181,094 results match your criteria Atrial Fibrillation


Left Atrial Appendage Closure Device Implantation in Patients with Prior Intracranial Hemorrhage.

Heart Rhythm 2018 Nov 19. Epub 2018 Nov 19.

Section of Cardiac Pacing and Electrophysiology, Heart and Vascular Institute, Cleveland Clinic Foundation, Cleveland, OH. Electronic address:

Background: The Watchman™ device (Boston Scientific, MN), used for left atrial appendage closure (LAAC) was approved for stroke prevention in patients with atrial fibrillation (AF) and an appropriate rationale to avoid long-term oral anticoagulation. Patients with AF and prior intracranial hemorrhage (ICH) were excluded from clinical trials due to perceived risks of peri-operative anticoagulation.

Objective: We studied the efficacy and safety of LAAC using Watchman™ in patients with AF and prior ICH. Read More

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November 2018

Rapid and substantial increases in anticoagulant use and expenditure in Australia following the introduction of new types of oral anticoagulants.

PLoS One 2018 6;13(12):e0208824. Epub 2018 Dec 6.

National Centre for Epidemiology and Population Health, Australian National University, Canberra, Australia.

Objectives: To quantify changes in anticoagulant use in Australia since the introduction of Non-vitamin K antagonist anticoagulants (NOACs) and to estimate government expenditure.

Design: Interrupted-time-series analysis quantifying anticoagulant dispensing, before and after first Pharmaceutical Benefits Scheme (PBS) NOAC listing in August 2009 for venous thromboembolism prevention; and expanded listing for stroke prevention in non-valvular atrial fibrillation (AF) in August 2013, up to June 2016. Estimated government expenditure on PBS-listed anticoagulants. Read More

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December 2018

Insight into the perioperative management of direct oral anticoagulants: concerns and considerations.

Expert Opin Pharmacother 2018 Dec 6:1-8. Epub 2018 Dec 6.

d Division of Cardiology, Department of Medicine and Therapeutics , The Chinese University of Hong Kong, Prince of Wales Hospital , Hong Kong , China.

Introduction: Direct oral anticoagulants (DOACs) have gained momentum in recent years in patients requiring anticoagulation for the prevention and management of venous thromboembolism and thromboembolic events caused by atrial fibrillation. The use of these agents involves potential bleeding complications, particularly during invasive procedures. With increasing use of DOACs, adequate knowledge regarding the perioperative management of patients on DOACs has become indispensable. Read More

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December 2018

Effect of Postablation Statin Treatment on Arrhythmia Recurrence in Patients With Paroxysmal Atrial Fibrillation.

J Cardiovasc Pharmacol 2018 Dec;72(6):285-290

2nd Department of Cardiology, University of Athens Medical School, Attikon Hospital, Athens, Greece.

Background: Statins have been proposed as a means to prevent postablation atrial fibrillation (AF) recurrences, mainly on the basis of their pleiotropic effects. The objective of this subanalysis of a prospectively randomized controlled study population of patients undergoing radiofrequency ablation for paroxysmal AF was to test the hypothesis that statin treatment is associated with longer time to recurrence.

Methods And Results: This is a subanalysis over an extended follow-up period of a prospective randomized study (ClinicalTrials. Read More

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December 2018

Left Atrial Appendage Occlusion in the Management of Stroke in Patients With Atrial Fibrillation.

Cardiol Rev 2018 Dec 4. Epub 2018 Dec 4.

Division of Cardiology, New York Medical College/Westchester Medical Center, Valhalla, NY.

Atrial fibrillation (AF) is associated with a substantially higher risk of thromboembolism, particularly stroke events, resulting in significant morbidity and mortality. Oral anticoagulation (OAC), while effective in reducing embolic events in AF patients, is associated with an increased bleeding risk. Thus, not all patients with AF are candidates for OAC and some are only candidates for OAC in the short term. Read More

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December 2018
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Increased Vulnerability to Atrial Fibrillation Is Associated With Increased Susceptibility to Alternans in Old Sheep.

