125,222 results match your criteria Atypical Antipsychotics : Milestones in Drug Therapy[Journal]


Reflection on lower rates of COVID-19 in children: Does childhood immunizations offer unexpected protection?

Med Hypotheses 2020 May 15;143:109842. Epub 2020 May 15.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.

The incidence of COVID-19 in children and teenagers is only about 2% in China. Children had mild symptoms and hardly infected other children or adults. It is worth considering that children are the most vulnerable to respiratory pathogens, but fatal SARS-like virus had not caused severe cases among them. Read More

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http://dx.doi.org/10.1016/j.mehy.2020.109842DOI Listing

Predictors of 1-year rehospitalization in inpatients with bipolar I disorder treated with atypical antipsychotics.

Int Clin Psychopharmacol 2020 May 25. Epub 2020 May 25.

Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Objectives: Bipolar disorder (BPD) is debilitating disorder, and patients can experience multiple relapses and subsequent hospitalizations. Since pharmacotherapy is the mainstay of treatment for patients with BPD, investigations on the effects of atypical antipsychotics (AAP) on reducing rehospitalization risk are crucial. The objective of study is to explore predictors of 1-year rehospitalization in patients with bipolar I disorder treated with AAP. Read More

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http://dx.doi.org/10.1097/YIC.0000000000000318DOI Listing

A rare case of Actinomyces skin and soft tissue infection in an end-stage kidney disease patient with a review of the literature.

Hemodial Int 2020 May 26. Epub 2020 May 26.

Warren Alpert Medical School of Brown University, Providence, RI, USA.

End-stage kidney disease (ESKD) patients are a commonly overlooked immunocompromised population that places them at risk for rare infections. We describe the case of a 78-year-old man with a history of ESKD managed with thrice weekly in-center hemodialysis who had a prolonged episode of left elbow pain and drainage and was eventually found to have a skin and soft tissue infection from Actinomyces radingae. We review the bacteriology of Actinomyces spp. Read More

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http://dx.doi.org/10.1111/hdi.12843DOI Listing

Spurious, marked leukocytosis in 2 cats with Heinz body hemolytic anemia.

Vet Clin Pathol 2020 May 26. Epub 2020 May 26.

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN, USA.

Two domestic shorthair cats were presented with anorexia and dehydration following ingestion of caramelized onions. Shared key findings from a CBC (ADVIA 2120), serum biochemistry, and urinalysis included a spurious, marked leukocytosis with discordant basophil (BASO) channel and peroxidase channel WBC counts, normal manual leukocyte counts, mild, non-regenerative anemia with discrepancies between automated and manual reticulocyte counts, an abundance of large Heinz bodies (HBs), and highly irregular scattergrams. Case 1 also demonstrated a markedly elevated mean corpuscular hemoglobin concentration (MCHC) and discrepancies between RBC hemoglobin indices. Read More

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http://dx.doi.org/10.1111/vcp.12860DOI Listing

Atypical Topographical Organization of Global Form and Motion Processing in 5-Month-Old Infants at Risk for Autism.

J Autism Dev Disord 2020 May 26. Epub 2020 May 26.

Uppsala Child & Babylab, Department of Psychology, Uppsala University, Box 1225, 75142, Uppsala, Sweden.

Research indicates that individuals with autism spectrum disorder (ASD) are superior at local processing while the integration of local features to global percepts is reduced. Here, we compared infants at familiar risk for ASD to typically developing infants in terms of global coherence processing at 5 months of age, using steady state visually evoked potentials (SSVEP). We found a different topographical organization for global form and motion processing in infants at risk (n = 50) than in controls (n = 23). Read More

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http://dx.doi.org/10.1007/s10803-020-04523-2DOI Listing

Atypical femoral hernia called Laugier's hernia: clinical features, radiological findings, and management at a single center.

Langenbecks Arch Surg 2020 May 24. Epub 2020 May 24.

Department of Surgery, Division of Gastroenterological and Hepatobiliary Surgery and Organ Transplantation, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.

Purpose: Laugier's hernia is a rare clinical entity compared with a typical femoral hernia. Therefore, the clinical features, radiological findings, and appropriate treatment strategies remain largely unclear. In this study, we present 15 Laugier's hernia cases. Read More

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http://dx.doi.org/10.1007/s00423-020-01897-wDOI Listing

First application of intraoperative MRI of the liver during ALPPS procedure for colorectal liver metastases.

Langenbecks Arch Surg 2020 May 26. Epub 2020 May 26.

Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Dresden, Germany.

