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    Isolated Right Ventricular Apical Trabecular Hypoplasia: A Case Report.
    J Heart Valve Dis 2017 Jan;26(1):107-110
    Department of Cardiac Surgery, Shandong Provincial Hospital, Affiliated Hospital of Shandong University, Jinan, China. Electronic correspondence:
    Right ventricular (RV) hypoplasia with isolated myocardial disease and complete absence of RV trabeculae is a rare congenital heart disease, the current treatment of which is ineffective. Here, a rare case is presented of a middle-aged female patient with RV hypoplasia complicated by tricuspid regurgitation, right atrial thrombus, and atrial fibrillation. The patient was treated with a one-and-a-half ventricular repair, and showed significant improvements in cardiac function and physical activity tolerance. Read More

    Analysis of adults with congenital heart disease presenting to pediatric emergency departments with arrhythmias.
    Congenit Heart Dis 2017 May 22. Epub 2017 May 22.
    Section of Cardiology, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas, USA.
    Objective: As survivors of congenital heart disease (CHD) continue to age, healthcare utilization by this population has increased. It is unknown how often these patients utilize the emergency department (ED) at children's hospitals and how arrhythmias play a role in their utilization of care.

    Design: Using a retrospective cohort design, the Pediatric Hospital Information System (PHIS) database was investigated and we studied adults (≥18 years) with CHD (ACHD) who presented to pediatric EDs from 2004 to 2014. Read More

    Thromboembolic and bleeding complications during oral anticoagulation therapy in cancer patients with atrial fibrillation: a Danish nationwide population-based cohort study.
    Cancer Med 2017 May 19. Epub 2017 May 19.
    Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
    Coexisting cancer in patients with atrial fibrillation (AF) has been associated with thromboembolism and bleeding. We used Danish population-based medical databases to conduct a population-based cohort study that included all AF patients who redeemed a prescription for vitamin K antagonists (VKA) or non-VKA oral anticoagulant (NOAC) between July 2004 and December 2013. We characterized these patients according to the presence (N = 11,855) or absence (N = 56,264) of a cancer diagnosis before redemption of their oral anticoagulant prescription, and then examined their 1-year risk of thromboembolic or bleeding complications or death. Read More

    Assessment of clinically relevant bleeding as a surrogate outcome for major bleeding: validation by meta-analysis of randomized controlled trials.
    J Thromb Haemost 2017 May 20. Epub 2017 May 20.
    SAINBIOSE U1059, Université Jean Monnet, Univ Lyon, INSERM, F-42023 Saint-Etienne; Unité de Recherche Clinique, Innovation, Pharmacologie, and Service de Médecine Vasculaire et Thérapeutique, CHU Saint-Etienne, Hôpital Nord, F-40255, Saint-Etienne, France.
    Background: Clinically relevant bleeding (CRB), comprising major bleeding and clinically relevant non-major bleeding, has been used as a surrogate for major bleeding in most anticoagulant trials, but its validity for estimating compromise between thrombotic and bleeding events has never been assessed.

    Methods: We systematically reviewed randomized phase III trials comparing new anticoagulants with standard of care for venous thromboembolism prevention following major orthopedic surgery, venous thromboembolism (VTE) treatment, or stroke and systemic embolism prevention in atrial fibrillation (AF), and reporting both major bleeding and CRB rates. The validity of CRB as a surrogate for major bleeding was assessed through the strength of the association between the relative risk (RR) of major bleeding and CRB, respectively, measured by R(2)trial and its 95% confidence interval (CI). Read More

    Antithrombotic therapy in end-stage renal disease.
    Hemodial Int 2017 May 23. Epub 2017 May 23.
    Division of Nephrology, Salisbury VA Health Care System (SVAHCS), Salisbury, North Carolina, USA.
    The delicate balance of risk vs. benefit of using antiplatelet and antithrombotic agents in the general population is well established. The decision to use these agents in the end stage renal disease (ESRD) population remains complex and difficult. Read More

    Clinical features of extremely elderly patients with heart failure.
    Geriatr Gerontol Int 2017 May 21. Epub 2017 May 21.
    Department of Cardiovascular Medicine, Fukushima Medical University, Fukushima City, Fukushima, Japan.
    Aim: To investigate the clinical features of heart failure in extremely elderly patients.

