116,105 results match your criteria Atypical Antipsychotics : Milestones in Drug Therapy[Journal]


Fruit for thought: anaphylaxis to fruit pectin in foods.

J Allergy Clin Immunol Pract 2018 Dec 12. Epub 2018 Dec 12.

Division of Allergy & Immunology, Children's Hospital of Philadelphia, Philadelphia, PA; Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA.

Clinical Implications: Pectin is a structural heteropolysaccharide previously associated with occupational asthma and only rare accounts of allergy. Few case reports, however, suggest that pectin may contribute to atypical or idiopathic food reactions, particularly in patients with IgE-mediated allergy to tree nuts. Read More

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December 2018

Pleomorphic and atypical multinucleated giant cells in solid pseudopapillary neoplasm of pancreas: A diagnostic pitfall in cytology and a review of the literature.

Diagn Cytopathol 2018 Dec 14. Epub 2018 Dec 14.

Department of Laboratory Medicine, Cleveland Clinic, Cleveland, Ohio.

Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low-grade malignancy typically occurring in young women. Occasionally, these neoplasms present with pleomorphic to atypical multinucleated giant tumor cells which may mimic high-grade malignancy. Our patient is a 25-year-old male who presented with one year of intermittent epigastric pain. Read More

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December 2018

NRAS Q61R and BRAF G466A Mutations in Atypical Melanocytic Lesions Newly Arising in Advanced Melanoma Patients Treated with Vemurafenib.

J Cutan Pathol 2018 Dec 14. Epub 2018 Dec 14.

Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

Background: BRAF inhibition has improved overall survival in patients with BRAF mutant melanoma but this is associated with a range of known and predictable cutaneous side effects, including squamous cell carcinomas associated with RAS mutations.

Methods: We identified three severely dysplastic nevi, one atypical intraepidermal melanocytic proliferation, and four melanoma in situ lesions, newly arising in four patients undergoing treatment with vemurafenib. To characterize mutations in these atypical melanocytic lesions, we used a custom iPlex panel detecting 74 mutations in 13 genes known to play a role in melanoma pathogenesis. Read More

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December 2018

Simultaneous Loss of Both Atypical Protein Kinase C Genes in the Intestinal Epithelium Drives Serrated Intestinal Cancer by Impairing Immunosurveillance.

Immunity 2018 Dec 1. Epub 2018 Dec 1.

Cancer Metabolism and Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. Electronic address:

Serrated adenocarcinoma, an alternative pathway for colorectal cancer (CRC) development, accounts for 15%-30% of all CRCs and is aggressive and treatment resistant. We show that the expression of atypical protein kinase C ζ (PKCζ) and PKCλ/ι was reduced in human serrated tumors. Simultaneous inactivation of the encoding genes in the mouse intestinal epithelium resulted in spontaneous serrated tumorigenesis that progressed to advanced cancer with a strongly reactive and immunosuppressive stroma. Read More

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December 2018

Corrective wedge ostectomy for an atypical femoral procurvatum deformity stabilised with a supracondylar bone plate.

J S Afr Vet Assoc 2018 Dec 5;89(0):e1-e6. Epub 2018 Dec 5.

Translational Research and Animal Clinical Trial Study Group (TRACTS), U-Vet Veterinary Teaching Hospital, University of Melbourne.

Physeal fractures of the distal femur are among the most commonly encountered fractures in skeletally immature dogs. These fractures respond poorly to conservative management and thus early surgical reduction and stabilisation are recommended. A 7-month-old intact male Border collie presented with a history of chronic lameness. Read More

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December 2018

Integration of Satellite Data with High Resolution Ratio: Improvement of Spectral Quality with Preserving Spatial Details.

Sensors (Basel) 2018 Dec 13;18(12). Epub 2018 Dec 13.

Department of Remote Sensing, Photogrammetry and Imagery Intelligence, Institute of Geodesy, Faculty of Civil Engineering and Geodesy, Military University of Technology, 01-476 Warszawa, Poland.

Commonly used image fusion techniques generally produce good results for images obtained from the same sensor, with a standard ratio of spatial resolution (1:4). However, an atypical high ratio of resolution reduces the effectiveness of fusion methods resulting in a decrease in the spectral or spatial quality of the sharpened image. An important issue is the development of a method that allows for maintaining simultaneous high spatial and spectral quality. Read More

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December 2018

Psychological and electrophysiological indices of inattention in hoarding.

