3,589 results match your criteria Atypical Mycobacterial Diseases


Non-tuberculous mycobacterial lung disease in patients with bronchiectasis: perceived risk, severity and guideline adherence in a European physician survey.

BMJ Open Respir Res 2020 Apr;7(1)

Insmed Inc, Bridgewater, New Jersey, USA.

Background: Patients with bronchiectasis are at increased risk of developing non-tuberculous mycobacteria lung disease (NTM-LD), and published guidelines recommend regular testing for NTM infection in this patient population.

Objective: This study aimed to survey physicians managing patients with bronchiectasis to understand the perceived risk of NTM to their patients, perceived disease severity and frequency of testing for NTM.

Methods: The study comprised an online survey of hospital-based physicians in the UK, Germany, Italy, France and the Netherlands. Read More

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http://dx.doi.org/10.1136/bmjresp-2019-000498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204844PMC

[Pathological anatomy of tuberculosis in the presence of human immunodeficiency virus infection].

Arkh Patol 2020 ;82(2):12-19

S.P. Botkin Clinical Infectious Diseases Hospital, Saint Petersburg, Russia.

Tuberculosis occupies a leading position among secondary infections in the structure of mortality in HIV-positive patients. Moreover, the concurrence of these diseases frequently makes a morphological diagnosis most difficult due to the atypical course of tuberculosis (TB) in the presence of immunosuppression.

Aim: to assess the clinical and morphological characteristics of concurrent TB/HIV infection. Read More

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http://dx.doi.org/10.17116/patol20208202112DOI Listing

Disseminated Disease by Mycobacterium abscessus and Mycobacterium celatum in an Immunocompromised Host.

Am J Case Rep 2020 Apr 7;21:e921517. Epub 2020 Apr 7.

Division of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Hospital, University of Catania, Catania, Italy.

BACKGROUND Nontuberculous mycobacteria (NTM) are environmental pathogens that cause an increasing number of diseases, in particular in immunosuppressed patients. Diagnosing NTM infections may be difficult because clinical presentation is unspecific and resembles other conditions such as tuberculosis, lymphomas, or septicemia. CASE REPORT We report the case of a 62-year-old male with a recent history of autologous bone marrow transplantation for a follicular lymphoma admitted to our department for long-lasting remittent fever and abscess-like splenic nodules. Read More

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http://dx.doi.org/10.12659/AJCR.921517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161942PMC

Disseminated Mycobacterium simiae infection in a patient with adult-onset immunodeficiency due to anti-interferon-gamma antibodies - a case report.

BMC Infect Dis 2020 Apr 1;20(1):258. Epub 2020 Apr 1.

National Hospital of Sri Lanka, Colombo, Sri Lanka.

Background: Mycobacterial species other than Mycobacterium tuberculosis and Mycobacterium leprae are generally free-living organisms and Mycobacterium simiae is one of the slowest growing Non-tuberculous mycobacteria. This is the first case report of Mycobacterium simiae infection in Sri Lanka and only very few cases with extrapulmonary manifestation reported in the literature.

Case Presentation: A 24-year-old, previously healthy Sri Lankan male presented with generalized lymphadenopathy with discharging sinuses, evening pyrexia, weight loss, poor appetite and splenomegaly. Read More

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http://dx.doi.org/10.1186/s12879-020-04984-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110743PMC

Flare or foe? - infection mimicking rheumatoid arthritis tenosynovitis: case report and literature review.

BMC Rheumatol 2020 16;4:11. Epub 2020 Mar 16.

1Department of Nephrology and Rheumatology, University Medical Center Göttingen, Robert-Koch-Str. 40, D-37075 Göttingen, Germany.

Background: Rheumatoid arthritis is the most common type of inflammatory arthritis affecting about 1% of the population. With the advent of disease-modifying anti-rheumatic drugs the disease can be well controlled in many cases. Patients, however, are prone to developing infectious complications. Read More

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http://dx.doi.org/10.1186/s41927-020-0114-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074991PMC

The effects of sildenafil on ciliary beat frequency in patients with pulmonary non-tuberculous mycobacteria disease: phase I/II trial.

BMJ Open Respir Res 2020 Mar;7(1)

Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA.

