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    Cardiovascular outcomes for patients with symptomatic peripheral artery disease: A cohort study in The Health Improvement Network (THIN) in the UK.
    Eur J Prev Cardiol 2017 Jan 1:2047487317736824. Epub 2017 Jan 1.
    1 Pharmacoepidemiology, Spanish Centre for Pharmacoepidemiologic Research (CEIFE), Spain.
    Background Few data are available on risk factors and associations with outcomes in symptomatic peripheral artery disease (PAD) populations in primary care. We assessed characteristics and cardiovascular outcomes in patients with and those without symptomatic peripheral artery disease in UK primary care, and quantified risk factors for cardiovascular outcomes in patients with peripheral artery disease. Methods Among patients in The Health Improvement Network (THIN) aged 50-89 years in 2000-2010, a symptomatic peripheral artery disease cohort ( n = 28,484) and a matched comparison cohort without peripheral artery disease ( n = 113,940) were identified using Read codes. Read More

    High overall cardiovascular risk and mortality in patients with atrial fibrillation and diabetes: A nationwide report.
    Diab Vasc Dis Res 2017 Oct 1:1479164117735013. Epub 2017 Oct 1.
    4 Cardiology Unit, Department of Medicine K2, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
    Aim: To describe nationwide complication patterns in patients with atrial fibrillation and diabetes mellitus.

    Methods: All ( n = 326,832) patients in Sweden with non-valvular atrial fibrillation during 2006-2012 were identified, and information on events, comorbidities and pharmacological therapy was extracted using nationwide mandatory registers. Patients were followed until 31 December 2013 and the mean follow-up time was 3. Read More

    Patients' knowledge on oral anticoagulant treatment in Hungary.
    Int J Clin Pharm 2017 Oct 19. Epub 2017 Oct 19.
    Department of Pharmaceutical Technology and Drug Regulatory Affairs, University of Szeged, Szeged, Hungary.
    Background A key element for an effective and safe oral anticoagulant treatment (OAT) is to have the relevant information delivered to patients in an easy-to-understand way and thus have them apply this knowledge in their own therapy. Objective To assess knowledge about OAT, reveal knowledge gaps and identify at-risk patients in terms of limited knowledge about their anticoagulant therapy. Setting Community pharmacies in Hungary. Read More

    Anticoagulation prescribing patterns in patients with cancer.
    J Thromb Thrombolysis 2017 Oct 19. Epub 2017 Oct 19.
    Department of Pharmacy, Director of Clinical Pharmacy Services, NYU Langone Health, 550 First Avenue, New York, NY, 10016, USA.
    Cancer is a known hypercoagulable state that leads to an increased risk of venous thromboembolism (VTE). Low molecular weight heparin remains the preferred anticoagulant for VTE in patients with cancer over vitamin K antagonist. However, the preferred anticoagulant in prevention of stroke and systemic embolism in atrial fibrillation (AF) in patients with cancer has yet to be determined. Read More

    Reduced Myocardial Flow Reserve is Associated with Diastolic Dysfunction and Decreased Left Atrial Strain in Patients with Normal Ejection Fraction and Epicardial Perfusion.
    J Card Fail 2017 Oct 16. Epub 2017 Oct 16.
    Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI; Ann Arbor Veterans Affairs Health System, Ann Arbor, MI.
    Introduction: Coronary microvascular dysfunction (MVD) may contribute to the pathogenesis of heart failure with preserved ejection fraction (HFpEF). Speckle-tracking echocardiography is a feasible and reproducible method for identifying abnormalities in left ventricular (LV) and left atrial (LA) function among HFpEF patients. By assessing myocardial flow reserve (MFR), positron emission tomography (PET) imaging enables quantitative assessment of coronary MVD. Read More

    The impact of supraventricular ectopic complexes in different age groups and risk of recurrent atrial fibrillation after antiarrhythmic medication or catheter ablation.
    Int J Cardiol 2017 Oct 9. Epub 2017 Oct 9.
    Rigshospitalet, Copenhagen, Denmark.
    Introduction: Supraventricular ectopic complexes (SVEC) are known risk factors of recurrent atrial fibrillation (AF). However, the impact of SVEC in different age groups is unknown. We aimed to investigate the risk of AF recurrence with higher SVEC burden in patients ±57years, respectively, after treatment with antiarrhythmic medication (AAD) or catheter ablation (CA). Read More

