98,074 results match your criteria Atrial Fibrillation


Left atrial disease and left atrial reverse remodeling across different stages of heart failure development and progression: a new target for prevention and treatment.

Eur J Heart Fail 2022 May 22. Epub 2022 May 22.

ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.

The left atrium is a dynamic chamber with peculiar characteristics. Stressors and disease mechanisms may deeply modify its structure and function, leading to left atrial remodeling and disease. Left atrial disease is a predictor of poor outcomes. Read More

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Recurrent heart failure hospitalizations increase the risk of mortality in heart failure patients with atrial fibrillation and type 2 diabetes mellitus in the United Kingdom: a retrospective analysis of Clinical Practice Research Datalink database.

BMC Cardiovasc Disord 2022 May 21;22(1):234. Epub 2022 May 21.

Novartis Pharma AG, 4056, Basel, Switzerland.

Background: Heart failure (HF) is a global illness and is a leading cause of hospitalizations. Recurrent HF hospitalization (HFH) is associated with increased risk of cardiovascular (CV) and all-cause mortality, thereby burdening the health system. Type 2 diabetes mellitus (T2DM) and atrial fibrillation (AF) are two important comorbidities in patients living with HF. Read More

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Mechanistic Insights into Tricuspid Regurgitation Secondary to Pulmonary Arterial Hypertension.

Am J Cardiol 2022 May 18. Epub 2022 May 18.

Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic Foundation, Cleveland, Ohio. Electronic address:

The simultaneous presence of pulmonary arterial hypertension (PAH) and secondary tricuspid regurgitation (STR) portends particularly poor outcomes. However, not all patients with PAH develop significant STR, and the mechanisms and clinical implications underlying this phenomenon remain unclear. We sought to describe the functional, anatomic, hemodynamic, and clinical characteristics of patients with PAH with and without STR. Read More

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From cryptogenic to ESUS: Toward precision medicine?

Authors:
S Timsit

Rev Neurol (Paris) 2022 May 18. Epub 2022 May 18.

Université Brest, Inserm, EFS, UMR 1078, GGB, 29200 Brest, France; Neurology and Stroke unit Department, CHRU de Brest, Inserm1078, Université de Bretagne Occidentale, 29200 Brest, France. Electronic address:

Cryptogenic infarctions are infarctions without a defined cause, despite a complete work-up. They differ from infarctions of undetermined causes, which may involve overlapping causes or an incomplete investigation. It is also different from uncommon heritable and non-heritable causes. Read More

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Full torso and limited-domain computer models for epicardial pulsed electric field ablation.

Comput Methods Programs Biomed 2022 May 13;221:106886. Epub 2022 May 13.

Electrical and Electronic Engineering, National University of Ireland Galway, Ireland; Translational Medical Device Lab, National University of Ireland Galway, Ireland.

Background And Objectives: Pulsed Electric Field (PEF) ablation has been proposed as a non-thermal energy to treat atrial fibrillation (AF) by ablation of ganglionated plexi using the epicardial approach. The electric field distribution at the target site (heart) and its surroundings has not yet been assessed previously, using epicardial ablation technique. Our objective was to develop computational models, incorporating the real anatomy of the heart and the patient's torso, to assess the electric field distribution when applying epicardial monopolar PEF. Read More

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Association between sleep disorder and atrial fibrillation: A nationwide population-based cohort study.

Sleep Med 2022 May 10;96:50-56. Epub 2022 May 10.

Taipei Heart Institute, Taipei Medical University, Taipei, Taiwan; Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:

Objectives: Sleep disorder (SD), especially sleep apnea, and its effect on atrial fibrillation (AF) are gathering attention. However, other SDs may also play an essential role in AF. The aim of the study is to investigate the effects of other SDs on the risk of atrial fibrillation development. Read More

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Effıcacy of cıtalopram on stroke recurrence: A randomızed clınıcal trıal.

J Clin Neurosci 2022 May 18;101:168-174. Epub 2022 May 18.

