115,990 results match your criteria Atypical Fibroxanthoma


Patterns of infiltration and local recurrences of various types of cutaneous sarcomas following three-dimensional histology.

J Dtsch Dermatol Ges 2018 Dec;16(12):1434-1442

Department of Dermatology, Eberhardt Karls University, Tübingen Germany.

Background: Cutaneous sarcomas are rare and characterized by pathogenetic heterogeneity. Knowledge about local infiltration patterns and recurrence rates may be useful in improving patient care and outcomes. The objective of the present study was to compare these two characteristics in sarcomas that had been treated using the identical surgical procedure. Read More

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December 2018

Characterization of the atypical Ppz/Hal3 phosphatase system from the pathogenic fungus Cryptococcus neoformans.

Mol Microbiol 2018 Dec 8. Epub 2018 Dec 8.

Departament de Bioquímica i Biologia Molecular and Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain.

Ppz Ser/Thr protein phosphatases (PPases) are found only in fungi and have been proposed as potential antifungal targets. In Saccharomyces cerevisiae Ppz1 (ScPpz1) is involved in regulation of monovalent cation homeostasis. ScPpz1 is inhibited by two regulatory proteins, Hal3 and Vhs3, which have moonlighting properties, contributing to the formation of an unusual heterotrimeric PPC decarboxylase (PPCDC) complex crucial for CoA biosynthesis. Read More

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December 2018

The golden paradox - a new heterokont lineage with chloroplasts surrounded by two membranes.

J Phycol 2018 Dec 9. Epub 2018 Dec 9.

School of BioSciences, University of Melbourne, Victoria, 3010, Australia.

A marine, sand-dwelling, golden-brown alga is described from clonal cultures established from a high intertidal pool in southeastern Australia. This tiny, unicellular species, which we call the "golden paradox" (Chrysoparadoxa australica gen. et sp. Read More

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December 2018

The array of clinical phenotypes of males with mutations in Methyl-CpG binding protein 2.

Am J Med Genet B Neuropsychiatr Genet 2018 Dec 7. Epub 2018 Dec 7.

University of Alabama at Birmingham, Birmingham, Alabama.

Mutations in the X-linked gene MECP2 are associated with a severe neurodevelopmental disorder, Rett syndrome (RTT), primarily in girls. It had been suspected that mutations in Methyl-CpG-binding protein 2 (MECP2) led to embryonic lethality in males, however such males have been reported. To enhance understanding of the phenotypic spectrum present in these individuals, we identified 30 males with MECP2 mutations in the RTT Natural History Study databases. Read More

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December 2018

Role and mechanism of Dvl3 in the esophageal squamous cell carcinoma.

Eur Rev Med Pharmacol Sci 2018 Nov;22(22):7716-7725

Department of Gastroenterology, First Affiliated Hospital of Henan University of TCM, Henan, China.

Objective: The purpose of this project was to investigate the expression of Dishevelled-3 (Dvl3) in esophageal squamous cell carcinoma and cultured cells, and to determine the consequence of Dvl3 silencing in the tumorous properties of esophageal squamous cell carcinoma cells.

Patients And Methods: The expression of Dvl3 mRNA and protein in 50 cases of esophageal squamous cell carcinoma was detected. The expression of Dvl3 mRNA and protein was significantly elevated in esophageal squamous cell carcinoma tissues compared with atypical hyperplasia and normal esophageal mucosa. Read More

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November 2018

[The syndrome of inappropriate diuretic hormone secretion (SIADH) ending lethal during the use of paliperidon and lamotrigine].

Tijdschr Psychiatr 2018 ;60(12):848-851

Hyponatremia, as a result of the syndrome of inappropriate antidiuretic hormone secretion (SIADH), is well known with the use of nearly all antipsychotics and mood stabilizers. The first symptoms are atypical and are not always mentioned by the patient. However, not recognising the syndrome in due time can be lethal. Read More

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January 2018

Gait festination in parkinsonism: introduction of two phenotypes.

J Neurol 2018 Dec 7. Epub 2018 Dec 7.

