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    An evaluation of vitamin D levels in children with seasonal allergic rhinitis during pollen season.
    Pediatr Allergy Immunol 2017 Apr 27. Epub 2017 Apr 27.
    Department of Pediatrics, Division of Pediatric Immunology and Allergy, Ondokuz Mayıs Univesity, Samsun, Turkey.
    Background: Serum vitamin D levels have not been studied in children with seasonal allergic rhinitis (SAR). The aim of this study was to evaluate the vitamin D levels of children with SAR and to compare them to levels in healthy children during pollen season.

    Methods: This study was conducted in 100 children with SAR and 100 healthy controls. Read More

    Prevalence of and work-related risk factors for hand eczema in a Norwegian general population (The HUNT Study).
    Contact Dermatitis 2017 Apr 27. Epub 2017 Apr 27.
    Department of Occupational Medicine, Haukeland University Hospital, 5021, Bergen, Norway.
    Background: Chemical exposures at work and at home may cause hand eczema. However, this has been scarcely described for Norway.

    Objectives: To investigate the prevalence of, and occupational risk factors for, hand eczema in Norway. Read More

    1,6-O,O-Diacetylbritannilactone suppresses activation of mast cell and airway hyper-responsiveness.
    Immunopharmacol Immunotoxicol 2017 Apr 27:1-7. Epub 2017 Apr 27.
    a Tianjin Key Laboratory on Technologies Enabling, Development of Clinical Therapeutics and Diagnostics, School of Pharmacy , Tianjin Medical University , Tianjin , People's Republic of China.
    Mast cells play critical roles in allergic disorders such as atopic dermatitis and allergic asthma. The aim of this study was to investigate the anti-inflammatory and anti-asthmatic activities of 1,6-O,O-diacetylbritannilactone (OODBL) isolated from Inula japonica Thunb. (I. Read More

    Discordance Between Physician- and Patient-Reported Disease Severity in Adults with Atopic Dermatitis: A US Cross-Sectional Survey.
    Am J Clin Dermatol 2017 Apr 26. Epub 2017 Apr 26.
    Sanofi, Bridgewater, NJ, USA.
    Background: There is limited understanding of severity rating of atopic dermatitis in clinical practice.

    Objectives: To evaluate the agreement between physician- and patient-rated severity of atopic dermatitis.

    Methods: Data were collected from the 2014 Adelphi US Atopic Dermatitis Disease Specific Programme, a cross-sectional survey of physicians and their patients with a history of moderate-to-severe atopic dermatitis; patients voluntarily completed a questionnaire. Read More

    [Neurodermatitis : Atopy of the skin].
    Ophthalmologe 2017 Apr 26. Epub 2017 Apr 26.
    Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Rosalind-Franklin-Str. 7, 24105, Kiel, Deutschland.
    Atopic dermatitis is one of the most common skin diseases and is associated with an impaired quality of life due to tormenting itching and stigmatization. The disease almost always manifests in early childhood and exhibits specific features in this phase, with involvement of the extensor sides of the extremities. During the further course of disease, the typical flexor involvement becomes quite clear and a considerable proportion of patients develop the associated atopic respiratory diseases. Read More

    Protective Effect of Botulinum Toxin Type A Against Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice.
    Dermatol Surg 2017 Apr 24. Epub 2017 Apr 24.
    *Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea; †Laboratory of Cutaneous Aging Research, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea; ‡Institute of Dermatological Science, Seoul National University, Seoul, Korea; §Department of Dermatology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
    Background: Botulinum neurotoxin (BTX) A possesses various biological activities, including anti-inflammatory and antipruritic actions. Human and animal studies have shown that BTX is effective in treating histamine-induced itch, lichen simplex chronicus, psoriasis, rosacea, allergic rhinitis, and scar prevention. However, its effect on atopic dermatitis (AD) has not been studied yet. Read More

    Rapid Detection of Staphylococcus aureus and Methicillin-Resistant S. aureus in Atopic Dermatitis by Using the BD Max StaphSR Assay.
    Ann Lab Med 2017 Jul;37(4):320-322
    Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.
    Eczematous lesions of atopic dermatitis (AD) patients are known to be a source of Staphylococcus aureus (SA) transmission and might be a reservoir for community-associated methicillin-resistant SA (MRSA). The BD Max StaphSR (BD-SR) is a fully automated, multiplex real-time PCR assay for the direct detection and differentiation of SA and MRSA from nasal swab samples. We evaluated the detection rates of SA and MRSA from skin lesions of outpatients with AD using the BD-SR assay, and determined the usefulness of the BD-SR assay. Read More

    Lack of Association between Toll-like Receptor 2 Polymorphisms (R753Q and A-16934T) and Atopic Dermatitis in Children from Thrace Region of Turkey.
    Balkan Med J 2017 Apr 6. Epub 2017 Apr 6.
    Background: Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. A complex interaction of both genetic and environmental factors is thought to contribute to the disease. Recently relations between single nucleotide polymorphisms (SNPs) of toll-like receptors (TLRs) and AD have been reported. Read More

