52,323 results match your criteria Atrioventricular Dissociation


Brugada electrocardiogram pattern and right bundle branch block: Authors' reply.

Europace 2019 Mar 16. Epub 2019 Mar 16.

Department of Cardiology, Angiology and Intensive Care Medicine, University Heart Center Lübeck, Medical Clinic II, University of Lübeck, Ratzeburger Allee 160, Lübeck, Germany.

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http://dx.doi.org/10.1093/europace/euz049DOI Listing

Brugada electrocardiogram pattern and right bundle branch block.

Europace 2019 Mar 16. Epub 2019 Mar 16.

Department of Medicine, Division of Cardiology, Heart Rhythm Service, Queen's University, Kingston General Hospital, Kingston, Ontario, Canada.

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http://dx.doi.org/10.1093/europace/euz020DOI Listing

Glycerol derived process contaminants in refined coconut oil induce cholesterol synthesis in HepG2 cells.

Food Chem Toxicol 2019 Mar 13. Epub 2019 Mar 13.

Division of Nutritional Sciences, Cornell University, Ithaca, NY, 14853, USA; Dell Pediatric Research Institute and the Depts. of Chemistry, of Pediatrics, and of Nutrition, University of Texas at Austin, 1400 Barbara Jordan Blvd, Austin, TX, 78723, USA. Electronic address:

Despite its 50-year history, the conventional diet-heart hypothesis holding that dietary saturated fats raise serum cholesterol, and with it, cardiovascular risk, remains controversial. Harsh chemical and physical treatment generates process contaminants, and refined oils raise serum and tissue cholesterol in vivo independent of saturated fat content. We developed an in vitro bioassay for rapidly assessing the influence of oils on cholesterol metabolism in the human liver HepG2 cell line, and tested it using coconut oil (CO) of various stages of refinement. Read More

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http://dx.doi.org/10.1016/j.fct.2019.03.005DOI Listing

Adaptations to Coronary Physiology in a Patient With Severe Aortic Stenosis and Complete Heart Block Undergoing Transcatheter Aortic Valve Replacement.

JACC Cardiovasc Interv 2019 Mar 9. Epub 2019 Mar 9.

Monash Cardiovascular Research Centre and MonashHeart, Monash University and Monash Health, Melbourne, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jcin.2019.01.215DOI Listing

Opposing Wall Pushing and Stretching: Response to Cardiac Resynchronization Therapy Requires Electrical Delay and Viability.

JACC Cardiovasc Imaging 2019 Mar 8. Epub 2019 Mar 8.

Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, the Netherlands.

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http://dx.doi.org/10.1016/j.jcmg.2019.01.013DOI Listing

Cell signaling and biological pathway in cardiovascular diseases.

Arch Pharm Res 2019 Mar 15. Epub 2019 Mar 15.

National Research Laboratory for Stem Cell Niche, Center for Medical Innovation, Seoul National University Hospital, Seoul, 110-744, Republic of Korea.

Currently, coronary artery disease accounts for a large proportion of deaths occurring worldwide. Damage to the heart muscle over a short period of time leads to myocardial infarction (MI). The biological mechanisms of atherosclerosis, one of the causes of MI, have been well studied. Read More

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http://dx.doi.org/10.1007/s12272-019-01141-0DOI Listing

Initial experience with regadenoson stress positron emission tomography in patients with left bundle branch block: Low prevalence of septal defects and high accuracy for obstructive coronary artery disease.

J Nucl Cardiol 2019 Mar 14. Epub 2019 Mar 14.

Department of Cardiovascular Imaging, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, USA.

Background: Assessing for coronary artery disease (CAD) in patients with left bundle branch block (LBBB) is difficult with noninvasive cardiac imaging. Few studies report the prevalence of LBBB associated septal-apical perfusion defects using regadenoson stress on Positron Electron Tomography (PET) imaging.

Methods And Results: We identified 101 consecutive patients with baseline LBBB, and without known CAD, who underwent rest-stress regadenoson PET. Read More

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http://dx.doi.org/10.1007/s12350-019-01681-4DOI Listing

Conduction in the Right and Left Ventricle is Differentially Regulated by Protein Kinases and Phosphatases: Implications for Arrhythmogenesis.

Am J Physiol Heart Circ Physiol 2019 Mar 15. Epub 2019 Mar 15.

Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, United States.

