672 results match your criteria Atypical Fibroxanthoma


Naturopathic Self-Treatment of an Atypical Fibroxanthoma: Lessons for Dermatologic Surgery.

J Drugs Dermatol 2018 Jun;17(6):683-685

Background: Alternative therapies are favored by some patients. In skin cancer, this may be to try to avoid surgery out of fear for the procedure and its functional or cosmetic consequences. Frequently, use of these therapies is not curative and can cause harm. Read More

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Microphthalmia-associated transcription factor (MiTF): Promiscuous staining patterns in fibrohistiocytic lesions is a potential pitfall.

Pathol Res Pract 2018 Jun 11;214(6):821-825. Epub 2018 May 11.

Department of Pathology & Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Electronic address:

Microphthalmia-associated transcription factor (MiTF) is used as a marker of melanocytic differentiation. However, MiTF immunoexpression has also been observed in histiocytes, macrophages, smooth muscle cells and fibroblasts, which raise the concern of fibrohistiocytic (FH) lesions being misdiagnosed as melanoma based on MiTF immunoreactivity. MiTF has been known to be positive in FH tumors, but this is the first study evaluating ninety-three fibrohistiocytic neoplasms to understand and delineate the staining pattern of MiTF in these tumors. Read More

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June 2018
3 Reads
1.56 Impact Factor

Atypical Fibroxanthoma of the Bulbar Conjunctiva: A Unique Case Describing the Pathology, Clinical Presentation, and Management.

Ocul Oncol Pathol 2018 Apr 20;4(3):152-156. Epub 2017 Oct 20.

The Ohio State University Department of Ophthalmology, Columbus, OH, USA.

Background/aims: Atypical fibroxanthoma is an uncommon tumor that usually occurs in the skin of the head and neck of the elderly with significant sun exposure. We describe a unique case featuring a rare ocular surface conjunctival tumor (atypical fibroxanthoma) and provide insight on its characteristic clinical features, surgical management, and histology.

Methods: A 71-year-old male fisherman with no pertinent ocular history presented to an academic center with a rapidly enlarging bulbar conjunctival mass in the right perilimbal region for the past several months. Read More

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April 2018
1 Read

gene amplification is a rare event in atypical fibroxanthoma and pleomorphic dermal sarcoma.

Oncotarget 2018 Apr 20;9(30):21182-21189. Epub 2018 Apr 20.

Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Germany.

Atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS) are rare malignancies typically occurring in elderly patients and predominantly located in skin regions exposed to UV-light. Thus, a role of UV-radiation-induced damage for AFX and PDS tumorigenesis has been postulated. gene amplification has been demonstrated as a distinctive feature of radiation-induced angiosarcoma. Read More

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Dermoscopic rainbow pattern: A clue to diagnosing aneurysmal atypical fibroxanthoma.

JAAD Case Rep 2018 May 31;4(4):292-294. Epub 2018 Mar 31.

Department of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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May 2018
1 Read

A tale of two clones: Caldesmon staining in the differentiation of cutaneous spindle cell neoplasms.

J Cutan Pathol 2018 Apr 17. Epub 2018 Apr 17.

Division of Dermatology, Washington University School of Medicine, Saint Louis, Missouri.

Background: We sought to compare the sensitivity and specificity of 2 different caldesmon antibodies in differentiating leiomyosarcoma from other cutaneous spindle cell neoplasms.

Methods: Representative cutaneous spindle cell neoplasms were identified, including leiomyosarcoma, atypical fibroxanthoma, dermatomyofibroma and spindle cell squamous cell carcinoma. Immunohistochemistry was performed with antibodies directed toward caldesmon, smooth-muscle actin (SMA) and desmin. Read More

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Metastatic melanoma with balloon/histiocytoid cytomorphology after treatment with immunotherapy: A histologic mimic and diagnostic pitfall.

J Cutan Pathol 2018 Jul 18;45(7):545-549. Epub 2018 May 18.

Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, Texas.

