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    1203 results match your criteria Atypical Mole Dysplastic Nevus

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    Melanomas and Dysplastic Nevi Differ in Epidermal CD1c+ Dendritic Cell Count.
    Biomed Res Int 2017 26;2017:6803756. Epub 2017 Feb 26.
    Chair of Pathomorphology, Faculty of Medicine, Jagiellonian University Medical College, Grzegórzecka 16, 31-351 Kraków, Poland.
    Background. Dendritic cells could be involved in immune surveillance of highly immunogenic tumors such as melanoma. Their role in the progression melanocytic nevi to melanoma is however a matter of controversy. Read More

    Combined in vivo reflectance confocal microscopy and digital dermoscopy for follow up of patients at high risk of malignant melanoma: A prospective case series study.
    J Dermatol 2017 Jun 13;44(6):681-689. Epub 2017 Feb 13.
    Department of Dermatology, University Hospital Fundación Alcorcón, Rey Juan Carlos University, Madrid, Spain.
    Digital dermoscopy (DD) follow up is a useful strategy for monitoring patients at high risk of melanoma. Reflectance confocal microscopy (RCM) is a valuable second-level examination after dermoscopy for the evaluation of difficult to diagnose lesions. The aim of this study was to assess the value of RCM in routine DD monitoring of patients at high risk of melanoma. Read More

    Genomic Characterization of Dysplastic Nevi Unveils Implications for Diagnosis of Melanoma.
    J Invest Dermatol 2017 Apr 24;137(4):905-909. Epub 2016 Nov 24.
    Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, New York, USA. Electronic address:
    A well-defined risk factor and precursor for cutaneous melanoma is the dysplastic nevus. These benign tumors represent clonal hyperproliferation of melanocytes that are in a senescent-like state, but with occasional malignant transformation events. To portray the mutational repertoire of dysplastic nevi in patients with the dysplastic nevus syndrome and to determine the discriminatory profiles of melanocytic nevi (including dysplastic nevi) from melanoma, we sequenced exomes of melanocytic nevi including dysplastic nevi (n = 19), followed by a targeted gene panel (785 genes) characterization of melanocytic nevi (n = 46) and primary melanomas (n = 42). Read More

    Dysplastic nevi with severe atypia: Long-term outcomes in patients with and without re-excision.
    J Am Acad Dermatol 2017 Feb 9;76(2):244-249. Epub 2016 Nov 9.
    Department of Dermatology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Electronic address:
    Background: Dysplastic nevi with severe atypia (severely dysplastic nevi [SDN]) are frequently re-excised because of the concern that these lesions may in fact represent early melanoma. Data on long-term follow-up of these patients are limited.

    Objective: We sought to determine the rate of subsequent melanoma development in patients with SDN who underwent re-excision versus those who did not and to determine factors associated with decision to re-excise. Read More

    "Melanoma: Questions and Answers." Development and evaluation of a psycho-educational resource for people with a history of melanoma.
    Support Care Cancer 2016 Dec 27;24(12):4849-4859. Epub 2016 Jul 27.
    Centre for Cancer Research, The University of Sydney at The Westmead Institute for Medical Research and Melanoma Institute Australia, Sydney, NSW, 2145, Australia.
    Purpose: People with melanoma often report pervasive fears about cancer recurrence, unmet information needs, and difficulties accessing psychological care. Interventions addressing the supportive care needs of people with melanoma are rare, and needs are often overlooked. The study evaluated a newly developed, evidence-based, psycho-educational resource for people with melanoma. Read More

