117,218 results match your criteria Atypical Antipsychotics : Milestones in Drug Therapy[Journal]


Sultans of Swing: A Reappraisal of the Intertwined Association Between Affective Lability and Mood Reactivity in a Post Hoc Analysis of the BRIDGE-II-MIX Study.

J Clin Psychiatry 2019 Feb 19;80(2). Epub 2019 Feb 19.

Bipolar Disorder Unit, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.

Objective: This post hoc analysis of the BRIDGE-II-MIX study is aimed at evaluating affective lability (AL) as a possible clinical feature of mixed depression and assessing the relationship with atypical depressive features, particularly mood reactivity (MR).

Methods: In the BRIDGE-II-MIX multicenter, cross-sectional study, 2,811 individuals suffering from a major depressive episode (MDE; DSM-IV-TR criteria), in the context of bipolar I or II disorder (BD-I, BD-II, respectively) or major depressive disorder, were enrolled between June 2009 and July 2010. Patients with (MDE-AL, n = 694) and without (MDE-noAL, n = 1,883) AL and with (MDE-MR, n = 1,035) or without (MDE-noMR, n = 1,542) MR were compared through χ² test or Student t test. Read More

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http://dx.doi.org/10.4088/JCP.17m12082DOI Listing
February 2019

Significance of subepithelial deposits in patients diagnosed with IgA nephropathy.

PLoS One 2019 20;14(2):e0211812. Epub 2019 Feb 20.

Department of Nephrology, Nagasaki University Hospital, Nagasaki, Japan.

Subepithelial deposits are observed in rare adult IgA nephropathy (IgAN) cases and are a key diagnostic finding in IgA-dominant infection-related glomerulonephritis (IgA-IRGN). Sometimes, it is difficult to distinguish IgA-IRGN from IgAN without a precise clinical history. We hypothesized that some IgA-IRGN cases might be diagnosed as IgAN with subepithelial deposits (IgAN-SD) and aimed to clarify the significance of subepithelial deposits in patients diagnosed with IgAN. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211812PLOS
February 2019

Matrical Carcinoma with Melanocytic Hyperplasia Mimicking Nodular Melanoma in an Elderly Mexican Male.

J Cutan Pathol 2019 Feb 20. Epub 2019 Feb 20.

Department of Dermatology, University of California, Irvine.

Matrical carcinoma with melanocytic hyperplasia (MCMH), previously referred to as malignant melanocytic matricoma, is a rare variant of the uncommon pilomatrical carcinoma, which occurs most often on the head/neck and upper backs of middle-aged men. Nodular lesions may resemble pigmented basal cell carcinoma or melanoma clinically. We present a case of MCMH in a Hispanic patient with history of melanoma. Read More

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http://dx.doi.org/10.1111/cup.13445DOI Listing
February 2019

DIGESTIVE DISEASES IN ELDERLY AND FACTORS ASSOCIATED WITH LENGTH OF STAY IN THE HEPATOLOGY AND GASTROENTEROLOGY UNIT OF THE CAMPUS TEACHING HOSPITAL OF LOME (TOGO).

Arq Gastroenterol 2018 Oct-Dec;55(4):369-374

Hepatology and Gastroenterology Unit of the Campus Teaching Hospital of Lome, Togo.

Background: The digestive pathologies are frequent in the elderly and often have a latent and atypical symptomatology.

Objective: To assess the epidemiological and evolutionary current data on digestive diseases in the elderly, and look for factors associated with length of hospital stay.

Methods: Retrospective study of 10 years, including patients aged 60 and over hospitalized for digestive diseases in the Gastroenterology Department of the Campus Teaching Hospital of Lome, Togo. Read More

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http://dx.doi.org/10.1590/S0004-2803.201800000-80DOI Listing

Clinicopathological and immunohistochemical analysis of spindle cell squamous cell carcinoma of the tongue: a rare case.

Einstein (Sao Paulo) 2019 Feb 18;17(1):eRC4610. Epub 2019 Feb 18.

Universidade Estadual da Paraíba, Campina Grande, PB, Brazil.

Spindle cell squamous cell carcinoma of the tongue is a rare variant of squamous cell carcinoma. This paper reports the case of a spindle cell squamous cell carcinoma of the tongue, in a 64-year-old male patient, and presents a review of the etiopathogenesis, clinicopathological and immunohistochemical features and treatment of the malignancy. The patient presented for evaluation of a painful swelling on his tongue. Read More

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http://dx.doi.org/10.31744/einstein_journal/2019RC4610DOI Listing
February 2019

Developments in depression in epilepsy: screening, diagnosis and treatment.

