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    Impact of medication adherence on risk of ischemic stroke, major bleeding, and deep vein thrombosis in atrial fibrillation patients using novel oral anticoagulants.
    Curr Med Res Opin 2018 Jan 16:1-17. Epub 2018 Jan 16.
    a Department of Pharmacy Practice , College of Pharmacy, University of Rhode Island , Kingston , RI , US.
    Objectives: Our study examined the impact of adherence to Novel Oral Anticoagulants (dabigatran and rivaroxaban) [NOACs] on ischemic-stroke (IS), major-bleeding (MB), deep-vein-thrombosis and pulmonary-embolism (DVTPE) risk in a large, nationwide, propensity-matched sample.

    Methods: A retrospective cohort study utilized data from a US commercial insurance database (2010-2012). Adults patients with ≥1 diagnosis of atrial fibrillation/flutter (ICD-9 427. Read More

    Contemporary Procedural Complications, Hospitalizations, and Emergency Visits After Catheter Ablation for Atrial Fibrillation.
    Am J Cardiol 2017 Dec 14. Epub 2017 Dec 14.
    Division of Research, Kaiser Permanente Northern California, Oakland, California; Departments of Epidemiology, Biostatistics, and Medicine, UCSF, San Francisco, California; Department of Health Research and Policy, Stanford School of Medicine, Stanford, California.
    Contemporary data on complications and resource utilization after atrial fibrillation (AF) ablation are limited. We evaluated rates and risk factors for procedural complication, rehospitalization, and emergency department visits after AF ablation. We identified all adult patients who underwent isolated AF ablation between 2010 and June 2014 in 2 large integrated health-care delivery systems and evaluated rates of acute inpatient complication, 30-day, and 1-year readmission and emergency evaluation. Read More

    The impact of non-vitamin K antagonist oral anticoagulants (NOACs) on anticoagulation therapy in rural Australia.
    Med J Aust 2018 Jan;208(1):18-23
    University of Western Australia, Perth, WA.
    Objective: To determine the use of different anticoagulation therapies in rural Western Australia; to establish whether remoteness from health care services affects the choice of anticoagulation therapy; to gather preliminary data on anticoagulation therapy safety and efficacy.

    Design: Retrospective cohort study of patients hospitalised with a principal diagnosis of atrial fibrillation/flutter (AF) or venous thromboembolism (VTE) during 2014-2015.

    Setting: Four hospitals serving two-thirds of the rural population of Western Australia. Read More

    Thirty-Day Readmissions After Cardiac Implantable Electronic Devices in the United States: Insights from the Nationwide Readmissions Database.
    Heart Rhythm 2018 Jan 6. Epub 2018 Jan 6.
    Division of Cardiology, Lehigh Valley Health Network, Allentown, PA; Department of Medicine, Sinai Hospital of Baltimore, Baltimore, MD; Queens Cardiac Care, Queens, NY; Department of Cardiology, Virginia Commonwealth University School of Medicine, Richmond, Virginia.
    Background: Limited data are available regarding true estimates of individual complications contributing to readmissions after cardiac implantable electronic device (CIED) implantation.

    Objective: We aimed to identify predictors of 30-day readmission in patients admitted for CIED implantation.

    Methods: The study cohort consisted of patients who received CIED implantation in 2014, identified from National Readmission Database. Read More

    Percutaneous Closure Versus Medical Treatment in Stroke Patients With Patent Foramen Ovale: A Systematic Review and Meta-analysis.
    Ann Intern Med 2018 Jan 9. Epub 2018 Jan 9.
    From Magna Graecia University, Catanzaro, Italy; Cardiovascular Center Frankfurt, Frankfurt, Germany, and Anglia Ruskin University, Cambridge and Chelmsford, United Kingdom; and Magna Graecia University and Consiglio Nazionale delle Ricerche, Catanzaro, Italy.
    Background: New evidence emerged recently regarding the percutaneous closure of patent foramen ovale (PFO) to prevent recurrent stroke in patients with cryptogenic stroke.

    Purpose: To compare risks for recurrent cerebrovascular events in adults with PFO and cryptogenic stroke who underwent PFO closure versus those who received medical therapy alone.