J Am Heart Assoc 2018 Dec;7(23):e009972

1 The University of Manchester United Kingdom.

Background Atrial fibrillation ( AF ) is common in the elderly, but rare in the young; however, the changes that occur with age that promote AF are not fully understood. Action potential ( AP ) alternans may be involved in the initiation of AF . Using a translationally relevant model, we investigated whether age-associated atrial vulnerability to AF was associated with susceptibility to AP alternans. Read More

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December 2018
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Apixaban-Associated Spontaneous Splenic Rupture-A Case Report.

Ir Med J 2018 08 13;111(7):792. Epub 2018 Aug 13.

University Hospital Galway, Ireland

Introduction A 62-year-old lady presented to The Emergency Department (ED) with one-day history of dizziness, vomiting and feeling weak. ECG showed new onset Atrial Fibrillation. Four days ago, she was referred to the Cardiology team where she underwent PCI and was discharged on Apixaban and Plavix. Read More

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Effects of sacubitril/valsartan on neprilysin targets and the metabolism of natriuretic peptides in chronic heart failure: a mechanistic clinical study.

Eur J Heart Fail 2018 Dec 6. Epub 2018 Dec 6.

Inserm UMR-S 942, Lariboisière Hospital, Paris, France.

Aim: This study aimed at evaluating the effects of sacubitril/valsartan on neprilysin (NEP), and the metabolism of natriuretic peptides in heart failure (HF) and providing additional mechanistic information on the mode of action of the drug.

Methods And Results: We enrolled 73 chronic HF patients who were switched from angiotensin-converting enzyme inhibitor or angiotensin receptor blocker to sacubitril/valsartan. In addition to clinical and echocardiographic assessment, plasma biomarkers were measured at baseline, day 30 and day 90 after initiation of treatment. Read More

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December 2018

Circular RNA expression profiles of persistent atrial fibrillation in patients with rheumatic heart disease.

Anatol J Cardiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Cardiology, Xijing Hospital, Air Force Military Medical University (Fourth Military Medical University); Xi'an-China.

Objective: To investigate the expression profile of circular RNAs (circRNAs) and proposed circRNA-microRNA (miRNA) regulatory network in atrial fibrillation (AF).

Methods: Atrial tissues from patients with persistent AF with rheumatic heart disease and non-AF myocardium with normal hearts were collected for circRNA differential expression analyses by high-throughput sequencing. The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed to predict the potential functions of the differentially expressed genes and AF-related pathways. Read More

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December 2018

Abstract 4: Safety of Intravenous Thrombolysis Among Patients Taking Direct Oral Anticoagulants: A Systematic Review and Meta-analysis.

Stroke 2018 Jan;49(Suppl_1):A4

Dept of Neurology, Danville, PA.

Introduction: Direct oral anticoagulants (DOACs) are increasingly being administered for atrial fibrillation and stroke prevention. The risk of symptomatic hemorrhagic transformation (sHT) following intravenous thrombolysis (IVT) among stroke patients who take DOACs is not clear.

Methods: We conducted a systematic review of literature through six different resources-PubMed, Scopus, Embase, Clinicaltrial. Read More

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January 2018

Novel Insights in the Activation Patterns at the Pulmonary Vein Area.

Circ Arrhythm Electrophysiol 2018 Nov;11(11):e006720

Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands (E.M.J.P.M., L.J.M.E.v.d.D., E.A.H.L., C.P.T., P.K., N.M.S.d.G.).

Background: Extensiveness of conduction delay and block at the pulmonary vein area (PVA) was quantified in a previous study. We hypothesized that the combination of lines of conduction block with multiple concomitantly entering sinus rhythm wavefronts at the PVA may result in increased arrhythmogenicity and susceptibility to atrial fibrillation (AF).

Methods: Intraoperative high-density epicardial mapping of PVA (N≈450 sites, interelectrode distances: 2 mm) was performed during sinus rhythm in 327 patients (241 male [74%], 67±10 [21-84] years) with and without preoperative AF. Read More

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November 2018

Impact of left atrial box surface ratio on the recurrence after ablation for persistent atrial fibrillation.

Pacing Clin Electrophysiol 2018 Dec 5. Epub 2018 Dec 5.

Department of Cardiology, Leiden University Medical Center, University of Leiden, Leiden, The Netherlands.