Authors:
Marco Mula

Expert Rev Neurother 2019 Feb 20. Epub 2019 Feb 20.

a Institute of Medical and Biomedical Education, St George's University of London and The Atkinson Morley Regional Neuroscience Centre, St George's University Hospitals NHS Foundation Trust , London , United Kingdom.

Introduction: Depression is one of the most frequent comorbidities in epilepsy affecting between 17% and 22% of patients but it is still underdiagnosed and undertreated. Areas covered: This paper discusses recent advances about screening, diagnosis and treatment of depression in epilepsy taking into account the heterogeneity of clinical scenarios where depression can occur. Expert opinion: A number of screening instruments are now validated for adults with epilepsy and their psychometric properties are discussed but the NDDIE is the most practical and cost-effective. Read More

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http://dx.doi.org/10.1080/14737175.2019.1585244DOI Listing
February 2019

Effects of ethyl ester supplementation to forage on short-term dry matter intake and preference by goats.

Arch Anim Nutr 2019 Feb 20:1-13. Epub 2019 Feb 20.

a Institute of Animal Science , University of Bonn , Bonn , Germany.

In whole-crop maize silages with atypical smell and decreased acceptance by ruminants, high concentrations of the volatile organic compounds ethyl acetate (EA) and ethyl lactate (EL) were detected. The aim of this study was to evaluate the impact of different concentrations of ethyl esters added to forage on preference and short-term feed intake of goats. In the first of three trials, whole-crop maize silage was supplemented with different concentrations of EA and EL and then vacuum-stored before use. Read More

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http://dx.doi.org/10.1080/1745039X.2019.1575656DOI Listing
February 2019

Management of choroid plexus tumors-an institutional experience.

Acta Neurochir (Wien) 2019 Feb 19. Epub 2019 Feb 19.

Department of Neurosurgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Background: Choroid plexus tumors are rare entities. Resection is the mainstay of treatment in grade I and grade II tumors and adjuvant treatment is usually reserved for the less frequent choroid plexus carcinoma (CPC). Outcome is not only related to their histological grade but also dependent on their size, location, and presence of often multifactorial disturbances of cerebrospinal fluid (CSF) circulation. Read More

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http://dx.doi.org/10.1007/s00701-019-03832-5DOI Listing
February 2019

The VWFA Is the Home of Orthographic Learning When Houses Are Used as Letters.

eNeuro 2019 Jan-Feb;6(1). Epub 2019 Feb 15.

Department of Psychology.

Learning to read specializes a portion of the left mid-fusiform cortex for printed word recognition, the putative visual word form area (VWFA). This study examined whether a VWFA specialized for English is sufficiently malleable to support learning a perceptually atypical second writing system. The study utilized an artificial orthography, HouseFont, in which house images represent English phonemes. Read More

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http://dx.doi.org/10.1523/ENEURO.0425-17.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378324PMC
February 2019

Kimura's disease associated with IgA nephropathy: A case report.

Exp Ther Med 2019 Mar 17;17(3):1837-1840. Epub 2018 Dec 17.

Department of Nephrology, Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116000, P.R. China.

Kimura's disease (KD) is a rare chronic inflammatory disorder of unknown etiology that manifests as painless subcutaneous lesions in the head and neck. It primarily affects young Asian males and is characterized by peripheral eosinophilia and elevated levels of serum Immunoglobulin (Ig)E. Histologically, a variety of renal lesions have been observed in patients with KD, although IgA nephropathy is rarely reported. Read More

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http://dx.doi.org/10.3892/etm.2018.7103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364220PMC

Breast Fine Needle Aspiration Biopsy Cytology Using the Newly Proposed IAC Yokohama System for Reporting Breast Cytopathology: The Experience of a Single Institution.

Acta Cytol 2019 Feb 15:1-6. Epub 2019 Feb 15.

Institute of Molecular Pathology and Immunology, University of Porto, Porto,

Objective: Recently the International Academy of Cytology (IAC) proposed a new reporting system for breast fine needle aspiration biopsy (FNAB) cytology. We aimed to categorize our samples according to this classification and to assess the risk of malignancy (ROM) for each category as well as the diagnostic yield of breast FNAB.

Study Design: Breast FNAB specimens obtained between January 2007 and December 2017 were reclassified according to the newly proposed IAC Yokohama reporting system. Read More

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http://dx.doi.org/10.1159/000492638DOI Listing
February 2019

Differential cortical microstructural maturation in the preterm human brain with diffusion kurtosis and tensor imaging.

Proc Natl Acad Sci U S A 2019 Feb 19. Epub 2019 Feb 19.

