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    3355 results match your criteria Atypical Mycobacterial Diseases

    1 OF 68

    Treatment of Non-Tuberculous Mycobacterial Lung Disease.
    Curr Treat Options Infect Dis 2016 Dec 11;8(4):275-296. Epub 2016 Oct 11.
    Department of Medicine and Academic Affairs, National Jewish Health, Denver, Colorado.
    Treatment of non-tuberculous mycobacterial lung disease (NTM-LD) is challenging for several reasons including the relative resistance of NTM to currently available drugs and the difficulty in tolerating prolonged treatment with multiple drugs. Yet-to-be-done, large, multicenter, prospective randomized studies to establish the best regimens will also be arduous because multiple NTM species are known to cause human lung disease, differences in virulence and response to treatment between different species and strains within a species will make randomization more difficult, the need to distinguish relapse from a new infection, and the difficulty in adhering to the prescribed treatment due to intolerance, toxicity, and/or drug-drug interactions, often necessitating modification of therapeutic regimens. Furthermore, the out-of-state resident status of many patients seen at the relatively few centers that care for large number of NTM-LD patients pose logistical issues in monitoring response to treatment. Read More

    Development of a potent invigorator of immune responses endowed with both preventive and therapeutic properties.
    Biologics 2017 2;11:55-63. Epub 2017 May 2.
    Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.
    This article reviews briefly the making of an immunoprophylactic-cum-immunotherapeutic vaccine against leprosy. The vaccine is based on cultivable, heat-killed atypical mycobacteria, whose gene sequence is now known. It has been named Mycobacterium indicus pranii. Read More

    Modulation of Mycobacterium tuberculosis-specific humoral immune responses is associated with Strongyloides stercoralis co-infection.
    PLoS Negl Trop Dis 2017 May 1;11(5):e0005569. Epub 2017 May 1.
    National Institutes of Health-NIRT-International Center for Excellence in Research, Chennai, India.
    Background / Objectives: Helminth infections are known to influence T cell responses in latent tuberculosis (LTBI). Whether helminth infections also modulate B cell responses in helminth-tuberculosis co-infection is not known.

    Methods: We assessed Mycobacterium tuberculosis (Mtb)-antigen specific IgM and IgG levels, circulating levels of the B cell growth factors, BAFF and APRIL and the absolute numbers of the various B cell subsets in individuals with LTBI, LTBI with coincident Strongyloides stercoralis (Ss) infection (LTBI/Ss) and in those with Ss infection alone (Ss). Read More

    An Amidase_3 domain-containing N-acetylmuramyl-L-alanine amidase is required for mycobacterial cell division.
    Sci Rep 2017 Apr 25;7(1):1140. Epub 2017 Apr 25.
    DST/NRF Centre of Excellence for Biomedical TB Research, Faculty of Health Sciences, University of the Witwatersrand, National Health Laboratory Service, Johannesburg, 2001, South Africa.
    Mycobacteria possess a multi-layered cell wall that requires extensive remodelling during cell division. We investigated the role of an amidase_3 domain-containing N-acetylmuramyl-L-alanine amidase, a peptidoglycan remodelling enzyme implicated in cell division. We demonstrated that deletion of MSMEG_6281 (Ami1) in Mycobacterium smegmatis resulted in the formation of cellular chains, illustrative of cells that were unable to complete division. Read More

    Tuberculosis-associated hemophagocytic lymphohistiocytosis with initial presentation of fever of unknown origin in a general hospital: An analysis of 8 clinical cases.
    Medicine (Baltimore) 2017 Apr;96(16):e6575
    Department of General Internal Medicine, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Science (CAMS), and Peking Union Medical College (PUMC), Beijing, China.
    The study aimed to investigate the clinical features and prognoses of patients with tuberculosis (TB) who had secondary hemophagocytic lymphohistiocytosis (HLH).Patients first presenting with fever of unknown origin, who were ultimately diagnosed with TB-associated secondary HLH, were assessed retrospectively. We summarized and analyzed clinical manifestations, laboratory examinations, diagnoses, treatments, and prognoses of patients using clinical data, outpatient follow-up, and telephone follow-up in combination with literature review. Read More

