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    635 results match your criteria Atypical Fibroxanthoma

    1 OF 13

    Aberrant tyrosinase expression in an atypical fibroxanthoma: A case report.
    J Cutan Pathol 2017 Jan 18. Epub 2017 Jan 18.
    Division of Dermatology, Rutgers University - New Jersey Medical School, Newark, New Jersey.
    Atypical fibroxanthoma (AFX) is a histologic mimicker of a variety of spindle cell neoplasms, and careful microscopic and immunohistochemical evaluation is critical in establishing the correct diagnosis. Here we report the histologic and immunohistochemical work up of a 1 cm nodule involving the left dorsal hand of a 66-year-old patient. Light microscopy revealed fascicles of spindled and pleomorphic cells within the dermis showing increased mitotic activity occurring in the background of sun-damaged skin. Read More

    LN2, CD10, and Ezrin Do Not Distinguish Between Atypical Fibroxanthoma and Undifferentiated Pleomorphic Sarcoma or Predict Clinical Outcome.
    Dermatol Surg 2017 Jan 10. Epub 2017 Jan 10.
    *Division of Dermatology, Department of Medicine, Vanderbilt University, Nashville, Tennessee; †Department of Dermatology, University of Oklahoma, Oklahoma City, Oklahoma; ‡Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut.
    Background: Atypical fibroxanthoma (AFX) is a rare cutaneous spindled cell neoplasm. For both diagnostic and therapeutic purposes, it is important to distinguish AFX from other poorly differentiated tumors, including undifferentiated pleomorphic sarcoma (UPS).

    Objective: The authors aimed to identify the clinical, histologic, and immunohistochemical expression of LN2, ezrin, and CD10 in AFX and UPS tumors. Read More

    Evidence-Based Medicine: Cutaneous Facial Malignancies: Nonmelanoma Skin Cancer.
    Plast Reconstr Surg 2017 Jan;139(1):181e-190e
    New York, N.Y. From the Dermatology Service and the Plastic Surgery Service, Memorial Sloan Kettering Cancer Center.
    Learning Objectives: After studying this article, the participant should be able to: 1. Identify clinical features of nonmelanoma skin cancer; 2. Distinguish low-risk versus high-risk basal cell carcinoma and squamous cell carcinoma; 3. Read More

    Incidence and Clinical Features of Rare Cutaneous Malignancies in Olmsted County, Minnesota, 2000 to 2010.
    Dermatol Surg 2017 Jan;43(1):116-124
    *Department of Dermatology, Mayo Clinic, Rochester, Minnesota;†Division of Biomedical Statistics and Informatics, Mayo Clinic Rochester, Minnesota;‡Division of Dermatologic Surgery, Mayo Clinic, Rochester, Minnesota.
    Background: The incidence of rare cutaneous malignancies is unknown. Current estimates of rare cutaneous malignancy incidences are based on broad epidemiologic data or single institution experiences, not population-based data.

    Objective: To determine the incidence of several rare nonmelanoma skin cancers. Read More

    Non-lymphoid lesions that may mimic cutaneous hematopoietic neoplasms histologically.
    Semin Diagn Pathol 2016 Nov 29. Epub 2016 Nov 29.
    From the Section of Dermatopathology, Division of Surgical Pathology & Cytopathology, University of Virginia Health System, Charlottesville, VA, USA.
    This review considers neoplastic lesions that originate in the skin, and which have the potential to imitate hematopoietic proliferations at a histological level. They include lymphoepithelioma-like carcinoma, Merkel cell carcinoma, benign lymphadenoma, pseudolymphomatous angiosarcoma, lymphadenoid dermatofibroma, lymphomatoid atypical fibroxanthoma, histiocytoid (epithelioid) hemangioma, and inflamed melanocytic lesions. The clinical and pathological features of those tumors are considered. Read More

    Mohs micrographic surgery of rare cutaneous tumours.
    J Eur Acad Dermatol Venereol 2016 Dec 15. Epub 2016 Dec 15.
    Department of Dermatology, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, The Netherlands.
    Background: Recurrence rates after Mohs micrographic surgery (MMS) for rare cutaneous tumours are poorly defined.

