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    24182 results match your criteria Atopic Dermatitis

    1 OF 484

    Neutralization of IL-17C reduces skin inflammation in mouse models of psoriasis and atopic dermatitis.
    J Invest Dermatol 2018 Feb 20. Epub 2018 Feb 20.
    MorphoSys AG, Semmelweisstraβe 7, 82152 Planegg, Germany.
    Interleukin-17C (IL-17C) is a functionally distinct member of the IL-17 family that was implicated to play a role in the pathogenesis of psoriasis. Here we confirmed that IL-17C is involved in psoriasis and explored potential roles for IL-17C in atopic dermatitis (AD). An anti-IL-17C antibody, MOR106, was generated that potently and selectively binds to human and mouse IL-17C, thereby inhibiting the binding of IL-17C to its IL-17RE receptor. Read More

    Attenuated activation of homeostatic glucocorticoid in keratinocytes induces alloknesis via aberrant artemin production.
    J Invest Dermatol 2018 Feb 20. Epub 2018 Feb 20.
    Dermatology, Department of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.
    Intense chronic itch significantly reduces quality of life for atopic dermatitis (AD) patients, impairing daily activity. While abnormal itch sensation can be induced by innocuous stimuli, known as alloknesis, the mechanisms driving this process remain obscure. Psychological and environmental stimuli are known to aggravate AD symptoms. Read More

    Dupilumab treatment in moderate-to-severe atopic dermatitis: A systematic review and meta-analysis.
    J Dermatol Sci 2018 Feb 19. Epub 2018 Feb 19.
    Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China. Electronic address:
    Background: Dupilumab, a fully human monoclonal antibody against the interleukin-4-receptor α subunit, has been developed and used in clinical trials to treat atopic dermatitis (AD).

    Objective: We aimed to assess the overall efficacy and safety of dupilumab treatment in AD.

    Methods: PubMed, Embase, Cochrane library databases, and the Chinese Biological Medicine (CBM) published up to September 2017 were searched. Read More

    Dupilumab: A review of its use in the treatment of atopic dermatitis.
    J Am Acad Dermatol 2018 Mar;78(3S1):S28-S36
    Probity Medical Research, Waterloo, Ontario, Canada.
    Atopic dermatitis (AD) is a chronic, pruritic immune-mediated inflammatory dermatosis characterized by a T helper 2 (Th2) immune response phenotype and may be associated with systemic inflammation. Dupilumab is an interleukin 4 (IL-4) receptor α-antagonist that inhibits IL-4 and IL-13 signaling through blockade of the shared IL-4α subunit. Blockade of IL-4/13 is effective in reducing Th2 response. Read More

    Glucocorticosteroids and ciclosporin do not significantly impact canine cutaneous microbiota.
    BMC Vet Res 2018 Feb 23;14(1):51. Epub 2018 Feb 23.
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, NC, 27607, USA.
    Background: As prednisone and ciclosporin can have immunosuppressive effects and have been considered potential predisposing factors for skin infections, we investigated the impact of these drugs on the diversity of the cutaneous microbiota, the abundance of Malassezia and infection with Papillomaviruses.

    Results: Six atopic, asymptomatic Maltese-beagle dogs were treated with ciclosporin for one month and then with prednisone for another month, with a one-month wash-out between treatments. The dogs were sampled on the abdomen and pinna before and after each treatment using a swab. Read More

    [New aspects in systemic treatment of atopic dermatitis].
    Hautarzt 2018 Feb 22. Epub 2018 Feb 22.
    Abteilung für Immundermatologie und experimentelle Allergologie, Klinik für Dermatologie, Allergologie und Venerologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.
    In severe cases of atopic dermatitis (AD) systemic treatment is indicated. So far, cyclosporine and systemic glucocorticosteroids represented the only systemic treatment options approved for the indications of AD in Germany; however, from clinical practice there is increasing evidence for beneficial therapeutic effects in AD by other immunosuppressive or immunomodulatory substances, such as mycophenolate, methotrexate, alitretinoin and ustekinumab. Beyond this, ongoing research activities focus on a better understanding of genetic and immunological aspects of this chronic inflammatory skin disease. Read More