The "stress kinases" cAMP-dependent protein kinase (PKA) and calcium/calmodulin-dependent protein kinase II (CaMKII), phosphorylate the Nachannel Nav1.5 subunit to regulate its function. However, how the channel regulation translates to ventricular conduction is poorly understood. Read More

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http://dx.doi.org/10.1152/ajpheart.00660.2018DOI Listing

The immunocytochemical expression of VE-1 (BRAF V600E-related) antibody identifies the aggressive variants of papillary thyroid carcinoma on liquid-based cytology.

Cytopathology 2019 Mar 15. Epub 2019 Mar 15.

Division of Anatomic Pathology and Histology Catholic, University of Sacred Heart, Foundation "Agostino Gemelli" University Hospital, Largo Francesco Vito 1, 00168, Rome, Italy.

Background: The recently introduced monoclonal V600E antibody (clone VE1) is likely to be an alternative strategy for detecting this mutation in thyroid lesions. Although VE1 immunostaining and molecular methods used to assess papillary thyroid carcinoma in surgical specimens are in good agreement, evaluation of VE1 in cytology and cell block samples is rarely performed, and its diagnostic value in cytology has not been well established. In this study, we sought to determine if VE1 is suitable for FNA and cell block method. Read More

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http://dx.doi.org/10.1111/cyt.12690DOI Listing

Congenital myopathies are mainly associated with a mild cardiac phenotype.

J Neurol 2019 Mar 14. Epub 2019 Mar 14.

Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Background: To evaluate the prevalence of cardiac involvement in patients with congenital myopathies and the association to specific genotypes.

Methods: We evaluated patients with physical examination, electrocardiogram, echocardiography, and 48-h Holter monitoring. Follow-up was performed for major events. Read More

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http://dx.doi.org/10.1007/s00415-019-09267-3DOI Listing

First Report of the Italian Registry on Immune-Mediated Congenital Heart Block (Lu.Ne Registry).

Front Cardiovasc Med 2019 28;6:11. Epub 2019 Feb 28.

Struttura Complessa Medicina Interna, ASST Papa Giovanni XXIII, Bergamo, Italy.

Neonatal Lupus (NL) is a rare syndrome caused by placental transfer of maternal anti-SSA/Ro and anti-La/SSB autoantibodies to the fetus. The rarity of this condition requires the establishment of multidisciplinary registries in order to improve our knowledge. Inclusion criteria in this retrospective study were the maternal confirmed positivity for anti-SSA/Ro and/or anti-SSB/La antibodies, and the presence of II or III degree congenital heart block (CHB) or neonatal period (up to 27 days after birth). Read More

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https://www.frontiersin.org/article/10.3389/fcvm.2019.00011/
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http://dx.doi.org/10.3389/fcvm.2019.00011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404544PMC
February 2019
1 Read

Cardiac Arrhythmias in Horses.

Authors:
Gunther van Loon

Vet Clin North Am Equine Pract 2019 Mar 11. Epub 2019 Mar 11.

Department of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke 9820, Belgium. Electronic address:

Arrhythmias are common in horses. Sinus arrhythmia and first- and second-degree atrioventricular block are frequently found physiologic arrhythmias, but should immediately disappear after stress or exercise. Atrial premature depolarizations are usually not associated with poor performance, but are a potential trigger for atrial fibrillation. Read More

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http://dx.doi.org/10.1016/j.cveq.2018.12.004DOI Listing

The FBXW7-SHOC2-Raptor Axis Controls the Cross-Talks between the RAS-ERK and mTORC1 Signaling Pathways.

Cell Rep 2019 Mar;26(11):3037-3050.e4

Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109, USA; Institute of Translational Medicine and Cancer Institute of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address:

FBXW7 is a tumor suppressive E3 ligase, whereas RAS-ERK and mechanistic target of rapamycin kinase (mTORC1) are two major oncogenic pathways. Whether and how FBXW7 regulates these two oncogenic pathways are unknown. Here, we showed that SHOC2, a RAS activator, is a FBXW7 substrate. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.02.052DOI Listing
March 2019
7.207 Impact Factor

Safety of an improved patent ductus arteriosus occluder for transcatheter closure of perimembranous ventricular septal defects with abnormally attached tricuspid chordae tendineae.

World J Clin Cases 2019 Mar;7(5):562-571

Department of Structural Heart Disease, Xi'an Jiaotong University Medical College First Affiliated Hospital, Xi'an 710061, Shaanxi Province, China.

Background: The off-label use of various devices has been reported for the transcatheter closure of perimembranous ventricular septal defects (PmVSD) because of serious complications, such as heart block and tricuspid regurgitation (TR), associated with conventional ventricular septal defect devices. However, whether certain defects such as PmVSD with abnormally attached tricuspid are fit for interventional treatment is still disputable.

