Dual-Specificity Phosphatase 12 Targets p38 MAP Kinase to Regulate Macrophage Response to Intracellular Bacterial Infection.
- Sharol Su Lei Cho,
- Jian Han,
- Sharmy J James,
- Chin Wen Png,
- Madhushanee Weerasooriya,
- Sylvie Alonso,
- Yongliang Zhang
Front Immunol 2017 9;8:1259. Epub 2017 Oct 9.
Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, Singapore, Singapore.
The mitogen-activated protein kinase (MAPK) cascades are activated in innate immune cells such as macrophages upon the detection of microbial infection, critically regulating the expression of proinflammatory cytokines and chemokines such as TNF-α, IL-6, and MCP-1. As a result, activation of MAPKs is tightly regulated to ensure appropriate and adequate immune responses. Dual-specificity phosphatases (DUSPs) are a family of proteins which specifically dephosphorylates threonine and tyrosine residues essential for MAPK activation to negatively regulate their activation. Read More