Psychiatry Res 2018 Dec 5;270:915-921. Epub 2018 Nov 5.

School of Psychology, University of New South Wales, Sydney, New South Wales 2052, Australia.

Individuals with elevated hoarding symptoms report elevated symptoms of ADHD and these symptoms are related to impaired daily functioning. Neuropsychological studies have found specific deficits in attention, and a recent review of attentional data from numerous hoarding studies concluded that inattention likely represents an etiological factor in hoarding, rather than a comorbidity. Our study aimed to examine which symptoms of ADHD, inattention or hyperactivity, are related to hoarding symptom severity, and whether individuals with hoarding symptoms display a neurophysiological marker of poor attention (Theta/Beta Ratio; THBR) that might explain these associations. Read More

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December 2018

Anomalous Bodily Maps of Emotions in Schizophrenia.

Schizophr Bull 2018 Dec 14. Epub 2018 Dec 14.

Department of Psychology, Vanderbilt University, Nashville, TN.

Objective: Embodied emotions arise from interoceptive and somatosensory processes, and are essential to the development of a stable sense of self. Emotional embodiment is therefore inherently interwoven with our sense of bodily self-awareness, and allows us to navigate complex social situations. Given that the core feature of schizophrenia (SZ) is characterized by the presence of bodily self-disturbances and social-emotional deficits, we hypothesized that embodiment of emotion would be disrupted in SZ. Read More

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December 2018
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MiR-23a-3p acts as an oncogene and potential prognostic biomarker by targeting PNRC2 in RCC.

Biomed Pharmacother 2018 Dec 11;110:656-666. Epub 2018 Dec 11.

Department of Urology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China; Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China. Electronic address:

Background: Renal cell carcinoma (RCC) is a most common kidney malignancy, with atypical symptoms in the early stage and poor outcome in the late stage. Recently, emerging evidence revealed that some miRNAs play an essential role in the tumorigenesis and progression of RCC. Therefore, the aim of this study is that understand the detailed molecular mechanism of miR-23a-3p in RCC and identify its potential clinical value. Read More

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December 2018
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The IRS/PI3K/Akt signaling pathway mediates olanzapine-induced hepatic insulin resistance in male rats.

Life Sci 2018 Dec 11. Epub 2018 Dec 11.

Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; Endocrinology and Metabolism Group, Sydney Institute of Health Sciences, Sydney Institute of Traditional Chinese Medicine, Sydney, NSW 2000, Australia. Electronic address:

Aims: Chronic treatment with antipsychotics, especially most of atypical ones, leads to development of metabolic abnormalities. Olanzapine is an atypical antipsychotic widely used in the treatment of schizophrenia and bipolar disorder. The mechanisms underlying olanzapine-induced metabolic adverse effects in the liver, however, remain unclear. Read More

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December 2018
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Atypical Prenatal Ultrasound Presentation and Neuropathological Findings in a Neonate With Alpha Thalassemia Major: A Case Report.

Pediatr Dev Pathol 2018 Dec 14:1093526618817655. Epub 2018 Dec 14.

1 Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Canada.

Alpha thalassemia major is a hemoglobinopathy caused by the inactivation or deletion of all 4 α-globin alleles. We describe a case of α-thalassemia major with atypical ultrasound and neuropathological findings. The mother had her first prenatal visit at 27 4/7 gestational weeks. Read More

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December 2018

Issues in the Differential Diagnosis of Uterine Low-grade Endometrioid Carcinoma, Including Mixed Endometrial Carcinomas: Recommendations from the International Society of Gynecological Pathologists.

Int J Gynecol Pathol 2019 Jan;38 Suppl 1:S25-S39

Pathology Department, University of California San Francisco, San Francisco, California (J.T.R.) Department of Pathology and Laboratory Medicine, Vancouver General Hospital and University of British Columbia, Vancouver, British Columbia, Canada (C.B.G.) Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (A.M.) Department of Pathology, University Hospital Arnau de Vilanova and Department of Pathology, University Hospital de Bellvitge, University of Lleida, IRBLLEIDA, IDIBELL, CIBERONC, Spain (X.M.G.) Department of Pathology, New York University Langone Medical Center, New York, New York (K.M.) Department of Pathology, Brigham and Women's Hospital (G.L.M.) Pathology Department, Massachusetts General Hospital (E.O.), Boston, Massachusetts Pathology Department, Yale New Haven Hospital, New Haven, Connecticut (V.P.) Department of Pathology, Johns Hopkins Medical Institutions (B.M.R.) Department of Pathology, University of Maryland School of Medicine (P.S.), Baltimore, Maryland Department of Histopathology, King Edward Memorial Hospital and School for Women's and Infants' Health, University of Western Australia, Perth, Australia (C.J.R.S.) Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland, UK (W.G.M.).