Aim: To explore the feasibility and safety of transcatheter closure of PmVSD with abnormally attached tricuspid chordae tendineae using an improved patent ductus arteriosus (PDA) occluder. Read More

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https://www.wjgnet.com/2307-8960/full/v7/i5/562.htm
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http://dx.doi.org/10.12998/wjcc.v7.i5.562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406192PMC
March 2019
4 Reads

sST2: a new kid on the block for patients with ACHD.

Authors:
Oktay Tutarel

Heart 2019 Mar 12. Epub 2019 Mar 12.

Department of Paediatric Cardiology and Congenital Heart Disease, German Heart Centre Munich, Munich, Germany.

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http://dx.doi.org/10.1136/heartjnl-2019-314699DOI Listing

Bradyarrhythmia development and permanent pacemaker implantation after cardiac surgery.

North Clin Istanb 2018 8;5(4):288-294. Epub 2018 Aug 8.

Department of Cardiology, Health Science University Dr. Siyami Ersek Training and Research Hospital, Istanbul, Turkey.

Objective: Bradyarrhythmia is one of the complications that may develop after cardiac surgery. Only a few studies have previously dealt with this concern, and in our study, we investigated the factors affecting the development of atrioventricular block or sinus node dysfunction and the requirement of permanent pacemaker following cardiac surgery.

Methods: A total of 62 patients who developed the atrioventricular (AV) block or sinus node dysfunction and required a permanent pacemaker following cardiac surgery were included in the study. Read More

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http://dx.doi.org/10.14744/nci.2017.20438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371988PMC

Heart valve injury due to radiation therapy.

Kardiologiia 2019 Mar 7;59(2S):56-68. Epub 2019 Mar 7.

I. M. Sechenov First Moscow State Medical University (Sechenov University)..

Relevance: Radiation therapy (RT) plays an important role in oncology, improving the immediate and long-term results of treatment of a number of tumors. One of the most significant complications of RT are lesions of the heart valves.

Objective: To study the variants of valve damage that occur in patients who received radiation therapy for cancer. Read More

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http://dx.doi.org/10.18087/cardio.2656DOI Listing

Serum amyloid A levels are associated with polymorphic variants in the serum amyloid A 1 and 2 genes.

Ir J Med Sci 2019 Mar 9. Epub 2019 Mar 9.

Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland.

Background: Serum amyloid A (SAA) is secreted by liver hepatocytes in response to increased inflammation whereupon it associates with high-density lipoprotein (HDL) and alters the protein and lipid composition of HDL negating some of its anti-atherogenic properties.

Aims: To identify variants within the SAA gene that may be associated with SAA levels and/or cardiovascular disease (CVD).

Methods: We identified exonic variants within the SAA genes by deoxyribonucleic acid (DNA) Sanger sequencing. Read More

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http://dx.doi.org/10.1007/s11845-019-01996-8DOI Listing

Systemic sarcoidosis presenting as complete heart block in a patient with normal chest radiography.

BMJ Case Rep 2019 Mar 9;12(3). Epub 2019 Mar 9.

Cardiology, Albany Medical Center Hospital, Albany, New York, USA.

A previously healthy 44-year-old Caucasian man presented with recurrent syncope and was found to have a complete heart block with a ventricular rate of 24 bpm. No biochemical abnormalities were identified. Tick borne illnesses were ruled out. Read More

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http://dx.doi.org/10.1136/bcr-2018-227143DOI Listing

Enzymatic preparation of monoubiquitinated FANCD2 and FANCI proteins.

Methods Enzymol 2019 11;618:73-104. Epub 2019 Feb 11.

Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom; MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences University of Dundee, Dundee, United Kingdom. Electronic address:

In higher eukaryotes, DNA damage repair response pathways are orchestrated by several molecular signals including ubiquitination. In particular the repair of DNA interstrand crosslinks, toxic to transcription and replication processes, involve the activation of the Fanconi anemia repair pathway. At the heart of this pathway lies the monoubiquitination of FANCD2 and FANCI proteins, which triggers the recruitment of DNA repair factors. Read More

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http://dx.doi.org/10.1016/bs.mie.2018.12.021DOI Listing
February 2019
1 Read

Acute Effects of Interrupting Prolonged Sitting With Intermittent Physical Activity on Blood Pressure in Preadolescent Children.

Pediatr Exerc Sci 2019 Mar 8:1-8. Epub 2019 Mar 8.

