1,282 results match your criteria Atypical Mole Dysplastic Nevus

Is it necessary to perform eye examination for patients with cutaneous atypical nevi?

Dermatol Ther 2020 11 10;33(6):e14503. Epub 2020 Nov 10.

Private Practice, Izmir, Turkey.

Regular dermatological examination for patients with dysplastic nevi is indicated. However, the literature on whether those patients should also be examined by ophthalmologists or not regarding a relation between suspicious lesions for ocular melanoma and cutaneous dysplastic nevi is limited. In this study, we aimed to compare the findings of a single ophthalmologic examination between the group of patients with multiple atypical nevi with at least one histopathologically proven dysplastic nevus and another group without atypical nevi. Read More

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November 2020

RAF1 Gene Fusions as a Possible Driver Mechanism in Rare BAP1-Inactivated Melanocytic Tumors: A Report of 2 Cases.

Am J Dermatopathol 2020 Dec;42(12):961-966

Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Pilsen, Czech Republic.

BRCA1-associated protein (BAP1)-inactivated melanocytic tumor (BIMT) is a group of epithelioid melanocytic neoplasms characterized by the loss of function of BAP1, a tumor suppressor gene located on chromosome 3p21. They occur sporadically or in the setting of an autosomal-dominant cancer susceptibility syndrome that predisposes to the development of different internal malignancies. Most of these cutaneous lesions are associated with a BRAF-mutated melanocytic nevus and therefore are included in the group of combined nevi in the last WHO classification of skin tumors. Read More

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December 2020

Keratinocytic epidermal nevi associated with localized fibro-osseous lesions without hypophosphatemia.

Pediatr Dermatol 2020 Sep 14;37(5):890-895. Epub 2020 Jul 14.

Department of Dermatology, University Hospitals of Leuven, Leuven, Belgium.

Keratinocytic epidermal nevi (KEN) are characterized clinically by permanent hyperkeratosis in the distribution of Blaschko's lines and histologically by hyperplasia of epidermal keratinocytes. KEN with underlying RAS mutations have been associated with hypophosphatemic rickets and dysplastic bone lesions described as congenital cutaneous skeletal hypophosphatemia syndrome. Here, we describe two patients with keratinocytic epidermal nevi, in one associated with a papular nevus spilus, who presented with distinct localized congenital fibro-osseous lesions in the lower leg, diagnosed on both radiology and histology as osteofibrous dysplasia, in the absence of hypophosphatemia or rickets, or significantly raised FGF23 levels but with distinct mosaic HRAS mutations. Read More

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September 2020

Cluster of pregnancy-associated melanoma: A case report and brief update.

J Dermatol 2020 Sep 18;47(9):1054-1057. Epub 2020 Jun 18.

QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.

Melanoma incidence is increasing globally with Australia having the highest incidence in the world. Pregnancy-associated melanoma is recognized in the published work; however, significant knowledge deficiencies exist. We present the case of a 34-year-old woman with dysplastic nevus syndrome who over a 15-year period developed a total of nine melanomas, with eight clustered around an 18-month peri- to post-partum period. Read More

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September 2020

A retrospective cohort study of the diagnostic value of different subtypes of atypical pigment network on dermoscopy.

J Am Acad Dermatol 2020 Oct 21;83(4):1028-1034. Epub 2020 May 21.

Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; Robert H. Lurie Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. Electronic address:

Background: Atypical network encompasses several patterns. Few studies assess the sensitivity, specificity, and positive and negative predictive values of network subtypes.

Objective: We assessed the diagnostic value of atypical network subtypes and their histopathologic correlates in cutaneous melanocytic lesions. Read More

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October 2020

The role of reflectance confocal microscopy in differentiating melanoma in situ from dysplastic nevi with severe atypia: A cross-sectional study.

J Am Acad Dermatol 2020 Oct 19;83(4):1035-1043. Epub 2020 May 19.

The Kittner Skin Cancer Screening & Research Institute, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Melanoma in situ and dysplastic nevi with severe atypia present overlapping histopathologic features. Reflectance confocal microscopy findings can be integrated with the dermatopathology report to improve differentiation between melanoma and dysplastic nevi with severe atypia.