    Data Sources: PubMed, Scopus, and Google Scholar from 1 December 2004 through 14 September 2017; references of eligible studies; relevant scientific session abstracts; and cardiology Web sites. Read More

    The Frequency and Risk Factors for Ischemic Stroke in Myotonic Dystrophy Type 1 Patients.
    J Stroke Cerebrovasc Dis 2018 Jan 3. Epub 2018 Jan 3.
    Department of Neurology, Asahikawa Medical Center, National Hospital Organization, Asahikawa, Hokkaido, Japan.
    Introduction: Patients with myotonic dystrophy type 1 have several cardiac abnormalities, especially myocardial conduction disorders. Few studies have investigated cerebral infarction. We investigated the frequency of both symptomatic and asymptomatic ischemic strokes in patients with myotonic dystrophy type 1. Read More

    Clinical effectiveness of a systematic "pill-in-the-pocket" approach for the management of paroxysmal atrial fibrillation.
    Heart Rhythm 2018 Jan;15(1):9-16
    Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, Canada.
    Background: For patients with symptomatic, sustained atrial fibrillation (AF), a "pill-in-the-pocket" antiarrhythmic drug (PIP-AAD) strategy has been proposed to reduce emergency department (ED) use.

    Objective: To assess the clinical utility of a protocolled PIP-AAD approach within contemporary practice.

    Methods: Consecutive patients who hemodynamically tolerated symptomatic, sustained AF were prospectively managed with the PIP-AAD strategy. Read More

    A case of probable Amiodarone-induced pancreatitis in the treatment of atrial fibrillation: a literature review and case report.
    J Community Hosp Intern Med Perspect 2017 14;7(6):369-371. Epub 2017 Dec 14.
    Department of Internal Medicine, Tower Health: Reading Hospital, Reading, PA, USA.
    Amiodarone is an effective medication used in the treatment of several different arrhythmias. Its most well-known adverse effects include pulmonary fibrosis, thyroid dysfunction, and hepatotoxicity. A less common side effect is acute pancreatitis. Read More

    Geometric patterns of time-delay plots from different cardiac rhythms and arrhythmias using short-term EKG signals.
    Clin Physiol Funct Imaging 2017 Dec 27. Epub 2017 Dec 27.
    Department of Electrophysiology and Cardiology, Bernardino Rivadavia Hospital, Buenos Aires, Argentina.
    Objective: To date, no systematic work has been intended to describe spatio-temporal patterns of cardiac rhythms using only short series of RR intervals, to facilitate visual or computerized-aided identification of EKG motifs for use in clinical practice. The aim of this study was to detect and classify eye-catching geometric patterns of Poincaré time-delay plots from different types of cardiac rhythms and arrhythmias using short-term EKG signals.

    Methods: Approximately 150-300 representative, consecutive beats were retrieved from 24-h Holter registers of 100 patients with different heart rhythms. Read More

    Twitching of the Pacemaker Pocket Induced by Radiofrequency Energy Delivery to the Cavotricuspid Isthmus.
    Intern Med 2017 Dec 21. Epub 2017 Dec 21.
    Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Japan.
    An 82-year-old man with a permanent pacemaker (PM) implanted for sick sinus syndrome complained of palpitation due to paroxysmal atrial fibrillation and flutter. During extensive pulmonary vein isolation, the atrial lead was dislodged to the level of the tricuspid annulus. Radiofrequency energy delivery to the cavotricuspid isthmus reproducibly caused twitching of the PM pocket. Read More

    Prevalence of electrocardiographic abnormalities in primary care patients according to sex and age group. A retrospective observational study.
    Sao Paulo Med J 2017 Dec 18. Epub 2017 Dec 18.
    MD, MSc, PhD. Associate Professor, Department of Internal Medicine, Medical School, Universidade Federal de Minas Gerais, Belo Horizonte (MG), Brazil.
    Background: Knowledge of the prevalence of electrocardiographic abnormalities in a population is useful for interpreting the findings. The aim here was to assess the prevalence of electrocardiographic abnormalities and self-reported comorbidities and cardiovascular risk factors according to sex and age group among Brazilian primary care patients.