    Methods: We analyzed 1163 consecutive hospitalized heart failure patients. The patients were divided into an extremely elderly group (≥85 years-of-age, n = 88) and a non-extremely elderly group (<85 years-of-age, n = 1075). Read More

    Permanent nonselective His bundle pacing in an adult with L-transposition of the great arteries and complete AV block.
    Pacing Clin Electrophysiol 2017 May 24. Epub 2017 May 24.
    Indiana University, Director, Atrial Fibrillation Program, Krannert Institute of Cardiology, Indiana University Health Physicians.
    We report the placement of a permanent transvenous nonselective His bundle pacing lead in conjunction with a transvenous pacemaker/ICD in an adult with Levo-Transposition of the Great Arteries (L-TGA) and a stenotic coronary sinus (CS) ostium (os), which would not accommodate a transvenous LV pacing lead. Nonselective His bundle pacing provided a nearly identical ventricular activation pattern in this previously unpaced patient. Many L-TGA patients will have an eventual need for permanent pacing and, given the challenges of CS cannulation, His bundle pacing may represent a preferred modality rather than pure morphologic LV pacing or surgical systemic ventricular lead placement to achieve optimal electrical synchrony. Read More

    Automated verification of pulmonary vein isolation in radiofrequency and cryoballoon guided ablation.
    Pacing Clin Electrophysiol 2017 May 25. Epub 2017 May 25.
    Ghent University Hospital, Heart Center, Ghent, Belgium.
    Background: Verification of pulmonary vein isolation (PVI) can be challenging due to the coexistence of pulmonary vein potentials (PVP) and far field potentials. This study aimed to prospectively validate a novel algorithm for automated verification of PVI in radiofrequency-guided (RF) and cryoballoon-guided (CB) ablation strategies.

    Methods: A dataset of 620 (RF: 516 EGMs and CB: 104 EGMs) bipolar electrograms (EGM), recorded by circular mapping catheter (CMC) placed at the left atrium-pulmonary vein (PV) junction, were prospectively analyzed by a two-step algorithm. Read More

    Right ventricular pacemaker lead position is associated with differences in long-term outcomes and complications.
    J Cardiovasc Electrophysiol 2017 May 24. Epub 2017 May 24.
    Department of Cardiovascular Diseases.
    Introduction: Cardiac pacing from the right ventricular apex is associated with detrimental long-term effects and non-apical pacing locations may be associated with improved outcomes. There is little data regarding complications with non-apical lead positions. The aim of this study was to assess long-term outcomes and lead-related complications associated with differing ventricular lead tip position. Read More

    Oral anticoagulation management in patients with atrial fibrillation undergoing cardiac implantable electronic device implantation.
    Clin Cardiol 2017 May 19. Epub 2017 May 19.
    Cardiac Electrophysiology Section, Duke Center for Atrial Fibrillation, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina.
    Background: Oral anticoagulation (OAC) therapy is associated with increased periprocedural risks after cardiac implantable electronic device (CIED) implantation. Patterns of anticoagulation management involving non-vitamin K antagonist oral anticoagulants (NOACs) have not been characterized.

    Hypothesis: Anticoagulation strategies and outcomes differ by anticoagulant type in patients undergoing CIED implantation. Read More

    Impact of treatment crossovers on clinical outcomes in the rate and rhythm control strategies for atrial fibrillation: Insights from the AFFIRM (atrial fibrillation follow-up investigation of rhythm management) trial.
    Pacing Clin Electrophysiol 2017 May 24. Epub 2017 May 24.
    Cardiac Arrhythmia Service and Heart Center, Massachusetts General Hospital, Boston, MA.
    We investigated the rates and reasons for crossover to alternative treatment strategies and its impact on mortality in patients who were enrolled in the AFFIRM trial. Over a mean follow-up period of 3.5 years, 842 patients underwent crossover to the alternative treatment arms in AFFIRM. Read More

    Stricter criteria for left bundle branch block diagnosis do not improve response to CRT.
    Pacing Clin Electrophysiol 2017 May 23. Epub 2017 May 23.
    Mediterranean Clinic, Naples, Italy.
    Background: Cardiac resynchronization therapy (CRT) has proved to be effective in patients with heart failure and left bundle branch block (LBBB). Recently, new ECG criteria have been proposed for the diagnosis of LBBB. These criteria are stricter than the current American Heart Association (AHA) criteria. Read More

    Comparison between local and systemic injection of adenosine for detecting dormant conduction after PV isolation.
    Pacing Clin Electrophysiol 2017 May 24. Epub 2017 May 24.
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
    Background: Adenosine administration after pulmonary vein (PV) isolation is effective for identifying dormant conduction (DC). We aimed to compare the efficacy and safety of local injection of adenosine into the PV with systemic intravenous injection.