Purpose: Intraoperative detection of intrahepatic lesions can be demanding. The use of preoperative contrast-enhanced magnetic resonance imaging (MRI) or computer tomography (CT) combined with intraoperative ultrasound of the liver is state of the art. Near totally regressed colorectal liver metastases (CRLM) after neoadjuvant chemotherapy or nodules in severely altered liver tissue as steatosis or cirrhosis are often hard to detect during the operative procedure. Read More

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http://dx.doi.org/10.1007/s00423-020-01890-3DOI Listing

Diagnostic Capability of Next-Generation Sequencing Fusion Analysis in Identifying a Rare CASE of Associated Anaplastic Large Cell Lymphoma.

Front Oncol 2020 8;10:730. Epub 2020 May 8.

Department of Pathology and Laboratory Medicine, NorthShore University HealthSystem, Evanston, IL, United States.

Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma (ALCL) is a rare T-cell neoplasm, accounting for approximately 3% of adult non-Hodgkin lymphomas. Although NPM1 is the most common fusion partner with ALK, many others have been described, necessitating break-apart FISH studies for confirmation of the diagnosis. TNF receptor-associated factor 1 (TRAF1) is a rare ALK partner that is thought to confer a worse prognosis in patients. Read More

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http://dx.doi.org/10.3389/fonc.2020.00730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225296PMC

On the Edge Between Digital and Physical: Materials to Enhance Creativity in Children. An Application to Atypical Development.

Front Psychol 2020 8;11:755. Epub 2020 May 8.

Natural and Artificial Cognition Laboratory, Department of Humanistic Studies, University of Naples "Federico II", Naples, Italy.

The 4 P's creativity model (person, process, press, and product) underlines how creativity is strongly connected with the materials employed to conceive and realize a creative outcome. As a multiform construct, it invites a wide variety of approaches to the study of it. One of the most promising ways to address this issue is to connect it with cognitive development and related educational pathways, as creativity can be enhanced and stimulated in every child, leading to an improvement both at personal and societal level. Read More

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http://dx.doi.org/10.3389/fpsyg.2020.00755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227372PMC

Comparative Efficacy and Acceptability of Pharmaceutical Management for Adults With Post-Traumatic Stress Disorder: A Systematic Review and Meta-Analysis.

Front Pharmacol 2020 8;11:559. Epub 2020 May 8.

Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan, China.

The current clinical guidelines on post-traumatic stress disorder (PTSD) recommend selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) of drugs. However, there is uncertainty about the efficacy of other drugs and selecting which treatments work best for which patients. This meta-analysis evaluated efficacy and acceptability of pharmaceutical management for adults with PTSD. Read More

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http://dx.doi.org/10.3389/fphar.2020.00559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225303PMC

Clinical and Genetic Aspects of CADASIL.

Front Aging Neurosci 2020 7;12:91. Epub 2020 May 7.

Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a hereditary cerebral small vessel disease caused by mutations in , is characterized by recurrent stroke without vascular risk factors, mood disturbances, and dementia. MRI imaging shows cerebral white matter (WM) hyperintensity, particularly in the external capsule and temporal pole. Missense mutations related to a cysteine residue in the 34 EGFr on the NOTCH3 extracellular domain (N3ECD) are a typical mutation of CADASIL. Read More

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http://dx.doi.org/10.3389/fnagi.2020.00091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224236PMC

Tiny but mighty: use of next generation sequencing on discarded cytocentrifuged bile duct brushing specimens to increase sensitivity of cytological diagnosis.

Mod Pathol 2020 May 26. Epub 2020 May 26.

Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

Bile duct brushing (BDB) is used to evaluate pancreatobiliary lesions as it widely samples lesions with a low complication rate. Cytological evaluation of BDB is a specific but insensitive test. There is limited literature on the use of post-cytocentrifuged (PCC) samples, which are usually discarded, for next-generation sequencing (NGS) as an adjunct to cytological diagnosis of BDB. Read More

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http://dx.doi.org/10.1038/s41379-020-0577-1DOI Listing

From observed laterality to latent hemispheric differences: Revisiting the inference problem.

Laterality 2020 May 26:1-23. Epub 2020 May 26.

Center for Lifespan Changes in Brain and Cognition (LCBC), Department of Psychology, University of Oslo, Oslo, Norway.