Background: The posterior wall of the left atrium (LA) is a well-known substrate for atrial fibrillation (AF) maintenance. Isolation of the posterior wall between the pulmonary veins (box lesion) may improve ablation success. Box lesion surface area size varies depending on the individual anatomy. Read More

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December 2018

Involvement of natriuretic peptide system in C2C12 myocytes.

Mol Cell Biochem 2018 Dec 5. Epub 2018 Dec 5.

Sohyaku Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 2-2-50, Kawagishi, Toda, Saitama, 335-8505, Japan.

The natriuretic peptide system, a key regulator of cGMP signaling, comprises three types of natriuretic peptides, osteocrin/musclin (OSTN), and their natriuretic peptide receptors. Although this system plays important roles in many organs, its physiological roles in skeletal muscle have not been clearly described. In the present study, we investigated the role of the natriuretic peptide system in C2C12 myocytes. Read More

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December 2018
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Decreased platelet-to-lymphocyte ratio as predictor of thrombogenesis in nonvalvular atrial fibrillation.

Authors:
K Zuo X Yang

Herz 2018 Dec 5. Epub 2018 Dec 5.

Heart Center & Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, 8 Gongren Tiyuchang Nanlu, Chaoyang District, 100020, Beijing, China.

Background: Inflammation plays a key role in the progression of atrial fibrillation and its related prothrombotic state. The platelet-to-lymphocyte ratio (PLR) is an easily obtainable biomarker of inflammatory burden. Decreased left atrial appendage flow velocity (LAA-FV) reflects blood stasis, and left atrial strain is a manifestation of atrial remodeling. Read More

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December 2018

Clinical Course of Dual-Chamber Implantable Cardioverter-Defibrillator Recipients followed by Cardiac Remote Monitoring: Insights from the LION Registry.

Biomed Res Int 2018 4;2018:3120480. Epub 2018 Nov 4.

Biotronik, Berlin, Germany.

Patients receiving dual-chamber implantable cardioverter-defibrillator (DR-ICD) therapy are at risk of developing atrial arrhythmia because of the increased rate of ventricular pacing and the progression of heart failure. Remote monitoring (RM) may identify the patients at highest risk of adverse events such as atrial arrhythmias. A total of 283 patients with 91,632 remote transmissions during a 15-month follow-up (FU) period enrolled in the LION registry were analysed. Read More

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November 2018
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Efficacy and Safety of Intralesional Methotrexate in the Treatment of a Large Keratoacanthoma of the Dorsal Hand in a 99-Year-Old Woman.

Case Rep Dermatol 2018 Sep-Dec;10(3):247-250. Epub 2018 Nov 14.

Medical Department, Cantabria Labs Difa Cooper, Caronno Pertusella, Italy.

Several case reports and retrospective studies have demonstrated that intralesional methotrexate (MTX) could be a very effective and safe alternative treatment of keratoacanthoma (KA). Here, we report a rapid clinical efficacy of two intralesional MTX injections (total dose 40 mg) that were performed 1 week apart in the treatment of a large KA lesion of the dorsal hand in a 99-year-old woman. The lesion, with a 3-cm major axis diameter and a thickness of 2 cm with a central ulceration had rapidly appeared on the right dorsal hand. Read More

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November 2018
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Usefulness of Exchanged Protein Directly Activated by cAMP (Epac)1-Inhibiting Therapy for Prevention of Atrial and Ventricular Arrhythmias in Mice.

Circ J 2018 Dec 6. Epub 2018 Dec 6.

Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine.

Background: It has been suggested that protein directly activated by cAMP (Epac), one of the downstream signaling molecules of β-adrenergic receptor (β-AR), may be an effective target for the treatment of arrhythmia. However, there have been no reports on the anti-arrhythmic effects or cardiac side-effects of Epac1 inhibitors in vivo. Methods and Results: In this study, the roles of Epac1 in the development of atrial and ventricular arrhythmias are examined. Read More

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December 2018

Risk Profile and 1-Year Outcome of Newly Diagnosed Atrial Fibrillation in Japan - Insights From GARFIELD-AF.