    Objective: To investigate the recurrence rate after MMS for rare cutaneous tumours at a university centre.

    Methods & Materials: Retrospective review of all rare cutaneous tumours treated with MMS at a large university centre between January 2008 and December 2012. Read More

    High prevalence of MiTF staining in undifferentiated pleomorphic sarcoma: caution in the use of melanocytic markers in sarcoma.
    Histopathology 2016 Dec 7. Epub 2016 Dec 7.
    Department of Pathology, The University of Chicago Medicine, Chicago, IL, USA.
    Aims: The diagnosis of undifferentiated pleomorphic sarcoma (UPS) may be challenging, as other lesions with undifferentiated spindle cell morphology must be excluded, including melanoma. Microphthalmia-associated transcription factor (MiTF) stains naevi and epithelioid melanomas, as well as some mesenchymal neoplasms. The aim of this study was to evaluate the prevalence of MiTF and melanocytic markers in UPS and a subset of atypical fibroxanthoma (AFX). Read More

    Lesion presenting with a "blue amber" pattern.
    World J Clin Cases 2016 Oct;4(10):333-335
    Calogero Pagliarello, Francesca Peccerillo, Alfredo Zucchi, Rocco Giuseppe Tortorella, Roberto Ricci, Ignazio Stanganelli, Claudio Feliciani, Sergio Di Nuzzo, Section of Dermatology, Department of Clinical and Experimental Medicine, University of Parma, 43100 Parma, Italy.
    Atypical fibroxanthoma (AFX) is a spindle cell neoplasm with low metastatic potential but high tendency to recur after surgery. Because of the rarity of this lesion and its aspecific clinical features, AFX could be easily misdiagnosed and undertreated by many clinicians who encounter them. Dermoscopy represents a valuable tool for easily assessing skin lesions, even though histological examination is required for final diagnosis. Read More

    Case of Pleomorphic Dermal Sarcoma of the Eyelid Treated with Micrographic Surgery and Secondary Intention Healing.
    Ann Dermatol 2016 Oct 30;28(5):632-636. Epub 2016 Sep 30.
    Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
    Pleomorphic dermal sarcoma (PDS) is a rare mesenchymal neoplasm sharing histopathological features with atypical fibroxanthoma (AFX), but has additional features of deep invasion of the superficial subcutis, tumor necrosis and vascular/perineural invasion. It is not well documented in the literature because of its rarity, and its clinical course has been debated due to the lack of homogenous criteria. We describe here the case of a 91-year-old female with a 6-month history of a solitary, asymptomatic, well-defined, 3. Read More

    Ulcerated Giant Dermatofibroma following Routine Childhood Vaccination in a Young Boy.
    Case Rep Dermatol 2016 May-Aug;8(2):210-217. Epub 2016 Aug 9.
    Dermatology Service, KK Women's and Children's Hospital, Singapore, Singapore.
    Introduction: The development of cutaneous neoplasms at immunization sites following vaccination is uncommon, and only few have been reported in the literature worldwide. We report an unusual case of an ulcerated giant dermatofibroma that developed as a chronic nonhealing plaque in the immunization scar of a young boy after vaccination.

    Case Report: A 13-month-old Chinese boy presented with an unusual skin reaction on the vaccination site at the right anterolateral thigh following a routine intramuscular injection of '5-in-1' (diphtheria, tetanus, pertussis, polio and Haemophilus influenzae B) vaccine at 4 months of age. Read More

    [Clinicopathologic analysis of extranodal Rosai-Dorfman disease of breast: a report of 12 cases].
    Zhonghua Bing Li Xue Za Zhi 2016 Aug;45(8):556-60
    Department of Pathology, Fujian Provincial Cancer Hospital, Teaching Hospital of Fujian Medical University, Fuzhou 350014, China.
    Objective: To investigate the clinicopathologic features, diagnosis and differential diagnosis of extranodal Rosai-Dorfman disease(RDD)of the breast.