    Design And Setting: Observational retrospective study on consecutive primary care patients in 658 cities in the state of Minas Gerais, Brazil, whose digital electrocardiograms (ECGs) were sent for analysis to the team of the Telehealth Network of Minas Gerais (TNMG). Read More

    Evaluating the Utility of mHealth ECG Heart Monitoring for the Detection and Management of Atrial Fibrillation in Clinical Practice.
    J Atr Fibrillation 2017 Feb-Mar;9(5):1546. Epub 2017 Feb 28.
    Senior Faculty.
    Background: Little attention has focused on the integration of mobile health (mHealth) technology with self-management approaches to improve the detection and management of atrial fibrillation (AF) in clinical practice.

    Objective: The objective of this study was to investigate the differences between mHealth and usual care over a 6-month follow-up period among patients with a known history of atrial fibrillation.

    Methods: A pilot cohort from within the larger ongoing randomized trial, iPhone® Helping Evaluate Atrial fibrillation Rhythm through Technology (iHEART), was evaluated to determine differences in detection of AF and atrial flutter (AFL) recurrence rates (following treatment to restore normal rhythm) between patients undergoing daily smartphone ECG monitoring and age and gender matched control patients. Read More

    Postpacing Interval During Right Ventricular Overdrive Pacing to Discriminate Supraventricular from Ventricular tachycardia.
    J Atr Fibrillation 2017 Aug-Sep;10(2):1619. Epub 2017 Aug 31.
    Istanbul University, Istanbul Faculty of Medicine, Department of Cardiology, Istanbul-Turkey.
    Introduction: Failure to differentiate supraventricular from ventricular arrhythmias is the most frequent cause of inappropriate implantable cardioverter-defibrillator (ICD) therapies. We hypothesized that the postpacing interval (PPI) after overdrive right ventricular pacing may differentiate ventricular (VT) from supraventricular tachycardia (SVT) such as sinus tachycardia, atrial flutter and atrial tachycardia. This hypothesis is based on the entrainment maneuver. Read More

    Routine use of intracardiac echocardiography for atrial flutter ablation is associated with reduced fluoroscopy time, but not with a reduction of radiofrequency energy delivery time.
    J Atr Fibrillation 2017 Aug-Sep;10(2):1553. Epub 2017 Aug 31.
    Cardiocenter, Department of Cardiology, 3rd Faculty of Medicine, Charles University and University Hospital KralovskeVinohrady Prague, Czech Republic.
    Background: The ablation of cavotricuspid-isthmus (CTI) atrial flutter (AFL) dependent atrial flutter could be difficult in patients with complex anatomy of the CTI.The aim of the study was to assess whether the use of intracardiac echocardiography (ICE) was associated with less fluoroscopy time and faster ablations of cavotricuspid isthmus dependent atrial flutter (CTI-AFL).

    Methods: Patients with an indication for an ablation of a CTI-AFL were enrolled. Read More

    Atrial Fibrillation in Patients with Congenital Heart Disease.
    J Atr Fibrillation 2017 Jun-Jul;10(1):1612. Epub 2017 Jun 30.
    Adult Congenital Cardiology, Phoenix Children's Hospital, Phoenix, AZ.
    Advances in surgical techniques have led to the survival of most patients with congenital heart disease (CHD) up to their adulthood. During their lifetime, many of them develop atrial tachyarrhythmias due to atrial dilatation and scarring from surgical procedures. More complex defects and palliative repairs are linked to a higher incidence and earlier occurrence of arrhythmias. Read More

    First-Line Antiarrhythmic Transplacental Treatment for Fetal Tachyarrhythmia: A Systematic Review and Meta-Analysis.
    J Am Heart Assoc 2017 Dec 15;6(12). Epub 2017 Dec 15.
    The Heart Institute Cincinnati Children's Hospital Medical Center, Cincinnati, OH
    Background: There is no consensus on the most effective and best tolerated first-line antiarrhythmic treatment for fetal tachyarrhythmia. The purpose of this systematic review and meta-analysis was to compare the efficacy, safety, and fetal-maternal tolerance of first-line monotherapies for fetal supraventricular tachycardia and atrial flutter.