    In-silico studies of isolated phytoalkaloid against Lipoxygenase: study based on possible correlation.
    Comb Chem High Throughput Screen 2018 Feb 20. Epub 2018 Feb 20.
    King Fahd Medical Research Center, King Abdulaziz University, Jeddah 22252. Saudi Arabia.
    Lipoxygenase (LOX) enzymes play an important role in the pathophysiology of several inflammatory and allergic diseases including bronchial asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, rheumatoid arthritis, chronic obstructive pulmonary disease. Inhibitors of the LOX are believed to be an ideal approach in the treatment of diseases caused by its over-expression. In this regard, several synthetic and natural agents are under investigation worldwide. Read More

    Family management of childhood atopic dermatitis.
    J Adv Nurs 2018 Feb 22. Epub 2018 Feb 22.
    College of Nursing, Mo-Im Kim Nursing Institute, Yonsei University, Seoul, Korea.
    Aims: To identify the variables that affect family management of childhood atopic dermatitis and establish a prediction model based on Bandura's self-efficacy theory.

    Background: Atopic dermatitis is a chronic recurrent skin disease and common health problem in childhood. It is necessary to use an approach that includes parental factors when considering the effective management of childhood atopic dermatitis. Read More

    Allergy-preventive effects of linarinic acid and its tetrahydropyrrolo[2,1-b]quinazoline derivatives isolated from Linaria vulgaris.
    J Nat Med 2018 Feb 21. Epub 2018 Feb 21.
    School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, 11-68 Koshien Kuban-cho, Nishinomiya, Hyogo, 663-8179, Japan.
    Linarinic acid, (-)-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazoline-1-carboxylic acid (4a), was isolated from the ethanol extract of Linaria vulgaris Mill. In our previous study, a series of tetrahydropyrrolo[2,1-b]quinazoline derivatives 4b, 4c, 5a, 5b, 6a and 6b that were structurally related to 4a and evaluated as neuroprotective agents were synthesized. The aim of the present study was to investigate the novel features of these compounds. Read More

    Lipid abnormalities in atopic skin are driven by type 2 cytokines.
    JCI Insight 2018 Feb 22;3(4). Epub 2018 Feb 22.
    Department of Pediatrics, and.
    Lipids in the stratum corneum of atopic dermatitis (AD) patients differ substantially in composition from healthy subjects. We hypothesized that hyperactivated type 2 immune response alters AD skin lipid metabolism. We have analyzed stratum corneum lipids from nonlesional and lesional skin of AD subjects and IL-13 skin-specific Tg mice. Read More

    A preliminary study on topical ozonated oil in the therapeutic management of atopic dermatitis in murine.
    J Dermatolog Treat 2018 Feb 22:1-21. Epub 2018 Feb 22.
    c Department of Immunology , College of Basic Medical Sciences, Central South University , Changsha , Hunan , China.
    Atopic dermatitis (AD) is an inflammatory skin disease characterized as a Th2-predominant immune response. Patients are susceptible to infection. Ozone is used for wound treatment due to its anti-infection features. Read More

    Inhibitory Activity of Allergic Contact Dermatitis and Atopic Dermatitis-Like Skin in BALB/c Mouse through Oral Administration of Fermented Barks of Alnus sibirica.
    Molecules 2018 Feb 18;23(2). Epub 2018 Feb 18.
    Laboratory of Pharmacognosy and Natural Product based Medicine, College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea.
    Phytochemical isolation of fermented(FAS) which was produced by usingsubsp., exhibited multiple and different composition compared with the original plant. Anti-allergic contact dermatitis (anti-ACD)/anti-atopic dermatitis (anti-AD) activities (visual observation and regulation of Th₁/Th₂ cytokines and IgE in blood) of FAS and the barks ofextract (AS) and the two diarylheptanoids, hirsutenone () and muricarpon B (), which are major components of FAS, were measured in vitro and in vivo. Read More