Epithelioid cells with foamy cytoplasm (histiocytoid features) are typical histopathologic findings among benign and malignant histiocytic neoplasms such as xanthoma and atypical fibroxanthoma. However, these changes are unusual in melanoma, which is typically composed of nested and variably pigmented atypical epithelioid cells. Here, we report a patient with metastatic melanoma in lymph nodes presenting with prominent balloon cell/histiocytoid features expressing melanocytic markers, after treatment with nivolumab. Read More

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July 2018
4 Reads

An Unusual Case of Pinna Squamous Cell Carcinoma Arising Shortly after Resection of Atypical Fibroxanthoma.

Case Rep Otolaryngol 2018 23;2018:6092169. Epub 2018 Jan 23.

Department of Histopathology, Calderdale Royal Hospital, Halifax, UK.

Objective: To report a unique case of pinna squamous cell carcinoma (SCC) arising shortly after resection of atypical fibroxanthoma (AFX) at the same site.

Case Report: An 81-year-old gentleman presented with a nodular right pinna lesion. This was excised, and histology confirmed AFX. Read More

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January 2018

Dermoscopy features of atypical fibroxanthoma: A multicenter study of the International Dermoscopy Society.

Australas J Dermatol 2018 Mar 23. Epub 2018 Mar 23.

Dermatology Unit, University of Campania Luigi Vanvitelli, Naples, Italy.

Background/objectives: Little is known about the dermoscopic features of atypical fibroxanthoma.

Methods: This was a case-control study. Atypical fibroxanthoma lesions were compared with a control group with non-melanoma skin cancer. Read More

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March 2018
3 Reads

Atypical fibroxanthoma with prominent CD8-positive lymphocytic infiltration and diffuse expression of epithelial membrane antigen.

J Dtsch Dermatol Ges 2018 Mar 29;16(3):330-332. Epub 2018 Jan 29.

Department of Dermatology, Kawasaki Municipal Hospital, Kawasaki, Japan.

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March 2018
4 Reads
1.82 Impact Factor

h-caldesmon immunoreactivity in atypical fibroxanthoma: implications for the differential diagnosis.

Pathology 2018 Apr 1;50(3):358-361. Epub 2018 Mar 1.

Biomedical Research Institute INCLIVA, Valencia, Spain; Department of Pathology, Hospital Clínico Universitario de Valencia, Valencia, Spain; University of Valencia, Valencia, Spain. Electronic address:

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April 2018
2 Reads

Copy number variations in atypical fibroxanthomas and pleomorphic dermal sarcomas.

Oncotarget 2017 Dec 25;8(65):109457-109467. Epub 2017 Nov 25.

Institute of Pathology, University Hospital Cologne, Cologne, Germany.

Atypical fibroxanthomas (AFX) and pleomorphic dermal sarcomas (PDS) are frequent cutaneous sarcomas typically arising on sun-exposed skin in elderly patients. In contrast to AFX, which generally do not recur after complete excision, PDS locally recur in up to 50% and metastasize in up to 20%. We recently detected characteristic UV-induced mutations as potential driver mutation in almost all PDS investigated as well as activating and gene mutations in around one third of our tumors representing targets for personalized treatments in patients with unresectable or metastasized PDS. Read More

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December 2017
2 Reads

Genomic analysis of atypical fibroxanthoma.

PLoS One 2017 15;12(11):e0188272. Epub 2017 Nov 15.

Department of Dermatology, University of California, San Francisco, California, United States of America.

Atypical fibroxanthoma (AFX), is a rare type of skin cancer affecting older individuals with sun damaged skin. Since there is limited genomic information about AFX, our study seeks to improve the understanding of AFX through whole-exome and RNA sequencing of 8 matched tumor-normal samples. AFX is a highly mutated malignancy with recurrent mutations in a number of genes, including COL11A1, ERBB4, CSMD3, and FAT1. Read More

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December 2017
5 Reads

Atypical fibroxanthoma arising within erosive pustular dermatosis of the scalp.

Cutis 2017 Sep;100(3):E14-E16

Department of Dermatology, Upstate Medical University, Syracuse, New York, USA.