    Methods: After complete PV isolation was performed, adenosine was injected directly into the PV (local method; 6-18 mg) and the femoral vein (systemic method, 12-30 mg) sequentially. Read More

    The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in dedicated goat and dog models.
    Br J Pharmacol 2017 May 24. Epub 2017 May 24.
    Department of Medical Physiology, University Medical Center Utrecht, The Netherlands.
    Background And Purpose: Inward rectifier current (IK1 ) density increases in atrial fibrillation (AF), shortening effective refractory period and thus promotes atrial reentry. Pentamidine-Analogue 6 (PA-6) is a selective and potent IK1 inhibitor. We tested PA-6 for anti-AF efficacy and potential proarrhythmia, in established large animal models. Read More

    Voxelwise distribution of acute ischemic stroke lesions in patients with newly diagnosed atrial fibrillation: Trigger of arrhythmia or only target of embolism?
    PLoS One 2017 24;12(5):e0177474. Epub 2017 May 24.
    Department of Neurology, University of Heidelberg, Heidelberg, Germany.
    Objective: Atrial fibrillation (AF) is frequently detected after ischemic stroke for the first time, and brain regions involved in autonomic control have been suspected to trigger AF. We examined whether specific brain regions are associated with newly detected AF after ischemic stroke.

    Methods: Patients with acute cerebral infarctions on diffusion-weighted magnetic resonance imaging were included in this lesion mapping study. Read More

    Antithrombotic therapy of patients with atrial fibrillation discharged after major non-cardiac surgery. 1-year follow-up. Sub-analysis of PRAGUE 14 study.
    PLoS One 2017 24;12(5):e0177519. Epub 2017 May 24.
    University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University Prague, Prague, Czech Republic.
    Background: The study investigated the discharge antithrombotic medication in patients with atrial fibrillation (AF) after major non-cardiac surgery and the impact on one-year outcomes.

    Methods: A subgroup of 366 patients (mean age 75.9±10. Read More

    Improvement of left ventricular diastolic function and left heart morphology in young women with morbid obesity six months after bariatric surgery.
    Cardiol J 2017 May 25. Epub 2017 May 25.
    Department of Internal Medicine and Cardiology, Medical University of Warsaw, Poland.
    Background: Obesity contributes to left ventricular diastolic dysfunction (LVDD) and may lead to diastolic heart failure. Weight loss (WL) after bariatric surgery (BS) may influence LV morphology and function. Using echocardiography, this study assessed the effect of WL on LV diastolic function (LVDF) and LV and left atrium (LA) morphology 6 months after BS in young women with morbid obesity. Read More

    Hypertension and Cardiac Arrhythmias: Executive Summary of a Consensus Document from the European Heart Rhythm Association (EHRA) and ESC Council on Hypertension, endorsed by the Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS) and Sociedad Latinoamericana de Estimulación Cardíaca y Electrofisiología (SOLEACE).
    Eur Heart J Cardiovasc Pharmacother 2017 May 25. Epub 2017 May 25.
    Institute of Cardiovascular Science, University College London, UK University College London, UK.
    Hypertension (HTN) is a common cardiovascular risk factor leading to heart failure (HF), coronary artery disease (CAD), stroke, peripheral artery disease and chronic renal failure. Hypertensive heart disease can manifest as many types of cardiac arrhythmias, most commonly being atrial fibrillation (AF). Both supraventricular and ventricular arrhythmias may occur in HTN patients, especially in those with left ventricular hypertrophy (LVH), CAD or HF. Read More

    Family history of atrial fibrillation as a predictor of atrial substrate and arrhythmia recurrence in patients undergoing atrial fibrillation catheter ablation.
    Europace 2017 May 24. Epub 2017 May 24.
    Cardiovascular Division, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
    Aims: A commonly held notion is that patients with a family history of atrial fibrillation (AF) have worse atrial substrate and higher rates of arrhythmia recurrence following ablation. We sought to examine differences in atrial substrate and catheter ablation outcomes in patients with a 1st degree family member with paroxysmal or persistent AF (PeAF) compared to those without.