    Potentiation of skin TSLP production by a cosmetic colorant leads to aggravation of dermatitis symptoms.
    Chem Biol Interact 2018 Feb 17;284:41-47. Epub 2018 Feb 17.
    BK21Plus Team, College of Pharmacy, The Catholic University of Korea, Bucheon, 14662, Republic of Korea. Electronic address:
    Certain cosmetic colorants are irritant to skin or aggravate dermatitis. Thymic stromal lymphopoietin (TSLP) plays an important role in the initiation and progress of skin inflammation and atopic dermatitis by triggering Th2 immune responses. However, the effects of cosmetic colorants on TSLP production are unknown yet. Read More

    Trends in Atopic Dermatitis Management: Comparison of 1990-1997 to 2003-2012.
    J Drugs Dermatol 2018 Feb;17(2):135-140
    Background: Atopic dermatitis (AD) is primarily treated with topical therapies, systemic immunosuppressants, or adjunctive therapies.

    Objective: As novel treatment approaches for AD emerge, we characterize AD treatment and examine trends in treatment over time.

    Methods: Visits for AD were identified in the 2003-2012 National Ambulatory Medical Care Survey (NAMCS). Read More

    Are skin equipment for assessing childhood eczema any good?
    J Dermatolog Treat 2018 Feb 20:1-15. Epub 2018 Feb 20.
    a The Chinese University of Hong Kong, Prince of Wales Hospital , Hong Kong.
    Aim: Symptomatology and severity of atopic dermatitis (AD) can be objectively measured with equipment. This study aimed to compare skin measurements and investigate their correlations with various clinical severity scores.

    Methods: Skin hydration (SH), transepidermal water loss (TEWL), pH, erythema, pigmentation and ITA (individual typology angle) were measured (using Delfin, Courage+Khazaka and Mettler Toledo equipment), and correlated with Patient-Oriented Eczema Measure (POEM, a short-term subjective-symptom score), Scoring Atopic Dermatitis (SCORAD, a short-term subjective-symptom and objective-sign score), Nottingham Eczema Severity Score (NESS, a long-term subjective-symptom score), Children Dermatology Life Quality Index (CDLQI, a short-term subjective-symptom score) with Spearman's rho coefficient. Read More

    Major role for TRPV1 and InsP3R in PAR-2-elicited inflammatory mediator production in differentiated human keratinocytes.
    J Invest Dermatol 2018 Feb 16. Epub 2018 Feb 16.
    University of Western Brittany, Laboratory Interaction Neurons-Keratinocytes (LINK), EA4685, Brest, France. Electronic address:
    Proteinase-activated receptor-2 (PAR-2) activation in basal keratinocytes stimulates inflammation via the Ca-dependent production of mediators such as interleukin (IL)-1β, tumor necrosis factor (TNF)-α and thymic stromal lymphopoietin (TSLP). In this study, we investigated PAR-2 calcium signaling and the consequent production of inflammatory mediators in differentiated human primary keratinocytes (DhPKs). Stimulation with the PAR-2 activating peptide SLIGKV promoted Castore depletion in both undifferentiated human primary keratinocytes (UhPKs) and DhPKs. Read More

    Atopy Associated With Positive Patch Test and Possible Allergic Contact Dermatitis.
    J Cutan Med Surg 2018 Feb 1:1203475418758988. Epub 2018 Feb 1.
    2 Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC, Canada.
    Background: Atopy is a genetic predisposition to the development of allergic reactions and the increased production of immunoglobulin E (IgE) upon exposure to environmental antigens. Clinical manifestations of atopy include asthma, atopic dermatitis (AD), and allergic rhinoconjunctivitis (ARC).

