Search Our Scientific Publications & Authors

PLoS One 2019 24;14(4):e0215687. Epub 2019 Apr 24.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.

Background: Long-term variability of cardiometabolic risk factors have been suggested as the risk factors for cardiovascular disease and mortality. However, the effect of long-term variability of total cholesterol (TC) on incident atrial fibrillation (AF) has not been examined.

Methods And Findings: We explored whether visit-to-visit TC variability are associated with the risk of incident AF in 160,165 Korean adults, using the population-based Korean National Health Insurance Service-Health Screening Cohort (NHIS-HEALS) database, over a median duration of 8. Read More

Ann Noninvasive Electrocardiol 2019 Apr 24:e12651. Epub 2019 Apr 24.

Cardiology Division, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong SAR, China.

Background: Osteogenic circulating endothelial progenitor cells (EPC) play a pathogenic role in cardiovascular system degeneration through promulgating vasculature calcification, but its role in conduction disorders as part of the cardiovascular degenerative continuum remained unknown.

Aim: To investigate the role of osteocalcin (OCN)-expressing circulating EPCs in cardiac conduction disorders in the unique clinical sample of rheumatoid arthritis (RA) susceptible to both abnormal bone metabolism and cardiac conduction disorders.

Methods: We performed flow cytometry studies in 134 consecutive asymptomatic patients with rheumatoid arthritis to derive osteogenic circulating OCN-positive (OCN+) CD34+KDR+ vs. Read More

Am J Cardiovasc Drugs 2019 Apr 23. Epub 2019 Apr 23.

Division of Cardiology, Kaiser Permanente Los Angeles Medical Center, 1526 North Edgemont Street, 2nd Floor, Los Angeles, CA, 90027, USA.

Background: There is limited information on the risks and benefits of anticoagulation in patients with atrial fibrillation receiving peritoneal dialysis.

Objective: The aim was to determine the risk of mortality, ischemic stroke, and bleeding associated with warfarin use in patients with atrial fibrillation receiving peritoneal dialysis.

Patients And Methods: This is a retrospective observational study of a multi-ethnic cohort of patients with atrial fibrillation receiving peritoneal dialysis in the United States. Read More

Int J Clin Pharm 2019 Apr 17. Epub 2019 Apr 17.

Sydney Medical School, The University of Sydney, Edward Ford Building A27, Sydney, NSW, 2006, Australia.

Background The direct oral anticoagulants (DOACs) offer several advantages over warfarin in the management atrial fibrillation, including the provision of fixed dosing without a requirement for regular monitoring. Recently however the subject of DOAC monitoring has been probed after several post-hoc analyses demonstrated an association between plasma levels and efficacy and safety events. Objective The aim of this pilot study was to explore the acceptability of DOAC plasma monitoring amongst patients with atrial fibrillation and the factors that may influence these attitudes. Read More

J Interv Card Electrophysiol 2019 Apr 23. Epub 2019 Apr 23.

Department of Medicine and Geriatrics, Princess Margaret Hospital, 2-10 Princess Margaret Hospital Road, Lai Chi Kok, Kowloon, Hong Kong.

Purpose: We aimed to study the long-term outcomes of cryoballoon (CB) pulmonary vein isolation (PVI) in treating Chinese patients with atrial fibrillation (AF).

Methods: A total of 122 patients (48 women, mean age 57.4 ± 11. Read More

Eur J Clin Pharmacol 2019 Apr 23. Epub 2019 Apr 23.

Preventive Cardiology and Rehabilitation Unit, DSB 29 "S. Gennaro dei Poveri Hospital", Via S. Gennaro dei Poveri 25, 80136, Naples, Italy.

Int J Cardiol Heart Vasc 2019 Jun 15;23:100360. Epub 2019 Apr 15.

Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, Essen, Germany.

Pharm Pract (Granada) 2019 Jan-Mar;17(1):1349. Epub 2019 Mar 18.

Department of Pharmacy, Faculty of Medicine and Surgery, University of Malta. Msida (Malta).

Background: Optimisation of drug therapy is important in the older population and may be facilitated by medication assessment tools (MATs).