    Reexcision Perineural Invasion and Epithelial Sheath Neuroma Possibly on a Spectrum of Postinjury Reactive Hyperplasia Mediated by IL-6.
    Am J Dermatopathol 2017 Jan;39(1):49-52
    *Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY; †Ohio State University Comprehensive Cancer Center, Columbus, OH; and ‡NYC Dermatology and Cosmetic Center, New York, NY.
    Epithelial sheath neuroma is a rarely recognized but established entity in the medical literature. First described in 2000 by Requena et al, there have only been 7 published cases to date, mostly in female patients and presenting as symptomatic solitary lesions on the back without a known history of trauma. In 2006, Beer et al described and reviewed a dozen cases in which epithelial sheath neuroma-like features were seen in the advent of a surgical procedure, which was termed "re-excision perineural invasion" and attributed to possible eccrine duct implantation during surgery. Read More

    Compliance with serial dermoscopic monitoring: An academic perspective.
    J Am Acad Dermatol 2016 Dec 21;75(6):1171-1175. Epub 2016 Sep 21.
    Department of Dermatology, Henry Ford Hospital, Detroit, Michigan. Electronic address:
    Background: For even seasoned practitioners, early melanomas can be difficult to distinguish from melanocytic nevi. Although serial digital dermoscopy is considered by many to be the gold standard for monitoring patients at high risk, poor compliance can seriously alter efficacy. In 2014, a concerning compliance rate of 25% was reported from a single, private clinic. Read More

    Commentary on Almassalha et al., "The Greater Genomic Landscape: The Heterogeneous Evolution of Cancer".
    Cancer Res 2016 10 16;76(19):5602-5604. Epub 2016 Sep 16.
    Department of Dermatology, Keck USC School of Medicine and the Hoag-USC Advanced Skin Cancer Program, Los Angeles, California.
    In this issue of Cancer Research, Almassalha and colleagues have proposed a new concept of the development of malignancy, that of the greater genomic landscape. They propose a stressor-related exploration of intracellular genomic sites as a response mechanism. This process can express sites with beneficial or deleterious effects, among them those that promote cell proliferation. Read More

    Reexamining the Threshold for Reexcision of Histologically Transected Dysplastic Nevi.
    JAMA Dermatol 2016 Dec;152(12):1327-1334
    Dermatology Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, California2Pigmented Lesion and Melanoma Program, Department of Dermatology, Stanford University Medical Center and Cancer Institute, Stanford, California.
    Importance: Controversy persists regarding the appropriate management of incompletely excised, biopsy-proven, mild and moderate dysplastic nevi (DN).

    Objective: To determine long-term risk of associated melanoma in biopsied mild or moderate DN with positive histologic margins that were clinically observed vs reexcised with negative margins.

    Design, Setting, And Participants: Retrospective cohort study of mixed referral and community patients from an academic pigmented lesion clinic and dermatology clinics of the affiliated Veteran Affairs medical center with biopsy-confirmed DN with positive histologic margins diagnosed from May 15, 1991, to July 8, 2015, and followed up through May 30, 2016. Read More

    Risk Factors and Relationship of Cutaneous and Uveal Melanocytic Lesions in Monozygotic and Dizygotic Twin Pairs.
    PLoS One 2016 3;11(8):e0160146. Epub 2016 Aug 3.
    Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary.
    Background: The similar genetic background of a pair of twins, and the similar environmental impacts to which they are exposed allow an exact and objective investigation of various constitutional and environmental factors in naevus development. As far as we are aware, this is the first published survey that simultaneously examines cutaneous and ocular pigmented lesions in an appreciable sample of identical and non-identical twins.

    Methods: 172 pairs of twins of Caucasian origin were included in this study. Read More

    5-Hydroxymethylcytosine Expression in Proliferative Nodules Arising within Congenital Nevi Allows Differentiation from Malignant Melanoma.
    J Invest Dermatol 2016 Dec 22;136(12):2453-2461. Epub 2016 Jul 22.
    Department of Dermatology and Venereology, University Hospital Centre (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland. Electronic address:
    Differentiation of proliferative nodules in giant congenital nevi from melanoma arising within such nevi is an important diagnostic challenge. DNA methylation is a well-established epigenetic modification already observed in the earliest stages of carcinogenesis, which increases during melanoma progression. The ten-eleven translocation enzymes catalyze the oxidation of 5-methylcytosine to 5-hydroxymethylcytosine (5-hmC), which has recently been reported as an epigenetic hallmark associated with tumor aggressiveness and poor prognosis in a wide variety of cancers. Read More

