J Dtsch Dermatol Ges 2017 Jun;15(6):630-648

Department of Dermatology and Allergology, Munich Technical University, Munich, Germany.

Cutaneous sarcomas comprise a heterogeneous group of mesenchymal spindle cell tumors of the dermis and subcutis, one of the best-known entities being dermatofibrosarcoma protuberans. Other sarcomas addressed in this review include atypical fibroxanthoma, cutaneous undifferentiated pleomorphic sarcoma, leiomyosarcoma, liposarcoma, and angiosarcoma. With the exception of dermatofibrosarcoma protuberans, which has its peak incidence in middle-aged adults, cutaneous sarcomas usually occur in elderly individuals starting in the sixth or seventh decade of life. Read More

J Contemp Brachytherapy 2017 Apr 25;9(2):158-160. Epub 2017 Jan 25.

DermaHealth Dermatology & Dermasurgery, Richland, WA, USA.

Purpose: To evaluate the suitability of treating atypical fibroxanthoma (AFX), an uncommon skin malignancy, with electronic brachytherapy.

Material And Methods: From Feb 2013 to Sep 2014, we were referred a total of 8 cases of AFX in 7 patients, all involving the scalp. All of them were treated with electronic brachytherapy 50 Kev radiations (Xoft Axxent(®), Fremont, California). Read More

Surg Pathol Clin 2017 Jun 14;10(2):319-335. Epub 2017 Mar 14.

Department of Pathology, University of Edinburgh, United Kingdom.

Atypical fibroxanthoma (AFX) represents a rare mesenchymal neoplasm arising predominantly in the head and neck area of elderly patients. Clinically, the neoplasm is characterized by a rapid and exophytic growth with frequent ulceration of the epidermis. Histopathologically, AFX represents a well-circumscribed, dermal-based neoplasm composed of a variable admixture of large histiocytoid cells, enlarged spindled and epithelioid tumor cells, and multinucleated tumor giant cells with bizarre and pleomorphic nuclei. Read More

Australas J Dermatol 2017 May;58(2):150-151

Princess Alexandra Hospital, Brisbane, Queensland,, Australia.

Int J Trichology 2016 Oct-Dec;8(4):191-194

Department of Pathology, S Nijalingappa Medical College, Bagalkot, Karnataka, India.

Squamous cell carcinoma (SCC) is the second most cutaneous malignancy after basal cell carcinoma (BCC) with increasing incidence. In the view its nodular manifestation; it can appear similar to nodular BCC, atypical fibroxanthoma, sclerosing liposarcoma and desmoplastic melanoma. Prognostic and therapeutic implications are different in all these conditions and thus their distinction becomes important. Read More

J Dermatol 2017 Mar;44(3):251-258

Boston University School of Medicine, Boston, Massachusetts, USA.

Since the initial description of the granular cell tumor in 1926, numerous other neoplasms, both benign and malignant, have been described to exhibit granular cell change. In most cases, diagnosis remains straightforward via recognition of retained histopathological morphology of the archetypal tumor, despite the presence of focal granular appearance. However, tumors with granular cell differentiation can present a diagnostic challenge either by mimicking alternative diagnoses, or by failing to exhibit architectural clues of the primary entity, thus requiring an immunohistochemical work-up. Read More

Am J Dermatopathol 2017 Feb 2. Epub 2017 Feb 2.

*Service of Dermatology, Hospital Central do Funchal, Funchal, Portugal†Service of Dermatology, Centro Médico-Cirúrgico Lisboa, Lisboa, Portugal.

Pol J Pathol 2016;67(3):291-294

The Fingerland Department of Pathology, Charles University in Prague, Faculty of Medicine and University Hospital in Hradec Králové, Czech Republic.

Dermatofibroma-like granular cell tumour (GCT) is a rare entity, with only two cases having been described so far. We report another case in a 62-year-old woman, discuss histopathological features, and review other tumours in which granular changes have been observed. Our tumour was composed predominantly of oval-to-spindle granular cells with prominent nucleoli, arranged in short fascicles and storiform pattern, infiltrating around collagen bundles. Read More

J Cutan Pathol 2017 May 16;44(5):467-469. Epub 2017 Feb 16.