Researchers interested in hemispheric dominance frequently aim to infer latent functional differences between the hemispheres from observed lateral behavioural or brain-activation differences. To be valid, these inferences may not only rely on the observed laterality measures but also need to account for the antecedent probabilities of the studied latent classes. This fact is frequently ignored in the literature, leading to misclassifications especially when considering low probability classes as, for example, "atypical" right hemispheric language dominance. Read More

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http://dx.doi.org/10.1080/1357650X.2020.1769124DOI Listing

Melanotic Schwannoma, a Deceptive Misnomer for a Tumor With Relative Aggressive Behavior: A Series of 7 Cranial and Spinal Cases.

Int J Surg Pathol 2020 May 26:1066896920923146. Epub 2020 May 26.

Tata Memorial Hospital and ACTREC, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.

The authors present in this article a series of 7 intracranial/spinal cases of melanotic schwannomas that highlight the aggressive nature of these tumors. The series comprises 2 males and 5 females, age range 19 to 50 years, with spinal/paraspinal location in 4/7 (57%), and intracranial (along the trigeminal nerve) location in 3/7 (43%). There was no association with Carney's complex. Read More

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http://dx.doi.org/10.1177/1066896920923146DOI Listing

The Case of an Adolescent Male With Sickle Cell Disease and Atypical Leg Pain.

Clin Pediatr (Phila) 2020 May 26:9922820920020. Epub 2020 May 26.

Virginia Commonwealth University Health System, Richmond, VA, USA.

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http://dx.doi.org/10.1177/0009922820920020DOI Listing

Benign Hepatic Tumors: From Incidental Imaging Finding to Clinical Management.

Korean J Fam Med 2020 May 27. Epub 2020 May 27.

Gastroenterology and Hepatology Institute, Hillel Yaffe Medical Center, Hadera, Israel.

Benign hepatic tumors (BHTs) are commonly detected as incidental finding mainly due to the frequent utilization of imaging modalities, including ultrasound (US), computed tomography (CT), and magnetic resonance imaging (MRI). Rigorous clinical evaluation, with a particular focus on chronic liver disease (CLD) or risk factors for CLD, medication history, physical examination for signs of CLD, blood tests, and a review of past liver radiology constitute the initial steps in the evaluation of a new liver lesion. Further, contrast-enhanced imaging using US, CT and MRI, can be used depending on the clinical scenario and their availability. Read More

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http://dx.doi.org/10.4082/kjfm.18.0188DOI Listing

The Role of Selected Chemokines and Their Receptors in the Development of Gliomas.

Int J Mol Sci 2020 May 24;21(10). Epub 2020 May 24.

Department of Biochemical Diagnostics, University Hospital in Białystok, 15-269 Białystok, Poland.

Among heterogeneous primary tumors of the central nervous system (CNS), gliomas are the most frequent type, with glioblastoma multiforme (GBM) characterized with the worst prognosis. In their development, certain chemokine/receptor axes play important roles and promote proliferation, survival, metastasis, and neoangiogenesis. However, little is known about the significance of atypical receptors for chemokines (ACKRs) in these tumors. Read More

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http://dx.doi.org/10.3390/ijms21103704DOI Listing

Characterization of Atypical Protein Tyrosine Kinase (PTK) Genes and Their Role in Abiotic Stress Response in Rice.

Plants (Basel) 2020 May 23;9(5). Epub 2020 May 23.

Division of Plant Physiology, ICAR-Indian Agricultural Research Institute, New Delhi-110012, India.

Tyrosine phosphorylation constitutes up to 5% of the total phophoproteome. However, only limited studies are available on protein tyrosine kinases (PTKs) that catalyze protein tyrosine phosphorylation in plants. In this study, domain analysis of the 27 annotated genes in rice genome led to the identification of 18 PTKs with tyrosine kinase domain. Read More

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http://dx.doi.org/10.3390/plants9050664DOI Listing

Identification of a novel homozygous mutation as the second cause of Usher syndrome type 4.

Am J Ophthalmol Case Rep 2020 Sep 8;19:100736. Epub 2020 May 8.

Fundació de Recerca de l'Institut de Microcirurgia Ocular, 08035, Barcelona, Spain.

Purpose: Usher syndrome is a genetic disease characterized by combined sensorineural hearing loss, retinitis pigmentosa, and vestibular areflexia, with 15 known causative genes. Depending on the severity and onset of the symptoms, 3 different subtypes of the pathology have been classically established, although an increasing number of rare cases are being accumulated as atypical forms. The present work aims to discover the genetic cause in a patient with atypical Usher syndrome, by performing whole exome sequencing in several family members. Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235610PMC
September 2020

Two cases of a non-progressive hepatic form of glycogen storage disease type IV with atypical liver pathology.

Mol Genet Metab Rep 2020 Sep 18;24:100601. Epub 2020 May 18.

