118,247 results match your criteria Atypical Antipsychotics : Milestones in Drug Therapy[Journal]


PM2.5 induces EMT and promotes CSC properties by activating Notch pathway in vivo and vitro.

Ecotoxicol Environ Saf 2019 Apr 16;178:159-167. Epub 2019 Apr 16.

Department of Respiratory and Critical Care Medicine, Peking University First Hospital, Beijing, China. Electronic address:

Fine particulate matter (PM2.5) has been closely linked to increased morbidity and mortality of lung cancer worldwide. However, the role of PM2. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.03.086DOI Listing

Cutaneous nontuberculous mycobacteria infections: A retrospective case series of 78 patients from the Texas Gulf Coast region.

J Am Acad Dermatol 2019 Apr 16. Epub 2019 Apr 16.

Department of Dermatology, University of Texas Medical Branch, Galveston, TX.

Background: The incidence of cutaneous nontuberculous mycobacteria (NTM) infections is increasing. These infections are a diagnostic and therapeutic challenge.

Objective: We aimed to investigate clinical features, diagnosis and management of cutaneous NTM infections. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.04.022DOI Listing

Regulation of the apical extension morphogenesis tunes the mechanosensory response of microvilliated neurons.

PLoS Biol 2019 Apr 19;17(4):e3000235. Epub 2019 Apr 19.

Institut du Cerveau et de la Moelle épinière (ICM), Inserm U 1127, CNRS UMR 7225, Sorbonne Université, Paris, France.

Multiple types of microvilliated sensory cells exhibit an apical extension thought to be instrumental in the detection of sensory cues. The investigation of the mechanisms underlying morphogenesis of sensory apparatus is critical to understand the biology of sensation. Most of what we currently know comes from the study of the hair bundle of the inner ear sensory cells, but morphogenesis and function of other sensory microvilliated apical extensions remain poorly understood. Read More

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http://dx.doi.org/10.1371/journal.pbio.3000235DOI Listing

Asymmetrical, Symmetrical, Divalent, and Y-Shaped (Bola)amphiphiles: The Relationship between the Molecular Structure and Self-Assembly in Amino Derivatives of Sophorolipid Biosurfactants.

J Phys Chem B 2019 Apr 19. Epub 2019 Apr 19.

Laboratory for Chemical Technology (LCT), Department of Materials, Textiles and Chemical Engineering , Ghent University , Technologiepark 125 , 9052 Ghent , Belgium.

Conventional head-chain but also more exotic divalent, Gemini, or bolaform amphiphiles have in common well-defined hydrophilic and hydrophobic blocks with often a predictable self-assembly behavior. However, new categories of amphiphiles, such as microbial biosurfactants, challenge such conventional understanding because of the poorly defined boundaries between the hydrophilic and hydrophobic portions. Microbial glycolipids, such as sophorolipids, rhamnolipids, or cellobioselipids, interesting biodegradable, nontoxic, alternatives to synthetic surfactants, all represent interesting examples of atypical amphiphiles with partially predictable self-assembly properties. Read More

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http://dx.doi.org/10.1021/acs.jpcb.9b01013DOI Listing

Follow-up outcomes of benign vascular lesions of breast diagnosed on core needle biopsy: A study of 117 cases.

Breast J 2019 Apr 18. Epub 2019 Apr 18.

Department of Pathology, Magee-Womens Hospital of University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

Benign vascular lesions of breast are uncommon findings on core biopsy and surgical excision has been recommended to rule out a more serious lesion. However, a recent study suggested that excision may be spared for vascular lesion without atypia. The aim of this study was to assess the follow-up outcomes in lesions yielding benign vascular lesions on core biopsy. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/tbj.13233
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http://dx.doi.org/10.1111/tbj.13233DOI Listing
April 2019
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Trends in frequency and outcome of high-risk breast lesions at core needle biopsy in women recalled at biennial screening mammography, a multi-institutional study.

Int J Cancer 2019 Apr 19. Epub 2019 Apr 19.

Department of Radiology, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands.

Between January 1, 2011 and December 31, 2016 we studied the incidence, management and outcome of high-risk breast lesions in a consecutive series of 376,519 screens of women who received biennial screening mammography. During the 6-year period covered by the study, the proportion of women who underwent core needle biopsy (CNB) following recall remained fairly stable, ranging from 39.2% to 48. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32353
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http://dx.doi.org/10.1002/ijc.32353DOI Listing
April 2019
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Pediatric meningiomas: a report of 5 cases and review of literature.