    Nontuberculous mycobacterial infection of the musculoskeletal system in immunocompetent hosts.
    Indian J Orthop 2017 Mar-Apr;51(2):205-212
    Department of Pathology, Hinduja Hospital and Medical Research Center, Mumbai, Maharashtra, India.
    Background: Nontuberculous mycobacteria (NTM) were considered saprophytic organisms for many years but now are recognized as human pathogens. Although humans are routinely exposed to NTM, the rate of clinical infection is low. Such infections usually occur in the elderly and in patients who are immunocompromised. Read More

    Atypical spinal tuberculosis involved noncontiguous multiple segments: Case series report with literature review.
    Medicine (Baltimore) 2017 Apr;96(14):e6559
    aDepartment of Orthopedics, West China Hospital, Sichuan University bDepartment of Orthopedics, Sichuan Orthopaedic Hospital, Chengdu, China.
    In its typical form, spinal tuberculosis (TB) presents as destroyed contiguous vertebral bodies with involvement of intervertebral discs and paravertebral or psoas abscesses. Atypical forms are uncommonly reported. Here, we describe 8 patients with noncontiguous multisegmental spinal TB with no intervertebral disc involvement. Read More

    Biofilm colonization in chronic treatment refractory infections presenting with discharging sinuses: A study in a tertiary care hospital of Eastern India.
    J Lab Physicians 2017 Apr-Jun;9(2):125-131
    Department of Microbiology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India.
    Introduction: Treatment refractory chronic recurrent infections mean those chronic infections which recur by same causal agents with similar drug responsiveness after apparent relief following full course of recommended antimicrobial management.

    Materials And Methods: Fifty different samples were collected from patients with chronic surgical site infections, laparoscopic port site infections, anal fistula, mesh hernioplasty, chronic dacryocystitis, chronic osteomyelitis, and chronic burn wounds. Samples were processed for culture, identification, antibiotic sensitivity testing using standard microbiological techniques. Read More

    Atypical Mycobacterial Infections of the Upper Extremity: Becoming More Atypical?
    Hand (N Y) 2017 Mar 7;12(2):188-192. Epub 2016 Jul 7.
    University of Texas Medical Branch, Galveston, USA.
    Background: Atypical mycobacterial infections are uncommon and characterized by a chronic, indolent course before diagnosis. Historically, these infections are associated with marine-related injury and/or immune dysfunction. Our institution has successfully diagnosed and treated an increasing number of these infections. Read More

    Atypical Hand Infections.
    Orthop Clin North Am 2017 Apr 1;48(2):229-240. Epub 2017 Feb 1.
    Department of Hand Surgery, The Hand Center of San Antonio, 21 Spurs Lane, #310, San Antonio, TX 78240, USA.
    Atypical infections of the hand are caused by organisms such as Mycobacterium, fungi, and viruses, and often do not respond to conventional management. They exist within a wide spectrum of presentations, ranging from cutaneous lesions to deep infections such as tenosynovitis and osteomyelitis. Having a high clinical suspicion for atypical hand infections is vital because diagnosis often requires special tests and/or cultures. Read More

    Port-site infections by nontuberculous mycobacterium: A retrospective clinico-microbiological study.
    Int J Mycobacteriol 2017 Jan-Mar;6(1):34-37
    Department of Microbiology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India.
    Background: Port-site infection (PSI) is a prevailing, chronic, nagging, treatment refractory complication of laparoscopic surgery (LS). It neutralizes the advantages of minimally invasive surgery and increases morbidity, treatment cost of patient, leading to loss of confidence on operating surgeon. PSIs are preventable with appropriate preoperative, intraoperative, and postoperative measures. Read More

    Pseudotumoral form of soft tissue tuberculosis of the hand: six cases.
    Pan Afr Med J 2016 21;25:178. Epub 2016 Nov 21.
    Orthopedic surgery and Trauma Department, Maamouri Hospital, Nabeul, Tunisia.
    Musculoskeletal involvement is not uncommon in extra-pulmonary tuberculosis, but the localization in the soft tissue of the hand is very rare. Diagnosis is much more difficult because of the atypical location and non-specific symptoms. We report 6 cases of pseudotumoral form of soft tissue tuberculosis of the hand treated in our department during the past 12 years. Read More

