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J Dtsch Dermatol Ges 2019 Feb;17(2):158-166

University of Groningen, University Medical Center Groningen, Department of Dermatology, The Netherlands.

Background And Objectives: Studies of beekeepers have mostly focused on contact allergy to propolis. The overall prevalence of hand eczema (HE) in beekeepers has not been studied. Our objectives were to gain insight into the prevalence of HE in the Dutch beekeeper population; to define the impact of beekeeping activities on HE and vice versa; and to determine associated factors. Read More

Eur J Dermatol 2019 Feb 11. Epub 2019 Feb 11.

Department of Dermatology, Hospital de Santo António dos Capuchos.

J Oleo Sci 2019 Feb 13. Epub 2019 Feb 13.

Department of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University.

Bacterial flora on the skin surface contains Staphylococcus aureus (S. aureus) and Staphylococcus epidermidis (S. epidermidis) which causes rough skin and atopic dermatitis and enhances innate immunity, respectively. Read More

Protein Pept Lett 2019 Feb 12. Epub 2019 Feb 12.

The Graduate School, bCollege of Science, University of Santo Tomas, España Boulevard, Sampaloc 1015, Manila. Philippines.

The house dust mite Suidasia pontifica (Sp) is an important source of allergens in tropical regions that trigger IgE-mediated allergic reactions such as allergic asthma, atopic dermatitis and allergic rhinitis. Detection of Sp-specific proteins are important in the management and prevention of allergic diseases. The study aimed to provide a proof of concept for a gold nanoparticle-labeled sandwich format lateral flow immunoassay (LFIA) kit for the detection of Sp-specific proteins. Read More

Vaccines (Basel) 2019 Feb 12;7(1). Epub 2019 Feb 12.

University of Dundee, Medical School, Department of Molecular and Clinical Medicine, Jacqui Woods Centre, Ninewells Hospital, Ninewells Drive, Dundee DD1 9SY, UK.

Background: The development of therapeutic vaccines requires thorough knowledge of potential hazards associated with long-term inactivation of self-proteins. Among potential targets, interleukin 13 (IL-13) merits consideration, as monoclonal antibodies disrupting IL-13 signaling are proving to be exceedingly effective in common conditions such as atopic dermatitis.

Objective: Given the mass publication of scientific data, an appraisal of safety aspects is challenging. Read More

Dermatology 2019 Feb 13:1-7. Epub 2019 Feb 13.

Department of Dermato-Venereology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.

Background: Treatment of atopic dermatitis (AD) may be challenging, therefore some patients seek complementary and alternative medications (CAM). We determined prevalence and predictors for CAM use in a hospital cohort of AD patients.

Material And Methods: Between January 1, 2012, and December 31, 2017, AD patients referred to the dermatological outpatient clinic at Bispebjerg Hospital were included in the study. Read More

Br J Dermatol 2019 Feb 13. Epub 2019 Feb 13.

Regeneron Pharmaceuticals, Inc, Tarrytown, NY, U.S.A.

Background: Atopic dermatitis (AD) is a heterogeneous disease with a multifactorial aetiology and complex pathophysiology. This heterogeneity translates into different trajectories of disease progression with respect to severity, persistence, and risk of development of atopic comorbidities. Determining which possible disease trajectories or comorbidities any individual child might develop is challenging in clinical practice. Read More

J Bras Pneumol 2019 Feb 11;45(1):e20170431. Epub 2019 Feb 11.

. Departamento de Medicina e Enfermagem, Universidade Federal de Viçosa, Viçosa (MG) Brasil.

Objective: To determine the prevalence of vitamin D deficiency/insufficiency in children 0-18 years of age with recurrent wheezing and/or asthma residing in the microregion of Viçosa, Minas Gerais, Brazil, and treated at a referral center, and to determine its association with major risk factors for wheezing.