    Objective: To determine if cutaneous delayed hypersensitivity reactions (CDHRs) as assessed by patch testing are higher among patients with a history of atopy and with a familial predisposition to atopy. Read More

    Atopic Dermatitis in Diverse Racial and Ethnic Groups - Variations in Epidemiology, Genetics, Clinical Presentation, and Treatment.
    Exp Dermatol 2018 Feb 19. Epub 2018 Feb 19.
    Department of Dermatology, Mount Sinai St. Luke's and Mount Sinai West, 1090 Amsterdam Avenue, Suite 11B, New York, NY, 10025.
    Atopic dermatitis (AD) is a chronic inflammatory skin condition that affects diverse ethnic groups with varying prevalence. Despite a predominance of studies in individuals of European ancestry, AD has been found to occur more frequently in Asian and black individuals than whites. Therefore, an understanding of the unique clinical features of AD in diverse ethnic groups, as well as the differences in genetic polymorphisms that influence susceptibility to AD and response to current therapies, is paramount for management of an increasingly diverse patient population. Read More

    Influence of topical steroids on intraocular pressure in patients with atopic dermatitis.
    Allergol Int 2018 Feb 15. Epub 2018 Feb 15.
    Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
    Background: Topical corticosteroids (TCS) can induce adverse effects, such as skin atrophy. Although TCS can cause increases in intraocular pressure (IOP), the effects of daily TCS use on IOP have not been fully elucidated. We evaluated the clinical doses of TCS and the change in the IOP during the daily treatment of atopic dermatitis (AD). Read More

    Exposure to dogs but not cats is associated to a decrease in the prevalence in atopic dermatitis amongst school-children.
    Allergol Immunopathol (Madr) 2018 Feb 15. Epub 2018 Feb 15.
    Psicología Clínica, Eulogio Parra No. 2330-301, Col. Las Américas, C.P. 44650, Guadalajara, Jalisco, Mexico.
    Introduction: The association regarding the exposure to pets, especially cats and dogs, and the prevalence of allergic diseases is inconsistent.

    Objective: We analyzed the role played by early exposure to dogs or cats in the prevalence of allergic diseases amongst school-aged children.

    Method: Through a cross-sectional study, we examined 756 children, aged 6-7; these candidates were selected through cluster sampling. Read More

    Pathophysiology and Management of Mild to Moderate Pediatric Atopic Dermatitis.
    J Pediatr Health Care 2018 Mar - Apr;32(2):S2-S12
    Atopic dermatitis (AD), or eczema, is a chronic inflammatory skin condition characterized by relapsing pruritic and dry, scaly lesions. AD affects 10% to 20% of children in the United States and significantly affects the quality of life of patients and their families. Primary care providers (PCPs) are often the first point of contact for the management of AD symptoms. Read More

    Bamboo salt suppresses skin inflammation in mice with 2, 4-dinitrofluorobenzene-induced atopic dermatitis.
    Chin J Nat Med 2018 Feb;16(2):97-104
    Department of Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea. Electronic address:
    Bamboo salt (BS) is a traditional Korean food, and has been reported to have anti-cancer, anti-inflammatory, and anti-metastatic effects. However, the anti-atopic dermatitis (AD) activity of BS has not been described yet. In the present study, we examined the preventive effect of BS on AD. Read More

    The role of the OVOL1-OVOL2 axis in normal and diseased human skin.
    J Dermatol Sci 2018 Feb 12. Epub 2018 Feb 12.
    Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan; Research and Clinical Center for Yusho and Dioxin, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan; Division of Skin Surface Sensing, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan.
    OVOLs (OVO-like proteins) are ubiquitously conserved genes encoding a CHzinc finger transcription factor in mammals. Functional studies on OVOL1 and OVOL2 using knockout mice have suggested that these genes play a pivotal role in the development of epithelial tissues arising from germ cells; however, the role of the OVOL1-OVOL2 axis in normal and diseased tissues remains unclear. This review highlights recent advances in understanding how the OVOL1-OVOL2 axis modulates cell differentiation and proliferation in human keratinocytes, hair follicles, and benign or malignant skin tumors including squamous cell carcinoma and malignant melanoma. Read More

    JAK/STAT inhibitors and other small molecule cytokine antagonists for the treatment of allergic disease.
    Ann Allergy Asthma Immunol 2018 Feb 14. Epub 2018 Feb 14.
    Incyte Corporation, Wilmington, Delaware.
    Objective: To provide an overview of janus kinase (JAK), chemoattractant receptor-homologous molecule expressed on T-helper 2 cells (CRTH2), and phosphodiesterase 4 (PDE4) inhibitors in allergic disorders.