This article provides practical recommendations developed from the International Society of Gynecological Pathologists Endometrial Carcinoma Project to address 4 issues that may arise in the diagnosis of uterine corpus low-grade endometrioid carcinoma: (1) The distinction between atypical hyperplasia and low-grade endometrioid carcinoma. (2) The distinction between low-grade endometrioid carcinoma and serous carcinoma. (3) The distinction between corded and hyalinized or spindle cell variants of low-grade endometrioid carcinoma and carcinosarcoma. Read More

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January 2019

Use of Buprenorphine-Naloxone in the Treatment of Tianeptine Use Disorder.

J Addict Med 2018 Dec 13. Epub 2018 Dec 13.

Spectrum Health, Center for Integrative Medicine, Grand Rapids, MI (PT); Boston University Department of Medicine, Section of General Internal Medicine, Clinical Addiction Research and Education Unit, School of Medicine & Boston Medical Center, Boston, MA (AYW).

: Tianeptine is an atypical antidepressant which exerts an opioid-like effect on the μ-opioid receptor. There is well documented intentional misuse and addiction to tianeptine in Europe, and this is increasingly being seen in the United States. We presented a case of buprenorphine/naloxone successfully being used to aid in cessation and subsequent abstinence from tianeptine after years of use. Read More

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December 2018

Drug Susceptibility of Non-tuberculous Strains of Isolated from Birds from Poland.

Pol J Microbiol 2018 ;67(4):487-492

Department of Pathology and Veterinary Diagnostics, Warsaw University of Life Sciences , Warsaw , Poland.

Mycobacterioses are a constant problem in backyard poultry, as well as pet birds. To date, no evidence of direct transmission of atypical bacilli between humans has been demonstrated, but it cannot be ruled out that sick animals can be a source of infection for people in their environment. The aim of the study was to identify mycobacteria isolated from birds with diagnosed mycobacteriosis and to determine the susceptibility of mycobacterial isolates from these animals to antituberculous drugs most commonly used in the treatment of mycobacterial infections in humans. Read More

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January 2018
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[Analysis of features of ocular tilt reaction for patients with vestibular neuritis].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jul;32(14):1091-1094

Department of Ophthalmology, Guangxi Zhuang Autonomous Region People's Hospital.

To analyze the clinical characteristics of ocular tilt reaction in vestibular neuritis patients and discuss its value to the diagnosis of vestibular neuritis.Thirty-five patients with vestibular neuritis confirmed between January 2016 and March 2018 underwent bedside vestibular function physical examination including nystagmus, head impulse test(HIT),head shaking nystagmus(HSN), ocular tilt reaction(OTR), Romberg sign, Fukuda stepping. All patients underwent head CT scan and brain MRI scan + DWI to exclude bleeding and infarction. Read More

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A giant and atypical port-wine stain with facial deformity.

J Dtsch Dermatol Ges 2018 Dec 14. Epub 2018 Dec 14.

Servicio de Dermatología Hospital Universitario "Dr. José E. González", Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, México.

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December 2018

Genotype, extrapyramidal features and severity of variant Ataxia-Telangiectasia.

Ann Neurol 2018 Dec 14. Epub 2018 Dec 14.

Ataxia Telangiectasia Service, Respiratory Support and Sleep Centre, Papworth Hospital. Papworth Everard, Cambridge, CB23 3RE, UK.

Objective: Variant Ataxia-Telangiectasia is caused by mutations that allow some retained ATM kinase activity. Here, we describe the clinical features of the largest established cohort of individuals with variant Ataxia-Telangiectasia and explore genotype-phenotype correlations.

Methods: Cross-sectional data were collected retrospectively. Read More

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December 2018
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Molecular cloning and comparative analysis of transcripts encoding chemosensory proteins from two plant bugs, Lygus lineolaris and Lygus hesperus.