Rationale: Pulmonary non-tuberculous mycobacterial (PNTM) disease has increased over the past several decades, especially in older women. Abnormal mucociliary clearance and abnormal nasal nitric oxide (nNO) have been associated with PNTM disease in other patient cohorts. Mucociliary clearance can be affected by NO-cyclic guanosine monophosphate signalling and, therefore, modulation of the pathway may be possible with phosphodiesterase inhibitors such as sildenafil as a novel therapeutic approach. Read More

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http://dx.doi.org/10.1136/bmjresp-2020-000574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069259PMC

Structural insight into the recognition of pathogen-derived phosphoglycolipids by C-type lectin receptor DCAR.

J Biol Chem 2020 Apr 5;295(17):5807-5817. Epub 2020 Mar 5.

Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Suita 565-0871, Japan

The C-type lectin receptors (CLRs) form a family of pattern recognition receptors that recognize numerous pathogens, such as bacteria and fungi, and trigger innate immune responses. The extracellular carbohydrate-recognition domain (CRD) of CLRs forms a globular structure that can coordinate a Ca ion, allowing receptor interactions with sugar-containing ligands. Although well-conserved, the CRD fold can also display differences that directly affect the specificity of the receptors for their ligands. Read More

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http://dx.doi.org/10.1074/jbc.RA120.012491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186165PMC

The immunology of other mycobacteria: M. ulcerans, M. leprae.

Semin Immunopathol 2020 Feb 25. Epub 2020 Feb 25.

Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.

Mycobacterial pathogens can be categorized into three broad groups: Mycobacterium tuberculosis complex causing tuberculosis, M. leprae and M. lepromatosis causing leprosy, and atypical mycobacteria, or non-tuberculous mycobacteria (NTM), responsible for a wide range of diseases. Read More

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http://dx.doi.org/10.1007/s00281-020-00790-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224112PMC
February 2020

Non-tuberculous mycobacteria profiles and their anti-mycobacterial resistance at a major medical center in Lebanon.

J Infect Dev Ctries 2019 07 31;13(7):612-618. Epub 2019 Jul 31.

Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

Introduction: Infection with non-tuberculosis mycobacteria (NTM) has been on the rise globally causing a wide spectrum of respiratory and extrapulmonary infections in humans. Studies on these pathogens from the Middle-East including Lebanon are scarce.

Methodology: This retrospective study addresses the approach used for investigation, speciation and antimicrobial resistance (AMR) profiles of recovered NTM isolates from respiratory sources at a major tertiary care center in Lebanon during two periods (2003-2007 and 2013-2017). Read More

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http://dx.doi.org/10.3855/jidc.11028DOI Listing

Application of whole-genome sequencing in a case study of renal tuberculosis in a child.

BMC Infect Dis 2020 Feb 5;20(1):105. Epub 2020 Feb 5.

Latvian Biomedical Research and Study Centre, Ratsupites Str 1, k-1, Riga, LV-1067, Latvia.

Background: Urogenital tuberculosis (TB) is rare in children and usually develops due to reactivation of the foci in the genitourinary tract after the latency period following initial infection. Urogenital TB in children has no pathognomonic clinical features that can result in overlooking or misdiagnosing this clinical entity. Here, we report important findings regarding the pathogenesis and transmission of TB by using genotyping and whole-genome sequencing (WGS) in a study of renal TB case in a child. Read More

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http://dx.doi.org/10.1186/s12879-020-4832-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003358PMC
February 2020

Surgical management of atypical mycobacterial cervical lymphadenitis in an outbreak of odontological infection.

Int J Pediatr Otorhinolaryngol 2020 Apr 15;131:109882. Epub 2020 Jan 15.

CHOC Children's Hospital, Orange, CA, USA.

Introduction: We report on our experience with surgical management of nosocomial Mycobacterium abscessus cervical lymphadenitis in the setting of an epidemic linked to a dental practice in the community.

Methods: This is an observational case series of children who required surgical treatment of cervical lymphadenitis as part of multidisciplinary management of nosocomial M. abscessus infections. Read More

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http://dx.doi.org/10.1016/j.ijporl.2020.109882DOI Listing

Looking beyond Typical Treatments for Atypical Mycobacteria.

Antibiotics (Basel) 2020 Jan 3;9(1). Epub 2020 Jan 3.

i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.