We describe a painful atypical fibroxanthoma (AFX) arising in a setting of erosive pustular dermatosis of the scalp. Complete excision was curative and also was associated with resolution of pain and clearance of the erosive pustular dermatosis of the scalp. We review the diagnosis and management of AFX and discuss the role of actinic damage in this process. Read More

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September 2017
3 Reads

Atypical fibroxanthoma and pleomorphic dermal sarcoma harbor frequent NOTCH1/2 and FAT1 mutations and similar DNA copy number alteration profiles.

Mod Pathol 2018 Mar 3;31(3):418-428. Epub 2017 Nov 3.

Dermatopathology Friedrichshafen, Friedrichshafen, Germany.

Atypical fibroxanthomas and pleomorphic dermal sarcomas are tumors arising in sun-damaged skin of elderly patients. They have differing prognoses and are currently distinguished using histological criteria, such as invasion of deeper tissue structures, necrosis and lymphovascular or perineural invasion. To investigate the as-yet poorly understood genetics of these tumors, 41 atypical fibroxanthomas and 40 pleomorphic dermal sarcomas were subjected to targeted next-generation sequencing approaches as well as DNA copy number analysis by comparative genomic hybridization. Read More

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March 2018
3 Reads

Osseointegrated Prosthetic Ear Reconstruction in Cases of Skin Malignancy: Technique, Outcomes, and Patient Satisfaction.

Ann Plast Surg 2018 Jan;80(1):32-39

Background: Ear reconstruction with osseointegrated prosthetic implants is a well-established method of reconstruction after resection of skin malignancies on the external ear. There is limited literature reporting technique, outcomes, and patient satisfaction.

Methods: We evaluated our outcomes over a 5-year period looking at osseointegrated prosthetic reconstruction after auriculectomy for external ear skin malignancies. Read More

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January 2018
5 Reads

[A pink nodule on the face].

Pan Afr Med J 2017 18;27:205. Epub 2017 Jul 18.

Service de Dermatologie, Centre Hospitalier Universitaire Ibn Sina, Rabat, Maroc.

We report the case of a 32-year old female patient, with no notable medical history, requiring dermatology consultation for evaluation of a nodule on her right cheek which had evolved over the past 10 years. Clinical examination showed a reddish dermal-based nodule with a smooth surface. The lesion measured 1cm in diameter and was located at the level of the right cheek (A). Read More

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October 2017
2 Reads

Recurrent conjunctival atypical fibroxanthoma in Pigmentosum Xeroderma.

Arch Soc Esp Oftalmol 2018 Feb 23;93(2):97-100. Epub 2017 Aug 23.

Departamento de Oftalmología, Hospital Universitario y Politécnico la Fe, Valencia, España.

Case Report: A 7 year-old boy with Xeroderma Pigmentosum (XP) and who presents a recurrent conjunctival atypical fibroxanthoma after two surgeries. This is the third procedure and the patient is treated with a surgical excision of the tumour and cryotherapy at the surgical bed. Due to the risk of recurrence, topical Mitomycin C 0,02% was added at post-operative care achieving a good clinical outcome. Read More

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February 2018
3 Reads

Atypical fibroxanthoma management: Recurrence, metastasis and disease-specific death.

Australas J Dermatol 2018 Feb 17;59(1):10-25. Epub 2017 Aug 17.

Skin and Cancer Foundation, Sydney, New South Wales, Australia.

Atypical fibroxanthoma (AFX) is a rare spindle cell neoplasm predominantly found on the head and neck of elderly individuals with sun-damaged skin, with no evidence-based guidelines for their management. A systematic retrospective review of the literature focusing on treatment modality found a recurrence and metastasis rate of 8.0% (5. Read More

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February 2018
3 Reads

Fibrohistiocytic Tumors.

Clin Lab Med 2017 09 15;37(3):603-631. Epub 2017 Jun 15.

Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Mayo Clinic, Hilton 11, 200 First Street Southwest, Rochester, MN 55905, USA. Electronic address:

Fibrohistiocytic tumors are a diverse group of reactive and neoplastic lesions including xanthoma, fibrous histiocytoma and its variants, solitary xanthogranuloma, dermatofibrosarcoma protuberans, and atypical fibroxanthoma. This article reviews some of the more commonly encountered fibrohistiocytic tumors with an emphasis on clinical presentation, macroscopic and histologic characteristics, molecular/cytogenetic findings where applicable, and differential diagnoses. Read More

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September 2017
5 Reads

Conception and Management of a Poorly Understood Spectrum of Dermatologic Neoplasms: Atypical Fibroxanthoma, Pleomorphic Dermal Sarcoma, and Undifferentiated Pleomorphic Sarcoma.

Curr Treat Options Oncol 2017 08;18(8):50

Department of Dermatology, Stanford University School of Medicine, 450 Broadway Street Pavilion C, 2nd Floor, Redwood City, CA, 94063, USA.

Opinion Statement: Atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS) tumors share many clinical, etiologic, and histologic features and likely represent components of a tumor spectrum. In dermatologic oncology, differentiating between AFX and PDS is pivotal as tumors with histological features consistent with PDS are more likely to behave in a clinically aggressive manner. Importantly, the term "pleomorphic dermal sarcoma" (PDS) is a more appropriate designation than "undifferentiated pleomorphic sarcoma" (UPS) for describing deeper, more aggressive, histologically high-grade cutaneous tumors that otherwise resemble AFX. Read More

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August 2017
4 Reads

Clear-cell atypical fibroxanthoma: An unusual case in an unusual place.

J Cutan Pathol 2017 Nov 22;44(11):951-953. Epub 2017 Aug 22.

Ronald Reagan UCLA Medical Center, University of California, Los Angeles, California.

Atypical fibroxanthoma represents a low-grade sarcoma that usually presents in the elderly population on sun-damaged areas of the head and neck regions. This neoplasm is characterized on histology by atypical pleomorphic, epithelioid to spindled cells, arranged in a haphazard pattern, set within a background of solar elastosis. In this case report, we present a unique case of the rare variant of clear-cell atypical fibroxanthoma arising in an unusual place, specifically the lower extremities. Read More

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November 2017
4 Reads

Phosphohistone-H3 and Ki67: Useful Markers in Differentiating Dermatofibroma From Dermatofibrosarcoma Protuberans and Atypical Fibrohistiocytic Lesions.

Am J Dermatopathol 2017 Jul;39(7):504-507

*Department of Pathology, Baylor University Medical Center, Dallas, TX; †Department of Pathology, Pathologist Biomedical Laboratories, Dallas, TX; ‡Department of Pathology, UF Health, Jacksonville, Jacksonville, FL; §Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX; and ¶Department of Pathology, MD Anderson Cancer Center, Houston, TX.

Dermatofibromas (DF) are common, benign, skin tumors, usually easily differentiated from dermatofibrosarcoma protuberans (DFSP) by the presence of a relative low cellularity, lesser degree of infiltration of subcutaneous tissue, and immunohistochemical pattern (eg, FXIIIa in DF and CD34 in DFSP). Atypical fibrohistiocytic lesions (AFL) have features intermediate to DF and DFSP (trunk location, storiform pattern, infiltration of the subcutaneous tissue, and focal expression of both CD34 and Factor XIIIa). It is unclear if mitotic counts/degree of proliferation is helpful to distinguish DF from DFSP. Read More

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July 2017
3 Reads

Cutaneous sarcomas.

J Dtsch Dermatol Ges 2017 Jun;15(6):630-648

Department of Dermatology and Allergology, Munich Technical University, Munich, Germany.