Circ J 2018 Dec 4. Epub 2018 Dec 4.

Thrombosis Research Institute.

Background: Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective non-interventional study of stroke prevention in patients with newly diagnosed non-valvular AF (NAVF) that is being conducted in 35 countries. Methods and Results: A total of 52,081 patients with a new diagnosis of NVAF were enrolled prospectively in GARFIELD-AF. Of these, 4859 (9. Read More

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December 2018

Involvement of Apelin/APJ Axis in Thrombogenesis in Valve Heart Disease Patients with Atrial Fibrillation.

Int Heart J 2018 Dec 5. Epub 2018 Dec 5.

Department of Cardiology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University.

The mechanism underlying thrombosis in atrial fibrillation (AF) is not yet clearly understood. The apelin/APJ axis parallel and counter-regulate with the angiotensin system. The present study hypothesizes that apelin/APJ axis exert its anti-thrombus effect in normal left atrial tissue and is disrupted by up-regulated renin-angiotensin-aldosterone system (RAAS) signaling during AF. Read More

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December 2018

Characteristics, Mechanism and Long-Term Ablation Outcome of Atrial Tachycardias After Mitral Valvular Surgery and Concomitant Cox-MAZE IV Procedure.

Int Heart J 2018 Dec 5. Epub 2018 Dec 5.

Department of Cardiology, Atrial Fibrillation Center, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences.

The incidence of atrial tachycardia (AT) after rheumatic mitral valvular (RMV) surgery has been well described. However, there have been few reports on the characteristics, mechanism, and long-term ablation outcome of ATs after RMV surgery and concomitant Cox-MAZE IV procedure.The present study reviewed consecutive patients who underwent AT ablation between May 2008 and July 2013. Read More

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December 2018

Cardiac Involvement in Emery-Dreifuss Muscular Dystrophy and Related Management Strategies.

Int Heart J 2018 Dec 5. Epub 2018 Dec 5.

Department of Cardiovascular Medicine, Second Xiangya Hospital of Central South University.

Emery-Dreifuss muscular dystrophy (EDMD) is a group of hereditary muscular dystrophy syndrome caused by deficiency of genes encoding nuclear envelope proteins. Patients having EDMD show the triad of muscle dystrophy, joint contracture, and cardiac disease. In almost all patients, cardiac involvement is prevalent and is the most severe aspect of EDMD. Read More

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December 2018

Atrial cardiopathy in patients with embolic strokes of unknown source and other stroke etiologies.

Neurology 2018 Dec 5. Epub 2018 Dec 5.

From the Department of Medicine (Neurology) (S.J.), Queens' University, Kingston; Departments of Medicine (Neurology) (R.R., A.P.) and Medicine (Cardiology) (A.D.J., A.W.), Toronto Western Hospital/University Health Network, and Dalla Lana School of Public Health (R.N.), University of Toronto; and Centre for Urban Health Solutions (R.N.), Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Canada.

Objective: To investigate the prevalence and clinical determinants of atrial cardiopathy in patients with embolic stroke of unknown source (ESUS) and compare with other established stroke etiologies.

Methods: In a cross-sectional study of 846 consecutive patients with ischemic stroke, we compared the prevalence of atrial cardiopathy (defined by p-wave terminal force in V1 >5,000 µV·ms or severe left atrial enlargement) between ESUS patients and patients with large artery atherosclerosis (LAA) and small vessel disease (SVD) strokes. Baseline characteristics were also compared between ESUS and cardioembolic (CE) patients. Read More

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December 2018

Atrial cardiopathy: A new cause for stroke?

Neurology 2018 Dec 5. Epub 2018 Dec 5.

From the Department of Neurology (D.L.), Weill Cornell Medical College, New York, NY; and Department of Neurology (T.R.), University of Miami Miller School of Medicine, FL.

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December 2018

Cost-effectiveness of rivaroxaban versus warfarin for treatment of nonvalvular atrial fibrillation in patients with worsening renal function.

Int J Cardiol 2018 Nov 19. Epub 2018 Nov 19.

Department of Pharmaceutical and Health Economics, School of Pharmacy, University of Southern California, Los Angeles, United States of America; Leonard D. Schaeffer Center for Health Policy and Economics, University of Southern California, Los Angeles, United States of America.