Department of Neurology, Centre of Clinical Neuroscience, First Faculty of Medicine, General University Hospital, Charles University, Prague, Czech Republic.

Gait festination is one of the most characteristic gait disturbances in patients with Parkinson's disease or atypical parkinsonism. Although festination is common and disabling, it has received little attention in the literature, and different definitions exist. Here, we argue that there are actually two phenotypes of festination. Read More

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December 2018

Overall Survival of Primary Intracranial Atypical Teratoid Rhabdoid Tumor Following Multimodal Treatment: A Pooled Analysis of Individual Patient Data.

Neurosurg Rev 2018 Dec 8. Epub 2018 Dec 8.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Tiantan Xili 6, Dongcheng District, Beijing, People's Republic of China.

No standard treatment protocol to guide the management of the primary central nervous system atypical teratoid rhabdoid tumors (ATRTs). To evaluate the efficacy of GTR (gross total resection), RT (radiotherapy), CCMT (conventional chemotherapy), or intensified chemotherapy (ICMT) and verify the optimal treatment strategy. A total of 501 cases (18 cases from our center and 483 cases from published literature) were eligible for analysis. Read More

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December 2018

Selective adrenergic alpha2C receptor antagonist ameliorates acute phencyclidine-induced schizophrenia-like social interaction deficits in rats.

Psychopharmacology (Berl) 2018 Dec 10. Epub 2018 Dec 10.

School of Pharmacy, University of Eastern Finland, P.O. Box 1627, FI-70211, Kuopio, Finland.

Rationale: Social withdrawal is a core feature of the negative symptoms of schizophrenia. Currently available pharmacotherapies have only limited efficacy towards the negative symptoms, i.e. Read More

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December 2018

Comparative study of intestinal malrotation in infant, children, and adult in a tertiary care center in India.

Indian J Gastroenterol 2018 Dec 7. Epub 2018 Dec 7.

Department of Gastroenterology, Patna Medical College and Hospital, Ashok Rajpath Road, Patna University Campus, Patna, 800 001, India.

Background: Intestinal malrotation (IM) is an uncommon condition and has varied presentation in different age groups. The study was aimed to evaluate differences in the clinical presentation, diagnosis, treatment, and outcome of IM in infants, children, and adults.

Methods: Data were collected from records of 79 patients with IM. Read More

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December 2018

Diagnostic Utility of Isolated Tube C Positivity in T-Cell Receptor β Testing Using BIOMED-2 Primers.

Am J Clin Pathol 2018 Dec 8. Epub 2018 Dec 8.

Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA.

Objectives: T-cell receptor (TCR) gene rearrangement studies are widely used for assessing T-cell clonality. The frequency and significance of clonal peaks restricted to TCR β (TCRB) tube C are uncertain. We retrospectively reviewed 80 TCR studies performed on bone marrow/peripheral blood. Read More

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December 2018

[Prevalence of dengue and leptospira in febrile patients of the general hospital of specialities in Mexico].

Rev Chilena Infectol 2018 ;35(3):332-333

Centro de Investigaciones Biomédicas, Universidad Autónoma de Campeche, Campeche, México.

Among the infectious diseases characterized by a febrile picture are: dengue, leptospirosis, rickettsiosis and salmonellosis, among others. The objective of this study was to identify IgM antibodies against dengue and Leptospira in febrile patientes. The seropositivity for IgM antibodies to dengue was 34%; 26. Read More

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January 2018

Abdominal ultrasound in paraneoplastic Pyoderma gangrenosum caused by renal carcinoma.

Med Ultrason 2018 Dec;20(4):541-542

2nd Medical Clinic, UMF Iuliu Hatieganu University, Cluj-Napoca, Romania.

We present the case of a 60-year-old male patient, with refractory ulcers in the groin. Ultrasoundand CT showed a large vascularized tumor of the kidney with cystic parts and inhomogeneous dynamic behaviour. Histology demonstrated Pyoderma gangrenosum (ulcer) and well differentiated adenocarcinoma (kidney). Read More

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December 2018

Surgical Treatment of the Atypical Femoral Fracture: Overcoming Femoral Bowing.