    Methods: Twelve cases of extranodal RDD of the breast were analyzed using hematoxylin-eosin stain and immunohistochemical staining.The morphological features and immunophenotype were observed by light microscopy, accompanied with a review of the literature. Read More

    Keloidal Atypical Fibroxanthoma: Case and Review of the Literature.
    Case Rep Dermatol 2016 May-Aug;8(2):156-63. Epub 2016 Jun 6.
    University of Miami Miller School of Medicine, Miami, Fla., USA.
    Keloidal atypical fibroxanthoma (KAF) has recently been categorized as a variant of atypical fibroxanthoma. This paper will emphasize the importance of including KAF in both clinical and histological differential diagnosis of benign and malignant lesions which exhibit keloidal collagen and will also review the current literature on epidemiology, pathogenesis, histology, immunochemistry and treatments. Read More

    Clinicopathological Features of Ophthalmic Neoplasms Arising in the Setting of Xeroderma Pigmentosum.
    Ocul Oncol Pathol 2015 Dec 12;2(2):112-21. Epub 2015 Nov 12.
    Department of Pathology, Miami, Fla., USA; Sidney Kimmel Comprehensive Cancer Center, Miami, Fla., USA.
    Background: Patients with xeroderma pigmentosum (XP) are strongly predisposed to the development of numerous cutaneous cancers. However, the extent of ocular pathology in these patients has not been adequately studied.

    Methods: We conducted a retrospective study of tumors involving the ocular surface and ocular adnexa from 6 XP patients. Read More

    Atypical Fibroxanthoma of the Conjunctiva in Xeroderma Pigmentosum.
    Ocul Oncol Pathol 2015 Jun 15;1(4):254-8. Epub 2015 Apr 15.
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Fla., USA.
    Background: Atypical fibroxanthoma (AFX) is a pleomorphic tumor that most commonly presents in the elderly and arises on sun-exposed skin.

    Methods: We report a case of a 24-year-old white male with xeroderma pigmentosum (XP), who developed an AFX of the conjunctiva, and review the literature.

    Results: The patient presented with a rapidly growing conjunctival mass which was surgically excised and found to be AFX. Read More

    Nuclear factor XIIIa staining (clone AC-1A1 mouse monoclonal) is a sensitive and specific marker to discriminate sebaceous proliferations from other cutaneous clear cell neoplasms.
    J Cutan Pathol 2016 Aug 10;43(8):649-56. Epub 2016 Jun 10.
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
    Sebaceous carcinoma is a rare but serious malignancy that may be difficult to diagnose when poorly differentiated. Other epithelial tumors with clear cell change may mimic sebaceous carcinoma. Few useful or specific immunohistochemical markers for sebaceous differentiation are available. Read More

    Immunohistochemical evaluation of p16 expression in cutaneous histiocytic, fibrohistiocytic and undifferentiated lesions.
    J Cutan Pathol 2016 Aug 6;43(8):671-8. Epub 2016 Jun 6.
    Department of Dermatology, University of Michigan, Ann Arbor, MI, USA.
    Background: Expression of p16 is frequently evaluated in melanocytic lesions. Expression of p16 in cutaneous histiocytic, fibrohistiocytic and undifferentiated lesions has not been well characterized.

    Methods: We evaluated p16 expression in a cohort of histiocytic (reticulohistiocytoma, Langerhans cell histiocytosis, xanthogranuloma, Rosai Dorfman disease and xanthoma), fibrohistiocytic (dermatofibroma, epithelioid fibrous histiocytoma and dermatofibrosarcoma protuberans) and undifferentiated (atypical fibroxanthoma and pleomorphic undifferentiated sarcoma) lesions. Read More

    Atypical Fibroxanthoma in a 13-Year-Old Guatemalan Girl with Xeroderma Pigmentosum.
    Pediatr Dermatol 2016 May 4;33(3):e228-9. Epub 2016 Apr 4.
    Comprehensive Dermatology Group, Encinitas, California.
    Xeroderma pigmentosum (XP) is a rare, autosomal recessive disease involving a defect in DNA repair leading to the premature development of numerous aggressive cutaneous malignancies. Although atypical fibroxanthoma (AFX) is a neoplasm typically found in the setting of extensive sun exposure or therapeutic radiation, AFXs are rarely associated with children with XP. We report the case of a 13-year-old Guatemalan girl with the XP type C variant who developed one of the largest AFXs reported on a child's finger. Read More