Childs Nerv Syst 2019 Apr 18. Epub 2019 Apr 18.

Division of Neurosurgery, National Center for Child Health and Development, Tokyo, Japan.

Purpose: The purpose of this paper is to provide novel insight into the rare pediatric meningiomas.

Methods: We retrospectively analyzed pediatric surgical cases of meningioma during 2002 to 2017 in our institution. The preoperative, intraoperative, and the postoperative status were collected to find any unique features that has not reported in the past. Read More

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http://link.springer.com/10.1007/s00381-019-04142-y
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http://dx.doi.org/10.1007/s00381-019-04142-yDOI Listing
April 2019
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Olanzapine: A potent agonist at the hM4D(Gi) DREADD amenable to clinical translation of chemogenetics.

Sci Adv 2019 Apr 17;5(4):eaaw1567. Epub 2019 Apr 17.

Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, UK.

Designer receptors exclusively activated by designer drugs (DREADDs) derived from muscarinic receptors not only are a powerful tool to test causality in basic neuroscience but also are potentially amenable to clinical translation. A major obstacle, however, is that the widely used agonist clozapine -oxide undergoes conversion to clozapine, which penetrates the blood-brain barrier but has an unfavorable side effect profile. Perlapine has been reported to activate DREADDs at nanomolar concentrations but is not approved for use in humans by the Food and Drug Administration or the European Medicines Agency, limiting its translational potential. Read More

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http://dx.doi.org/10.1126/sciadv.aaw1567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469940PMC

Verbal Fluency Is Affected by Altered Brain Lateralization in Adults Who Were Born Very Preterm.

eNeuro 2019 Mar-Apr;6(2). Epub 2019 Apr 15.

Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom SE5 8AF.

Language difficulties have been reported in children and adolescents who were born very preterm (<32 weeks' gestation) and associated with an atypical lateralization of language processing, i.e., increased right-hemispheric engagement. Read More

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http://dx.doi.org/10.1523/ENEURO.0274-18.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469882PMC

Performance of Different Combination Models of High-Risk HPV Genotyping in Triaging Chinese Women With Atypical Squamous Cells of Undetermined Significance.

Front Oncol 2019 3;9:202. Epub 2019 Apr 3.

Department of Cancer Epidemiology, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China.

The purpose of this study was to evaluate the effect of different combination models of high-risk human papilloma viruses (HPV) genotyping in triaging Chinese women with atypical squamous cells of undetermined significance (ASCUS). We established a screening cohort of 3,997 Chinese women who underwent cervical cytology and HPV genotyping test. Women with ASCUS cytology underwent punch biopsy under colposcopy/endocervical curettage. Read More

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http://dx.doi.org/10.3389/fonc.2019.00202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456653PMC

Impact of Etiology on Efficacy of Oral Triclofos in Recording Pediatric Electroencephalography: A Tertiary Care Center Study.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):234-237

Department of Neurology, Niloufer Children's Hospital, Hyderabad, Telangana, India.

Background And Objectives: Oral triclofos is a frequently used sedative in pediatric age to record sleep Electroencephalography (EEG). This study is aimed to assess efficacy, safety profile, need for second dose, and rescheduling of oral triclofos in relation to etiology.

Materials And Methods: This is a retrospective study done enrolling all children aged 6 months to 5 years referred for EEG over 1 year. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_280_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454965PMC

Protective cardiac conditioning by an atypical cytokine.

Clin Sci (Lond) 2019 Apr 18;133(8):933-937. Epub 2019 Apr 18.

Chair of Vascular Biology, Institute for Stroke and Dementia Research (ISD), Klinikum der Universität München (KUM), Ludwig-Maximilians-University (LMU), Munich 81377, Germany

Ischemic heart disease (IHD) represents the leading cause of morbidity and mortality worldwide. Therapy options generally aim at restoring the blood flow to the heart muscle and relieve the ischemic insult. Paradoxically, coronary artery reperfusion itself, both during emergency intervention in ST segment elevation myocardial infarction (STEMI) patients or in the setting of elective cardiac surgery, damages the heart muscle, a phenomenon known as myocardial ischemia-reperfusion (I/R) injury (IRI). Read More

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http://www.clinsci.org/lookup/doi/10.1042/CS20190036
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http://dx.doi.org/10.1042/CS20190036DOI Listing
April 2019
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Central neurocytoma: SNP array analyses, subtel FISH, and review of the literature.