Cutaneous sarcomas comprise a heterogeneous group of mesenchymal spindle cell tumors of the dermis and subcutis, one of the best-known entities being dermatofibrosarcoma protuberans. Other sarcomas addressed in this review include atypical fibroxanthoma, cutaneous undifferentiated pleomorphic sarcoma, leiomyosarcoma, liposarcoma, and angiosarcoma. With the exception of dermatofibrosarcoma protuberans, which has its peak incidence in middle-aged adults, cutaneous sarcomas usually occur in elderly individuals starting in the sixth or seventh decade of life. Read More

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June 2017
4 Reads

Electronic brachytherapy management of atypical fibroxanthoma: report of 8 lesions.

J Contemp Brachytherapy 2017 Apr 25;9(2):158-160. Epub 2017 Jan 25.

DermaHealth Dermatology & Dermasurgery, Richland, WA, USA.

Purpose: To evaluate the suitability of treating atypical fibroxanthoma (AFX), an uncommon skin malignancy, with electronic brachytherapy.

Material And Methods: From Feb 2013 to Sep 2014, we were referred a total of 8 cases of AFX in 7 patients, all involving the scalp. All of them were treated with electronic brachytherapy 50 Kev radiations (Xoft Axxent, Fremont, California). Read More

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April 2017
5 Reads

Atypical Fibroxanthoma Revisited.

Surg Pathol Clin 2017 Jun 14;10(2):319-335. Epub 2017 Mar 14.

Department of Pathology, University of Edinburgh, United Kingdom.

Atypical fibroxanthoma (AFX) represents a rare mesenchymal neoplasm arising predominantly in the head and neck area of elderly patients. Clinically, the neoplasm is characterized by a rapid and exophytic growth with frequent ulceration of the epidermis. Histopathologically, AFX represents a well-circumscribed, dermal-based neoplasm composed of a variable admixture of large histiocytoid cells, enlarged spindled and epithelioid tumor cells, and multinucleated tumor giant cells with bizarre and pleomorphic nuclei. Read More

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June 2017
2 Reads

Brain and lung metastasis secondary to metastatic atypical fibroxanthoma: A rare Australian case.

Australas J Dermatol 2017 May;58(2):150-151

Princess Alexandra Hospital, Brisbane, Queensland,, Australia.

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May 2017
1 Read

Trichoscopic Patterns in Squamous Cell Carcinoma: : A Case Report.

Int J Trichology 2016 Oct-Dec;8(4):191-194

Department of Pathology, S Nijalingappa Medical College, Bagalkot, Karnataka, India.

Squamous cell carcinoma (SCC) is the second most cutaneous malignancy after basal cell carcinoma (BCC) with increasing incidence. In the view its nodular manifestation; it can appear similar to nodular BCC, atypical fibroxanthoma, sclerosing liposarcoma and desmoplastic melanoma. Prognostic and therapeutic implications are different in all these conditions and thus their distinction becomes important. Read More

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April 2017
5 Reads

Dermatomyofibromas Arising in Children: Report of Two New Cases and Review of the Literature.

Pediatr Dermatol 2017 May 20;34(3):347-351. Epub 2017 Mar 20.

Department of Dermatology, Mayo Clinic, Rochester, Minnesota.

Dermatomyofibroma is a rare, benign mesenchymal proliferation not commonly reported in children. Two patients with biopsy-proven dermatomyofibroma were identified (one female, one male) at our institution, both with rather atypical clinical presentations. The clinical and histopathologic findings and a review of the literature are presented here. Read More

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Granular cell differentiation: A review of the published work.

J Dermatol 2017 Mar;44(3):251-258

Boston University School of Medicine, Boston, Massachusetts, USA.

Since the initial description of the granular cell tumor in 1926, numerous other neoplasms, both benign and malignant, have been described to exhibit granular cell change. In most cases, diagnosis remains straightforward via recognition of retained histopathological morphology of the archetypal tumor, despite the presence of focal granular appearance. However, tumors with granular cell differentiation can present a diagnostic challenge either by mimicking alternative diagnoses, or by failing to exhibit architectural clues of the primary entity, thus requiring an immunohistochemical work-up. Read More

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March 2017
1 Read

Commentary to the Article "A Rare Collision in Dermatopathology: Basal Cell Carcinoma and Atypical Fibroxanthoma".