    Association of vascular endothelial growth factor expression with patohistological parameters of cutaneous melanoma.
    Vojnosanit Pregl 2016 May;73(5):449-57
    Background/aim: Melanoma is the most aggresive malignant tumor of the skin. Contradictory data was published on vascular endothelial growth factor (VGEF) in tumor samples and its role in skin melanoma progression and prognosis. The aim of this study was to investigate the significance of VEGF expression as a prognostic parameter in melanoma. Read More

    Discrimination of Dysplastic Nevi from Common Melanocytic Nevi by Cellular and Molecular Criteria.
    J Invest Dermatol 2016 Oct 1;136(10):2030-2040. Epub 2016 Jul 1.
    Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, USA. Electronic address:
    Dysplastic nevi (DNs), also known as Clark's nevi or atypical moles, are distinguished from common melanocytic nevi by variegation in pigmentation and clinical appearance, as well as differences in tissue patterning. However, cellular and molecular differences between DNs and common melanocytic nevi are not completely understood. Using cDNA microarray, quantitative RT-PCR, and immunohistochemistry, we molecularly characterized DNs and analyzed the difference between DNs and common melanocytic nevi. Read More

    SERUM PROLACTIN IN MELANOMA PATIENTS WITH INTERFERON ALPHA2B TREATMENT.
    Roum Arch Microbiol Immunol 2015 Jul-Dec;74(3-4):105-11
    Unlabelled: The authors' interest was focused on prolactin status in patients with melanocytic lesions and on changes induced by interferon treatment in melanoma patients.

    Material And Method: The study lasted 5 years and included 128 melanoma patients, 48 dysplastic nevi patients and 48 healthy volunteers. Sixty melanoma cases were selected after surgical removal of tumor and divided into 2 groups: 30 patients with 10 MUmp(-1) interferon alpha2b treatment, three times a week, one year and 30 patients without interferon treatment. Read More

    Nonoverlapping Clinical and Mutational Patterns in Melanomas from the Female Genital Tract and Atypical Genital Nevi.
    J Invest Dermatol 2016 Sep 21;136(9):1858-1865. Epub 2016 May 21.
    Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
    Genital melanomas (GM) are the second most common cancer of the female external genitalia and may be confused with atypical genital nevi (AGN), which exhibit atypical histological features but have benign behavior. In this study, we compared the clinical, histological, and molecular features of 19 GM and 25 AGN. We described chromosomal copy number aberrations and the mutational status of 50 oncogenes and tumor suppressor genes in both groups. Read More

    Cutaneous manifestations of genitourinary malignancy.
    Semin Oncol 2016 Jun 23;43(3):347-52. Epub 2016 Feb 23.
    Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC. Electronic address:
    Genitourinary cancers are associated with a range of cutaneous syndromes, which can reflect direct metastatic spread, non-metastatic manifestations of malignancy or the consequences of treatment. More than 220,000 new cases of prostate cancer occur each year in the United States, and thus the associations with cutaneous involvement are quite well documented-rare metastatic spread, vasculitic and hemorrhagic syndromes. Cancers of the bladder and kidney may be associated with direct cutaneous metastases, vasculitic syndromes, hereditary leiomyomatosis, and other familial syndromes. Read More

    Knowledge about Ultraviolet Radiation Hazards and Tanning Behavior of Cosmetology and Medical Students.
    Acta Dermatovenerol Croat 2016 Apr;24(1):73-7
    Ewelina Bogumiła Zuba, MD, Medical University of Poznan, 49 Przybyszewskiego St, 60-355 Poznan, Poland;
    Dear Editor, Ultraviolet (UV) radiation is a well-known physical hazard responsible for photoaging, photoallergic, and phototoxic reactions as well as carcinogenesis, including life-threatening melanomas (1,2). Overexposure to both natural and artificial UV radiation is a public health concern. 30% of cancers diagnosed worldwide are skin cancers. Read More