Objective: The purpose of the study was to evaluate whether appropriateness of drug therapy and clinical pharmacist intervention documentation improved following implementation of a previously developed MAT for the long-term management of atrial fibrillation (MAT-AF).

Methods: Adherence to MAT-AF review criteria and clinical pharmacist intervention documentation was assessed by the researcher pre-MAT implementation in 150 patients aged ≥60 years admitted to a rehabilitation hospital with a diagnosis of atrial fibrillation. Read More

BMJ Case Rep 2019 Apr 23;12(4). Epub 2019 Apr 23.

Hiram C. Polk Department of Surgery, University of Louisville, Louisville, Kentucky, USA.

Splenic laceration and rupture are common phenomena among patients in a traumatic setting, especially in blunt trauma. Much more unusual, however, is splenic injury without a known insult. Several case reports and studies have been written about spontaneous splenic injury in patients with viral, haematological or malignant processes. Read More

Br J Gen Pract 2019 Apr 23. Epub 2019 Apr 23.

Barts, and the London School of Medicine and Dentistry, Queen Mary University of London, London; research fellow, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge.

Background: Strong evidence on the long-term safety and efficacy of different types of anticoagulants would help clinicians to prevent thromboembolic events among patients with atrial fibrillation (AF) while minimising the risk of haemorrhages.

Aim: To estimate the risk of thromboembolic and haemorrhagic events for patients with AF on antiplatelets or anticoagulants.

Design And Setting: This was a cohort study using routinely collected UK primary and secondary care clinical data from patients with AF, aged ≥18 years, and with an indication to receive anticoagulation before April 2012. Read More

Clin Neurol Neurosurg 2019 Apr 15;181:68-72. Epub 2019 Apr 15.

Department of Neurology, Guangdong Second Provincial General Hospital, Guangzhou, 510000, Guangdong, China. Electronic address:

Objectives: Hemorrhagic transformation (HT) is a serious complication of acute cerebral infarction. The aim of study is to investigate the influencing factors of HT in non-thrombolysis patients with acute cerebral infarction, and to explore its clinical significance.

Patients And Methods: From June 2016 to March 2017, a total of 346 non-thrombolysis patients with acute cerebral infarction hospitalized in the Department of Neurology of Guangdong Second Provincial General Hospital, were chosen and randomly devided into the non-HT group (control) and HT group. Read More

Comput Biol Med 2019 Mar 14;108:276-287. Epub 2019 Mar 14.

Center for Arrhythmia Research, University of Michigan, Ann Arbor, MI, USA.

Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia and the most important cause of embolic stroke, requiring new technologies for its better understanding and therapies. Recent approaches to map the electrical activity during AF with multi-electrode systems aim at localizing patient-specific ablation targets of reentrant patterns. However, there is a critical need to determine the accuracy of those mapping systems. Read More

Heart Rhythm 2019 Apr 20. Epub 2019 Apr 20.

(5)Westmead Hospital, University of Sydney, New South Wales, Australia.

Access to the epicardial space is fundamental to several cardiac procedures. Whilst traditional indications include catheter ablation of ventricular arrhythmias and accessory pathways, novel indications include left atrial appendage occlusion, esophageal protection, mapping and ablation during atrial fibrillation procedures, implantation of epicardial pacing leads, and phrenic nerve displacement to facilitate safe ablation of arrhythmias. Accessing the epicardial space safely is a major challenge requiring intimate knowledge of cardiac anatomy, extensive training and expertise. Read More

J Cardiol 2019 Apr 20. Epub 2019 Apr 20.

Department of Cardiovascular Medicine, Nippon Medical School, Tokyo, Japan.

Background: Atrial fibrillation (AF) is characterized by a progression from paroxysmal to persistent or permanent AF. Recent studies have shown that AF progression is related to a worse morbidity and mortality, and poorer outcomes of radiofrequency catheter ablation (RFCA). We previously showed that left ventricular (LV) compliance assessed by diastolic wall strain (DWS) was a strong determinant of prevalent AF. Read More

Arch Cardiovasc Dis 2019 Apr 20. Epub 2019 Apr 20.