Methods: A cross-sectional study was performed using a semi-structured questionnaire, which was administered by trained interviewers to the legal guardians of the study participants. Data were obtained regarding general characteristics of recurrent wheezing; general sociodemographic, environmental, and biologic factors; and atopy-related factors. Read More

Cutis 2019 Jan;103(1):26;27;28;29;30;E2;E3;E4

Departments of Dermatology and Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Warts are superficial viral infections of the skin that are extremely common in children. The infection usually lasts more than 1 year and can be moderately contagious in specific settings; for instance, warts are particularly common and spread more easily in the setting of atopic dermatitis, a chronic, itchy pediatric skin condition caused by barrier and immune defects. Therapies for pediatric warts are characterized according to 6 major categories: destructive; immune stimulating; immune modulating, including normalization of epithelial growth; vascular destructive; irritant; and nitric oxide releasing. Read More

Cutis 2019 Jan;103(1):46-50

San Diego Family Dermatology, National City, California; Family Health Center of San Diego, California; Scripps Mercy Hospital Chula Vista, California; and the College of Osteopathic Medicine, Touro University California, Vallejo, USA.

Pityriasis amiantacea (PA) is a hair disorder characterized by matting of multiple hair shafts, typically occurring as an idiopathic condition. A 67-year-old woman with multiple myeloma who developed PA following a bone marrow transplant with melphalan conditioning is described.She noted initial changes in scalp hair regrowth 4 weeks posttransplant. Read More

J Dermatol 2019 Feb 13. Epub 2019 Feb 13.

Sanofi K.K., Tokyo, Japan.

Moderate to severe atopic dermatitis (AD) has a high disease burden and a significant effect on quality of life. Observational studies are necessary to determine the patient disease burden and long-term disease control in the Japanese population. ADDRESS-J is a non-interventional, observational registry of adult Japanese patients with moderate to severe AD. Read More

Drug Saf Case Rep 2019 Feb 12;6(1). Epub 2019 Feb 12.

Juntendo University School of Medicine, Tokyo, Japan.

A 24-year-old woman with atopic dermatitis and persistent fever (axillary temperature of 37-38 °C for 6 months) received combination ophthalmic drops containing tropicamide and phenylephrine (Mydrin-P), which exacerbated her fever within 15 min after instillation. Her axillary fever reached 40.1 °C but resolved the following day. Read More

Mol Med Rep 2019 Jan 22. Epub 2019 Jan 22.

Department of Companion and Laboratory Animal Science, Kongju National University, Yesan, Chungcheongnam 32439, Republic of Korea.

Dendropanax morbifera (D. morbifera), known as Dendro, means 'omnipotent drug' (Panax), and has been called the panacea tree. Various studies on D. Read More

Endocr Metab Immune Disord Drug Targets 2019 Feb 11. Epub 2019 Feb 11.

Department of Biomedical Science and Human Oncology, Dermatological Clinic, University of Bari, IT-70124 Bari. Italy.

Backgound: The relationship between atopic dermatitis and allergic contact dermatitis is frequently debated, particularly in children. The impaired skin barrier of atopic subjects can facilitate the penetration of exogenous agents and its mutations in filaggrin gene might be implicated in an increased risk to develop contact dermatitis. Moreover, atopic children are protractedly exposed to chemical substances contained in skincare products from an early age. Read More

Open Access Maced J Med Sci 2019 Jan 20;7(2):243-246. Epub 2019 Jan 20.

University of Rome G. Marconi, Rome, Italy.

Background: Atopic dermatitis (AD) is a common, chronic, relapsing, genetically determined inflammatory skin disorder. Staphylococcus aureus (S. aureus) plays an important role in the pathogenesis of AD. Read More

Open Access Maced J Med Sci 2019 Jan 23;7(2):204-207. Epub 2019 Jan 23.

University of Rome G. Marconi, Rome, Italy.

Background: Hand eczema is a common chronic and relapsing skin disease with various clinical features. Hand eczema aetiology can be allergic contact dermatitis (ACD), irritant contact dermatitis (ICD), atopic dermatitis (AD) and unknown or combination causes. If the causative agents are not detected treatment of hand eczema will be a failure. Read More

Open Access Maced J Med Sci 2019 Jan 27;7(2):181-183. Epub 2019 Jan 27.

University of Rome G. Marconi, Rome, Italy.

Background: Infected eczema is one of the most common complications of eczema. The progression and treatment of infected eczema have become more complex and difficulty due to the antibiotic resistance of bacteria and the abuse of antibiotics in treatment.

