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    3379 results match your criteria Atypical Mycobacterial Diseases

    1 OF 68

    Multifocal ulceronecrotic skin lesions-A stigmatizing case.
    IDCases 2017 11;10:61-62. Epub 2017 Sep 11.
    Division of Microbiology and Infectious Diseases, Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, Canada.
    Mycobacterium chelonae is a rapidly growing nontuberculous mycobacteria, ubiquitous in the environment and mostly involved in skin, soft tissue and bone infections. An atypical, severe and multifocal dermatological manifestation of Mycobacterium chelonae infection in an immunocompetent patient is described here. The lesions completely resolved using a multidisciplinary approach. Read More

    Implantable cardiac defibrillator infections: the emerging importance of Mycobacterium fortuitum.
    BMJ Case Rep 2017 Sep 19;2017. Epub 2017 Sep 19.
    Department t of Internal Medicine Critical Care, TTUHSC, Lubbock, Texas, USA.
    Infection is a clinically relevant complication associated with intracardiac devices. Atypical mycobacteria, particularly Mycobacterium fortuitum, have been increasingly implicated in cardiovascular implantable electronic device (CIED) infections. We present a case of M. Read More

    Sporotrichoid-Like Spread of Cutaneous Mycobacterium chelonae in an Immunocompromised Patient.
    Case Rep Dermatol Med 2017 23;2017:8219841. Epub 2017 Aug 23.
    Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA, USA.
    Mycobacterium chelonae is a rapidly growing mycobacterium found in water and soil that can cause local cutaneous infections in immunocompetent hosts but more frequently affects immunocompromised patients. Typically, patients will present with painful subcutaneous nodules of the joints or soft tissues from traumatic inoculation. However, exhibiting a sporotrichoid-like pattern of these nodules is uncommon. Read More

    Tuberculous otitis media: a resurgence?
    J Laryngol Otol 2017 Sep 20;131(9):785-792. Epub 2017 Jul 20.
    Madras ENT Research Foundation,Chennai,Tamil Nadu,India.
    Objective: Tuberculosis is a global health problem that is especially prevalent in developing countries such as India. Recently, atypical presentation has become more common and a high index of suspicion is essential. This study analysed the various presenting symptoms and signs of tuberculous otitis media and the role of diagnostic tests, with the aim of formulating criteria for the diagnosis. Read More

    [[Video-assisted pulmonary resection application for pulmonary tuberculosis].]
    Klin Khir 2016 Aug(8):40-43
    Results of application of video-assisted (video-assisted thoracic surgery VATS) pulmonary resection for pulmonary tuberculosis in 63 patients in 2008 - 2016 yrs were analyzed. Typical lobectomy was done in 28 (44.4%) patients, pulmonectomy - in 1 (1. Read More

    Nontuberculous mycobacterial disease in childhood - update on diagnostic approaches and treatment.
    J Infect 2017 Jun;74 Suppl 1:S136-S142
    Department of Paediatrics, The University of Melbourne, Parkville, Australia; Academic Unit of Clinical & Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK; NIHR Respiratory Biomedical Research Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Global Health Research Institute, University of Southampton, Southampton, UK; Department of Paediatric Infectious Diseases & Immunology, Evelina London Children's Hospital, Guy's and St. Thomas' NHS Foundation Trust, London, UK. Electronic address:
    Recent studies suggest that the incidence of nontuberculous mycobacterial infections in children may be increasing. Nontuberculous mycobacterial lymphadenitis, skin and soft tissue infection, and pulmonary disease each present unique challenges in relation to diagnosis and treatment. In this update, we critically review the recent literature on the epidemiology, clinical features, diagnostic approaches and treatment of nontuberculous mycobacterial disease in children. Read More

    The impact of glycemic status on radiological manifestations of pulmonary tuberculosis in diabetic patients.
    PLoS One 2017 19;12(6):e0179750. Epub 2017 Jun 19.
    Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
    Setting: Diabetes mellitus (DM) may increase risk of pulmonary tuberculosis (PTB) and influence its radiological manifestations.