    Miliary Tuberculosis.
    Microbiol Spectr 2017 Mar;5(2)
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Sri Venkateswara Institute of Medical Sciences, Tirupati 517 507, India.
    Miliary tuberculosis (TB) results from a massive lymphohematogenous dissemination of Mycobacterium tuberculosis bacilli and is characterized by tiny tubercles evident on gross pathology resembling millet seeds in size and appearance. The global HIV/AIDS pandemic and widespread use of immunosuppressive drugs and biologicals have altered the epidemiology of miliary TB. Considered to be predominantly a disease of infants and children in the pre-antibiotic era, miliary TB is increasingly being encountered in adults as well. Read More

    Expect the Unexpected: Mycobacterial Infection in Post Total Knee Arthroplasty Patients.
    J Clin Diagn Res 2017 Jan 1;11(1):RD01-RD02. Epub 2017 Jan 1.
    Associate Professor, Department of Orthopaedics, Seth G.S. Medical College and K.E.M. Hospital , Mumbai, Maharashtra, India .
    Orthopaedic Surgeons rarely encounter mycobacterial infections in Post Total Knee Arthroplasty (TKA) patients. We present series of two cases to create awareness among clinicians to expect the unexpected. Tuberculosis typical/ atypical is a hidden culprit in catch clinical situations when chronic infection is Suspected, but the lab investigations are negative in persistently symptomatic patients. Read More

    Mycobacterial Arthritis and Synovitis in Painted Reed Frogs (Hyperolius marmoratus).
    J Comp Pathol 2017 Feb - Apr;156(2-3):275-280. Epub 2017 Feb 21.
    National Zoological Gardens of South Africa, Pretoria, South Africa.
    Several species of atypical mycobacteria have been isolated from wild and captive amphibians. In captive anurans, cutaneous and visceral mycobacteriosis are common and can result in significant mortality, particularly when animals are immunocompromised. Mycobacterial arthritis and synovitis are reported rarely in amphibians. Read More

    Molecular identification and distribution of non-tuberculous mycobacteria isolated from clinical specimens by PCR-sequencing method in West of Iran.
    Clin Respir J 2017 Feb 22. Epub 2017 Feb 22.
    Department of Microbiology, Faculty of Medicine, Kermanshah University of Medical Sciences, Shirudi Shahid Boulevard, Daneshgah Street, Kermanshah, 67148-69914, Iran.
    Background And Aims: Infections by non-tuberculous mycobacteria (NTM) has rapidly increased in recent years, due to high infection rates related to the populations at risk like immunocompromised individuals, patients predisposed by prior pulmonary. The aim of this study was to investigate the presence of NTM in clinical samples and genetic diversity using 16S rRNA and rpoB sequence analysis.

    Methods: A cross-sectional study was conducted on 45 diverse isolates collected from sputum in 2 years 2014-2015 using standard decontamination procedure. Read More

    Coexistent Sarcoidosis and Tuberculosis: A Case Report.
    Respiration 2017 9;93(4):296-300. Epub 2017 Feb 9.
    Department of Medical and Surgical Sciences, Institute of Respiratory Diseases, Azienda Ospedaliero Universitaria Foggia, Foggia, Italy.
    Necrotizing granulomatous diseases of the lungs are usually dependent on a narrow range of differential diagnoses. Tuberculosis (TB) is responsible for the largest number of cases, while necrotizing sarcoidosis is generally considered a rare and easily distinguishable disease substantially based on histological features. However, this entity has become a viable diagnosis in the absence of mycobacteria isolation or when a remarkable clinical improvement cannot be achieved with the combination of anti-TB drugs at full dosage. Read More

