J Am Acad Dermatol 2017 Nov 25;77(5):930-937. Epub 2017 Apr 25.
Biophotonics Group, Department of Quantum Electronics, Institute of Physics Gleb Wataghin, University of Campinas, Campinas, Brazil; National Institute of Science and Technology on Photonics Applied to Cell Biology, University of Campinas, Campinas, Brazil; Department of Physics, Federal University of Ceara, Fortaleza, Brazil.
Background: The diagnosis of idiopathic atrophoderma of Pasini and Pierini (IAPP) relies on typical clinical features, particularly distinctive pigmented ovular/round depressed plaques. Histologic examination often reveals no obvious changes, but patterns of collagen distribution, using multiphoton imaging and second harmonic generation can help track hidden details of tissue organization contributing to atrophy.
Objective: To identify histologic features that distinguish IAPP from unaffected skin. Read More