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    666 results match your criteria Atypical Fibroxanthoma

    1 OF 14

    Metastatic melanoma with balloon/histiocytoid cytomorphology after treatment with immunotherapy: A histologic mimic and diagnostic pitfall.
    J Cutan Pathol 2018 Apr 19. Epub 2018 Apr 19.
    Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, TX.
    Epithelioid cells with foamy cytoplasm (histiocytoid features) are typical histopathologic findings among benign and malignant histiocytic neoplasms such as xanthoma and atypical fibroxanthoma. However, these changes are unusual in melanoma, which is typically composed of nested and variably pigmented atypical epithelioid cells. Here, we report a patient with metastatic melanoma in lymph nodes presenting with prominent balloon cell/histiocytoid features expressing melanocytic markers, after treatment with nivolumab. Read More

    An Unusual Case of Pinna Squamous Cell Carcinoma Arising Shortly after Resection of Atypical Fibroxanthoma.
    Case Rep Otolaryngol 2018 23;2018:6092169. Epub 2018 Jan 23.
    Department of Histopathology, Calderdale Royal Hospital, Halifax, UK.
    Objective: To report a unique case of pinna squamous cell carcinoma (SCC) arising shortly after resection of atypical fibroxanthoma (AFX) at the same site.

    Case Report: An 81-year-old gentleman presented with a nodular right pinna lesion. This was excised, and histology confirmed AFX. Read More

    Dermoscopy features of atypical fibroxanthoma: A multicenter study of the International Dermoscopy Society.
    Australas J Dermatol 2018 Mar 23. Epub 2018 Mar 23.
    Dermatology Unit, University of Campania Luigi Vanvitelli, Naples, Italy.
    Background/objectives: Little is known about the dermoscopic features of atypical fibroxanthoma.

    Methods: This was a case-control study. Atypical fibroxanthoma lesions were compared with a control group with non-melanoma skin cancer. Read More

    h-caldesmon immunoreactivity in atypical fibroxanthoma: implications for the differential diagnosis.
    Pathology 2018 Apr 1;50(3):358-361. Epub 2018 Mar 1.
    Biomedical Research Institute INCLIVA, Valencia, Spain; Department of Pathology, Hospital Clínico Universitario de Valencia, Valencia, Spain; University of Valencia, Valencia, Spain. Electronic address:

    Copy number variations in atypical fibroxanthomas and pleomorphic dermal sarcomas.
    Oncotarget 2017 Dec 25;8(65):109457-109467. Epub 2017 Nov 25.
    Institute of Pathology, University Hospital Cologne, Cologne, Germany.
    Atypical fibroxanthomas (AFX) and pleomorphic dermal sarcomas (PDS) are frequent cutaneous sarcomas typically arising on sun-exposed skin in elderly patients. In contrast to AFX, which generally do not recur after complete excision, PDS locally recur in up to 50% and metastasize in up to 20%. We recently detected characteristic UV-induced mutations as potential driver mutation in almost all PDS investigated as well as activating and gene mutations in around one third of our tumors representing targets for personalized treatments in patients with unresectable or metastasized PDS. Read More

    Genomic analysis of atypical fibroxanthoma.
    PLoS One 2017 15;12(11):e0188272. Epub 2017 Nov 15.
    Department of Dermatology, University of California, San Francisco, California, United States of America.
    Atypical fibroxanthoma (AFX), is a rare type of skin cancer affecting older individuals with sun damaged skin. Since there is limited genomic information about AFX, our study seeks to improve the understanding of AFX through whole-exome and RNA sequencing of 8 matched tumor-normal samples. AFX is a highly mutated malignancy with recurrent mutations in a number of genes, including COL11A1, ERBB4, CSMD3, and FAT1. Read More

    Atypical fibroxanthoma arising within erosive pustular dermatosis of the scalp.
    Cutis 2017 Sep;100(3):E14-E16
    Department of Dermatology, Upstate Medical University, Syracuse, New York, USA.
    We describe a painful atypical fibroxanthoma (AFX) arising in a setting of erosive pustular dermatosis of the scalp. Complete excision was curative and also was associated with resolution of pain and clearance of the erosive pustular dermatosis of the scalp. We review the diagnosis and management of AFX and discuss the role of actinic damage in this process. Read More