    Prospective etiological investigation of community-acquired pulmonary infections in hospitalized people living with HIV.
    Medicine (Baltimore) 2017 Jan;96(4):e5778
    aScientific Division, Instituto de Infectologia Emílio Ribas, São Paulo, SP, Brazil bDepartment of Medicine Solna, Infectious Diseases Unit, Karolinska Institutet cDepartment of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden dEmilio Ribas Institute of Infectious Diseases eDepartment of Infectious Diseases, University of São Paulo Medical School, São Paulo, SP, Brazil.
    The study of the etiological agents of community-acquired pulmonary infections is important to guide empirical therapy, requires constant updating, and has a substantial impact on the prognosis of patients. The objective of this study is to determine prospectively the etiology of community-acquired pulmonary infections in hospitalized adults living with HIV. Patients were submitted to an extended microbiological investigation that included molecular methods. Read More

    Atypical Mycobacterial Infection after Abdominoplasty Overseas: A Case Report and Literature Review.
    Case Rep Infect Dis 2016 27;2016:3642567. Epub 2016 Dec 27.
    Department of Infectious Diseases, Yale New Haven Health System, Bridgeport Hospital, Bridgeport, CT 06610, USA.
    Increasing number of medical tourists travel internationally for cosmetic procedures. Lipotourism is a form of medical tourism becoming popular among patients of developed countries due to the cost efficiency of cosmetic procedures when performed in developing nations. There is a paucity of data on quality, safety, and risks involved with these surgeries. Read More

    A Case of Surgical Site Infection Caused by Mycobacterium fortuitum, following Herniorrhaphy.
    J Clin Diagn Res 2016 Nov 1;10(11):DD01-DD02. Epub 2016 Nov 1.
    Associate Professor, Department of General Surgery, Indira Gandhi Medical College and Research Institute , Puducherry, India .
    Rapidly Growing Mycobacteria (RGM) are opportunistic pathogens found in the environment. Mycobacterium fortuitum, M. chelonae and M. Read More

    Mycobacterium haemophilum: A report of cutaneous Infection in a Patient with end-stage renal disease.
    Int J Mycobacteriol 2016 Dec 9;5 Suppl 1:S236. Epub 2016 Nov 9.
    Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:
    Introduction: Mycobacterium haemophilum is a slow-growing nontuberculous mycobacterium (NTM) that can cause ulcerating cutaneous or subcutaneous nodular skin lesions in immunocompromised and immunocompetent patients. Acid-fast staining cannot distinguish NTM from M. tuberculosis; culturing at two temperatures with iron-supplemented media and polymerase chain reaction (PCR) are needed for optimal detection of M. Read More

    IL-12Rβ1 defect presenting with massive intraabdominal lymphadenopathy due to Mycobacterium intracellulare: A case report.
    Asian Pac J Allergy Immunol 2016 Dec 12. Epub 2016 Dec 12.
    Marmara University School of Medicine, Department of Pediatrics, Division of Pediatric Infectious Diseases, Istanbul, Turkey.
    Infections due to non-tuberculous mycobacteria species are problematic for immunodeficient individuals. Mendelian susceptibility to mycobacterial diseases (MSMD) defines a group of genetic defects affecting cellular interactions and the interferon (IFN)-γ pathway. Patients with MSMD may present with a disseminated infection resulting from the Bacillus Calmette-Guerin vaccine, Mycobacterium tuberculosis complex, environmental nontuberculous mycobacteria or Salmonella species. Read More

    Pulmonary Mycobacterium kansasii disease in immunocompetent host: Treatment outcomes with short-course chemotherapy.
    Indian J Med Microbiol 2016 Oct-Dec;34(4):516-519
    Department of Clinical Research, National Institute for Research in Tuberculosis, Chennai, Tamil Nadu, India.
    Mycobacterium kansasii, most virulent of all atypical mycobacteria, causes pulmonary disease identical to the disease caused by Mycobacterium tuberculosis. Early identification of the species and prompt initiation of treatment for M. kansasii is necessary to prevent morbidity and mortality due to this disease. Read More