    Homocysteine in non-valvular atrial fibrillation: Role and clinical implications.
    Clin Chim Acta 2017 Oct 16;475:85-90. Epub 2017 Oct 16.
    Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, PR China.
    Atrial fibrillation (AF), the most common sustained arrhythmia, is associated with a series of adverse complications that cause so-called AF socioeconomic burden. Apart from the classical risk factors, it seems to be novel factors that increase the risk of AF and AF-related stroke. Recently, more and more evidence has well documented the close relationships between homocysteine (Hcy) and AF. Read More

    [Diagnosis of arrhythmias on memories of pacemakers and defibrillators: Practical management].
    Ann Cardiol Angeiol (Paris) 2017 Oct 16. Epub 2017 Oct 16.
    Unité de rythmologie, GHI Le Raincy-Montfermeil, 10, rue du Gl-Leclerc, 93370 Montfermeil, France. Electronic address:
    Pacemakers and defibrillators have holter capabilities that can record episodes of arrhythmias. Different studies evaluated the effect on the risk of strokes of different durations of arrhythmias. The question of the management of patients depending on the duration of the arrhythmia episode is addressed in this article depending on the duration of the episode and the arrhythmia burden. Read More

    A Missense Variant in PLEC Increases Risk of Atrial Fibrillation.
    J Am Coll Cardiol 2017 Oct;70(17):2157-2168
    deCODE genetics/Amgen, Inc., Reykjavik, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland. Electronic address:
    Background: Genome-wide association studies (GWAS) have yielded variants at >30 loci that associate with atrial fibrillation (AF), including rare coding mutations in the sarcomere genes MYH6 and MYL4.

    Objectives: The aim of this study was to search for novel AF associations and in doing so gain insights into the mechanisms whereby variants affect AF risk, using electrocardiogram (ECG) measurements.

    Methods: The authors performed a GWAS of 14,255 AF cases and 374,939 controls, using whole-genome sequence data from the Icelandic population, and tested novel signals in 2,002 non-Icelandic cases and 12,324 controls. Read More

    First Evidence: TRAP-Induced Platelet Aggregation Is Reduced in Patients Receiving Xabans.
    Clin Appl Thromb Hemost 2017 Jan 1:1076029617734310. Epub 2017 Jan 1.
    1 First Department of Internal Medicine, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia.
    The availability of direct oral anticoagulants has caused a paradigm shift in the management of thrombosis. Rivaroxaban and apixaban are 2 direct oral anticoagulants whose target specificity is activated factor X (FXa). However, it is still not fully understood if and how xabans impact platelet function. Read More

    Comparison of CHA2DS2-VASc, CHADS2 and HATCH scores for the prediction of new-onset atrial fibrillation in cancer patients: A nationwide cohort study of 760,339 study participants with competing risk analysis.
    Atherosclerosis 2017 Oct 7;266:205-211. Epub 2017 Oct 7.
    Management Office for Health Data, China Medical University Hospital, Taichung 40447, Taiwan.
    Background And Aims: The current study was conducted to assess the ability of CHA2DS2-VASc, CHADS2 and HATCH scores in predicting new-onset atrial fibrillation (AF) among patients with cancer.

    Methods: Patients with newly diagnosed cancer between 1 January, 2000 and 31 December, 2011, from the Registry for Catastrophic Illness Patient Database, were defined as the study cohort. CHA2DS2-VASc, CHADS2 and HATCH scores were used for new-onset AF prediction in these study patients, and the predictive accuracy of the scores was assessed by the receiver operating characteristics (ROC) curve. Read More

    Preoperative statins as modifiers of cardiac and inflammatory outcomes following coronary artery bypass graft surgery: a meta-analysis.
    Interact Cardiovasc Thorac Surg 2017 Jul 26. Epub 2017 Jul 26.
    Department of Cardiac Surgery, Second Hospital of Hebei Medical University, Shi Jiazhuang, China.
    Early postoperative cardiac complications of coronary artery bypass graft surgery, such as atrial fibrillation (AF) or myocardial infarction (MI), may be beneficially modulated by preoperative statins, involving their anti-inflammatory effects. There is uncertainty on the clinical merit of statin pretreatment. Addressing this, we conducted a meta-analysis of early cardiac complications and inflammatory markers following statin pretreatment in coronary artery bypass graft surgery. Read More