Department of Cardiology, Hôpital Bichat, AP-HP, 75018 Paris, France; Inserm U1148, Université Paris Diderot, 75877 Paris, France. Electronic address:

Background: Non-vitamin K antagonist oral anticoagulants (NOACs), including apixaban, are recommended for prevention of stroke and systemic embolism in non-valvular atrial fibrillation (NVAF).

Aims: To describe the characteristics of patients starting anticoagulant treatment, identify the characteristics associated with apixaban prescription, and describe apixaban use in France.

Methods: This was a non-interventional multicentre French study. Read More

J Cardiovasc Comput Tomogr 2019 Apr 17. Epub 2019 Apr 17.

Department of Cardiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands. Electronic address:

BMC Cardiovasc Disord 2019 Apr 23;19(1):94. Epub 2019 Apr 23.

Institute of General Practice, Goethe-University, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.

Background: Oral anticoagulants can cause potentially serious adverse events. Therefore, before prescribing oral anticoagulants for ischemic stroke prevention in patients with atrial fibrillation (AF), stroke risk assessment is required to identify patients that are likely to benefit from treatment. Current guidelines recommend the CHADS-VASc-score for stroke risk assessment. Read More

Korean J Intern Med 2019 Apr 25. Epub 2019 Apr 25.

Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea.

Background/aims: Efforts to reduce stroke in patients with atrial fibrillation (AF) have focused on increasing physician adherence to oral anticoagulant (OAC) guidelines; however, the high early discontinuation rate of vitamin K antagonists (VKAs) is a limitation. Although non-VKA OACs (NOACs) are more convenient to administer than warfarin, their lack of monitoring may predispose patients to nonpersistence. We compared the persistence of NOAC and VKA treatment for AF in real-world practice. Read More

Oman Med J 2013 Nov;28(6):e061

Department of Cardilogy, Shere-Kashmir-Institute of Medical Sciences (SKIMS) Srinagar, J&K. 190011.

Electric injury can cause a variety of cardiac arrhythmias. Atrial fibrillation as a result of such injury is very rare. We present a case of a young asymptomatic patient who developed acute atrial fibrillation with antegrade conduction over the atrioventricular bypass tract and very high ventricular rate after accidental low voltage electric injury, which was reverted successfully by DC shock. Read More

J Thromb Haemost 2019 Apr 23. Epub 2019 Apr 23.

Arianna Anticoagulazione Foundation, Bologna, Italy.

Background: Direct oral anticoagulants (DOACs) are administered at fixed dose. Aim of the study was to evaluate the relationship between DOAC C-trough or C-peak plasma levels, and bleeding complications in patients with non-valvular atrial fibrillation (NVAF).

Methods: 565 consecutive naive NVAF patients were enrolled. Read More

Heart Surg Forum 2019 Mar 11;22(2):E149-E154. Epub 2019 Mar 11.

Atatürk University, Medical Faculty, Department of Cardiovascular Surgery, Erzurum, Turkey.

Background: We investigated whether the use of aspirin (irreversible COX1 inhibitor) in the preoperative period may prevent non-valvular atrial fibrillation, which is the most common rhythm problem in the postoperative period. Non-valvular atrial fibrillation after coronary surgery may lead to an increase in hospital costs due to excessive drug use and long-term hospitalization.

Methods: More than 1000 coronary artery bypass grafting operations were performed between January 2011 to and Nov 2018. Read More

Heart Surg Forum 2019 Mar 11;22(2):E140-E148. Epub 2019 Mar 11.

Department of Laboratory, the First People's Hospital of Xianyang City, Xianyang, Shaanxi Province, China.

Background: MicroRNAs (miRNAs) are widely involved in the regulation of physiological processes, such as cell proliferation, differentiation, apoptosis, angiogenesis, and lipid metabolism. They might be associated with the pathological process of atrial fibrillation (AF). The purpose of our study is to investigate whether plasma miRNA-155 levels have a relationship with AF recurrence. Read More

Circulation 2019 Apr;139(17):e889

Brain Behav 2019 Apr 22:e01291. Epub 2019 Apr 22.

Department of Neurology, People's Hospital of Deyang City, Deyang, China.

Objectives: The mechanisms of ischemic stroke severity and early neurologic deterioration (END) are not fully understood. The aim of the present study was to investigate the association of six variants in MMP-9 gene with ischemic stroke severity and the risk for END in ischemic stroke (IS) patients with atrial fibrillation (AF).