    Clinical implications of Mycobacterium chimaera detection in thermoregulatory devices used for extracorporeal membrane oxygenation (ECMO), Germany, 2015 to 2016.
    Euro Surveill 2016 Nov;21(46)
    Institute of Medical Microbiology and Hygiene, Saarland University, Homburg/Saar, Germany.
    Mycobacterium chimaera, a non-tuberculous mycobacterium, was recently identified as causative agent of deep-seated infections in patients who had previously undergone open-chest cardiac surgery. Outbreak investigations suggested an aerosol-borne pathogen transmission originating from water contained in heater-cooler units (HCUs) used during cardiac surgery. Similar thermoregulatory devices are used for extracorporeal membrane oxygenation (ECMO) and M. Read More

    Novel Mutation of Interferon-γ Receptor 1 Gene Presenting as Early Life Mycobacterial Bronchial Disease.
    J Investig Med High Impact Case Rep 2016 Oct-Dec;4(4):2324709616675463. Epub 2016 Nov 8.
    Children's National Medical Center, Washington, DC, USA; George Washington University, Washington, DC, USA.
    Mendelian susceptibility to mycobacterial diseases (MSMD) are a spectrum of inherited disorders characterized by localized or disseminated infections caused by atypical mycobacteria. Interferon-γ receptor 1 (IFNGR1) deficiency was the first identified genetic disorder recognized as MSMD. Mutations in the genes encoding IFNGR1 can be recessive or dominant and cause complete or partial receptor deficiency. Read More

    Mycobacterium chelonae in a tectonic corneal graft.
    Oman J Ophthalmol 2016 Sep-Dec;9(3):177-178
    Sussex Eye Hospital, Brighton, East Sussex, BN2 5BF, UK.
    Atypical mycobacterial infections of the cornea can present with nonspecific inflammatory changes and graft rejection, with no obvious focus to culture and a subsequent delay to diagnosis. These pathogens are well documented in the literature following laser-assisted in situ keratomileusis but have rarely been described following corneal transplant surgery. We report a single case of Mycobacterium chelonae keratitis 1 year after tectonic keratoplasty. Read More

    Imaging in extrapulmonary tuberculosis.
    Int J Infect Dis 2017 Mar 10;56:237-247. Epub 2016 Nov 10.
    Department of Nuclear Medicine, of Nuclear Medicine, UCLH NHS Foundation Trust, 235 Euston Road, London NW1 2BU, UK. Electronic address:
    Tuberculosis (TB) remains a major global public health problem, with 1.5 million deaths annually worldwide. One in five cases of TB present as extrapulmonary TB (EPTB), posing major diagnostic and management challenges. Read More

    Abdominal tuberculosis: an old disease surprising young doctors.
    BMJ Case Rep 2016 Nov 2;2016. Epub 2016 Nov 2.
    Department of Surgery-Cirurgia B, Hospital Professor Doutor Fernando Fonseca EPE, Amadora, Portugal.
    Tuberculosis remains a worldwide public health concern. Atypical extrapulmonary presentations may delay the diagnosis and treatment. We present the case of an adult woman admitted to the emergency department with bowel obstruction. Read More

    Tuberculous Fasciitis in Polymyositis: A Rare Case of Extrapulmonary Tuberculosis.
    Intern Med 2016;55(21):3205-3209. Epub 2016 Nov 1.
    Department of Nephrology, Osaka Rosai Hospital, Japan.
    A 71-year-old woman with polymyositis presenting with left thigh pain and an intermittent fever was admitted to Osaka Rosai Hospital. We initially diagnosed that her pain and fever were caused by a soft tissue infection because her polymyositis was controlled. She did not respond to various antibiotic therapies. Read More

    [Pulmonary tuberculosis among hospitalized patients in Brazzaville: impact of late diagnosis of HIV infection on radiographic abnormalities].
    Pan Afr Med J 2016 20;24:259. Epub 2016 Jul 20.
    Faculté des Sciences de la Santé, Université Marien NGOUABI, Congo; Service de Pneumologie, CHU de Brazzaville-Congo.
    The aim was to describing the different radiographic features of pulmonary tuberculosis according to the degree of immunosuppression in HIV patients. We report a retrospective study of 80 untreated HIV-positive patients with pulmonary tuberculosis hospitalized in the Pneumo-Phthisiology Department in Brazzaville from January 2013 to January 2014. Our sample consisted of 44 women (55%) and 36 men (45%), the sex ratio was 0. Read More