    Extended pleurectomy decortication for malignant pleural mesothelioma in the elderly: the need for an inclusive yet selective approach.
    Interact Cardiovasc Thorac Surg 2017 Jul 21. Epub 2017 Jul 21.
    Department of Thoracic Surgery, University Hospitals Leicester, Leicester, UK.
    Objectives: The median age at diagnosis of patients with pleural mesothelioma in the UK is 73 years. Recent series have shown the feasibility of extended pleurectomy decortication in the elderly, but with continuing debate about the efficacy of this treatment, we reviewed our experience to identify more detailed selection criteria.

    Methods: We reviewed prospectively collected data on all patients from 1999 to 2016 undergoing extended pleurectomy decortication. Read More

    Hybrid treatment combining robotic coronary artery bypass grafting and percutaneous catheter radiofrequency ablation.
    Interact Cardiovasc Thorac Surg 2017 Aug 31. Epub 2017 Aug 31.
    Department of Cardiovascular Surgery, NewHeart Watanabe Institute, Suginami, Tokyo, Japan.
    Isolated coronary artery bypass grafting associated with atrial fibrillation is routinely performed through a sternotomy, and cardiac arrest. Advancements in this surgical approach have led to better cosmesis, a quick postoperative recovery, with the same postoperative results. We report a case of a novel, less invasive hybrid treatment combining robot-assisted coronary artery bypass grafting and percutaneous radiofrequency catheter ablation. Read More

    Two-staged hybrid ablation of non-paroxysmal atrial fibrillation: clinical outcomes and functional improvements after 1 year.
    Interact Cardiovasc Thorac Surg 2017 Jul 31. Epub 2017 Jul 31.
    Cardiocenter, Department of Cardiac Surgery, Third Faculty of Medicine, Charles University, Prague and University Hospital Kralovske Vinohrady, Prague, Czech Republic.
    Objectives: Hybrid ablation of atrial fibrillation (AF) is a promising treatment strategy; however, data regarding its efficacy and safety are still limited.

    Methods: Patients with non-paroxysmal AF were enrolled. First, a thoracoscopic, epicardial isolation of pulmonary veins and the left atrial posterior wall ('box lesion') was performed; a novel unipolar/bipolar radiofrequency device was used. Read More

    Endothelin-1 is associated with dilatation of the left atrium and can be an independent predictor of atrial fibrillation after mitral valve surgery.
    Interact Cardiovasc Thorac Surg 2017 Aug 14. Epub 2017 Aug 14.
    Department of Cardiothoracic Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
    Objectives: This study analysed the association between endothelin-1 (ET-1) and left atrial dimension (LAD) and evaluated whether ET-1 can be a predictor of postoperative atrial fibrillation (POAF) after mitral valve surgery.

    Methods: This is a prospective study that enrolled 80 patients who underwent isolated mitral valve surgery. Plasma concentrations of ET-1 from peripheral venous blood were tested. Read More

    Feasibility, Process, and Outcomes of Cardiovascular Clinical Trial Data Sharing: A Reproduction Analysis of the SMART-AF Trial.
    JAMA Cardiol 2017 Oct 18. Epub 2017 Oct 18.
    Department of Medicine, Northwestern University, Chicago, Illinois.
    Importance: Data sharing is as an expanding initiative for enhancing trust in the clinical research enterprise.

    Objective: To evaluate the feasibility, process, and outcomes of a reproduction analysis of the THERMOCOOL SMARTTOUCH Catheter for the Treatment of Symptomatic Paroxysmal Atrial Fibrillation (SMART-AF) trial using shared clinical trial data.