    Methods And Results: A total of 256 consecutive patients undergoing their 1st ablation for AF (123 paroxysmal, 133 persistent) with >1 year follow up were included. Read More

    Does Type D Personality Impact on the Prognosis of Patients Who Underwent Catheter Ablation for Atrial Fibrillation? A 1-Year Follow-Up Study.
    Psychiatry Investig 2017 May 16;14(3):281-288. Epub 2017 May 16.
    Division of Cardiology, Department of Internal Medicine, Korea University Medical Center, Seoul, Republic of Korea.
    Objective: Although Type D personality has been associated with the prognosis of various cardiac diseases, few studies have investigated the influence of Type D personality on the cardiac and psychiatric prognoses of patients with atrial fibrillation (AF).

    Methods: Depression, anxiety, and quality of life were measured at baseline and 6 months. The recurrence of AF was measured during 1-year following radiofrequency catheter ablation (RFCA) for AF. Read More

    Development of a Basic Risk Score for Incident Atrial Fibrillation in a Japanese General Population - The Suita Study.
    Circ J 2017 May 25. Epub 2017 May 25.
    Department of Preventive Medicine, National Cerebral and Cardiovascular Center.
    Background: An atrial fibrillation (AF) risk score for a non-Western general population has not been established.Methods and Results:A total of 6,898 participants (30-79 years old) initially free of AF have been prospectively followed for incident AF since 1989. AF was diagnosed when AF or atrial flutter was present on ECG at a biannual health examination; was indicated as a current illness; or was in the medical records during follow-up. Read More

    Sex-Related Differences in the Clinical Events of Patients With Atrial Fibrillation - The Fushimi AF Registry.
    Circ J 2017 May 25. Epub 2017 May 25.
    Department of Cardiology, National Hospital Organization Kyoto Medical Center.
    Background: Female sex is considered a risk factor for thromboembolism in patients with atrial fibrillation (AF), and is included in the risk stratification scheme, CHA2DS2-VASc score. The purpose of the present study was to investigate the clinical outcomes of female Japanese AF patients.Methods and Results:The Fushimi AF Registry is a community-based prospective survey of the AF patients in Fushimi-ku, Kyoto. Read More

    Prognostic Value of Combination of Plasma D-Dimer Concentration and Estimated Glomerular Filtration Rate in Predicting Long-Term Mortality of Patients With Stable Coronary Artery Disease.
    Circ J 2017 May 25. Epub 2017 May 25.
    Department of Cardiology, Fujita Health University School of Medicine.
    Background: A modestly elevated circulating D-dimer level may be relevant to coronary artery disease (CAD), but its prognostic value, both independently and in combination with estimated glomerular filtration rate (eGFR), for long-term death has not been fully evaluated in stable CAD patients.Methods and Results:Baseline plasma D-dimer levels and eGFR were measured in 1,341 outpatients (mean age: 65 years) with prior myocardial infarction (MI), coronary revascularization, and/or angiographic evidence of a significant stenosis (>50%) for at least one of the major coronary arteries. Among these patients, 43% had prior MI, 47% had prior coronary revascularization, 41% had multivessel CAD, 14% had paroxysmal or persistent atrial fibrillation, 32% had diabetes, and 32% had chronic kidney disease (eGFR <60 mL/min/1. Read More

    Systemic Inflammation and Arrhythmogenesis: A Review of Mechanistic and Clinical Perspectives.
    Angiology 2017 Jan 1:3319717709380. Epub 2017 Jan 1.
    2 Cardiology Department, Trakya Üniversity, Edirne, Turkey.
    In the recent decades, systemic inflammation, as a clinical phenomenon, has been the focus of extensive research particularly with regard to its potential association with a variety of cardiovascular diseases including atherogenesis and acute coronary syndromes. Within this context, there also exists a potential link between systemic inflammation and cardiac arrhythmogenesis in various aspects. Accordingly, systemic inflammation response as measured with inflammation markers (cytokines, etc) has been investigated in the setting of well-known cardiac arrhythmias including atrial fibrillation and ventricular tachycardia. Read More