The genus comprises not only the deadliest of bacterial pathogens, , but several other pathogenic species, including and . The incidence of infections caused by atypical or nontuberculous mycobacteria (NTM) has been steadily increasing, and is associated with a panoply of diseases, including pulmonary, soft-tissue, or disseminated infections. The treatment for NTM disease is particularly challenging, due to its long duration, to variability in bacterial susceptibility profiles, and to the lack of evidence-based guidelines. Read More

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http://dx.doi.org/10.3390/antibiotics9010018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168257PMC
January 2020

Mycobacterium chelonae, an 'atypical' cause of an LVAD driveline infection.

Int J Infect Dis 2020 Mar 8;92:127-129. Epub 2020 Jan 8.

Department of Cardiology, Thorax Centre, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands. Electronic address:

We describe the first patient with a left ventricular assist device (LVAD) driveline infection caused by Mycobacterium chelonae presenting with persistent infection despite conventional antibiotics. Treatment was successful with surgical debridement, driveline exit relocation, and a 4-month period of antibiotics. In the case of a culture-negative LVAD driveline infection, non-tuberculous mycobacteria should be considered. Read More

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http://dx.doi.org/10.1016/j.ijid.2020.01.002DOI Listing

Tuberculosis in elderly in the Czech Republic.

Epidemiol Mikrobiol Imunol 2019 ;68(4):184-190

Introduction: The incidence of tuberculosis (TB) in the Czech Republic (CR) is decreasing since 1960s. (1965: 76.9; 1975: 60. Read More

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January 2020

Pulmonary Infection Caused by Mycobacterium terrae: A Case Report and Literature Review.

Cureus 2019 Nov 25;11(11):e6228. Epub 2019 Nov 25.

Critical Care, United General Hospital, Houston, USA.

infection can cause progressive debilitating disease. A case of a 63-year-old man with localized pulmonary infection characterized by extensive, thick-walled cavitary lesions is presented. A pneumonectomy was considered as definitive treatment, but the patient would not have tolerated the procedure given his severe deconditioning. Read More

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http://dx.doi.org/10.7759/cureus.6228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929248PMC
November 2019

[Campylobacter jejuni bacteremia in a patient with HIV infection in AIDS stage].

Rev Chilena Infectol 2019 Oct;36(5):663-666

Hospital San Juan de Dios, Santiago, Chile.

Bacteremia is an atypical presentation of Campylobacter jejuni infection and it is more frequent in patients with advanced inmunodepression due to HIV or other sistemic diseases. Because of the highly active antiretroviral therapy, in the last decades the number of cases had declined. We report a case of a homeless woman with HIV in C3 stage who was diagnosed with the bacteremia during her hospitalization for pulmonary tuberculosis, and a brief review of C. Read More

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http://dx.doi.org/10.4067/S0716-10182019000500663DOI Listing
October 2019

Serum proteome profiles to differentiate Crohn disease from intestinal tuberculosis and primary intestinal lymphoma: A pilot study.

Medicine (Baltimore) 2019 Dec;98(50):e18304

Department of Gastroenterology, First Affiliated Hospital, Zhejiang University School of Medicine.

The differential diagnosis of Crohn disease (CD) from intestinal tuberculosis (ITB) and primary intestinal lymphoma (PIL) is challenging in patients who exhibit atypical clinical characteristics. The aim of the present study was to explore the serum proteome profiles of CD, PIL and ITB and to identify their differentiations.Treatment-naïve patients with CD (n = 10), PIL (n = 10) and ITB (n = 10) were enrolled in the present study. Read More

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http://dx.doi.org/10.1097/MD.0000000000018304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6922555PMC
December 2019

Pediatric Ventriculoperitoneal Shunt Infection: The Role of Shunt Tract Debridement in Mycobacterium abscessus Eradication.

J Craniofac Surg 2020 Jan/Feb;31(1):278-282

Division of Plastic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine.

Ventricular shunt infections caused by nontuberculous mycobacteria are uncommon, and those caused by Mycobacterium abscessus are particularly rare. This mycobacterium is intrinsically resistant to first-line anti-tuberculous drugs and is considered the most pathogenic of the atypical, rapidly growing mycobacteria. Given the paucity of reported M. Read More

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http://dx.doi.org/10.1097/SCS.0000000000006061DOI Listing

Tubercular involvement of the lateral malleolus and adjacent calcaneus: presentation of a rare case and review of the literature.