1 University of Michigan.

Purpose: To compare the acute effects of intermittent physical activity (PA) across 4 different intensities on blood pressure.

Methods: Thirty children (12 males and 18 females; aged 7-11 y; 33% overweight/obese; 53% nonwhite) completed 4 experimental conditions in random order: 8 hours sitting interrupted with 20, 2-minute low-, moderate-, high-intensity PA breaks, or sedentary screen-time breaks. PA intensity corresponded with 25%, 50%, and 75% of heart rate reserve. Read More

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http://dx.doi.org/10.1123/pes.2018-0224DOI Listing
March 2019
1 Read

Mid-term outcomes of individualized surgeries in patients with Ebstein's anomaly.

Heart Vessels 2019 Mar 8. Epub 2019 Mar 8.

Department of Cardiothoracic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200092, China.

The variable anatomy of Ebstein's anomaly leads to its various surgical procedures. The long-term outcomes of different operations were not well established. Thirty-five patients with Ebstein's anomaly who underwent operations from 2006 to 2018 in our department were retrospectively reviewed. Read More

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http://dx.doi.org/10.1007/s00380-019-01358-5DOI Listing
March 2019
3 Reads

Potent immunomodulation and angiogenic effects of mesenchymal stem cells versus cardiomyocytes derived from pluripotent stem cells for treatment of heart failure.

Stem Cell Res Ther 2019 Mar 7;10(1):78. Epub 2019 Mar 7.

Cardiology Division, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Rm 1928, Block K, Hong Kong SAR, China.

Background: Optimal cell type as cell-based therapies for heart failure (HF) remains unclear. We sought to compare the safety and efficacy of direct intramyocardial transplantation of human embryonic stem cell-derived cardiomyocytes (hESC-CMs) and human induced pluripotent stem cell-derived mesenchymal stem cells (hiPSC-MSCs) in a porcine model of HF.

Methods: Eight weeks after induction of HF with myocardial infarction (MI) and rapid pacing, animals with impaired left ventricular ejection fraction (LVEF) were randomly assigned to receive direct intramyocardial injection of saline (MI group), 2 × 10 hESC-CMs (hESC-CM group), or 2 × 10 hiPSC-MSCs (hiPSC-MSC group). Read More

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http://dx.doi.org/10.1186/s13287-019-1183-3DOI Listing
March 2019
1 Read

Second-degree interatrial block: A case series.

J Electrocardiol 2019 Feb 7;54:18-21. Epub 2019 Feb 7.

Division of Cardiology, Kingston Health Science Center, Queen's University, Kingston, Ontario, Canada.

Advanced interatrial block (IAB) (P-wave ≥120 ms and biphasic P-wave in leads II, III and aVF) is a prevalent ECG pattern frequently associated with supraventricular arrhythmias and stroke, especially in patients with structural heart disease. Intermittent IAB is a much more poorly defined electrocardiographic entity with uncertain clinical significance. In this case series, we review and analyze eight cases of second degree intermittent IAB. Read More

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http://dx.doi.org/10.1016/j.jelectrocard.2019.02.001DOI Listing
February 2019
1 Read

Electrocardiographic Findings in Peripartum Cardiomyopathy.

Clin Cardiol 2019 Mar 7. Epub 2019 Mar 7.

Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Background: There is limited data on electrocardiographic (ECG) abnormalities and their prognostic significance in women with peripartum cardiomyopathy (PPCM). We sought to characterize ECG findings in PPCM and explore the association of ECG findings with myocardial recovery and clinical outcomes.

Hypothesis: We hypothesized that ECG indicators of myocardial remodeling would portend worse systolic function and outcomes. Read More

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http://dx.doi.org/10.1002/clc.23171DOI Listing
March 2019
4 Reads

Identification of a novel class of RIP1/RIP3 dual inhibitors that impede cell death and inflammation in mouse abdominal aortic aneurysm models.

Cell Death Dis 2019 Mar 6;10(3):226. Epub 2019 Mar 6.

Department of Surgery, School of Medicine and Public Health, University of Wisconsin, Madison, WI, 53705, USA.

Receptor interacting protein kinase-1 and -3 (RIP1 and RIP3) are essential mediators of cell death processes and participate in inflammatory responses. Our group recently demonstrated that gene deletion of Rip3 or pharmacological inhibition of RIP1 attenuated pathogenesis of abdominal aortic aneurysm (AAA), a life-threatening degenerative vascular disease characterized by depletion of smooth muscle cells (SMCs), inflammation, negative extracellular matrix remodeling, and progressive expansion of aorta. The goal of this study was to develop drug candidates for AAA and other disease conditions involving cell death and inflammation. Read More

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http://dx.doi.org/10.1038/s41419-019-1468-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403222PMC
March 2019
1 Read

BRD4 directs hematopoietic stem cell development and modulates macrophage inflammatory responses.