    Comparison of Two Central Venous Pressure Control Strategies to Prevent Atrial Fibrillation After Coronary Artery Bypass Grafting.
    Arq Bras Cardiol 2017 Apr;108(4):297-303
    Universidade Estadual de Ponta Grossa, Ponta Grossa, PR - Brazil.
    Background:: Atrial fibrillation (AF) takes place in 10-40% of patients undergoing coronary artery bypass grafting (CABG), and increases cardiovascular mortality. Enlargement of atrial chambers is associated with increased AF incidence, so patients with higher central venous pressure (CVP) are expected to have larger atrial distension, which increases AF incidence.

    Objective:: To compare post-CABG AF incidence, following two CVP control strategies. Read More

    SAMe-TT2R2 Score in the Outpatient Anticoagulation Clinic to Predict Time in Therapeutic Range and Adverse Events.
    Arq Bras Cardiol 2017 Apr;108(4):290-296
    Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS - Brazil.
    Background:: The SAMe-TT2R2 score was developed to predict which patients on oral anticoagulation with vitamin K antagonists (VKAs) will reach an adequate time in therapeutic range (TTR) (> 65%-70%). Studies have reported a relationship between this score and the occurrence of adverse events.

    Objective:: To describe the TTR according to the score, in addition to relating the score obtained with the occurrence of adverse events in patients with nonvalvular atrial fibrillation (AF) on oral anticoagulation with VKAs. Read More

    Atrial fibrillation was changed into sinus bradycardia in a ROS1-positive advanced lung adenocarcinoma patient who achieved durable response to Crizotinib: A case report and literature review.
    Medicine (Baltimore) 2017 May;96(21):e6979
    Department of Thoracic Oncology, Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan Province, China.
    Rational: The c-ros oncogene 1 receptor tyrosine kinase (ROS1)-rearrangements represent a new and rare genetic subtype of non-small-cell lung cancer. In recent years, the use of crizotinib in ROS1-rearranged lung cancer exhibits significant clinical efficacy. Crizotinib is generally well tolerated and the most frequent adverse events include visual disorders, gastrointestinal disturbances, cardiac, and endocrine abnormalities. Read More

    Cardiac Abnormalities in Type 1 Facioscapulohumeral Muscular Dystrophy.
    J Clin Neuromuscul Dis 2017 Jun;18(4):199-206
    Departments of *Cardiology and †Neurology, CHU de Caen, Caen, France; ‡Department of Neurology, CHU Charles Nicolle, Rouen, France; §Department of Neurology, CHU d'Amiens, Amiens, France; and ¶Department of Neurology, Rehabilitation Neuromuscular Disease Center, CHU de Caen, Caen, France.
    Objectives: We conducted a retrospective study to characterize the cardiac complications in patients with genetically confirmed type 1 facioscapulohumeral dystrophy.

    Methods: We reviewed baseline cardiac investigations, including electrocardiogram, Holter electrocardiogram and echocardiogram, as well as cardiac complications that occurred during follow-up in 56 adult patients (37 men, mean duration of disease: 20 years).

    Results: Baseline evaluation revealed minor cardiac anomalies in 23 patients including incomplete right bundle branch block (iRBBB) in 13 patients (23%). Read More

    Advances in Clinical Cardiology 2016: A Summary of the Key Clinical Trials.
    Adv Ther 2017 May 23. Epub 2017 May 23.
    Craigavon Cardiac Centre, Southern Trust, Craigavon, Northern Ireland, UK.
    Introduction: The findings of many new cardiology clinical trials over the last year have been published or presented at major international meetings. This paper aims to describe and place in context a summary of the key clinical trials in cardiology presented between January and December 2016.