Background: Nonvalvular atrial fibrillation (NVAF) is highly prevalent and increases the risks of cardiovascular events. In a recent subgroup analysis, treatment response was shown to vary for patients exhibiting worsening renal function (WRF) on-treatment. It is important to understand the cost-effectiveness of novel oral anticoagulant (NOAC) use in this population. Read More

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November 2018

Endocardial transvenous pacing in patients with surgically palliated univentricular hearts: A review on different techniques, problems and management.

Indian Pacing Electrophysiol J 2018 Nov 30. Epub 2018 Nov 30.

Department of Pediatric Cardiology, Madras Medical Mission, Chennai, India. Electronic address:

Fontan surgery and its modifications have improved survival in various forms of univentricular hearts. A regular atrial rhythm with atrioventricular synchrony is one of the most important prerequisite for the long-term effective functioning of this preload dependent circulation. A significant proportion of these survivors need various forms of pacing for bradyarrhythmias, often due to sinus nodal dysfunction and sometimes due to atrioventricular nodal block. Read More

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November 2018

Interatrial shunting through an asymptomatic patent foramen ovale in thoracic surgery.

Ann Thorac Surg 2018 Nov 30. Epub 2018 Nov 30.

Division of Thoracic Surgery, S. Maria della Misericordia Hospital, University of Perugia Medical School, Perugia, Italy.

Background: Patent foramen ovale (PFO) is present in up to 25% of the general population and is considered an irrelevant condition in healthy subjects. Here we sought to determine an association between the presence of an asymptomatic PFO at baseline and postoperative short-term adverse events in patients undergoing major pulmonary resection for lung cancer. As well, we evaluated for the rate of PFO after pulmonary resections. Read More

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November 2018

Myocardial fibrosis predicts adverse outcome after MitraClip implantation.

Catheter Cardiovasc Interv 2018 Dec 3. Epub 2018 Dec 3.

Department of Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Heart Center, University of Amsterdam, Amsterdam, The Netherlands.

Background: High-risk patients with mitral regurgitation (MR) may be treated by a percutaneous mitral valve repair with the MitraClip, but identification of patients who may benefit remains difficult. We aimed to determine whether myocardial fibrosis predicts outcome in MR patients undergoing MitraClip implantation and is beneficial in clinical decision making.

Methods: Preprocedural to the MitraClip implantation, myocardial fibrosis was analyzed with cardiovascular magnetic resonance (CMR) through late gadolinium enhancement. Read More

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December 2018

Can postoperative massage therapy reduce pain and anxiety in cardiac surgery patients?

Interact Cardiovasc Thorac Surg 2018 Dec 1. Epub 2018 Dec 1.

Department of Vascular Surgery, Countess of Chester, Chester, UK.

A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was, 'In patients undergoing cardiac surgery, is postoperative massage therapy effective in reducing pain, anxiety and physiological parameters?'. Altogether, 287 papers were found using the reported search, of which 7 papers represented the best evidence to answer the clinical question. Read More

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December 2018
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Surgical occlusion of the left atrial appendage: it is time to adopt newer techniques!

Eur Heart J 2018 Dec;39(45):3987-3998

Department of Cardiothoracic and Vascular Surgery, German Heart Center Berlin, Berlin, Germany Department of Cardiovascular Surgery, Charite Universitätsmedizin Berlin, Berlin, Germany.

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December 2018

Frequent premature atrial contractions are associated with atrial fibrillation, brain ischaemia, and mortality: a systematic review and meta-analysis.

Europace 2018 Dec 1. Epub 2018 Dec 1.

Department of General Practice, Amsterdam UMC, University of Amsterdam, Amsterdam Public Health, Academic Medical Center, Meibergdreef 9, AZ Amsterdam, Netherlands.

Aims: Premature atrial contractions (PACs) are a common cardiac phenomenon, traditionally considered to be of little clinical significance. Recent studies, however, suggest that PACs are associated with atrial fibrillation (AF), as well as ischaemic stroke, transient ischaemic attack, and mortality. This systematic review aims to investigate the association between PACs on standard electrocardiogram (ECG) as well as PAC-count on Holter monitor and future detection of AF, brain ischaemia, and all-cause mortality in patients without a history of AF. Read More

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December 2018
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Risk stratification for stroke in atrial fibrillation: a critique.