    Design, Setting, And Participants: A reproduction analysis of the SMART-AF trial was performed using the data sets, data dictionary, case report file, and statistical analysis plan from the original trial accessed through the Yale Open Data Access Project using the SAS Clinical Trials Data Transparency platform. Read More

    Postoperative Outcomes in Obstructive Sleep Apnea Patients Undergoing Cardiac Surgery: A Systematic Review and Meta-Analysis of Comparative Studies.
    Anesth Analg 2017 Oct 17. Epub 2017 Oct 17.
    From the *Department of Anesthesia and Perioperative Medicine, London Health Sciences Centre and St Joseph Health Care, Western University, London, Ontario, Canada; †Department of Anesthesiology and Pain Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada; Departments of ‡Hospital Medicine and §Outcomes Research (Anesthesiology), Cleveland Clinic, Cleveland, Ohio; ‖Centre for Medical Evidence, Decision Integrity and Clinical Impact (MEDICI), Western University, London, ON, Canada; and ¶Department of Anesthesia & Perioperative Medicine, Western University, London, ON, Canada.
    Background: Obstructive sleep apnea (OSA) is a common comorbidity in patients undergoing cardiac surgery and may predispose patients to postoperative complications. The purpose of this meta-analysis is to determine the evidence of postoperative complications associated with OSA patients undergoing cardiac surgery.

    Methods: A literature search of Cochrane Database of Systematic Reviews, Medline, Medline In-process, Web of Science, Scopus, EMBASE, Cochrane Central Register of Controlled Trials, and CINAHL until October 2016 was performed. Read More

    Atrial fibrillation occurring transiently with stress.
    Curr Opin Cardiol 2017 Oct 18. Epub 2017 Oct 18.
    Population Health Research Institute and McMaster University, Hamilton, Ontario, Canada.
    Purpose Of Review: Atrial fibrillation may be detected in the setting of an acute stressor, such as medical illness or surgery. It is uncertain if atrial fibrillation detected in these settings (AFOTS: atrial fibrillation occurring transiently with stress) is secondary to a reversible trigger or is simply paroxysmal atrial fibrillation. This distinction is critical for clinicians, who must decide if AFOTS can be dismissed as a reversible phenomenon, or if it signals the need for chronic therapy; in particular, anticoagulation. Read More

    The impact of lifestyle intervention on atrial fibrillation.
    Curr Opin Cardiol 2017 Oct 18. Epub 2017 Oct 18.
    Department of Cardiology, Queen's University, Kingston, Ontario, Canada.
    Purpose Of Review: Atrial fibrillation is the most common sustained cardiac arrhythmia, attributable to several factors that may be amenable through lifestyle modification. There is emerging evidence to suggest that the successful management of several cardiovascular risk factors [obesity, hypertension (HTN), diabetes mellitus, and obstructive sleep apnea (OSA)] can lead to fewer complications and atrial fibrillation prevention. However, the long-term sustainability and reproducibility of these effects have yet to be explored in larger studies. Read More

    Effectiveness and patient safety of platelet aggregation inhibitors in the prevention of cardiovascular disease and ischemic stroke in older adults - a systematic review.
    BMC Geriatr 2017 Oct 16;17(Suppl 1):225. Epub 2017 Oct 16.
    Institute of General Practice and Family Medicine, Faculty of Health, University of Witten/Herdecke, Alfred-Herrhausen-Straße, Witten, Germany.
    Background: Platelet aggregation inhibitors (PAI) are among the most frequently prescribed drugs in older people, though evidence about risks and benefits of their use in older adults is scarce. The objectives of this systematic review are firstly to identify the risks and benefits of their use in the prevention and treatment of vascular events in older adults, and secondly to develop recommendations on discontinuing PAI in this population if risks outweigh benefits.

    Methods: Staged systematic review consisting of three searches. Read More

    Real-world comparison of all-cause hospitalizations, hospitalizations due to stroke and major bleeding, and costs for nonvalvular atrial fibrillation patients prescribed oral anticoagulants in a US health plan.
    J Med Econ 2017 Oct 19:1-24. Epub 2017 Oct 19.
    d Pfizer Inc. , 235 East 42nd Street , New York , NY , USA.
    Aims: Compare the risk of all-cause hospitalization and hospitalizations due to stroke/systemic embolism (SE) and major bleeding as well as associated health care costs for nonvalvular atrial fibrillation (NVAF) patients initiating apixaban, dabigatran, rivaroxaban, or warfarin.