    Hoarse voice: a rare presentation of tuberculosis lymphadenitis.
    BMJ Case Rep 2016 Oct 24;2016. Epub 2016 Oct 24.
    Imperial College Healthcare NHS Trust, London, UK.
    A man aged 37 years from Indian descent presented to an inner city London hospital with hoarseness of voice, fatigue, night sweats and a 2 kg weight loss. Laryngoscopy demonstrated a left vocal fold palsy. Extensive investigations were undertaken with disseminated malignancy being primarily investigated. Read More

    Leprae reaction resembling rheumatologic disease as presenting feature of leprosy.
    Int J Rheum Dis 2016 Oct 26;19(10):1035-1038. Epub 2016 Jul 26.
    Rheumatology Division, Hospital Selayang, Batu Caves, Malaysia.
    Leprosy is a chronic granulomatous infection caused by Mycobacterium leprae with predominant involvement of skin and nerves. We present a 70-year-old man with leprosy whose initial presentation resembled rheumatologic disease, due to leprae reaction. He presented with an 8-week history of worsening neuropathic pain in the right forearm, associated with necrotic skin lesions on his fingers that had ulcerated. Read More

    Mycobacterium avium Infection of Nasal Septum in a Diabetic Adult: A Case Report.
    Head Neck Pathol 2016 Dec 20;10(4):552-555. Epub 2016 Jun 20.
    Department of Pathology, Creighton University School of Medicine, Omaha, NE, USA.
    Mycobacterium avium complex (MAC) is primarily a pulmonary pathogen that affects individuals who are immune deficient or immunocompromised. In this report, we describe a very rare case of MAC infection clinically presenting as a nasal polyp in a patient with type 2 diabetes mellitus. This case illustrates an atypical anatomic location for MAC, the anterior nasal septum in nasal cavity, as well as often overlooked cause of immune compromise, diabetes mellitus. Read More

    A longitudinal study of the Mycobacterium avium subspecies paratuberculosis infection status in young goats and their mothers.
    Vet Microbiol 2016 Nov 27;195:9-16. Epub 2016 Aug 27.
    UR1282 Infectiologie et Santé Publique, INRA Centre Val de Loire, 37380 Nouzilly, France. Electronic address:
    The dynamics between Mycobacterium avium subspecies paratuberculosis (MAP) infection and the immune response of goats naturally exposed to MAP were studied in a herd where the clinical expression of paratuberculosis had been observed. Four generations of goats were observed over a 33-month period: mothers of three different generations (G1, G2, G3) and their daughters, generation 4 (G4). A MAP infection status was defined according to the combined results of an IFN-γ assay, antibody response, faecal culture and post-mortem examination. Read More

    Mycobacterium chelonae-abscessus Complex Infection After Flatfoot Reconstruction.
    J Foot Ankle Surg 2016 Nov - Dec;55(6):1327-1332. Epub 2016 Feb 24.
    Attending Surgeon, Inova Fairfax Hospital, Private Practice, Fairfax, VA.
    Mycobacterium infections involving tuberculosis in the foot are rare but cases are readily available in published studies. Atypical or nontuberculosis mycobacterium foot infections are rare, especially those involving the soft tissue and bone, and have been infrequently reported. To date, no case reports involving atypical mycobacterium infection after elective foot surgery have been reported. Read More

    Musculosceletal tuberculosis with involvement of tendon sheaths and formation of synovial cyst.
    Pneumonol Alergol Pol 2016 ;84(5):278-82
    Department of Lung Diseases and Tuberculosis, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Poland.
    Due to an increasing amount of patients on immunosuppressive treatment, the number of tuberculosis (TB) of atypical course and extrapulmonary tuberculosis cases increase. Locomotor system is a place of every fifth case of extrapulmonary TB. Because of lack of characteristic symptoms, as well as rare co-occurrence of active lung lesions in radiological imaging, proper diagnosis is hard to establish. Read More