Radiology Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104;

During the third trimester, the human brain undergoes rapid cellular and molecular processes that reshape the structural architecture of the cerebral cortex. Knowledge of cortical differentiation obtained predominantly from histological studies is limited in localized and small cortical regions. How cortical microstructure is differentiated across cortical regions in this critical period is unknown. Read More

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http://dx.doi.org/10.1073/pnas.1812156116DOI Listing
February 2019

Legionnaire's-disease-associated meningoencephalitis: A case report.

Pulmonology 2019 Feb 16. Epub 2019 Feb 16.

Department of Neurology, Saarland University Medical Center, Kirrberger Str., 66421 Homburg, Germany.

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http://dx.doi.org/10.1016/j.pulmoe.2018.12.006DOI Listing
February 2019

Atypical diaphyseal femoral fractures: Considerations on surgical technique.

Injury 2019 Feb 2. Epub 2019 Feb 2.

Department of Musculoskeletal Oncology, "Palazzo Baleani" Umberto I University Hospital, Rome, Italy.

In the last two decades bisphosphonates (BP) has become the mainstream therapy for osteoporosis and the benefit in reducing the incidence of fractures has been well demonstrated in several studies, together with the drug long term (5-10 years) efficacy and safety. A complication of the long-term use of bisphosphonates is a low-energy stress fractures located in the sub-trochanteric region and the femoral shaft called atypical femur fracture (AFF). These stress fractures can be seen on plain radiographs as simple transverse patterns, with unicortical beaking and hypertrophy of the diaphyseal lateral cortex. Read More

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http://dx.doi.org/10.1016/j.injury.2019.01.048DOI Listing
February 2019

Outcomes of endometrial assessment in women with unscheduled bleeding on hormone replacement therapy.

Post Reprod Health 2019 Feb 19:2053369119830822. Epub 2019 Feb 19.

King's College Hospital NHS Foundation Trust Ringgold standard institution - Gynaecology, London, UK.

Objective: This study correlates the transvaginal ultrasound findings with histopathology results in women who present with unscheduled bleeding on hormone replacement therapy.

Study Design: Retrospective analysis of 469 consecutive cases with unscheduled bleeding on hormone replacement therapy (203 patients on sequential hormone replacement therapy (seq-HRT) and 266 patients on continuous combined hormone replacement therapy (con-HRT)).

Main Outcome Measures: Outcomes of endometrial assessment in women with unscheduled bleeding on hormone replacement therapy. Read More

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http://dx.doi.org/10.1177/2053369119830822DOI Listing
February 2019

Distribution of Papaya ringspot virus and Papaya mosaic virus in Papaya Plants (Carica papaya) in Mexico.

Plant Dis 2006 Aug;90(8):1004-1011

Departamento de Ing. Genética, Cinvestav, Km. 9.6 Lib. Nte. Carr. Irapuato-León, 36500, A. P. 629, Irapuato, Gto. Mexico.

We report the results of a survey for the presence of Papaya ringspot virus (PRSV) along the coasts of the Gulf of Mexico and the Pacific Ocean, in 15 federal states of Mexico that account for over 98% of the national papaya production. More than 80 locations were visited in 58 counties. Out of a total of 267 papaya leaf samples, 157 tested positive for PRSV. Read More

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http://dx.doi.org/10.1094/PD-90-1004DOI Listing

Pseudomonas viridiflava Causing Necrotic Leaf Spots and Defoliation on Hebe spp. in Northern Spain.

Plant Dis 2006 Jun;90(6):830

Departamento de Biología Funcional (Área de Microbiología), Universidad de Oviedo and Instituto Universitario de Biotecnología de Asturias (IUBA), Julián Clavería 6, 33006 Oviedo, Asturias. Spain.

Hebe spp. is gaining interest as an ornamental crop in Spain. In October of 2003, plants of Hebe spp. Read More

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http://dx.doi.org/10.1094/PD-90-0830ADOI Listing

Position-Selective Synthesis and Biological Evaluation of Four Isomeric A-Ring Amino Derivatives of the Alkaloid Luotonin A.

Molecules 2019 Feb 16;24(4). Epub 2019 Feb 16.

Department of Pharmaceutical Chemistry, University of Vienna, Althanstraße 14, A-1090 Vienna, Austria.

Following two orthogonal synthetic routes, a series of all four possible A-ring amino derivatives of the natural product Luotonin A (a known Topoisomerase I inhibitor) was synthesized. In both strategies, intramolecular cycloaddition reactions are the key step. The target compounds were obtained in good yields by mild catalytic transfer hydrogenation of the corresponding nitro precursors. Read More

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http://dx.doi.org/10.3390/molecules24040716DOI Listing
February 2019

Anomalous one-dimensional fluctuations of a simple two-dimensional random walk in a large-deviation regime.