Am J Dermatopathol 2018 Jan;40(1):75-76

Service of Dermatology, Centro Médico-Cirúrgico Lisboa, Lisboa, Portugal.

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January 2018
3 Reads

Dermatofibroma-like granular cell tumour: a potential diagnostic pitfall.

Pol J Pathol 2016;67(3):291-294

The Fingerland Department of Pathology, Charles University in Prague, Faculty of Medicine and University Hospital in Hradec Králové, Czech Republic.

Dermatofibroma-like granular cell tumour (GCT) is a rare entity, with only two cases having been described so far. We report another case in a 62-year-old woman, discuss histopathological features, and review other tumours in which granular changes have been observed. Our tumour was composed predominantly of oval-to-spindle granular cells with prominent nucleoli, arranged in short fascicles and storiform pattern, infiltrating around collagen bundles. Read More

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June 2017
2 Reads

Aberrant tyrosinase expression in an atypical fibroxanthoma: A case report.

J Cutan Pathol 2017 May 16;44(5):467-469. Epub 2017 Feb 16.

Division of Dermatology, Rutgers University - New Jersey Medical School, Newark, New Jersey.

Atypical fibroxanthoma (AFX) is a histologic mimicker of a variety of spindle cell neoplasms, and careful microscopic and immunohistochemical evaluation is critical in establishing the correct diagnosis. Here we report the histologic and immunohistochemical work up of a 1 cm nodule involving the left dorsal hand of a 66-year-old patient. Light microscopy revealed fascicles of spindled and pleomorphic cells within the dermis showing increased mitotic activity occurring in the background of sun-damaged skin. Read More

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May 2017
1 Read

LN2, CD10, and Ezrin Do Not Distinguish Between Atypical Fibroxanthoma and Undifferentiated Pleomorphic Sarcoma or Predict Clinical Outcome.

Dermatol Surg 2017 Mar;43(3):431-436

*Division of Dermatology, Department of Medicine, Vanderbilt University, Nashville, Tennessee; †Department of Dermatology, University of Oklahoma, Oklahoma City, Oklahoma; ‡Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut.

Background: Atypical fibroxanthoma (AFX) is a rare cutaneous spindled cell neoplasm. For both diagnostic and therapeutic purposes, it is important to distinguish AFX from other poorly differentiated tumors, including undifferentiated pleomorphic sarcoma (UPS).

Objective: The authors aimed to identify the clinical, histologic, and immunohistochemical expression of LN2, ezrin, and CD10 in AFX and UPS tumors. Read More

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March 2017
8 Reads

Evidence-Based Medicine: Cutaneous Facial Malignancies: Nonmelanoma Skin Cancer.

Plast Reconstr Surg 2017 Jan;139(1):181e-190e

New York, N.Y. From the Dermatology Service and the Plastic Surgery Service, Memorial Sloan Kettering Cancer Center.

Learning Objectives: After studying this article, the participant should be able to: 1. Identify clinical features of nonmelanoma skin cancer; 2. Distinguish low-risk versus high-risk basal cell carcinoma and squamous cell carcinoma; 3. Read More

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January 2017
2 Reads

Incidence and Clinical Features of Rare Cutaneous Malignancies in Olmsted County, Minnesota, 2000 to 2010.

Dermatol Surg 2017 Jan;43(1):116-124

*Department of Dermatology, Mayo Clinic, Rochester, Minnesota;†Division of Biomedical Statistics and Informatics, Mayo Clinic Rochester, Minnesota;‡Division of Dermatologic Surgery, Mayo Clinic, Rochester, Minnesota.

Background: The incidence of rare cutaneous malignancies is unknown. Current estimates of rare cutaneous malignancy incidences are based on broad epidemiologic data or single institution experiences, not population-based data.

Objective: To determine the incidence of several rare nonmelanoma skin cancers. Read More

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January 2017
5 Reads

Dermatofibroma of the eyelid with monster cells.

Surv Ophthalmol 2017 Jul - Aug;62(4):533-540. Epub 2016 Dec 22.