    Methods: The authors reviewed clinical trials presented at major cardiology conferences during 2016 including the American College of Cardiology (ACC), European Association for Percutaneous Cardiovascular Interventions (EuroPCR), European Society of Cardiology (ESC), European Association for the Study of Diabetes (EASD), Transcatheter Cardiovascular Therapeutics (TCT), and the American Heart Association (AHA). Read More

    Comparison of early outcomes of surgical ablation procedures for atrial fibrillation concomitant to non-mitral cardiac surgery: a Japan Adult Cardiovascular Surgery Database study.
    Gen Thorac Cardiovasc Surg 2017 May 23. Epub 2017 May 23.
    Japan Cardiovascular Surgery Database Organization, Tokyo, Japan.
    Objective: Although the benefit of surgical ablation for atrial fibrillation (AF) performed concomitant to mitral valve surgery is established, whether that performed concomitant to non-mitral cardiac surgery is beneficial remains unclear. In non-mitral, non-left-atriotomy cardiac surgery, the optimal surgical approach for AF remains to be established. Therefore, using the Japan Adult Cardiovascular Surgery Database (JACVSD), we compared 2 surgical ablation procedures [the maze procedure and pulmonary vein isolation (PVI)] performed concomitant to non-mitral cardiac surgery. Read More

    Current Status of Bruton's Tyrosine Kinase Inhibitor Development and Use in B-Cell Malignancies.
    Drugs Aging 2017 May 23. Epub 2017 May 23.
    CLL Center and Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA.
    The B-cell receptor (BCR) pathway plays an important role in the survival, proliferation and trafficking of cancer cells in a variety of B-cell malignancies. Recently, a number of agents have been developed to target various components of the BCR pathway. One such target is Bruton's tyrosine kinase (BTK), a Tec family kinase member found near the cell membrane that is involved in upstream BCR signaling. Read More

    [Genetic testing in polygenic diseases : Atrial fibrillation, arterial hypertension and coronary artery disease].
    Herz 2017 May 23. Epub 2017 May 23.
    Deutsches Herzzentrum München, Klinik für Herz- und Kreislauferkrankungen, Technische Universität München, Lazarettstr. 36, 80636, München, Deutschland.
    Genetic testing plays an increasing role in cardiovascular medicine. Advances in technology and the development of novel and more affordable (high throughput) methods have led to the identification of genetic risk factors in research and clinical practice. Also, this progress has simplified the screening of patients and individuals at risk. Read More

    [Anticoagulation-direct oral anticoagulants].
    Internist (Berl) 2017 May 23. Epub 2017 May 23.
    Interdisziplinärer Schwerpunkt für Hämostaseologie, Universitätsklinikum Gießen und Marburg GmbH, Langhansstr. 2, 35392, Gießen, Deutschland.
    Since direct oral anticoagulants (DOAC) have become available, use of anticoagulant treatment has become easier and safer-for patients suffering from thromboembolic diseases as well as for patients with atrial fibrillation: Because of constant bioavailability, fixed dose regimen treatment is possible, monitoring not necessary and severe bleeding complications-particularly intracranial hemorrhages-rare in comparison to vitamin K anticoagulants. To gain all these advantages, it is essential to give DOAC in the correct dosage. Dose reduction of single DOAC has to be considered depending on underlying disease, body weight and renal function. Read More

    Association between Embolic Stroke Patterns, ESUS Etiology, and New Diagnosis of Atrial Fibrillation: A Secondary Data Analysis of the Find-AF Trial.
    Stroke Res Treat 2017 27;2017:1391843. Epub 2017 Apr 27.
    Department of Neurology, University Medicine Göttingen, Göttingen, Germany.
    Background. Atrial fibrillation (AF) is an important cause of embolic stroke of undetermined source (ESUS). Imaging-patterns like multiple infarcts, simultaneous involvement of different circulations, infarcts of different ages, and isolated cortical infarcts are likely to indicate cardioembolic stroke. Read More

    Chocolate intake and risk of clinically apparent atrial fibrillation: the Danish Diet, Cancer, and Health Study.
    Heart 2017 May 23. Epub 2017 May 23.
    Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
    Objective: To evaluate the association between chocolate intake and incident clinically apparent atrial fibrillation or flutter (AF).