Division of Dermatology, Rutgers University - New Jersey Medical School, Newark, New Jersey.

Atypical fibroxanthoma (AFX) is a histologic mimicker of a variety of spindle cell neoplasms, and careful microscopic and immunohistochemical evaluation is critical in establishing the correct diagnosis. Here we report the histologic and immunohistochemical work up of a 1 cm nodule involving the left dorsal hand of a 66-year-old patient. Light microscopy revealed fascicles of spindled and pleomorphic cells within the dermis showing increased mitotic activity occurring in the background of sun-damaged skin. Read More

Dermatol Surg 2017 Mar;43(3):431-436

*Division of Dermatology, Department of Medicine, Vanderbilt University, Nashville, Tennessee; †Department of Dermatology, University of Oklahoma, Oklahoma City, Oklahoma; ‡Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut.

Background: Atypical fibroxanthoma (AFX) is a rare cutaneous spindled cell neoplasm. For both diagnostic and therapeutic purposes, it is important to distinguish AFX from other poorly differentiated tumors, including undifferentiated pleomorphic sarcoma (UPS).

Objective: The authors aimed to identify the clinical, histologic, and immunohistochemical expression of LN2, ezrin, and CD10 in AFX and UPS tumors. Read More

Plast Reconstr Surg 2017 Jan;139(1):181e-190e

New York, N.Y. From the Dermatology Service and the Plastic Surgery Service, Memorial Sloan Kettering Cancer Center.

Learning Objectives: After studying this article, the participant should be able to: 1. Identify clinical features of nonmelanoma skin cancer; 2. Distinguish low-risk versus high-risk basal cell carcinoma and squamous cell carcinoma; 3. Read More

Dermatol Surg 2017 Jan;43(1):116-124

*Department of Dermatology, Mayo Clinic, Rochester, Minnesota;†Division of Biomedical Statistics and Informatics, Mayo Clinic Rochester, Minnesota;‡Division of Dermatologic Surgery, Mayo Clinic, Rochester, Minnesota.

Background: The incidence of rare cutaneous malignancies is unknown. Current estimates of rare cutaneous malignancy incidences are based on broad epidemiologic data or single institution experiences, not population-based data.

Objective: To determine the incidence of several rare nonmelanoma skin cancers. Read More

JAAD Case Rep 2016 Nov 7;2(6):491-493. Epub 2016 Dec 7.

University of Central Florida, College of Medicine, Orlando, Florida.

JAAD Case Rep 2016 Nov 5;2(6):445-447. Epub 2016 Dec 5.

Melanoma and Cutaneous Oncology Program, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah; Intermountain Health Care, Salt Lake City, Utah.

Semin Diagn Pathol 2017 Jan 29;34(1):99-107. Epub 2016 Nov 29.

From the Section of Dermatopathology, Division of Surgical Pathology & Cytopathology, University of Virginia Health System, Charlottesville, VA, USA.

This review considers neoplastic lesions that originate in the skin, and which have the potential to imitate hematopoietic proliferations at a histological level. They include lymphoepithelioma-like carcinoma, Merkel cell carcinoma, benign lymphadenoma, pseudolymphomatous angiosarcoma, lymphadenoid dermatofibroma, lymphomatoid atypical fibroxanthoma, histiocytoid (epithelioid) hemangioma, and inflamed melanocytic lesions. The clinical and pathological features of those tumors are considered. Read More

J Eur Acad Dermatol Venereol 2016 Dec 15. Epub 2016 Dec 15.

Department of Dermatology, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, The Netherlands.

Background: Recurrence rates after Mohs micrographic surgery (MMS) for rare cutaneous tumours are poorly defined.

Objective: To investigate the recurrence rate after MMS for rare cutaneous tumours at a university centre.

Methods & Materials: Retrospective review of all rare cutaneous tumours treated with MMS at a large university centre between January 2008 and December 2012. Read More

Histopathology 2017 Apr 1;70(5):734-745. Epub 2017 Feb 1.

Department of Pathology, The University of Chicago Medicine, Chicago, IL, USA.