Methods: This was a multi-center, prospective, observational study of 615 acute IS patients with AF admitted to six participating hospitals between June 2016 and October 2017. Read More

Cardiovasc Drugs Ther 2019 Apr 22. Epub 2019 Apr 22.

Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.

Background: Clinical guidelines recommend peri-cardioversion anticoagulation in patients with atrial fibrillation (AF). We performed a systematic review and meta-analysis to compare the safety and efficacy of direct oral anticoagulants (DOACs) versus vitamin K antagonists (VKAs) in patients with AF undergoing cardioversion.

Methods: We searched CENTRAL, MEDLINE, and EMBASE for randomized controlled trials (RCTs) and observational studies comparing DOACs to VKAs in patients undergoing cardioversion for AF. Read More

Res Pract Thromb Haemost 2019 Apr 5;3(2):207-216. Epub 2019 Mar 5.

Thrombosis Research Unit Department of Medicine I Division of Hematology University Hospital "Carl Gustav Carus" Dresden Dresden Germany.

Background: Exposure to vitamin K antagonists (VKA) has been suggested to accelerate progression of chronic kidney disease (CKD) but robust clinical data are currently lacking.

Methods: We retrospectively evaluated the impact of VKA exposure on kidney function in patients with atrial fibrillation (AF) and CKD stage 3/4. Patients were prospectively followed within a primary care electronic database (median follow-up of 1. Read More

Res Pract Thromb Haemost 2019 Apr 5;3(2):147-148. Epub 2019 Mar 5.

Departments of Medicine and Epidemiology University of Alabama at Birmingham Birmingham Alabama.

Stem Cells Int 2019 18;2019:9019648. Epub 2019 Mar 18.

Department of Cardiothoracic Surgery, Xiangya Hospital, Central South University, Changsha, 410008 Hunan, China.

Endothelial progenitor cells (EPCs) are a group of circulating cells with important functions in vascular repair and treatment of cardiovascular diseases. However, in patients with atrial fibrillation (AF), the number and function of EPCs reportedly are decreased. TGF- is highly expressed in AF patients. Read More

J Stroke Cerebrovasc Dis 2019 Apr 19. Epub 2019 Apr 19.

Division of Neurology, Department of Medicine, Jichi Medical University, Tochigi, Japan.

Isolated vertigo is an important symptom of posterior circulation stroke. It has been reported that 11.3% of patients with isolated vertigo have a stroke and that most lesions are located in the cerebellum, particularly in the posterior inferior cerebellar artery. Read More

Hipertens Riesgo Vasc 2019 Apr 19. Epub 2019 Apr 19.

Cátedra de Riesgo Cardiovascular, Universidad Católica de Murcia, IMIB Arrixaca, Murcia, España.

Acta Chir Belg 2019 Apr 23:1-16. Epub 2019 Apr 23.

b Department of Cardiology , Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital , Istanbul , Turkey.

Background: Postoperative atrial fibrillation (POAF) occurs frequently after lung cancer surgery. Unfortunately, owing to the multifactorial etiology of POAF, no single drug or intervention can prevent POAF in all cases. The effects of local interventions after lung cancer surgery are unknown. Read More

J Obstet Gynaecol 2019 Apr 22:1-2. Epub 2019 Apr 22.

a Department of Obstetrics and Gynaecology , Keele University School of Medicine, Princess Royal Hospital , Telford , UK.

Proclins Cardiol 2018 14;1(1):1005. Epub 2018 Dec 14.

Department of Medicine, Division of Cardiology, Heart and Vascular Institute, University of Pittsburgh, USA.

Background: Understanding racial differences in outcomes for atrial fibrillation (AF) may guide interventions to diminish health inequities.

Methods And Results: In a retrospective, cross-sectional study of adults hospitalized with a principal diagnosis of AF using the 2001-2012 National Inpatient Sample, we assessed racial differences for in-hospital. We accounted for case-mix and clustering by race within hospitals to estimate odds ratios (OR) for death associated with individual patient race and hospital racial composition. Read More

Eur Stroke J 2017 Dec 5;2(4):287-307. Epub 2017 Oct 5.

Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.

Purpose: Translating research evidence into clinical practice often uses key performance indicators to monitor quality of care. We conducted a systematic review to identify the stroke key performance indicators used in large registries, and to estimate their association with patient outcomes.

Method: We sought publications of recent (January 2000-May 2017) national or regional stroke registers reporting the association of key performance indicators with patient outcome (adjusting for age and stroke severity). Read More

Eur Stroke J 2017 Sep 5;2(3):222-228. Epub 2017 Jul 5.

Department of Cardiology, University Hospitals Antwerp, Antwerp, Belgium.

Purpose: A substantial number of patients without a history of atrial fibrillation who undergo surgery develop one or more episodes of atrial fibrillation in the first few days after the operation. We studied whether postoperative transient atrial fibrillation is a risk factor for future atrial fibrillation, stroke and death.

Method: We performed a narrative review of the literature on epidemiology, mechanisms, risk of atrial fibrillation, stroke and death after postoperative atrial fibrillation. Read More

Eur Stroke J 2016 Jun 1;1(2):76-84. Epub 2016 Jun 1.

Stroke and Vascular Research Centre, University of Manchester, Institute of Cardiovascular Sciences; Greater Manchester Neurosciences Centre, Salford Royal NHS Foundation Trust, Salford, UK.

Purpose: Several risk stratification scores for predicting stroke-associated pneumonia have been derived. We aimed to evaluate the performance and clinical usefulness of such scores for predicting stroke-associated pneumonia.

Method: A systematic literature review was undertaken in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement, with application of the Quality Assessment of Diagnostic Accuracy-2 tool. Read More

Eur Stroke J 2016 Mar 1;1(1):41-50. Epub 2016 Mar 1.

Clinical Neurosciences, Neurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Background And Aims: Basilar artery occlusion is a most devastating form of stroke, and the current practice is to reverse it with revascularization therapies. Pharmacological thrombolysis, intravenous or intraarterial, has been adjuncted or replaced with invasive, endovascular thrombectomy procedures. The preferred approach remains unknown and many recanalizations are futile with no clinical benefit. Read More

Stroke 2019 May;50(5):1124-1129

From the Vascular Neurology, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China (X.-M.Y., X.-Q.Z., Y.-L.W., Z.-X.L., Y.-J.W.).

Background and Purpose- We aim to compare the risk of 1-year ischemic stroke recurrence and death for atrial fibrillation diagnosed after stroke (AFDAS), atrial fibrillation known before stroke (KAF), and sinus rhythm (SR). Methods- From June 2012 to January 2013, 19 604 patients with acute ischemic stroke were admitted to 219 urban hospitals in the China National Stroke Registry II. Based on heart rhythm assessed during admission, we classified patients as AFDAS, KAF, or SR. Read More

Stroke 2019 May;50(5):1052-1059

From the Department of Cardiology (S. Riddersholm, B.T., K.K., P.S., S. Riahi), Aalborg University Hospital, Denmark.

Background and Purpose- After pneumonectomy or lobectomy, at least 1 blind pulmonary vein is left with potential risk of postoperative thromboembolic incidents. We investigated the risk of stroke within this population compared with background and pulmonary wedge resections controls. Methods- We identified 12 965 patients with pneumonectomy or lobectomy and 6400 patients with wedge resection using data from Danish nationwide registries from 1996 to 2016. Read More

Eur Heart J 2019 Apr 21. Epub 2019 Apr 21.

Division of Cardiology and Metabolism at Department of Cardiology (CVK); and Berlin-Brandenburg Center for Regenerative Therapies (BCRT); German Centre for Cardiovascular Research (DZHK) partner site Berlin; Charité Universitätsmedizin Berlin, Germany.

JAMA Intern Med 2019 Apr 22. Epub 2019 Apr 22.

Division of Cardiology, Queen's University, Kingston, Ontario, Canada.

Medicine (Baltimore) 2019 Apr;98(16):e14965

Department of Cardiology, The Second Affiliated Hospital of Soochow University.