    Methods And Results: A comprehensive search of several databases was conducted through January 2017. Read More

    The athlete's heart is a proarrhythmic heart, and what that means for clinical decision making.
    Europace 2017 Dec 13. Epub 2017 Dec 13.
    Department of Cardiology, Antwerp University and University Hospital Antwerp, Wilrijkstraat 10, 2650 Edegem, Belgium.
    Recurring questions when dealing with arrhythmias in athletes are about the cause of the arrhythmia and, more importantly, about the eligibility of the athlete to continue sports activities. In essence, the relation between sports and arrhythmias can be understood along three lines: sports as arrhythmia trigger on top of an underlying problem, sports as arrhythmic substrate promotor, or sports as substrate inducer. Often, there is no sharp divider line between these entities. Read More

    Efficacy and safety comparison between different types of novel design enhanced open-irrigated ablation catheters in creating cavo-tricuspid isthmus block.
    J Cardiol 2017 Nov 24. Epub 2017 Nov 24.
    Cardiovascular Center, Tsuchiura Kyodo Hospital, Tsuchiura, Ibaraki, Japan.
    Background: Clinical utility of irrigation-tip ablation catheters for cavo-tricuspid isthmus (CTI) ablation is established. Recently, new-generation enhanced-cooling irrigation-tip catheters were introduced into clinical use. This study compared the performance of different types of novel irrigation-tip catheters in CTI ablation. Read More

    Colchicine for Prevention of Perioperative Atrial Fibrillation in patients undergoing lung resection surgery: a pilot randomized controlled study.
    Eur J Cardiothorac Surg 2017 Dec 9. Epub 2017 Dec 9.
    Department of Medicine, Hamilton General Hospital, Population Health Research Institute, Hamilton, ON, Canada.
    Objectives: We carried out a pilot randomized controlled study to determine the feasibility of a large trial evaluating the impact of colchicine versus placebo on postoperative atrial fibrillation or atrial flutter (POAF) among patients undergoing lung resection surgery.

    Methods: Patients ≥55 years of age undergoing lung resection surgery were randomly assigned to receive colchicine 0.6 mg or placebo starting a few hours before surgery. Read More

    Patent Foramen Ovale Closure for Secondary Prevention of Cryptogenic Stroke: Updated Meta-Analysis of Randomized Clinical Trials.
    Am J Med 2017 Dec 8. Epub 2017 Dec 8.
    Brigham and Women's Hospital Heart & Vascular Center and Harvard Medical School, Boston, MA, USA. Electronic address:
    Background: Patent foramen ovale closure represents a potential secondary prevention strategy for cryptogenic stroke, but available trials have varied by size, device studied, and follow-up.

    Methods: We conducted a systematic search of published randomized clinical trials (RCTs) evaluating patent foramen ovale closure vs. medical therapy in patients with recent stroke or transient ischemic attack using PubMED, EMBASE, and Cochrane through September 2017. Read More

    [Papillary fibroelastoma: retrospective analysis. Clinical presentation and surgical results].
    Medicina (B Aires) 2017 ;77(6):481-485
    Instituto de Cardiología y Cirugía Cardiovascular (ICYCC), Hospital Universitario Fundación Favaloro, Buenos Aires, Argentina.
    Papillary ibroelastomas are small benign intracardiac tumors known for their embolic potential. Since the introduction of echocardiography with improved resolution and transesophageal imaging techniques, they are being increasingly detected in clinical practice. In recent series, papillary fibroelastoma is considered the most frequent benign tumor of the heart. Read More

    Comparative Risks of Ischemic Stroke in Atrial Flutter versus Atrial Fibrillation.
    J Stroke Cerebrovasc Dis 2017 Dec 6. Epub 2017 Dec 6.
    Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute, New York, New York; Department of Neurology, Weill Cornell Medicine, New York, New York.
    Introduction: The aim of this study was to compare the risk of ischemic stroke in patients who have atrial fibrillation and patients who have atrial flutter.