    Data Sources: PubMed literature review.

    Study Selections: Articles included in this review discuss the emerging mechanism of action of small molecule inhibitors and their utilization in atopic dermatitis (AD), asthma, and allergic rhinitis (AR). Read More

    [Microbiome, atopic eczema and blockade of type 2 immunity].
    Hautarzt 2018 Feb 16. Epub 2018 Feb 16.
    Klinik und Poliklinik für Dermatologie und Allergologie, Technische Universität München, Biedersteinerstr. 29, 80802, München, Deutschland.
    Atopic dermatitis affects roughly 20% of children and 3% of adults in Germany and other industrial countries, with an increasing prevalence. Its causality has still not been conclusively clarified but a type‑2 T‑helper cell mediated immunity reaction (type 2 immunity) dominates cutaneous inflammation. In the quest for the underlying pathogenic mechanisms and the development of improved prevention and treatment options, attention is also increasingly being paid to the influence of microbial colonization. Read More

    [Regained freedom for patients with atopic dermatitis; fast and long-term effects of dupilumab].
    Ned Tijdschr Geneeskd 2018 ;162(0):D2539
    Erasmus MC, afd. Dermatologie, Rotterdam.
    Dupilumab is the first and long-awaited biological for treatment of moderate to severe atopic dermatitis. In randomised clinical trials approximately 40% of patients using dupilumab 300 mg every two weeks were clear or almost clear of their eczema after 16 and 52 weeks. We now face the challenge of patient stratification to limit the budget impact of dupilumab and hope that more targeted therapies for atopic dermatitis will follow soon. Read More

    GP and parent dissonance about the assessment and treatment of childhood eczema in primary care: a qualitative study.
    BMJ Open 2018 02 15;8(2):e019633. Epub 2018 Feb 15.
    Centre for Academic Primary Care, Bristol Medical School, University of Bristol, Bristol, UK.
    Objectives: To compare parents' and clinicians' perspectives on the assessment and treatment of children with eczema in primary care.

    Design: Qualitative interview study with purposive and snowball sampling and thematic analysis.

    Setting: 14 general practices in the UK. Read More

    [Patient education for adults with atopic dermatitis according to the ARNE concept].
    Hautarzt 2018 Feb 14. Epub 2018 Feb 14.
    Institut für Medizinische Psychologie, Justus-Liebig-Universität Gießen, Klinikstr. 29, 35392, Gießen, Deutschland.
    Atopic dermatitis (AD) represents a chronic inflammatory skin disease showing a 1-year prevalence of 2-3% during adulthood. In a national randomized, controlled multicenter study initiated by the "Arbeitsgemeinschaft Neurodermitisschulung im Erwachsenenalter" (ARNE, Working Group on Educational Training for Adults with Atopic Dermatitis) a program for structured patient education conducted by a multiprofessional team was developed and evaluated. At 1‑year follow-up, coping behavior with respect to itch (assessed by the "Juckreiz-Kognitions-Fragebogen", p < 0. Read More

    Is atopic dermatitis associated with obesity? A systematic review of observational studies.
    J Eur Acad Dermatol Venereol 2018 Feb 14. Epub 2018 Feb 14.
    Department of Dermatology, Bispebjerg Hospital.
    Obesity has been associated with atopic dermatitis (AD), however the results have been conflicting. Our aim was to provide an update on current knowledge from observational studies addressing the possible association between obesity and AD. Systematic literature review was performed by identifying studies addressing a possible link between AD and overweight/obesity from PubMed, Embase, and the Cochrane Library in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA)-guidelines. Read More

    Drug survival and post-drug survival of first-line immunosuppressive treatments for atopic dermatitis: comparison between methotrexate and cyclosporine.
    J Eur Acad Dermatol Venereol 2018 Feb 14. Epub 2018 Feb 14.
    University Rennes 1, Rennes, France.
    Introduction: Cyclosporine and methotrexate are the two preferred first-line immunosuppressive treatments in atopic dermatitis. The aim of this study was to compare the treatment profiles of methotrexate and cyclosporine in daily practice as the first-line immunosuppressive treatment in atopic dermatitis, using two survival analyses, "drug survival" (time on the drug) and "post-drug survival" (time between two drugs).