Pathol Res Pract 2019 Mar 27. Epub 2019 Mar 27.

Saxonian Incubator for Clinical Translation, University of Leipzig, Philipp-Rosenthal Str. 55, 04103 Leipzig, Germany. Electronic address:

The central neurocytoma (CN) is a rare brain tumor with a frequency of 0.1-0.5% of all brain tumors. Read More

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http://dx.doi.org/10.1016/j.prp.2019.03.025DOI Listing

Soft-tissue fat tumours: differentiating malignant from benign using proton density fat fraction quantification MRI.

Clin Radiol 2019 Apr 15. Epub 2019 Apr 15.

Department of Molecular Medicine and Surgery, Karolinska Institutet, Solnavägen 1, 171 77, Stockholm, Sweden; Department of Orthopaedic Surgery, Karolinska University Hospital, Solna, Stockholm, Sweden.

Aim: To evaluate if quantifying proton density fat fraction (PDFF) would be useful in separating lipoma, atypical lipomatous tumour (ALT) and liposarcoma in the extremities and trunk. In addition, differentiating ALT versus non-classical lipomas using magnetic resonance imaging (MRI)-based fatty acid composition (FAC) and three-dimensional (3D) texture analysis was tested.

Material And Methods: This prospective study (undertaken between 2014-2017; comprising 20 women, 21 men) was approved by the Regional Ethical Review Board and informed consent was obtained from all participants. Read More

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http://dx.doi.org/10.1016/j.crad.2019.01.011DOI Listing

Surgical outcome in patients with biliary colic and atypical workup findings.

Am J Surg 2019 May 27;217(5):986-989. Epub 2019 Mar 27.

Meridian Surgery Center, Puyallup, WA, USA.

Background: Surgical response of patients with symptomatic biliary colic but atypical findings of gallbladder polyps, hyper-dynamic gallbladder and otherwise negative biliary workup are underrepresented in the literature from community practice.

Methods: A clinical outcome study with a retrospective design compared the short term and long term symptomatic improvement reported by patients with pre-operatively diagnosed biliary dyskinesia to all other biliary colic patients with atypical pre-operative diagnoses. All patients underwent surgery at Meridian Surgery Center from the years 2010-2017. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2019.03.017DOI Listing

Meningioma and psychiatric symptoms: An individual patient data analysis.

Asian J Psychiatr 2019 Mar 28;42:94-103. Epub 2019 Mar 28.

Department of Psychiatry, Dr Ram Manohar Lohia Hospital PGIMER, New Delhi, India.

Meningioma is a slow-growing benign tumor arising from meninges and is usually asymptomatic. Though neuropsychiatric symptoms are common in patients with brain tumors, they often can be the only manifestation in cases of meningioma. Meningiomas might present with mood symptoms, psychosis, memory disturbances, personality changes, anxiety, or anorexia nervosa. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18762018183113
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http://dx.doi.org/10.1016/j.ajp.2019.03.029DOI Listing
March 2019
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Unusual clinical description of adult with Timothy syndrome, carrier of a new heterozygote mutation of CACNA1C.

Eur J Med Genet 2019 Apr 15. Epub 2019 Apr 15.

Service Génétique, Génétique Clinique, CHU, Caen, France; Normandy University, UNICAEN, BIOTARGEN, Caen, France.

CANAC1C encodes for the main cardiac L-type calcium channel and mutations on it lead to a prolonged QT interval in Timothy Syndrome (TS). We provide a new de novo constitutional heterozygote missense variation in CACNA1C in a living adult woman, also carrier of the known c.2146-1G>C heterozygous variation of PKP2 inherited from her father. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17697212183083
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http://dx.doi.org/10.1016/j.ejmg.2019.04.005DOI Listing
April 2019
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"A Disappearing Lung Mass: Round Pneumonia".

Am J Med 2019 Apr 15. Epub 2019 Apr 15.

Department of Medicine, St. Vincent's Medical Center, Bridgeport, CT, The Frank H. Netter MD School of Medicine at Quinnipiac University, North, Haven, CT, United States. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2019.03.030DOI Listing

Antipsychotics in the general population and the driver population: comparisons from a population-based registry study.