Aim: Our research was conducted with the aim of investigating the severity of in vitro antibiotic resistance in patients with bacterially infected eczema at Ho Chi Minh City Hospital of Dermatology. Read More

Indian J Dermatol 2019 Jan-Feb;64(1):34-40

Department of Clinical Immunology and Allergy, Faculty Hospital and Medical Faculty of Charles University, Hradec Králové, Czech Republic.

Background: Eosinophils play an important pathogenic role in atopic dermatitis (AD), but its exact function remains to be determined.

Aims And Objectives: The aim of this study was to correlate the eosinophil count with the manifestations such as asthma bronchiale, rhinitis, level of total IgE, sensitization to mites, animal dander, bird feather, dust, mixture of grass, mixture of trees, mixture of fungi, duration of lesions (persistent or occasional during last year), family history about atopy, and onset of AD (under or above 5 year of age).

Materials And Methods: Two hundred and seventy-two patients suffering from AD at the age of 14 year or older were examined - 100 men and 172 women with the average age of 26. Read More

Int Immunopharmacol 2019 Feb 8;69:263-269. Epub 2019 Feb 8.

Department of Dermatology, Third Xiangya Hospital of Central South University, Changsha, Hunan 41006, China. Electronic address:

Atopic dermatitis (AD) is a chronic, non-contagious, inflammatory skin disorder characterized by relapsing eczematous lesions. Its pathogenesis remains incompletely understood. The current evidence has emerged to show that skin and gut microbiome play critical roles in the pathogenesis and progression of AD. Read More

Allergy 2019 Feb 11. Epub 2019 Feb 11.

Department of Microbiology, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.

Asia Pac Allergy 2019 Jan 22;9(1):e7. Epub 2019 Jan 22.

University of Manchester, Manchester, UK.

Childhood asthma is one condition within a family of allergic diseases, which includes allergic rhinitis, atopic dermatitis, and food allergy, among others. Omalizumab is an anti-IgE antibody therapy that was approved in Japan for children with asthma and added to the Japanese pediatric asthma guidelines in 2017. This review highlights the Japanese clinical perspectives in pediatric allergic asthma, and consideration for allergic comorbidities, and reflects on omalizumab clinical trials in progress to present comprehensive future opportunities. Read More

Asia Pac Allergy 2019 Jan 21;9(1):e5. Epub 2019 Jan 21.

Allergy Center, National Center for Child Health and Development, Tokyo, Japan.

Background: Previous studies have reported that exposure to paraben (Pb) and triclosan (TCS) is associated with allergies. However, Pb and TCS exposure in the Japanese population is not fully understood.

Objectives: The present study was aimed to examine such exposure among Japanese individuals with allergic diseases. Read More

Int Arch Allergy Immunol 2019 Feb 8:1-12. Epub 2019 Feb 8.

Institute of Pharmacology, University of Bern, Bern, Switzerland.

Atopic dermatitis (AD) is a chronic inflammatory skin disease presenting with recurrent eczematous lesions and intense pruritus. It is common and affects both children and adults, often beginning in infancy. Due to the unpredictable disease course, its visible skin lesions, itching and scratching followed by sleeplessness, other associated atopic diseases, and behavioral and psychiatric disorders, AD is an immense burden for patients and caregivers. Read More

J Dairy Sci 2019 Feb 6. Epub 2019 Feb 6.

Department of Microbiology, College of Medicine, Chung-Ang University, Seoul 06974, Republic of Korea. Electronic address:

Atopic dermatitis (AD) causes chronic inflammatory skin disease that results in a considerable economic expense and social burden. Certain Lactobacillus strains ameliorate AD, but the effects of probiotic yeast on AD have not been investigated to date. In this study, we isolated Kazachstania turicensis CAU Y1706, commonly known as a kefir yeast, and evaluated its mitigating effects using an ovalbumin-sensitized AD mouse model. Read More

J Allergy Clin Immunol 2019 Feb 6. Epub 2019 Feb 6.

Glenmark Pharmaceuticals, Inc, Paramus, NJ, USA.

Background: GBR 830 is a humanized, monoclonal antibody against OX40, a co-stimulatory receptor on activated T-cells. OX40 inhibition may have a therapeutic role in T-cell-mediated diseases, including atopic dermatitis (AD).