    Atypical fibroxanthoma and pleomorphic dermal sarcoma harbor frequent NOTCH1/2 and FAT1 mutations and similar DNA copy number alteration profiles.
    Mod Pathol 2018 Mar 3;31(3):418-428. Epub 2017 Nov 3.
    Dermatopathology Friedrichshafen, Friedrichshafen, Germany.
    Atypical fibroxanthomas and pleomorphic dermal sarcomas are tumors arising in sun-damaged skin of elderly patients. They have differing prognoses and are currently distinguished using histological criteria, such as invasion of deeper tissue structures, necrosis and lymphovascular or perineural invasion. To investigate the as-yet poorly understood genetics of these tumors, 41 atypical fibroxanthomas and 40 pleomorphic dermal sarcomas were subjected to targeted next-generation sequencing approaches as well as DNA copy number analysis by comparative genomic hybridization. Read More

    Osseointegrated Prosthetic Ear Reconstruction in Cases of Skin Malignancy: Technique, Outcomes, and Patient Satisfaction.
    Ann Plast Surg 2018 Jan;80(1):32-39
    Background: Ear reconstruction with osseointegrated prosthetic implants is a well-established method of reconstruction after resection of skin malignancies on the external ear. There is limited literature reporting technique, outcomes, and patient satisfaction.

    Methods: We evaluated our outcomes over a 5-year period looking at osseointegrated prosthetic reconstruction after auriculectomy for external ear skin malignancies. Read More

    [A pink nodule on the face].
    Pan Afr Med J 2017 18;27:205. Epub 2017 Jul 18.
    Service de Dermatologie, Centre Hospitalier Universitaire Ibn Sina, Rabat, Maroc.
    We report the case of a 32-year old female patient, with no notable medical history, requiring dermatology consultation for evaluation of a nodule on her right cheek which had evolved over the past 10 years. Clinical examination showed a reddish dermal-based nodule with a smooth surface. The lesion measured 1cm in diameter and was located at the level of the right cheek (A). Read More

    Recurrent conjunctival atypical fibroxanthoma in Pigmentosum Xeroderma.
    Arch Soc Esp Oftalmol 2018 Feb 23;93(2):97-100. Epub 2017 Aug 23.
    Departamento de Oftalmología, Hospital Universitario y Politécnico la Fe, Valencia, España.
    Case Report: A 7 year-old boy with Xeroderma Pigmentosum (XP) and who presents a recurrent conjunctival atypical fibroxanthoma after two surgeries. This is the third procedure and the patient is treated with a surgical excision of the tumour and cryotherapy at the surgical bed. Due to the risk of recurrence, topical Mitomycin C 0,02% was added at post-operative care achieving a good clinical outcome. Read More

    Atypical fibroxanthoma management: Recurrence, metastasis and disease-specific death.
    Australas J Dermatol 2018 Feb 17;59(1):10-25. Epub 2017 Aug 17.
    Skin and Cancer Foundation, Sydney, New South Wales, Australia.
    Atypical fibroxanthoma (AFX) is a rare spindle cell neoplasm predominantly found on the head and neck of elderly individuals with sun-damaged skin, with no evidence-based guidelines for their management. A systematic retrospective review of the literature focusing on treatment modality found a recurrence and metastasis rate of 8.0% (5. Read More

    Fibrohistiocytic Tumors.
    Clin Lab Med 2017 Sep 15;37(3):603-631. Epub 2017 Jun 15.
    Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Mayo Clinic, Hilton 11, 200 First Street Southwest, Rochester, MN 55905, USA. Electronic address:
    Fibrohistiocytic tumors are a diverse group of reactive and neoplastic lesions including xanthoma, fibrous histiocytoma and its variants, solitary xanthogranuloma, dermatofibrosarcoma protuberans, and atypical fibroxanthoma. This article reviews some of the more commonly encountered fibrohistiocytic tumors with an emphasis on clinical presentation, macroscopic and histologic characteristics, molecular/cytogenetic findings where applicable, and differential diagnoses. Read More