Int Clin Psychopharmacol 2019 Apr 15. Epub 2019 Apr 15.

Pharmacology and Therapeutics, Faculty of Medicine, University of Valladolid, Valladolid.

Antipsychotics are considered driving-impairing medicines. A population-based registry study design was conceived to assess the year-2016 antipsychotic dispensation in Castile and León, Spain. Weighting was performed to obtain the adjusted antipsychotic consumption for licensed drivers according to age and gender using the Spanish national drivers' license census data. Read More

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http://dx.doi.org/10.1097/YIC.0000000000000263DOI Listing

Exploiting Typicality for Selecting Informative and Anomalous Samples in Videos.

IEEE Trans Image Process 2019 Apr 17. Epub 2019 Apr 17.

In this paper, we present a novel approach to find informative and anomalous samples in videos exploiting the concept of typicality from information theory. In most video analysis tasks, selection of the most informative samples from a huge pool of training data in order to learn a good recognition model is an important problem. Furthermore, it is also useful to reduce the annotation cost as it is time-consuming to annotate unlabeled samples. Read More

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https://ieeexplore.ieee.org/document/8693693/
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http://dx.doi.org/10.1109/TIP.2019.2910634DOI Listing
April 2019
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Cosolvent-enhanced Sampling and Unbiased Identification of Cryptic Pockets Suitable for Structure-based Drug Design.

J Chem Theory Comput 2019 Apr 18. Epub 2019 Apr 18.

Modulating protein activity with small molecules binding to cryptic pockets offers great opportunities to overcome hurdles in drug design. Cryptic sites are atypical binding sites in proteins that are closed in the absence of a stabilizing ligand and are thus inherently difficult to identify. Many studies have proposed methods to predict cryptic sites. Read More

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http://dx.doi.org/10.1021/acs.jctc.8b01295DOI Listing

[Clinical role of Morphology in Diagnosing Bone Marrow Involvement of Diffuse Large B Bell Lymphoma].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):421-425

Department of Hematology, Peking Union Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China,E-mail:

Objective: To determine the significance of morphology of bone marrow smear for diagnosis of bone marrow involvement in patients with diffuse large B-cell lymphoma (DLBCL), and to study the morphological characteristics of DLBCL cells involved in bone marrow.

Methods: Four hundred and twenty cases of DLBCL diagnosed at Peking Union Hospital from 2006 to 2016 were analyzed and identified.

Results: Blinded analysis of bone marrow smear and bone marrow biopsy data showed involvement in 42 cases on smears (S), in 47cases by biopsy (B) and the in 49 cases by (S+B). Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2019.02.018DOI Listing

Is there any difference between endometrial hyperplasia and endometrial carcinoma in terms of expression of TRPM2 and TRPM7 ion channels?

Turk J Med Sci 2019 Apr 18;49(2):653-660. Epub 2019 Apr 18.

Background/aim: This study compared TRPM2 and TRPM7 ion channel gene expression and immunohistochemical staining in endometrial hyperplasia and endometrium adenocarcinoma.

Materials And Methods: Sections were taken from paraffin blocks of 120 patients who were divided into 6 groups as follows: G1 (n = 20), proliferative endometrium (PE); G2 (n = 20), EH without atypia; G3 (n = 20), EH with atypia; G4 (n = 20), stage 1A, grade 1 EC; G5 (n = 20), stage 1A, grade 2 EC; and G6 (n = 20), stage 1A, grade 3 EC. TRPM2 and TRPM7 genes were analyzed with qRT-PCR in paraffin-embedded tissue samples. Read More

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http://dx.doi.org/10.3906/sag-1810-176DOI Listing
April 2019
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Enteric nervous system in the European beaver (Castor fiber) pylorus - an immunohistochemical study.

Pol J Vet Sci 2019 Mar;22(1):101-107

Department of Animal Anatomy, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 13, 10-718 Olsztyn, Poland.