    Atypical imaging of spinal tuberculosis: a case report and review of literature.
    Pan Afr Med J 2016 31;24:101. Epub 2016 May 31.
    Department of Orthopedics, Xi'an Chest Hospital, Xi'an, China.
    This is a case report of spinal tuberculosis combined with sacroiliac joint tuberculosis, pulmonary tuberculosis, chest wall tuberculosis and tuberculous pleurisy and the image of the patient is rare, special and not typical and it looks like a halo sign. It has an important reference value for the diagnosis of spine tuberculosis although it is a rare imaging manifestation and diagnosis was confirmed by pathology after the surgery. Therefore atypical imaging is often appeared in clinical practice and it is meaningful and necessary for the diagnosis of atypical spinal tuberculosis combined with multiple organ tuberculosis. Read More

    [Pulmonary infection with Mycobacterium malmoense. Difficulties in diagnosis and treatment].
    Rev Mal Respir 2017 Mar 14;34(3):257-261. Epub 2016 Sep 14.
    Service de pneumologie et de réanimation respiratoire, CHU Sud, 80080 Amiens, France.
    Introduction: Pulmonary infection due to Mycobacterium malmoense can be difficult to diagnose. These difficulties can be responsible for a delay in the implementation of optimal treatment. Moreover, the treatment is not standardized. Read More

    [Opportunistic infections and sarcoidosis].
    Rev Med Interne 2017 May 14;38(5):320-327. Epub 2016 Sep 14.
    Service de médecine interne, hôpital de la Croix-Rousse, 103, grande rue de la Croix-Rousse, 69004 Lyon, France; Université Claude-Bernard-Lyon 1, 69004 Lyon, France.
    Opportunistic infections (OI) are uncommon in sarcoidosis (1 to 10%) and mostly occur in patients with previously diagnosed disease or can rarely be the presenting manifestation. The most common OIs are, in descending order: aspergillosis, cryptococcosis, and mycobacterial infections. Treatment with corticosteroids is the most frequent risk factor for OI occurrence during sarcoidosis but immunosuppressive drugs and therapy with anti-TNFα are also risk factors. Read More

    Mycobacterium smegmatis infection of a prosthetic total knee arthroplasty.
    IDCases 2016 1;5:80-2. Epub 2016 Aug 1.
    Metro Infectious Disease Consultants, McLaren Macomb Hospital, 1000 Harrington Blvd. Mount Clemens, MI 48043, United States.
    The most common organisms causing prosthetic knee joint infections are staphylococci. However, arthroplasty infections with atypical microbial pathogens, such as Mycobacteria can occur. Due to the rarity of mycobacterial prosthetic joint infections, diagnosis, treatment, and management of these atypical infections represent a clinical challenge. Read More

    [Genital tuberculosis: atypical manifestation in the pregnancy. Case report].
    Ginecol Obstet Mex 2016 May;84(5):314-8
    Background: In the last years has been an increase in cases of tu- berculosis, representing a global health problem that is also reflected in an increased of cases in pregnant population. Especially in developed countries has been observed a direct relation with VIH patients,and groups of immigrants from countries where the infection is endemic. Tuberculous disease during pregnancy presents good outcome if it is diagnosed and treated properly. Read More

    Multiple Cavitary Pulmonary Nodules Caused by Mycobacterium intracellulare.
    Korean J Fam Med 2016 Jul 21;37(4):248-52. Epub 2016 Jul 21.
    Department of Internal Medicine, Daejeon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Daejeon, Korea.
    Nontuberculous mycobacteria (NTM) have been increasingly recognized as an important cause of chronic pulmonary infections. The Mycobacterium avium complex (MAC), which is composed of two species, Mycobacterium avium and Mycobacterium intracelluare, is the most commonly encountered pathogen associated with NTM lung disease. MAC pulmonary infection typically presents in a fibrocavitary form or a nodular bronchiectatic form. Read More