    Melanoma progression.
    Pathology 2016 Feb 16;48(2):147-54. Epub 2016 Jan 16.
    Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, United States. Electronic address:
    Tumours progress to fully malignant neoplasms through stages of development in a stepwise process. A carcinogenic stimulus such as UV light typically results in a large number of lesions, most of which are benign. Most such lesions will remain stable or regress, while a few will develop cytological and architectural atypia, placing them in a morphologically 'intermediate' category between wholly benign and fully malignant. Read More

    NEVUS FLAMMEUS ASSOCIATED WITH DYSPLASTIC NEVI AND LICHEN SCLEROSUS: THE FIRST REPORT IN THE MEDICAL LITERATURE.
    Georgian Med News 2016 Feb(251):58-64
    1Department "Medicinal Information and Non-interventional studies", Bulgarian Drug Agency, Sofia, Bulgaria; 2"Onkoderma"- Ambulatory Clinic for Dermatology and Skin Surgery, Sofia, Bulgaria; 3Department of General and Clinical Pathology, Medical Faculty, "Saint Kliment Ohridski University"; 4Dermatology Department, University Hospital of Coimbra, Praceta Mota Pinto, Portugal; 5Department of General and Clinical pathology, Medical University of Plovdiv, Bulgaria; 6Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Germany.
    We describe a rare case of a 28 year-old male patient presenting with pruritus and increased sensitivity of the prepuce accompanied by erythematous confluent papules, unilateral nevus flammeus (NF) along almost the whole length of the right lower limb and two dysplastic nevi (DN), one located on the mid back and the other on the medial border of the right fifth toe, the latter coinciding with the NF. A biopsy of the prepuce revealed lichen sclerosus et atrophicus (LSA). Mental health assessment revealed anxiety disorder and predisposition to panic attacks. Read More

    Incidence of atypical nevi in Olmsted County: an epidemiological study.
    J Cutan Pathol 2016 Jul 31;43(7):557-63. Epub 2016 Mar 31.
    Department of Dermatology, Mayo Clinic, Rochester, MN, USA.
    Background: The association of atypical nevi with melanoma and other forms of skin cancer has not been clearly defined.

    Methods: We studied 631 patients with first lifetime diagnosis of mild, moderate or severely atypical nevus from 2000 through 2005, identified through a population-based approach.

    Results: Age at first diagnosis differed significantly between men and women (p<. Read More

    Familial atypical multiple mole melanoma (FAMMM) syndrome: history, genetics, and heterogeneity.
    Fam Cancer 2016 Jul;15(3):487-91
    Department of Preventive Medicine, Creighton University, 2500 California Plaza, Omaha, NE, 68178, USA.
    Approximately 5-10 % of cutaneous melanoma occurs in kindreds with a hereditary predisposition. Mutations in the CDKN2A gene are found to occur in approximately 20-40 % of these kindreds. The first historical mention of what is now called the familial atypical multiple mole melanoma syndrome appears to be from 1820, with more reports throughout the 1950s, 1960s, and later years. Read More

    The utility of dermoscopy-guided histologic sectioning for the diagnosis of melanocytic lesions: A case-control study.
    J Am Acad Dermatol 2016 Jun 28;74(6):1107-13. Epub 2016 Jan 28.
    Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. Electronic address:
    Background: Dermoscopy allows for visualization of morphologic structures beyond the epidermis, including features that may indicate early malignant transformation. However, dermoscopic features are rarely considered during routine histologic sectioning, and areas of clinical concern may be missed during microscopic evaluation.