European beaver (Castor fiber), the largest rodent species inhabiting a wide area of Eurasia, feeds mainly on dry parts of plants, bark or wood. Such kind of nourishment needs to be properly digested in each part of the gastrointestinal tract. The time of stomach digestion, which directly influences all the following steps of the digestion process, is precisely controlled by the pylorus and its innervation. Read More

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http://journals.pan.pl/dlibra/publication/127076
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http://dx.doi.org/10.24425/pjvs.2019.127076DOI Listing
March 2019
2 Reads

Key dermoscopic signs in the diagnosis and progression of extrafacial lentigo maligna: Evaluation of a series of 41 cases.

Australas J Dermatol 2019 Apr 17. Epub 2019 Apr 17.

Dermatology Service, Hospital Fundación de Alcorcón, Madrid, Spain.

Background/objectives: Lentigo maligna is usually located on the face. Extrafacial lentigo maligna is less common, and diagnosis of early forms is very difficult. Confocal microscopy of facial and extrafacial lentigo maligna shares the same features (abundant dendritic cells and generalised atypical junctional thickenings) and helps us to identify the dermoscopic features of extrafacial lentigo maligna. Read More

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http://dx.doi.org/10.1111/ajd.13051DOI Listing

[Specific cases of slipped capital femoral epiphysis : Endocrinopathies, hormone therapy and other rare causes].

Orthopade 2019 Apr 17. Epub 2019 Apr 17.

Orthopädische Klinik, Olgahospital, Klinikum Stuttgart, Kriegsbergstr. 62, 70174, Stuttgart, Deutschland.

In slipped capital femoral epiphysis (SCFE) atypical causes can be found in about 5% of cases. The patients' age differs from the typical age of SCFE patients of between age 10 and 16. There are numerous causes of atypical SCFE: different endocrine disorders, sequelae of chronic renal failure and effects of radiation and chemotherapy on the proximal femoral physis. Read More

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http://dx.doi.org/10.1007/s00132-019-03728-3DOI Listing

Atypical blastomycosis in a pregnant woman.

Int J Womens Dermatol 2019 Jun 29;5(2):131-133. Epub 2018 Dec 29.

University of Vermont College of Medicine.

Blastomycosis is a rare fungal infection that frequently involves the skin. Atypical presentations are important to identify, especially in pregnant patients, to initiate appropriate therapy and prevent complications. Uniquely, we describe a case of atypical blastomycosis that presented with painful cutaneous abscesses in a pregnant patient, with dissemination to the central nervous system. Read More

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http://dx.doi.org/10.1016/j.ijwd.2018.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451747PMC

An array of unusual clinical features in a woman with amlodipine-induced linear immunoglobulin A disease.

Int J Womens Dermatol 2019 Jun 24;5(2):92-95. Epub 2019 Jan 24.

Department of Dermatology, Maulana Azad Medical College, New Delhi, India.

Linear immunoglobulin A disease (LAD) is a rare, autoimmune, vesicular-bullous disease that is either idiopathic or drug-induced, most commonly by vancomycin and in rare instances by amlodipine. In drug-induced LAD, certain uncommon and atypical clinical features can occur. In our patient, a 49-year-old woman with amlodipine-induced LAD, atypical features such as koebnerization and palmo-plantar involvement occurred. Read More

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http://dx.doi.org/10.1016/j.ijwd.2018.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451764PMC

Clinical Conundrums in the Management of Diabetic Ketoacidosis in the Elderly.

J Transl Int Med 2019 Mar 29;7(1):10-14. Epub 2019 Mar 29.

St. Vincent Hospital Indianapolis, IN, Indianapolis, USA.

One of the dreaded life-threatening complications of diabetes mellitus (DM) is diabetic ketoacidosis (DKA). American Diabetic Association (ADA) came out with 2018 guidelines on the management of DM and its complications, but these are woefully silent on the clinical conundrums that accompany DKA in elderly patients. In elderly patients, DKA is often complicated by sepsis, atrial fibrillation, polypharmacy, nonketotic hyperosmolar states, atypical clinical presentations, acute kidney injury (AKI), dementia, and noncompliance with medications. Read More

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http://content.sciendo.com/view/journals/jtim/7/1/article-p1
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http://dx.doi.org/10.2478/jtim-2019-0003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463825PMC
March 2019
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Catheter ablation of atypical flutter using new 3-dimensional electroanatomic mapping software focusing on areas of conduction block.

HeartRhythm Case Rep 2019 Apr 14;5(4):225-228. Epub 2019 Jan 14.

Department of Cardiology, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.hrcr.2019.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453451PMC

Peritonitis from : An emerging pathogen.