    Conception and Management of a Poorly Understood Spectrum of Dermatologic Neoplasms: Atypical Fibroxanthoma, Pleomorphic Dermal Sarcoma, and Undifferentiated Pleomorphic Sarcoma.
    Curr Treat Options Oncol 2017 Aug;18(8):50
    Department of Dermatology, Stanford University School of Medicine, 450 Broadway Street Pavilion C, 2nd Floor, Redwood City, CA, 94063, USA.
    Opinion Statement: Atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS) tumors share many clinical, etiologic, and histologic features and likely represent components of a tumor spectrum. In dermatologic oncology, differentiating between AFX and PDS is pivotal as tumors with histological features consistent with PDS are more likely to behave in a clinically aggressive manner. Importantly, the term "pleomorphic dermal sarcoma" (PDS) is a more appropriate designation than "undifferentiated pleomorphic sarcoma" (UPS) for describing deeper, more aggressive, histologically high-grade cutaneous tumors that otherwise resemble AFX. Read More

    Clear-cell atypical fibroxanthoma: An unusual case in an unusual place.
    J Cutan Pathol 2017 Nov 22;44(11):951-953. Epub 2017 Aug 22.
    Ronald Reagan UCLA Medical Center, University of California, Los Angeles, California.
    Atypical fibroxanthoma represents a low-grade sarcoma that usually presents in the elderly population on sun-damaged areas of the head and neck regions. This neoplasm is characterized on histology by atypical pleomorphic, epithelioid to spindled cells, arranged in a haphazard pattern, set within a background of solar elastosis. In this case report, we present a unique case of the rare variant of clear-cell atypical fibroxanthoma arising in an unusual place, specifically the lower extremities. Read More

    Phosphohistone-H3 and Ki67: Useful Markers in Differentiating Dermatofibroma From Dermatofibrosarcoma Protuberans and Atypical Fibrohistiocytic Lesions.
    Am J Dermatopathol 2017 Jul;39(7):504-507
    *Department of Pathology, Baylor University Medical Center, Dallas, TX; †Department of Pathology, Pathologist Biomedical Laboratories, Dallas, TX; ‡Department of Pathology, UF Health, Jacksonville, Jacksonville, FL; §Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX; and ¶Department of Pathology, MD Anderson Cancer Center, Houston, TX.
    Dermatofibromas (DF) are common, benign, skin tumors, usually easily differentiated from dermatofibrosarcoma protuberans (DFSP) by the presence of a relative low cellularity, lesser degree of infiltration of subcutaneous tissue, and immunohistochemical pattern (eg, FXIIIa in DF and CD34 in DFSP). Atypical fibrohistiocytic lesions (AFL) have features intermediate to DF and DFSP (trunk location, storiform pattern, infiltration of the subcutaneous tissue, and focal expression of both CD34 and Factor XIIIa). It is unclear if mitotic counts/degree of proliferation is helpful to distinguish DF from DFSP. Read More

    Cutaneous sarcomas.
    J Dtsch Dermatol Ges 2017 Jun;15(6):630-648
    Department of Dermatology and Allergology, Munich Technical University, Munich, Germany.
    Cutaneous sarcomas comprise a heterogeneous group of mesenchymal spindle cell tumors of the dermis and subcutis, one of the best-known entities being dermatofibrosarcoma protuberans. Other sarcomas addressed in this review include atypical fibroxanthoma, cutaneous undifferentiated pleomorphic sarcoma, leiomyosarcoma, liposarcoma, and angiosarcoma. With the exception of dermatofibrosarcoma protuberans, which has its peak incidence in middle-aged adults, cutaneous sarcomas usually occur in elderly individuals starting in the sixth or seventh decade of life. Read More

    Electronic brachytherapy management of atypical fibroxanthoma: report of 8 lesions.
    J Contemp Brachytherapy 2017 Apr 25;9(2):158-160. Epub 2017 Jan 25.
    DermaHealth Dermatology & Dermasurgery, Richland, WA, USA.
    Purpose: To evaluate the suitability of treating atypical fibroxanthoma (AFX), an uncommon skin malignancy, with electronic brachytherapy.