Phys Rev E 2019 Jan;99(1-1):012110

Institute of Information Transmission Problems RAS, 127051 Moscow, Russia.

The following question is the subject of our work: could a two-dimensional (2D) random path pushed by some constraints to an improbable "large-deviation regime" possess extreme statistics with one-dimensional (1D) Kardar-Parisi-Zhang (KPZ) fluctuations? The answer is positive, though nonuniversal, since the fluctuations depend on the underlying geometry. We consider in detail two examples of 2D systems for which imposed external constraints force the underlying stationary stochastic process to stay in an atypical regime with anomalous statistics. The first example deals with the fluctuations of a stretched 2D random walk above a semicircle or a triangle. Read More

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http://dx.doi.org/10.1103/PhysRevE.99.012110DOI Listing
January 2019

Metastatic Subdural Hematoma with Dural Metastasis Secondary to Poorly Differentiated Adenocarcinoma of Unknown Origin.

World Neurosurg 2019 Feb 16. Epub 2019 Feb 16.

Department of Neurosurgery, Hofstra Northwell School of Medicine, Manhasset, NY. Electronic address:

Background: Metastatic subdural hematoma with dural metastasis in the setting of an underlying malignancy is a rare condition that is difficult to diagnose and associated with a poor prognosis. Knowledge of this rare entity is of a paramount importance to neurosurgeons as its diagnosis may affect the management plan and overall survival. Here, we report a rare case of atraumatic subdural hematoma with dural metastasis in a patient with poorly differentiated adenocarcinoma of unknown origin. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.271DOI Listing
February 2019

Network analysis of DUSP12 partners in the nucleus under genotoxic stress.

J Proteomics 2019 Feb 16. Epub 2019 Feb 16.

Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil. Electronic address:

Dual Specificity Phosphatase 12 is a member of the Atypical DUSP Protein Tyrosine Phosphatase family, meaning that it does not contain typical MAP kinase targeting motifs, while being able to dephosphorylate tyrosine and serine/threonine residues. DUSP12 contains, apart from its catalytic domain, a zinc finger domain, making it one of the largest DUSPs, which displays strong nuclear expression in several tissues. In this work we identified nuclear targets of DUSP12 in two different cancer cell lines (A549 and MCF-7), challenging them with genotoxic stimuli to observe the effect on the networks and to link existing information about DUSP12 functions to the data obtained though mass spectrometry. Read More

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http://dx.doi.org/10.1016/j.jprot.2019.02.008DOI Listing
February 2019

Does outpatient palliative care improve patient-centered outcomes in Parkinson's disease: Rationale, design, and implementation of a pragmatic comparative effectiveness trial.

Contemp Clin Trials 2019 Feb 16. Epub 2019 Feb 16.

Division of Neurology, University of Alberta, 11350-83 Avenue, 7-112 Clinical Sciences Building, Edmonton, AB T6G 2G3, Canada. Electronic address:

Patients with Parkinson's disease and related disorders (PDRD) and their families have considerable unmet needs including non-motor symptom management, caregiver support, spiritual wellbeing, advance care planning, and end-of-life care. There is increasing interest in applying palliative care (PC) models to better meet these needs. While PC has been shown to improve care and quality of life (QOL) for people with cancer and heart failure, few studies have evaluated the role of PC for people with PDRD. Read More

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http://dx.doi.org/10.1016/j.cct.2019.02.005DOI Listing
February 2019

Should progesterone and estrogens receptors be assessed for predicting the response to conservative treatment of endometrial hyperplasia and cancer? A systematic review and meta-analysis.

Acta Obstet Gynecol Scand 2019 Feb 19. Epub 2019 Feb 19.

Obstetrics and Gynecology Unit, Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, Italy.

Introduction: Progestins are used as conservative treatment of endometrial hyperplasia (EH) and early endometrial cancer (EEC). We aimed to assess if immunohistochemical expression of estrogens and progesterone receptors (ER and PR) predicts the treatment response.

Material And Methods: Electronic databases were searched for studies assessing ER and PR expression in EH and EEC treated with progestins. Read More

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http://dx.doi.org/10.1111/aogs.13586DOI Listing
February 2019
1 Read

Network Analysis of Behaviors in the Depression and Autism Realms: Inter-Relationships and Clinical Implications.

J Autism Dev Disord 2019 Feb 18. Epub 2019 Feb 18.

Child Study Center, Yale University School of Medicine, 230 S. Frontage Rd, New Haven, CT, 06519, USA.