Objective: To compare prevalence of reflectance confocal microscopy findings between melanoma in situ and dysplastic nevi with severe atypia. Read More

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October 2020

The differential expression of micro-RNAs 21, 200c, 204, 205, and 211 in benign, dysplastic and malignant melanocytic lesions and critical evaluation of their role as diagnostic biomarkers.

Virchows Arch 2020 Jul 9;477(1):121-130. Epub 2020 May 9.

School of Medicine, University of St Andrews, St Andrews, UK.

Overlapping histological features between benign and malignant lesions and a lack of firm diagnostic criteria for malignancy result in high rates of inter-observer variation in the diagnosis of melanocytic lesions. We aimed to investigate the differential expression of five miRNAs (21, 200c, 204, 205, and 211) in benign naevi (n = 42), dysplastic naevi (n = 41), melanoma in situ (n = 42), and melanoma (n = 42) and evaluate their potential as diagnostic biomarkers of melanocytic lesions. Real-time PCR showed differential miRNA expression profiles between benign naevi; dysplastic naevi and melanoma in situ; and invasive melanoma. Read More

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Loss of Wild-Type CDKN2A Is an Early Event in the Development of Melanoma in FAMMM Syndrome.

J Invest Dermatol 2020 11 28;140(11):2298-2301.e3. Epub 2020 Mar 28.

Department of Dermatology, LUMC, Leiden, the Netherlands. Electronic address:

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November 2020

Neurofibromatosis type 1 and melanoma of the iris arising from a dysplastic nevus: A rare yet casual association?

Eur J Ophthalmol 2020 Feb 16:1120672120906999. Epub 2020 Feb 16.

Laboratorio di Genetica Medica, Dipartimento di Scienze Biomediche e Oncologia Umana, Università degli Studi di Bari Aldo Moro, Bari, Italy.

Purpose: We investigated the molecular causes of an unusual pigmented and ulcerated iris lesion detected in a patient diagnosed with neurofibromatosis type 1 (NF1).

Case Report: A 52-year-old man was referred to our clinic with a non-traumatic ulcer in his left eye. Hyphema reabsorption disclosed a pigmented iris mass, thus ultrasound biomicroscopy and anterior segment fluorescein angiography were performed to investigate for the presence of a malignant lesion. Read More

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February 2020

A novel surgical margin (1 cm) might be from benefit for patients with dysplastic nevi, thin melanomas, and melanoma in situ: Analysis based on clinical cases.

Dermatol Ther 2020 03 17;33(2):e13261. Epub 2020 Feb 17.

Department of Dermatology and Venereology, University of Rome "G. Marconi", Rome, Italy.

Malignant melanoma is an oncologic disease, whose current management among others includes surgical and immunological therapy. According to the current recommendations of the American Joint Committee on Cancer, the surgical excision of the primary tumor should be performed in two operative sessions, which has several consequences. The following paper will present and discuss six cases of pigmented lesions and the advantages of the one-step melanoma surgery in their management. Read More

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Development of esophageal squamous cell cancer in patients with FAMMM syndrome: Two clinical reports.

Eur J Med Genet 2020 Mar 7;63(3):103840. Epub 2020 Jan 7.

Department of Surgery, Erasmus MC - University Medical Center, Rotterdam, the Netherlands.

Familial atypical multiple mole melanoma (FAMMM) syndrome is a hereditary syndrome characterized by multiple dysplastic nevi and melanoma. Patients with FAMMM may have a heterozygous, inactivating, pathogenic germline variant in the CDKN2A gene, especially the NM_000077.4: c. Read More

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Malignant transformation of choroidal nevus according to race in 3334 consecutive patients.

Indian J Ophthalmol 2019 12;67(12):2035-2042

Department of Ophthalmology, Ocular Oncology Service, Wills Eye Hospital, Jefferson University, Philadelphia, PA, USA.

Purpose: To evaluate choroidal nevus demographics, clinical features, imaging features, and the rate of transformation into melanoma by race.

Methods: In This Observational Case Series,: There were 3334 participants (3806 choroidal nevi) at a single tertiary-referral center evaluated between January 2, 2007, and August 7, 2017. Retrospective chart and multimodal imaging review was performed. Read More

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December 2019

Descriptive study of naevus involution in a series of 74 patients with atypical naevus syndrome under SIAscopy digital follow-up.