    Materials And Methods: NVAF patients initiating apixaban, dabigatran, rivaroxaban, or warfarin were selected from the OptumInsight Research Database from 01JAN2013-30SEP2015. Propensity score matching (PSM) was performed between apixaban and each oral anticoagulant. Read More

    Simultaneous Closure of a Left Atrial Appendage through an Atrial Septal Defect and the Atrial Septal Defect.
    Yonsei Med J 2017 Nov;58(6):1237-1240
    Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, Korea.
    Left atrial appendage (LAA) occlusion can be employed as an alternative treatment to oral anticoagulation in patients with atrial fibrillation to prevent embolic events. Atrial septal defect (ASD) may be related with right heart dysfunction and allow paradoxical embolism to occur. However, occlusion of both LAA through atrial access with ostium secundum ASD and ASD in the same setting is unusual. Read More

    Gender Difference in the Long-Term Clinical Implications of New-Onset Atrial Fibrillation after Coronary Artery Bypass Grafting.
    Yonsei Med J 2017 Nov;58(6):1119-1127
    Division of Cardiology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
    Purpose: New-onset postoperative atrial fibrillation (POAF) is associated with poor short- and long-term outcomes after isolated coronary artery bypass graft (CABG) surgery. This study evaluated gender differences in the long-term clinical implications of POAF.

    Materials And Methods: After propensity score matching, a gender-based comparison of long-term (>1 year) newly developed atrial fibrillation (LTAF) and mortality between 1664 (480 females) consecutive patients with (POAF) and without POAF (no-POAF) who had undergone CABG was performed. Read More

    Colchicine: A Review About Chemical Structure and Clinical Using.
    Infect Disord Drug Targets 2017 Oct 17. Epub 2017 Oct 17.
    Dept. chemistry, Faculty of Science, Damascus University Syria. Syrian Arab Republic.
    For many years, colchicine has been used for therapeutic purposes and has been given considerable attention because of its association with tubulin and inhibition of small tubular polymerization. Colchicine is an alkaloids extracted from the colchicum autumnale plant, and it contains a molecular formula C22H25NO6, and it consists of three rings. Many studies have concerned with structural changes, in order to increase their pharmacological effectiveness and to reduce the side effects of toxicity arising from it. Read More

    Crossing the bridge to VATS lobectomy.
    Ann R Coll Surg Engl 2017 Oct 19:1-3. Epub 2017 Oct 19.
    Leeds Teaching Hospitals NHS Trust , UK.
    Introduction The impact of the introduction of video assisted thoracoscopic surgery (VATS) on the management of lung cancer 20 years ago has been well documented. However, the uptake of VATS lobectomy in surgical practice worldwide has been slower than expected. We believe that this is partly due to a lack of consensus on how this procedure should be integrated into training programmes. Read More

    CTS trials network: Rate control vs rhythm control for atrial fibrillation after cardiac surgery - Do bitter pills have blessed effects?
    Glob Cardiol Sci Pract 2016 Jun 30;2016(2):e201615. Epub 2016 Jun 30.
    Aswan Heart Center, Aswan, Egypt.
    New onset AF is a very common sequel of cardiac surgery with an incidence reaching 50% in some studies. This post-operative complication leads to increased morbidity, hospital stay and, consequently, hospital costs(1). Currently there is a great variability in the management of this condition. Read More

    Use of hemodialysis for the treatment of intracerebral hemorrhage in patients on dabigatran with normal renal function.
    Clin Nephrol Case Stud 2014 20;2:18-22. Epub 2014 Aug 20.
    Renal-Electrolyte Division University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
    Dabigatran is a direct thrombin inhibitor which is approved by the Food and Drug Administration (FDA) for prevention of embolic stroke in patients with atrial fibrillation. Dabigatran has been shown to be non- inferior to warfarin in preventing stroke in patients with atrial fibrillation [1, 6]. The rate of major bleeding in patients taking dabigatran is also similar to that seen in patients on warfarin [1]. Read More

    Thromboembolism in renal transplant artery due to atrial fibrillation.
    Clin Nephrol Case Stud 2013 28;1:10-13. Epub 2013 Oct 28.
    Division of Nephrology and Hypertension, Department of Medicine, Hannover Medical School, Hannover, Germany.
    Background: Central and peripheral arterial thromboembolisms are well known complications of atrial fibrillation. We report the first case of thromboembolism in a renal transplant due to atrial fibrillation after changing anticoagulation treatment.