    Objective: We assessed the diagnostic impact of a dermoscopy-guided micropunch score for the evaluation of melanocytic lesions. Read More

    A nongrading histologic approach to Clark (dysplastic) nevi: A potential to decrease the excision rate.
    J Am Acad Dermatol 2016 Jan 6;74(1):68-74. Epub 2015 Nov 6.
    Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania. Electronic address:
    Background: Despite a lack of evidence that dysplastic nevi are precursors to melanoma, a large proportion of dermatologists continue to treat them as such. Emerging data suggest that histologic grading approach may result in many unnecessary excisions.

    Objective: Using a nongrading approach to diagnosis of Clark/dysplastic nevi, the current study sought to define and determine the diagnostic uncertainty rate, and to report on the results of re-excisions of such lesions. Read More

    IMP-3 EXPRESSION IN BENIGN MELANOCYTIC NEVI, DYSPLASTIC NEVI AND MALIGNANT MELANOMA: PRELIMINARY FINDINGS IN BULGARIAN PATIENTS.
    J Biol Regul Homeost Agents 2015 Jul-Sep;29(3):695-9
    “Onkoderma” –Policlinic for Dermatology, Venereology and Dermatologic Surgery, Sofia, Bulgaria.
    IMP-3 is generally considered as an oncofetal protein, which plays a critical role in regulation of cell proliferation via an IGF-II-dependent pathway in K562 leukemia cells. IMP-3 expression has been detected in malignancies with various origins, while its appearance in adult tissue is generally considered abnormal, with some exceptions. IMP3 is also considered a prognostic biomarker in patients with renal cell carcinoma and clear-cell type ovarian carcinoma, hepatocellular carcinoma, pancreatic ductal adenocarcinoma and in patients with poorly differentiated thyroid carcinoma and uterine cervical carcinomas, testicular cancer and malignant melanoma. Read More

    Immunosuppression is an independent prognostic factor associated with aggressive tumor behavior in cutaneous melanoma.
    J Am Acad Dermatol 2015 Sep 21;73(3):461-6. Epub 2015 Jul 21.
    Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; Robert H. Lurie Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. Electronic address:
    Background: A number of factors other than those identified by the American Joint Committee on Cancer (AJCC) may have prognostic significance in the evaluation of melanoma.

    Objective: We sought to evaluate commonly recorded clinical features potentially associated with aggressive melanoma.

    Methods: We conducted a retrospective case-control study. Read More

    Multiple Cutaneous Melanomas and Clinically Atypical Moles in a Patient With a Novel Germline BAP1 Mutation.
    JAMA Dermatol 2015 Nov;151(11):1235-9
    Wellman Center for Photomedicine and Department of Dermatology, Massachusetts General Hospital, Harvard University, Boston4Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston.
    Importance: Several kindreds having germline BAP1 mutations with a propensity for uveal and cutaneous melanomas and other internal malignancies have been described in an autosomal dominant tumor predisposition syndrome. However, clinically atypical moles have not been previously recognized as a component of this syndrome, to our knowledge. We describe the first kindred to date with a germline mutation in BAP1 associated with multiple cutaneous melanomas and classic dysplastic nevus syndrome. Read More

    Teledermatology-directed surgical care is safe and reduces travel.
    J Telemed Telecare 2016 Mar 26;22(2):121-6. Epub 2015 Jun 26.
    VA Puget Sound Health Care System, Seattle Division, USA University of Washington, Department of Medicine (Dermatology), Seattle, USA
    Methods: We conducted a retrospective chart review and identified 186 Veterans in the VA Corporate Data Warehouse as having malignant melanomas or severely dysplastic nevi during the four-year period of observation from 1 July 2009 to 30 June 2013 and met inclusion and exclusion criteria for analysis.