    Objective: To evaluate the impact of glycemic status on radiological findings of PTB in diabetic patients.

    Methods: Between January 2010 and December 2015, chest radiographs (CXRs) in consecutive 214 DM patients with culture-proved PTB and 123 available thoracic computed tomography (CT) scans were enrolled. Read More

    Original Mycobacterial Sin, a consequence of highly homologous antigens?
    Vet Microbiol 2017 May 27;203:286-293. Epub 2017 Mar 27.
    Division of Immunology, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL, Utrecht, The Netherlands; Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort, 0110, South Africa.
    The role of antigens shared between Mycobacteria in in-vivo cross-reactive immune responses in host animals, have been reported to be responsible for reduced BCG vaccination efficacy as well reduced specificity of routine immunological diagnostic tests. This presents with significant disease control challenges in humans and animals. The present review highlights the results of previous studies on the effect of pre-sensitization to environmental mycobacteria on either pathogenic mycobacteria and/or M. Read More

    Genetic diversity of Mycobacterium tuberculosis isolates from Tochigi prefecture, a local region of Japan.
    BMC Infect Dis 2017 May 25;17(1):365. Epub 2017 May 25.
    Tochigi Prefectural Institute of Public Health and Environmental Science, Utsunomiya, Tochigi, Japan.
    Background: Foreign-born patients with tuberculosis (TB) may introduce globally disseminated isolates of Mycobacterium tuberculosis into large cities in Japan. The risk of dissemination of these isolates into local regions, however, has not been determined. This study analyzed the molecular epidemiology of M. Read More

    Treatment of Non-Tuberculous Mycobacterial Lung Disease.
    Curr Treat Options Infect Dis 2016 Dec 11;8(4):275-296. Epub 2016 Oct 11.
    Department of Medicine and Academic Affairs, National Jewish Health, Denver, Colorado.
    Treatment of non-tuberculous mycobacterial lung disease (NTM-LD) is challenging for several reasons including the relative resistance of NTM to currently available drugs and the difficulty in tolerating prolonged treatment with multiple drugs. Yet-to-be-done, large, multicenter, prospective randomized studies to establish the best regimens will also be arduous because multiple NTM species are known to cause human lung disease, differences in virulence and response to treatment between different species and strains within a species will make randomization more difficult, the need to distinguish relapse from a new infection, and the difficulty in adhering to the prescribed treatment due to intolerance, toxicity, and/or drug-drug interactions, often necessitating modification of therapeutic regimens. Furthermore, the out-of-state resident status of many patients seen at the relatively few centers that care for large number of NTM-LD patients pose logistical issues in monitoring response to treatment. Read More

    Development of a potent invigorator of immune responses endowed with both preventive and therapeutic properties.
    Biologics 2017 2;11:55-63. Epub 2017 May 2.
    Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.
    This article reviews briefly the making of an immunoprophylactic-cum-immunotherapeutic vaccine against leprosy. The vaccine is based on cultivable, heat-killed atypical mycobacteria, whose gene sequence is now known. It has been named Mycobacterium indicus pranii. Read More

    Modulation of Mycobacterium tuberculosis-specific humoral immune responses is associated with Strongyloides stercoralis co-infection.
    PLoS Negl Trop Dis 2017 May 1;11(5):e0005569. Epub 2017 May 1.
    National Institutes of Health-NIRT-International Center for Excellence in Research, Chennai, India.
    Background / Objectives: Helminth infections are known to influence T cell responses in latent tuberculosis (LTBI). Whether helminth infections also modulate B cell responses in helminth-tuberculosis co-infection is not known.