Eur Heart J 2018 Dec 1. Epub 2018 Dec 1.

Division of Heart Rhythm Services, Department of Cardiovascular Disease, Mayo Clinic, 200 First Street SW, Rochester, MN, USA.

Despite the demonstrable success of oral anticoagulants in reducing the rate of stroke in patients with atrial fibrillation, they continue to be seriously underutilized. Indications for their use as stated in the guidelines incorporate a number of risk score algorithms, the most widely used being the CHA2DS2-VASc score. Nonetheless there are several limitations to the various scores currently in clinical use and a critique of these is the focus of this review. Read More

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December 2018

The importance of time in therapeutic range in switching from vitamin K antagonist to non-vitamin K antagonist oral anticoagulants in atrial fibrillation.

Europace 2018 Dec 1. Epub 2018 Dec 1.

Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 3, København Ø, Denmark.

Aims: Patients with non-valvular atrial fibrillation (NVAF) receiving vitamin K antagonists (VKAs) with time in therapeutic international normalized ratio (INR) range (TTR) <70%, despite good adherence, are by guidelines recommended to switch to non-VKA oral anticoagulants (NOACs). The aim was to assess if patients are switched from VKA to NOAC when TTR is <70% in a real-world setting.

Methods And Results: Non-valvular atrial fibrillation patients receiving VKA (1 January 2010 to 31 December 2012) were identified in nationwide registries. Read More

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December 2018

Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat.

J Vis Exp 2018 Nov 18(141). Epub 2018 Nov 18.

Department of Medicine, Queen's University; Department of Pediatrics, The Jikei University School of Medicine;

The mechanism of mitral stenosis-induced pulmonary venous arterialization and group 2 pulmonary hypertension (PH) is unclear. There is no rodent model of group 2 PH, due to mitral stenosis (MS), to facilitate the investigation of disease mechanisms and potential therapeutic strategies. We present a novel rat model of pulmonary venous congestion-induced pulmonary venous arterialization and group 2 PH caused by left atrial stenosis (LAS). Read More

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November 2018

How do neurologists diagnose transient ischemic attack: A systematic review.

Int J Stroke 2018 Dec 3:1747493018816430. Epub 2018 Dec 3.

1 Department of Medicine, Division of Neurology, The Ottawa Hospital, Ottawa, Canada.

Background: Identifying and treating patients with transient ischemic attack is an effective means of preventing stroke. However, making this diagnosis can be challenging, and over a third of patients referred to stroke prevention clinic are ultimately found to have alternate diagnoses.

Aims: We performed a systematic review to determine how neurologists diagnose transient ischemic attack. Read More

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December 2018
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Electrocardiographic and echocardiographic features in patients with major arterial vascular disease assigned to surgical revascularization.

Acta Cardiol 2018 Dec 3:1-7. Epub 2018 Dec 3.

a Dipartimento di Medicina Interna e Scienze Biomediche, Sezione di Cardiologia , Università degli Studi di Parma , Parma , Italy.

Background: We aimed to depict the electrocardiographic and echocardiographic aspects in patients before elective major vascular surgery.

Methods: We evaluated through standard 12 lead electrocardiography and transthoracic echocardiography 469 patients with asymptomatic large abdominal aortic aneurysm (AAA), 334 with critical carotid stenosis (CAS), and 238 with advanced peripheral artery disease (PAD) before surgical revascularization.

Results: Patients with AAA were predominantly males (p < . Read More

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December 2018

Heart filling exceeds emptying during late ventricular systole in patients with systolic heart failure and healthy subjects - a cardiac MRI study.

Clin Physiol Funct Imaging 2018 Dec 2. Epub 2018 Dec 2.

Department of Clinical Sciences, Clinical Physiology, Skane University Hospital, Lund University, Lund, Sweden.