J Eur Acad Dermatol Venereol 2020 Jun 6;34(6):1210-1217. Epub 2020 Feb 6.

Department of Dermatology, Hospital Universitari Arnau de Vilanova, University of Lleida, IRBLleida, Lleida, Spain.

Background: Characterization of nevi involution could help to understand the biological behaviour of melanocytic neoplasms.

Objective: To describe the frequency and morphology of naevus involution in a series of patients with atypical naevus syndrome under digital follow-up with a SIAscopy program and, in a small sample of fading nevi, to analyse histopathological features and immunohistochemical biomarkers.

Methods: Seventy-four patients registered from April 2007 to July 2014 in the SIAscopy system of the Department of Dermatology of Hospital Arnau de Vilanova of Lleida, Spain, were reviewed. Read More

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Information framing effects on patients' decisions about dysplastic nevus management.

J Am Acad Dermatol 2020 Apr 31;82(4):1011-1013. Epub 2019 Oct 31.

Department of Dermatology, Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania. Electronic address:

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Management of pigmented skin lesions during pregnancy.

Aust J Gen Pract 2019 09;48(9):621-624

​MD, Chairman, Australian Melanoma Clinical Practice Guidelines Working Party; Professor of Melanoma and Surgical Oncology, University of Sydney, Sydney, NSW; Surgeon, Royal Prince Alfred Hospital and Melanoma Institute Australia, Sydney, NSW.

Background: As a result of the rapidly changing hormonal milieu, changing or newly discovered pigmented skin lesions during pregnancy can be diagnostically challenging. It is important for GPs to be aware of the effect of gestational changes on pigment production and features that should raise concern.

Objective: The aim of this article is to provide an understanding of common changes that may occur in pigmented lesions during pregnancy, features that are of concern and the management of suspected melanoma in pregnant women. Read More

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September 2019

A case of malignant melanoma after repeated recurrent dysplastic nevi.

Arch Craniofac Surg 2019 Aug 20;20(4):260-264. Epub 2019 Aug 20.

Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.

Dysplastic nevus is common and affects about 10% of the northern European-descendent population. Studies over the past several decades have identified dysplastic nevi as a risk factor for malignant melanoma. Furthermore, in rare cases, they confirmed that dysplastic nevi have progressed to melanoma. Read More

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Negative predictive value of biopsy margins of dysplastic nevi: A single-institution retrospective review.

J Am Acad Dermatol 2020 Jan 19;82(1):87-93. Epub 2019 Jul 19.

Department of Dermatology, University of Alabama Birmingham, Birmingham, Alabama.

Background: Biopsies of dysplastic nevi processed by bread-loafing allow for limited margin assessment; however, reported biopsy margins often influence management.

Objective: To evaluate the negative predictive value of biopsy margins of dysplastic nevi.

Methods: A retrospective search of a single academic institution's pathology database was conducted to identify all biopsy specimens of dysplastic nevi between January 1, 2015, and December 31, 2017. Read More

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January 2020

Outcomes of surgical re-excision versus observation of severely dysplastic nevi: A single-institution, retrospective cohort study.

J Am Acad Dermatol 2020 01 17;82(1):238-240. Epub 2019 Jul 17.

Dermatology Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, California; Department of Dermatology, Pigmented Lesion and Melanoma Program, Stanford University Medical Center and Cancer Institute, Stanford, California. Electronic address:

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January 2020

Improvement of diagnostic confidence and management of equivocal skin lesions by integration of reflectance confocal microscopy in daily practice: Prospective study in 2 referral skin cancer centers.

J Am Acad Dermatol 2020 Oct 13;83(4):1057-1063. Epub 2019 Jun 13.

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Dermatology Department, Melanoma Unit, Hospital Clínic de Barcelona, Institut d'Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain; Centro de Investigación en Red en Enfermedades Raras (CIBERER) Instituto Carlos III, Barcelona, Spain. Electronic address:

Background: Reflectance confocal microscopy (RCM) allows accurate, noninvasive, in vivo diagnosis for skin cancer. However, its impact on physicians' diagnostic confidence and management is unknown.