    Methods: We assessed Mycobacterium tuberculosis (Mtb)-antigen specific IgM and IgG levels, circulating levels of the B cell growth factors, BAFF and APRIL and the absolute numbers of the various B cell subsets in individuals with LTBI, LTBI with coincident Strongyloides stercoralis (Ss) infection (LTBI/Ss) and in those with Ss infection alone (Ss). Read More

    An Amidase_3 domain-containing N-acetylmuramyl-L-alanine amidase is required for mycobacterial cell division.
    Sci Rep 2017 Apr 25;7(1):1140. Epub 2017 Apr 25.
    DST/NRF Centre of Excellence for Biomedical TB Research, Faculty of Health Sciences, University of the Witwatersrand, National Health Laboratory Service, Johannesburg, 2001, South Africa.
    Mycobacteria possess a multi-layered cell wall that requires extensive remodelling during cell division. We investigated the role of an amidase_3 domain-containing N-acetylmuramyl-L-alanine amidase, a peptidoglycan remodelling enzyme implicated in cell division. We demonstrated that deletion of MSMEG_6281 (Ami1) in Mycobacterium smegmatis resulted in the formation of cellular chains, illustrative of cells that were unable to complete division. Read More

    Tuberculosis-associated hemophagocytic lymphohistiocytosis with initial presentation of fever of unknown origin in a general hospital: An analysis of 8 clinical cases.
    Medicine (Baltimore) 2017 Apr;96(16):e6575
    Department of General Internal Medicine, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Science (CAMS), and Peking Union Medical College (PUMC), Beijing, China.
    The study aimed to investigate the clinical features and prognoses of patients with tuberculosis (TB) who had secondary hemophagocytic lymphohistiocytosis (HLH).Patients first presenting with fever of unknown origin, who were ultimately diagnosed with TB-associated secondary HLH, were assessed retrospectively. We summarized and analyzed clinical manifestations, laboratory examinations, diagnoses, treatments, and prognoses of patients using clinical data, outpatient follow-up, and telephone follow-up in combination with literature review. Read More

    Nontuberculous mycobacterial infection of the musculoskeletal system in immunocompetent hosts.
    Indian J Orthop 2017 Mar-Apr;51(2):205-212
    Department of Pathology, Hinduja Hospital and Medical Research Center, Mumbai, Maharashtra, India.
    Background: Nontuberculous mycobacteria (NTM) were considered saprophytic organisms for many years but now are recognized as human pathogens. Although humans are routinely exposed to NTM, the rate of clinical infection is low. Such infections usually occur in the elderly and in patients who are immunocompromised. Read More

    Atypical spinal tuberculosis involved noncontiguous multiple segments: Case series report with literature review.
    Medicine (Baltimore) 2017 Apr;96(14):e6559
    aDepartment of Orthopedics, West China Hospital, Sichuan University bDepartment of Orthopedics, Sichuan Orthopaedic Hospital, Chengdu, China.
    In its typical form, spinal tuberculosis (TB) presents as destroyed contiguous vertebral bodies with involvement of intervertebral discs and paravertebral or psoas abscesses. Atypical forms are uncommonly reported. Here, we describe 8 patients with noncontiguous multisegmental spinal TB with no intervertebral disc involvement. Read More

    Biofilm colonization in chronic treatment refractory infections presenting with discharging sinuses: A study in a tertiary care hospital of Eastern India.
    J Lab Physicians 2017 Apr-Jun;9(2):125-131
    Department of Microbiology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India.
    Introduction: Treatment refractory chronic recurrent infections mean those chronic infections which recur by same causal agents with similar drug responsiveness after apparent relief following full course of recommended antimicrobial management.

    Materials And Methods: Fifty different samples were collected from patients with chronic surgical site infections, laparoscopic port site infections, anal fistula, mesh hernioplasty, chronic dacryocystitis, chronic osteomyelitis, and chronic burn wounds. Samples were processed for culture, identification, antibiotic sensitivity testing using standard microbiological techniques. Read More

    Atypical Mycobacterial Infections of the Upper Extremity: Becoming More Atypical?
    Hand (N Y) 2017 Mar 7;12(2):188-192. Epub 2016 Jul 7.
    University of Texas Medical Branch, Galveston, USA.
    Background: Atypical mycobacterial infections are uncommon and characterized by a chronic, indolent course before diagnosis. Historically, these infections are associated with marine-related injury and/or immune dysfunction. Our institution has successfully diagnosed and treated an increasing number of these infections. Read More