    Atypical Fibroxanthoma.
    Arch Pathol Lab Med 2016 Apr;140(4):376-9
    From the Department of Pathology, University of Puerto Rico, San Juan.
    Atypical fibroxanthoma is a malignant skin tumor with histologic features similar to those of undifferentiated pleomorphic sarcoma, but lacking its more aggressive behavior. The tumor is composed of pleomorphic cells with hyperchromatic nuclei and abundant cytoplasm, commonly arranged in a spindle cell pattern. Recent genetic studies have identified similarities between atypical fibroxanthoma and undifferentiated pleomorphic sarcoma, such as the presence of 9p and 13q deletions in both tumors, favoring a common histogenesis. Read More

    Study of Epithelial to Mesenchymal Transition in Atypical Fibroxanthoma and Undifferentiated Pleomorphic Sarcoma to Discern an Epithelial Origin.
    Am J Dermatopathol 2016 Apr;38(4):270-7
    Departments of *Dermatology, and †Pathology, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain; and ‡Inflammatory and Cardiovascular Disorders Program, IMIM (Institut Hospital del Mar d'Investigacions Mèdiques), Barcelona, Spain.
    Atypical fibroxanthoma (AFX) is considered a fibroblastic or myofibroblastic neoplasm probably corresponding to a superficial variant of undifferentiated pleomorphic sarcoma (UPS). However, an epithelial origin has also been postulated. An immunohistochemical study of the epithelial to mesenchymal transition (EMT) phenomenon was performed in a series of 19 AFX and 4 UPS to discern an epithelial origin. Read More

    Clear-Cell Atypical Fibroxanthoma: A Combined Immunohistochemistry Analysis.
    Am J Dermatopathol 2016 Oct;38(10):775-9
    Department of Dermatology, University of Puerto Rico, San Juan, Puerto Rico.
    Atypical fibroxanthoma is considered to be a low-grade sarcoma, characterized by a proliferation of bizarre spindled cells. A case of a rare variant of this tumor, a clear-cell atypical fibroxanthoma, presenting with rapid growth on a 63-year-old female, is reported. The differential diagnosis of a clear cell proliferation and a review of the immunohistochemistry markers used in the diagnosis of atypical fibroxanthoma are discussed. Read More

    Clear cell atypical fibroxanthoma: a case report and review of the literature.
    J Cutan Pathol 2016 Jun 5;43(6):538-542. Epub 2016 Apr 5.
    Department of Dermatology, Kaiser Permanente, Sunset Medical Center, Los Angeles, CA, USA.
    Atypical fibroxanthoma (AFX) is a group of cutaneous tumors characterized by a population of fusiform, epithelioid and pleomorphic cells. Clinically, AFX is commonly found on the head and neck of older adults as a solitary ulcerated nodule. Clear cell atypical fibroxanthoma is a very rare variant of AFX, with only 13 cases reported to date. Read More

    Oncogene and therapeutic target analyses in atypical fibroxanthomas and pleomorphic dermal sarcomas.
    Oncotarget 2016 Apr;7(16):21763-74
    Institute of Pathology, University Hospital Cologne, Cologne, Germany.
    Background: Until now, almost nothing is known about the tumorigenesis of atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS). Our hypothesis is that AFX is the non-infiltrating precursor lesion of PDS.