    Methods: Using inpatient and outpatient Medicare claims data from 2008 to 2014 for a 5% sample of all beneficiaries 66 years of age or older, we identified patients diagnosed with atrial fibrillation and those diagnosed with atrial flutter. The primary outcome was ischemic stroke. Read More

    Atrial fibrillation decision support tool: Population perspective.
    Am Heart J 2017 Dec 23;194:49-60. Epub 2017 Aug 23.
    Department of Family and Community Medicine, University of Cincinnati, Cincinnati, OH.
    Background: Appropriate thromboprophylaxis for patients with atrial fibrillation or atrial flutter (AF) remains a national challenge. The recent availability of direct oral anticoagulants (DOACs) with comparable efficacy and improved safety compared with warfarin alters the balance between risk factors for stroke and benefit of anticoagulation. Our objective was to examine the impact of DOACs as an alternative to warfarin on the net benefit of oral anticoagulant therapy (OAT) in a real-world population of AF patients. Read More

    Usefulness of ultra-high resolution mapping for detecting epicardial atrial activation during mitral isthmus ablation.
    J Electrocardiol 2017 Nov 21. Epub 2017 Nov 21.
    Department of Arrhythmia, Ijinkai Takeda General Hospital, Japan. Electronic address:
    We describe a patient with perimitral atrial flutter (PMF) following the atrial fibrillation ablation and the linear ablation at the mitral isthmus (MI). From both the activation and the voltage maps using ultra-high resolution mapping, we detected the epicardial connection through the coronary sinus (CS) within the entire reentrant circuit. Point ablation within the CS, not additional linear MI ablation from the endocardium terminates PMF, with a bidirectional block across the low voltage area at the MI. Read More

    Significance of High-Sensitivity Troponin T After Elective External Direct Current Cardioversion for Atrial Fibrillation or Atrial Flutter.
    Am J Cardiol 2018 Jan 19;121(2):188-192. Epub 2017 Oct 19.
    Department of Cardiology, University Hospital Limerick, Ireland.
    External transthoracic direct current (DC) cardioversion is a commonly used method of terminating cardiac arrhythmias. Previous research has shown that DC cardioversion resulted in myocardial injury as evidenced by increased levels of cardiac troponin, even though only minimally. Many of these studies were based on the outdated monophasic defibrillators and older, less sensitive troponin assays. Read More

    Impact of Cardiorespiratory Fitness on Frequency of Atrial Fibrillation, Stroke, and All-Cause Mortality.
    Am J Cardiol 2018 Jan 13;121(1):41-49. Epub 2017 Nov 13.
    Mayo Clinic, Rochester, Minnesota. Electronic address:
    Benefits of cardiorespiratory fitness on cardiovascular health are well recognized, but the impact on incidence of atrial fibrillation (AF) and stroke, and, particularly, risk of stroke and mortality in patients with AF is less clear. From 1993 to 2010, patients referred for a treadmill exercise test (TMET) at the Mayo Clinic Rochester, MN, were retrospectively identified (N = 76,857). From this, 14,094 local residents were selected. Read More

    Effectiveness and safety of simultaneous hybrid thoracoscopic endocardial catheter ablation of atrial fibrillation in obese and non-obese patients.
    J Thorac Dis 2017 Sep;9(9):3087-3096
    Department of Cardiology, Maastricht University, Maastricht, the Netherlands.
    Background: We evaluated the safety and effectiveness of the hybrid thoracoscopic endocardial epicardial ablation technique for the treatment of atrial fibrillation (AF) in obese versus non-obese patients.

    Methods: Between January 2010 and January 2015, a cohort of 61 patients were retrospectively identified to undergo ablation of AF as a stand-alone procedure using a thoracoscopic, hybrid epicardial-endocardial technique. All patients underwent continuous 7-day Holter monitoring at 3, 6 months, 1 year and yearly thereafter. Read More

    Pharmacologic Prevention of Incident Atrial Fibrillation: Long-Term Results From the ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial).
    Circ Arrhythm Electrophysiol 2017 Dec;10(12)
    From the Knight Cardiovascular Institute, Oregon Health & Science University, Portland (T.A.D.); Cardiology Section, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.); University of Texas School of Public Health, Houston (J.-M.Y., B.R.D., L.M.S.); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (A.A.); Center for Arrhythmia Prevention, Division of Preventive Medicine and Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (C.M.A.); Keck School of Medicine, University of Southern California, Los Angeles (L.J.H.); and Electrophysiology Section, Division of Cardiology, Department of Medicine, University of California, San Francisco (G.M.M.).
    Background: Although atrial fibrillation (AF) guidelines indicate that pharmacological blockade of the renin-angiotensin system may be considered for primary AF prevention in hypertensive patients, previous studies have yielded conflicting results. We sought to determine whether randomization to lisinopril reduces incident AF or atrial flutter (AFL) compared with chlorthalidone in a large clinical trial cohort with extended post-trial surveillance.