BMJ Case Rep 2019 Dec 10;12(12). Epub 2019 Dec 10.

Orthopaedics, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Osteoarticular tuberculosis (TB), despite being on the wane in the developed world, stays a problem of significance in the developing world. The issue is compounded by unusual presentations, inadequate diagnostic skills and limited understanding of its management. For foot infections, despite an increased awareness, many patients may be misdiagnosed, with associated treatment delays. Read More

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http://dx.doi.org/10.1136/bcr-2019-231533DOI Listing
December 2019

[Atypical Localization of a Case of Leprosy in Lomé (Togo)].

Bull Soc Pathol Exot 2019 ;112(3):133-136

Service de dermatologie et IST, CHU Sylvanus Olympio, Université de Lomé, Togo.

This was a 50-year-old woman with a selling activity living in Lomé who came for a consultation in March 2016 for a facial flushing that had been going on for 2 months without pain or pruritus. On examination, there was a single, erythemato-squamous closet of the right hemiface. There was no infiltration of the right ear. Read More

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http://dx.doi.org/10.3166/bspe-2019-0095DOI Listing

Undernutrition is associated with perturbations in T cell-, B cell-, monocyte- and dendritic cell- subsets in latent Mycobacterium tuberculosis infection.

PLoS One 2019 10;14(12):e0225611. Epub 2019 Dec 10.

National Institute of Health-NIRT-International Center for Excellence in Research, Chennai, India.

Undernutrition, as described by low body mass index (BMI), is a foremost risk factor for the progression of active Tuberculosis (TB). Undernutrition is also known to impact the baseline frequencies of innate and adaptive immune cells in animal models. To verify whether undernutrition has any influence on the baseline frequencies of immune cells in latent Mycobacterium tuberculosis infection (LTBI), we examined the frequencies of T cell-, B cell, monocyte- and dendritic cell (DC)- subsets in individuals with LTBI and low BMI (LBMI) and contrasted them with LTBI and normal BMI (NBMI) groups. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0225611PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6903744PMC

Case of atypical cutaneous infection in patient of systemic lupus erythematosus after cyclophosphamide therapy.

BMJ Case Rep 2019 Dec 8;12(12). Epub 2019 Dec 8.

Rheumatology, East Kent Hospitals University NHS Foundation Trust, Canterbury, Kent, UK.

is one of the rapidly growing non-tuberculous mycobacteria that can be isolated from water, soils and aerosols. Localised infections have been reported associated with tattoo parlours, pedicures and cosmetic procedures. But disseminated infection is usually associated with individuals who are immunocompromised, predominantly affecting limbs but sparing abdomen and back. Read More

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http://dx.doi.org/10.1136/bcr-2019-231930DOI Listing
December 2019

Cutaneous Mycobacterium Marinum Infection (Fish Tank Granuloma) in a Renal Transplant Recipient: Case Report and Literature Review.

Cureus 2019 Oct 28;11(10):e6013. Epub 2019 Oct 28.

Dermatology, Edouard Herriot Hospital, Lyon, FRA.

Atypical mycobacterioses are unusual infections of the skin and other organs caused by non-tuberculous mycobacteria. Fish tank granuloma and swimming pool granuloma are two forms of atypical mycobacterioses caused by Mycobacterium marinum. So far, only a few cases of these infections have been reported in organ transplant patients, and these usually are more severe when compared with atypical mycobacterioses in immunocompetent hosts. Read More

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http://dx.doi.org/10.7759/cureus.6013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881089PMC
October 2019

Profile of patients with pulmonary non-tuberculous mycobacterial disease mimicking pulmonary tuberculosis.

Indian J Tuberc 2019 Oct 7;66(4):461-467. Epub 2019 May 7.

Government Hospital of Thoracic Medicine, Tambaram, Chennai, India.

Introduction: With the introduction of newer molecular diagnostic tools, an increasing number of Non-tuberculous Mycobacteria (NTM) affecting the respiratory system and mimicking symptoms of pulmonary tuberculosis (PTB) are being identified. They may be misdiagnosed and treated as PTB, often categorized as treatment failures if they do not respond to treatment. This manuscript aims to characterize patients with pulmonary NTM disease. Read More

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http://dx.doi.org/10.1016/j.ijtb.2019.04.013DOI Listing
October 2019

Atypical mycobacteria diagnosed by bone marrow biopsy in an HIV-positive patient.