    Material And Methods: From Feb 2013 to Sep 2014, we were referred a total of 8 cases of AFX in 7 patients, all involving the scalp. All of them were treated with electronic brachytherapy 50 Kev radiations (Xoft Axxent, Fremont, California). Read More

    Atypical Fibroxanthoma Revisited.
    Surg Pathol Clin 2017 Jun 14;10(2):319-335. Epub 2017 Mar 14.
    Department of Pathology, University of Edinburgh, United Kingdom.
    Atypical fibroxanthoma (AFX) represents a rare mesenchymal neoplasm arising predominantly in the head and neck area of elderly patients. Clinically, the neoplasm is characterized by a rapid and exophytic growth with frequent ulceration of the epidermis. Histopathologically, AFX represents a well-circumscribed, dermal-based neoplasm composed of a variable admixture of large histiocytoid cells, enlarged spindled and epithelioid tumor cells, and multinucleated tumor giant cells with bizarre and pleomorphic nuclei. Read More

    Trichoscopic Patterns in Squamous Cell Carcinoma: : A Case Report.
    Int J Trichology 2016 Oct-Dec;8(4):191-194
    Department of Pathology, S Nijalingappa Medical College, Bagalkot, Karnataka, India.
    Squamous cell carcinoma (SCC) is the second most cutaneous malignancy after basal cell carcinoma (BCC) with increasing incidence. In the view its nodular manifestation; it can appear similar to nodular BCC, atypical fibroxanthoma, sclerosing liposarcoma and desmoplastic melanoma. Prognostic and therapeutic implications are different in all these conditions and thus their distinction becomes important. Read More

    Dermatomyofibromas Arising in Children: Report of Two New Cases and Review of the Literature.
    Pediatr Dermatol 2017 May 20;34(3):347-351. Epub 2017 Mar 20.
    Department of Dermatology, Mayo Clinic, Rochester, Minnesota.
    Dermatomyofibroma is a rare, benign mesenchymal proliferation not commonly reported in children. Two patients with biopsy-proven dermatomyofibroma were identified (one female, one male) at our institution, both with rather atypical clinical presentations. The clinical and histopathologic findings and a review of the literature are presented here. Read More

    Granular cell differentiation: A review of the published work.
    J Dermatol 2017 Mar;44(3):251-258
    Boston University School of Medicine, Boston, Massachusetts, USA.
    Since the initial description of the granular cell tumor in 1926, numerous other neoplasms, both benign and malignant, have been described to exhibit granular cell change. In most cases, diagnosis remains straightforward via recognition of retained histopathological morphology of the archetypal tumor, despite the presence of focal granular appearance. However, tumors with granular cell differentiation can present a diagnostic challenge either by mimicking alternative diagnoses, or by failing to exhibit architectural clues of the primary entity, thus requiring an immunohistochemical work-up. Read More

    Dermatofibroma-like granular cell tumour: a potential diagnostic pitfall.
    Pol J Pathol 2016;67(3):291-294
    The Fingerland Department of Pathology, Charles University in Prague, Faculty of Medicine and University Hospital in Hradec Králové, Czech Republic.
    Dermatofibroma-like granular cell tumour (GCT) is a rare entity, with only two cases having been described so far. We report another case in a 62-year-old woman, discuss histopathological features, and review other tumours in which granular changes have been observed. Our tumour was composed predominantly of oval-to-spindle granular cells with prominent nucleoli, arranged in short fascicles and storiform pattern, infiltrating around collagen bundles. Read More

    Aberrant tyrosinase expression in an atypical fibroxanthoma: A case report.
    J Cutan Pathol 2017 May 16;44(5):467-469. Epub 2017 Feb 16.
    Division of Dermatology, Rutgers University - New Jersey Medical School, Newark, New Jersey.
    Atypical fibroxanthoma (AFX) is a histologic mimicker of a variety of spindle cell neoplasms, and careful microscopic and immunohistochemical evaluation is critical in establishing the correct diagnosis. Here we report the histologic and immunohistochemical work up of a 1 cm nodule involving the left dorsal hand of a 66-year-old patient. Light microscopy revealed fascicles of spindled and pleomorphic cells within the dermis showing increased mitotic activity occurring in the background of sun-damaged skin. Read More

    LN2, CD10, and Ezrin Do Not Distinguish Between Atypical Fibroxanthoma and Undifferentiated Pleomorphic Sarcoma or Predict Clinical Outcome.
    Dermatol Surg 2017 Mar;43(3):431-436
    *Division of Dermatology, Department of Medicine, Vanderbilt University, Nashville, Tennessee; †Department of Dermatology, University of Oklahoma, Oklahoma City, Oklahoma; ‡Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut.
    Background: Atypical fibroxanthoma (AFX) is a rare cutaneous spindled cell neoplasm. For both diagnostic and therapeutic purposes, it is important to distinguish AFX from other poorly differentiated tumors, including undifferentiated pleomorphic sarcoma (UPS).