    Monoarticular Poncet Disease after Pulmonary Tuberculosis: A Rare Case Report and Review of Literature.
    Perm J Summer 2016;20(3). Epub 2016 Jul 15.
    Orthopedician at the University College of Medical Sciences and Guru Tag Bahadur Hospital in Dilshad Garden, Delhi, India.
    Introduction: Tuberculosis is a major health problem worldwide, more so in Asian countries and especially India. Being a communicable disease, it can affect the lives of many people. Tuberculosis has varied manifestations and can affect almost every part of the human body. Read More

    Pericardial effusion with Mycobacterium avium complex in HIV-infected patients.
    BMJ Case Rep 2016 Jul 7;2016. Epub 2016 Jul 7.
    Department of General Medicine, East Lancashire Hospitals NHS Trust, Blackburn, UK.
    Disseminated atypical Mycobacterium infection is a well-known opportunistic infection in HIV-infected patients with advanced immune deficiency before the introduction of combination antiretroviral therapy. Although the disseminated infection is now rare, few cases of localised infections are reported. A 38-year-old man was diagnosed with HIV infection during asymptomatic sexual health screening. Read More

    Atypical Pleural Fluid Profiles in Tuberculous Pleural Effusion: Sequential Changes Compared with Parapneumonic and Malignant Pleural Effusions.
    Intern Med 2016 1;55(13):1713-9. Epub 2016 Jul 1.
    Department of Internal Medicine, Kyungpook National University, School of Medicine, Republic of Korea.
    Objective Although tuberculous pleural effusion (TPE) is commonly characterized by lymphocytic predominance and high adenosine deaminase (ADA) levels, it may present with neutrophilic predominance or low ADA levels, which are more commonly found in parapneumonic effusion (PPE) or malignant pleural effusion (MPE), respectively. A few studies have observed that the atypical pleural fluid profiles of these cases of TPE may resolve at follow-up thoracentesis. However, these observations were incompletely analyzed and lacked comparison with proper control groups. Read More

    [Latent-disseminated tuberculosis revealed by atypical skin ulcerations].
    Ann Dermatol Venereol 2016 Oct 21;143(10):616-621. Epub 2016 Jun 21.
    Service de dermatologie, hôpital Saint-André, CHU de Bordeaux, rue Jean-Burguet, 33076 Bordeaux, France. Electronic address:
    Introduction: Cutaneous tuberculosis (CT) is rare in industrialized countries. Given the clinicopathological polymorphism and the difficulty of isolating the pathogen, diagnosis can be difficult. The condition may be associated with other known locations of the disease or in rare cases, it may be a tell-tale sign, as in our case, in which leg ulcers revealed paucisymptomatic disseminated tuberculosis. Read More

    Repeated administration of ethambutol in therapeutic dose causes testes alteration and spermatogenesis disruption in Wistar rats.
    Hum Exp Toxicol 2017 May 22;36(5):520-533. Epub 2016 Jun 22.
    1 General Toxicology Department, SI "Institute of Pharmacology & Toxicology NAMS of Ukraine," Kyiv, Ukraine.
    Ethambutol (EMB) is conventionally used to treat tuberculosis and atypical Mycobacterium infections in combination with other antimycobacterial drugs. Eventually, EMB testicular toxicity has not been explored extensively yet. The aim of the study is to evaluate testicular toxicity of EMB. Read More

    Patients with Tuberculosis Have a Dysfunctional Circulating B-Cell Compartment, Which Normalizes following Successful Treatment.
    PLoS Pathog 2016 Jun 15;12(6):e1005687. Epub 2016 Jun 15.
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.
    B-cells not only produce immunoglobulins and present antigens to T-cells, but also additional key roles in the immune system. Current knowledge on the role of B-cells in infections caused by intracellular bacteria is fragmentary and contradictory. We therefore analysed the phenotypical and functional properties of B-cells during infection and disease caused by Mycobacterium tuberculosis (Mtb), the bacillus causing tuberculosis (TB), and included individuals with latent TB infection (LTBI), active TB, individuals treated successfully for TB, and healthy controls. Read More

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