    Atypical Hand Infections.
    Orthop Clin North Am 2017 Apr 1;48(2):229-240. Epub 2017 Feb 1.
    Department of Hand Surgery, The Hand Center of San Antonio, 21 Spurs Lane, #310, San Antonio, TX 78240, USA.
    Atypical infections of the hand are caused by organisms such as Mycobacterium, fungi, and viruses, and often do not respond to conventional management. They exist within a wide spectrum of presentations, ranging from cutaneous lesions to deep infections such as tenosynovitis and osteomyelitis. Having a high clinical suspicion for atypical hand infections is vital because diagnosis often requires special tests and/or cultures. Read More

    Port-site infections by nontuberculous mycobacterium: A retrospective clinico-microbiological study.
    Int J Mycobacteriol 2017 Jan-Mar;6(1):34-37
    Department of Microbiology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India.
    Background: Port-site infection (PSI) is a prevailing, chronic, nagging, treatment refractory complication of laparoscopic surgery (LS). It neutralizes the advantages of minimally invasive surgery and increases morbidity, treatment cost of patient, leading to loss of confidence on operating surgeon. PSIs are preventable with appropriate preoperative, intraoperative, and postoperative measures. Read More

    Pseudotumoral form of soft tissue tuberculosis of the hand: six cases.
    Pan Afr Med J 2016 21;25:178. Epub 2016 Nov 21.
    Orthopedic surgery and Trauma Department, Maamouri Hospital, Nabeul, Tunisia.
    Musculoskeletal involvement is not uncommon in extra-pulmonary tuberculosis, but the localization in the soft tissue of the hand is very rare. Diagnosis is much more difficult because of the atypical location and non-specific symptoms. We report 6 cases of pseudotumoral form of soft tissue tuberculosis of the hand treated in our department during the past 12 years. Read More

    Central Nervous System Tuberculosis: An Imaging Perspective.
    Can Assoc Radiol J 2017 May 7;68(2):161-170. Epub 2017 Mar 7.
    Department of Radiodiagnosis, PGIMER, Dr. RML Hospital, New Delhi-110001, India.
    The increasing prevalence of tuberculosis in both immunocompetent and immunocompromised individuals in recent years makes the disease a topic of universal concern. It has insidious onset and can affect virtually any organ system in the body, including the central nervous system (CNS). CNS tuberculosis (TB) is becoming more and more complex and atypical with onset of multidrug-resistant TB. Read More

    Miliary Tuberculosis.
    Microbiol Spectr 2017 Mar;5(2)
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Sri Venkateswara Institute of Medical Sciences, Tirupati 517 507, India.
    Miliary tuberculosis (TB) results from a massive lymphohematogenous dissemination of Mycobacterium tuberculosis bacilli and is characterized by tiny tubercles evident on gross pathology resembling millet seeds in size and appearance. The global HIV/AIDS pandemic and widespread use of immunosuppressive drugs and biologicals have altered the epidemiology of miliary TB. Considered to be predominantly a disease of infants and children in the pre-antibiotic era, miliary TB is increasingly being encountered in adults as well. Read More

    Expect the Unexpected: Mycobacterial Infection in Post Total Knee Arthroplasty Patients.
    J Clin Diagn Res 2017 Jan 1;11(1):RD01-RD02. Epub 2017 Jan 1.
    Associate Professor, Department of Orthopaedics, Seth G.S. Medical College and K.E.M. Hospital , Mumbai, Maharashtra, India .
    Orthopaedic Surgeons rarely encounter mycobacterial infections in Post Total Knee Arthroplasty (TKA) patients. We present series of two cases to create awareness among clinicians to expect the unexpected. Tuberculosis typical/ atypical is a hidden culprit in catch clinical situations when chronic infection is Suspected, but the lab investigations are negative in persistently symptomatic patients. Read More

