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    1188 results match your criteria Atypical Mole Dysplastic Nevus

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    Combined in vivo reflectance confocal microscopy and digital dermoscopy for follow up of patients at high risk of malignant melanoma: A prospective case series study.
    J Dermatol 2017 Feb 13. Epub 2017 Feb 13.
    Department of Dermatology, University Hospital Fundación Alcorcón, Rey Juan Carlos University, Madrid, Spain.
    Digital dermoscopy (DD) follow up is a useful strategy for monitoring patients at high risk of melanoma. Reflectance confocal microscopy (RCM) is a valuable second-level examination after dermoscopy for the evaluation of difficult to diagnose lesions. The aim of this study was to assess the value of RCM in routine DD monitoring of patients at high risk of melanoma. Read More

    Genomic Characterization of Dysplastic Nevi Unveils Implications for Diagnosis of Melanoma.
    J Invest Dermatol 2016 Nov 24. Epub 2016 Nov 24.
    Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, New York, USA. Electronic address:
    A well-defined risk factor and precursor for cutaneous melanoma is the dysplastic nevus. These benign tumors represent clonal hyperproliferation of melanocytes that are in a senescent-like state, but with occasional malignant transformation events. To portray the mutational repertoire of dysplastic nevi in patients with the dysplastic nevus syndrome and to determine the discriminatory profiles of melanocytic nevi (including dysplastic nevi) from melanoma, we sequenced exomes of melanocytic nevi including dysplastic nevi (n = 19), followed by a targeted gene panel (785 genes) characterization of melanocytic nevi (n = 46) and primary melanomas (n = 42). Read More

    "Melanoma: Questions and Answers." Development and evaluation of a psycho-educational resource for people with a history of melanoma.
    Support Care Cancer 2016 Dec 27;24(12):4849-4859. Epub 2016 Jul 27.
    Centre for Cancer Research, The University of Sydney at The Westmead Institute for Medical Research and Melanoma Institute Australia, Sydney, NSW, 2145, Australia.
    Purpose: People with melanoma often report pervasive fears about cancer recurrence, unmet information needs, and difficulties accessing psychological care. Interventions addressing the supportive care needs of people with melanoma are rare, and needs are often overlooked. The study evaluated a newly developed, evidence-based, psycho-educational resource for people with melanoma. Read More

    Reexcision Perineural Invasion and Epithelial Sheath Neuroma Possibly on a Spectrum of Postinjury Reactive Hyperplasia Mediated by IL-6.
    Am J Dermatopathol 2017 Jan;39(1):49-52
    *Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY; †Ohio State University Comprehensive Cancer Center, Columbus, OH; and ‡NYC Dermatology and Cosmetic Center, New York, NY.
    Epithelial sheath neuroma is a rarely recognized but established entity in the medical literature. First described in 2000 by Requena et al, there have only been 7 published cases to date, mostly in female patients and presenting as symptomatic solitary lesions on the back without a known history of trauma. In 2006, Beer et al described and reviewed a dozen cases in which epithelial sheath neuroma-like features were seen in the advent of a surgical procedure, which was termed "re-excision perineural invasion" and attributed to possible eccrine duct implantation during surgery. Read More

    Association of vascular endothelial growth factor expression with patohistological parameters of cutaneous melanoma.
    Vojnosanit Pregl 2016 May;73(5):449-57
    Background/aim: Melanoma is the most aggresive malignant tumor of the skin. Contradictory data was published on vascular endothelial growth factor (VGEF) in tumor samples and its role in skin melanoma progression and prognosis. The aim of this study was to investigate the significance of VEGF expression as a prognostic parameter in melanoma. Read More

    Roum Arch Microbiol Immunol 2015 Jul-Dec;74(3-4):105-11
    Unlabelled: The authors' interest was focused on prolactin status in patients with melanocytic lesions and on changes induced by interferon treatment in melanoma patients.