    Methods And Results: We performed a secondary analysis of the ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial), a randomized, double-blind, active-controlled clinical trial that enrolled hypertensive individuals ≥55 years of age with at least one other cardiovascular risk factor. Read More

    Letermovir Prophylaxis for Cytomegalovirus in Hematopoietic-Cell Transplantation.
    N Engl J Med 2017 12 6;377(25):2433-2444. Epub 2017 Dec 6.
    From the Dana-Farber Cancer Institute and Brigham and Women's Hospital (F.M.M.) and Tufts Medical Center and Tufts University School of Medicine (D.R.S.), Boston; Karolinska University Hospital and Karolinska Institutet, Stockholm (P.L.); University of Texas M.D. Anderson Cancer Center, Houston (R.F.C.); Universitaire Ziekenhuizen Leuven, Leuven, Belgium (J.M.); City of Hope National Medical Center, Duarte (S.S.D.), and Stanford University School of Medicine, Palo Alto (J.B.) - both in California; Hospital Universitario Puerta de Hierro-Majadahonda, Madrid (R.F.D.); Juravinski Hospital and Cancer Center, McMaster University, Hamilton, ON, Canada (S.H.); Universitätsklinikum Würzburg, Würzburg, Germany (A.J.U., H.E.); Hiroshima Red Cross Hospital and Atomic-Bomb Survivors Hospital, Hiroshima (Y. Katayama), and Saitama Medical Center, Jichi Medical University, Saitama (Y. Kanda) - both in Japan; University of Chicago, Chicago (K.M.M.); Fred Hutchinson Cancer Research Center, Seattle (M.B.); Perelman School of Medicine at the University of Pennsylvania, Philadelphia (E.A.B.); and Merck, Kenilworth, NJ (M.J.D., V.L.T., H.W., Y.M., N.A.K., R.Y.L., C.B.).
    Background: Cytomegalovirus (CMV) infection remains a common complication after allogeneic hematopoietic-cell transplantation. Letermovir is an antiviral drug that inhibits the CMV-terminase complex.

    Methods: In this phase 3, double-blind trial, we randomly assigned CMV-seropositive transplant recipients, 18 years of age or older, in a 2:1 ratio to receive letermovir or placebo, administered orally or intravenously, through week 14 after transplantation; randomization was stratified according to trial site and CMV disease risk. Read More

    First clinical experience of a dedicated irrigated-tip radiofrequency ablation catheter for the ablation of cavotricuspid isthmus-dependent atrial flutter.
    Clin Res Cardiol 2017 Dec 4. Epub 2017 Dec 4.
    Cardiology/Electrophysiology, University Hospital Basel, University of Basel, Petersgraben 4, 4031, Basel, Switzerland.
    Background: Different types of irrigated-tip ablation catheters are available for ablation of atrial flutter (AFL). The aim of this study was to compare an established with a novel dedicated Gold irrigated-tip catheter for ablation of AFL.

    Methods And Results: We compared consecutive patients undergoing ablation of AFL using a standard 3. Read More

    Usefulness of Routine Transtelephonic Monitoring for Supraventricular Tachycardia in Infants.
    J Pediatr 2017 Nov 30. Epub 2017 Nov 30.
    Division of Pediatric Cardiology, Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, NY.
    Objective: We hypothesize that routine daily transtelephonic monitoring (TTM) transmissions can accurately detect supraventricular tachycardia (SVT) in asymptomatic infants and/or assuage parental concerns rather than being used solely to diagnose arrhythmias.

    Study Design: Single center, retrospective chart review of 60 patients with fetal or infant SVT prescribed TTM for at least 30 days, January 2010-September 2016. Patients were excluded if initial SVT was not documented, was perioperative, was atrial flutter/fibrillation, or chaotic atrial tachycardia. Read More

    Recurrence after pulmonary vein isolation is associated with low contact force.
    Scand Cardiovasc J 2018 Feb 30;52(1):28-33. Epub 2017 Nov 30.
    a Department of Cardiology , Aarhus University Hospital , Aarhus , Denmark.
    Objectives: Recurrent arrhythmia after pulmonary vein isolation (PVI) by radiofrequency (RF) ablation in patients with atrial fibrillation (AFIB) remains a significant challenge. Using contact force (CF) sensing ablation catheters, we aimed to identify procedure related parameters associated with recurrence after de-novo PVI in patients with AFIB.

