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    Efficiency of ranolazine in the patient with microvascular angina, atrial fibrillation and migraine.
    Wiad Lek 2016 ;69(6):832-837
    Department of Internal Therapy №1 of Vinnitsa National Pirogov Memorial Medical University, Vinnitsa, Ukraine.
    Microvascular angina (MVA) is rather a common form of stable ischemic coronary disease (CAD) as that such diagnosis is made in 20-30% of patients who previously underwent coronary angiography. The disease occurs three times more frequently in women than in men irrespective of age. Most of these patients are 45-60 years old. Read More

    [Antithrombotic therapy in patients with atrial flutter before planned cardioversion].
    Wiad Lek 2016 ;69(6):742-746
    ВИЩИЙ ДЕРЖАВНИЙ НАВЧАЛЬНИЙ ЗАКЛАД УКРАЇНИ "УКРАЇНСЬКА МЕДИЧНА СТОМАТОЛОГІЧНА АКАДЕМІЯ", ПОЛТАВА,УКРАЇНА.
    Introduction: atrium flutter and fibrillation are the heart rhythm disorders that increase the risk of life-dangerous complications, e.g. cardioembolic stroke, pulmonary embolism. Read More

    Suppression of Tumorigenicity 2 in Heart Failure With Preserved Ejection Fraction.
    J Am Heart Assoc 2017 Feb 18;6(2). Epub 2017 Feb 18.
    Mayo Clinic, Rochester, MN
    Background: Soluble suppression of tumorigenicity 2 (sST2) receptor is a biomarker that is elevated in certain systemic inflammatory diseases. Comorbidity-driven microvascular inflammation is postulated to play a key role in heart failure with preserved ejection fraction (HFpEF) pathophysiology, but data on how sST2 relates to clinical characteristics or inflammatory conditions or biomarkers in HFpEF are limited. We sought to determine circulating levels and clinical correlates of sST2 in HFpEF. Read More

    Comparison of the Extent of Coronary Artery Disease in Patients With Versus Without Interatrial Block and Implications for New-Onset Atrial Fibrillation.
    Am J Cardiol 2017 Jan 25. Epub 2017 Jan 25.
    Division of Cardiology, Queen's University, Kingston, Ontario, Canada. Electronic address:
    Interatrial block (IAB) represents delay or block of conduction between the atria. IAB has been shown to predict the development or recurrence of atrial fibrillation (AF) in various clinical scenarios. Few studies have examined the correlation between coronary artery disease and the prevalence of IAB and its impact on AF. Read More

    Association of warfarin with congestive heart failure and peripheral artery occlusive disease in hemodialysis patients with atrial fibrillation.
    J Chin Med Assoc 2017 Feb 14. Epub 2017 Feb 14.
    Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Institutes of Physiology and Clinical Medicine, National Yang-Ming University, Taipei, Taiwan, ROC. Electronic address:
    Background: The effect of warfarin on the risk of cardiovascular (CV) disease is unknown among chronic hemodialysis patients with atrial fibrillation (HD-AF).

    Methods: Population-based propensity score and prescription time-distribution matched cohort study including 6719 HD-AF patients with CHA2DS2-VASc score ≥ 2 were divided into warfarin users and nonusers and followed-up for CV events and death.

    Results: Warfarin treatment in HD-AF patients with AF preceding HD was associated with higher risks of developing congestive heart failure [hazard ratio (HR)=1. Read More

    Relation Between Ventricular Premature Complexes and Incident Heart Failure.
    Am J Cardiol 2017 Jan 25. Epub 2017 Jan 25.
    Division of Cardiology, Electrophysiology Section, University of California, San Francisco, California. Electronic address:
    Ventricular premature complexes (VPCs) may represent a reversible cause of heart failure (HF); however, the type of patients most prone remains unknown. This study leverages a large population-based database to examine interactions that might prove clinically useful in risk-stratifying patients with VPCs. We used the California Healthcare Cost and Utilization Project to identify patients with VPCs and incident systolic HF from January 1, 2005, to December 31, 2009. Read More