Background: Total heart volume (THV) within the pericardium is not constant throughout the cardiac cycle and THV would intuitively be lowest at end systole. We have, however, observed a phase shift between ventricular outflow and atrial inflow which causes the minimum THV to occur before end systole. The aims were to explain the mechanism of the late-systolic net inflow to the heart and determine whether this net inflow is affected by increased cardiac output or systolic heart failure. Read More

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December 2018

The transverse and oblique sinuses of the pericardium: Anatomic and echocardiographic insights.

Echocardiography 2018 Dec 1. Epub 2018 Dec 1.

Icahn School of Medicine at Mount Sinai, New York, New York.

A number of masses and pseudomasses may be encountered during the echocardiographic examination of the transverse and oblique sinuses with significant clinical implications. This review discusses the clinically relevant anatomy of the pericardial sinuses emphasizing diagnostic pitfalls that may be encountered during their echocardiographic examination. Read More

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December 2018

Focal atrial tachycardia ablation: Highly successful with conventional mapping.

J Interv Card Electrophysiol 2018 Dec 1. Epub 2018 Dec 1.

Cardiology Department, NIMTS Hospital, Athens, Greece.

Background/objective: Radiofrequency catheter ablation (RFCA) of focal atrial tachycardia (FAT) traditionally is guided by conventional endocardial mapping of earliest atrial activation; however, more recently electro-anatomical mapping is heralded as a more effective, albeit more expensive, tool to guide ablation. Herein we present the results of conventional mapping-guided RFCA. Apropos, we conducted a literature search of studies reporting > 10 FAT patients submitted to RFCA. Read More

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December 2018
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Morbidity and mortality of synchronous hepatectomy with cytoreductive surgery/hyperthermic intraperitoneal chemotherapy (CRS/HIPEC).

J Gastrointest Oncol 2018 Oct;9(5):828-832

Department of Surgery, University of Kansas Medical Center, Kansas City, KS, USA.

Background: Liver resection in conjunction with partial colectomy for colon cancer is considered acceptable treatment for isolated metastasis to the liver. This method is unstudied in patients undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for carcinomatosis due to colon cancer and high grade appendiceal cancer.

Methods: A retrospective chart review included patients from 2005 to 2016 undergoing CRS/HIPEC. Read More

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October 2018

A review and analysis of strategies for prediction, prevention and management of post-operative atrial fibrillation after non-cardiac thoracic surgery.

J Thorac Dis 2018 Nov;10(Suppl 32):S3799-S3808

Division of Thoracic Surgery, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.

Atrial fibrillation (AF) is the most common sustained arrhythmia after non-cardiac thoracic surgery and is associated with a significant increase in perioperative morbidity, intensive care unit (ICU) admission, and mortality. Practical guidance is needed to assist clinicians in managing this critical issue and direct further research. Here we aim to provide a synoptic review and analysis of the literature to distil practical recommendations for prediction, prevention and management of post-operative atrial fibrillation (POAF) suitable for clinical application and further evaluation. Read More

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November 2018

Complexities in the Atrial Fibrillation-Stroke Relationship: Improving Comprehension of Temporal Discordance, Magnitude Synergism, and Subclinical Atrial Fibrillation -- Three Sources of Consternation for Physicians Who Care for Patients with Atrial Fibrillation.

Authors:
James A Reiffel

J Atr Fibrillation 2018 Aug 31;11(2):2100. Epub 2018 Aug 31.

Professor Emeritus of Medicine, Columbia University Dept. of Medicine, Division of Cardiology.

That clinically-documented atrial fibrillation (AF) in association with a variety of elevated clinical/laboratory risk markers is associated with an increased risk of stroke is well known -- regardless of whether the AF is paroxysmal, persistent, or permanent. Moreover, data is accumulating to suggest that the absolute rate of stroke should be expectedly higher with a greater burden of AF and greater degree of comorbid contributors. Relatedly, stroke prevention with chronic oral anticoagulation (OAC) is recommended for AF patients with appropriate risk markers by all major medical, cardiologic, and surgical guideline-writing organizations. Read More

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Assessment of DNA Damage After Ionizing Radiation Exposure in Patients Undergoing Cardiac Resynchronization Therapy Device Implantation or Atrial Fibrillation Ablation (The RADAR Study).