    Methods: Retrospective study including patients with moderate-to-severe atopic dermatitis treated with methotrexate or cyclosporine as the first-line immunosuppressive treatment. Read More

    Changes in the Anti-Allergic Activities of Sesame by Bioconversion.
    Nutrients 2018 Feb 14;10(2). Epub 2018 Feb 14.
    Department of Food Science and Biotechnology, Kangwon National University, Chuncheon 24341, Korea.
    Sesame is an important oilseed crop, which has been used as a traditional health food to ameliorate the prevention of various diseases. We evaluated the changes in the anti-allergic activities of sesame by bioconversion. SDS-PAGE of non-fermented sesame proteins showed major allergen bands, while that of fermented sesame showed only a few protein bands. Read More

    Retarder action of isosorbide in a microemulsion for a targeted delivery of ceramide NP into the.
    Pharmazie 2017 Aug;72(8):440-446
    Ceramide [NP] is an integral component of the stratum corneum (SC) lipid matrix and is capable of forming tough and stable lamellar structures. It was proven, that in skin diseases as psoriasis or atopic dermatitis different ceramide (CER) classes, including [NP], are degraded. It is obvious that topically application of CER on impaired skin is useful for repairing the skin barrier but a tendency for low penetration due to its poor solubility in conventional dosage forms was observed. Read More

    International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis.
    Int Forum Allergy Rhinol 2018 Feb;8(2):108-352
    Otolaryngology, University of Michigan, USA.
    Background: Critical examination of the quality and validity of available allergic rhinitis (AR) literature is necessary to improve understanding and to appropriately translate this knowledge to clinical care of the AR patient. To evaluate the existing AR literature, international multidisciplinary experts with an interest in AR have produced the International Consensus statement on Allergy and Rhinology: Allergic Rhinitis (ICAR:AR).

    Methods: Using previously described methodology, specific topics were developed relating to AR. Read More

    MicroRNA-31 and MicroRNA-155 Are Overexpressed in Ulcerative Colitis and Regulate IL-13 Signaling by Targeting Interleukin 13 Receptor α-1.
    Genes (Basel) 2018 Feb 13;9(2). Epub 2018 Feb 13.
    Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton School of Medicine, Southampton SO17 1BJ, UK.
    Interleukin-13 (IL-13) is an important Type 2 T helper (Th2) cytokine, controlling biological functions in epithelium and has been linked to asthma, atopic dermatitis and ulcerative colitis (UC). Interleukin-13 signals through IL-13 receptor α-1 ((gene) and IL13Rα1 (protein)), a receptor that can be regulated by microRNAs (miRs). MicroRNAs are small non-coding single-stranded RNAs with a role in several pathologies. Read More

    [Atopic dermatitis physiopathology].
    Ann Dermatol Venereol 2017 Dec;144 Suppl 5:VS8-VS14
    Département de dermatologie et allergologie, bâtiment Canton, hôpital Brabois, 54500 Vandœuvre lès-Nancy, France. Electronic address:
    Our understanding of the physiopathology of atopic dermatitis has much improved over the recent years. Epidermal barrier alterations are integrated into 2 theories called inside out and outside in. They are related to complex immune abnormalities. Read More

    [Epidemiology of atopic dermatitis].
    Ann Dermatol Venereol 2017 Dec;144 Suppl 5:VS4-VS7
    Department of Dermatology, Henri-Mondor Hospital ; Faculty of Medicine, Saint Joseph University, Beirut, Lebanon.
    Atopic dermatitis (AD) is a chronic pruriginous skin disease which usually begins during early life (before the age of 2 years). Recently, the persistence of the disease in adulthood has been clearly established at least in a subset of patients, with frequent moderate to severe forms. The exact prevalence of the disease varies according to the study design and its estimate remains difficult mainly because of the lack of consensual diagnostic tools easily usable in population studies. Read More