Insect Sci 2018 Dec 13. Epub 2018 Dec 13.

USDA-ARS Arid Land Agricultural Center, Maricopa, AZ, 85138, USA.

Chemosensory proteins (CSPs) are soluble carrier proteins typically characterized by a six-helix bundle structure joined by two disulfide bridges and a conserved Cys spacing pattern (C1-X -C2-X -C3-X -C4). CSPs are functionally diverse with reported roles in chemosensation, immunity, development, and resistance. To expand our molecular understanding of CSP function in plant bugs, we used recently developed transcriptomic resources for Lygus lineolaris and Lygus hesperus to identify 17 and 14 CSP-like sequences, respectively. Read More

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December 2018

Regional multimodal relationships between tau, hypometabolism, atrophy, and fractional anisotropy in atypical Alzheimer's disease.

Hum Brain Mapp 2018 Dec 13. Epub 2018 Dec 13.

Department of Radiology, Mayo Clinic, Rochester, Minnesota.

Alzheimer's disease (AD) can present with atypical clinical forms where the prominent domain of deficit is not memory, that is, atypical AD. Atypical AD patients show cortical atrophy on MRI, hypometabolism on [ F]fluorodeoxyglucose (FDG) PET, tau uptake on [ F]AV-1451 PET, and white matter tract degeneration on diffusion tensor imaging (DTI). How these disease processes relate to each other locally and distantly remains unclear. Read More

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December 2018

Age but no sex effects on subareas of the amygdala.

Hum Brain Mapp 2018 Dec 13. Epub 2018 Dec 13.

School of Psychology, University of Auckland, Auckland, New Zealand.

The amygdala, an anatomical composite of several nuclei that have been grouped anatomically and functionally into three major subareas, has been reported to decrease in size with increasing age and to differ in size between male and female brains. However, findings are rather inconsistent across existing studies, possibly reflecting differences in the cohorts examined or the approaches chosen to define and measure the dimensions of the amygdala. Here, we investigated possible effects of age and sex on the amygdala as well as age-by-sex interactions in 100 healthy subjects (50 men/50 women) aged 18-69 years. Read More

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December 2018
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Determination of Olanzapine for Therapeutic Drug Monitoring in Schizophrenia Patients by LC/MS Method.

Biomed Chromatogr 2018 Dec 13:e4468. Epub 2018 Dec 13.

Department of Psychiatry, İzmir Katip Çelebi University, Ataturk Training and Research Hospital, İzmir, Turkey.

Olanzapine is an atypical antipsychotic drug from thienobenzodiazepine family which displays efficacy in patients with schizophrenia and related psychoses. A novel LC/MS method was developed and validated for determination of olanzapine in schizophrenia patients plasma. A liquid-liquid extraction procedure carried out by using 5 mL diethyl ether-diisopropyl ether mixture (1:1, v/v). Read More

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December 2018

Histopathologic correlation of high-risk MelaFind lesions: a 3-year experience from a high-risk pigmented lesion clinic.

Int J Dermatol 2018 Dec 13. Epub 2018 Dec 13.

Dermatology and Plastic Surgery Institute, Cleveland Clinic, Cleveland, OH, USA.

Background: A significant number of pigmented lesions are biopsied to rule out melanoma, but most will be benign. MelaFind is a highly sensitive, noninvasive computer-assisted system to aid in clinical diagnosis of melanoma.

Methods: A total of 140 high-risk patients were followed by one expert dermatologist. Read More

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December 2018
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Grasping the weight cut-off for anorexia nervosa in children and adolescents.

Int J Eat Disord 2018 Dec 13. Epub 2018 Dec 13.

Center for Child and Adolescent Psychiatry, Aarhus University Hospital, Risskov, Denmark.

Objective: The Diagnostic and Statistical Manual of Mental Disorders 5 suggests the 5th age-adjusted body mass index (BMI) percentile as the numeric cut-off for anorexia nervosa (AN) in children and adolescents. We aimed to investigate the degree to which the 5th age-adjusted percentile as the numeric cut-off for AN in youths reflects the clinical population of patients accepted for treatment.