Center for Medical Genetics, Department of Metabolism, Chiba Children's Hospital, 579-1 Heta-cho, Midori-ku, Chiba 266-0007, Japan.

Glycogen storage disease type IV (GSD IV) is a rare inborn metabolic disorder characterized by the accumulation of amylopectin-like glycogen in the liver or other organs. The hepatic subtype may appear normal at birth but rapidly develops to liver cirrhosis in infancy. Liver pathological findings help diagnose the hepatic form of the disease, supported by analyses of enzyme activity and gene variants. Read More

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http://dx.doi.org/10.1016/j.ymgmr.2020.100601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235638PMC
September 2020

Benign testicular cavernous hemangioma presenting with acute onset: A case report.

Mol Clin Oncol 2020 Jul 23;13(1):19-22. Epub 2020 Apr 23.

Department of Andrology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.

Cavernous hemangioma is a congenital, benign vascular tumor that occurs in the deep dermis and subcutaneous tissue. Testicular cavernous hemangioma is extremely rare, mostly occurring during childhood or adolescence. Testicular cavernous hemangioma is a benign tumor that appears as a slowly growing painless mass. Read More

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http://dx.doi.org/10.3892/mco.2020.2033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241247PMC

Label-Free Identification of Early Stages of Breast Ductal Carcinoma via Multiphoton Microscopy.

Scanning 2020 2;2020:9670514. Epub 2020 Apr 2.

Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal University, Fuzhou 350007, China.

Breast cancer can be cured by early diagnosis. Appropriate and effective clinical treatment benefits from accurate pathological diagnosis. However, due to the lack of effective screening and diagnostic imaging methods, early stages of breast cancer often progress to malignant breast cancer. Read More

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http://dx.doi.org/10.1155/2020/9670514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154972PMC

A Proposal for the Performance, Classification, and Reporting of Lymph Node Fine-Needle Aspiration Cytopathology: The Sydney System.

Acta Cytol 2020 May 26:1-17. Epub 2020 May 26.

Department of Medicine and Surgery, Università degli Studi di Salerno, Fisciano, Salerno, Italy,

Background: The evaluation of lymph nodes (LN) by fine-needle aspiration cytology (FNAC) is routinely used in many institutions but it is not uniformly accepted mainly because of the lack of guidelines and a cytopathological diagnostic classification. A committee of cytopathologists has developed a system of performance, classification, and reporting for LN-FNAC.

Methods: The committee members prepared a document that has circulated among them five times; the final text has been approved by all the participants. Read More

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http://dx.doi.org/10.1159/000506497DOI Listing

Salivary gland-type mammary carcinoma arising in microglandular adenosis: A case report and clinicopathological review of the literature.

Cancer Treat Res Commun 2020 May 12;24:100178. Epub 2020 May 12.

Sunnybrook Odette Cancer Centre, 2075 Bayview Avenue, Toronto, ON, M4N 3M5, Canada. Electronic address:

Introduction: Microglandular adenosis (MGA) is a rare benign proliferative lesion lacking a myoepithelial cell layer; 27% of all reported cases have progressed to invasive carcinoma. Salivary gland-type carcinomas of the breast are also uncommon, representing 2% of all breast cancers. This wide spectrum of neoplasms tends to be triple negative and generally has an excellent prognosis. Read More

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http://dx.doi.org/10.1016/j.ctarc.2020.100178DOI Listing

COVID-19 Presenting with Atypical Sweet's Syndrome.

J Eur Acad Dermatol Venereol 2020 May 26. Epub 2020 May 26.

Koç University, School of Medicine, Department of Dermatology and Venereology, Istanbul, Turkey.

On March 11, 2020, the first case of the novel coronavirus 2019 disease (COVID-19) was officially confirmed in Turkey. The disease continues to spread, and the number of patients has risen to 120,000 by the end of April. In this observation, we report an atypical presentation of COVID-19 in a patient with indurated painful nodules. Read More

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http://dx.doi.org/10.1111/jdv.16662DOI Listing

Placental histopathology in sickle cell disease: A descriptive and hypothesis-generating study.

Placenta 2020 Apr 17;95:9-17. Epub 2020 Apr 17.

Mount Sinai Hospital, Department of Obstetrics and Gynaecology, Division of Maternal-Fetal Medicine, Toronto, Canada; University of Toronto, Department of Medicine, Toronto, Canada; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada.

Introduction: Abnormal placental development is a unifying factor amongst many adverse pregnancy outcomes (APOs) in Sickle Cell Disease (SCD). Our aim was to describe placental histopathologic findings in women with SCD and their relationship with APOs, and to explore the association between antenatal sonographic findings and placental pathology.