    Screening in Maternity to Ascertain Tuberculosis Status (SMATS) study.
    BMC Infect Dis 2017 Mar 6;17(1):191. Epub 2017 Mar 6.
    URC Swaziland, Mbabane, Swaziland.
    Background: Diagnosis of tuberculosis is difficult among pregnant women because the signs and symptoms of the disease, such as fatigue, shortness of breath, sweating, cough, and mild fever are similar to some manifestations of pregnancy. It is particularly challenging among HIV-infected women as symptoms are often masked or atypical. Currently, WHO recommends a standard four-symptom screening tool for pregnant and lactating women. Read More

    Mycobacterial Arthritis and Synovitis in Painted Reed Frogs (Hyperolius marmoratus).
    J Comp Pathol 2017 Feb - Apr;156(2-3):275-280. Epub 2017 Feb 21.
    National Zoological Gardens of South Africa, Pretoria, South Africa.
    Several species of atypical mycobacteria have been isolated from wild and captive amphibians. In captive anurans, cutaneous and visceral mycobacteriosis are common and can result in significant mortality, particularly when animals are immunocompromised. Mycobacterial arthritis and synovitis are reported rarely in amphibians. Read More

    Molecular identification and distribution of non-tuberculous mycobacteria isolated from clinical specimens by PCR-sequencing method in West of Iran.
    Clin Respir J 2017 Feb 22. Epub 2017 Feb 22.
    Department of Microbiology, Faculty of Medicine, Kermanshah University of Medical Sciences, Shirudi Shahid Boulevard, Daneshgah Street, Kermanshah, 67148-69914, Iran.
    Background And Aims: Infections by non-tuberculous mycobacteria (NTM) has rapidly increased in recent years, due to high infection rates related to the populations at risk like immunocompromised individuals, patients predisposed by prior pulmonary. The aim of this study was to investigate the presence of NTM in clinical samples and genetic diversity using 16S rRNA and rpoB sequence analysis.

    Methods: A cross-sectional study was conducted on 45 diverse isolates collected from sputum in 2 years 2014-2015 using standard decontamination procedure. Read More

    When the Great Masquerader Reveals Itself-Tuberculosis.
    Pediatr Ann 2017 Feb;46(2):e51-e55
    Pneumonia is a clinical diagnosis often treated empirically and successfully on an outpatient basis. When a patient fails to improve, the clinician is left to revisit the differential of pathogens and reconsider the host. Admission, imaging, and invasive and noninvasive testing are part of the toolkit for the severe or atypical case of pneumonia. Read More

    Coexistent Sarcoidosis and Tuberculosis: A Case Report.
    Respiration 2017 9;93(4):296-300. Epub 2017 Feb 9.
    Department of Medical and Surgical Sciences, Institute of Respiratory Diseases, Azienda Ospedaliero Universitaria Foggia, Foggia, Italy.
    Necrotizing granulomatous diseases of the lungs are usually dependent on a narrow range of differential diagnoses. Tuberculosis (TB) is responsible for the largest number of cases, while necrotizing sarcoidosis is generally considered a rare and easily distinguishable disease substantially based on histological features. However, this entity has become a viable diagnosis in the absence of mycobacteria isolation or when a remarkable clinical improvement cannot be achieved with the combination of anti-TB drugs at full dosage. Read More

    Investigation of a Medieval Pilgrim Burial Excavated from the Leprosarium of St Mary Magdalen Winchester, UK.
    PLoS Negl Trop Dis 2017 Jan 26;11(1):e0005186. Epub 2017 Jan 26.
    Department of Microbial and Cellular Sciences, Faculty of Health and Medical Sciences, AX Building, University of Surrey, Guildford, Surrey, United Kingdom.
    We have examined the remains of a Pilgrim burial from St Mary Magdalen, Winchester. The individual was a young adult male, aged around 18-25 years at the time of death. Radiocarbon dating showed the remains dated to the late 11th-early 12th centuries, a time when pilgrimages were at their height in Europe. Read More