Ann Hematol 2020 Jan 6;99(1):183-184. Epub 2019 Dec 6.

Pathology Unit, Azienda Ospedaliera Santa Maria di Terni, University of Perugia, Terni, Italy.

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http://dx.doi.org/10.1007/s00277-019-03880-yDOI Listing
January 2020

Mycobacterial Infections With Ruxolitinib: A Retrospective Pharmacovigilance Review.

Clin Lymphoma Myeloma Leuk 2020 Jan 26;20(1):18-23. Epub 2019 Aug 26.

Houston Methodist Cancer Center/Weill Cornell Medicine, Houston, TX. Electronic address:

Background: Ruxolitinib is a selective Janus kinase inhibitor (JAKI) 1/2 approved for the treatment of myelofibrosis (MF) and polycythemia vera (PV). These patients may be at risk for developing opportunistic infections. We assessed the number of patients that developed typical (Mycobacterium tuberculosis [MTB]) and atypical mycobacterial infections (AMI) while on treatment with ruxolitinib by utilizing the United States Food and Drug Administration (FDA) adverse events reporting system (FAERS). Read More

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http://dx.doi.org/10.1016/j.clml.2019.08.008DOI Listing
January 2020
4 Reads

Atypical Mycobacterial Infections After Plastic Surgery Procedures Abroad: A Multidisciplinary Algorithm for Diagnosis and Treatment.

Ann Plast Surg 2020 03;84(3):257-262

Department of Plastic Surgery, University of Maryland Medical Center.

Background: The recent rise in medical tourism, especially for cosmetic procedures, has been mirrored by an increase in the incidence of infections with Mycobacterium abscessus, which is an atypical mycobacterium that is ubiquitous in aquatic environments. M. abscessus soft tissue infections arise from the use of improperly sterilized water and surgical equipment during surgical procedures, and these infections have devastating consequences if not promptly treated. Read More

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http://dx.doi.org/10.1097/SAP.0000000000002061DOI Listing

Atypical Mycobacterial Infection Arising Amid Corticosteroid Therapy for Livedoid Vasculopathy.

Case Rep Dermatol Med 2019 7;2019:1840280. Epub 2019 Oct 7.

Department of Dermatology, University of Toledo Medical Center, 3000 Arlington Avenue, Toledo, OH 43614, USA.

Patients who suffer from rare skin diseases may try numerous therapies with many potential side effects before achieving remission. Livedoid vasculopathy (LV) is one such rare disease that lacks a definitive treatment as evidenced by randomized controlled trials. Although corticosteroids help reduce the pain flares associated with LV, they come at the risk of immunosuppression. Read More

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http://dx.doi.org/10.1155/2019/1840280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800913PMC
October 2019

Granulomatous inflammation diagnosed by fine-needle aspiration biopsy.

J Am Soc Cytopathol 2019 Nov - Dec;8(6):317-323. Epub 2019 Aug 14.

Department of Pathology, University of California, San Francisco, California.

Introduction: Fine-needle aspiration biopsy (FNAB) is a minimally invasive biopsy technique and an important tool for diagnosing infectious diseases. Rapid onsite evaluation allows for triage for ancillary testing, including microbiologic cultures. We aimed to determine the etiology of granulomatous inflammation diagnosed by FNAB by correlating with culture results and clinical history. Read More

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http://dx.doi.org/10.1016/j.jasc.2019.07.004DOI Listing

Etiological Evaluation of Patients with Lymphadenopathy by Clinical, Histopathological and Microbiological Assessment.

Mymensingh Med J 2019 Oct;28(4):854-861

Dr Muhammad Jamal Uddin, EMO, 250 Bed District Sadar Hospital, Feni, Bangladesh; E-mail:

Lymph node enlargement is a common presenting complaint in outpatient and inpatient department. The present observational cross sectional study was conducted in department of Internal Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh during the period from December 2014 to May 2016 to evaluate etiologies of significant lymphadenopathy by clinical, histopathological and microbiological assessment. Biopsy/FNA materials of 177 patients of 18-75 years age range with significant lymphadenopathy were sent for histopathology/cytology, Gram stain & culture, AFB stain & culture and Gene Xpert. Read More

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October 2019
2 Reads

Aortic Graft Infection With Mycobacterium Avium Complex.