Depression-, anxiety-, OCD- and autism-related behaviors were assessed in 118 high-functioning individuals with autism spectrum disorders (ASD) and in 2016 controls. The ASD group had a higher rate of clinical depression and markedly higher "insomnia" and "restlessness" scores. Network analysis and hierarchical cluster analysis in the ASD group revealed that depression and anxiety items clustered together, but separately from autism-related items. Read More

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http://dx.doi.org/10.1007/s10803-019-03914-4DOI Listing
February 2019

An atypical aspartic protease modulates lateral root development in Arabidopsis thaliana.

J Exp Bot 2019 Feb 19. Epub 2019 Feb 19.

Institute for Interdisciplinary Research, University of Coimbra, Portugal.

Few atypical aspartic proteases (APs) present in plants have been functionally studied to date despite having been implicated in developmental processes and stress responses, and diverse biochemical properties were reported for these enzymes. Here we characterize a novel atypical AP that we name ATYPICAL ASPARTIC PROTEASE IN ROOTS 1 (ASPR1), denoting its expression in Arabidopsis roots. Recombinant ASPR1 produced by transient expression in N. Read More

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http://dx.doi.org/10.1093/jxb/erz059DOI Listing
February 2019

Sex Differences in Body Ownership in Adults With Autism Spectrum Disorder.

Front Psychol 2019 4;10:168. Epub 2019 Feb 4.

Neuroscience Area, International School for Advanced Studies, Trieste, Italy.

A strong male prevalence has been observed in autism spectrum disorder (ASD) since its definition, but the behavioral manifestations of sex disparity have yet to be clarified. Here, we investigate sex differences in the perception of the Numbness Illusion (NI), a procedure based on a tactile conflict, in adults with ASD and with typical development. We aim to assess if women and men with ASD perceive NI-dependent body ownership differently and whether sex differences emerge in individuals with typical development. Read More

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http://dx.doi.org/10.3389/fpsyg.2019.00168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369199PMC
February 2019

[Burning mouth syndrome].

Zh Nevrol Psikhiatr Im S S Korsakova 2019 ;119(1):76-79

Sechenov First Moscow State Medical University, Moscow, Russia.

A case-report of burning mouth syndrome is presented. A 27-year-old man complained of burning pain in the tongue and oral mucosa, taste disorder, and sensory impairment. All symptoms appeared after suffering a cold and had a wave-like course during self-medication with antibiotics. Read More

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http://dx.doi.org/10.17116/jnevro201911901176DOI Listing
January 2019

[Takayasu arteritis of atypical presentation. Tocilizumab as an alternative therapeutic option].

An Pediatr (Barc) 2019 Feb 15. Epub 2019 Feb 15.

Unidad de Cardiología Pediátrica, Unidad de Gestión Clínica de Pediatría, Hospital Materno Infantil, Hospital Regional Universitario de Málaga, Málaga, España.

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http://dx.doi.org/10.1016/j.anpedi.2019.01.012DOI Listing
February 2019

Population receptive field tuning properties of visual cortex during childhood.

Dev Cogn Neurosci 2019 Jan 8:100614. Epub 2019 Jan 8.

Dept. of Psychology, San Diego State University, USA.

Visuospatial abilities such as contrast sensitivity and Vernier acuity improve until late in childhood, but the neural mechanisms supporting these changes are poorly understood. We tested to which extent this development might reflect improved spatial sensitivity of neuronal populations in visual cortex. To do this, we measured BOLD-responses in areas V1-V4 and V3a, whilst 6- to 12-year-old children and adults watched large-field wedge and ring stimuli in the MRI scanner, and then fitted population receptive field (pRF) tuning functions to these data (Dumoulin and Wandell, 2008). Read More

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http://dx.doi.org/10.1016/j.dcn.2019.01.001DOI Listing
January 2019

Adenoid cystic carcinoma with high-grade transformation forming spindle cell component of the submandibular gland.

Auris Nasus Larynx 2019 Feb 15. Epub 2019 Feb 15.

Department of Pathology, Fukuoka University, School of Medicine, Japan.

Adenoid cystic carcinoma (AdCC) with high-grade transformation (AdCC-HGT) is rare, and AdCC-HGT with spindle cell component is particularly rare. The patient was a 65-year-old man with a 5 cm sized swelling of the right submandibular gland. Submandibular sialoadenectomy was performed. Read More

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http://dx.doi.org/10.1016/j.anl.2019.01.014DOI Listing
February 2019

Clinical, demographic, psychological, and behavioral features of factitious disorder: A retrospective analysis.

Gen Hosp Psychiatry 2019 Jan 31. Epub 2019 Jan 31.

Department of Psychiatry and Psychology, Cleveland Clinic, Cleveland, OH, United States of America.