Ege University, Department of Administration and Statistics, İzmir, Turkey. Electronic address:

Post-stroke depression is one of the main causes of cerebrovascular and cardiovascular diseases. The aim of the present study was to investigate the efficacy of citalopram on stroke recurrence. A 52-week, randomized, double-blind, studyinvolved 440 ischemic stroke patients with depression. Read More

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Reproducibility and stability of atrial fibrillation drivers identified by an automated algorithm: CARTOFINDER.

J Interv Card Electrophysiol 2022 May 21. Epub 2022 May 21.

Department of Cardiology, Mitsubishi Kyoto Hospital, 1 Katsura Gosho-cho, Nishikyo-ku, Kyoto, 615-8087, Japan.

Background: The characteristics of atrial fibrillation (AF) drivers identified by CARTOFINDER have not been thoroughly evaluated. Therefore, the current study was sought to validate the reliability of AF drivers.

Methods: The reliability of focal and rotational activation identified by CARTOFINDER during AF was assessed by the sequential recordings in each site before and after pulmonary vein isolation (PVI) in 27 persistent AF patients. Read More

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High-power short-duration ablation index-guided pulmonary vein isolation protocol using a single catheter.

J Interv Card Electrophysiol 2022 May 20. Epub 2022 May 20.

Department of Cardiology, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland.

Background: Catheter ablation for atrial fibrillation (AF) is the most commonly performed electrophysiological procedure. To improve healthcare utilization, we aimed to compare the efficacy, efficiency, and safety of a minimalistic, streamlined single catheter ablation approach using a high-power short-duration ablation index-guided protocol (HPSD) vs. a control single-catheter protocol (SP). Read More

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The Use of Paclitaxel-Coated Devices in the Treatment of Peripheral Arterial Disease Is Not Associated with Increased Mortality or Amputations.

Ann Vasc Surg 2022 May 17. Epub 2022 May 17.

-Department of Endovascular & Vascular Surgery, Geisinger Medical Center. Electronic address:

Introduction And Objectives: Strategies for the most effective treatment for peripheral arterial disease (PAD) remain controversial among clinicians. Several trials have shown improved primary patency of femoropopliteal interventions with the utilization of paclitaxel-coated balloons or stents (DCBS) compared to conventional balloons or stents. However, a 2018 meta-analysis suggested an increased mortality risk for patients receiving DCBS, resulting in an international pause in the use of DCBS. Read More

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Frequency of cardioversions as an additional risk factor for stroke in atrial fibrillation - the FinCV-4 study.

Ann Med 2022 Dec;54(1):1452-1458

Heart Center, Turku University Hospital and University of Turku, Turku, Finland.

Background: Patients with atrial fibrillation (AF) are selected for oral anticoagulation based on individual patient characteristics. There is little information on how clinical AF burden associates with the risk of ischaemic stroke or systemic embolism (SSE). The aim of this study was to explore the association of the frequency of cardioversions (CV) as a measure of clinical AF burden on the long-term SSE risk, with a focus on patients at intermediate stroke risk based on CHADS-VASc score. Read More

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December 2022

Resting heart rate and incident atrial fibrillation: A stratified Mendelian randomization in the AFGen consortium.

PLoS One 2022 20;17(5):e0268768. Epub 2022 May 20.

Institute of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.

Background: Both elevated and low resting heart rates are associated with atrial fibrillation (AF), suggesting a U-shaped relationship. However, evidence for a U-shaped causal association between genetically-determined resting heart rate and incident AF is limited. We investigated potential directional changes of the causal association between genetically-determined resting heart rate and incident AF. Read More

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Long-term metabolic fate and mortality in obesity without metabolic syndrome.

Ann Med 2022 Dec;54(1):1432-1443

Research Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital, University of Oulu, Oulu, Finland.

Background: Obesity and metabolic syndrome (MetS) are known to expose to atrial fibrillation (AF), cardiovascular diseases (CVD) and mortality. Metabolically healthy obesity refers to obesity without MetS. This study aimed to investigate how obesity and MetS modify the risk of CVD, AF and mortality in very long-time follow-up. Read More

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December 2022

Major adverse cardiovascular events in bulgarian patients with chronic coronary syndrome.