Methods: Retrospective single-centre case series of all pregnant women with SCD (January 2000-December 2017), pregnancy beyond 20 weeks' gestation, and available placenta histopathology. Read More

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http://dx.doi.org/10.1016/j.placenta.2020.04.003DOI Listing

Deletion of atypical chemokine receptor 3 (ACKR3) increases immune cells at the fetal-maternal interface.

Placenta 2020 Apr 22;95:18-25. Epub 2020 Apr 22.

Department of Cell Biology and Physiology, 111 Mason Farm Road, 6312B Medical Biomolecular Research Building, CB# 7545, Chapel Hill, NC, 27599, USA; Department of Genetics, 111 Mason Farm Road, 6312B Medical Biomolecular Research Building, CB# 7545, Chapel Hill, NC, 27599, USA; Lineberger Comprehensive Cancer Center, 111 Mason Farm Road, 6312B Medical Biomolecular Research Building, CB# 7545, Chapel Hill, NC, 27599, USA. Electronic address:

Establishment of immune cell populations and adaptations in immune cells are critical aspects during pregnancy that lead to protection of the semi-allogenic fetus. Appropriate immune cell activation and trophoblast migration are regulated in part by chemokines, the availability of which can be fine-tuned by decoy receptors. Atypical chemokine receptor 3 (ACKR3), previously named C-X-C chemokine receptor 7 (CXCR7), is a chemokine decoy receptor expressed in placenta, but little is known about how this receptor affects placental development. Read More

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http://dx.doi.org/10.1016/j.placenta.2020.04.007DOI Listing

ATYPICAL or INTERSTITIAL, take your PIC.

J Physiol 2020 May 26. Epub 2020 May 26.

Department of Physiology, Monash University, Clayton, 3800, Australia.

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http://dx.doi.org/10.1113/JP280080DOI Listing

Class IX Myosins: Motorized RhoGAP Signaling Molecules.

Adv Exp Med Biol 2020 ;1239:381-389

Institute of Molecular Cell Biology, Westfalian Wilhelms University Münster, Münster, Germany.

Class IX myosins are simultaneously motor and signaling molecules. In addition to myosin class-specific functions of the tail region, they feature unique motor properties. Within their motor region they contain a long insertion with a calmodulin- and a F-actin-binding site. Read More

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http://dx.doi.org/10.1007/978-3-030-38062-5_16DOI Listing
January 2020

The Actomyosin Systems in Apicomplexa.

Adv Exp Med Biol 2020 ;1239:331-354

Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

The phylum of Apicomplexa groups obligate intracellular parasites that exhibit unique classes of unconventional myosin motors. These parasites also encode a limited repertoire of actins, actin-like proteins, actin-binding proteins and nucleators of filamentous actin (F-actin) that display atypical properties. In the last decade, significant progress has been made to visualize F-actin and to unravel the functional contribution of actomyosin systems in the biology of Toxoplasma and Plasmodium, the most genetically-tractable members of the phylum. Read More

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http://dx.doi.org/10.1007/978-3-030-38062-5_14DOI Listing
January 2020

Factors associated with drug prescribing practices in long-term care patients with cognitive impairment.

Eur Geriatr Med 2020 May 25. Epub 2020 May 25.

Laboratory for Research on Aging Society, Department of Sociology of Medicine, Chair of Epidemiology and Preventive Medicine, Jagiellonian University Medical College, Kopernika 7a Street, 31-034, Kraków, Poland.

Purpose: To examine factors associated with prescribing anti-dementia medicines (ADM), atypical antipsychotics (A-APM), typical antipsychotics (T-APM), anxiolytics and other psychostimulants (OP) in the residents of long-term care institutions (LTCIs).

Methods: A cross-sectional survey of a country-representative sample of randomly selected LTCIs in Poland, conducted in 2015-2016. First, we identified 1035 residents with cognitive impairment (CI) among all 1587 residents. Read More

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http://dx.doi.org/10.1007/s41999-020-00331-0DOI Listing

Diffuse midline glioma of the cervical spinal cord with H3 K27M genotype phenotypically mimicking anaplastic ganglioglioma: a case report and review of the literature.

Brain Tumor Pathol 2020 May 25. Epub 2020 May 25.

Institute of Pathology, University Hospital Salzburg, Paracelsus Medical University, Müllner Hauptstraße 48, 5020, Salzburg, Austria.