    Comparison of Pulmonary Venous and Left Atrial Remodeling in Patients With Atrial Fibrillation With Hypertrophic Cardiomyopathy Versus With Hypertensive Heart Disease.
    Am J Cardiol 2017 Jan 25. Epub 2017 Jan 25.
    Division of Cardiovascular Medicine, Ibaraki Prefectural Central Hospital, Kasama, Japan.
    Left ventricular diastolic dysfunction in hypertrophic cardiomyopathy (HC) increases susceptibility to atrial fibrillation. Although phenotypical characteristics of the hypertrophied left ventricle are clear, left atrial (LA) and pulmonary venous (PV) remodeling has rarely been investigated. This study aimed to identify differences in LA and PV remodeling between HC and hypertensive heart disease (HHD) using 3-dimensional computed tomography. Read More

    Healthcare resources and needs in anticoagulant therapy for patients with nonvalvular atrial fibrillation. SAMOA Study.
    Rev Clin Esp 2017 Feb 14. Epub 2017 Feb 14.
    Centro Hospitalario de Alta Resolución (CHARE) El Toyo, Almería, España.
    Introduction And Objectives: To determine, in the various medical specialties, the healthcare process for anticoagulated patients with nonvalvular atrial fibrillation, to determine the available and necessary resources and to identify potential areas of improvement in the care of these patients.

    Methods: We performed a cross-sectional survey of primary care and specialised physicians involved in the care of anticoagulated patients. The questionnaires referred to the healthcare process, the indication and prescription of anticoagulant therapy and the barriers and deficiencies present for these patients. Read More

    Correlations between electrocardiogram and biomarkers in acute pulmonary embolism: Analysis of ZATPOL-2 Registry.
    Ann Noninvasive Electrocardiol 2017 Feb 18. Epub 2017 Feb 18.
    Department of Pulmonary Circulation and Thromboembolic Diseases, The Medical Centre of Postgraduate Medication, European Health Centre Otwock, Otwock, Poland.
    Background: Electrocardiography (ECG) is still one of the first tests performed at admission, mostly in patients (pts) with chest pain or dyspnea. The aim of this study was to assess the correlation between electrocardiographic abnormalities and cardiac biomarkers as well as echocardiographic parameter in patients with acute pulmonary embolism.

    Methods: We performed a retrospective analysis of 614 pts. Read More

    Rivaroxaban Versus Dabigatran or Warfarin in Real-World Studies of Stroke Prevention in Atrial Fibrillation: Systematic Review and Meta-Analysis.
    Stroke 2017 Feb 17. Epub 2017 Feb 17.
    From the University of Birmingham Institute of Cardiovascular Sciences, City Hospital, Birmingham, United Kingdom (Y.B., H.D., A.S., G.Y.H.L.); Cardiovascular Center, Beijing Tongren Hospital, Capital Medical University, China (Y.B.); Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Science, Guangzhou, China (H.D.); and Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Denmark (G.Y.H.L.).
    Background And Purpose: This study was designed to evaluate the effectiveness and safety of rivaroxaban in real-world practice compared with effectiveness and safety of dabigatran or warfarin for stroke prevention in atrial fibrillation through meta-analyzing observational studies.

    Methods: Seventeen studies were included after searching in PubMed for studies reporting the comparative effectiveness and safety of rivaroxaban versus dabigatran (n=3), rivaroxaban versus Warfarin (n=11), or both (n=3) for stroke prevention in atrial fibrillation.

    Results: Overall, the risks of stroke/systematic thromboembolism with rivaroxaban were similar when compared with those with dabigatran (stroke/thromboembolism: hazard ratio, 1. Read More

    Effects of dabigatran according to age in atrial fibrillation.
    Heart 2017 Feb 17. Epub 2017 Feb 17.
    McMaster University and Hamilton Health Sciences, Population Health Research Institute, Hamilton, Ontario, Canada.
    Objective: The prevalence of atrial fibrillation (AF) and the risk of stroke and bleeding vary according to age. To estimate effects of dabigatran, compared with warfarin, on stroke, bleeding and mortality in patients with AF in the Randomized Evaluation of Long-Term Anticoagulant Therapy (RE-LY) trial according to age, we analysed treatment effects using age as a continuous variable and using age categories.