    Objective: The authors aimed to identify the clinical, histologic, and immunohistochemical expression of LN2, ezrin, and CD10 in AFX and UPS tumors. Read More

    Evidence-Based Medicine: Cutaneous Facial Malignancies: Nonmelanoma Skin Cancer.
    Plast Reconstr Surg 2017 Jan;139(1):181e-190e
    New York, N.Y. From the Dermatology Service and the Plastic Surgery Service, Memorial Sloan Kettering Cancer Center.
    Learning Objectives: After studying this article, the participant should be able to: 1. Identify clinical features of nonmelanoma skin cancer; 2. Distinguish low-risk versus high-risk basal cell carcinoma and squamous cell carcinoma; 3. Read More

    Incidence and Clinical Features of Rare Cutaneous Malignancies in Olmsted County, Minnesota, 2000 to 2010.
    Dermatol Surg 2017 Jan;43(1):116-124
    *Department of Dermatology, Mayo Clinic, Rochester, Minnesota;†Division of Biomedical Statistics and Informatics, Mayo Clinic Rochester, Minnesota;‡Division of Dermatologic Surgery, Mayo Clinic, Rochester, Minnesota.
    Background: The incidence of rare cutaneous malignancies is unknown. Current estimates of rare cutaneous malignancy incidences are based on broad epidemiologic data or single institution experiences, not population-based data.

    Objective: To determine the incidence of several rare nonmelanoma skin cancers. Read More

    Dermatofibroma of the eyelid with monster cells.
    Surv Ophthalmol 2017 Jul - Aug;62(4):533-540. Epub 2016 Dec 22.
    Department of Dermatology, Massachusetts General Hospital.
    Dermatofibromas are most frequently encountered in women on the lower extremities, often after minor trauma. A recurrent lesion of the right lower eyelid developed in a 64-year-old woman. It harbored "monster cells" that were large, with either multiple nuclei or a single, large, convoluted, and hyperchromatic nucleus. Read More

    Non-lymphoid lesions that may mimic cutaneous hematopoietic neoplasms histologically.
    Semin Diagn Pathol 2017 Jan 29;34(1):99-107. Epub 2016 Nov 29.
    From the Section of Dermatopathology, Division of Surgical Pathology & Cytopathology, University of Virginia Health System, Charlottesville, VA, USA.
    This review considers neoplastic lesions that originate in the skin, and which have the potential to imitate hematopoietic proliferations at a histological level. They include lymphoepithelioma-like carcinoma, Merkel cell carcinoma, benign lymphadenoma, pseudolymphomatous angiosarcoma, lymphadenoid dermatofibroma, lymphomatoid atypical fibroxanthoma, histiocytoid (epithelioid) hemangioma, and inflamed melanocytic lesions. The clinical and pathological features of those tumors are considered. Read More

    Mohs micrographic surgery of rare cutaneous tumours.
    J Eur Acad Dermatol Venereol 2017 Aug 24;31(8):1285-1288. Epub 2017 Jan 24.
    Department of Dermatology, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, The Netherlands.
    Background: Recurrence rates after Mohs micrographic surgery (MMS) for rare cutaneous tumours are poorly defined.

    Objective: To investigate the recurrence rate after MMS for rare cutaneous tumours at a university centre.