Here, we report on a 28-year old male patient presenting with neck and shoulder pain, dysesthesia of all four limbs and hypesthesia of both hands, without motor deficits. Magnetic resonance imaging showed an intradural, intramedullary mass of the cervical spinal cord of 6.4 cm length and 1. Read More

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http://dx.doi.org/10.1007/s10014-020-00365-zDOI Listing

Gangliosides are essential endosomal receptors for quasi-enveloped and naked hepatitis A virus.

Nat Microbiol 2020 May 25. Epub 2020 May 25.

Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

The Picornaviridae are a diverse family of positive-strand RNA viruses that includes numerous human and veterinary pathogens. Among these, hepatitis A virus (HAV), a common cause of acute hepatitis in humans, is unique in that it is hepatotropic and is released from hepatocytes without lysis in small vesicles that resemble exosomes. These quasi-enveloped virions are infectious and are the only form of virus that can be detected in the blood during acute infection. Read More

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http://dx.doi.org/10.1038/s41564-020-0727-8DOI Listing

ERS/ESTS/EACTS/ESTRO guidelines for the management of malignant pleural mesothelioma.

Eur Respir J 2020 May 25. Epub 2020 May 25.

Dept of Radiation Oncology, Kantonsspital St Gallen, St Gallen, Switzerland.

The European Respiratory Society (ERS)/European Society of Thoracic Surgeons (ESTS)/European Association for Cardio-Thoracic Surgery (EACTS)/European Society for Radiotherapy and Oncology (ESTRO) task force brought together experts to update previous 2009 ERS/ESTS guidelines on management of malignant pleural mesothelioma (MPM), a rare cancer with globally poor outcome, after a systematic review of the 2009-2018 literature. The evidence was appraised using the Grading of Recommendations, Assessment, Development and Evaluation approach. The evidence syntheses were discussed and recommendations formulated by this multidisciplinary group of experts. Read More

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http://dx.doi.org/10.1183/13993003.00953-2019DOI Listing

[The role of new molecular tests in the diagnosis of melanoma in a setting of congenital nævus in an infant].

Ann Dermatol Venereol 2020 May 22. Epub 2020 May 22.

Service de dermatologie, centre de références de maladies rares de la peau et des muqueuses, université Paul-Sabatier, hôpital Larrey, CHU de Toulouse, 24, chemin du Pouvourville, 31400 Toulouse, France.

Introduction: Congenital and infantile melanomas are extremely rare. We report a case of a child presenting at birth with a giant congenital nevus complicated by melanoma and on long-term follow-up with exploration using new immunohistochemistry and molecular biology tools.

Observation: A new-born girl presented at birth with a large congenital cervico-mandibular tumour with para-pharyngeal extension and underlying osteolysis. Read More

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http://dx.doi.org/10.1016/j.annder.2020.03.006DOI Listing

Delayed diagnosis of fatal pneumonic canine plague: clinical and pathologic features in two naturally infected Colorado dogs.

BMC Vet Res 2020 May 25;16(1):160. Epub 2020 May 25.

Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.

Background: Plague caused by Yersinia pestis is a highly infectious and potentially fatal zoonotic disease that can be spread by wild and domestic animals. In endemic areas of the northern hemisphere plague typically cycles from March to October, when flea vectors are active. Clinical forms of disease include bubonic, septicemic, and pneumonic plague. Read More

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http://dx.doi.org/10.1186/s12917-020-02361-zDOI Listing

Intermittent peripheral exposure to lipopolysaccharide induces exploratory behavior in mice and regulates brain glial activity in obese mice.

J Neuroinflammation 2020 May 25;17(1):163. Epub 2020 May 25.

Department of Life Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, Taiwan.

Background: Consecutive peripheral immune challenges can modulate the responses of brain resident microglia to stimuli. High-fat diet (HFD) intake has been reported to stimulate the activation of astrocytes and microglia in the arcuate nucleus (ARC) of the hypothalamus in obese rodents and humans. However, it is unknown whether intermittent exposure to additional peripheral immune challenge can modify HFD-induced hypothalamic glial activation in obese individuals. Read More

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http://dx.doi.org/10.1186/s12974-020-01837-xDOI Listing

A comprehensive description of GluN2B-selective N-methyl-D-aspartate (NMDA) receptor antagonists.

Eur J Med Chem 2020 May 16;200:112447. Epub 2020 May 16.