Hip Pelvis 2018 Dec 6;30(4):202-209. Epub 2018 Dec 6.

Department of Orthopaedic Surgery, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea.

Atypical femoral fractures differ from ordinary femoral diaphyseal or subtrochanteric fractures in several aspects. Although several authors have reported the results of surgical treatment for atypical femoral fractures, the rate of complications (e.g. Read More

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December 2018

Atypical electrocardiographic manifestations of ischemia: a case of dynamic Wellens patterns.

J Geriatr Cardiol 2018 Nov;15(11):710-712

Department of Medicine and Therapeutics, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, China.

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November 2018

Combination of acquired von Willebrand syndrome (AVWS) and Glanzmann thrombasthenia in monoclonal gammopathy of uncertain significance (MGUS), a case report.

Thromb J 2018 26;16:30. Epub 2018 Nov 26.

Department of Molecular Medicine and Haematology, Faculty of Health Sciences, University of the Witwatersr and National Health Laboratory Services, 7 York Road, Parktown, Johannesburg, 2196 South Africa.

Background: Autoimmune paraphenomena, are associated with B-cell lymphoproliferative disorders, including monoclonal gammopathy of uncertain significance. These paraphenomena can rarely include acquired bleeding disorders.

Case Presentation: This case study reports an unusual clinical presentation of 2 acquired bleeding disorders, Acquired von Willebrand syndrome (disease) and Acquired Glanzmann's thrombasthenia, in an elderly patient with monoclonal gammopathy of uncertain significance. Read More

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November 2018

Draft Whole-Genome Sequences of 10 Atypical Enteropathogenic Escherichia coli Strains Isolated in Brazil.

Microbiol Resour Announc 2018 Dec 6;7(22). Epub 2018 Dec 6.

Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.

The number of diarrhea cases caused by atypical enteropathogenic Escherichia coli (aEPEC) has been increasing worldwide. Here, we report the draft whole-genome sequences of 10 aEPEC strains isolated in Brazil. These sequences will provide an important source for future studies concerning aEPEC pathogenicity and genetic markers of potentially virulent strains. Read More

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December 2018

Draft Genome Sequences of the Type Strains of Three Subspecies and Atypical Peach-Colored Strains Isolated from Tomato.

Microbiol Resour Announc 2018 Nov 8;7(18). Epub 2018 Nov 8.

INRA, Agrocampus-Ouest, SFR 4207 QUASAV, Université d'Angers, Beaucouzé, France.

Here, we present the draft genome sequences of 10 Clavibacter sp. strains, including the type strains of different subspecies of Clavibacter michiganensis and a potentially novel species within the genus. Genome lengths of the strains varied between 2,982,864 and 3,288,331 bp, with G+C contents of 72. Read More

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November 2018

High-Quality Draft Genome Sequence of sp. Strain CPBF 424, a Walnut-Pathogenic Strain with Atypical Features.

Microbiol Resour Announc 2018 Oct 18;7(15). Epub 2018 Oct 18.

CIBIO-Centro de Investigação em Biodiversidade e Recursos Genéticos, InBIO Laboratório Associado, Microbial Diversity and Evolution Group, Universidade do Porto, Vairão, Portugal.

We report here the draft genome sequence of sp. strain CPBF 424, isolated from a diseased walnut tree. Multilocus sequence analysis showed that this walnut-pathogenic isolate is located between the nonpathogenic X. Read More

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October 2018

The functional differentiation of the post-PKS tailoring oxygenases contributed to the chemical diversities of atypical angucyclines.

Synth Syst Biotechnol 2018 Dec 14;3(4):275-282. Epub 2018 Nov 14.

State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, People's Republic of China.

Angucyclines are one of the largest families of aromatic polyketides with various chemical structures and bioactivities. Decades of studies have made it easy for us to depict the picture of their early biosynthetic pathways. Two families of oxygenases, the FAD-dependent oxygenases and the ring opening oxygenases, contribute to the formation of some unique skeletons of atypical angucyclines. Read More

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December 2018

Unknown primary large-cell neuroendocrine tumor.