    Material And Method: The study lasted 5 years and included 128 melanoma patients, 48 dysplastic nevi patients and 48 healthy volunteers. Sixty melanoma cases were selected after surgical removal of tumor and divided into 2 groups: 30 patients with 10 MUmp(-1) interferon alpha2b treatment, three times a week, one year and 30 patients without interferon treatment. Read More

    Cutaneous manifestations of genitourinary malignancy.
    Semin Oncol 2016 Jun 23;43(3):347-52. Epub 2016 Feb 23.
    Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC. Electronic address:
    Genitourinary cancers are associated with a range of cutaneous syndromes, which can reflect direct metastatic spread, non-metastatic manifestations of malignancy or the consequences of treatment. More than 220,000 new cases of prostate cancer occur each year in the United States, and thus the associations with cutaneous involvement are quite well documented-rare metastatic spread, vasculitic and hemorrhagic syndromes. Cancers of the bladder and kidney may be associated with direct cutaneous metastases, vasculitic syndromes, hereditary leiomyomatosis, and other familial syndromes. Read More

    Knowledge about Ultraviolet Radiation Hazards and Tanning Behavior of Cosmetology and Medical Students.
    Acta Dermatovenerol Croat 2016 Apr;24(1):73-7
    Ewelina Bogumiła Zuba, MD, Medical University of Poznan, 49 Przybyszewskiego St, 60-355 Poznan, Poland;
    Dear Editor, Ultraviolet (UV) radiation is a well-known physical hazard responsible for photoaging, photoallergic, and phototoxic reactions as well as carcinogenesis, including life-threatening melanomas (1,2). Overexposure to both natural and artificial UV radiation is a public health concern. 30% of cancers diagnosed worldwide are skin cancers. Read More

    Georgian Med News 2016 Feb(251):58-64
    1Department "Medicinal Information and Non-interventional studies", Bulgarian Drug Agency, Sofia, Bulgaria; 2"Onkoderma"- Ambulatory Clinic for Dermatology and Skin Surgery, Sofia, Bulgaria; 3Department of General and Clinical Pathology, Medical Faculty, "Saint Kliment Ohridski University"; 4Dermatology Department, University Hospital of Coimbra, Praceta Mota Pinto, Portugal; 5Department of General and Clinical pathology, Medical University of Plovdiv, Bulgaria; 6Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Germany.
    We describe a rare case of a 28 year-old male patient presenting with pruritus and increased sensitivity of the prepuce accompanied by erythematous confluent papules, unilateral nevus flammeus (NF) along almost the whole length of the right lower limb and two dysplastic nevi (DN), one located on the mid back and the other on the medial border of the right fifth toe, the latter coinciding with the NF. A biopsy of the prepuce revealed lichen sclerosus et atrophicus (LSA). Mental health assessment revealed anxiety disorder and predisposition to panic attacks. Read More

    A nongrading histologic approach to Clark (dysplastic) nevi: A potential to decrease the excision rate.
    J Am Acad Dermatol 2016 Jan 6;74(1):68-74. Epub 2015 Nov 6.
    Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania. Electronic address:
    Background: Despite a lack of evidence that dysplastic nevi are precursors to melanoma, a large proportion of dermatologists continue to treat them as such. Emerging data suggest that histologic grading approach may result in many unnecessary excisions.

    Objective: Using a nongrading approach to diagnosis of Clark/dysplastic nevi, the current study sought to define and determine the diagnostic uncertainty rate, and to report on the results of re-excisions of such lesions. Read More

    J Biol Regul Homeost Agents 2015 Jul-Sep;29(3):695-9
    “Onkoderma” –Policlinic for Dermatology, Venereology and Dermatologic Surgery, Sofia, Bulgaria.
    IMP-3 is generally considered as an oncofetal protein, which plays a critical role in regulation of cell proliferation via an IGF-II-dependent pathway in K562 leukemia cells. IMP-3 expression has been detected in malignancies with various origins, while its appearance in adult tissue is generally considered abnormal, with some exceptions. IMP3 is also considered a prognostic biomarker in patients with renal cell carcinoma and clear-cell type ovarian carcinoma, hepatocellular carcinoma, pancreatic ductal adenocarcinoma and in patients with poorly differentiated thyroid carcinoma and uterine cervical carcinomas, testicular cancer and malignant melanoma. Read More

    Immunosuppression is an independent prognostic factor associated with aggressive tumor behavior in cutaneous melanoma.
    J Am Acad Dermatol 2015 Sep 21;73(3):461-6. Epub 2015 Jul 21.
    Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; Robert H. Lurie Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. Electronic address:
    Background: A number of factors other than those identified by the American Joint Committee on Cancer (AJCC) may have prognostic significance in the evaluation of melanoma.