School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China; Department of Pharmacy, General Hospital of Northern Theater Command, Shenyang, 110840, People's Republic of China. Electronic address:

l-glutamate is an excitatory neurotransmitter in the central nervous system (CNS), which can activate ionotropic receptors (iGluRs) and metabotropic (mGluRs) receptors. N-methyl-D-aspartate (NMDA) receptor is a ligand-gated ion channel belonging to the iGluRs family. Among NMDA receptor subtypes, GluN2B subtype plays a crucial role in CNS diseases. Read More

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http://dx.doi.org/10.1016/j.ejmech.2020.112447DOI Listing

Atypical clinical presentation of Ebola virus disease in pregnancy: Implications for clinical and public health management.

Int J Infect Dis 2020 May 22. Epub 2020 May 22.

Ministry of Health and Sanitation, Youyi Building, Freetown, Sierra Leone.

Background: Between December 2013 and June 2016, West Africa experienced the largest Ebola virus disease (EVD) outbreak in history. Understanding EVD in pregnancy is important for EVD clinical screening and infection prevention and control.

Methods: We conducted a review of medical records and EVD investigation reports from three districts in Sierra Leone. Read More

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http://dx.doi.org/10.1016/j.ijid.2020.05.064DOI Listing

Presenting characteristics, comorbidities, and outcomes of patients coinfected with COVID-19 and Mycoplasma pneumoniae in the USA.

J Med Virol 2020 May 25. Epub 2020 May 25.

Division of Nephrology, Department of Internal Medicine, Adventist Medical Center, Hanford, California.

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is spreading at a rapid pace, and the World Health Organization declared it as pandemic on 11 March 2020. Mycoplasma pneumoniae is an "atypical" bacterial pathogen commonly known to cause respiratory illness in humans. The coinfection from SARS-CoV-2 and mycoplasma pneumonia is rarely reported in the literature to the best of our knowledge. Read More

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http://dx.doi.org/10.1002/jmv.26026DOI Listing

Saccade dysmetria indicates attenuated visual exploration in autism spectrum disorder.

J Child Psychol Psychiatry 2020 May 25. Epub 2020 May 25.

Center for Brain and Cognitive Development, Birkbeck College, University of London, London, UK.

Background: Visual exploration in autism spectrum disorder (ASD) is characterized by attenuated social attention. The underlying oculomotor function during visual exploration is understudied, whereas oculomotor function during restricted viewing suggested saccade dysmetria in ASD by altered pontocerebellar motor modulation.

Methods: Oculomotor function was recorded using remote eye tracking in 142 ASD participants and 142 matched neurotypical controls during free viewing of naturalistic videos with and without human content. Read More

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http://dx.doi.org/10.1111/jcpp.13267DOI Listing

Coronary Artery Disease in patients with End-Stage Kidney Disease; Current perspective and gaps of knowledge.

Semin Dial 2020 May 25. Epub 2020 May 25.

University of Ottawa Heart Institute, Ottawa, ON, Canada.

Coronary artery disease (CAD) is very common in dialysis patients. One third have preexisting CAD and another one third have significant occult disease at the time of starting dialysis. Symptoms are often absent or are atypical, emphasizing the need for vigorous screening, specifically in patients awaiting transplant. Read More

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http://dx.doi.org/10.1111/sdi.12886DOI Listing

Familial dilated cardiomyopathy associated with pathogenic TBX5 variants: Expanding the cardiac phenotype associated with Holt-Oram syndrome.

Am J Med Genet A 2020 May 25. Epub 2020 May 25.

West of Scotland Clinical Genetics Service, Queen Elizabeth University Hospital, Glasgow, UK.

Holt-Oram syndrome (HOS) is a rare, autosomal dominant disorder caused by heterozygous pathogenic variants in cardiac T-box transcription factor, TBX5. Classically, it is associated with upper limb malformations and variable cardiac abnormalities. Limb manifestations are considered to be invariably present, ranging in severity from limitation in movement, to triphalangeal thumbs, absent thumbs, shortened forearms, or phocomelia. Read More

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http://dx.doi.org/10.1002/ajmg.a.61635DOI Listing

Successful recovery from severe COVID-19 pneumonia after kidney transplantation: the interplay between immunosuppression and novel therapy including tocilizumab.

Transpl Infect Dis 2020 May 25:e13334. Epub 2020 May 25.

Department of Transplantation. Division of General Surgery and Transplantation, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.

Although immunosuppressed patients may be more prone to SARS-CoV-2 infection with atypical presentation, long-term immunosuppression therapy may provide some sort of protection for severe clinical complications of COVID-19. The interaction between immunosuppression and new antiviral drugs in the treatment of transplanted patients contracting COVID-19 has not yet been fully investigated. Moreover, data regarding the optimal management of these patients are still very limited. Read More

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http://dx.doi.org/10.1111/tid.13334DOI Listing

ERS/ESTS/EACTS/ESTRO guidelines for the management of malignant pleural mesothelioma.