Clin Case Rep 2019 Apr 18;7(4):829-831. Epub 2019 Mar 18.

Department of Family Medicine Kaweah Delta Medical Center Visalia California.

can be misidentified as , due to similar biochemical properties. Automated identification systems and mass spectrometry play a very critical role in isolating atypical organisms like . General guidelines recommend treating peritonitis for 3 weeks without removal of peritoneal dialysis catheter. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ccr3.2094
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http://dx.doi.org/10.1002/ccr3.2094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452466PMC
April 2019
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An adult case of atypical familial Mediterranean fever (pyrin-associated autoinflammatory disease) similar to adult-onset Still's disease.

Clin Case Rep 2019 Apr 12;7(4):801-805. Epub 2019 Mar 12.

Division of Clinical Nephrology and Rheumatology Niigata University Graduate School of Medical and Dental Sciences Niigata Japan.

We present a 55-year-old woman with periodic fever and symptoms similar to adult-onset Still's disease (AOSD). She had a heterogeneous mutation of the gene and colchicine was effective. Atypical familial Mediterranean fever (pyrin-associated autoinflammatory disease) should be considered in patients with periodic fever accompanied by symptoms similar to AOSD. Read More

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http://dx.doi.org/10.1002/ccr3.2102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452483PMC

Does transbronchial lung cryobiopsy give useful information in asthmatic patients?

Multidiscip Respir Med 2019 8;14:12. Epub 2019 Apr 8.

Department of Thoracic Diseases, "GB. Morgagni" Hospital, Forlì, Italy.

Introduction: Lung biopsy in asthmatic patients is justified in case of atypical presentations of asthma, when other differential diagnoses, such as hypersensitivity pneumonitis or eosinophilic granulomatosis with polyangiitis, could be possible or for research purposes.

Aim: We aim to describe the utility and the safety of TBLC (transbronchial lung cryobiopsy) in asthmatic patients, providing data on the pathological changes occurring in the airways and in the lung parenchyma.

Methods: We reviewed asthmatic patients that underwent TBLC, that eventually had only a final diagnosis of asthma. Read More

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http://dx.doi.org/10.1186/s40248-019-0176-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452509PMC

A novel homozygous variation in the gene in two Persian siblings with atypical pantothenate kinase associated neurodegeneration.

Neurol Int 2019 Mar 11;11(1):7959. Epub 2019 Mar 11.

Iran University of Medical Sciences, Tehran.

Pantothenate Kinase-associated Neurodegeneration (PKAN) is an autosomal recessive disorder that is caused by variation in pantothenate kinase-2 gene () gene on chromosome 20. The common presentation of this disease includes progressive dystonia, Parkinsonism, retinopathy, cognitive impairment, and spasticity. The typical magnetic resonance imaging finding is sign in globus pallidus and not pathogenic and not found in all patients. Read More

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https://www.pagepress.org/journals/index.php/ni/article/view
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http://dx.doi.org/10.4081/ni.2019.7959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444562PMC
March 2019
1 Read

Evidence for clinicians: Atypical antipsychotics for disruptive behaviour disorders in children and youths.

Authors:
Iliana Ortega

Paediatr Child Health 2019 May 9;24(2):125-127. Epub 2018 Dec 9.

Clinical Fellow, Psychopharmacology Research Unit, University of Calgary, Mathison Centre for Mental Health Research & Education, Calgary, Canada.

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http://dx.doi.org/10.1093/pch/pxy156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462132PMC

A Long-term Survival after Surgical Treatment for Atypical Aortic Coarctation Complicating Takayasu Arteritis with Inactive Disease at the Diagnosis: An Appropriately Treated Autopsy Case.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Division of Rheumatology, Department of Internal Medicine, Kanazawa University Graduate School of Medicine, Japan.

The number of Takayasu arteritis (TAK) cases being diagnosed at an advanced age has increased, including some who develop ischemic lesions without inflammation of the involved arteries long after the onset of TAK. However, few histopathological analyses of such patients without immunosuppressive therapy have been reported. We herein report a 92-year-old woman with atypical aortic coarctation complicating TAK who underwent bypass graft surgery and survived for 23 years without immunosuppressive therapy. Read More

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http://dx.doi.org/10.2169/internalmedicine.2483-18DOI Listing
April 2019
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Oligosecretory Primary Plasma Cell Leukemia with Atypical Morphological Abnormality.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Hematology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Japan.

