners fitted with a long (28-mm) electrode array were tested. Basal shifts in place of stimulation were implemented by turning off the most apical electrodes and reassigning the filters to more basal electrodes. Read More

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http://dx.doi.org/10.1159/000503217DOI Listing

Influence of Cochlear Implantation on Postural Control and Risk of Falls.

Audiol Neurootol 2019 22;24(5):245-252. Epub 2019 Oct 22.

Department of Otorhinolaryngology, Head and Neck Surgery, Ludwig-Maximilians-Universität München, Munich, Germany.

Background: Cochlear implantation is an important method of hearing rehabilitation. Earlier studies have shown the influence of implantation on the vestibular system. However, until now, the effect of hearing rehabilitation with cochlear implants (CI) on postural control and body stability has not been sufficiently studied. Read More

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http://dx.doi.org/10.1159/000503165DOI Listing
May 2020
1 Read

Sustained-Release Triamcinolone Acetonide Hydrogels Reduce Hearing Threshold Shifts in a Model for Cochlear Implantation with Hearing Preservation.

Audiol Neurootol 2019 1;24(5):237-244. Epub 2019 Oct 1.

Department of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria.

Introduction: In recent years, the preservation of residual hearing has become a major factor in patients undergoing cochlear implantation (CI). In studies attempting to pharmaceutically improve hearing preservation rates, glucocorticoids (GCs) applied perioperatively in many institutions have emerged as a promising treatment regimen. Although dexamethasone is most commonly used and has been applied successfully by various research groups, recently pharmacological properties have been reported to be relatively unsuitable for topical delivery to the inner ear. Read More

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http://dx.doi.org/10.1159/000501331DOI Listing

Wide-Band Tympanometry Results during an Acute Episode of Ménière's Disease.

Audiol Neurootol 2019 25;24(5):231-236. Epub 2019 Sep 25.

Department of Otorhinolaryngology, Dokuz Eylul University Medical School, Izmir, Turkey.

Background: Wide-band tympanometry (WBT) was introduced as a beneficial diagnostic test for Ménière's disease (MD) almost 15 years ago. However, an acute episode of MD has not been evaluated by using WBT yet.

Objective: To investigate WBT findings in patients with MD during acute attacks. Read More

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http://dx.doi.org/10.1159/000502768DOI Listing

Concepts and Physiological Aspects of the Otolith Organ in Relation to Electrical Stimulation.

Authors:
Ian S Curthoys

Audiol Neurootol 2020 25;25(1-2):25-34. Epub 2019 Sep 25.

Vestibular Research Laboratory, School of Psychology, University of Sydney, Sydney, New South Wales, Australia,

Background: This paper discusses some of the concepts and major physiological issues in developing a means of electrically stimulating the otolithic system, with the final goal being the electrical stimulation of the otoliths in human patients. It contrasts the challenges of electrical stimulation of the otolith organs as compared to stimulation of the semicircular canals. Electrical stimulation may consist of trains of short-duration pulses (e. Read More

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http://dx.doi.org/10.1159/000502712DOI Listing
September 2019

High Risk of Sudden Sensorineural Hearing Loss in Several Autoimmune Diseases according to a Population-Based National Sample Cohort Study.

Audiol Neurootol 2019 24;24(5):224-230. Epub 2019 Sep 24.

Department of Otorhinolaryngology, National Health Insurance Service Ilsan Hospital, Goyang, Republic of Korea,

Objective: We investigated the risk of sudden sensorineural hearing loss (SSNHL) in patients with autoimmune diseases compared with a control group in a population-based study using a National Health Insurance Service National Sample Cohort data from Korea.

Methods: We enrolled autoimmune-disease patients who were ≥20 years of age in 2006 into the autoimmune-disease group, and selected a control group with similar demographic characteristics. We tracked the 2 groups from 2006 to 2015 and compared the proportions of patients who developed SSNHL. Read More

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http://dx.doi.org/10.1159/000502677DOI Listing
May 2020
4 Reads

Electrical Vestibular Stimulation in Humans: A Narrative Review.

Audiol Neurootol 2020 18;25(1-2):6-24. Epub 2019 Sep 18.

European Institute for Otorhinolaryngology, GZA Hospitals Antwerp, Wilrijk, Belgium.

Background: In patients with bilateral vestibulopathy, the regular treatment options, such as medication, surgery, and/or vestibular rehabilitation, do not always suffice. Therefore, the focus in this field of vestibular research shifted to electrical vestibular stimulation (EVS) and the development of a system capable of artificially restoring the vestibular function. Key Message: Currently, three approaches are being investigated: vestibular co-stimulation with a cochlear implant (CI), EVS with a vestibular implant (VI), and galvanic vestibular stimulation (GVS). Read More

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http://dx.doi.org/10.1159/000502407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050666PMC
September 2019
1 Read

Rat Model of Ménière's Attack: Intratympanic Injection of Potassium Chloride Produces Direction-Changing Spontaneous Nystagmus and Hearing Fluctuations.

Audiol Neurootol 2019 13;24(5):217-223. Epub 2019 Sep 13.

Department of Neuroscience and Cell Biology, Osaka University Graduate School of Medicine, Suita, Japan.

The major symptoms of Ménière's disease are episodic vertigo, fluctuating hearing loss, and tinnitus. Direction-changing spontaneous nystagmus is a characteristic vestibular finding in Ménière's disease. In the acute stage, spontaneous nystagmus beating to the affected side (irritative nystagmus) is often observed, while paralytic nystagmus beating to the healthy side is found in the chronic stage. Read More

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http://dx.doi.org/10.1159/000502275DOI Listing