Niger J Clin Pract 2022 May;25(5):710-717

Department of Cardiology, Medical University, University Hospital Alexandrovska, Clinic of Propedeutics of Internal Diseases, Sofia, Bulgaria.

Background: In primary prevention, most guidelines rely on atherosclerotic cardiovascular disease risk assessment to determine the appropriateness and intensity of risk factor modification.

Aims: This study aimed to analyze the prognostic role of risk factors, comorbidities, and coronary artery calcium score (CACS) for major adverse cardiovascular events (MACEs) in Bulgarian patients with chronic coronary syndrome. An observational study conducted in a cardiology department. Read More

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Relationship of diabetes, heart failure, and N-terminal pro-B-type natriuretic peptide with cardiovascular outcomes in patients with atrial fibrillation.

ESC Heart Fail 2022 May 20. Epub 2022 May 20.

Division of Cardiology, Medical University of Vienna, Vienna, Austria.

Aims: We aim to explore the relationship of heart failure (HF) and diabetes with cardiovascular (CV) death or hospitalization for HF (HHF) and to study the clinical utility of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in an unselected patient population with atrial fibrillation (AF).

Methods And Results: Patients with AF admitted to a tertiary academic center between January 2005 and July 2019 were identified through a search of electronic health records. We used Cox regression models adjusted for age, sex, estimated glomerular filtration rate, diabetes, HF, body mass index, prior myocardial infarction, coronary artery disease, hypertension, smoking, C-reactive protein, and low-density lipoprotein cholesterol. Read More

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Population pharmacokinetic models for direct oral anticoagulants: a systematic review and clinical appraisal using exposure simulation.

Clin Pharmacol Ther 2022 May 20. Epub 2022 May 20.

Division of General Internal Medicine, Geneva University Hospitals, Geneva, Switzerland.

Available data has shown an association between direct oral anticoagulant (DOAC) plasma concentration and clinical, particularly bleeding, events. Factors that may influence DOAC plasma concentration are therefore the focus of particular attention. Population pharmacokinetic (POPPK) analyses can help in identifying such factors while providing predictive models. Read More

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Stereotactic Radiotherapy Ablation and Atrial Fibrillation: Technical Issues and Clinical Expectations Derived From a Systematic Review.

Front Cardiovasc Med 2022 3;9:849201. Epub 2022 May 3.

Department of Clinical Electrophysiology and Cardiac Pacing, Centro Cardiologico Monzino IRCCS, Milan, Italy.

Aim: The purpose of this study is to collect available evidence on the feasibility and efficacy of stereotactic arrhythmia radio ablation (STAR), including both photon radiotherapy (XRT) and particle beam therapy (PBT), in the treatment of atrial fibrillation (AF), and to provide cardiologists and radiation oncologists with a practical overview on this topic.

Methods: Three hundred and thirty-five articles were identified up to November 2021 according to preferred reporting items for systematic reviews and meta-analyses criteria; preclinical and clinical studies were included without data restrictions or language limitations. Selected works were analyzed for comparing target selection, treatment plan details, and the accelerator employed, addressing workup modalities, acute and long-term side-effects, and efficacy, defined either by the presence of scar or by the absence of AF recurrence. Read More

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Pasteurella multocida Bacteremia Secondary to Peritoneal Dialysis Associated Peritonitis: A Case Report and Literature Review.

Cureus 2022 Apr 16;14(4):e24188. Epub 2022 Apr 16.

Division of Infectious Diseases and Geographic Medicine, University of Texas Southwestern Medical Center, Dallas, USA.

We report the fiftieth case in the literature of species peritoneal dialysis (PD)-related peritonitis and the third reported case of bacteremia associated with PD-related peritonitis. Our review provides the most up-to-date collection of all fifty reported cases of PD-related peritonitis caused by  species. A 77-year-old Caucasian male with a past medical history significant for new-onset left-ventricular systolic heart failure, severe mitral valve regurgitation, and end-stage renal disease on PD for six months presented to the emergency department with a one-week cloudy peritoneal effluent and intermittent abdominal pain. Read More

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Electrocardiogram Biometrics Using Transformer's Self-Attention Mechanism for Sequence Pair Feature Extractor and Flexible Enrollment Scope Identification.