Aims: The diagnosis of undifferentiated pleomorphic sarcoma (UPS) may be challenging, as other lesions with undifferentiated spindle cell morphology must be excluded, including melanoma. Microphthalmia-associated transcription factor (MiTF) stains naevi and epithelioid melanomas, as well as some mesenchymal neoplasms. The aim of this study was to evaluate the prevalence of MiTF and melanocytic markers in UPS and a subset of atypical fibroxanthoma (AFX). Read More

World J Clin Cases 2016 Oct;4(10):333-335

Calogero Pagliarello, Francesca Peccerillo, Alfredo Zucchi, Rocco Giuseppe Tortorella, Roberto Ricci, Ignazio Stanganelli, Claudio Feliciani, Sergio Di Nuzzo, Section of Dermatology, Department of Clinical and Experimental Medicine, University of Parma, 43100 Parma, Italy.

Atypical fibroxanthoma (AFX) is a spindle cell neoplasm with low metastatic potential but high tendency to recur after surgery. Because of the rarity of this lesion and its aspecific clinical features, AFX could be easily misdiagnosed and undertreated by many clinicians who encounter them. Dermoscopy represents a valuable tool for easily assessing skin lesions, even though histological examination is required for final diagnosis. Read More

Ann Dermatol 2016 Oct 30;28(5):632-636. Epub 2016 Sep 30.

Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

Pleomorphic dermal sarcoma (PDS) is a rare mesenchymal neoplasm sharing histopathological features with atypical fibroxanthoma (AFX), but has additional features of deep invasion of the superficial subcutis, tumor necrosis and vascular/perineural invasion. It is not well documented in the literature because of its rarity, and its clinical course has been debated due to the lack of homogenous criteria. We describe here the case of a 91-year-old female with a 6-month history of a solitary, asymptomatic, well-defined, 3. Read More

Case Rep Dermatol 2016 May-Aug;8(2):210-217. Epub 2016 Aug 9.

Dermatology Service, KK Women's and Children's Hospital, Singapore, Singapore.

Introduction: The development of cutaneous neoplasms at immunization sites following vaccination is uncommon, and only few have been reported in the literature worldwide. We report an unusual case of an ulcerated giant dermatofibroma that developed as a chronic nonhealing plaque in the immunization scar of a young boy after vaccination.

Case Report: A 13-month-old Chinese boy presented with an unusual skin reaction on the vaccination site at the right anterolateral thigh following a routine intramuscular injection of '5-in-1' (diphtheria, tetanus, pertussis, polio and Haemophilus influenzae B) vaccine at 4 months of age. Read More

Georgian Med News 2016 Jul(256-257):11-3

Academic Teaching Hospital Dresden-Friedrichstadt, Department of Dermatology and Allergology; Institute of Pathology "Georg Schmorl"; Department of Anesthesiology and Intensive Care Medicine, Emergency Medicine and Pain Management, Dresden, Germany.

Cellular fibrous dermatofibroma is a rare variant of dermatofibroma/histiocytoma. We present a 61 years old female with a slow-growing, firm tumor on the sole of her right foot. The tumor was removed by slow Mohs surgery within 2 cm negative margin. Read More

Zhonghua Bing Li Xue Za Zhi 2016 Aug;45(8):556-60

Department of Pathology, Fujian Provincial Cancer Hospital, Teaching Hospital of Fujian Medical University, Fuzhou 350014, China.

Objective: To investigate the clinicopathologic features, diagnosis and differential diagnosis of extranodal Rosai-Dorfman disease(RDD)of the breast.

Methods: Twelve cases of extranodal RDD of the breast were analyzed using hematoxylin-eosin stain and immunohistochemical staining.The morphological features and immunophenotype were observed by light microscopy, accompanied with a review of the literature. Read More

Case Rep Dermatol 2016 May-Aug;8(2):156-63. Epub 2016 Jun 6.

University of Miami Miller School of Medicine, Miami, Fla., USA.

Keloidal atypical fibroxanthoma (KAF) has recently been categorized as a variant of atypical fibroxanthoma. This paper will emphasize the importance of including KAF in both clinical and histological differential diagnosis of benign and malignant lesions which exhibit keloidal collagen and will also review the current literature on epidemiology, pathogenesis, histology, immunochemistry and treatments. Read More

Dermatol Surg 2017 Jan;43(1):138-139

Department of Dermatology, University of Colorado School of Medicine, Aurora, Colorado.