Method: From a specialized eating disorder clinic, 305 patients with AN below 18 years of age were grouped according to age-adjusted BMI percentiles [below the 5th (low), above the 10th (high), and between the 5th and the 10th (medium)]. Read More

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December 2018

Neuroanatomical correlates of sensory deficits in children with neonatal arterial ischemic stroke.

Dev Med Child Neurol 2018 Dec 12. Epub 2018 Dec 12.

Department of Neurology, University of California, San Francisco, CA, USA.

Aim: Our aim was to characterize the sensory processing outcome following neonatal arterial ischemic stroke (NAIS) and identify neuroanatomical correlates of abnormal sensory processing.

Method: We evaluated children with NAIS longitudinally at 12 months, 18 months, and/or 30 months in areas of cognitive, motor, and language development. We gathered sensory processing data using the Sensory Profile-2 Caregiver Questionnaire. Read More

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December 2018

Atypical Film-Forming Behavior of Soluble Tetra-3-Nitro-Substituted Copper Phthalocyanine.

Chemphyschem 2018 Dec 12. Epub 2018 Dec 12.

Institute of Solution Chemistry Russian Academy of Sciences, I-8, Akademicheskaya Str., 1, 153045, Ivanovo, RUSSIAN FEDERATION.

Thin films of metal phthalocyanines (MPc) are known to exhibit excellent physical properties but poorly controlled morphologies. Therefore, the present work seeks to understand the film growth mechanism of a model compound for potentially usable MPc, specifically, copper tetra(3-nitro-5-tert-butyl)phthalocyanine (CuPc*). The Langmuir-Schaefer (LS) technique was applied to prepare a series of CuPc* films under different processing conditions. Read More

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December 2018

Tramadol dispensing patterns and trends in Canada, 2007-2016.

Pharmacoepidemiol Drug Saf 2018 Dec 12. Epub 2018 Dec 12.

Centre for Applied Research in Mental Health and Addiction, Faculty of Health Sciences, Simon Fraser University, Vancouver, Canada.

Purpose: Opioid use and associated mortality and morbidity have substantially increased in Canada, which recent interventions have aimed to reduce. Tramadol is an atypical prescription-only (but unscheduled under Canada's narcotics law) opioid analgesic and not subject to controls for other (eg, strong) opioids. Given experiences in different jurisdictions, tramadol may have been increasingly dispensed as a "substitute" drug during a period with increasingly restrictive controls for other (scheduled) opioids. Read More

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December 2018

Atypical actinobacillosis affecting hind limbs and lungs in a single beef cattle herd.

J Vet Intern Med 2018 Dec 12. Epub 2018 Dec 12.

Clinic for Ruminants, Nantes, France.

Actinobacillosis usually is a sporadic infection that affects the tongue in cattle ("wooden tongue") with possible spread to the digestive tract. Two 4-year-old Rouge-des-Prés cows from a single French beef herd were referred for chronic (2-6 months) swelling and cutaneous nodules in the distal hind limbs. In addition to cutaneous signs, physical examination disclosed cachexia, lameness, lymphadenitis of the hind limbs, and pneumonia in both cows. Read More

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December 2018
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Chikungunya Virus: History, Geographic Distribution, Clinical Picture, and Treatment.

P R Health Sci J 2018 Dec;37(4):187-194

Third-year medical student, University of Puerto Rico Medical Sciences Campus, San Juan, PR.

Chikungunya fever (CHIKF) is a re-emerging mosquito-borne disease caused by a virus endemic to Africa and Asia. Due to the ease with which its vectors propagate, the virus has spread to India and Europe, and more recently it arrived to the Caribbean, eventually extending into North, Central, and South America. According to the World Health Organization (WHO), the most common clinical manifestations are abrupt fever, polyarthralgia, headache, maculopapular rash, myalgia, and nausea/vomiting. Read More

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December 2018

Genetic analysis reveals functions of atypical polyubiquitin chains.

Elife 2018 Dec 14;7. Epub 2018 Dec 14.

Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, United States.

Although polyubiquitin chains linked through all lysines of ubiquitin exist, specific functions are well-established only for lysine-48 and lysine-63 linkages in Saccharomyces cerevisiae. To uncover pathways regulated by distinct linkages, genetic interactions between a gene deletion library and a panel of lysine-to-arginine ubiquitin mutants were systematically identified. The K11R mutant had strong genetic interactions with threonine biosynthetic genes. Read More

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December 2018

Triventricular pacing improved dyssynchrony in heart failure patient with right-bundle branch block and left anterior fascicular block.