    Prospective etiological investigation of community-acquired pulmonary infections in hospitalized people living with HIV.
    Medicine (Baltimore) 2017 Jan;96(4):e5778
    aScientific Division, Instituto de Infectologia Emílio Ribas, São Paulo, SP, Brazil bDepartment of Medicine Solna, Infectious Diseases Unit, Karolinska Institutet cDepartment of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden dEmilio Ribas Institute of Infectious Diseases eDepartment of Infectious Diseases, University of São Paulo Medical School, São Paulo, SP, Brazil.
    The study of the etiological agents of community-acquired pulmonary infections is important to guide empirical therapy, requires constant updating, and has a substantial impact on the prognosis of patients. The objective of this study is to determine prospectively the etiology of community-acquired pulmonary infections in hospitalized adults living with HIV. Patients were submitted to an extended microbiological investigation that included molecular methods. Read More

    Atypical Mycobacterial Infection after Abdominoplasty Overseas: A Case Report and Literature Review.
    Case Rep Infect Dis 2016 27;2016:3642567. Epub 2016 Dec 27.
    Department of Infectious Diseases, Yale New Haven Health System, Bridgeport Hospital, Bridgeport, CT 06610, USA.
    Increasing number of medical tourists travel internationally for cosmetic procedures. Lipotourism is a form of medical tourism becoming popular among patients of developed countries due to the cost efficiency of cosmetic procedures when performed in developing nations. There is a paucity of data on quality, safety, and risks involved with these surgeries. Read More

    Bacteria endocarditis consolidation with vertebra bone tuberculosis: a case report.
    BMC Infect Dis 2017 Jan 6;17(1):38. Epub 2017 Jan 6.
    Department of Geriatrics, Xijing Hospital, Fourth Military Medical University, Changle West Road #127, Xi'an, Shaanxi Province, 710032, People's Republic of China.
    Background: The clinical features of bacteria endocarditis became atypical when consolidated with other conditions such as tuberculosis (TB). Especially, the symptoms of bacteria endocarditis (BE) which were hidden behind the TB fever often lead to misdiagnosis and missed diagnosis.

    Case Presentation: A 56-year-old male with thoracic vertebra bone TB history presented with low-grade fever, shortness of breath and cardiac souffle. Read More

    A Case of Surgical Site Infection Caused by Mycobacterium fortuitum, following Herniorrhaphy.
    J Clin Diagn Res 2016 Nov 1;10(11):DD01-DD02. Epub 2016 Nov 1.
    Associate Professor, Department of General Surgery, Indira Gandhi Medical College and Research Institute , Puducherry, India .
    Rapidly Growing Mycobacteria (RGM) are opportunistic pathogens found in the environment. Mycobacterium fortuitum, M. chelonae and M. Read More

    Mycobacterium haemophilum: A report of cutaneous Infection in a Patient with end-stage renal disease.
    Int J Mycobacteriol 2016 Dec 9;5 Suppl 1:S236. Epub 2016 Nov 9.
    Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:
    Introduction: Mycobacterium haemophilum is a slow-growing nontuberculous mycobacterium (NTM) that can cause ulcerating cutaneous or subcutaneous nodular skin lesions in immunocompromised and immunocompetent patients. Acid-fast staining cannot distinguish NTM from M. tuberculosis; culturing at two temperatures with iron-supplemented media and polymerase chain reaction (PCR) are needed for optimal detection of M. Read More

    IL-12Rβ1 defect presenting with massive intraabdominal lymphadenopathy due to Mycobacterium intracellulare: A case report.
    Asian Pac J Allergy Immunol 2016 Dec 12. Epub 2016 Dec 12.
    Marmara University School of Medicine, Department of Pediatrics, Division of Pediatric Infectious Diseases, Istanbul, Turkey.
    Infections due to non-tuberculous mycobacteria species are problematic for immunodeficient individuals. Mendelian susceptibility to mycobacterial diseases (MSMD) defines a group of genetic defects affecting cellular interactions and the interferon (IFN)-γ pathway. Patients with MSMD may present with a disseminated infection resulting from the Bacillus Calmette-Guerin vaccine, Mycobacterium tuberculosis complex, environmental nontuberculous mycobacteria or Salmonella species. Read More