EMBO J 2019 Mar 6. Epub 2019 Mar 6.

Division of Developmental Biology, National Institute of Child Health and Human Development, Bethesda, MD, USA

BRD4 is a BET family protein that binds acetylated histones and regulates transcription. BET/BRD4 inhibitors block blood cancer growth and inflammation and serve as a new therapeutic strategy. However, the biological role of BRD4 in normal hematopoiesis and inflammation is not fully understood. Read More

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http://dx.doi.org/10.15252/embj.2018100293DOI Listing
March 2019
4 Reads

Interlead electrical delays and scar tissue; response to cardiac resynchronization therapy in patients with ischemic cardiomyopathy.

Pacing Clin Electrophysiol 2019 Mar 6. Epub 2019 Mar 6.

Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Background: The importance of interlead electrical delays (IEDs) in the presence of scar tissue for response to cardiac resynchronization therapy (CRT) in patients with ischemic cardiomyopathy is poorly described.

Methods: Sixty-eight CRT patients with ischemic cardiomyopathy and left bundle branch block were included. IEDs, the time between sensing of native impulse at the RV-lead and LV-lead, were measured at implantation and after eight months. Read More

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http://dx.doi.org/10.1111/pace.13652DOI Listing

GNAI1 and GNAI3 Reduce Colitis-Associated Tumorigenesis in Mice by Blocking IL6 Signaling and Downregulating Expression of GNAI2.

Gastroenterology 2019 Mar 2. Epub 2019 Mar 2.

Cancer Biology Program, University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, HI 96813; The Second Affiliated Hospital, The State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology, Guangzhou Medical University, Guangzhou 510260, Guangdong, China. Electronic address:

Background & Aims: Interleukin 6 (IL6) and tumor necrosis factor (TNF) contribute to the development of colitis-associated cancer (CAC). We investigated these signaling pathways and the involvement of G protein subunit alpha i1 (GNAI1), GNAI2, and GNAI3 in the development of CAC in mice and humans.

Methods: B6;129 wild-type (control) or mice with disruption of Gnai1, Gnai2, and/or Gnai3 or conditional disruption of Gnai2 in CD11c+ or epithelial cells were given dextran sulfate sodium (DSS) to induce colitis followed by azoxymethane (AOM) to induce carcinogenesis; some mice were given an antibody against IL6. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.02.040DOI Listing
March 2019
1 Read

Relationship of Neighborhood Greenness to Heart Disease in 249 405 US Medicare Beneficiaries.

J Am Heart Assoc 2019 Mar;8(6):e010258

1 University of Miami Miller School of Medicine Miami FL.

Background Nature exposures may be associated with reduced risk of heart disease. The present study examines the relationship between objective measures of neighborhood greenness (vegetative presence) and 4 heart disease diagnoses (acute myocardial infarction, ischemic heart disease, heart failure, and atrial fibrillation) in a population-based sample of Medicare beneficiaries. Methods and Results The sample included 249 405 Medicare beneficiaries aged 65 years and older whose location ( ZIP +4) in Miami-Dade County, Florida, did not change from 2010 to 2011. Read More

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http://dx.doi.org/10.1161/JAHA.118.010258DOI Listing
March 2019
4 Reads

Thanatometabolomics: introducing NMR-based metabolomics to identify metabolic biomarkers of the time of death.

Metabolomics 2019 Mar 5;15(3):37. Epub 2019 Mar 5.

Department of Food and Nutritional Sciences, The University of Reading, Whiteknights Campus, Reading, RG6 6AP, UK.

Introduction: Death is the permanent cessation of the critical functions of the organism as a whole. However, the shutdown of a complex biological organism does not abruptly terminate at time of death. New high-throughput technologies allow the systematic investigation of the biochemical modulations occurring after death. Read More

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http://dx.doi.org/10.1007/s11306-019-1498-1DOI Listing
March 2019
1 Read

Cardiovascular Risk in Middle-Aged and Older Immigrants: Exploring Residency Period and Health Insurance Coverage.

J Nurs Scholarsh 2019 Mar 4. Epub 2019 Mar 4.