Autops Case Rep 2018 Apr-Jun;8(2):e2018025. Epub 2018 Jun 8.

a Centro Hospitalar de São João, Medical Oncology Department. Porto, Portugal.

Large-cell neuroendocrine tumors (NETs) are poorly differentiated malignancies of rare incidence and aggressive nature. NETs mostly arise in the lung followed by the gastrointestinal tract, although they are potentially ubiquitous throughout the body. Primary unknown NET has a worse prognosis and shorter survival comparing with other NETs, with limited available data in the literature concerning this subgroup. Read More

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Mycobacterium tuberculosis Infection in the Setting of Interstitial Lung Disease: Coincidence or Bad Luck?

Cureus 2018 Oct 1;10(10):e3391. Epub 2018 Oct 1.

Pulmonology, New York Presbyterian Hospital Queens, New York, USA.

Mycobacterium tuberculosis (MTB) infection is the ninth leading cause of death worldwide, with many individuals with undiagnosed active or latent disease. The presence of parenchymal lung disease, such as interstitial lung disease (ILD), has been suggested to increase the risk of pulmonary tuberculosis (TB). In the clinical setting of ILD, the diagnosis of an underlying MTB infection may be challenging due to the interstitial process and underlying fibrosis, which may mask the infection. Read More

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October 2018

Postmortem detection and histopathological features of canine spirocercosis-induced putative esophageal chondrosarcoma.

Vet World 2018 Nov 3;11(10):1376-1379. Epub 2018 Oct 3.

Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, Sri Lanka.

Aim: The objective of this study was to describe and characterize the postmortem and histopathological findings of putative esophageal chondrosarcoma associated with .

Materials And Methods: Spirocerca-associated esophageal nodules were collected from 54 dogs at postmortem examination and were stained with hematoxylin and eosin. Of the cases examined, 15 were selected randomly for further investigation, of which 11 were classified as non-neoplastic nodules while 4 had changes reflecting a neoplastic process. Read More

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November 2018

Wernicke Encephalopathy with Atypical Findings on Magnetic Resonance Imaging.

Ann Indian Acad Neurol 2018 Oct-Dec;21(4):328-330

Department of Pathology, Yashoda Superspeciality Hospitals, Hyderabad, Telangana, India.

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December 2018

Restriction Fragment Length Polymorphism-based Genotyping of from Autopsy-Proven Cases of Acquired Immunodeficiency Syndrome-associated Cerebral Toxoplasmosis.

Ann Indian Acad Neurol 2018 Oct-Dec;21(4):250-255

Department of Microbiology, Kidwai Cancer Institute, Bengaluru, Karnataka, India.

Context: Published data on genetic characterization of () from clinical cases of toxoplasmosis from India is lacking.

Aims: The present study was aimed at identifying genetic types of in fatal cases of cerebral toxoplasmosis (CT) associated with HIV, from India.

Settings And Design: Archived tissues of CT were obtained postmortem from 25 acquired immunodeficiency syndrome patients between 2000 and 2014. Read More

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December 2018

Uncoupled activation and cyclization in catmint reductive terpenoid biosynthesis.

Nat Chem Biol 2019 Jan 10;15(1):71-79. Epub 2018 Dec 10.

The John Innes Centre, Department of Biological Chemistry, Norwich Research Park, Norwich, UK.

Terpene synthases typically form complex molecular scaffolds by concerted activation and cyclization of linear starting materials in a single enzyme active site. Here we show that iridoid synthase, an atypical reductive terpene synthase, catalyzes the activation of its substrate 8-oxogeranial into a reactive enol intermediate, but does not catalyze the subsequent cyclization into nepetalactol. This discovery led us to identify a class of nepetalactol-related short-chain dehydrogenase enzymes (NEPS) from catmint (Nepeta mussinii) that capture this reactive intermediate and catalyze the stereoselective cyclisation into distinct nepetalactol stereoisomers. Read More

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January 2019

[Fast-track rehabilitation after anatomical lung resection: prospective single-center non-randomized trial].