Plasma cell leukemia (PCL) is a rare variant of multiple myeloma. The detection of plasma cells in the peripheral blood and monoclonal protein in the serum or urine is important for the diagnosis of PCL. However, it is sometimes difficult to diagnose PCL in patients with atypical plasma cell morphology and/or those without detectable monoclonal protein. Read More

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http://dx.doi.org/10.2169/internalmedicine.2472-18DOI Listing

Atypical Endoscopic Findings of Rectal Perineurioma.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Division of Gastroenterology, NTT Medical Center, Japan.

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https://www.jstage.jst.go.jp/article/internalmedicine/advpub
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http://dx.doi.org/10.2169/internalmedicine.2316-18DOI Listing
April 2019
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Usefulness of [C] Methionine PET in the Differentiation of Tumefactive Multiple Sclerosis from High Grade Astrocytoma.

Neurol Med Chir (Tokyo) 2019 Apr 17. Epub 2019 Apr 17.

Department of Neurosurgery, Tokyo Medical and Dental University.

Tumefactive multiple sclerosis (tumefactive MS) is an atypical variant of MS characterized by a large isolated demyelinating lesion. Because tumefactive MS mimics high grade astrocytoma clinically and radiologically, it is difficult to distinguish between the two using only traditional diagnostic modalities, such as routine magnetic resonance imaging. [C] methionine positron emission tomography (MET PET) has been known as a useful diagnostic tool for glioma. Read More

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http://dx.doi.org/10.2176/nmc.oa.2018-0287DOI Listing

IgG4 Sclerosing Cholangitis - an Inflammation Imitating Tumour of the Pancreas and Biliary Tract.

Klin Onkol 2019 ;32(2):143-151

Background: Immunoglobulin (Ig) G4 associated sclerosing cholangitis is a rare inflammatory disease of the biliary tract. Although it is a very progressive condition, it responds to steroid therapy. IgG4 associated sclerosing cholangitis can mimic pancreatic carcinoma, cholangiocarcinoma, and primary sclerosing cholangitis; therefore, it is very important to obtain a differential diagnosis. Read More

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https://www.linkos.cz/english-summary/klinicka-onkologie-jou
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http://dx.doi.org/10.14735/amko2019143DOI Listing
January 2019
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Rapid, Heuristic Discovery and Design of Promoter Collections in Non-Model Microbes for Industrial Applications.

ACS Synth Biol 2019 Apr 17. Epub 2019 Apr 17.

Well-characterised promoter collections for synthetic biology applications are not always available in industrially relevant hosts. We developed a broadly applicable method for promoter identification in atypical microbial hosts that requires no a priori understanding of cis-regulatory element structure. This novel approach combines bioinformatic filtering with rapid empirical characterisation to expand the promoter toolkit, and uses machine learning to improve the understanding of the relationship between DNA sequence and function. Read More

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http://dx.doi.org/10.1021/acssynbio.9b00061DOI Listing

Inhibition of Growth and Aflatoxin Production of Aspergilli in Medium Containing Phosphates.

J Food Prot 1989 Jan;52(1):4-6

Departments of Food Technology and Animal Science, and Veterinary Diagnostic Laboratory, Iowa State University, Ames, Iowa 50011.

Mycelial growth and mycotoxin production of Aspergillus flavus and A. parasiticus were studied in Sabouraud dextrose agar containing pure or blended pyro-, poly- or meta-phosphates during 9 d of incubation at 30°C. Pure tetrasodium pyrophosphate (TSPP) and sodium polyphosphate, glassy (SPG, formerly hexametaphosphate), as well as a commercial phosphate blend and three combinations all containing various proportions of sodium acid pyrophosphate (SAPP), TSPP and SPG were tested. Read More

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http://jfoodprotection.org/doi/abs/10.4315/0362-028X-52.1.4
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http://dx.doi.org/10.4315/0362-028X-52.1.4DOI Listing
January 1989
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Preoperative and histological predictors of recurrence and survival in atypical meningioma after initial gross total resection.

World Neurosurg 2019 Apr 14. Epub 2019 Apr 14.