Department of Dermatology, Massachusetts General Hospital.

Dermatofibromas are most frequently encountered in women on the lower extremities, often after minor trauma. A recurrent lesion of the right lower eyelid developed in a 64-year-old woman. It harbored "monster cells" that were large, with either multiple nuclei or a single, large, convoluted, and hyperchromatic nucleus. Read More

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September 2017
1 Read

Atypical fibroxanthoma of the scalp with recurrent and multiple regional cutaneous metastases.

JAAD Case Rep 2016 Nov 7;2(6):491-493. Epub 2016 Dec 7.

University of Central Florida, College of Medicine, Orlando, Florida.

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November 2016

Recurrent cutaneous angiosarcoma of the ear masquerading as atypical fibroxanthoma.

JAAD Case Rep 2016 Nov 5;2(6):445-447. Epub 2016 Dec 5.

Melanoma and Cutaneous Oncology Program, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah; Intermountain Health Care, Salt Lake City, Utah.

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November 2016
2 Reads

Non-lymphoid lesions that may mimic cutaneous hematopoietic neoplasms histologically.

Semin Diagn Pathol 2017 Jan 29;34(1):99-107. Epub 2016 Nov 29.

From the Section of Dermatopathology, Division of Surgical Pathology & Cytopathology, University of Virginia Health System, Charlottesville, VA, USA.

This review considers neoplastic lesions that originate in the skin, and which have the potential to imitate hematopoietic proliferations at a histological level. They include lymphoepithelioma-like carcinoma, Merkel cell carcinoma, benign lymphadenoma, pseudolymphomatous angiosarcoma, lymphadenoid dermatofibroma, lymphomatoid atypical fibroxanthoma, histiocytoid (epithelioid) hemangioma, and inflamed melanocytic lesions. The clinical and pathological features of those tumors are considered. Read More

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January 2017
2 Reads

Mohs micrographic surgery of rare cutaneous tumours.

J Eur Acad Dermatol Venereol 2017 Aug 24;31(8):1285-1288. Epub 2017 Jan 24.

Department of Dermatology, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, The Netherlands.

Background: Recurrence rates after Mohs micrographic surgery (MMS) for rare cutaneous tumours are poorly defined.

Objective: To investigate the recurrence rate after MMS for rare cutaneous tumours at a university centre.

Methods & Materials: Retrospective review of all rare cutaneous tumours treated with MMS at a large university centre between January 2008 and December 2012. Read More

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August 2017
3 Reads

High prevalence of MiTF staining in undifferentiated pleomorphic sarcoma: caution in the use of melanocytic markers in sarcoma.

Histopathology 2017 Apr 1;70(5):734-745. Epub 2017 Feb 1.

Department of Pathology, The University of Chicago Medicine, Chicago, IL, USA.

Aims: The diagnosis of undifferentiated pleomorphic sarcoma (UPS) may be challenging, as other lesions with undifferentiated spindle cell morphology must be excluded, including melanoma. Microphthalmia-associated transcription factor (MiTF) stains naevi and epithelioid melanomas, as well as some mesenchymal neoplasms. The aim of this study was to evaluate the prevalence of MiTF and melanocytic markers in UPS and a subset of atypical fibroxanthoma (AFX). Read More

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April 2017
3 Reads

Lesion presenting with a "blue amber" pattern.

World J Clin Cases 2016 Oct;4(10):333-335

Calogero Pagliarello, Francesca Peccerillo, Alfredo Zucchi, Rocco Giuseppe Tortorella, Roberto Ricci, Ignazio Stanganelli, Claudio Feliciani, Sergio Di Nuzzo, Section of Dermatology, Department of Clinical and Experimental Medicine, University of Parma, 43100 Parma, Italy.

Atypical fibroxanthoma (AFX) is a spindle cell neoplasm with low metastatic potential but high tendency to recur after surgery. Because of the rarity of this lesion and its aspecific clinical features, AFX could be easily misdiagnosed and undertreated by many clinicians who encounter them. Dermoscopy represents a valuable tool for easily assessing skin lesions, even though histological examination is required for final diagnosis. Read More

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October 2016
1 Read

Case of Pleomorphic Dermal Sarcoma of the Eyelid Treated with Micrographic Surgery and Secondary Intention Healing.