J Cardiol Cases 2014 Apr 5;9(4):158-161. Epub 2014 Feb 5.

Cardiovascular Division, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

The present case report describes a 53-year-old man with drug-resistant heart failure. Electrocardiogram showed complete right-bundle branch block and left anterior fascicular block. A cardiac resynchronization therapy (CRT) device was implanted in him because echocardiography showed obvious left ventricular dyssynchrony between septal and lateral walls. Read More

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Primary pericardial synovial sarcoma: A case report and literature review.

J Cardiol Cases 2014 Jan 13;9(1):40-43. Epub 2013 Dec 13.

Department of Radiotherapy-Oncology, UHC Ibn Rochd, Casablanca, Morocco.

Primary pericardial synovial sarcoma is extremely rare, with few published cases in the literature. We report the case of an adolescent aged 13 years with primary pericardial synovial sarcoma discovered during tamponade, confirmed by molecular biology, and for whom treatment combined radiosurgery and adjuvant chemotherapy. The particularity of the case we are reporting stems from the young age of our patient (13 years) as well as the duration of remission, which is quite long (21 months) prior to a superior mediastinal relapse compared to cases reported in the literature. Read More

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January 2014
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Atypical type of dual left anterior descending coronary artery.

J Cardiol Cases 2013 Jul 15;8(1):e39-e41. Epub 2013 Apr 15.

Department of Cardiology, School of Medicine, Bulent Ecevit University, Kozlu 67600, Zonguldak, Turkey.

Dual left anterior descending coronary artery (LAD) is a rare coronary anomaly and is divided into six subgroups in the literature according to the origin and course of the short and long branches of the anomalous artery. We present two distinct cases of dual LAD which are distinguished by two branches of equal length from their counterparts in the literature. < In our cases a novel dual LAD variant is presented with two main branches of equal length and reaches the cardiac apex. Read More

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Angiographic right heart hypermobility as a sign of non-cardiac pathology in the setting of ST elevation.

J Cardiol Cases 2013 Jul 17;8(1):e36-e38. Epub 2013 Apr 17.

Lancashire Cardiac Centre, Blackpool Victoria Hospital, Whinney Heys Rd, Blackpool, Lancashire FY3 8NR, UK.

Esophageal perforation (Boerhaave's syndrome) is a severe life-threatening disorder. Diagnosis and treatment are often delayed due to the wide variety of presenting symptoms. This case report details an unusual presentation of Boerhaave's syndrome in a 48-year-old man mimicking an acute anterior myocardial infarction. Read More

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A case of takotsubo cardiomyopathy leading to the diagnosis of myasthenia gravis.

J Cardiol Cases 2012 Nov 28;6(5):e141-e144. Epub 2012 Aug 28.

Department of Surgery, Sagamihara Kyodo Hospital, Japan.

A 52-year-old woman presenting with shortness of breath and having no related past medical history was diagnosed with takotsubo cardiomyopathy. However, she revealed respiratory failure atypical with takotsubo cardiomyopathy. We diagnosed myasthenia gravis with myasthenic crisis by acetylcholine receptor-binding antibody titer with mediastinal tumor. Read More

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November 2012

Heparin-induced thrombocytopenia associated with polycythemia vera during the treatment of acute coronary syndrome.

J Cardiol Cases 2016 Aug 28;14(2):52-55. Epub 2016 Apr 28.

Department of Cardiology, Gifu Prefectural General Medical Center, Gifu City, Gifu, Japan.

Here, we report a case of heparin-induced thrombocytopenia (HIT) associated with polycythemia vera (PV) during the treatment of acute coronary syndrome. An 84-year-old woman with pre-existing PV had an acute myocardial infarction and developed HIT after using heparin. An additional myocardial infarction was caused by HIT, and caused marked damage to her cardiac function. Read More

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A new variation of dual left anterior descending coronary artery.

J Cardiol Cases 2016 Jul 31;14(1):26-28. Epub 2016 Mar 31.

Division of Cardiovascular Health and Disease, Department of Internal Medicine University of Cincinnati, Cincinnati, OH, USA.