Upsilon, Mathy Mezey Professor of Geriatric Nursing, New York University Rory Meyers College of Nursing, New York, NY, USA.

Purpose: It is reported that while immigrants are, initially, healthier than the native-born upon resettlement, this advantage erodes over time. In the United States, uninsured aging immigrants are increasingly experiencing severe complications of cardiovascular disease (CVD). The purpose of this study was to compare overall CVD risk and explore the importance of health insurance coverage on CVD risk relative to other health access barriers, from 2007 to 2012, in recent and long-term immigrants >50 years of age. Read More

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http://dx.doi.org/10.1111/jnu.12465DOI Listing

Preoperative Cardiac Stress Tests Ordered in the Preoperative Evaluation Clinic: A Retrospective Review of Ordering Patterns.

Cardiol Res 2019 Feb 24;10(1):1-8. Epub 2019 Feb 24.

Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital/Harvard Medical School, 75 Francis Street, CWN-L1, Boston, MA 02115, USA.

Background: The role of anesthesiologists has expanded from operating rooms to preoperative evaluation clinics. This role involves performing preoperative cardiovascular evaluation and optimization of patients before elective surgery, which can include ordering cardiac stress tests. We aimed to study the ordering patterns by anesthesiologists for preoperative cardiac stress tests, focusing on whether societal and institutional guidelines and recommendations were used. Read More

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http://dx.doi.org/10.14740/cr821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396798PMC
February 2019

Glycosphingolipids promote pro-atherogenic pathways in the pathogenesis of hyperglycemia-induced accelerated atherosclerosis.

Metabolomics 2018 Jul 3;14(7):92. Epub 2018 Jul 3.

Thrombosis and Atherosclerosis Research Institute, McMaster University, 237 Barton Street East, Hamilton, ON, L8L 2X2, Canada.

Introduction: Three out of four people with diabetes will die of cardiovascular disease. However, the molecular mechanisms by which hyperglycemia promotes atherosclerosis, the major underlying cause of cardiovascular disease, are not clear.

Objectives: Three distinct models of hyperglycemia-associated accelerated atherosclerosis were used to identify commonly altered metabolites and pathways associated with the disease. Read More

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http://dx.doi.org/10.1007/s11306-018-1392-2DOI Listing

Left ventricular vortex formation time in elite athletes.

Int J Cardiovasc Imaging 2019 Mar 2. Epub 2019 Mar 2.

Department of Cardiology, National University Heart Centre Singapore, National University Health System, Singapore, 1E Kent Ridge Rd, NUHS Tower Block, Level 9, Singapore, 119228, Singapore.

Vortex formation time (VFT) is a continuous measure of the left ventricular (LV) filling that integrates all phases of diastole. This has been previously studied in patients with heart failure. This study examined the differences in VFT between healthy controls and elite athletes. Read More

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http://dx.doi.org/10.1007/s10554-019-01561-5DOI Listing
March 2019
1 Read

Increased risk of late pacemaker implantation after ablation for atrioventricular nodal reentry tachycardia. A 10-year follow up of a nationwide cohort.

Heart Rhythm 2019 Feb 28. Epub 2019 Feb 28.

Heart Centre and Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.

Background: Catheter ablation of the slow pathway is standard treatment for atrioventricular nodal reentry tachycardia (AVNRT), with a well-described, low risk for periprocedural atrioventricular block. Less is known about the risk of pacemaker implantation late after ablation.

Objective: We aimed to quantify the risk of late pacemaker-implantation in a countrywide cohort undergoing first-time ablation for AVNRT. Read More

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http://dx.doi.org/10.1016/j.hrthm.2019.02.032DOI Listing
February 2019
1 Read

The influence of hERG1a and hERG1b isoforms on drug safety screening in iPSC-CMs.

Prog Biophys Mol Biol 2019 Feb 27. Epub 2019 Feb 27.

Department of Medical Physiology, Division Heart & Lungs, University Medical Center Utrecht, the Netherlands. Electronic address:

The human Ether-à-go-go Related Gene (hERG) encodes the pore forming subunit of the channel that conducts the rapid delayed rectifier potassium current I. I drives repolarization in the heart and when I is dysfunctional, cardiac repolarization delays, the QT interval on the electrocardiogram (ECG) prolongs and the risk of developing lethal arrhythmias such as Torsade de Pointes (TdP) increases. TdP risk is incorporated in drug safety screening for cardiotoxicity where hERG is the main target since the I channels appear highly sensitive to blockage. Read More

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http://dx.doi.org/10.1016/j.pbiomolbio.2019.02.003DOI Listing
February 2019
2 Reads

Clinical comparison of two techniques of brachial plexus block for forelimb surgery in dogs.