Background: Consultation psychiatrists are often asked to assess factitious disorder (FD), yet this is challenging as confirmation depends on rarely achieved direct evidence of illness-inducing behaviors. Diagnosis is thus based on other variables, such as atypical features of the medical presentation and certain patient behaviors. This study sought to assess a cohort of patients with FD for demographic and clinical variables, but also psychological and behavioral ones unexamined in previous studies. Read More

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http://dx.doi.org/10.1016/j.genhosppsych.2019.01.009DOI Listing
January 2019

Pathology results of architectural distortion on detected with digital breast tomosynthesis without definite sonographic correlate.

Am J Surg 2019 Jan 31. Epub 2019 Jan 31.

Diagnostic Imaging Northwest PC, Legacy Good Samaritan Hospital, 1015 N.W. 22nd Ave, Portland, OR, 97210, USA.

Background: Digital breast tomosynthesis (DBT) is a mammographic technique which improves the detection of breast cancer. Architectural distortion of malignancy may be occult on 2D mammography and ultrasound but detected by DBT.

Methods: 110 patients who underwent 116 DBT-guided needle biopsies for architectural distortion were identified between June 2014 and August 2017 and underwent review of medical records. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2019.01.029DOI Listing
January 2019

A dedifferentiated solitary fibrous tumor of the parotid gland: a case report with Cytopathologic findings and review of the literature.

Diagn Pathol 2019 Feb 18;14(1):20. Epub 2019 Feb 18.

Department of Otorhinolaryngology, Kung Tien General Hospital, Shalu, Taichung, Taiwan.

Background: Solitary fibrous tumor (SFT) is a ubiquitous mesenchymal neoplasm but it rarely occurs in the parotid gland. The histological features are variable, with the majority having spindle cell morphology and non-specific branching (staghorn) ecstatic vascular pattern. SFT ranges from benign to overtly malignant. Read More

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http://dx.doi.org/10.1186/s13000-019-0792-6DOI Listing
February 2019

Postpneumonectomy-like syndrome due to bronchial carcinoid: a unique case report.

BMC Pulm Med 2019 Feb 18;19(1):44. Epub 2019 Feb 18.

1st Respiratory Medicine Department, University of Athens, "Sotiria" Hospital, 152 Mesogeion Ave, 115 27, Athens, Greece.

Background: Postpneumonectomy-like syndrome is a rare condition resulting from unilateral lung disease with severe lung volume loss leading to excessive mediastinal shift and herniation of the healthy lung into the contralateral hemithorax, mimicking the mediastinal shift observed in postpneumonectomy syndrome after pneumonectomy. We report a unique case of postpneumonectomy-like syndrome caused by an atypical bronchial carcinoid completely occluding the left main bronchus.

Case Presentation: A 25-year-old woman presented with symptoms of chronic exertional dyspnea and productive cough. Read More

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http://dx.doi.org/10.1186/s12890-018-0767-5DOI Listing
February 2019

Limited evidence for diagnosing bacterial skin infections in older adults in primary care: systematic review.

BMC Geriatr 2019 Feb 18;19(1):45. Epub 2019 Feb 18.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Primary Care Building, Radcliffe Observatory Quarter, Woodstock Road, Oxford, OX2 6GG, UK.

Background: Older adults with bacterial skin infections may present with atypical symptoms, making diagnosis difficult. There is limited authoritative guidance on how older adults in the community present with bacterial skin infections. To date there have been no systematic reviews assessing the diagnostic value of symptoms and signs in identifying bacterial skin infections in older adults in the community. Read More

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http://dx.doi.org/10.1186/s12877-019-1061-yDOI Listing
February 2019

A previously unreported type of extra-articular triplane fracture: A revised classification system.

J Orthop Surg (Hong Kong) 2019 Jan-Apr;27(1):2309499019828500

The Department of Orthopaedics and Traumatology, Duchess of Kent Children's Hospital, Hong Kong, China.

Background:: Atypical triplane fractures are defined as triplane fractures that are intra-articular but affect the non-weight-bearing area of the tibia plafond or extra-articular triplane fractures where the epiphyseal fracture line exits outside the articulating cortex of the medial malleolus. These fractures are scarcely reported in the literature. Here, we study the fracture pattern, mechanisms, and recommendations for management. Read More

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http://dx.doi.org/10.1177/2309499019828500DOI Listing
February 2019

Clinical features of atypical femur fracture.

Osteoporos Sarcopenia 2016 Dec 27;2(4):244-249. Epub 2016 Sep 27.

Department of Orthopedic Surgery, College of Medicine, Inha University, Incheon, South Korea.

Objectives: We aim to elucidate the clinical outcomes of bisphosphonate-associated atypical femoral fracture and the clinical results depending on the bisphosphonate therapy period.