Khirurgiia (Mosk) 2018 (11):5-10

Vishnevsky Institute of Surgery of Healthcare Ministry of Russia, Moscow, Russia.

Aim: To present the results of fast track rehabilitation after anatomical lung resection.

Material And Methods: Single-center prospective non-randomized trial has included patients for the period December 2014 - December 2016. Conventional protocol was applied in 124 patients, 58 patients after atypical lung resections or pneumonectomy were excluded from the study. Read More

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January 2018

Ischemic Optic Neuropathy Secondary to Intravascular Lymphoma.

J Neuroophthalmol 2018 Oct 23. Epub 2018 Oct 23.

Departments of Ophthalmology (MD, JW, CO), Neurology (MD, AEM), and Pathology (EL), Weill Cornell Medical College, New York, New York.

Background: To describe a case of optic neuropathy associated with intravascular lymphoma (IVL).

Methods: Case report and review of the literature.

Results: A case of asymmetric binocular vision loss is described, preceded by transient vision loss. Read More

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October 2018

Stage IV Gestational Choriocarcinoma Diagnosed in the Third Trimester.

Obstet Gynecol 2018 Dec 4. Epub 2018 Dec 4.

Departments of Obstetrics and Gynecology and Pathology, Tufts Medical Center, Boston, Massachusetts.

Background: Gestational trophoblastic neoplasia rarely occurs in term pregnancies. Stage IV choriocarcinoma treated with conventional chemotherapy can result in death as a result of hemorrhagic sequelae at tumor sites.

Case: A 30-year-old woman at 34 weeks of gestation presented with a persistent cough, worsening dyspnea, and vaginal bleeding. Read More

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December 2018
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Posterior reversible encephalopathy syndrome.

Curr Opin Neurol 2018 Dec 10. Epub 2018 Dec 10.

Center for Stroke Research Berlin (CSB).

Purpose Of Review: Posterior reversible encephalopathy syndrome (PRES) is a clinicoradiological syndrome characterized by acute cerebral endotheliopathy with consecutive disruption of the blood-brain barrier and vasogenic edema. Since its first description in 1996, PRES is increasingly recognized. However, many aspects of this syndrome with its wide spectrum of clinical and radiological features are still incompletely understood. Read More

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December 2018

Antipsychotics and pituitary tumors: an analysis of the European pharmacovigilance database (EudraVigilance).

Int Clin Psychopharmacol 2018 Dec 10. Epub 2018 Dec 10.

Basque Pharmacovigilance Unit, Galdakao-Usánsolo Hospital, Galdakao.

One of the possible long-term consequences of antipsychotic-induced hyperprolactinemia is the development of pituitary tumors - prolactinomas. So far, two pharmacovigilance studies of spontaneous adverse event report databases have suggested an increased risk, whereas a longitudinal study carried out with risperidone showed no evidence of increased risk of tumors with mass effect. Besides, information on amisulpride and paliperidone is lacking. Read More

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December 2018

Two atypical presentations of lepra reactions.

Int J Mycobacteriol 2018 Oct-Dec;7(4):390-393

Army College of Medical Sciences, New Delhi, India.

Leprosy or Hansen's disease is a chronic infectious granulomatous disease with varied presentation, especially in the setting of lepra reactions. We report two such atypical presentations each of Type I and Type II Lepra reactions; the first being an elderly male presenting with fever, while the second case being of a young boy being evaluated for cervical lymphadenitis. Read More

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December 2018

The association between computed tomography scan findings of pulmonary infection caused by atypical mycobacteria and bacillus count in sputum samples.

Int J Mycobacteriol 2018 Oct-Dec;7(4):355-357

Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: The use of imaging techniques is important for prompt diagnosis and treatment of atypical mycobacterial infections; it also reduces the burden of these infections. The purpose of the present study was to determine the association between computed tomography (CT) scan findings of pulmonary infection caused by atypical mycobacteria and bacillus count in sputum samples.