Vet J 2019 Feb 5;244:23-27. Epub 2018 Dec 5.

The Royal Veterinary College, North Mymms, Hartfield, Hertfordshire AL9 7TA, United Kingdom. Electronic address:

The objective of this study was to compare two different local anaesthesia techniques for intraoperative analgesia in dogs undergoing surgical procedures distal to the mid humeral diaphysis. Thirty-two dogs were divided into two groups: the US group received an ultrasound-guided brachial plexus block at the level of the first rib and the N group received a neurostimulation-guided paravertebral brachial plexus block. Ropivacaine 0. Read More

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http://dx.doi.org/10.1016/j.tvjl.2018.12.001DOI Listing
February 2019

Unusual conservative treatment of a complicated pacemaker pocket infection: a case report.

J Med Case Rep 2019 Mar 3;13(1):49. Epub 2019 Mar 3.

The First Clinical Medical College of Jinan University, Guangzhou, 510630, China.

Background: For patients with complicated generator pocket infection, expert consensuses universally advocate complete device and leads removal followed by delayed replacement on the contralateral side. We cured our patient by partial generator removal and reimplantation of sterilized pulse generator on the ipsilateral side. We also performed a literature review about incomplete removal therapy for the management of cardiac implantable electronic device infection. Read More

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http://dx.doi.org/10.1186/s13256-019-1987-xDOI Listing
March 2019
2 Reads

Serial Cardiac FDG-PET for the Diagnosis and Therapeutic Guidance of Patients with Cardiac Sarcoidosis.

J Card Fail 2019 Feb 27. Epub 2019 Feb 27.

Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA. Electronic address:

Background: Cardiac fluorodeoxyglucose positron emission tomography (FDG-PET) has emerged as a standard imaging modality for the diagnosis of cardiac sarcoidosis (CS); however, there is a scarcity of data on the use of serial FDG-PET to guide immunosuppressive therapy.

Objectives: To report our experience in using serial FDG-PET for the diagnosis and management of patients with CS, focusing on its utility in ongoing immunosuppression management.

Methods: We studied consecutive patients with CS managed at Stanford University from 2010-2017. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10719164193020
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http://dx.doi.org/10.1016/j.cardfail.2019.02.018DOI Listing
February 2019
2 Reads

Use of atracurium and its reversal with neostigmine in 14 pet rabbits undergoing ophthalmic surgery: a retrospective study.

Vet Rec 2019 Mar 1. Epub 2019 Mar 1.

Department of Clinical Sciences and Services, Royal Veterinary College, University of London, Hatfield, Hertfordshire AL97TA, UK.

The objective of this retrospective study was to report the clinical use of atracurium and its reversal with neostigmine in pet rabbits. The medical records of 14 rabbits undergoing anaesthesia for ophthalmic surgery were located through a search of the hospital's database. Demographic data and data pertaining to the use of the neuromuscular blocker and its reversal were analysed. Read More

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http://dx.doi.org/10.1136/vr.105266DOI Listing

Hypertensive Retinopathy: A Prognostic Factor for Morbidity and Mortality after Acute ST Elevation Myocardial Infarction.

J Coll Physicians Surg Pak 2019 Mar;29(3):205-209

Cardiology Unit, Lady Reading Hospital, Peshawar, Pakistan.

Objective: To determine the association between hypertensive retinopathy (HR) and post ST elevation myocardial infarction (STEMI) complications among successfully thrombolysed patients.

Study Design: A cohort study.

Place And Duration Of Study: Cardiology Unit, Lady Reading Hospital, Peshawar, from June 2016 to December 2017. Read More

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http://dx.doi.org/10.29271/jcpsp.2019.03.205DOI Listing
March 2019
4 Reads

Prenatal diagnosis and management of congenital complete heart block.

Birth Defects Res 2019 Mar 1. Epub 2019 Mar 1.

Department of Obstetrics and Gynecology/Division of Maternal Fetal Medicine, Keck School of Medicine of USC, Los Angeles, California.

Congenital complete heart block (CCHB) is a life-threatening medical condition in the unborn fetus with insufficiently validated prenatal interventions. Maternal administration of medications aimed at decreasing the immune response in the fetus and beta-agonists intended to increase fetal cardiac output have shown only marginal benefits. Anti-inflammatory therapies cannot reverse CCHB, but may decrease myocarditis and improve heart function. Read More

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http://dx.doi.org/10.1002/bdr2.1459DOI Listing
March 2019
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Epidural analgesia for adults undergoing cardiac surgery with or without cardiopulmonary bypass.