Ann Dermatol 2016 Oct 30;28(5):632-636. Epub 2016 Sep 30.

Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

Pleomorphic dermal sarcoma (PDS) is a rare mesenchymal neoplasm sharing histopathological features with atypical fibroxanthoma (AFX), but has additional features of deep invasion of the superficial subcutis, tumor necrosis and vascular/perineural invasion. It is not well documented in the literature because of its rarity, and its clinical course has been debated due to the lack of homogenous criteria. We describe here the case of a 91-year-old female with a 6-month history of a solitary, asymptomatic, well-defined, 3. Read More

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October 2016
28 Reads

Ulcerated Giant Dermatofibroma following Routine Childhood Vaccination in a Young Boy.

Case Rep Dermatol 2016 May-Aug;8(2):210-217. Epub 2016 Aug 9.

Dermatology Service, KK Women's and Children's Hospital, Singapore, Singapore.

Introduction: The development of cutaneous neoplasms at immunization sites following vaccination is uncommon, and only few have been reported in the literature worldwide. We report an unusual case of an ulcerated giant dermatofibroma that developed as a chronic nonhealing plaque in the immunization scar of a young boy after vaccination.

Case Report: A 13-month-old Chinese boy presented with an unusual skin reaction on the vaccination site at the right anterolateral thigh following a routine intramuscular injection of '5-in-1' (diphtheria, tetanus, pertussis, polio and B) vaccine at 4 months of age. Read More

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August 2016
1 Read

CELLULAR FIBROUS DERMATOFIBROMA OF THE SOLE.

Georgian Med News 2016 Jul(256-257):11-3

Academic Teaching Hospital Dresden-Friedrichstadt, Department of Dermatology and Allergology; Institute of Pathology "Georg Schmorl"; Department of Anesthesiology and Intensive Care Medicine, Emergency Medicine and Pain Management, Dresden, Germany.

Cellular fibrous dermatofibroma is a rare variant of dermatofibroma/histiocytoma. We present a 61 years old female with a slow-growing, firm tumor on the sole of her right foot. The tumor was removed by slow Mohs surgery within 2 cm negative margin. Read More

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July 2016
1 Read

[Clinicopathologic analysis of extranodal Rosai-Dorfman disease of breast: a report of 12 cases].

Zhonghua Bing Li Xue Za Zhi 2016 Aug;45(8):556-60

Department of Pathology, Fujian Provincial Cancer Hospital, Teaching Hospital of Fujian Medical University, Fuzhou 350014, China.

Objective: To investigate the clinicopathologic features, diagnosis and differential diagnosis of extranodal Rosai-Dorfman disease(RDD)of the breast.

Methods: Twelve cases of extranodal RDD of the breast were analyzed using hematoxylin-eosin stain and immunohistochemical staining.The morphological features and immunophenotype were observed by light microscopy, accompanied with a review of the literature. Read More

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August 2016
18 Reads

Keloidal Atypical Fibroxanthoma: Case and Review of the Literature.

Case Rep Dermatol 2016 May-Aug;8(2):156-63. Epub 2016 Jun 6.

University of Miami Miller School of Medicine, Miami, Fla., USA.

Keloidal atypical fibroxanthoma (KAF) has recently been categorized as a variant of atypical fibroxanthoma. This paper will emphasize the importance of including KAF in both clinical and histological differential diagnosis of benign and malignant lesions which exhibit keloidal collagen and will also review the current literature on epidemiology, pathogenesis, histology, immunochemistry and treatments. Read More

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July 2016
1 Read

Plaque-Like Atypical Fibroxanthoma, A Rare Invasive Variant.

Dermatol Surg 2017 Jan;43(1):138-139

Department of Dermatology, University of Colorado School of Medicine, Aurora, Colorado.

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January 2017