    Materials And Methods: We performed the world-wide most comprehensive immunohistochemical and mutational analysis in well-defined AFX (n=5) and PDS (n=5). Read More

    Atypical fibroxanthoma in a young female misdiagnosed clinically as a malignant melanoma--An unusual presentation.
    J Cancer Res Ther 2015 Oct-Dec;11(4):1027
    Department of Pathology, Hamdard Institute of Medical Sciences and Research, New Delhi, India.
    Atypical fibroxanthoma (AFX) is an uncommon spindle cell tumor with intermediate or borderline malignant potential. Clinically, it may be misdiagnosed as a squamous cell carcinoma (SCC) or malignant melanoma. Solar irradiation has been implicated in its pathogenesis. Read More

    Clear Cell Atypical Fibroxanthoma: Clinicopathological Study of 6 Cases and Review of the Literature With Special Emphasis on the Differential Diagnosis.
    Am J Dermatopathol 2016 Aug;38(8):586-92
    *Department of Pathology, Hospital Universitario de Fuenlabrada, Madrid, Spain; †Department of Pathology, Hospital Universitario Fundación Alcorcón, Madrid, Spain; ‡Department of Pathology, Hospital Universitario de Getafe, Madrid, Spain; §Department of Pathology, Hospital Universitario 12 de Octubre, Madrid, Spain; ¶Department of Dermatology, Hospital Universitario de Fuenlabrada, Madrid, Spain; ‖Department of Pathology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain; **Department of Pathology, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain; and ††Department of Pathology, Hospital Universitario Infanta Sofía de San Sebastián de los Reyes, Madrid, Spain.
    Atypical fibroxanthoma (AFX) is an uncommon dermal-based neoplasm arising on the sun-damaged skin of elderly people. Clear cell AFX is a rare variant with only 12 cases reported until the present date, all of them as case reports, except for 1 small series of 3 cases. The authors report 6 new cases and review the literature with special emphasis on the differential diagnosis. Read More

    Reconstruction of Large Facial Defects after Delayed Mohs Surgery for Skin Cancer.
    Acta Dermatovenerol Croat 2015 ;23(4):265-9
    Prof. Uwe Wollina, MD, Department of Dermatology and Allergology, Dresden-Friedrichstadt Academic Teaching Hospital, Friedrichstrasse 41, 01067 Dresden, Germany;
    The face is a common localization for skin malignancies. Mohs surgery or delayed Mohs surgery are considered the gold standard of treatment despite new drug developments. We analyzed our patient files over a three-year period. Read More

    Histopathological Spectrum of Tumor and 
Tumor-like Lesions of the Paratestis in a 
Tertiary Care Hospital.
    Oman Med J 2015 Nov;30(6):461-8
    Pathology Department, Goa Medical College, Goa, India.
    Objectives: Tumors and tumor-like lesions (TLL) of the paratesticular region are rare. Very few studies depicting the spectrum of lesions of this location are available in the literature. Malignant neoplasms arising in the paratesticular region represent only 7. Read More

    Atypical Fibroxanthoma of the Bulbar Conjunctiva.
    Cornea 2015 Dec;34(12):1620-2
    Departments of *Ophthalmology; and †Pathology, Duke University Medical Center, Durham, NC.
    Purpose: To report a rare case of atypical fibroxanthoma (AFX) of the bulbar conjunctiva, and to compare it with previously published cases of conjunctival AFX.

    Methods: A 37-year-old woman developed a growth on the bulbar conjunctiva of her left eye that increased in size and redness over 4 months and was associated with blurry vision in the left eye, occasional diplopia, irritation of the eye, and increasing tearing. The mass was surgically excised. Read More

    Atypical Fibroxanthoma - Histological Diagnosis, Immunohistochemical Markers and Concepts of Therapy.
    Anticancer Res 2015 Nov;35(11):5717-35
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Erlangen, Erlangen, Germany
    Background: Atypical fibroxanthoma (AFX) is an uncommon, rapidly growing cutaneous neoplasm of uncertain histogenesis. Thus far, there are no guidelines for diagnosis and therapy of this tumor.