Sensors (Basel) 2022 Apr 30;22(9). Epub 2022 Apr 30.

School of Electrical and Electronic Engineering, USM Engineering Campus, Universiti Sains Malaysia, Nibong Tebal 14300, Malaysia.

The existing electrocardiogram (ECG) biometrics do not perform well when ECG changes after the enrollment phase because the feature extraction is not able to relate ECG collected during enrollment and ECG collected during classification. In this research, we propose the sequence pair feature extractor, inspired by Bidirectional Encoder Representations from Transformers (BERT)'s sentence pair task, to obtain a dynamic representation of a pair of ECGs. We also propose using the self-attention mechanism of the transformer to draw an inter-identity relationship when performing ECG identification tasks. Read More

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Canagliflozin and Atrial Fibrillation in Type 2 Diabetes Mellitus: A secondary analysis from the CANVAS Program and CREDENCE trials and meta-analysis.

Diabetes Obes Metab 2022 May 19. Epub 2022 May 19.

The George Institute for Global Health, UNSW Sydney, Sydney, Australia.

Aims: The effect of sodium-glucose co-transporter 2 inhibitors on atrial fibrillation/flutter (AF/AFL) is unclear. We assessed the effects of canagliflozin on the incidence of AF/AFL and other key cardiorenal outcomes in a pooled analysis of the CANVAS and CREDENCE trials.

Materials And Methods: Participants with T2D and high risk of cardiovascular disease or chronic kidney disease were included and randomly assigned to canagliflozin or placebo. Read More

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Catheter Ablation for Atrial Fibrillation in the Elderly > 75 Years old: Systematic Review and Meta-Analysis.

J Cardiovasc Electrophysiol 2022 May 19. Epub 2022 May 19.

Division of Cardiovascular Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.

Introduction: Atrial fibrillation (AF) ablation is increasingly performed worldwide. As comfort with AF ablation increases, the procedure is increasingly used in patients that are older and in those with more comorbidities. However, it is not well established whether AF ablation in the elderly, especially those >75 years old, has comparable safety and efficacy to younger populations. Read More

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The wall of unintended consequences: is the main benefit of posterior LA wall isolation simply more durable pulmonary vein isolation?

Authors:
Paul C Zei

J Cardiovasc Electrophysiol 2022 May 19. Epub 2022 May 19.

Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Medicine is rife with therapies originally developed for a specific purpose, yet after some time, the true benefit is determined to lie elsewhere - examples of the "law of unintended consequences". This article is protected by copyright. All rights reserved. Read More

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Incidence and predictors of cardiac arrhythmias in patients with COVID-19 induced ARDS.

J Cardiol 2022 May 16. Epub 2022 May 16.

Department of Cardiology II - Electrophysiology, University Hospital Muenster, Albert-Schweitzer-Campus 1, Muenster, Germany.

Introduction: Recent studies suggest cardiac involvement with an increased incidence of arrhythmias in the setting of coronavirus disease 2019 (COVID-19). The aim of this study was to evaluate the risk of potentially lethal arrhythmias and atrial fibrillation in patients with COVID-19-induced acute respiratory distress syndrome (ARDS) and to elicit possible predictors of arrhythmia occurrence.

Methods And Results: A total of 107 patients (82 male, mean age 60 ± 12 years, median body mass index 28 kg/m) treated for COVID-19-induced ARDS in a large tertiary university hospital intensive care unit between March 2020 and February 2021 were retrospectively analyzed. Read More

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Increased Risk of Cardio-Cerebrovascular Diseases in Migraine Patients: A Nationwide Population-Based, Longitudinal Follow-Up Study in South Korea.

J Clin Neurol 2022 May;18(3):323-333

Department of Data Science, Hanmi Pharm. Co., Ltd., Seoul, Korea.