    Pulmonary Mycobacterium kansasii disease in immunocompetent host: Treatment outcomes with short-course chemotherapy.
    Indian J Med Microbiol 2016 Oct-Dec;34(4):516-519
    Department of Clinical Research, National Institute for Research in Tuberculosis, Chennai, Tamil Nadu, India.
    Mycobacterium kansasii, most virulent of all atypical mycobacteria, causes pulmonary disease identical to the disease caused by Mycobacterium tuberculosis. Early identification of the species and prompt initiation of treatment for M. kansasii is necessary to prevent morbidity and mortality due to this disease. Read More

    Clinical implications of Mycobacterium chimaera detection in thermoregulatory devices used for extracorporeal membrane oxygenation (ECMO), Germany, 2015 to 2016.
    Euro Surveill 2016 Nov;21(46)
    Institute of Medical Microbiology and Hygiene, Saarland University, Homburg/Saar, Germany.
    Mycobacterium chimaera, a non-tuberculous mycobacterium, was recently identified as causative agent of deep-seated infections in patients who had previously undergone open-chest cardiac surgery. Outbreak investigations suggested an aerosol-borne pathogen transmission originating from water contained in heater-cooler units (HCUs) used during cardiac surgery. Similar thermoregulatory devices are used for extracorporeal membrane oxygenation (ECMO) and M. Read More

    Novel Mutation of Interferon-γ Receptor 1 Gene Presenting as Early Life Mycobacterial Bronchial Disease.
    J Investig Med High Impact Case Rep 2016 Oct-Dec;4(4):2324709616675463. Epub 2016 Nov 8.
    Children's National Medical Center, Washington, DC, USA; George Washington University, Washington, DC, USA.
    Mendelian susceptibility to mycobacterial diseases (MSMD) are a spectrum of inherited disorders characterized by localized or disseminated infections caused by atypical mycobacteria. Interferon-γ receptor 1 (IFNGR1) deficiency was the first identified genetic disorder recognized as MSMD. Mutations in the genes encoding IFNGR1 can be recessive or dominant and cause complete or partial receptor deficiency. Read More

    Mycobacterium chelonae in a tectonic corneal graft.
    Oman J Ophthalmol 2016 Sep-Dec;9(3):177-178
    Sussex Eye Hospital, Brighton, East Sussex, BN2 5BF, UK.
    Atypical mycobacterial infections of the cornea can present with nonspecific inflammatory changes and graft rejection, with no obvious focus to culture and a subsequent delay to diagnosis. These pathogens are well documented in the literature following laser-assisted in situ keratomileusis but have rarely been described following corneal transplant surgery. We report a single case of Mycobacterium chelonae keratitis 1 year after tectonic keratoplasty. Read More

    Imaging in extrapulmonary tuberculosis.
    Int J Infect Dis 2017 Mar 10;56:237-247. Epub 2016 Nov 10.
    Department of Nuclear Medicine, of Nuclear Medicine, UCLH NHS Foundation Trust, 235 Euston Road, London NW1 2BU, UK. Electronic address:
    Tuberculosis (TB) remains a major global public health problem, with 1.5 million deaths annually worldwide. One in five cases of TB present as extrapulmonary TB (EPTB), posing major diagnostic and management challenges. Read More

    Abdominal tuberculosis: an old disease surprising young doctors.
    BMJ Case Rep 2016 Nov 2;2016. Epub 2016 Nov 2.
    Department of Surgery-Cirurgia B, Hospital Professor Doutor Fernando Fonseca EPE, Amadora, Portugal.
    Tuberculosis remains a worldwide public health concern. Atypical extrapulmonary presentations may delay the diagnosis and treatment. We present the case of an adult woman admitted to the emergency department with bowel obstruction. Read More

    Tuberculous Fasciitis in Polymyositis: A Rare Case of Extrapulmonary Tuberculosis.
    Intern Med 2016;55(21):3205-3209. Epub 2016 Nov 1.
    Department of Nephrology, Osaka Rosai Hospital, Japan.
    A 71-year-old woman with polymyositis presenting with left thigh pain and an intermittent fever was admitted to Osaka Rosai Hospital. We initially diagnosed that her pain and fever were caused by a soft tissue infection because her polymyositis was controlled. She did not respond to various antibiotic therapies. Read More