Objectives: We sought to assess the physicians' diagnostic confidence and management before and after RCM of equivocal skin lesions. Read More

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October 2020

Skin Cancer: Precancers.

FP Essent 2019 Jun;481:23-27

Firelands Regional Medical Center Family Medicine Residency, 1111 Hayes Ave, Sandusky, OH 44870.

Actinic keratoses (AKs) are common skin lesions caused by cumulative sun exposure. Rates of lesion progression to squamous cell carcinoma (SCC) have been reported to be between 0.025% and 16%, some lesions may regress. Read More

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Eruptive Melanocytic Nevi: A Review.

Am J Clin Dermatol 2019 Oct;20(5):669-682

Department of Dermatology, Zealand University Hospital, Roskilde, Denmark.

Eruptive melanocytic nevi (EMN) is a phenomenon characterized by the sudden onset of nevi. Our objective was to compile all published reports of EMN to identify possible precipitating factors and to evaluate the clinical appearance and course. We conducted a systematic bibliographic search and selected 93 articles, representing 179 patients with EMN. Read More

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October 2019

Excision recommendation rates of atypical (dysplastic) nevi amongst experienced dermatopathologists.

J Cutan Pathol 2019 Oct 20;46(10):798-799. Epub 2019 Jun 20.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York.

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October 2019

Male CDPX2 patient with EBP mosaicism and asymmetrically lateralized skin lesions with strict midline demarcation.

Am J Med Genet A 2019 07 29;179(7):1315-1318. Epub 2019 Apr 29.

Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.

X-linked dominant chondrodysplasia punctata (Conradi-Hunermann-Happle syndrome, CDPX2) caused by mutations in the emopamil-binding protein (EBP) gene and congenital hemidysplasia with ichthyosiform nevus and limb defects (CHILD) syndrome caused by mutation in the NAD(P)H steroid dehydrogenase-like (NSDHL) gene are rare, typically male lethal disorders. CDPX2 skin lesions are characterized by transient severe congenital ichthyosis following the lines of Blaschko, whereas in CHILD syndrome, the lesions show striking lateralization. Here, we report a male CDPX2 patient with postzygotic mosaicism of the EBP gene presenting with lateralized skin lesions with strict midline demarcation as seen in CHILD syndrome (although this diagnosis was ruled out based on analysis of NSDHL), but also partly distributed along Blaschko's lines as seen in CDPX2. Read More

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Simultaneous long-lasting regression of multiple nevi and melanoma metastases after ipilimumab therapy.

Melanoma Res 2019 06;29(3):311-312

Department of Dermatology, Rouen University Hospital, Rouen.

We report a case of major regression of multiple atypical melanocytic nevi with a vitiligoid reaction in a patient with metastatic melanoma who achieved long-lasting complete remission after ipilimumab therapy. In 2008, a 54-year-old man presented with a dysplastic nevus syndrome. The patient was diagnosed with a scalp ulcerated melanoma (Breslow index 5. Read More

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Multiple primary melanoma with the Meyerson phenomenon in a young patient.

Melanoma Res 2019 06;29(3):325-327

Departments of Dermatology.

Meyerson phenomenon (MP), also called halo eczema or halo dermatitis, was first described in 1971 as a symmetric eczematous halo around acquired melanocytic nevi. Since then, cases of MP have been described in any kind of melanocytic nevi and also in non-melanocytic tumors. To the best of our knowledge, only four cases of melanoma associated with MP have been reported. Read More

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Analysis of the Gene in FAMMM Syndrome Families Reveals Early Age of Onset for Additional Syndromic Cancers.

Cancer Res 2019 06 9;79(11):2992-3000. Epub 2019 Apr 9.

Hereditary Cancer Center, Creighton University, Omaha, Nebraska.

Familial atypical multiple mole melanoma (FAMMM) syndrome is a hereditary cancer syndrome that results from mutations in several genes, including the gene. In addition to melanoma, certain other malignancies such as pancreatic cancer are known to occur more frequently in family members who carry the mutation. However, as these families have been followed over time, additional cancers have been observed in both carriers and noncarriers. Read More

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