    Methods: RE-LY included 10 855 (59. Read More

    Interleukin-1β levels predict long-term mortality and need for heart transplantation in ambulatory patients affected by idiopathic dilated cardiomyopathy.
    Oncotarget 2017 Feb 15. Epub 2017 Feb 15.
    Cardiovascular Department, Azienda Sanitaria Universitaria Integrata di Trieste and University of Trieste, Trieste, Italy.
    Aims: The prognostic stratification of patients with Idiopathic Dilated Cardiomyopathy (iDCM) is a difficult task. Here, we assessed the additive value of the evaluation of biomarkers of inflammasome activation and systemic inflammation for the long-term risk stratification of iDCM patients.

    Methods And Results: We studied 156 ambulatory iDCM patients (mean age 58 years, 77% men, 79% in NYHA class 1-2, median Left Ventricular Ejection Fraction (LVEF) 35%, mean sodium 139 mEq/L, median BNP 189 pg/mL, median IL-1 beta (IL-1β) 1. Read More

    Long-term prognosis after acute heart failure: a differential impact of age in different age strata.
    J Cardiovasc Med (Hagerstown) 2017 Feb 15. Epub 2017 Feb 15.
    aFaculdade de Medicina da Universidade do Porto bServiço de Medicina Interna, Hospital CUF Porto cServiço de Medicina Interna, Centro Hospitalar São João, Porto, Portugal.
    Background: Increasing age predicts ominous prognosis in heart failure. Age influences the success of therapeutic approaches and interacts with other prognostic predictors. We aimed to study the impact of age in long-term survival in different age strata. Read More

    End-stage renal disease and severe aortic stenosis: Does valve replacement improve one-year outcomes?
    Catheter Cardiovasc Interv 2017 Feb 17. Epub 2017 Feb 17.
    Structural Heart and Valve Center, Divisions of Cardiology, Emory University School of Medicine, Atlanta, Georgia.
    Background: Treatment for patients with end-stage renal disease (ESRD) and severe aortic stenosis (AS) includes balloon aortic valvuloplasty (BAV), surgical (SAVR), or transcatheter (TAVR) aortic valve replacement. We compared outcomes among these strategies.

    Methods: A retrospective review of patients with ESRD undergoing treatment for severe AS between 07/2007 and 06/2015 was performed at our center. Read More

    Recurrences in the Blanking Period and 12-Month Success Rate by Continuous Cardiac Monitoring after Cryoablation of Paroxysmal and Non-Paroxysmal Atrial Fibrillation.
    J Cardiovasc Electrophysiol 2017 Feb 17. Epub 2017 Feb 17.
    University of Florence, Heart and Vessels Department, Florence, Italy.
    Introduction: Recurrences within the blanking period (early recurrences) are common after atrial fibrillation (AF) ablation by pulmonary vein isolation (PVI), but their clinical significance is still controversial. We aimed at evaluating the significance of within-blanking recurrences at 12-month follow-up after cryoballoon (CB) PVI, and to assess the real procedural success rate by continuous monitoring of cardiac rhythm.

    Methods And Results: Sixty consecutive AF patients (34 paroxysmal, 56. Read More

    Comparison of Left Atrial Voltage Between Sinus Rhythm and atrial Fibrillation in Association with Electrogram Wave Form.
    Pacing Clin Electrophysiol 2017 Feb 16. Epub 2017 Feb 16.
    Kansai Rosai Hospital Cardiovascular Center, Amagasaki, Hyogo, Japan.
    Background: The efficacy of low-voltage-guided ablation in addition to pulmonary vein (PV) isolation for atrial fibrillation (AF) has been reported with voltage mapping being performed during sinus rhythm (SR) or AF. The study aimed to compare the left atrial voltage between SR and AF in association with the electrogram wave form.