A 63-year-old male with past medical history of type II diabetes mellitus, hypertension, hyperlipidemia, stroke, and permanent pacemaker implant for poor chronotropic response to exercise underwent coronary computed tomography angiography (CCTA) for worsening atypical chest pain. The patient had normal myocardial perfusion by nuclear stress testing 3 months prior to this test. A rare variation of dual left anterior descending coronary artery (LAD) was identified by CCTA and subsequent coronary angiography confirmed a dual LAD and revealed no significant stenosis of the coronary arteries. Read More

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Transient semi-circumferential mid-ventricular ballooning: An atypical variant of takotsubo cardiomyopathy.

J Cardiol Cases 2016 Jul 1;14(1):21-23. Epub 2016 Apr 1.

Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.

Although apical ballooning is the most common morphological type of takotsubo cardiomyopathy, variants have been reported. Several case reports have demonstrated focal takotsubo cardiomyopathy. Most cases had left ventricular wall motion abnormality in the anterolateral segment. Read More

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Crohn's colitis-induced myocarditis.

J Cardiol Cases 2016 Jul 7;14(1):4-7. Epub 2016 Apr 7.

Division of Cardiology, Northwestern Memorial Hospital, Chicago, IL, USA.

Myocarditis can be idiopathic or arise in response to numerous systemic insults. Myocarditis occurring in the setting of an exacerbation of inflammatory bowel disease is a rare extra-intestinal manifestation of both ulcerative and Crohn's-related colitis. Here, we present a unique case of a 56-year-old female patient presenting with an acute Crohn's colitis flare that was eventually complicated by myocarditis. Read More

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Systemic and pulmonary artery aneurysms in incomplete Kawasaki disease.

J Cardiol Cases 2016 Jun 15;13(6):185-188. Epub 2016 Mar 15.

Division of Pediatric Cardiology, Le Bonheur Children's Hospital, University of Tennessee Health Science Center, Memphis, TN, USA.

Kawasaki disease (KD) is a systemic vasculitis that can cause coronary artery aneurysms (CAA) in up to 25% if left untreated. Rarely, aneurysms of systemic arteries of all sizes have been reported to occur. The incidence of systemic artery aneurysms (SAA) with typical KD can be as high as 2. Read More

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Pleuropericarditis complicated by a pericardial cyst.

J Cardiol Cases 2015 Nov 27;12(5):156-158. Epub 2015 Jul 27.

Department of Medicine, Rutgers University, New Jersey Medical School, Newark, NJ, USA.

We report the case of a 36-year-old woman with a recent upper respiratory illness who presented with chest pressure, lasting for five days, which improved with leaning forward. Physical examination and laboratory studies were unremarkable. Chest computed tomography scan revealed a 6. Read More

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November 2015

Cardiac cephalgia: A headache of the heart.

J Cardiol Cases 2015 May 27;11(5):139-141. Epub 2015 Feb 27.

Department of Cardiology, Dhaka Medical College, Dhaka, Bangladesh.

Atypical presentations of common diseases are often difficult to identify in time, nonetheless necessary, especially in cases of diseases like ischemic heart disease (IHD) which otherwise may progress into irreversible stage and ultimately, fatality, in the absence of timely administered medical treatment. We report a case of a 51-year-old male, presenting initially with only headache as the sole symptom, who later was diagnosed with severe coronary artery disease, and the symptoms resolved completely after coronary angioplasty with stenting. < Atypical presentations, such as headache, can be more prevalent in ischemic heart disease (IHD) than was thought of, so awareness of the possibility of IHD while assessing headache and further study to see actually how commonly headache is associated with IHD are necessary. Read More

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Solitary right ventricular metastasis of endometrial adenocarcinoma.

J Cardiol Cases 2015 Jan 14;11(1):32-34. Epub 2014 Nov 14.

Department of Medicine - Cardiology, University of Bonn, Bonn, Germany.

A woman presented with a solitary cardiac metastasis 5 months after curative surgery for endometrial adenocarcinoma (FIGO IB). The tumor was deemed inoperable and palliative ambulatory chemotherapy was initiated. We aimed at a palliative reduction of tumor mass after chemotherapy and atypical vascularization of the metastasis was demonstrated by coronary angiography. Read More

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January 2015

Multiple forms of atypical atrioventricular nodal reentrant tachycardia with different right- and left-sided retrograde slow pathways.