Methods: This cross-sectional, observational, comparative study included 50 consecutive patients with pulmonary infection caused by atypical mycobacteria, who were hospitalized in Masih-Daneshvari Hospital of Tehran, Iran during 2012-2017. Read More

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December 2018

Putative histiocytic sarcoma in redfin needlefish Strongylura notata (Beloniformes: Belonidae) in Florida, USA.

Dis Aquat Organ 2018 Dec;132(1):57-78

Fish and Wildlife Research Institute, Florida Fish and Wildlife Conservation Commission, St. Petersburg, Florida 33701, USA.

Redfin needlefish Strongylura notata from Florida coastal waters were observed with unusual neoplastic lesions. Affected specimens were collected from 1 Atlantic estuary (Indian River Lagoon, prevalence = 0.32%, n = 5314) and 2 Gulf of Mexico estuaries (Tampa Bay, prevalence = 0. Read More

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December 2018

Acid-denatured small heat shock protein HdeA from forms reversible fibrils with an atypical secondary structure.

J Biol Chem 2018 Dec 10. Epub 2018 Dec 10.

Graduate School of Sustainability Science, Tottori University, Japan.

The periplasmic small heat shock protein HdeA from is inactive under normal growth conditions (at pH 7) and activated only when cells are subjected to a sudden decrease in pH, converting HdeA into an acid-denatured active state. Here, using in vitro fibrillation assays, transmission EM, atomic-force microscopy, and CD analyses, we found that when HdeA is active as a molecular chaperone, it is also capable of forming inactive aggregates that, at first glance, resemble amyloid fibrils. We noted that the molecular chaperone activity of HdeA takes precedence over fibrillogenesis under acidic conditions, as the presence of denatured substrate protein was sufficient to suppress HdeA fibril formation. Read More

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December 2018

Lysine methylation by the mitochondrial methyltransferase FAM173B optimizes the function of mitochondrial ATP synthase.

J Biol Chem 2018 Dec 10. Epub 2018 Dec 10.

Department of Biosciences, University of Oslo, Norway.

Lysine methylation is an important post-translational modification that is also present on mitochondrial proteins, but the mitochondrial lysine-specific methyltransferases (KMTs) responsible for modification are in most cases unknown. Here, we set out to determine the function of human family with sequence similarity 173 member B (FAM173B), a mitochondrial methyltransferase (MTase) reported to promote chronic pain. Using bioinformatics analyses and biochemical assays, we found that FAM173B contains an atypical, non-cleavable mitochondrial targeting sequence responsible for its localization to mitochondria. Read More

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December 2018

Early and long-term electroclinical features of patients with epilepsy and PCDH19 mutation.

Epileptic Disord 2018 Dec 10. Epub 2018 Dec 10.

Pediatric Neurology Department, Centre de Référence des Épilepsies Rares, Necker Enfants Malades Hospital, Paris, Inserm U1129, Paris; University Paris Descartes; CEA, Gif sur Yvette.

Protocadherin 19 (PCDH19) mutations have been identified in epilepsy in females with mental retardation as well as patients with a "Dravet-like" phenotype. We aimed to elucidate the electroclinical phenotype associated with PCDH19 mutation, which is currently difficult to identify at onset leading to a delay in diagnosis. We retrospectively reviewed clinical and EEG data for 13 consecutive patients with PCDH19 mutations or deletions diagnosed at our centers from 2009 to 2011, and followed these patients into adolescence and adulthood. Read More

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December 2018

Juvenile absence epilepsy relapsing as recurrent absence status, mimicking transient global amnesia, in an elderly patient.

Epileptic Disord 2018 Dec 10. Epub 2018 Dec 10.

IRCCS Institute of Neurological Sciences, Bologna, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.

We describe a 68-year-old woman who had typical absence seizures since 14 years of age. The absences were refractory to treatment and persisted into adulthood, with no seizure-free periods until seizure control at 59 years of age. After six years of being seizure-free, she presented with an episode characterized by mental confusion, abnormal behaviour, and amnesia, lasting for several hours. Read More

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December 2018

Rasmussen syndrome: an atypical presentation in ten patients.