    Methods: This prospective observational study included 30 consecutive patients with persistent AF. Read More

    Real-life experience with the specific reversal agent idarucizumab for the management of emergency situations in dabigatran-treated patients: a series of 11 cases.
    J Thromb Thrombolysis 2017 Feb 16. Epub 2017 Feb 16.
    General Hospital Jesenice, Jesenice, Slovenia.
    Non-vitamin K antagonist oral anticoagulants (NOACs) have a favorable benefit-risk profile compared with vitamin K antagonists. However, the lack of specific reversal agents has made the management of some patients receiving long-term treatment with NOACs problematic in emergency situations such as major bleeding events or urgent procedures. Idarucizumab, a fully humanized Fab antibody fragment that binds specifically and with high affinity to dabigatran, was recently approved for use in adult patients treated with dabigatran when rapid reversal of its anticoagulant effect is required. Read More

    Alcohol and Cardiovascular Disease: How Much is Too Much?
    Curr Atheroscler Rep 2017 Mar;19(3):13
    McMaster University, Hamilton, ON, Canada.
    Purpose Of Review: Previous research suggests that low-moderate alcohol consumption may have cardioprotective effects, while heavy or binge-pattern drinking is harmful. New evidence and research methodology may inform safe thresholds of alcohol use. This review examines recent evidence regarding alcohol's effect on cardiovascular disease, with a special consideration of pattern, drink type, and total quantity. Read More

    Anomalous Origin of the Left Coronary Artery From the Pulmonary Artery: An Uncommon Coronary Anomaly With Serious Implications in Adulthood.
    J Investig Med High Impact Case Rep 2017 Jan-Mar;5(1):2324709616684629. Epub 2017 Jan 1.
    Department of Internal Medicine, Division of Cardiology, East Tennessee State University, Johnson City, TN, USA.
    A 36-year-old woman was seen with complaints of exertional chest pain and shortness of breath. Her medical history included atrial fibrillation and diabetes. Physical examination was unremarkable except for an irregular cardiac rhythm. Read More

    Effect of vitamin D deficiency on the development of postoperative atrial fibrillation in coronary artery bypass patients.
    J Cardiovasc Thorac Res 2016 27;8(4):140-146. Epub 2016 Dec 27.
    Department of Cardiovascular Surgery, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.
    Introduction: Various factors may be responsible for the development of postoperative atrial fibrillation (POAF) in coronary artery bypass graft (CABG) patients. In our study, we demonstrated the effect of vitamin D deficiency on the development of POAF. Methods: In this prospective case control study, patients undergoing elective, isolated CABG were considered. Read More

    Impact of contact force technology on reducing the recurrence and major complications of atrial fibrillation ablation: A systematic review and meta-analysis.
    Anatol J Cardiol 2017 Feb;17(2):82-91
    Pacing and Electrophysiological Department, the First Affiliated Hospital of Xinjiang Medical University; Urumqi, Xinjiang-P. R. China.
    Contact force (CF) monitoring can be useful in accomplishing circumferential pulmonary vein (PV) isolation for atrial fibrillation (AF). This meta-analysis aimed to assess the efficacy and safety of a CF-sensing catheter in treating AF. Randomized controlled trials or non-randomized observational studies comparing AF ablation using CF-sensing or standard non-CF (NCF)-sensing catheters were identified from PubMed, EMBASE, Cochrane Library, Wanfang Data, and China National Knowledge Infrastructure (January 1, 1998-2016). Read More

    Edoxaban for the Prevention of Thromboembolism in Patients with AtrialFibrillation and Bioprosthetic Valves.
    Circulation 2017 Feb 16. Epub 2017 Feb 16.
    Thrombolysis in Myocardial Infarction (TIMI) Study Group, Boston, MA
    Atrial fibrillation (AF) and valvular heart disease (VHD) frequently coexist and independently increase mortality1. Bioprosthetic valve implantation (surgical or transcatheter), is a common, increasingly utilized treatment for VHD2. Patients with AF and bioprosthetic valves require anticoagulation to prevent thromboembolic events. Read More