    Case Presentation: A 79-year-old woman who had undergone kidney transplantation in 2001 presented herself with abdominal pain and oliguria. Read More

    Acute administration of tumour necrosis factor-α induces spontaneous calcium release via the reactive oxygen species pathway in atrial myocytes.
    Europace 2017 Oct 17. Epub 2017 Oct 17.
    Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Center for Cardiovascular Diseases, No. 2 Anzhen Road, Chaoyang District, Beijing 100029, China.
    Aims: The arrhythmogenic mechanisms of atrial fibrillation (AF) that are induced by acute inflammation, such as postoperative AF, are not well understood. We investigated the acute effects of tumour necrosis factor-α (TNF-α) that mimic acute inflammation on Ca2+ handling in isolated atrial myocytes and its underlying mechanisms.

    Methods And Results: Cytosol Ca2+ handling and mitochondrial reactive oxygen species (ROS) production were studied in freshly isolated atrial myocytes of wild-type mice that were exposed to TNF-α (0. Read More

    Past alcohol consumption and incident atrial fibrillation: The Atherosclerosis Risk in Communities (ARIC) Study.
    PLoS One 2017 18;12(10):e0185228. Epub 2017 Oct 18.
    Cardiac Electrophysiology Section, Division of Cardiology, Department of Medicine, University of California, San Francisco, San Francisco, CA, United States of America.
    Background: Although current alcohol consumption is a risk factor for incident atrial fibrillation (AF), the more clinically relevant question may be whether alcohol cessation is associated with a reduced risk.

    Methods And Results: We studied participants enrolled in the Atherosclerosis Risk in Communities Study (ARIC) between 1987 and 1989 without prevalent AF. Past and current alcohol consumption were ascertained at baseline and at 3 subsequent visits. Read More

    Atrial fibrillation and cardiac resynchronization therapy.
    Curr Opin Cardiol 2017 Oct 17. Epub 2017 Oct 17.
    Electrophysiology and Pacing Unit, Humanitas Research Hospital, Rozzano, Milano, Italy.
    Purpose Of Review: Atrial fibrillation and heart failure are commonly encountered in current clinical practice. This review aims to revisit the complex interaction of these two common situations and the best treatment whenever both occurs, especially focusing on heart failure patients undergoing cardiac resynchronization therapy (CRT).

    Recent Findings: It has been recently confirmed that in patients undergoing cardiac resynchronization therapy, 100% biventricular pacing percentage should be pursued. Read More

    Risk of stroke after transcatheter prosthetic aortic valve implant with aortic bioprosthesis: subclinical thrombosis and possible therapeutic implications.
    J Cardiovasc Med (Hagerstown) 2017 Oct 16. Epub 2017 Oct 16.
    Division of Cardiology, Maggiore Hospital, Bologna, Italy.
    : Many factors could increase the risk of stroke after transcatheter prosthetic aortic valve implant, mainly related to the procedure itself, or to the type of valvular prosthesis, or to the presence of atrial fibrillation. There is a wide variability in the antithrombotic treatment utilized in clinical practice, as far as the choice of drugs (anticoagulant, single or dual antiplatelet treatment), and its optimal duration. The most popular therapeutic strategy, also recommended by the Scientific Societies, is dual antiplatelet (aspirin and clopidogrel) for the first 3-6 months then switching to single antiplatelet (usually aspirin), limiting oral anticoagulant therapy only to those patients with other primary indication to the treatment. Read More

    The Prognostic Implications of Two-Dimensional Speckle Tracking Echocardiography in Hypertrophic Cardiomyopathy: Current and Future Perspectives.
    Cardiol Rev 2017 Oct 17. Epub 2017 Oct 17.
    From the 1st Cardiology department, AHEPA University Hospital, Thessaloniki, Greece.
    Two-dimensional (2D) speckle tracking echocardiography represents a novel, simple and reproducible technique for the estimation of left ventricular myocardial deformation (strain) and the evaluation of left ventricular twist mechanics. During the last few years, its clinical and prognostic implications in cardiomyopathies and hypertrophic cardiomyopathy (HCM) in particular have been rapidly increasing. Reduced global longitudinal strain is associated with more severe disease and confers an increased risk for major cardiac events, independently of other clinical and echocardiographic risk factors. Read More

    Comparison of Bleeding Risk Scores in Patients with Atrial Fibrillation:Insights from the RE-LY Trial.
    J Intern Med 2017 Oct 16. Epub 2017 Oct 16.
    Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden.
    Background: Oral anticoagulation is the mainstay of stroke prevention in atrial fibrillation (AF), but must be balanced against the associated bleeding risk. Several risk scores have been proposed for prediction of bleeding events in patients with AF.