Beraprost is used to treat peripheral chronic arterial occlusive disease. However, the efficacy and safety of beraprost in patients with pulmonary hypertension (PH) due to left ventricular systolic dysfunction (PH-HFrEF) remains unknown. The primary objective of this study was to determine the effects of beraprost on PH-HFrEF. Read More

Eur Stroke J 2018 Mar 15;3(1):92-93. Epub 2017 Sep 15.

1Stroke Unit, Department of Neurological and Neurosensorial Sciences, Azienda Ospedaliera Universitaria Senese, "Santa Maria alle Scotte" General Hospital, Siena, Italy.

Int J Cardiol Heart Vasc 2019 Jun 9;23:100358. Epub 2019 Apr 9.

National Heart Institute, Kuala Lumpur, Malaysia.

Background: Left atrial appendage closure is a non-pharmacological alternative for stroke prevention in high-risk non-valvular atrial fibrillation patients, but has not been widely studied in Asian patients. The prospective WASP registry assessed real-world outcomes for patients undergoing WATCHMAN implant in the Asia-Pacific region.

Methods: Data were collected from consecutive patients across 9 centres. Read More

Biomed Res Int 2019 17;2019:7636195. Epub 2019 Mar 17.

Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas LT-50161, Lithuania.

Atrial fibrillation (AF) despite the absence of heart failure is related to increased levels of natriuretic peptides (NPs). NPs have not been widely investigated in relation to left atrium (LA) function after sinus rhythm (SR) restoration and duration of AF. The aim of the study was to determine the changes of NPs levels and to define their relation with LA phasic function after electrical cardioversion (ECV). Read More

J Cardiovasc Echogr 2019 Jan-Mar;29(1):7-13

Department of Cardiology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

Aim: This study aims to propose protocols that enable scoring of mitral valve (MV) in mitral stenosis using the three-dimensional (3D) scoring system.

Methods: A two-staged study was conducted. The first stage was designed to select the best 3D images of MV leaflets and chordae through analysis of 471 images. Read More

J Cardiovasc Echogr 2019 Jan-Mar;29(1):1-6

Cardiomyopathies and Heart Failure Department, Monaldi Hospital, Università della Campania "Luigi Vanvitelli," Nocera Inferiore, Italy.

Introduction: In patients affected by hypertrophic cardiomyopathy (HCM), left atrial volume index (LAVi) is associated with an increased risk of tachyarrhythmias and major clinical events. To date, the clinical meaning of LAVi measured during exercise (stress LAVi [sLAVi]) has not yet been investigated in HCM. This study sought to evaluate the correlation between LAVi/sLAVi and clinical outcome (risk of arrhythmias and heart failure [HF]) in patients with HCM. Read More

Heart Views 2018 Jul-Sep;19(3):88-98

MetroHealth Medical Center, Case Western Reserve University, Heart and Vascular Institute, Cleveland, OH, USA.

Ranolazine is a piperazine derivative approved as an antianginal. Primarily used as a second-line antianginal in stable coronary artery disease. Ranolazine blocks the late Na + current and prevents the rise of cytosolic calcium. Read More

J Arrhythm 2019 Apr 15;35(2):300-302. Epub 2019 Feb 15.

Saiseikai Yokohamashi Tobu Hospital Yokohama-City, Kanagawa Japan.

A 23-year-old male with manifest Wolff-Parkinson-White syndrome presented with a first occurrence of ventricular fibrillation (VF). Initially, we anticipated the occurrence of atrial fibrillation, causing rapid antegrade conduction over the accessory pathway and, thus, resulting in hemodynamic deterioration. Electrophysiological study revealed that the atrioventricular accessory pathway was located at the mid-septum. Read More

J Arrhythm 2019 Apr 1;35(2):296-299. Epub 2019 Feb 1.

Electrophysiology and Arrhythmia Service Cardiology Division Department of Medicine Boston University Medical Center Boston Massachusetts.

Accessory pathway (AP) ablation failure may be related to multiple pathways which go unrecognized at the time of electrophysiology study. We present a patient who had two adjacent APs based on different preexcitation patterns as well as effective refractory periods (ERPs) which have not been previously described. Apart from leading to recurrent supraventricular tachycardia (SVT), multiple pathways are important to recognize as they more frequently predispose to malignant atrial arrhythmias. Read More