Methods: Twenty cases involving 15 patients who had been diagnosed with atypical femoral facture between 2004 and 2014 and who had been followed up for at least 12 months were retrospectively analyzed. The control group was composed of 15 typical femoral facture patients. Read More

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http://dx.doi.org/10.1016/j.afos.2016.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372747PMC
December 2016

Increased proportions of γδ T lymphocytes in atypical SCID associate with disease manifestations.

Clin Immunol 2019 Feb 15. Epub 2019 Feb 15.

Center for Chronic Immunodeficiency, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Center for Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address:

Severe combined immunodeficiencies (SCID) comprise a group of genetic diseases characterized by abrogated development of T lymphocytes. In some case reports of atypical SCID patients elevated proportions of γδ T lymphocytes have been reported. However, it is unknown whether these γδ T cells modulate or reflect the patient's clinical phenotype. Read More

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http://dx.doi.org/10.1016/j.clim.2018.11.006DOI Listing
February 2019

Dynamic evolution of clonal composition and neoantigen landscape in recurrent metastatic melanoma with a rare combination of driver mutations.

J Invest Dermatol 2019 Feb 15. Epub 2019 Feb 15.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, UMR7104 CNRS; U1258 INSERM; Université de Strasbourg, Department of Functional Genomics and Cancer, 1 Rue Laurent Fries, 67404 Illkirch Cédex. France. Electronic address:

In melanoma, initiating oncogenic mutations in BRAF or NRAS are detected in premalignant lesions that accumulate additional mutations and genomic instability as the tumour evolves to the metastatic state. Here we investigate evolution of clonal composition and neoantigen landscape in an atypical melanoma displaying recurrent cutaneous lesions over a 6-year period without development of extra-cutaneous metastases. Whole exome sequencing of 4 cutaneous lesions taken over the 6-year period identified a collection of single nucleotide variants (SNVs) and small insertions and deletions (Indels) shared amongst all tumours along with progressive selection of subclones displaying fewer SNVs. Read More

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http://dx.doi.org/10.1016/j.jid.2019.01.027DOI Listing
February 2019

A phonological assessment test for child Greek.

Authors:
Elena Babatsouli

Clin Linguist Phon 2019 Feb 18:1-27. Epub 2019 Feb 18.

a Institute of Monolingual and Bilingual Speech , Chania , Greece.

This article advances a clinical tool for assessing typical and atypical phonological development in children speaking standard Modern Greek or Hellenic (ISO 639.1, el). The proposed tool develops a comprehensive test that is archetypical of the standard idiom and of predominant dialectal variations and seeks to be readily available for logopedics and language researchers of child Greek anywhere. Read More

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http://dx.doi.org/10.1080/02699206.2019.1569164DOI Listing
February 2019

Anemia Combined Significantly Increased High-Sensitivity C Reactive Protein and Lung Lesions Lead to the Diagnosis of Granulomatosis with Polyangiitis Proven by Lung Biopsy and Anti-neutrophil Cytoplasmic Antibody Test.

Clin Lab 2019 Jan;65(1)

Background: To report an atypical case misdiagnosed as lung abscess over the past 2 months, but persistent anemia combined with significantly increased hs-CRP and lung lesions indicated systemic lesion, which led to the diagnosis of granulomatosis with polyangiitis proven by lung biopsy and anti-neutrophil cytoplasmic antibody test (ANCA).

Methods: The complete blood count, hs-CRP, and anti-neutrophil cytoplasmic antibody (ANCA) test were performed. The pathology consultation for the lung biopsy was arranged. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180733DOI Listing
January 2019

Kawasaki disease: a comprehensive review.

Arch Med Sci Atheroscler Dis 2018 21;3:e41-e45. Epub 2018 Mar 21.

Department of Pediatrics, Robert Reid Cabral Children's Hospital affiliated to the University Iberoamericana UNIBE, School of Medicine, Santo Domingo, Dominican Republic.

Kawasaki disease is an acute systemic vasculitis that was first reported in 1961. Over the last 5 decades multiple papers have been published to further understand this disease. The diagnosis of Kawasaki disease is made based on the clinical findings. Read More

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http://dx.doi.org/10.5114/amsad.2018.74522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374576PMC

Clinico-Histomorphological and Immunohistochemical Profile of Anaplastic Pleomorphic Xanthoastrocytoma: Report of Five Cases and Review of Literature.