Ocul Oncol Pathol 2015 Dec 12;2(2):112-21. Epub 2015 Nov 12.

Department of Pathology, Miami, Fla., USA; Sidney Kimmel Comprehensive Cancer Center, Miami, Fla., USA.

Background: Patients with xeroderma pigmentosum (XP) are strongly predisposed to the development of numerous cutaneous cancers. However, the extent of ocular pathology in these patients has not been adequately studied.

Methods: We conducted a retrospective study of tumors involving the ocular surface and ocular adnexa from 6 XP patients. Read More

Ocul Oncol Pathol 2015 Jun 15;1(4):254-8. Epub 2015 Apr 15.

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Fla., USA.

Background: Atypical fibroxanthoma (AFX) is a pleomorphic tumor that most commonly presents in the elderly and arises on sun-exposed skin.

Methods: We report a case of a 24-year-old white male with xeroderma pigmentosum (XP), who developed an AFX of the conjunctiva, and review the literature.

Results: The patient presented with a rapidly growing conjunctival mass which was surgically excised and found to be AFX. Read More

J Cutan Pathol 2016 Aug 10;43(8):649-56. Epub 2016 Jun 10.

Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Sebaceous carcinoma is a rare but serious malignancy that may be difficult to diagnose when poorly differentiated. Other epithelial tumors with clear cell change may mimic sebaceous carcinoma. Few useful or specific immunohistochemical markers for sebaceous differentiation are available. Read More

J Cutan Pathol 2016 Aug 6;43(8):671-8. Epub 2016 Jun 6.

Department of Dermatology, University of Michigan, Ann Arbor, MI, USA.

Background: Expression of p16 is frequently evaluated in melanocytic lesions. Expression of p16 in cutaneous histiocytic, fibrohistiocytic and undifferentiated lesions has not been well characterized.

Methods: We evaluated p16 expression in a cohort of histiocytic (reticulohistiocytoma, Langerhans cell histiocytosis, xanthogranuloma, Rosai Dorfman disease and xanthoma), fibrohistiocytic (dermatofibroma, epithelioid fibrous histiocytoma and dermatofibrosarcoma protuberans) and undifferentiated (atypical fibroxanthoma and pleomorphic undifferentiated sarcoma) lesions. Read More

Rom J Morphol Embryol 2016 ;57(1):323-6

Department of Plastic and Reconstructive Microsurgery, "Bagdasar-Arseni" Emergency Hospital, Bucharest, Romania;

Dermatofibromas are benign fibrohistiocytic tumors that involve the dermis. They have often a polymorphous clinical aspect, being frequently confused with other lesions varying from vascular tumors to melanoma. An important tool in diagnosis is represented by dermoscopy, which facilitates the recognition of dermatofibromas' characteristic structures such as central white patch and peripheral pigment network. Read More

JAAD Case Rep 2015 Nov 2;1(6):392-4. Epub 2015 Nov 2.

Department of Dermatology, University of Colorado School of Medicine, Aurora, Colorado.

Pediatr Dermatol 2016 May 4;33(3):e228-9. Epub 2016 Apr 4.

Comprehensive Dermatology Group, Encinitas, California.

Xeroderma pigmentosum (XP) is a rare, autosomal recessive disease involving a defect in DNA repair leading to the premature development of numerous aggressive cutaneous malignancies. Although atypical fibroxanthoma (AFX) is a neoplasm typically found in the setting of extensive sun exposure or therapeutic radiation, AFXs are rarely associated with children with XP. We report the case of a 13-year-old Guatemalan girl with the XP type C variant who developed one of the largest AFXs reported on a child's finger. Read More

Arch Pathol Lab Med 2016 Apr;140(4):376-9

From the Department of Pathology, University of Puerto Rico, San Juan.