    Patients And Methods: We included 18 patients with 21 AFX, and 2,912 patients with a total of 2,939 AFX cited in the literature between 1962 and 2014. Read More

    Two friends with eroded nodules on the ears: atypical fibroxanthoma case report.
    An Bras Dermatol 2015 Jul-Aug;90(4):577-9
    Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milano, IT.
    Atypical fibroxanthoma is an uncommon mesenchymal tumor that manifests clinically as a reddish papule or nodule in sun-exposed areas of the body. The clinical presentation is not specific and histology and immunohistochemistry are both necessary for a correct diagnosis. Surgery is the gold standard of therapy. Read More

    Squamous cell carcinoma with osteoclast-like giant cells: a morphologically heterologous group including carcinosarcoma and squamous cell carcinoma with stromal changes.
    J Cutan Pathol 2016 Feb 9;43(2):148-57. Epub 2015 Sep 9.
    Department of Dermatology, University of Rochester Medical Center, Rochester, NY, USA.
    Cutaneous squamous cell carcinoma (SCC) with osteoclast-like giant cells (hereafter, osteoclastic cells) is very rare; eight cases have been reported since 2006. Whether the osteoclastic cells represents a reactive or neoplastic change remains a matter of debate. Osteoclastic cells are often observed in the sarcomatous component of cutaneous carcinosarcoma. Read More

    Pleomorphic dermal sarcoma: a more aggressive neoplasm than previously estimated.
    J Cutan Pathol 2016 Feb 29;43(2):101-12. Epub 2015 Sep 29.
    Department of Pathology, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain.
    Background: Pleomorphic dermal sarcoma (PDS) is a rare neoplasm sharing pathological features with atypical fibroxanthoma, but adding tumor necrosis, invasion beyond superficial subcutis or vascular or perineural infiltration. Although its metastatic risk has been estimated to be less than 5%, its real outcome is presently uncertain because of its rarity and to the lack of homogeneous criteria used in reported cases.

    Methods: Retrospective clinicopathological study of 18 cases of PDS. Read More

    Perineural Invasion in Atypical Fibroxanthoma of the Scalp and Forehead.
    Dermatol Surg 2015 Sep;41(9):1073-6
    Department of Dermatology, Saint Louis University School of Medicine, Saint Louis, Missouri Department of Dermatology, University of Iowa Hospitals and Clinics Iowa City, Iowa Division of Mohs Surgery & Cutaneous Oncology, Department of Dermatology, Stony Brook University Hospital Long Island, New York Dermatopathology University of Colorado Denver, Colorado California Skin Institute San Mateo, California Departments of Dermatology and Pathology, Saint Louis University School of Medicine, Saint Louis, Missouri.

    Gene fusion detection in formalin-fixed paraffin-embedded benign fibrous histiocytomas using fluorescence in situ hybridization and RNA sequencing.
    Lab Invest 2015 Sep 29;95(9):1071-6. Epub 2015 Jun 29.
    Department of Clinical Genetics, University and Regional Laboratories, Skåne University Hospital, Lund University, Lund, Sweden.
    Benign fibrous histiocytomas (FH) can be subdivided into several morphological and clinical subgroups. Recently, gene fusions involving either one of two protein kinase C genes (PRKCB and PRKCD) or the ALK gene were described in FH. We here wanted to evaluate the frequency of PRKCB and PRKCD gene fusions in FH. Read More

    Spindle Cell Atypical Fibroxanthoma: Myofibroblastic Differentiation Represents a Diagnostic Pitfall in This Variant of AFX.
    Am J Dermatopathol 2015 Jul;37(7):509-14; quiz 515-6
    *Pathology Resident (N.H.-J.), Assistant Professor and Director of Core Lab (A.M.), Professor and Chairman of Pathology (S.S.), and Associate Professor and Director of Dermatopathology (J.A.P.), Department of Pathology, Division of Dermatopathology, The Medical College of Wisconsin, Milwaukee, WI; and †Director of Dermatopathology, Hospital Obrero, La Paz, Bolivia.
    Atypical fibroxanthoma (AFX) is a low-grade, dermal, mesenchymal neoplasm, which lacks a specific lineage of differentiation. The classical histologic appearance of AFX is that of a pleomorphic and spindle cell neoplasm with marked nuclear pleomorphism, mitotic figures, and often prominent storiform pattern that superficially resembles a pleomorphic high-grade sarcoma ("malignant fibrous histiocytoma"). Many histologic variants have been described. Read More