Objective: This exploratory phase 2a study investigated safety, efficacy, and tissue effects of GBR 830 in AD. Read More

J Invest Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland. Electronic address:

IL-17E (IL-25) is a member of the IL-17 cytokine family involved in the promotion of type 2 immune responses. Recently, IL-17E has been reported to be upregulated in distinct skin inflammatory diseases such as psoriasis, atopic and contact dermatitis. We assessed the role played by IL-17E in skin inflammation. Read More

J Invest Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea. Electronic address:

Adipokines modulate immune responses and lipid metabolism in allergic disease; however, little is known about its role in the skin barrier and atopic dermatitis (AD). We identified zinc-alpha-2 glycoprotein (ZAG), an adipokine that regulates lipid mobilization, as a biomarker for AD. ZAG levels were consistently decreased in sera, T cells, and skin in human AD patients compared with healthy controls. Read More

Br J Dermatol 2019 Feb 9. Epub 2019 Feb 9.

Department of Dermatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.

Background: Alterations of the skin microbiome have been associated with atopic dermatitis (AD) and its severity. The nasal microbiome in relation to AD severity is less well studied.

Objective: We aimed to characterize the nasal and skin microbiome in children with AD in relation to disease severity. Read More

Wiad Lek 2018 ;71(9):1774-1776

Department Of Psychiatry In Tarnowskie Gory, School Of Medicine With The Division Of Dentistry In Zabrze, Medical University Of Silesia, Zabrze, Polska.

According to "holistic" model of physician's approach to the patient, physical, psychological and social aspects should be taken into account when we assess disease and effects of diagnostics and treatment. Those attributes form health related quality of life. Patient's disposition to disease depends on many psychological factors, among them sense of coherence (SOC). Read More

Int J Mol Sci 2019 Feb 7;20(3). Epub 2019 Feb 7.

Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea.

As the outermost layer of the body, the skin harbors innumerable and varied microorganisms. These microorganisms interact with the host, and these interactions contribute to host immunity. One of the most abundant genera of skin commensals is . Read More

Pediatr Allergy Immunol 2019 Feb 8. Epub 2019 Feb 8.

University Children's Hospital Zurich, Switzerland.

Background: Allergies are a serious public health issue and prevalences are rising worldwide. The role of antibiotics in the development of allergies has repeatedly been discussed, as results remain inconsistent. The aim of this study was to investigate the association between pre- & postnatal antibiotic exposure and subsequent development of allergies (atopic dermatitis, food allergy, asthma, atopic sensitization and allergic rhinitis). Read More

Acta Derm Venereol 2019 02 8. Epub 2019 Feb 8.

Royal Randwick Medical Centre, 70/73-115 Belmore Road, Randwick NSW 203, Australia.

Concerns about topical steroid withdrawal are causing some patients to cease long-term topical corticosteroid therapy, however, little is known about the ensuing clinical outcomes. This qualitative case series studied 10 children whose parents stopped their chronic topical corticosteroid use and subsequently developed features typically reported in adults experiencing topical steroid withdrawal. Patients were seen in an Australian general practice between April 2014 and October 2018, with follow-up periods ranging from 18 months to 4 years. Read More

Ophthalmic Plast Reconstr Surg 2019 Feb 4. Epub 2019 Feb 4.

Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Medical Center, New York, New York, U.S.A.

Purpose: To study the effect of periocular steroid use on intraocular pressure (IOP).

Methods: Charts of adult patients with atopic dermatitis or eczema treated with topical periocular steroid creams and ointments from January 1st, 2007 to October 1st, 2017 were reviewed. Patients with the following were excluded: glaucoma, ocular hypertension, known systemic/topical/injectable steroid history, and lack of documented IOP prior to or during treatment with periocular steroid ointment. Read More

Br J Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Regeneron Pharmaceuticals, Tarrytown, NY, U.S.A.

Background: Moderate-to-severe atopic dermatitis (AD) is a chronic disease characterised by intense, persistent, and debilitating itch, resulting in sleep deprivation, signs of anxiety and depression, impaired quality of life and reduced productivity. The Peak Pruritus Numerical Rating Scale (NRS) was developed and validated as a single-item, patient-reported outcome (PRO) of itch severity.