Epileptic Disord 2018 Dec 10. Epub 2018 Dec 10.

Department of Neurosurgery, Hospital de Pediatría "Prof Dr Juan P Garrahan", Buenos Aires, Argentina.

The aim of this study was to analyse the electroclinical and imaging findings and outcome of patients with Rasmussen syndrome (RS) with atypical manifestations. We conducted a retrospective, descriptive study of 10 of 44 consecutive patients with RS with atypical features, followed between 1999 and 2017. Six patients were boys and four were girls. Read More

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December 2018

Detection of three novel atypical porcine pestivirus strains in newborn piglets with congenital tremor in southern China.

Infect Genet Evol 2018 Dec 6. Epub 2018 Dec 6.

College of Animal Science, South China Agricultural University & Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, Guangzhou 510642, PR China. Electronic address:

Atypical porcine pestivirus (APPV) have been discovered in swine herds from three provinces in China, suggesting a wide distribution in China. This study reports the occurrence of three novel APPV strains in China. They were detected from newborn piglets with clinical signs of congenital tremors (CT) in Guangdong Province, China. Read More

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December 2018

Recombinant noroviruses detected in Mid-West region of Brazil in two different periods 2009-2011 and 2014-2015: Atypical breakpoints of recombination and detection of distinct GII.P7-GII.6 lineages.

Infect Genet Evol 2018 Dec 5. Epub 2018 Dec 5.

Laboratory of Virology and Cell Culture, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, Goiás, Brazil. Electronic address:

Noroviruses are an important cause of acute gastroenteritis. The high incidence of norovirus is a reflection of its great genomic and antigenic variability resultant of evolutionary mechanisms, such as recombination. Herein, the main objective of this study was to characterize partially two regions of norovirus genome (RdRp and VP1) from fecal samples, collected in two different time periods (2009-2011 and 2014-2015) in the Mid-West region of Brazil. Read More

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December 2018

Incidence of epilepsy and associated factors in elderly patients in Germany.

Epilepsy Behav 2018 Dec 4;90:107-111. Epub 2018 Dec 4.

Epidemiology, IQVIA, Frankfurt, Germany. Electronic address:

Aims: Little is known about the recent epidemiology of epilepsy in the elderly in Germany. Therefore, the goal of this study was to analyze the incidence of epilepsy and associated factors in elderly patients followed in general practices in this country.

Methods: The incidence of epilepsy was estimated using data from all patients aged ≥60 years who were followed in 1203 general practices in Germany in 2017 (IQVIA Disease Analyzer database). Read More

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December 2018

Antipsychotic-induced metabolic alterations: recounting the mechanistic insights, therapeutic targets and pharmacological alternatives.

Eur J Pharmacol 2018 Dec 7. Epub 2018 Dec 7.

Pharmacology Research Laboratory, University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Study (UGC-CAS), Panjab University, Chandigarh-160014, India. Electronic address:

Atypical antipsychotics (AAPs) are the drug of choice in the management of mental illnesses by virtue of their advantage over typical antipsychotics i.e. least tendency of producing extrapyramidal motor symptoms (EPS) or pseudoparkinsonism. Read More

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December 2018

[Epstein-Barr virus primary infection in healthy children].

An Pediatr (Barc) 2018 Oct 24. Epub 2018 Oct 24.

Servicio de Pediatría, Hospital Lluís Alcanyís, Xátiva, Valencia, España.

Introduction: The aim of this study is to assess epidemiological, clinical and laboratory characteristics of primary infection by Epstein-Barr virus (EBV) in children without previous diagnosis of any immune disease and its relationship with clinical presentation.

Patients And Methods: A retrospective study was conducted on all children from 0 to 15 years with IgM against viral capsid of EBV positive or indeterminate during a 22 month period. Epidemiological, clinical and laboratory data were analysed and compared between typical (mononucleosis syndrome) and non-typical clinical symptoms. Read More

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October 2018

Carpal tunnel syndrome due to hibernoma of the wrist: Case report.