    [Current and upcoming treatments of adult atopic dermatitis].
    Ann Dermatol Venereol 2017 Dec;144 Suppl 5:VS29-VS37
    Service de dermatologie, hôpital Archet 2, CHU de Nice, CS 23079, 06202, Nice Cedex 3, France. Electronic address:
    The treatment of atopic dermatitis in adults is based on the use of topical steroids and emollients. When AD is resistant to a well-conducted topical treatment, phototherapy or systemic treatments can be used: ciclosporin, methotrexate, azathioprine or mycophenolate mofetil. The therapeutic landscape of adult AD is about to change and even be revolutionized by the imminent arrival of new treatments: topical phosphodiesterase 4 inhibitors, topical or systemic JAK inhibitors, anti-IL-4 and/or antiIL-13 biotherapies (dupilumab, tralokinumab, lebrikizumab), anti-IL-31 (nemolizumab), anti-TSLP. Read More

    [Burden of atopic dermatitis in adults].
    Ann Dermatol Venereol 2017 Dec;144 Suppl 5:VS23-VS28
    Service de dermatologie, centre hospitalier universitaire de Brest, 2 avenue Foch, 29200 Brest; laboratoire interactions épithéliums neurones (LIEN-EA4685), université de Bretagne occidentale, Brest, France. Electronic address:
    Atopic dermatitis may have a very important impact on adults. Visible lesions, but especially near-permanent pruritus or sometimes pain for decades, necessarily have consequences on all aspects of everyday life, including sleep, and professional, social, family and emotional life. Financial consequences are also possible. Read More

    [Atopic dermatitis of the adult: clinical presentation, complications and comorbidities].
    Ann Dermatol Venereol 2017 Dec;144 Suppl 5:VS15-VS22
    Service de dermatologie, polyclinique Courlancy, groupe Courlancy, 38 bis, rue de Courlancy, Reims, France. Electronic address:
    Atopic dermatitis (DA) is a chronic inflammatory skin disease. Its incidence and prevalence is increasing, especially in industrialized countries. The prevalence of AD in adults is estimated at 1-3 % of the general population and can present as adult-onset AD, or as infantile/childhood AD that persists, or recurs in adulthood. Read More

    Mast cell-neural interactions contribute to pain and itch.
    Immunol Rev 2018 Mar;282(1):168-187
    Department of Dermatology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
    Mast cells are best recognized for their role in allergy and anaphylaxis, but increasing evidence supports their role in neurogenic inflammation leading to pain and itch. Mast cells act as a "power house" by releasing algogenic and pruritogenic mediators, which initiate a reciprocal communication with specific nociceptors on sensory nerve fibers. Consequently, nerve fibers release inflammatory and vasoactive neuropeptides, which in turn activate mast cells in a feedback mechanism, thus promoting a vicious cycle of mast cell and nociceptor activation leading to neurogenic inflammation and pain/pruritus. Read More

    Role of mast cells and basophils in pruritus.
    Immunol Rev 2018 Mar;282(1):248-264
    Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA, USA.
    To protect our body systems, there is a constant interactive conversation between the skin nervous and immune system. Important elements of this conversation in the skin include mast cells, basophils, and sensory nerve fibers. These cells employ a vast array of sensors that detect danger and react accordingly. Read More

    Enolase-1 expression in the stratum corneum is elevated with parakeratosis of atopic dermatitis and disrupts the cellular tight junction barrier in keratinocytes.
    Int J Cosmet Sci 2018 Feb 11. Epub 2018 Feb 11.
    Department of Dermatology, Toho University Ohashi Medical Center.
    Objective: Previous studies have shown that enolase-1 (ENO1) in the stratum corneum (SC) is more highly expressed in patients with atopic dermatitis (AD) than in healthy individuals, suggesting that it is a novel biomarker for evaluating skin condition in patients with AD. However, the mechanism underlying high ENO1 expression in the SC and its pathological relevance in AD are unclear. In this study, the relationship between ENO1 expression and keratinization of epidermis was investigated and the role of high ENO1 expression in keratinocytes was characterized. Read More

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