    Results: Three hundred and sixty-six surgical procedures were performed for diagnosis and treatment of these conditions including biopsy and wide-local excision, of which 189 carefully selected cases were performed by primary care clinicians with 2.0% biopsy complication rate and a 7. Read More

    Pancreatic cancer-associated gene polymorphisms in a nation-wide cohort of p16-Leiden germline mutation carriers; a case-control study.
    BMC Res Notes 2015 Jun 26;8:264. Epub 2015 Jun 26.
    Department of Clinical Genetics, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.
    Background: The p16-Leiden founder mutation in the CDKN2A gene is the most common cause of Familial Atypical Multiple Mole Melanoma (FAMMM) syndrome in the Netherlands. Individuals with this mutation are at increased risk for developing melanoma of the skin, as well as pancreatic cancer. However, there is a notable interfamilial variability in the occurrence of pancreatic cancer among p16-Leiden families. Read More

    Dysplastic nevus: Fact and fiction.
    J Am Acad Dermatol 2015 Sep 30;73(3):507-12. Epub 2015 May 30.
    Department of Dermatology, University of Connecticut Health Center, Farmington, Connecticut. Electronic address:
    The term "dysplastic nevus" (DN) implies that this nevus exists as a distinct and defined entity of potential detriment to its host. We examine the current data, which suggest that this entity exists as histologically and possibly genetically different from common nevus, with some overlapping features. Studies show that a melanoma associated with a nevus is just as likely to arise in a common nevus as in DN. Read More

    Activation of the Mitochondrial Fragmentation Protein DRP1 Correlates with BRAF(V600E) Melanoma.
    J Invest Dermatol 2015 Oct 1;135(10):2544-2547. Epub 2015 Jun 1.
    Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA; The Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA; The Diabetes, Obesity, and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA. Electronic address:

    Practical application of new technologies for melanoma diagnosis: Part II. Molecular approaches.
    J Am Acad Dermatol 2015 Jun;72(6):943-58; quiz 959-60
    Department of Dermatology, University of Utah Health Sciences Center, Salt Lake City, Utah; Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah. Electronic address:
    The criterion standard for diagnosing cutaneous melanoma continues to be histologic examination. However, classifying some melanocytic lesions by conventional microscopy can be problematic if they exhibit some architectural or morphologic characteristics of both nevus and melanoma. Moreover, histologic appearance does not always predict biologic behavior. Read More

    Dysplastic Nevus: Management by Canadian Dermatologists.
    J Cutan Med Surg 2015 Sep-Oct;19(5):457-63. Epub 2015 Apr 1.
    Division of Dermatology, Toronto Western Hospital, Toronto, Canada Lynde Center for Dermatology, Markham, Canada.
    Background: The management of dysplastic nevi is controversial. No studies have collected data regarding management of the lesion amongst Canadian dermatologists.

    Objective: To provide a comprehensive review of what the prevailing opinions are, regarding treatment and terminology of dysplastic nevi, amongst Canadian dermatologists. Read More

    Automatic differentiation of melanoma from dysplastic nevi.
    Comput Med Imaging Graph 2015 Jul 7;43:44-52. Epub 2015 Mar 7.
    Le2i-UMR CNRS 6306, Université de Bourgogne, BP 47870, 21078 Dijon, France.
    Malignant melanoma causes the majority of deaths related to skin cancer. Nevertheless, it is the most treatable one, depending on its early diagnosis. The early prognosis is a challenging task for both clinicians and dermatologist, due to the characteristic similarities of melanoma with other skin lesions such as dysplastic nevi. Read More

    Melanocytic naevi clustered on normal background skin.
    Clin Exp Dermatol 2015 Apr 22;40(3):231-7. Epub 2015 Feb 22.
    Department of Dermatology, Queen Elizabeth Hospital, King's Lynn, UK.
    Several types of maculopapular melanocytic naevi can occur in a multiple form, and be arranged in a nonrandom fashion on the skin. The most frequently reported segmentally grouped naevi are lentigines. Two types of segmentally arranged lentigines probably exist. Read More

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