    Methods: Consecutive patients undergoing a de-novo PVI procedure (n = 120, 63% paroxysmal and 37% persistent AFIB) employing a force-sensing ablation catheter were included. Read More

    Incidence of drug-induced torsades de pointes with intravenous amiodarone.
    Indian Heart J 2017 Nov - Dec;69(6):707-713. Epub 2017 Jun 3.
    Sri Jayadeva Institute Of Cardiovascular Sciences and Research, 9th Block Jayanagar, Bannerghatta Road, Bengaluru 560069, India.
    Aim: To define the incidence, presentation, and outcomes of drug-induced Torsades de Pointes (TdP) with intravenous (IV) amiodarone.

    Methods: From January 2014 to August 2016 a total of 268 patients received IV amiodarone, 142 for ventricular tachycardia, 104 for atrial flutter/fibrillation, and 22 for incessant atrial tachycardia. A uniform dosing of amiodarone to yield 1gm/day was used in all patients. Read More

    Pharmacokinetics of Magnesium Bolus Therapy in Cardiothoracic Surgery.
    J Cardiothorac Vasc Anesth 2017 Sep 1. Epub 2017 Sep 1.
    Department of Intensive Care, Austin Hospital, Heidelberg, Melbourne, Australia; University of Melbourne, Melbourne, Australia. Electronic address:
    Objective: To investigate the pharmacokinetics of a 20 mmol magnesium bolus in regards to serum and urinary magnesium concentration, volume of distribution, and half-life.

    Design: Prospective, experimental study.

    Setting: A university-affiliated teaching hospital. Read More

    [Clinical characteristics and outcome comparison between atrial fibrillation patients underwent catheter ablation under general aesthesia or local anesthesia and sedation].
    Zhonghua Xin Xue Guan Bing Za Zhi 2017 Nov;45(11):935-939
    First Affiliated Hospital of Dalian Medical University, Dalian 116000, China.
    Objective: To compare the outcome of radiofrequency catheter ablation under local anesthesia/sedation (S) or general anesthesia(GA) in atrial fibrillation patients. Methods: Data of 498 patients with atrial fibrillation undergoing radiofrequency catheter ablation in our departmentfrom January 2014 to December 2015 were retrospectively analyzed. Two hundred and twenty patients assigned to the GA group, the other 278 patients to the S group. Read More

    PLAAF score as a novel predictor of long-term outcome after second-generation cryoballoon pulmonary vein isolation.
    Europace 2017 Nov 16. Epub 2017 Nov 16.
    Department of Cardiology, Kerckhoff Heart Center, Benekestr. 2-8, 61231 Bad Nauheim, Germany.
    Aims: Predictors of atrial arrhythmia recurrence have not been described in a long-term follow-up study of patients undergoing pulmonary vein isolation (PVI) using the cryoballoon technique. We aimed to evaluate the efficacy of a second-generation cryoballoon and identify pre-procedural predictors of 3-year outcome after PVI.

    Methods And Results: For this observational cohort study, we enrolled 440 patients ablated at our institution with a second-generation cryoballoon. Read More

    Catheter ablation of typical atrial flutter with the superior approach in a patient with inferior vena cava interruption.
    Clin Case Rep 2017 Nov 26;5(11):1834-1836. Epub 2017 Sep 26.
    Department of Invasive CardiologyClinic of CardiologyAcibadem City ClinicTokuda HospitalSofiaBulgaria.
    Inferior vena cava (IVC) interruption is a rare condition that might pose difficulties during typical flutter ablation. When azygos vein continuation is present ablation via the femoral route could be performed. In the absence of azygos vein continuation, typical atrial flutter ablation via a superior approach from the SVC is feasible. Read More

    Risk profiles for acute health events after incident atrial fibrillation in patients with end-stage renal disease on hemodialysis.
    Nephrol Dial Transplant 2017 Nov 13. Epub 2017 Nov 13.
    Selzman Institute for Kidney Health, Section of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
    Background: Little is known about the cardiovascular risks of incident atrial fibrillation/flutter (AF) in patients with end-stage renal disease (ESRD) undergoing hemodialysis (HD).