Background And Purpose: Migraine is reportedly associated with several cardio-cerebrovascular diseases (CCDs), but some of these diseases have not received sufficient attention. We thus attempted to determine the associations of migraine with peripheral arterial disease (PAD), ischemic heart disease (IHD), atrial fibrillation/flutter (AF), ischemic stroke (IS), and hemorrhagic stroke (HS).

Methods: The study population was recruited by applying International Classification of Diseases, Tenth Revision (ICD-10) codes to the database of the Korean National Health Insurance Service from 2002 to 2018. Read More

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Population-Level Impact of the Guidelines Update on Patient Selection and Outcomes After Cardiac Resynchronization Therapy.

JACC Clin Electrophysiol 2022 May 30;8(5):651-661. Epub 2022 Mar 30.

Center for Arrhythmia Care, Heart and Vascular Institute, The University of Chicago Pritzker School of Medicine, Chicago, Illinois, USA. Electronic address:

Objectives: This study sought to analyze the impact of the American College of Cardiology, American Heart Association, and Heart Rhythm Society (ACC/AHA/HRS) guidelines for cardiac resynchronization therapy with defibrillator (CRT-D) update on utilization and efficacy of CRT-D.

Background: In September 2012, the ACC/AHA/HRS guidelines for CRT-D were modified to include left bundle branch block (LBBB) as a Class I indication.

Methods: The IBM Watson MarketScan Database was queried between January 1, 2003, and December 31, 2018, for CRT-D implants or upgrades. Read More

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Evidence to Support Rhythm Control Is Superior to Rate Control as Treatment for Atrial Fibrillation.

JACC Clin Electrophysiol 2022 May;8(5):633-634

Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Electronic address:

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Age and Outcomes of Early Rhythm Control in Patients With Atrial Fibrillation: Nationwide Cohort Study.

JACC Clin Electrophysiol 2022 May;8(5):619-632

Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address:

Objectives: This study sought to investigate whether the effects of early rhythm control differ according to age.

Background: Rhythm control, compared with usual care among patients recently diagnosed with atrial fibrillation (AF), was found to be associated with a lower risk of adverse cardiovascular outcomes. It is unclear whether the results can be generalized for older adults. Read More

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Adjunctive Left Atrial Posterior Wall Isolation in Treating Atrial Fibrillation: Insight From a Large Secondary Analysis.

JACC Clin Electrophysiol 2022 May 30;8(5):605-618. Epub 2022 Mar 30.

Department of Cardiology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China; Cardioangiologisches Centrum Bethanien, Kardiologie, Medizinische Klinik III, Agaplesion Markus Krankenhaus, Akademisches Lehrkrankenhaus der Goethe-Universität Frankfurt am Main, Frankfurt am Main, Germany; Cardioangiologisches Centrum Bethanien (CCB), Kardiologie, Medizinische Klinik III, Agaplesion Markus Krankenhaus, Akademisches Lehrkrankenhaus der Goethe-Universität Frankfurt am Main, Frankfurt am Main, Germany; Die Sektion Medizin, Universität zu Lübeck, Lübeck, Germany. Electronic address:

Objectives: This study evaluated the role of adjunctive left atrium posterior wall isolation (PWI) in preventing atrial fibrillation (AF) recurrence.

Background: The left atrium posterior wall is an arrhythmogenic substrate that contributes to the development of AF.

Methods: This was an updated pooled analysis that included clinical data regarding PWI plus pulmonary vein isolation (PVI) in treating AF. Read More

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Local Impedance Drop Predicts Durable Conduction Block in Patients With Paroxysmal Atrial Fibrillation.

JACC Clin Electrophysiol 2022 May 23;8(5):595-604. Epub 2022 Feb 23.

Department of Cardiology, Freeman Hospital, Newcastle Upon Tyne, United Kingdom.

Objectives: This analysis was performed to evaluate the transition of local impedance (LI) drop during pulmonary vein isolation (PVI) to durable block and mature lesion formation based on 3-month mapping procedures.

Background: A radiofrequency catheter measuring LI has been shown to be effective for performing PVI in patients with paroxysmal atrial fibrillation. Previous analysis has demonstrated LI drop to be predictive of pulmonary vein segment conduction block during an atrial fibrillation ablation procedure. Read More

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