    Methods & Materials: Retrospective review of all rare cutaneous tumours treated with MMS at a large university centre between January 2008 and December 2012. Read More

    High prevalence of MiTF staining in undifferentiated pleomorphic sarcoma: caution in the use of melanocytic markers in sarcoma.
    Histopathology 2017 Apr 1;70(5):734-745. Epub 2017 Feb 1.
    Department of Pathology, The University of Chicago Medicine, Chicago, IL, USA.
    Aims: The diagnosis of undifferentiated pleomorphic sarcoma (UPS) may be challenging, as other lesions with undifferentiated spindle cell morphology must be excluded, including melanoma. Microphthalmia-associated transcription factor (MiTF) stains naevi and epithelioid melanomas, as well as some mesenchymal neoplasms. The aim of this study was to evaluate the prevalence of MiTF and melanocytic markers in UPS and a subset of atypical fibroxanthoma (AFX). Read More

    Lesion presenting with a "blue amber" pattern.
    World J Clin Cases 2016 Oct;4(10):333-335
    Calogero Pagliarello, Francesca Peccerillo, Alfredo Zucchi, Rocco Giuseppe Tortorella, Roberto Ricci, Ignazio Stanganelli, Claudio Feliciani, Sergio Di Nuzzo, Section of Dermatology, Department of Clinical and Experimental Medicine, University of Parma, 43100 Parma, Italy.
    Atypical fibroxanthoma (AFX) is a spindle cell neoplasm with low metastatic potential but high tendency to recur after surgery. Because of the rarity of this lesion and its aspecific clinical features, AFX could be easily misdiagnosed and undertreated by many clinicians who encounter them. Dermoscopy represents a valuable tool for easily assessing skin lesions, even though histological examination is required for final diagnosis. Read More

    Case of Pleomorphic Dermal Sarcoma of the Eyelid Treated with Micrographic Surgery and Secondary Intention Healing.
    Ann Dermatol 2016 Oct 30;28(5):632-636. Epub 2016 Sep 30.
    Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
    Pleomorphic dermal sarcoma (PDS) is a rare mesenchymal neoplasm sharing histopathological features with atypical fibroxanthoma (AFX), but has additional features of deep invasion of the superficial subcutis, tumor necrosis and vascular/perineural invasion. It is not well documented in the literature because of its rarity, and its clinical course has been debated due to the lack of homogenous criteria. We describe here the case of a 91-year-old female with a 6-month history of a solitary, asymptomatic, well-defined, 3. Read More

    Ulcerated Giant Dermatofibroma following Routine Childhood Vaccination in a Young Boy.
    Case Rep Dermatol 2016 May-Aug;8(2):210-217. Epub 2016 Aug 9.
    Dermatology Service, KK Women's and Children's Hospital, Singapore, Singapore.
    Introduction: The development of cutaneous neoplasms at immunization sites following vaccination is uncommon, and only few have been reported in the literature worldwide. We report an unusual case of an ulcerated giant dermatofibroma that developed as a chronic nonhealing plaque in the immunization scar of a young boy after vaccination.

    Case Report: A 13-month-old Chinese boy presented with an unusual skin reaction on the vaccination site at the right anterolateral thigh following a routine intramuscular injection of '5-in-1' (diphtheria, tetanus, pertussis, polio and B) vaccine at 4 months of age. Read More

    Georgian Med News 2016 Jul(256-257):11-3
    Academic Teaching Hospital Dresden-Friedrichstadt, Department of Dermatology and Allergology; Institute of Pathology "Georg Schmorl"; Department of Anesthesiology and Intensive Care Medicine, Emergency Medicine and Pain Management, Dresden, Germany.
    Cellular fibrous dermatofibroma is a rare variant of dermatofibroma/histiocytoma. We present a 61 years old female with a slow-growing, firm tumor on the sole of her right foot. The tumor was removed by slow Mohs surgery within 2 cm negative margin. Read More

    [Clinicopathologic analysis of extranodal Rosai-Dorfman disease of breast: a report of 12 cases].
    Zhonghua Bing Li Xue Za Zhi 2016 Aug;45(8):556-60
    Department of Pathology, Fujian Provincial Cancer Hospital, Teaching Hospital of Fujian Medical University, Fuzhou 350014, China.
    Objective: To investigate the clinicopathologic features, diagnosis and differential diagnosis of extranodal Rosai-Dorfman disease(RDD)of the breast.