J Cardiol Cases 2010 Oct 16;2(2):e111-e114. Epub 2010 Jun 16.

Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan.

A 56-year-old man was admitted for the treatment of supraventricular tachycardia. After successful ablation of the left concealed accessory pathway, four fast-slow forms of atrioventricular nodal reentrant tachycardia associated with different right- and left-sided retrograde slow pathways were induced. The locations of retrograde slow pathway were observed at the left inferior paraseptum, left mid-septum, right inferior paraseptum, and coronary sinus ostium, respectively. Read More

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October 2010

Rapid diagnosis of prosthetic valve endocarditis from Janeway lesions in a transcatheter aortic valve implantation patient.

J Cardiol Cases 2016 Feb 30;13(2):63-66. Epub 2015 Nov 30.

Department of Cardiology and Catheterization Laboratory, Shonan Kamakura General Hospital, Kamakura, Japan.

Percutaneous transcatheter aortic valve implantation (TAVI), first introduced in 2002, is a viable solution for previously inoperable or high-risk patients with aortic stenosis, providing the benefit of valve replacement without the associated risks of surgery. When these patients develop prosthetic valve endocarditis (PVE), management is complicated, owing to their often, atypical presentations and baseline comorbidities. Moreover, it is often difficult to detect vegetations in such patients, even with transesophageal echocardiography. Read More

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February 2016

Pushing and loss of elastic fibers are highly specific for melanoma and rare in melanocytic nevi.

Arch Dermatol Res 2018 Dec 13. Epub 2018 Dec 13.

Dermatology Department, Inselspital Bern University Hospital, University of Bern, Freiburgstrasse, 3010, Bern, Switzerland.

The histopathological differentiation of melanocytic nevi from malignant melanoma (MM) is based on well-known criteria, and is straightforward in the vast majority of cases. However, there are few cases of melanocytic lesions (ML), the diagnosis of which is very challenging or even impossible. Here we have studied several morphological characteristics with particular focus on elastic fibers (EF) to identify features, helpful for the distinction between nevi and MM. Read More

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December 2018
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A Systematic Review of Atypical Teratoid Rhabdoid Tumor in Adults.

Front Oncol 2018 28;8:567. Epub 2018 Nov 28.

Division of Neuropathology, University of Alberta Hospital, Edmonton, AB, Canada.

Atypical teratoid/rhabdoid tumor in adults is a relatively rare malignant neoplasm. It is characterized by the presence of rhabdoid cells in combination with loss of either the INI1 or BRG1protein from the tumor cells. A systematic review was conducted using MEDLINE using the terms "atypical teratoid rhabdoid tumor" AND "adult. Read More

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November 2018
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Identification of PD-L2, B7-H3 and CTLA-4 immune checkpoint proteins in genetic subtypes of meningioma.

Oncoimmunology 2019 5;8(1):e1512943. Epub 2018 Sep 5.

Project neuroArm, Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Meningioma is the most common brain tumor in adults. Surgical resection remains the primary treatment. No chemotherapy exists. Read More

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September 2018
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Radiotherapy-associated intra-abdominal angiosarcoma after prostatic adenocarcinoma: Case reports.

Mol Clin Oncol 2018 Dec 5;9(6):592-596. Epub 2018 Oct 5.

Pathology Service, University Hospital of Saint Joan, Faculty of Medicine, IISPV, 'Rovira i Virgili' University, Reus, 43204 Tarragona, Spain.

Angiosarcoma is a rare soft tissue neoplasm, which accounts for <1% of all soft tissue tumours. It has been previously reported that the incidence rate of angiosarcomas increases following radiotherapy. The present study reports two cases of intra-abdominal angiosarcoma associated with previous radiotherapy treatment. Read More

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December 2018
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Atypical type of familial Mediterranean fever: An underdiagnosed cause of chronic aseptic meningitis.

Neurol Clin Neurosci 2018 Nov 24;6(6):191-193. Epub 2018 Sep 24.

Department of Neurology Shin-yurigaoka General Hospital Kanagawa Japan.

We report an atypical case of familial Mediterranean fever (FMF) concomitant with chronic aseptic meningitis. The patient experienced fever, abdominal and back pain because of serositis, and headache because of aseptic meningitis for 4 weeks. Blood examinations revealed increased white blood cells and serum amyloid A level. Read More

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November 2018
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