    Pharmacologic cardioversion with intravenous amiodarone is likely safe in neurocritically Ill patients.
    J Clin Neurosci 2017 Feb 13. Epub 2017 Feb 13.
    Departments of Neurology and Neurocritical Care, Cedars-Sinai Medical Center, 127 S. San Vicente Blvd, Suite A6600, Los Angeles, CA 90048, United States. Electronic address:
    Neurological injury is often associated with cardiac abnormalities, including electrophysiological issues. Cardioversion of acute atrial fibrillation (<48h' duration) without anticoagulation carries about a 0.7% risk of thromboembolism. Read More

    Excessive daytime sleepiness in a patient with coexisting myotonic dystrophy type 1, myasthenia gravis and Graves' disease.
    Neurol Neurochir Pol 2017 Feb 3. Epub 2017 Feb 3.
    Department of Neurology, Medical University of Bialystok, Bialystok, Poland. Electronic address:
    A 41-year-old female with history of Graves' disease, bilateral cataract, paroxysmal atrial fibrillation was admitted because of muscle weakness, daytime sleepiness, fatigability, drowsiness, bilateral eyelid ptosis, descending of head and lower jaw. On neurological examination the patient was presented with muscle weakness, muscle atrophy (in face and sternocleidomastoid muscles), features of myotonia and apocamnosis (orbicular muscles). Electromyography revealed myopathic changes, myotonic and pseudomyotonic discharges, positive repetitive nerve stimulation test in proximal muscles. Read More

    Increased risk of thromboembolic events in adult congenital heart disease patients with atrial tachyarrhythmias.
    Int J Cardiol 2017 Feb 5. Epub 2017 Feb 5.
    Cardiovascular Division, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
    Background: Atrial tachyarrhythmias are a major morbidity in patients with adult congenital heart disease (ACHD). However, few studies have investigated risk stratification of thromboembolic events in ACHD patients with atrial tachyarrhythmias.

    Methods And Results: This retrospective cohort study reviewed the clinical records of 2314 ACHD patients from 1977 to 2014. Read More

    The Changing Landscape for Stroke Prevention in AF: Findings From the GLORIA-AF Registry Phase 2.
    J Am Coll Cardiol 2017 Feb;69(7):777-785
    University of Birmingham Institute of Cardiovascular Sciences, City Hospital, Birmingham, United Kingdom.
    Background: GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non-vitamin K antagonist oral anticoagulant (NOAC), became available.

    Objectives: This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Read More

    Reversal of Direct Oral Anticoagulants: Current Status and Future Directions.
    Semin Respir Crit Care Med 2017 Feb 16;38(1):40-50. Epub 2017 Feb 16.
    Department of Medicine and Biochemistry and Biomedical Sciences, Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario, Canada.
    Direct oral anticoagulants (DOACs) are increasingly used for prevention and treatment of venous thromboembolism and for prevention of stroke in patients with nonvalvular atrial fibrillation. In phase III clinical trials that included more than 100,000 patients, the DOACs were at least as effective as vitamin K antagonists (VKAs) and were associated with less serious bleeding, particularly less intracranial bleeding. Real-world evidence supports these outcomes. Read More

    First Diagnosis of Atrial Fibrillation at the Time of Stroke.
    Cerebrovasc Dis 2017 Feb 17;43(3-4):192-199. Epub 2017 Feb 17.
    Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA.
    Background: Atrial fibrillation (AF) is a major cause of ischemic stroke. Individuals with undiagnosed AF lack the stroke protection afforded by oral anticoagulants. We obtained a contemporary estimate of the percentage of AF patients newly diagnosed at the time of stroke. Read More

    ABCB1 and SLCO1B3 Gene Polymorphisms and Their Impact on Digoxin Pharmacokinetics in Atrial Fibrillation Patients among the Tunisian Population.
    Pharmacology 2017 Feb 17;99(5-6):250-258. Epub 2017 Feb 17.
    Research Laboratory (LR12SP18), University of Monastir, Monastir, Tunisia.
    Background: Digoxin is a substrate of P-glycoprotein (P-gp) and organic anion transporting polypeptide transporters that are encoded by ABCB1 and SLCO1B3 genes. Genetic polymorphisms in both genes may explain inter-individual variability of serum digoxin concentration (SDC). This study evaluates the possible effect of the most common ABCB1 and SLCO1B3 polymorphisms on SDC after a single oral dose of digoxin in Tunisian atrial fibrillation (AF) patients. Read More