Department of Neurosurgery; Department of Otolaryngology, Icahn School of Medicine at Mount Sinai, New York, NY, USA 10029. Electronic address:

Objective: Atypical (WHO grade II) meningiomas (AM) are associated with a substantial risk for recurrence even following a complete, gross total resection (GTR). The present study aimed to evaluate clinical and AM tumor histopathological features that may predict risk of recurrence and survival within this patient population.

Methods: 72 consecutive patients and corresponding tumor specimens who received a primary GTR for an AM from 2007-2016 at a single institution were reviewed. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.069DOI Listing

RalA and RalB relocalization to depolarized mitochondria depends on clathrin-mediated endocytosis and facilitates TBK1 activation.

PLoS One 2019 17;14(4):e0214764. Epub 2019 Apr 17.

Department of Microbiology, Immunology and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America.

Healthy mitochondria use an electrochemical gradient across the inner mitochondrial membrane (IMM) to generate energy in the form of ATP. A variety of endogenous and exogenous factors can lead to transient or sustained depolarization of the IMM, including mitochondrial fission events, expression of uncoupling proteins, electron transport chain (ETC) inhibitors, or chemical uncouplers. This depolarization in turn leads to a variety of physiological responses, ranging from selective mitochondrial clearance (mitophagy) to cell death. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214764PLOS

Detection and Characterization of Atypical Renal Cysts and Solid Renal Masses in Kidney Transplant Patients by Use of Dual-Energy CT Iodine Maps.

AJR Am J Roentgenol 2019 Apr 17:1-8. Epub 2019 Apr 17.

1 Department of Radiology, Amiens University Hospital, Ave Rene Laennec, Amiens, France 80054.

The purpose of this study was to evaluate whether dual-energy CT follow-up of kidney transplant recipients performed with only two contrast-enhanced phases and reconstructed material maps has the same diagnostic efficiency as triphasic conventional CT in detection and characterization of atypical renal cysts and renal masses. In a retrospective study, 175 renal transplant patients underwent dual-energy CT as part of their follow-up (monoenergetic unenhanced, late contrast-enhanced, and tubular contrast-enhanced dual-energy phases). An unenhanced virtual series and material separation maps were reconstructed. Read More

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http://dx.doi.org/10.2214/AJR.18.20574DOI Listing

Design, synthesis and pre-clinical characterization of selective Factor D inhibitors targeting the alternative complement pathway.

J Med Chem 2019 Apr 17. Epub 2019 Apr 17.

Complement Factor D (FD), a highly specific S1 serine protease, plays a central role in the amplification of the alternative complement pathway (AP) of the innate immune system. Dysregulation of AP activity predisposes individuals to diverse disorders such as age-related macular degeneration (AMD), atypical hemolytic uremic syndrome (aHUS), membranoproliferative glomerulonephritis type II (MPGNII) and paroxysmal nocturnal hemoglobinuria (PNH). Previously, we have reported the screening efforts and identification of reversible benzylamine-based FD inhibitors (1 and 2) binding to the open active conformation of FD. Read More

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http://dx.doi.org/10.1021/acs.jmedchem.9b00271DOI Listing

Eosinophilic fasciitis: an atypical presentation of a rare disease.

Rev Assoc Med Bras (1992) 2019 Mar 11;65(3):326-329. Epub 2019 Apr 11.

Internal Medicine Service, Hospital de Braga, Braga, Portugal.

Eosinophilic fasciitis, or Shulman's disease, is a rare disease of unknown etiology. It is characterized by peripheral eosinophilia, hypergammaglobulinemia, and high erythrocyte sedimentation rate. The diagnosis is confirmed by a deep biopsy of the skin. Read More

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http://dx.doi.org/10.1590/1806-9282.65.3.326DOI Listing

Clinical and laboratory profiles of children with severe chikungunya infection.

Rev Soc Bras Med Trop 2019 Apr 11;52:e20180232. Epub 2019 Apr 11.

Departamento de Saúde Comunitária, Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, CE, Brasil.

Introduction: Chikungunya infection presents with distinct clinical features depending on the patient age group.

Methods: Medical records of children with positive IgM for the chikungunya virus who were hospitalized in a pediatric ward in Fortaleza, Ceará, Brazil were analyzed.

Results: Fourteen children with a median age of 4 months (36 days to 15 years) were included. Read More

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http://dx.doi.org/10.1590/0037-8682-0232-2018DOI Listing
April 2019
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