    Methods: We studied older US patients who newly initiated HD for ESRD (2006-11) and who had not previously been diagnosed with AF, stroke, myocardial infarction (MI) or hip fracture. We used Cox regression with AF as a time-varying covariate, adjusted for socio-demographic characteristics and comorbidities to estimate hazard ratios [HRs (95% confidence intervals)] for the events of ischemic stroke, MI and death. Read More

    WITHDRAWN: Pharmacological cardioversion for atrial fibrillation and flutter.
    Cochrane Database Syst Rev 2017 11 15;11:CD003713. Epub 2017 Nov 15.
    Ward 11, Victoria Hospital, Hayfield Road, Kirkcaldy, UK, KY2 5AH.
    Background: Atrial fibrillation is the commonest cardiac dysrhythmia. It is associated with significant morbidity and mortality. There are two approaches to the management of atrial fibrillation: controlling the ventricular rate or converting to sinus rhythm in the expectation that this would abolish its adverse effects. Read More

    WITHDRAWN: Electrical cardioversion for atrial fibrillation and flutter.
    Cochrane Database Syst Rev 2017 11 15;11:CD002903. Epub 2017 Nov 15.
    Centre for Clinical Brain Sciences, University of Edinburgh, Room S1642, Royal Infirmary, Little France Crescent, Edinburgh, UK, EH16 4SA.
    Background: Atrial fibrillation increases stroke risk and adversely affects cardiovascular haemodynamics. Electrical cardioversion may, by restoring sinus rhythm, improve cardiovascular haemodynamics, reduce the risk of stroke, and obviate the need for long-term anticoagulation.

    Objectives: To assess the effects of electrical cardioversion of atrial fibrillation or flutter on the risk of thromboembolic events, strokes and mortality (primary outcomes), the rate of cognitive decline, quality of life, the use of anticoagulants and the risk of re-hospitalisation (secondary outcomes) in adults (>18 years). Read More

    Current status of cardiovascular surgery in Japan, 2013 and 2014: A report based on the Japan Cardiovascular Surgery Database. 4. Valvular heart surgery.
    Gen Thorac Cardiovasc Surg 2018 Jan 13;66(1):13-18. Epub 2017 Nov 13.
    Japan Cardiovascular Surgery Database, Tokyo, Japan.
    Data from the Japan cardiovascular surgery database from 2013 to 2014 were analyzed to demonstrate the mortality rate and choice of surgical procedures, especially concerning the selection of valve prosthesis for each valve position and patient age group, and the effects of preoperative complications on mortality and prosthetic valve selection. The proportion of each surgical procedure was compared for each patient age in the aortic, mitral, and tricuspid positions. The proportion of mechanical valve prostheses was 23. Read More

    Right Atrial Fibroelastoma Presenting as Typical Atrial Flutter: Rare Disease in Unusual Location.
    Case Rep Cardiol 2017 10;2017:4764587. Epub 2017 Oct 10.
    Department of Cardiology, Saint Joseph's Regional Medical Center, 703 Main St, Paterson, NJ 07503, USA.
    Typical atrial flutter as initial presentation of papillary fibroelastoma involving the cavotricuspid isthmus is not described before in literature. To our knowledge only 14 cases have been reported in literature involving the right atrium. Very unusual location is at the junction between inferior vena cava (IVC) and right atria as only 1 case has been reported. Read More

    Preoperative Use of Oral Beta-Adrenergic Blocking Agents and the Incidence of New-Onset Atrial Fibrillation After Cardiac Surgery. A Systematic Review and Meta-Analysis.
    Heart Lung Circ 2017 Oct 19. Epub 2017 Oct 19.
    MonashHeart, Monash Cardiovascular Research Centre, Monash Health & Department of Medicine (MMC), Monash University, Melbourne, Vic, Australia.
    Background: Current epidemiological data suggests that postoperative atrial fibrillation or atrial flutter (POAF) causes significant morbidity and mortality after cardiac surgery. The literature for prophylactic management of POAF is limited, resulting in the lack of clear guidelines on management recommendations.

    Aim: To examine the efficacy of prophylactic rate control agents in reducing the incidence of new-onset POAF in patients undergoing elective cardiac surgery. Read More

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