Objectives: To describe the content validity and psychometric assessment (test-retest reliability, construct validity, known-groups validity, sensitivity to change) of the Peak Pruritus NRS, and to empirically derive a responder definition to identify adults with a meaningful change in itch. Read More

Inflammation 2019 Feb 7. Epub 2019 Feb 7.

Department of Molecular Medicine and TIDRC, School of Medicine, Ewha Womans University, Seoul, 07084, South Korea.

This experiment was conducted to investigate the effects of a benzylideneacetophenone derivative ((2E)-3-(4-hydroxy-3-methoxyphenyl)phenylpro-2-en-l-one (JC3)) on trimellitic anhydride (TMA)-induced atopic dermatitis (AD)-like symptoms in mice. To induce AD, the dorsal skins of mice were treated with 5% TMA on day 0 and both ears were treated with 5% TMA on day 5 and with 2% TMA from day 6 to day 14. JC3 (1, 5, 10 mg/kg, i. Read More

Clin Transl Allergy 2019 31;9. Epub 2019 Jan 31.

2Department of Clinical Science and Education, Karolinska Institutet, and Sachs' Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden.

Background: Atopic dermatitis (AD) is a complex heterogeneous chronic inflammatory skin disease. Specific IgE antibodies against autoantigens have been observed in a subgroup of AD patients, however, little is known about IgG-auto-reactivity in AD. To investigate the presence of autoreactive IgG antibodies, we performed autoantibody profiling of IgG in patients with AD of different severities and in healthy controls (HC). Read More

J Enzyme Inhib Med Chem 2019 Dec;34(1):613-619

f College of Pharmacy , Keimyung University , Daegu , Republic of Korea.

This study aimed to evaluate the effects of cinnamamides on atopic dermatitis (AD) and the mechanisms underlying these effects. To this end, the actions of two cinnamamides, (E)-3-(4-hydroxyphenyl)-N-phenylethyl acrylamide (NCT) and N-trans-coumaroyltyramine (NCPA), were determined on AD by orally administering them to mice. Oral administration of the cinnamamides ameliorated the increase in epidermal and dermal thickness as well as mast cell infiltration. Read More

Dermatology 2019 Feb 6:1-2. Epub 2019 Feb 6.

Department of Dermatology, Tufts Medical Center, Boston, Massachusetts,

Rev Chil Pediatr 2018 Dec;89(6):718-725

Departamento de Cardiología Pediátrica y Enfermedades Respiratorias del Niño, División de Pediatría, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Objectives: To describe the prevalence of sleep-disordered breathing (SDB) in Chilean schoolchil dren and study associated risk factors.

Patients And Method: We carried out a transversal and des criptive study. Questionnaires were sent to the parents of children attending first year of elementary school in the Metropolitan Region (Santiago), the Biobío Region (Concepción, Chillán, Yumbel) and the Magallanes Region (Porvenir and Puerto Natales). Read More

Immunopharmacol Immunotoxicol 2019 Feb 6:1-8. Epub 2019 Feb 6.

a School of Life Science and Biopharmaceutics , Shenyang Pharmaceutical University , Shenyang , China.

Background: Dehydroxymethylepoxyquinomicin (DHMEQ) is a specific and potent inhibitor of nuclear factor-kappa B (NF-κB) and has been shown to possess promising potential as an anti-inflammation including anti-atopic dermatitis (AD)-like skin lesions.

Objective: To further evaluate the activity of DHMEQ in vivo modified AD-like lesion model in BALB/c mice and in vitro AD-like lesion cell model in human keratinocytes.

Materials And Methods: In this study, in vivo modified AD-like lesion model in BALB/c mice was chronically induced by the repetitive and alternative application of 2,4-dinitrochlorobenzene (DNCB) and oxazolone (OX) on ears, and stratum corneum of the ear skin was additionally stripped off with surgical tapes before each challenge with DNCB/OX. Read More

Acta Derm Venereol 2019 Feb 6. Epub 2019 Feb 6.

Department of Dermatology, University Hospital, FR-25000 Besançon, France.

Adv Nutr 2019 Jan;10(suppl_1):S49-S66

Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, Armilla, Granada, Spain.