    Objective: We sought to evaluate commonly recorded clinical features potentially associated with aggressive melanoma.

    Methods: We conducted a retrospective case-control study. Read More

    Multiple Cutaneous Melanomas and Clinically Atypical Moles in a Patient With a Novel Germline BAP1 Mutation.
    JAMA Dermatol 2015 Nov;151(11):1235-9
    Wellman Center for Photomedicine and Department of Dermatology, Massachusetts General Hospital, Harvard University, Boston4Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston.
    Importance: Several kindreds having germline BAP1 mutations with a propensity for uveal and cutaneous melanomas and other internal malignancies have been described in an autosomal dominant tumor predisposition syndrome. However, clinically atypical moles have not been previously recognized as a component of this syndrome, to our knowledge. We describe the first kindred to date with a germline mutation in BAP1 associated with multiple cutaneous melanomas and classic dysplastic nevus syndrome. Read More

    Teledermatology-directed surgical care is safe and reduces travel.
    J Telemed Telecare 2016 Mar 26;22(2):121-6. Epub 2015 Jun 26.
    VA Puget Sound Health Care System, Seattle Division, USA University of Washington, Department of Medicine (Dermatology), Seattle, USA
    Methods: We conducted a retrospective chart review and identified 186 Veterans in the VA Corporate Data Warehouse as having malignant melanomas or severely dysplastic nevi during the four-year period of observation from 1 July 2009 to 30 June 2013 and met inclusion and exclusion criteria for analysis.

    Results: Three hundred and sixty-six surgical procedures were performed for diagnosis and treatment of these conditions including biopsy and wide-local excision, of which 189 carefully selected cases were performed by primary care clinicians with 2.0% biopsy complication rate and a 7. Read More

    Pancreatic cancer-associated gene polymorphisms in a nation-wide cohort of p16-Leiden germline mutation carriers; a case-control study.
    BMC Res Notes 2015 Jun 26;8:264. Epub 2015 Jun 26.
    Department of Clinical Genetics, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.
    Background: The p16-Leiden founder mutation in the CDKN2A gene is the most common cause of Familial Atypical Multiple Mole Melanoma (FAMMM) syndrome in the Netherlands. Individuals with this mutation are at increased risk for developing melanoma of the skin, as well as pancreatic cancer. However, there is a notable interfamilial variability in the occurrence of pancreatic cancer among p16-Leiden families. Read More

    Dysplastic nevus: Fact and fiction.
    J Am Acad Dermatol 2015 Sep 30;73(3):507-12. Epub 2015 May 30.
    Department of Dermatology, University of Connecticut Health Center, Farmington, Connecticut. Electronic address:
    The term "dysplastic nevus" (DN) implies that this nevus exists as a distinct and defined entity of potential detriment to its host. We examine the current data, which suggest that this entity exists as histologically and possibly genetically different from common nevus, with some overlapping features. Studies show that a melanoma associated with a nevus is just as likely to arise in a common nevus as in DN. Read More

    Practical application of new technologies for melanoma diagnosis: Part II. Molecular approaches.
    J Am Acad Dermatol 2015 Jun;72(6):943-58; quiz 959-60
    Department of Dermatology, University of Utah Health Sciences Center, Salt Lake City, Utah; Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah. Electronic address:
    The criterion standard for diagnosing cutaneous melanoma continues to be histologic examination. However, classifying some melanocytic lesions by conventional microscopy can be problematic if they exhibit some architectural or morphologic characteristics of both nevus and melanoma. Moreover, histologic appearance does not always predict biologic behavior. Read More

    Dysplastic Nevus: Management by Canadian Dermatologists.
    J Cutan Med Surg 2015 Sep-Oct;19(5):457-63. Epub 2015 Apr 1.
    Division of Dermatology, Toronto Western Hospital, Toronto, Canada Lynde Center for Dermatology, Markham, Canada.
    Background: The management of dysplastic nevi is controversial. No studies have collected data regarding management of the lesion amongst Canadian dermatologists.