Eur J Cardiothorac Surg 2020 May 25. Epub 2020 May 25.

Department of Radiation Oncology, Kantonsspital St. Gallen, St. Gallen, Switzerland.

The European Respiratory Society (ERS)/European Society of Thoracic Surgeons (ESTS)/European Association for Cardio-Thoracic Surgery (EACTS)/European Society for Radiotherapy and Oncology (ESTRO) task force brought together experts to update previous 2009 ERS/ESTS guidelines on management of malignant pleural mesothelioma (MPM), a rare cancer with globally poor outcome, after a systematic review of the 2009-2018 literature. The evidence was appraised using the Grading of Recommendations, Assessment, Development and Evaluation approach. The evidence syntheses were discussed and recommendations formulated by this multidisciplinary group of experts. Read More

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http://dx.doi.org/10.1093/ejcts/ezaa158DOI Listing

Pulmonary Function in Patients with Multiple Endocrine Neoplasia 2B (MEN2B).

J Clin Endocrinol Metab 2020 May 25. Epub 2020 May 25.

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Context: Multiple endocrine neoplasia type 2B (MEN2B) is a rare cancer predisposition syndrome resulting from an autosomal-dominant germline mutation of the RET proto-oncogene. No prior studies have investigated pulmonary function in patients with MEN2B.

Objective: This study characterized the pulmonary function of patients with MEN2B. Read More

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http://dx.doi.org/10.1210/clinem/dgaa296DOI Listing

Prompt recognition of infectious pulmonary tuberculosis is critical to achieving elimination goals: a retrospective cohort study.

BMJ Open Respir Res 2020 May;7(1)

Department of Medicine; Division of Pulmonary Medicine, University of Alberta, Edmonton, Alberta, Canada

Introduction: All pulmonary tuberculosis (PTB) cases are presumed to be infectious to some degree. This spectrum of infectiousness is independently described by both the acid-fast bacilli smear and radiographic findings. Smear-positive patients with chest radiographic findings that are typical for adult-type PTB are believed to be most infectious. Read More

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http://dx.doi.org/10.1136/bmjresp-2019-000521DOI Listing

Understanding the Radiologist's Role in Evaluating Multiple Sclerosis: A Review of the Tip of the Iceberg.

Semin Ultrasound CT MR 2020 Jun 29;41(3):275-283. Epub 2020 Feb 29.

University of North Carolina at Chapel Hill, Chapel Hill, NC.

Radiologists add value in the setting of clinically suspected multiple sclerosis (MS) predominantly through knowledge of typical and atypical imaging findings, thus aiding the neurologist in differentiating multiple disease processes with similar clinical presentations which may mimic MS. This paper is meant as a guide to deepen understanding for the radiologist, enabling them to be a helpful member of the care team for MS patients. Read More

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http://dx.doi.org/10.1053/j.sult.2020.02.002DOI Listing

Fifteen new nucleotide substitutions in variants of human papillomavirus 18 in Korea : Korean HPV18 variants and clinical manifestation.

Virol J 2020 May 24;17(1):70. Epub 2020 May 24.

Department of Laboratory Medicine, Seoul National University Metropolitan Government Boramae Medical Center, Seoul, South Korea.

High-risk human papillomavirus (HPV) infection is an essential factor for the development of cervical cancer. HPV18 is the second most common carcinogenic HPV type following HPV16, but the lineages of HPV18 have been less well studied than those of HPV 16. The purpose of this study was to analyze the nucleotide variants in the E6, E7, and L1 genes of HPV18, to assess the prevalence of HPV18 variants in Korea and to explore the relationship between HPV18 genetic variants and the risk for cervical cancer. Read More

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http://dx.doi.org/10.1186/s12985-020-01337-7DOI Listing

Pathology features and the results of treatment of two cases of posterior choroidal leiomyoma.

BMC Ophthalmol 2020 May 24;20(1):198. Epub 2020 May 24.

Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Medical Artificial Intelligence Research and Verification Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Background: Posterior choroidal leiomyoma is an extremely rare tumor, to our knowledge, less than 10 cases reported in the literature. The definite diagnosis can be confirmed by immunohistochemistry, and local resection is preferable to enucleation for the posterior choroidal leiomyoma.

Case Presentation: Two adult Asian women presented with progressive vision loss in their right eyes. Read More

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http://dx.doi.org/10.1186/s12886-020-01445-6DOI Listing