    Factors Related to Cardioembolism as Major Predictors of Poor Survival after First-Ever Middle Cerebral Artery Stroke Treated with Thrombolysis.
    Cerebrovasc Dis 2017 Feb 17;43(3-4):178-185. Epub 2017 Feb 17.
    Department of Neurology, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, Brazil.
    Background And Purpose: Prognostic factors related to mortality rates after stroke have been reported; however, most studies included different treatments and did not focus solely on ischemic stroke. The study aimed to report the short- and long-term survival and predictors of death in patients with first-ever ischemic stroke in the middle cerebral artery (MCA) territory, submitted to intravenous thrombolysis (IVT).

    Methods: A prospective observational cohort study of patients with first-ever ischemic stroke in the MCA territory treated with IVT from March 2010 to February 2015 was conducted, and patients were followed up until May 2015. Read More

    Isolated cardiac troponin rise does not modify the prognosis in elderly patients with hip fracture.
    Medicine (Baltimore) 2017 Feb;96(7):e6169
    aSorbonne Universités UPMC Univ Paris 06, DHU FAST bUMRS INSERM 1166, IHU ICAN cUMRS INSERM 1158 dDepartment of Geriatry eDepartment of Anesthesiology and Critical Care fDepartment of Emergency Medicine and Surgery gDepartment of Orthopedic Surgery and Trauma Groupe Hospitalier (GH) Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris (APHP), Paris, France hDepartments of Anesthesia & Clinical Epidemiology and Biostatistics, Michael DeGroote School of Medicine, Population Health Research Institute, Perioperative Medicine and Surgical Research Unit, Faculty of Health Sciences, McMaster University, Hamilton, Canada iDepartment of Rehabilitation, GH Charles Foix, APHP, Ivry sur Seine jCentre National de la Recherche Scientifique (CNRS), Paris, France.
    Perioperative myocardial infarction remains a life-threatening complication in noncardiac surgery and even an isolated troponin rise (ITR) is associated with significant mortality. Our aim was to assess the prognostic value of ITR in elderly patients with hip fracture.In this cohort study, all patients admitted between 2009 and 2013 in our dedicated geriatric postoperative unit after hip fracture surgery with a cardiac troponin I determination were included and divided into Control, ITR, and acute coronary syndrome (ACS) groups. Read More

    Personalized models of human atrial electrophysiology derived from endocardial electrograms.
    IEEE Trans Biomed Eng 2016 May 30. Epub 2016 May 30.
    Objective: Computational models represent a novel framework for understanding the mechanisms behind atrial fibrillation (AF) and offer a pathway for personalizing and optimizing treatment. The characterization of local electrophysiological properties across the atria during procedures remains a challenge. The aim of this work is to characterize the regional properties of the human atrium from multi-electrode catheter measurements. Read More

    Plasma oxidative stress and inflammatory biomarkers are associated with the sizes of the left atrium and pulmonary vein in atrial fibrillation patients.
    Clin Cardiol 2017 Feb 16. Epub 2017 Feb 16.
    Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
    Background: Oxidative stress and inflammatory processes are responsible for the pathogenesis of AF, but their relationship with the sizes of the LA and PVs in AF patients remains unclear.

    Hypothesis: Oxidative stress and inflammatory processes are associated with the sizes of the LA and PVs in AF patients.