    Objective: To provide a comprehensive review of what the prevailing opinions are, regarding treatment and terminology of dysplastic nevi, amongst Canadian dermatologists. Read More

    Automatic differentiation of melanoma from dysplastic nevi.
    Comput Med Imaging Graph 2015 Jul 7;43:44-52. Epub 2015 Mar 7.
    Le2i-UMR CNRS 6306, Université de Bourgogne, BP 47870, 21078 Dijon, France.
    Malignant melanoma causes the majority of deaths related to skin cancer. Nevertheless, it is the most treatable one, depending on its early diagnosis. The early prognosis is a challenging task for both clinicians and dermatologist, due to the characteristic similarities of melanoma with other skin lesions such as dysplastic nevi. Read More

    Melanocytic naevi clustered on normal background skin.
    Clin Exp Dermatol 2015 Apr 22;40(3):231-7. Epub 2015 Feb 22.
    Department of Dermatology, Queen Elizabeth Hospital, King's Lynn, UK.
    Several types of maculopapular melanocytic naevi can occur in a multiple form, and be arranged in a nonrandom fashion on the skin. The most frequently reported segmentally grouped naevi are lentigines. Two types of segmentally arranged lentigines probably exist. Read More

    BRAF wild-type melanoma in situ arising in a BRAF V600E mutant dysplastic nevus.
    JAMA Dermatol 2015 Apr;151(4):417-21
    Dermatology Research Centre, The University of Queensland, School of Medicine, Translational Research Institute, Brisbane, Australia.
    Importance: The BRAF V600E mutation accounts for the majority of BRAF mutations found in cutaneous melanoma and is also commonly found in nevi. We used dermoscopy-targeted sampling and a microbiopsy device coupled with DNA sequence analysis to highlight BRAF V600E heterogeneity within a multicomponent melanocytic proliferation. This sampling technique demonstrates the prospect of in vivo application in a clinical setting. Read More

    [Dysplastic melanocytic nevus].
    Pathologe 2015 Feb;36(1):46-50, 52
    Heinz-Werner-Seifert-Institut für Dermatopathologie Bonn, Trierer-Str. 70-72, 53115, Bonn, Deutschland,
    Dysplastic nevus is still a controversial entity both clinically and histologically. The occurrence of dysplastic nevus especially in the context of dysplastic nevus cell syndrome is associated with an increased risk for melanoma. The following minimal histological criteria should be fulfilled: nests of melanocytes varying in size and shape, bridging and confluent, proliferation of single melanocytes basal and suprabasal, cytoplasmic and nuclear atypia of melanocytes and subepidermal fibroplasia. Read More

    Diameter of dysplastic nevi is a more robust biomarker of increased melanoma risk than degree of histologic dysplasia: a case-control study.
    J Am Acad Dermatol 2014 Dec 15;71(6):1257-1258.e4. Epub 2014 Nov 15.
    Dermatoepidemiology Unit, VA Medical Center, Providence, Rhode Island; Department of Dermatology, Alpert Medical School, Brown University, Providence, Rhode Island; Department of Dermatology, Rhode Island Hospital, Providence, Rhode Island; Department of Epidemiology, Brown University, Providence, Rhode Island.

    Dysplastic nevi, cutaneous melanoma, and other skin neoplasms in patients with myotonic dystrophy type 1: a cross-sectional study.
    J Am Acad Dermatol 2015 Jan 5;72(1):85-91. Epub 2014 Nov 5.
    Department of Dermatology, University of Parma, Parma, Italy.
    Background: Myotonic dystrophy type 1 (MD1) is reported to be associated with internal malignancies. The association of myotonic dystrophy with cutaneous tumors is not fully understood.