Atypical fibroxanthoma is a malignant skin tumor with histologic features similar to those of undifferentiated pleomorphic sarcoma, but lacking its more aggressive behavior. The tumor is composed of pleomorphic cells with hyperchromatic nuclei and abundant cytoplasm, commonly arranged in a spindle cell pattern. Recent genetic studies have identified similarities between atypical fibroxanthoma and undifferentiated pleomorphic sarcoma, such as the presence of 9p and 13q deletions in both tumors, favoring a common histogenesis. Read More

Am J Dermatopathol 2016 Apr;38(4):270-7

Departments of *Dermatology, and †Pathology, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain; and ‡Inflammatory and Cardiovascular Disorders Program, IMIM (Institut Hospital del Mar d'Investigacions Mèdiques), Barcelona, Spain.

Atypical fibroxanthoma (AFX) is considered a fibroblastic or myofibroblastic neoplasm probably corresponding to a superficial variant of undifferentiated pleomorphic sarcoma (UPS). However, an epithelial origin has also been postulated. An immunohistochemical study of the epithelial to mesenchymal transition (EMT) phenomenon was performed in a series of 19 AFX and 4 UPS to discern an epithelial origin. Read More

Am J Dermatopathol 2016 Oct;38(10):775-9

Department of Dermatology, University of Puerto Rico, San Juan, Puerto Rico.

Atypical fibroxanthoma is considered to be a low-grade sarcoma, characterized by a proliferation of bizarre spindled cells. A case of a rare variant of this tumor, a clear-cell atypical fibroxanthoma, presenting with rapid growth on a 63-year-old female, is reported. The differential diagnosis of a clear cell proliferation and a review of the immunohistochemistry markers used in the diagnosis of atypical fibroxanthoma are discussed. Read More

J Cutan Pathol 2016 Jun 5;43(6):538-542. Epub 2016 Apr 5.

Department of Dermatology, Kaiser Permanente, Sunset Medical Center, Los Angeles, CA, USA.

Atypical fibroxanthoma (AFX) is a group of cutaneous tumors characterized by a population of fusiform, epithelioid and pleomorphic cells. Clinically, AFX is commonly found on the head and neck of older adults as a solitary ulcerated nodule. Clear cell atypical fibroxanthoma is a very rare variant of AFX, with only 13 cases reported to date. Read More

Oncotarget 2016 Apr;7(16):21763-74

Institute of Pathology, University Hospital Cologne, Cologne, Germany.

Background: Until now, almost nothing is known about the tumorigenesis of atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS). Our hypothesis is that AFX is the non-infiltrating precursor lesion of PDS.

Materials And Methods: We performed the world-wide most comprehensive immunohistochemical and mutational analysis in well-defined AFX (n=5) and PDS (n=5). Read More

J Cancer Res Ther 2015 Oct-Dec;11(4):1027

Department of Pathology, Hamdard Institute of Medical Sciences and Research, New Delhi, India.

Atypical fibroxanthoma (AFX) is an uncommon spindle cell tumor with intermediate or borderline malignant potential. Clinically, it may be misdiagnosed as a squamous cell carcinoma (SCC) or malignant melanoma. Solar irradiation has been implicated in its pathogenesis. Read More

Am J Dermatopathol 2016 Aug;38(8):586-92

*Department of Pathology, Hospital Universitario de Fuenlabrada, Madrid, Spain; †Department of Pathology, Hospital Universitario Fundación Alcorcón, Madrid, Spain; ‡Department of Pathology, Hospital Universitario de Getafe, Madrid, Spain; §Department of Pathology, Hospital Universitario 12 de Octubre, Madrid, Spain; ¶Department of Dermatology, Hospital Universitario de Fuenlabrada, Madrid, Spain; ‖Department of Pathology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain; **Department of Pathology, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain; and ††Department of Pathology, Hospital Universitario Infanta Sofía de San Sebastián de los Reyes, Madrid, Spain.

Atypical fibroxanthoma (AFX) is an uncommon dermal-based neoplasm arising on the sun-damaged skin of elderly people. Clear cell AFX is a rare variant with only 12 cases reported until the present date, all of them as case reports, except for 1 small series of 3 cases. The authors report 6 new cases and review the literature with special emphasis on the differential diagnosis. Read More

Am J Dermatopathol 2016 02;38(2):165-6

*Dermatopathology Division, Pathlab Bay of Plenty, Tauranga, New Zealand †Skin at Da Vinci Clinic, Tauranga, New Zealand ‡Clinipath Pathology, West Perth, Australia.