    Methods: 82 AF patients were compared to 30 control patients by using a case-control study design. Read More

    Association evidence of CCTTT repeat polymorphism in the iNOS promoter and the risk of atrial fibrillation in Taiwanese.
    Sci Rep 2017 Feb 13;7:42388. Epub 2017 Feb 13.
    Cardiovascular Division, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Tao-Yuan, Taiwan.
    Inducible nitric oxide synthase (iNOS) plays an important role in the pathogenesis of atrial fibrillation (AF). The iNOS promoter has a CCTTT-repeat length polymorphism that can determine the level of gene transcription. This study enrolled 200 AF patients and 240 controls. Read More

    Risk of major bleeding and stroke associated with the use of VKAs, NOACs and aspirin in patients with atrial fibrillation: a cohort study.
    Br J Clin Pharmacol 2017 Feb 16. Epub 2017 Feb 16.
    Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute of Pharmaceutical Sciences, Utrecht, the Netherlands.
    Introduction: Non-vitamin K antagonist oral anticoagulants (NOACs) are now available for the prevention of stroke in patients with atrial fibrillation (AF) as an alternative to vitamin K antagonists (VKA) and aspirin. The comparative effectiveness and safety in daily practice of these different drug classes is still unclear. The objective of this study was to evaluate the risk of major bleeding and stroke in AF patients using NOACs, VKAs or aspirin. Read More

    Use of three-dimensional computed tomography overlay for real-time cryoballoon ablation in atrial fibrillation reduces radiation dose and contrast dye.
    Neth Heart J 2017 Feb 15. Epub 2017 Feb 15.
    Thorax Centre Twente, Medisch Spectrum Twente, Enschede, The Netherlands.
    Aims: Cryoballoon pulmonary vein (PV) isolation in patients with atrial fibrillation has proven to be effective in short-term and long-term follow-up. To visualise the PV anatomy, pre-ablation contrast pulmonary venography is commonly performed. Three-dimensional (3D) computed tomography (CT) overlay is a new technique creating a live 3D image of the left atrium by integrating a previously obtained CT scan during fluoroscopy. Read More

    [Remodeling of the aging heart : Sinus node dysfunction and atrial fibrillation].
    Herzschrittmacherther Elektrophysiol 2017 Feb 15. Epub 2017 Feb 15.
    Institut für Physiologie, Abteilung II, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Hermann-Herder-Str. 7, 79104, Freiburg, Deutschland.
    The incidence of both sinus node dysfunction (SND) and atrial fibrillation (AF) increases with age. SND and AF frequently coexist. Likewise, they are often associated with cardiovascular diseases. Read More

    [Acute chest pain and new ECG changes in pacemaker patients : A clinical challenge].
    Herzschrittmacherther Elektrophysiol 2017 Feb 15. Epub 2017 Feb 15.
    Klinik für Innere Medizin I, Universitätsklinikum Jena, Erlanger Allee 101, 07740, Jena, Deutschland.
    We report the case of a 82-year-old woman who was admitted to our institution with acute chest pain, nausea, and vomiting. Because of atrial fibrillation with intermittent bradycardia, a single-chamber pacemaker was implanted 4 years ago. The initial 12-lead ECG showed atrial fibrillation with a heart rate of 70 bpm, narrow QRS, and T‑wave inversions in the inferolateral leads. Read More



    Robotic mitral valve repair for degenerative posterior leaflet prolapse.
    Ann Cardiothorac Surg 2017 Jan;6(1):27-32
    Background: Robotic mitral valve (MV) repair is the least invasive surgical approach to the MV and provides unparalleled access to the valve. We sought to assess technical aspects and clinical outcomes of robotic MV repair for isolated posterior leaflet prolapse by examining the first 623 such cases performed in a tertiary care center.

    Methods: We reviewed the first 623 patients (mean age 56±9. Read More

    Robotic cardiac surgery in Brazil.
    Ann Cardiothorac Surg 2017 Jan;6(1):17-26
    Centro de Cirurgia Cardíaca Minimamente Invasiva e Robótica, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
    Background: Brazil, the largest country and economy in South America, is a major driving force behind the development of new medical technologies in the region. Robotic cardiac surgery (RCS) has been evolving rapidly since 2010, when the first surgery using the DaVinci(®) robotic system was performed in Latin America. The aim of this article is to evaluate short and mid-term results in patients undergoing robotic cardiac surgery in Brazil. Read More

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