Hand Surg Rehabil 2018 Dec 5. Epub 2018 Dec 5.

Service de traumatologie orthopédie I, Hôpital militaire d'instruction Mohamed V, Hay Ryad (avenue des FAR), 10000 Rabat, Morocco.

Carpal tunnel syndrome (CTS) is the most frequent among entrapment neuropathies. The usual etiology is idiopathic, but can be caused by space-occupying lesions, a relatively rare condition. This condition becomes exceptional when the space-occupying lesion corresponds to a rare tumor whose location is atypical. Read More

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December 2018

G4Catchall: a G-quadruplex prediction approach considering atypical features.

Authors:
Osman Doluca

J Theor Biol 2018 Dec 6. Epub 2018 Dec 6.

Biomedical Engineering Department, Izmir University of Economics, Izmir, Turkey. Electronic address:

Motivation: In vivo discovery of G-quadruplex-forming sequences would provide the most relevant G-quadruplexes along a genomic DNA or an RNA molecule, although is difficult to perform due to the small size of G-quadruplexes, the existence of different topologies, and the additional influence of environmental factors and ligands during experimentation. In vitro discovery on the other hand is not only unable to simulate in vivo conditions but also, not practical for large sequences due to limited resources. The immediate solution continues to be the computational prediction although, not always in agreement with experimental findings. Read More

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December 2018

Kinesio Taping Application in Dysphonic Singers.

J Voice 2018 Dec 6. Epub 2018 Dec 6.

Ent Department, Yarmouk University, Irbid, Jordan.

Introduction: Kinesio Taping (KT) application in speech therapy has been studied in a few works about dysphonia, facial nerve palsy, sialorrhea, atypical deglutition, postsurgical recovery after thyroidectomy and laryngectomy. The aim of this study was the evaluation of the possible role of KT in supporting speech therapy in singers complaining of dysphonia using singing voice handicap index (SVHI), fundamental frequency (F0), shimmer, jitter and harmonic to noise ratio (mean H/N).

Materials And Methods: We enrolled consecutive singers and singing students complaining of dysphonia and voice problems. Read More

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December 2018

Scedosporium apiospermum invasive sinusitis presenting as extradural abscess.

Eur Ann Otorhinolaryngol Head Neck Dis 2018 Dec 4. Epub 2018 Dec 4.

Département d'otorhinolaryngologie/chirurgie cervico-faciale/chirurgie de la base du crâne, université Paris-Diderot, hôpital Lariboisière, AP-HP, Paris, France.

Introduction: Chronic invasive fungal rhinosinusitis (CIFR) is a rare entity generally observed in immunodepressed subjects. The pathogen most frequently identified is Aspergillus spp. Imaging generally reveals invasive pseudoneoplastic features. Read More

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December 2018

Does Surgical Treatment of Atypical Endometrial Hyperplasia Require Referral to a Gynecologic Oncologist?

Am J Obstet Gynecol 2018 Dec 7. Epub 2018 Dec 7.

Department of Obstetrics and Gynecology, Wake Forest University School of Medicine; Winston-Salem, NC.

Patients with atypical endometrial hyperplasia (AEH) in the United States are commonly referred to a gynecologic oncologist given a moderate risk of concurrent carcinoma. However, selective referral of patients to non-oncologic gynecologic surgeons for surgical treatment of AEH may offer increased access to care without compromising clinical outcomes. Non-oncologic surgeons who consider providing surgical treatment for AEH must be able to offer minimally invasive surgery when appropriate and have sufficient surgical volume to deliver optimal clinical outcomes. Read More

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December 2018

A pilot study of non-routine events in gynecological surgery: Type, impact, and effect.

Gynecol Oncol 2018 Dec 6. Epub 2018 Dec 6.

Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, USA; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA. Electronic address:

Objective: Quantifying non-routine events (NREs) assists with identify underlying sociotechnical factors that could lead to adverse events. NREs are considered any event that is unusual or atypical during surgical procedures. This study aimed to use prospective observations to characterize the occurrence of non-routine events in gynecological surgeries. Read More

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December 2018