Int J Hematol Oncol Stem Cell Res 2018 Oct;12(4):265-272

Department of Neurosurgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Pleomorphic xanthoastrocytoma is a rare tumour of children and young adults, particularly for those with features of anaplasia. This retrospective study comprises five cases of anaplastic pleomorphic xanthoastrocytomas diagnosed over a period of 4 years in a tertiary care institute. A detailed clinicopathological and immunohistochemical profile of the tumours were noted from the hospital database. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375371PMC
October 2018

Unexplained Pancytopenia in a Patient with 5q35.2-q35.3 Microduplication Encompassing : A Case Report.

Int J Hematol Oncol Stem Cell Res 2018 Oct;12(4):260-264

Department of Laboratory Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Republic of Korea.

The 5q35.2-q35.3 duplication phenotype is characterized by growth delay, microcephaly, mental retardation and delayed bone aging. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375373PMC
October 2018

The Comparison Between Microwave and Autoclave as Antigen Retrieval Methods for Immunohistochemical Detection of CD15 and CD30 in Hodgkin's Lymphoma.

Iran J Pathol 2018 25;13(4):390-396. Epub 2018 Sep 25.

Pathology Laboratory, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background And Objective: Hodgkin's lymphoma is a potentially curable hematologic malignancy with difficulty in its diagnosis especially in atypical cases even in expert hands. Today, immunohistochemistry plays a significant role in the diagnosis of it especially applying the anti-CD15 and anti-CD30 antibodies. The negativity of CD15 can be reduced by antigen retrieval for methods. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358563PMC
September 2018

Atypical Flexibility in Dynamic Functional Connectivity Quantifies the Severity in Autism Spectrum Disorder.

Front Hum Neurosci 2019 1;13. Epub 2019 Feb 1.

Cognitive Brain Dynamics Lab, National Brain Research Centre, Manesar, India.

Resting-state functional connectivity (FC) analyses have shown atypical connectivity in autism spectrum disorder (ASD) as compared to typically developing (TD). However, this view emerges from investigating static FC overlooking the whole brain transient connectivity patterns. In our study, we investigated how age and disease influence the dynamic changes in functional connectivity of TD and ASD. Read More

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http://dx.doi.org/10.3389/fnhum.2019.00006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367662PMC
February 2019

gene knockout causes destruction of intestinal structure and animal death in mice.

World J Gastroenterol 2019 Feb;25(5):584-599

Department of Oncology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.

Background: Claudin-7, one of the important components of cellular tight junctions, is currently considered to be expressed abnormally in colorectal inflammation and colorectal cancer. However, there is currently no effective animal model to study its specific mechanism. Therefore, we constructed three lines of knockout mice using the Cre/LoxP system. Read More

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http://dx.doi.org/10.3748/wjg.v25.i5.584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371004PMC
February 2019

Bullous Pemphigoid with Atypical Skin Lesions and Acute Interstitial Nephritis: A Case Report and Focused Literature Review.

Am J Case Rep 2019 Feb 18;20:212-218. Epub 2019 Feb 18.

Department of Internal Medicine, Mount Sinai Hospital, Chicago, IL, USA.

BACKGROUND The hallmark of bullous pemphigoid (BP) is widespread tense blisters arising on normal or erythematous skin, often with marked pruritus, the diagnosis of which is confirmed by direct immunofluorescence (DIF). BP is an autoimmune process that can be induced, though rarely, by medications. Drug-induced BP often has atypical clinical presentation, which requires a good understanding of other dermatological conditions with similar presentations, in particular, bullous subtype of erythema multiforme. Read More

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http://dx.doi.org/10.12659/AJCR.911422DOI Listing
February 2019

Clinical differentiation of infectious mononucleosis that is caused by Epstein-Barr virus or cytomegalovirus: A single-center case-control study in Japan.

J Infect Chemother 2019 Feb 15. Epub 2019 Feb 15.

Department of General Medicine and Emergency Care, Toho University School of Medicine, Japan.

Introduction: Infectious mononucleosis (IM) is a common viral infection that typically causes fever, pharyngitis, and lymphadenopathy in young patients. The Epstein-Barr virus (EBV) is the most common cause of IM, followed by cytomegalovirus (CMV). Given that serological testing is associated with limitations regarding its accuracy, availability, and time to receive results, clinical differentiation based on symptoms, signs, and basic tests would be useful. Read More

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http://dx.doi.org/10.1016/j.jiac.2019.01.012DOI Listing
February 2019

Atypical Segmental Spinal Dysgenesis: Prenatal Diagnosis With Postpartum Short-Term Follow-Up.

J Obstet Gynaecol Can 2019 Feb 14. Epub 2019 Feb 14.

Department of Obstetrics and Gynecology, Rambam Health Care Campus, Haifa, Israel.

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http://dx.doi.org/10.1016/j.jogc.2018.07.012DOI Listing
February 2019