Vasc Endovascular Surg 2020 Feb 2;54(2):191-194. Epub 2019 Oct 2.

Department of Vascular Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Aortic graft infections are uncommon complications after endovascular aortic surgery. In the majority of cases, gram-positive and then gram-negative organisms are the causative agents leading to this condition. Atypical organisms are traditionally not responsible for graft infection unless the patient is immunocompromised. Read More

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http://dx.doi.org/10.1177/1538574419879570DOI Listing
February 2020
1 Read

Atypical Laryngeal Infections: Localized Lesions from Unusual Organisms May Simulate Malignancy.

Ann Otol Rhinol Laryngol 2020 Jan 14;129(1):82-86. Epub 2019 Sep 14.

Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, NorthShore University HealthSystem, Evanston, IL, USA.

Objective: The identification of rare sources of laryngeal infection in immunocompetent patients. Recovered organisms were (laryngeal tuberculosis [LTB]), (laryngeal [LMF]), and (laryngeal blastomycosis [LB]).

Method: Single institution retrospective case series of three patients over a 2. Read More

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http://dx.doi.org/10.1177/0003489419875755DOI Listing
January 2020
3 Reads

Sporotrichoid presentation of lupus vulgaris mimicking mycetoma.

Int J Mycobacteriol 2019 Jul-Sep;8(3):292-294

Department of Dermatology, AIIMS, Raipur, Chhattisgarh, India.

Most common form of cutaneous tuberculosis (TB) is lupus vulgaris (LV). Atypical presentation of LV is rare and may lead to delay in diagnosis and hence increase in morbidity. Here, we report a case of sporotrichoid form of LV in a 38 year old male who presented as cutaneous lesions mimicking mycetoma. Read More

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http://dx.doi.org/10.4103/ijmy.ijmy_113_19DOI Listing
January 2020
3 Reads

Suspected colonic cancer turns out to be disseminated tuberculosis in a kidney transplant recipient: A case report.

Medicine (Baltimore) 2019 Sep;98(36):e16995

Department of Nephrology and Hypertension.

Rationale: Active tuberculosis constitutes a relevant risk for kidney transplant recipients. In contrast to immunocompetent hosts, kidney transplant recipients often show atypical presentation and course of the disease impeding diagnosis. Especially extrapulmonary or disseminated infection is more frequent and can resemble malignant processes. Read More

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http://dx.doi.org/10.1097/MD.0000000000016995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738975PMC
September 2019
3 Reads

Role of percutaneous transpedicular biopsy in diagnosis of spinal tuberculosis and its correlation with the clinico-radiological features.

Indian J Tuberc 2019 Jul 8;66(3):388-393. Epub 2018 Jun 8.

Department of Orthopaedics, AIIMS, Great Eastern Road, Tatibandh, Raipur, Chhattisgarh 429099, India.

Introduction: Tuberculosis (TB) has long been an important cause of destructive lesions of spine in India. However the scenario is fast changing with atypical presentations and increasing reports of non-tubercular conditions. This poses a great diagnostic dilemma. Read More

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http://dx.doi.org/10.1016/j.ijtb.2018.05.019DOI Listing
July 2019
2 Reads

Role of line probe assay in detection of extra-pulmonary tuberculosis: Experience from a tertiary care hospital in western Maharashtra.

Indian J Tuberc 2019 Jul 11;66(3):325-330. Epub 2018 Jul 11.

Pathologist, Department of Pathology and Microbiology, Poona Hospital and Research Center, 27, Sadashiv Peth, Pune 30, India.

Background: Diagnosis of extra pulmonary tuberculosis (EPTB) is challenging due to its atypical clinical presentation and frequently results in a delay or deprivation of treatment. Apart from rapid case detection, early determination of MDR status is imperative in such situations. The commercially available Geno Type MTBDRplus assay version 2. Read More

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http://dx.doi.org/10.1016/j.ijtb.2018.06.011DOI Listing
July 2019
8 Reads

Protein Export into and across the Atypical Diderm Cell Envelope of Mycobacteria.

Microbiol Spectr 2019 07;7(4)

Department of Microbiology and Immunology, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599.