J Clin Diagn Res 2015 Dec 1;9(12):EL02-3. Epub 2015 Dec 1.

Associate Consultant, Department of Pathology and Laboratory Medicine, Medanta- the Medicity , Sector 38, Gurgaon, Haryana. India .

Acta Dermatovenerol Croat 2015 ;23(4):265-9

Prof. Uwe Wollina, MD, Department of Dermatology and Allergology, Dresden-Friedrichstadt Academic Teaching Hospital, Friedrichstrasse 41, 01067 Dresden, Germany;

The face is a common localization for skin malignancies. Mohs surgery or delayed Mohs surgery are considered the gold standard of treatment despite new drug developments. We analyzed our patient files over a three-year period. Read More

J Dermatol 2016 May 24;43(5):582-3. Epub 2015 Dec 24.

Department of Dermatology, School of Medicine, Kyung Hee University, Seoul, Korea.

Eur J Dermatol 2015 Sep-Oct;25(5):520-1

Department of Dermatology, Venereology and Allergology, University Hospital Wuerzburg, Josef-Schneider-Str. 2, 97080 Wuerzburg, Germany.

Oman Med J 2015 Nov;30(6):461-8

Pathology Department, Goa Medical College, Goa, India.

Objectives: Tumors and tumor-like lesions (TLL) of the paratesticular region are rare. Very few studies depicting the spectrum of lesions of this location are available in the literature. Malignant neoplasms arising in the paratesticular region represent only 7. Read More

Arch Plast Surg 2015 Nov 16;42(6):803-5. Epub 2015 Nov 16.

Plastic, Reconstructive and Aesthetics Surgery Clinic, Ankara Research and Training Hospital, Ankara, Turkey.

Cornea 2015 Dec;34(12):1620-2

Departments of *Ophthalmology; and †Pathology, Duke University Medical Center, Durham, NC.

Purpose: To report a rare case of atypical fibroxanthoma (AFX) of the bulbar conjunctiva, and to compare it with previously published cases of conjunctival AFX.

Methods: A 37-year-old woman developed a growth on the bulbar conjunctiva of her left eye that increased in size and redness over 4 months and was associated with blurry vision in the left eye, occasional diplopia, irritation of the eye, and increasing tearing. The mass was surgically excised. Read More

Anticancer Res 2015 Nov;35(11):5717-35

Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Erlangen, Erlangen, Germany

Background: Atypical fibroxanthoma (AFX) is an uncommon, rapidly growing cutaneous neoplasm of uncertain histogenesis. Thus far, there are no guidelines for diagnosis and therapy of this tumor.

Patients And Methods: We included 18 patients with 21 AFX, and 2,912 patients with a total of 2,939 AFX cited in the literature between 1962 and 2014. Read More

An Bras Dermatol 2015 Jul-Aug;90(4):577-9

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milano, IT.

Atypical fibroxanthoma is an uncommon mesenchymal tumor that manifests clinically as a reddish papule or nodule in sun-exposed areas of the body. The clinical presentation is not specific and histology and immunohistochemistry are both necessary for a correct diagnosis. Surgery is the gold standard of therapy. Read More

J Cutan Pathol 2016 Feb 9;43(2):148-57. Epub 2015 Sep 9.

Department of Dermatology, University of Rochester Medical Center, Rochester, NY, USA.

Cutaneous squamous cell carcinoma (SCC) with osteoclast-like giant cells (hereafter, osteoclastic cells) is very rare; eight cases have been reported since 2006. Whether the osteoclastic cells represents a reactive or neoplastic change remains a matter of debate. Osteoclastic cells are often observed in the sarcomatous component of cutaneous carcinosarcoma. Read More

J Cutan Pathol 2016 Feb 29;43(2):101-12. Epub 2015 Sep 29.

Department of Pathology, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain.

Background: Pleomorphic dermal sarcoma (PDS) is a rare neoplasm sharing pathological features with atypical fibroxanthoma, but adding tumor necrosis, invasion beyond superficial subcutis or vascular or perineural infiltration. Although its metastatic risk has been estimated to be less than 5%, its real outcome is presently uncertain because of its rarity and to the lack of homogeneous criteria used in reported cases.

Methods: Retrospective clinicopathological study of 18 cases of PDS. Read More