Cochrane Database Syst Rev 2019 Mar 1;3:CD006715. Epub 2019 Mar 1.

Department of Anesthesiology, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada.

Background: General anaesthesia combined with epidural analgesia may have a beneficial effect on clinical outcomes. However, use of epidural analgesia for cardiac surgery is controversial due to a theoretical increased risk of epidural haematoma associated with systemic heparinization. This review was published in 2013, and it was updated in 2019. Read More

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http://dx.doi.org/10.1002/14651858.CD006715.pub3DOI Listing
March 2019
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His Bundle Pacing in Heart Failure-Concept and Current Data.

Curr Heart Fail Rep 2019 Feb;16(1):47-56

Indiana University, Indianapolis, IN, USA.

Purpose Of Review: His bundle pacing (HBP) has continued to emerge as a viable alternative to both right ventricular pacing (RVP) and cardiac resynchronization therapy. In recent years, a considerable amount of research has been published with regard to using HBP to treat congestive heart failure (CHF) and this article presents a concise yet comprehensive review of this literature.

Recent Findings: Studies have demonstrated that HBP is useful for CHF patients who are non-responders to biventricular pacing (BiVP) or have a history of previously failed coronary sinus lead placement, right/left bundle branch block cardiomyopathy, or pacing-induced cardiomyopathy. Read More

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http://dx.doi.org/10.1007/s11897-019-0423-2DOI Listing
February 2019

Dichotomous roles of in the establishment of atrioventricular conduction pathways in the human heart.

HeartRhythm Case Rep 2019 Feb 20;5(2):109-111. Epub 2018 Nov 20.

Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri.

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http://dx.doi.org/10.1016/j.hrcr.2018.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379565PMC
February 2019
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Fetal arrhythmias: Diagnosis and management.

Indian Pacing Electrophysiol J 2019 Feb 25. Epub 2019 Feb 25.

Department of Pediatrics, Oregon Health & Science University, Portland, OR, USA.

This article reviews important features for improving the diagnosis and management of fetal arrhythmias. The normal fetal heart rate ranges between 110 and 160 beats per minute. A fetal heart rate is considered abnormal if the heart rate is beyond the normal ranges or the rhythm is irregular. Read More

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http://dx.doi.org/10.1016/j.ipej.2019.02.007DOI Listing
February 2019
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Comparison of intraperitoneal bupivacaine, acetazolamide, and placebo on pain relief after laparoscopic cholecystectomy surgery: A clinical trial.

Med J Islam Repub Iran 2018 13;32:112. Epub 2018 Nov 13.

Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

Given the importance of patients' pain after laparoscopic surgeries, this study was conducted to compare the effectiveness of intraperitoneal bupivacaine, acetazolamide, and placebo on pain relief after laparoscopic cholecystectomy surgery. Patients admitted to Rasool Akram hospital with physical status I or II, based on the American Society of Anesthesiologists (ASA) system, who were candidates for laparoscopic cholecystectomy surgery due to gallstones, were included in this study. Patients were divided into 3 groups (each group containing 20 patients) using block randomization with foursome blocks. Read More

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http://dx.doi.org/10.14196/mjiri.32.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387819PMC
November 2018
1 Read

A Wavelet Transform-Based Neural Network Denoising Algorithm for Mobile Phonocardiography.

Sensors (Basel) 2019 Feb 24;19(4). Epub 2019 Feb 24.

Blekinge Institute of Technology, Institute of Applied Signal Processing, 371 79 Karlskrona, Sweden.

Cardiovascular pathologies cause 23.5% of human deaths, worldwide. An auto-diagnostic system monitoring heart activity, which can identify the early symptoms of cardiac illnesses, might reduce the death rate caused by these problems. Read More

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http://dx.doi.org/10.3390/s19040957DOI Listing
February 2019

Early characteristics of fulminant myocarditis vs non-fulminant myocarditis: A meta-analysis.

Medicine (Baltimore) 2019 Feb;98(8):e14697

Department of Cardiology.

Background: Fulminant myocarditis (FM) is a sub-category myocarditis. Its primary characteristic is a rapidly progressive clinical course that necessitates hemodynamic support. FM can be difficult to predict at the onset of myocarditis. Read More

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http://dx.doi.org/10.1097/MD.0000000000014697DOI Listing
February 2019