Mycobacteria, including the infamous pathogen , are high-GC Gram-positive bacteria with a distinctive cell envelope. Although there is a typical inner membrane, the mycobacterial cell envelope is unusual in having its peptidoglycan layer connected to a polymer of arabinogalactan, which in turn is covalently attached to long-chain mycolic acids that help form a highly impermeable mycobacterial outer membrane. This complex double-membrane, or diderm, cell envelope imparts mycobacteria with unique requirements for protein export into and across the cell envelope for secretion into the extracellular environment. Read More

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http://dx.doi.org/10.1128/microbiolspec.GPP3-0043-2018DOI Listing
July 2019
1 Read

Hodgkin Lymphoma, Tuberculosis, and Atypical Radiologic Image

Turk J Haematol 2019 Nov 7;36(4):301-302. Epub 2019 Aug 7.

Joseph Ayobabalola University, Ikeji-Arakeji, Nigeria

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http://dx.doi.org/10.4274/tjh.galenos.2019.2019.0291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863025PMC
November 2019
1 Read

Tuberculosis, onychomycosis and immune deficiency in complicated Crohn's disease.

BMJ Case Rep 2019 Aug 4;12(8). Epub 2019 Aug 4.

Department of Pediatrics, National Guard Health Affairs, Jeddah, Saudi Arabia.

The immune system is composed of innate humoral defence and adaptive immunity. One of the key mechanisms of the innate humoral defence is through complement activation. Mutations of certain enzyme may affect the complement activation and result in decreased defence against microorganisms. Read More

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http://dx.doi.org/10.1136/bcr-2018-228986DOI Listing
August 2019
3 Reads

Sonographic presentation of rice bodies in subacromial-subdeltoid chronic bursitis.

Ultrasound J 2019 Jul 22;11(1):16. Epub 2019 Jul 22.

Dean Faculty of Allied Health Sciences (FAHS), The University of Lahore, Lahore, Pakistan.

Background: subacromial-subdeltoid chronic bursitis is one of the main causes of shoulder pain syndrome. There are various causes of shoulder pain syndrome including chronic bursitis. The sonographic appearances of chronic bursitis vary from patient to patient, depending upon the underlying cause. Read More

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http://dx.doi.org/10.1186/s13089-019-0130-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643005PMC
July 2019
4 Reads

Non-tuberculous mycobacterial ocular infection masquerading as choroidal tumour - a diagnostic conundrum.

GMS Ophthalmol Cases 2019 5;9:Doc25. Epub 2019 Jul 5.

Department of Ophthalmology, Hospital Tuanku Ampuan Najihah Kuala Pilah, Malaysia.

To report a rare case of non-tuberculous mycobacterial (NTM) choroiditis masquerading as choroidal tumour, where the initial diagnosis was masked by keratitis. A 57-year-old heroin chaser with a pre-existing left eye blindness due to past blunt trauma presented with diffuse bacterial keratitis on the same side. Systemic examination revealed multiple non-tender cervical lymphadenopathies. Read More

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http://dx.doi.org/10.3205/oc000114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637434PMC
July 2019
2 Reads

Factors associated with atypical radiological findings of pulmonary tuberculosis.

PLoS One 2019 25;14(7):e0220346. Epub 2019 Jul 25.

Respiratory Medicine and Infectious Diseases, Oita University Faculty of Medicine, Idaigaoka, Hasama-machi, Yufu, Oita, Japan.

Background: Unusual radiological images may delay diagnosis of pulmonary tuberculosis. This study aimed to analyze the risk factors for an atypical radiological image in patients with pulmonary tuberculosis.

Methods: We retrospectively analyzed data from patients admitted to one hospital from January 2013 to December 2016 for sputum smear-positive lung tuberculosis who underwent chest computed tomography (CT) on admission. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0220346PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657914PMC
March 2020
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Post-surgical atypical mycobacteriosis in 125 patients in Rio de Janeiro.

Rev Soc Bras Med Trop 2019 Jul 18;52:e20190039. Epub 2019 Jul 18.

Disciplina de Doenças Infecciosas e Parasitárias, Faculdade de Medicina, Universidade Federal Fluminense, Niterói, RJ, Brasil.

Introduction: The growing incidence of post-surgical atypical mycobacteriosis (PSAM) may be related to the increased use of low- and medium-complexity video-assisted surgery.