J Atr Fibrillation 2018 Aug 31;11(2):2094. Epub 2018 Aug 31.

Harvard Medical School, Boston, MA.

Background: There is limited data regarding effect of prolonged radiation exposure during electrophysiological (EP) procedures on direct DNA damage. Comet test has shown to assess DNA damage following radiation exposure.

Methods: We performed a single-center prospective observational study assessing direct DNA damage using the quantitative comet assay in patients undergoing cardiac resynchronization (CRT) and atrial fibrillation (AF) catheter ablation procedures. Read More

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Acute Pulmonary Vein Reconnection after Ablation using Contact-force Sensing Catheters: Incidence, Timing, and Ablation Lesion Characteristics.

J Atr Fibrillation 2018 Aug 31;11(2):2084. Epub 2018 Aug 31.

Johns Hopkins Hospital Heart and Vascular Institute, Baltimore MD.

Background: Acute pulmonary vein (PV) reconnection predicts atrial fibrillation (AF) recurrence after ablation. Contact-force (CF) sensing catheters improve lesion delivery. We assessed the incidence, timing, location, and lesion characteristics of acute reconnection after PV isolation with CF sensing catheters. Read More

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Remote Monitoring of Atrial High Rate Episodes in Pacemaker Patients. The Rapid Study Design.

J Atr Fibrillation 2018 Aug 31;11(2):2075. Epub 2018 Aug 31.

Departmental Unit of Electrophysiology, Evaluation and Treatment of Arrhythmias, Monaldi Hospital, Naples, Italy.

Background: Remote Monitoring (RM) has been introduced for several years and nowadays most pacemakers are equipped with such a technology. RM can provide early detection of high atrial rate episodes (AHREs) onset and enable prompt medical intervention. However, there are still little data on the clinical reactions triggered by the AHRE detected by RM of pacemaker recipients and on their possible benefit on patients' outcome. Read More

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"Clinical Impact of the Cryoballoon Temperature and Occlusion Status on the Success of Pulmonary Vein Isolation".

J Atr Fibrillation 2018 Aug 31;11(2):2065. Epub 2018 Aug 31.

Heart Rhythm Center, Tokyo Medical and Dental University, Tokyo.

Background: Complete occlusion of the pulmonary veins (PVs) with the cryoballoon (CB) is considered to be the crucial factor for a successful PV isolation (PVI). We investigated whether a complete occlusion was indispensable for a successful CB based PVI of every PV.

Methods And Results: Atrial fibrillation patients (n=123, 97; paroxysmal) undergoing a de novo PVI were enrolled. Read More

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Contact-Force Guided Pulmonary Vein Isolation does not Improve Success Rate in Persistent Atrial Fibrillation Patients and Severe Left Atrial Enlargement: A 12-month Follow-Up Study.

J Atr Fibrillation 2018 Aug 31;11(2):2060. Epub 2018 Aug 31.

Heart Rhythm Service, Kingston General Hospital, Queen's University, Kingston, Ontario, Canada.

Background: Catheter ablation is a cornerstone treatment strategy in atrial fibrillation (AF). Left atrial (LA) size is one of the contributors in development of AF recurrences. The impact of contact-forced (CF) guided catheter ablation on the success rate of persistent AF patients with severe enlarged LA has not been investigated yet. Read More

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Compass Mapping, Double Potentials, Activation Patterns Can Identify and Track Rotational Activity Sites in the Left Atrium of Humans with Persistent Atrial Fibrillation.

J Atr Fibrillation 2018 Aug 31;11(2):2053. Epub 2018 Aug 31.

Greenville Health System, 701 Grove Road, Greenville, SC 29605.

Background: Rotational circuits that occur between bipolar electrodes exhibit double potentials (DPs). It had been previously surmised that rotors could not be electrically tracked directly.

Purpose: Our purpose was twofold; first, to show that the use of compass mapping, one can regionally identify rotational activity; and second, to show that by combining simultaneous compass map recordings, standard narrow-adjacent bipolar, and unipolar recordings, that specific signature recording patterns emerge that allow one to identify the accurate time, location, and path of a rotational mechanism. Read More

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August 2018
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