    Objectives: To compare the performance of contemporary clinical bleeding risk scores in 18,113 patients with AF randomized to dabigatran 110 mg, 150 mg or warfarin in the RE-LY trial. Read More

    [Focused update on dual antiplatelet treatment : ESC guidelines 2017].
    Herz 2017 Oct 17. Epub 2017 Oct 17.
    Klinik für Kardiologie und Angiologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30659, Hannover, Deutschland.
    Dual antiplatelet treatment (DAPT) is a cornerstone of maintenance medication of patients following elective percutaneous coronary interventions or an acute coronary syndrome (ACS), e. g. ST elevation myocardial infarction, non-ST elevation myocardial infarction and unstable angina. Read More

    FIRE AND ICE: The quest for the perfect modality in atrial fibrillation ablation.
    Glob Cardiol Sci Pract 2016 Sep 30;2016(3):e201623. Epub 2016 Sep 30.
    Department of Cardiology, Aswan Heart Centre, Aswan, Egypt.
    Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. Catheter ablation of atrial fibrillation plays an important role in the management of AF. Radiofrequency ablation is widely used in practice all over the world. Read More

    Calciphylaxis in a nondialysis patient treated with sodium thiosulfate and high dose of oxygen.
    Clin Nephrol Case Stud 2017 6;5:38-41. Epub 2017 Jul 6.
    Department of Internal Medicine, Bassett Medical Center and Columbia University College of Physicians and Surgeons, Cooperstown, NY, USA, and.
    Background: Calciphylaxis in a nondialysis patient is a rare condition and is characterized by calcific deposition in tissue. We present a case of calciphylaxis in a nondialysis patient who was diagnosed by clinical presentation and skin biopsy and was treated with sodium thiosulfate with improvement of skin lesions.

    Case: A 43-year-old female with type 2 diabetes and atrial fibrillation taking oral anticoagulation medication presented with reddish drainage from the right buttock. Read More

    Recent advances in rhythm control for atrial fibrillation.
    F1000Res 2017 3;6:1796. Epub 2017 Oct 3.
    University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
    Atrial fibrillation (AF) remains a difficult management problem. The restoration and maintenance of sinus rhythm-rhythm control therapy-can markedly improve symptoms and haemodynamics for patients who have paroxysmal or persistent AF, but some patients fare well with rate control alone. Sinus rhythm can be achieved with anti-arrhythmic drugs or electrical cardioversion, but the maintenance of sinus rhythm without recurrence is more challenging. Read More

    Impaired Cardiac Autonomic Regulation and Long-Term Risk of Atrial Fibrillation in Patients With Coronary Artery Disease.
    Heart Rhythm 2017 Oct 14. Epub 2017 Oct 14.
    Research Unit of Internal Medicine, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland. Electronic address:
    Background: The influence of autonomic cardiac regulation on long-term risk of new-onset atrial fibrillation (AF) in coronary artery disease (CAD) is not well established.

    Objective: To evaluate the value of heart rate variability (HRV), a marker of cardiac autonomic regulation, in predicting new-onset AF in CAD.

    Methods: The Innovation to Reduce Cardiovascular Complications of Diabetes at the Intersection (ARTEMIS) study population consisted of 1,946 patients with CAD. Read More

    [Actual Issues of Choosing Anticoagulant Therapy for Long-term Prophylaxis of Thromboembolic Complications].
    Kardiologiia 2017 Aug;57(8):71-79
    State Budgetary Educational Institution "Samara State Medical University" of the RF Ministry of Health Care.
    The article contains presentation of actual problems of selection of anticoagulant therapy for long term prevention of thromboembolic complications in outpatients with atrial fibrillation, chronic heart failure, and chronic kidney disease.tions in ambulatory Patients with atrial fibrillation, chronic heart failure and chronic kidney disease. Read More

    [Review of Novel Clinical Recommendations on Diagnosis and Treatment of Atrial Fibrillation (2016) of the European Society of Cardiology Developed in Collaboration With the European Association for Car dio-Thor acic Surgery].
    Kardiologiia 2017 Jul;57(7):90-96
    Federal State Budgetary Educational Institution of Higher Education "I. M. Sechenov First Moscow State Medical University" of the Ministry of Health of the Russian Federation.

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