Methods: Between April 2007 and June 2009, 125 patients were referred from the State Health Department of Rio de Janeiro for the treatment of confirmed, probable, or suspected PSAM.

Results: Laparoscopic cholecystectomy was the most frequent surgical procedure (48. Read More

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http://dx.doi.org/10.1590/0037-8682-0039-2019DOI Listing
July 2019
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Radiological features and progression of incipient active pulmonary tuberculosis according to risk factors.

Int J Tuberc Lung Dis 2019 06;23(6):698-706

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.

OBJECTIVES To examine the radiological features of incipient active pulmonary tuberculosis (PTB) in humans and evaluate radiological progression according to risk factors. DESIGN We retrospectively included 66 non-human immunodeficiency virus patients with bacteriologically proven PTB who had diagnostic and incidental pre-diagnostic computed tomography (CT) scans. CT scans were reviewed using a scoring system that included typical and atypical abnormalities associated with PTB. Read More

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http://dx.doi.org/10.5588/ijtld.18.0541DOI Listing

Mechanism of catalysis and inhibition of Mycobacterium tuberculosis SapM, implications for the development of novel antivirulence drugs.

Sci Rep 2019 07 16;9(1):10315. Epub 2019 Jul 16.

School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, M13 9PT, UK.

Mycobacterium tuberculosis (Mtb) SapM is a secreted virulence factor critical for intracellular survival of the pathogen. The role of SapM in phagosome maturation arrest in host macrophages suggests its potential as a drug target to assist in the clearance of tuberculosis infection. However, the mechanism of action of SapM at the molecular level remains unknown. Read More

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http://dx.doi.org/10.1038/s41598-019-46731-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635428PMC
July 2019
3 Reads

Atypical granuloma formation in Mycobacterium bovis-infected calves.

PLoS One 2019 15;14(7):e0218547. Epub 2019 Jul 15.

Laboratorio de Investigación en Tuberculosis Bovina, Departamento de Microbiología e Inmunología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Mexico City, Mexico.

Bovine tuberculosis is a chronic inflammatory disease that causes granuloma formation. Characterization of granulomatous lesions of Mycobacterium bovis (M. bovis) experimentally infected cattle has helped to better understand the pathogenesis of this disease. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0218547PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629060PMC
February 2020
2 Reads

[Cerebral tuberculoma a diagnostic challenge: case study and update].

Pan Afr Med J 2019 10;32:176. Epub 2019 Apr 10.

Service de Neurochirurgie, CHU Ibn Sina, Rabat, Maroc.

Central nervous system (CNS) tuberculosis is the second most common presentation after tuberculous meningitis. It is a major cause of morbidity and mortality in the developing countries, accounting for 10-30% of intracranial expansive lesions in these countries against 0.2% in some Western countries. Read More

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http://dx.doi.org/10.11604/pamj.2019.32.176.16623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607260PMC
July 2019
3 Reads

Etiology of Pulmonary Infections in Human Immunodeficiency Virus-infected Inpatients Using Sputum Multiplex Real-time Polymerase Chain Reaction.

Clin Infect Dis 2020 Mar;70(6):1147-1152

Division of Infectious Diseases and Human Immunodeficiency Virus Medicine, Department of Medicine, University of Cape Town, South Africa.

Background: There are limited data on the etiology of respiratory infections in human immunodeficiency virus (HIV)-infected patients in resource-limited settings.

Methods: We performed quantitative multiplex real-time polymerase chain reaction (PCR) for Pneumocystis jirovecii and common bacterial and viral respiratory pathogens on sputum samples (spontaneous or induced) from a prospective cohort study of HIV-infected inpatients with World Health Organization danger signs and cough. Mycobacterial culture was done on 2 sputum samples, blood cultures, and relevant extrapulmonary samples. Read More

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http://dx.doi.org/10.1093/cid/ciz332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108142PMC
March 2020
6 Reads

Chronic foot pain, an atypical tuberculosis presentation.

Med Mal Infect 2019 Sep 27;49(6):471-473. Epub 2019 Jun 27.

Service de pneumologie, hôpital Foch, Suresnes, 92150 France. Electronic address:

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http://dx.doi.org/10.1016/j.medmal.2019.05.003DOI Listing
September 2019
2 Reads