    Recurrent Atypical Fibroxanthoma Versus Malignant Fibrous Histiocytoma.
    J Craniofac Surg 2015 Jun;26(4):e322-3
    *Department of Plastic and Reconstructive Surgery, Wake Forest Baptist Health, Winston-Salem †The Skin Surgery Center, Winston-Salem, NC.
    Atypical fibroxanthoma (AFX) has been characterized variously as a benign noninvasive neoplasm with rare recurrence. We report 2 cases of recurrent AFX. There is ongoing controversy over the diagnosis of AFX versus malignant fibrous histiocytoma (MFH) in the clinical context of recurrent AFX. Read More

    Pleomorphic spindle cell dermal neoplasm with dot-like keratin reactivity: keratin-positive AFX or carcinoma?
    J Cutan Pathol 2015 Nov 14;42(11):847-52. Epub 2015 Jul 14.
    Department of Pathology and Laboratory Medicine Division of Dermatology, University of Kansas School of Medicine, Kansas City, KS, USA.
    Atypical fibroxanthoma (AFX) is an uncommon cutaneous neoplasm of pleomorphic myofibroblast-like cells. Diagnosis requires exclusion of other undifferentiated spindle and pleomorphic cell neoplasms by immunohistochemistry. We report two patients with p63-non-reactive spindle cell neoplasms which resembled AFX but demonstrated anomalous dot-like immunolabeling with antibodies to high molecular weight keratin and keratin 5. Read More

    Atypical Fibroxanthoma: A case series and review of literature.
    Auris Nasus Larynx 2015 Dec 22;42(6):469-71. Epub 2015 Apr 22.
    Epsom and St Helier University Hospitals NHS Trust, Wrythe Lane, Carshalton SM5 1AA, United Kingdom.
    Intro/objective: Atypical Fibroxanthoma (AFX) is a rare cutaneous neoplasm arising from myofibroblast or fibroblast-like cells that predominantly affects the head and neck region. It commonly mimics more invasive neoplasms and is a diagnostic challenge to clinicians. The aim of this study was to develop a better understanding of AFX, focusing on recent developments in diagnosis and management. Read More

    Malignant cutaneous adnexal tumours of the head and neck: an update on management.
    Br J Oral Maxillofac Surg 2015 Jul 22;53(6):485-90. Epub 2015 Apr 22.
    Department of Oral & Maxillofacial Surgery, Queen Alexandra Hospital, Portsmouth, UK. Electronic address:
    Adnexal tumours form a heterogeneous group of relatively rare neoplasms. Many of them have a poor prognosis and treatment can sometimes be difficult and controversial. We summarise the latest publications relating to malignant cutaneous adnexal tumours of the head and neck, and give an update on their management. Read More

    ALK rearrangement and overexpression in epithelioid fibrous histiocytoma.
    Mod Pathol 2015 Jul 10;28(7):904-12. Epub 2015 Apr 10.
    Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
    Epithelioid benign fibrous histiocytoma, also known as 'epithelioid cell histiocytoma,' has traditionally been considered a morphologic variant of cutaneous fibrous histiocytoma (dermatofibroma). In addition to its characteristic epithelioid cytomorphology, several phenotypic differences suggest that epithelioid fibrous histiocytoma may differ biologically from other variants. Recently, ALK rearrangement was described in two cases of epithelioid fibrous histiocytoma and separately in two cases reported as 'atypical' fibrous histiocytoma (with epithelioid features), with corresponding ALK expression detectable by immunohistochemistry. Read More

    Atypical fibroxanthoma†.
    J Surg Case Rep 2015 Mar 4;2015(3). Epub 2015 Mar 4.
    Department of Surgery, Universidade Federal do Rio Grande - FURG, Rio Grande, RS, Brazil.
    Atypical fibroxanthoma (AFX) is a rare skin neoplasm of low-grade malignancy and fibroblastic origin. AFX is a curable cutaneous disease and the diagnosis depends on knowledge of its clinical and histological features and combined immunohistochemistry markers. This study presents a case of a male patient, aged 90 years, presented with painless skin lesion in his ear. Read More

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