    [Pulmonary tuberculosis among hospitalized patients in Brazzaville: impact of late diagnosis of HIV infection on radiographic abnormalities].
    Pan Afr Med J 2016 20;24:259. Epub 2016 Jul 20.
    Faculté des Sciences de la Santé, Université Marien NGOUABI, Congo; Service de Pneumologie, CHU de Brazzaville-Congo.
    The aim was to describing the different radiographic features of pulmonary tuberculosis according to the degree of immunosuppression in HIV patients. We report a retrospective study of 80 untreated HIV-positive patients with pulmonary tuberculosis hospitalized in the Pneumo-Phthisiology Department in Brazzaville from January 2013 to January 2014. Our sample consisted of 44 women (55%) and 36 men (45%), the sex ratio was 0. Read More

    Hoarse voice: a rare presentation of tuberculosis lymphadenitis.
    BMJ Case Rep 2016 Oct 24;2016. Epub 2016 Oct 24.
    Imperial College Healthcare NHS Trust, London, UK.
    A man aged 37 years from Indian descent presented to an inner city London hospital with hoarseness of voice, fatigue, night sweats and a 2 kg weight loss. Laryngoscopy demonstrated a left vocal fold palsy. Extensive investigations were undertaken with disseminated malignancy being primarily investigated. Read More

    Leprae reaction resembling rheumatologic disease as presenting feature of leprosy.
    Int J Rheum Dis 2016 Oct 26;19(10):1035-1038. Epub 2016 Jul 26.
    Rheumatology Division, Hospital Selayang, Batu Caves, Malaysia.
    Leprosy is a chronic granulomatous infection caused by Mycobacterium leprae with predominant involvement of skin and nerves. We present a 70-year-old man with leprosy whose initial presentation resembled rheumatologic disease, due to leprae reaction. He presented with an 8-week history of worsening neuropathic pain in the right forearm, associated with necrotic skin lesions on his fingers that had ulcerated. Read More

    [Unclear liver lesions in a 19-year-old woman with acute myeloid leukemia].
    Internist (Berl) 2016 Nov;57(11):1121-1125
    Klinik für Onkologie und Hämatologie, Krankenhaus Barmherzige Brüder Regensburg, Prüfeningerstr. 86, 93049, Regensburg, Deutschland.
    A 19-year old woman with acute myeloid leukemia presented with newly observed liver lesions during ongoing consolidation therapy. Due to unexplained cholestasis during induction, biliary duct drainage was performed. Microbiologic and histologic examinations revealed the presence of atypical mycobacteria, namely Mycobacterium abscessus. Read More

    Mycobacterium avium Infection of Nasal Septum in a Diabetic Adult: A Case Report.
    Head Neck Pathol 2016 Dec 20;10(4):552-555. Epub 2016 Jun 20.
    Department of Pathology, Creighton University School of Medicine, Omaha, NE, USA.
    Mycobacterium avium complex (MAC) is primarily a pulmonary pathogen that affects individuals who are immune deficient or immunocompromised. In this report, we describe a very rare case of MAC infection clinically presenting as a nasal polyp in a patient with type 2 diabetes mellitus. This case illustrates an atypical anatomic location for MAC, the anterior nasal septum in nasal cavity, as well as often overlooked cause of immune compromise, diabetes mellitus. Read More

    Lobar Collapse Therapy Using Endobronchial Valves as a New Complementary Approach to Treat Cavities in Multidrug-Resistant Tuberculosis and Difficult-to-Treat Tuberculosis: A Case Series.
    Respiration 2016 12;92(5):316-328. Epub 2016 Oct 12.
    Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
    Background: The poor treatment outcomes of multidrug-resistant tuberculosis (TB) and the emergence of extensively drug-resistant TB and extremely and totally drug-resistant TB highlight the urgent need for new antituberculous drugs and other adjuvant treatment approaches.

    Objectives: We have treated cavitary tuberculosis by the application of endobronchial one-way valves (Zephyr®; Pulmonx Inc., Redwood City, Calif. Read More

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