    Methods: The Danish Diet, Cancer, and Health Study is a large population-based prospective cohort study. The present study is based on 55 502 participants (26 400 men and 29 102 women) aged 50-64 years who had provided information on chocolate intake at baseline. Read More

    Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: prospective cohort study.
    BMJ 2017 May 23;357:j2099. Epub 2017 May 23.
    Bristol Primary Clinical Commissioning Group and The National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care West (NIHR CLAHRC West) at University Hospitals Bristol NHS Foundation Trust, UK, UK.
    Objectives To develop and validate updated QRISK3 prediction algorithms to estimate the 10 year risk of cardiovascular disease in women and men accounting for potential new risk factors.Design Prospective open cohort study.Setting General practices in England providing data for the QResearch database. Read More

    Actual management and prognosis of severe isolated tricuspid regurgitation associated with atrial fibrillation without structural heart disease.
    Int J Cardiol 2017 May 11. Epub 2017 May 11.
    Department of Cardiology, Tenri Hospital, Tenri-City, Nara, Japan.
    Background: Patients with atrial fibrillation (AF) without structural heart diseases can show severe tricuspid regurgitation (TR), especially among aged people. The aim of this study was to clarify the actual management, prognosis, and prognostic factors for severe isolated TR associated with AF without structural heart diseases.

    Methods And Results: We retrospectively investigated actual management in 178 consecutive patients with severe isolated TR associated with AF between 1999 and 2011 in our institution. Read More

    Factors influencing postoperative atrial fibrillation in patients undergoing on-pump coronary artery bypass grafting, single center experience.
    J Cardiothorac Surg 2017 May 23;12(1):40. Epub 2017 May 23.
    King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.
    Background: The reported incidence of AF after CABG surgery varies from 20 to 40%, with the arrhythmia usually occurring between second and fourth postoperative days. Postoperative AF after CABG was associated with greater in-hospital mortality and worse survival at long-term follow-up. Therefore, intensive attention has focused on the prevention of AF in high-risk patients. Read More

    Adult Height, Prevalent Coronary Calcium Score, and Incident Cardiovascular Outcomes in a Multi-Ethnic Cohort.
    Am J Epidemiol 2017 May 23. Epub 2017 May 23.
    We assessed the relationships among adult height, coronary artery calcium (CAC) scores, incident atherosclerotic cardiovascular disease (ASCVD) events, and atrial fibrillation (Afib) in a multi-ethnic cohort. We used race/ethnicity -specific height (dichotomized by median and quartiles) as the predictor variable within the four race/ethnic groups in the Multi-Ethnic Study of Atherosclerosis (N = 6,814). After a mean of 10. Read More

    Comparison of Effectiveness and Safety of Treatment with Apixaban vs. Other Oral Anticoagulants Among Elderly Nonvalvular Atrial Fibrillation Patients.
    Curr Med Res Opin 2017 May 23:1-25. Epub 2017 May 23.
    d Novosys Health , Green Brook , NJ.
    Objective: To compare the risk of stroke/systemic embolism (S/SE) and major bleeding (MB) of elderly (≥65 years of age) nonvalvular atrial fibrillation (NVAF) patients initiating apixaban vs. rivaroxaban, dabigatran, or warfarin.

    Methods: NVAF patients with Medicare Advantage coverage in the US initiating oral anticoagulants (OACs, index event) were identified from the Humana database (1/1/2013-9/30/2015) and grouped into cohorts depending on OAC initiated. Read More

    Polysomnographic Heart Rate Variability Indices and Atrial Ectopy Associated with Incident Atrial Fibrillation Risk in Older Community-dwelling Men.
    JACC Clin Electrophysiol 2017 May;3(5):451-460
    Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA.
    Background: Autonomic dysfunction contributes to atrial fibrillation (AF).

    Objective: We hypothesized that polysomnogram (PSG)-based heart rate variability (HRV) autonomic function biomarkers are associated with incident AF and these associations are modified by measures of sleep disordered breathing (SDB).