    Methods: Twelve cases of extranodal RDD of the breast were analyzed using hematoxylin-eosin stain and immunohistochemical staining.The morphological features and immunophenotype were observed by light microscopy, accompanied with a review of the literature. Read More

    Keloidal Atypical Fibroxanthoma: Case and Review of the Literature.
    Case Rep Dermatol 2016 May-Aug;8(2):156-63. Epub 2016 Jun 6.
    University of Miami Miller School of Medicine, Miami, Fla., USA.
    Keloidal atypical fibroxanthoma (KAF) has recently been categorized as a variant of atypical fibroxanthoma. This paper will emphasize the importance of including KAF in both clinical and histological differential diagnosis of benign and malignant lesions which exhibit keloidal collagen and will also review the current literature on epidemiology, pathogenesis, histology, immunochemistry and treatments. Read More

    Clinicopathological Features of Ophthalmic Neoplasms Arising in the Setting of Xeroderma Pigmentosum.
    Ocul Oncol Pathol 2015 Dec 12;2(2):112-21. Epub 2015 Nov 12.
    Department of Pathology, Miami, Fla., USA; Sidney Kimmel Comprehensive Cancer Center, Miami, Fla., USA.
    Background: Patients with xeroderma pigmentosum (XP) are strongly predisposed to the development of numerous cutaneous cancers. However, the extent of ocular pathology in these patients has not been adequately studied.

    Methods: We conducted a retrospective study of tumors involving the ocular surface and ocular adnexa from 6 XP patients. Read More

    Atypical Fibroxanthoma of the Conjunctiva in Xeroderma Pigmentosum.
    Ocul Oncol Pathol 2015 Jun 15;1(4):254-8. Epub 2015 Apr 15.
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Fla., USA.
    Background: Atypical fibroxanthoma (AFX) is a pleomorphic tumor that most commonly presents in the elderly and arises on sun-exposed skin.

    Methods: We report a case of a 24-year-old white male with xeroderma pigmentosum (XP), who developed an AFX of the conjunctiva, and review the literature.

    Results: The patient presented with a rapidly growing conjunctival mass which was surgically excised and found to be AFX. Read More

    Nuclear factor XIIIa staining (clone AC-1A1 mouse monoclonal) is a sensitive and specific marker to discriminate sebaceous proliferations from other cutaneous clear cell neoplasms.
    J Cutan Pathol 2016 Aug 10;43(8):649-56. Epub 2016 Jun 10.
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
    Sebaceous carcinoma is a rare but serious malignancy that may be difficult to diagnose when poorly differentiated. Other epithelial tumors with clear cell change may mimic sebaceous carcinoma. Few useful or specific immunohistochemical markers for sebaceous differentiation are available. Read More

    Immunohistochemical evaluation of p16 expression in cutaneous histiocytic, fibrohistiocytic and undifferentiated lesions.
    J Cutan Pathol 2016 Aug 6;43(8):671-8. Epub 2016 Jun 6.
    Department of Dermatology, University of Michigan, Ann Arbor, MI, USA.
    Background: Expression of p16 is frequently evaluated in melanocytic lesions. Expression of p16 in cutaneous histiocytic, fibrohistiocytic and undifferentiated lesions has not been well characterized.

    Methods: We evaluated p16 expression in a cohort of histiocytic (reticulohistiocytoma, Langerhans cell histiocytosis, xanthogranuloma, Rosai Dorfman disease and xanthoma), fibrohistiocytic (dermatofibroma, epithelioid fibrous histiocytoma and dermatofibrosarcoma protuberans) and undifferentiated (atypical fibroxanthoma and pleomorphic undifferentiated sarcoma) lesions. Read More

    Correlations between clinics, dermoscopy and histopathology in a female with two dermatofibromas - a case report.
    Rom J Morphol Embryol 2016 ;57(1):323-6
    Department of Plastic and Reconstructive Microsurgery, "Bagdasar-Arseni" Emergency Hospital, Bucharest, Romania;
    Dermatofibromas are benign fibrohistiocytic tumors that involve the dermis. They have often a polymorphous clinical aspect, being frequently confused with other lesions varying from vascular tumors to melanoma. An important tool in diagnosis is represented by dermoscopy, which facilitates the recognition of dermatofibromas' characteristic structures such as central white patch and peripheral pigment network. Read More

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