Probiotics are living microorganisms that confer health benefits to the host when administered in adequate amounts; however, dead bacteria and their components can also exhibit probiotic properties. Bifidobacterium and strains of lactic acid bacteria are the most widely used bacteria that exhibit probiotic properties and are included in many functional foods and dietary supplements. Probiotics have been shown to prevent and ameliorate the course of digestive disorders such as acute, nosocomial, and antibiotic-associated diarrhea; allergic disorders such as atopic dermatitis (eczema) and allergic rhinitis in infants; and Clostridium difficile-associated diarrhea and some inflammatory bowel disorders in adults. Read More

J Eur Acad Dermatol Venereol 2019 Feb 5. Epub 2019 Feb 5.

Centre of Evidence Based Dermatology, University of Nottingham, Nottingham, UK.

Background: Atopic eczema (also known as eczema) is a chronic, inflammatory skin condition that often afflicts patients' health and wellbeing. The Harmonising Outcome Measures for Eczema (HOME) initiative recommends that "long-term control of eczema" is measured in all clinical trials 3 months or longer in duration. However, little has been published on what eczema control means to those living with or treating atopic eczema. Read More

Mol Carcinog 2019 Feb 5. Epub 2019 Feb 5.

Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama-shi, Okayama 700-8558, Japan.

Compiling evidence indicates an unusual role of extracellular S100A8/A9 in cancer metastasis. S100A8/A9 secreted from either cancer cells or normal cells including epithelial and inflammatory cells stimulates cancer cells through S100A8/A9 sensor receptors in an autocrine or paracrine manner, leading to cancer cell metastatic progression. We previously reported a novel S100A8/A9 receptor, neuroplastin-β (NPTNβ), which plays a critical role in atopic dermatitis when it is highly activated in keratinocytes by an excess amount of extracellular S100A8/A9 in the inflammatory skin lesion. Read More

Indian J Dermatol Venereol Leprol 2019 Mar-Apr;85(2):195-196

Department of Clinical Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Br J Dermatol 2019 Feb 4. Epub 2019 Feb 4.

Unit for Population-Based Dermatology Research, St John's Institute of Dermatology, Guy's& St Thomas' NHS Foundation Trust and King's College London, London, UK.

Background: Comparative, real-life and long-term evidence on the effectiveness and safety of photo- and systemic therapy in moderate-to-severe atopic eczema (AE) is limited. Such data must come from well-designed prospective patient registries. Standardisation of data collection is needed for direct comparisons and data pooling. Read More

Br J Dermatol 2019 Feb 4. Epub 2019 Feb 4.

St. John's Institute of Dermatology, Guy's and St, Thomas NHS Foundation Trust, London, UK.

Molluscum contagiosum virus (MCV) infection in the setting of atopic dermatitis (AD), also known as eczema molluscatum, can represent a significant treatment challenge to the dermatologist. We report four patients with severe AD and disseminated MCV infection who experienced clearance of their MCV infection following treatment with dupilumab, a fully human monoclonal antibody against interleukin(IL)-4 receptor alpha licenced for the treatment of moderate to severe AD. This article is protected by copyright. Read More

Br J Dermatol 2019 Feb 4. Epub 2019 Feb 4.

Regeneron Pharmaceuticals, Inc, Tarrytown, NY, USA.

Moderate-to-severe atopic dermatitis (AD) can affect different parts of the body, and some adults have more localized AD, such as face and neck involvement. Compared with non-exposed areas, such as the trunk, exposed areas such as the face, neck, and hands could be more vulnerable to environmental allergens and irritants and can be more refractory to topical therapies. Local adverse effects of topical therapies are more likely to occur on the face and neck. Read More

Front Cell Infect Microbiol 2018 21;8:451. Epub 2019 Jan 21.

Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.

As therapies for atopic dermatitis (AD) based on live biotherapeutic products (LBP) are developed, the potential displacement of biotherapeutic strains, and species to mucosal sites where they are not naturally found is of investigative interest. However, formal assessment of the toxicity potential of healthy skin commensal organisms has not been reported in the literature. Our previous research indicates that topical application of live to treat AD was associated with clinical benefit on the skin, but the effects of exposure via inhalation, eye inoculation, and ingestion were unknown. Read More