    Methods: 2350 participants of a multi-center prospective study (Outcomes of Sleep Disorders in Older Men Study) without baseline AF underwent sleep studies with incident adjudicated AF follow up (8. Read More

    Atrial Fibrillation Dynamics and Ionic Block Effects in Six Heterogeneous Human 3D Virtual Atria with Distinct Repolarization Dynamics.
    Front Bioeng Biotechnol 2017 8;5:29. Epub 2017 May 8.
    Department of Computer Science, University of Oxford, Oxford, UK.
    Atrial fibrillation (AF) usually manifests as reentrant circuits propagating through the whole atria creating chaotic activation patterns. Little is yet known about how differences in electrophysiological and ionic properties between patients modulate reentrant patterns in AF. The goal of this study is to quantify how variability in action potential duration (APD) at different stages of repolarization determines AF dynamics and their modulation by ionic block using a set of virtual whole-atria human models. Read More

    [Epidemiology of the relationship between atrial fibrillation and heart failure].
    Pan Afr Med J 2017 2;26:116. Epub 2017 Mar 2.
    Service de Cardiologie, Centre Hospitalier Universitaire IBN ROCHD, Casablanca, Maroc.
    Atrial fibrillation and heart failure are diseases which often coexist aggravating prognosis and constituting a major public health problem. The aim of this study was to assess the prevalence of atrial fibrillation in patients with chronic heart failure and to determine the clinical profile of this group of patients. We conducted a retrospective descriptive study based on the registry of heart failure of the Department of Cardiology at the University Hospital Centre from June 2006 to March 2015. Read More

    Once-daily rivaroxaban for long-term stroke prevention in patients with atrial fibrillation.
    Eur Heart J Suppl 2016 Apr;18(Suppl D):D7-D15
    Unité de Rythmologie, GHI Le Raincy-Montfermeil, 10, Rue du Général-Leclerc, Montfermeil 93370, France.
    Oral anticoagulation is the long-term standard of care for preventing stroke in patients with atrial fibrillation (AF). However, anticoagulation is associated with an increased risk of bleeding, such that its use should be based on the absolute risks of stroke and bleeding, and the relative benefit-risk profile of the individual patient. Non-vitamin K antagonist oral anticoagulants, including rivaroxaban, are alternatives to vitamin K antagonists such as warfarin in this setting, and are supported in treatment guidelines as the optimal choice for patients with AF at moderate to high risk of stroke. Read More

    Benefits of once-daily dosing with non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation.
    Eur Heart J Suppl 2016 Apr 21;18(Suppl D):D1-D6. Epub 2016 Apr 21.
    Cardiovascular Medicine, Barts Health NHS Trust, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK.
    Atrial fibrillation (AF) is the most prevalent clinically relevant arrhythmia, affecting millions of individuals in Europe and the USA. Atrial fibrillation increases the risk of stroke; the long-term standard of care for prevention of AF-related stroke is anticoagulation. The use of anticoagulants should be based on the absolute risks of stroke and bleeding and the relative benefit-risk profile of the individual patient. Read More

    Predictive Value of Age-Adjusted Charlson Co-Morbidity Index for 1-, 3-, and 5-Year Mortality in Patients Requiring Transcatheter Mitral Valve Repair.
    Am J Cardiol 2017 Apr 27. Epub 2017 Apr 27.
    Advanced Cardiac Valve Center, Department of Medicine, Division of Cardiovascular Medicine, University of Virginia, Charlottesville, Virginia. Electronic address:
    Co-morbidities increase markedly with aging, and they often negatively affect its prognosis. Although mortality with transcatheter mitral valve repair (TMVr) is significantly less than for open mitral valve surgery in patients at high surgical risk, it remains a concern to identify which patients will benefit from this treatment. Some prognostic metrics have been reported to guide better patient selection; however, universal risk stratification measures have not been established. Read More

    Effect of Addition of a Statin to Warfarin on Thromboembolic Events in Japanese Patients With Nonvalvular Atrial Fibrillation and Diabetes Mellitus.
    Am J Cardiol 2017 Apr 27. Epub 2017 Apr 27.
    Nippon Medical School, Tama-Nagayama Hospital, Tokyo, Japan.
    Statins have been shown to decrease stroke risk in patients with cardiovascular risk factors but not to prevent recurrence of ischemic stroke in patients with atrial fibrillation (AF). The present subanalysis aimed to clarify the efficacy of combined use of warfarin and statins in patients with nonvalvular AF (NVAF) with coronary artery disease, diabetes mellitus (DM), or hypertension. The effects of adding statins to warfarin were compared with those of warfarin alone in patients with NVAF with the data set of J-RHYTHM Registry, a prospective, observational study with a 2-year follow-up. Read More

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