    Objective: We sought to explore the total nevi count and the presence of atypical nevi, cutaneous melanoma, and other skin neoplasms in a representative cohort of patients with MD1 and to compare the findings with age- and sex-matched control subjects. Read More

    Addressing the knowledge gap in clinical recommendations for management and complete excision of clinically atypical nevi/dysplastic nevi: Pigmented Lesion Subcommittee consensus statement.
    JAMA Dermatol 2015 Feb;151(2):212-8
    Melanoma and Pigmented Lesion Clinic, Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia15Division of Dermatology, Atlanta Veterans Administration Medical Center, Decatur, Georgia.
    Importance: The management of clinically atypical nevi/dysplastic nevi (CAN/DN) is controversial, with few data to guide the process. Management recommendations for DN with positive histologic margins were developed by the Delphi method to achieve consensus among members of the Pigmented Lesion Subcommittee (PLS) of the Melanoma Prevention Working Group (MPWG) after reviewing the current evidence.

    Objectives: To outline key issues related to the management of CAN/DN: (1) biopsies of CAN and how positive margins arise, (2) whether incompletely excised DN evolve into melanoma, (3) current data on the outcomes of DN with positive histologic margins, (4) consensus recommendations, and (5) a proposal for future studies, including a large-scale study to help guide the management of DN with positive margins. Read More

    Characterization, treatment, and outcome of uveal melanoma in the first two years of life.
    Hematol Oncol Stem Cell Ther 2015 Mar 6;8(1):1-5. Epub 2014 Oct 6.
    Department of Surgery/Ophthalmology, King Hussein Cancer Centre, Amman, Jordan.
    Background And Objectives: Features and characteristics of uveal melanoma are well described in adults, but little is known about the presentation of uveal melanoma in infancy.

    Design: Systematic literature review.

    Methods: A review of published, peer-reviewed literature reporting on uveal melanoma presenting during the first two years of life. Read More

    The utility of re-excising mildly and moderately dysplastic nevi: a retrospective analysis.
    J Am Acad Dermatol 2014 Dec 26;71(6):1071-6. Epub 2014 Sep 26.
    Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:
    Background: The management of dysplastic nevi (DN) is a highly debated and controversial topic within the dermatology community. Clinicians agree that margin-positive severely DN should be removed with a surgical margin, however, there is disagreement surrounding the appropriate management of margin-positive mildly and moderately DN.

    Objective: We sought to evaluate the utility of re-excising margin-positive mildly and moderately DN. Read More

    Biopsy diagnoses of clinically atypical pigmented lesions of the head and neck in adults.
    Am J Dermatopathol 2014 Oct;36(10):829-31
    *New York Institute of Technology, College of Osteopathic Medicine, New York, NY; and †Ackerman Academy of Dermatopathology, New York, NY.
    A subset of facial melanoma in situ has histological features that overlap with those of "dysplastic" nevi. The authors evaluated this important diagnostic pitfall by assessing the frequency of melanoma as the final diagnosis in skin biopsies submitted over a 1-year period with a clinical impression of "atypical" or dysplastic nevus from the head or neck of adults. A total of 1998 biopsies met inclusion criteria. Read More

    Epidermal nevus syndrome and dysplatic kidney disease.
    Acta Med Iran 2014 ;52(8):647-9
    Department of Pathology, Razi Dermatology Hospital, Tehran University of Medical Sciences, Tehran, Iran.
    Epidermal nevus syndrome is a rare congenital disorder, characterized by epidermal nevi and multiple organ involvement. Multicystic kidney disease has been very rarely reported in this syndrome. Here is the report of a boy presented with multiple epidermal nevi, cardiac anomaly, seizure attack, hemi hypertrophy, and multicystic dysplastic kidney complicated with Wilms' tumor. Read More

    α-Methylacyl-coenzyme A racemase (AMACR, p504s) is a marker to distinguish malignant melanomas from dysplastic nevi and melanocytic nevi.
    Tumour Biol 2014 Dec 24;35(12):12015-20. Epub 2014 Aug 24.
    Institute of Pathology, Hannover medical School (MHH), Carl-Neuberg-Str. 1, 30625, Hannover, Germany,
    Routinely processed skin biopsies are still the mainstay for the diagnosis of melanocytic skin neoplasms (MSNs) and are considered the "gold standard" for individual patient management and clinical trials. The diagnostic challenge of melanocytic lesions of the skin prompts histopathologists to consider new diagnostic tools; among these, immunohistochemistry. We aimed to find putative new immunohistochemical markers, which can supplement the histological criteria used to detect dysplasia. Read More

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