    Absorption, distribution, metabolism and excretion of the oral prostaglandin D2 receptor 2 (DP2) antagonist fevipiprant (QAW039) in healthy volunteers and in vitro.
    Drug Metab Dispos 2017 Apr 25. Epub 2017 Apr 25.
    Novartis Pharma AG.
    Fevipiprant is a novel oral prostaglandin D2 receptor 2 (DP2; also known as CRTh2) antagonist, which is currently in development for the treatment of severe asthma and atopic dermatitis. We investigated the absorption, distribution, metabolism, and excretion properties of fevipiprant in healthy subjects after a single 200 mg oral dose of [(14)C]-radiolabeled fevipiprant. Fevipiprant and metabolites were analyzed by liquid chromatography coupled to tandem mass spectrometry and radioactivity measurements, and mechanistic in vitro studies were performed to investigate clearance pathways and covalent plasma protein binding. Read More

    [Diagnostic approach of erythroderma in the adult].
    Rev Med Inst Mex Seguro Soc 2017 May-Jun;55(3):353-360
    Centro Dermatológico "Dr. Ladislao de la Pascua", Secretaría de Salud de la Ciudad de México, Ciudad de México, México.
    Erythroderma consists on erythema and scaling that covers more than 90% of the cutaneous surface. It has multiple causes and for the most common we can use the acronym PALM (psoriasis, atopic dermatitis, lymphoproliferative disease and medication). It is important to diagnose the cause in order to get a prognosis and a targeted treatment. Read More

    Topical corticosteroid phobia in atopic dermatitis: international feasibility study of the TOPICOP score.
    Allergy 2017 Apr 25. Epub 2017 Apr 25.
    Department of Dermatology, Bordeaux CHU, Bordeaux, France.
    Background: Adherence to topical corticosteroids (TCS) is essential for the effective treatment of atopic dermatitis but can be limited by concerns about their use. This study examined the feasibility of applying the validated TOPICOP score for assessing TCS phobia across different countries.

    Methods: This was a prospective multicenter feasibility study conducted in 21 hospitals in 17 countries. Read More

    Randomized, double-blind, placebo-controlled, parallel-group study of the effect of Lactobacillus paracasei K71 intake on salivary release of secretory immunoglobulin A.
    Biosci Microbiota Food Health 2017 28;36(2):55-63. Epub 2016 Dec 28.
    Kameda Seika Co., Ltd., 3-1-1 Kameda-Kogyodanchi, Konan-ku, Niigata-shi, Niigata 950-0198, Japan.
    Lactobacillus paracasei K71 was shown to be effective in alleviating the severity of atopic dermatitis in a randomized controlled trial, and a preliminary open-label trial suggested that strain K71 intake enhanced secretory immunoglobulin A (sIgA) release in the saliva. This study investigated the effect of K71 on sIgA release in a randomized, double-blind, placebo-controlled, parallel-group trial. The trial included 62 Japanese subjects aged 20-64 years with relatively low rates of salivary sIgA release. Read More

    Supplemental feeding of a gut microbial metabolite of linoleic acid, 10-hydroxy-cis-12-octadecenoic acid, alleviates spontaneous atopic dermatitis and modulates intestinal microbiota in NC/nga mice.
    Int J Food Sci Nutr 2017 Apr 24:1-11. Epub 2017 Apr 24.
    a Graduate School of Biosphere Science , Hiroshima University , Higashi-Hiroshima , Japan.
    The present study investigated the antiallergic and anti-inflammatory effects of 10-hydroxy-cis-12-octadecenoic acid (HYA), a novel gut microbial metabolite of linoleic acid, in NC/Nga mice, a model of atopic dermatitis (AD). Feeding HYA decreased the plasma immunoglobulin E level and skin infiltration of mast cells with a concomitant decrease in dermatitis score. HYA feeding decreased TNF-α and increased claudin-1, a tight junction protein, levels in the mouse skin. Read More

    Involvement of Fas/FasL pathway in the murine model of atopic dermatitis.
    Inflamm Res 2017 Apr 22. Epub 2017 Apr 22.
    Department of Regenerative Medicine, Military Institute of Hygiene and Epidemiology, Kozielska 4, 01-163, Warsaw, Poland.
    Objective And Design: The aim of this study was to elucidate the role of apoptosis mediated through Fas/FasL pathway using the mouse model of atopic dermatitis (AD).

    Materials And Treatment: AD was induced by epicutaneous application of ovalbumin (OVA) in wild-type C57BL/6, B6. MRL-Faslpr/J (Fas-) and B6Smn. Read More

    Emollients and moisturisers for eczema: abridged Cochrane systematic review including GRADE assessments.
    Br J Dermatol 2017 Apr 22. Epub 2017 Apr 22.
    Dutch Association for People with Atopic Dermatitis (VMCE: Vereniging voor Mensen met Constitutioneel Eczeem), Nijkerk, The Netherlands.
    Eczema is a chronic inflammatory skin disorder with considerable impact on quality of life. Emollients or moisturisers are widely recommended, but are these effective and safe? We searched for randomised controlled trials (RCTs) in the Cochrane Skin Group Specialised Register, CENTRAL in The Cochrane Library, Medline, Embase, LILACS, GREAT database and five trial registers to December 2015. We included 77 RCTs with 6603 participants. Read More

    An Italian multicentre study on adult atopic dermatitis: persistent versus adult-onset disease.
    Arch Dermatol Res 2017 Apr 21. Epub 2017 Apr 21.
    Department of Dermatology, University of Naples Federico II, Naples, Italy.
    Atopic dermatitis (AD) is a chronic, recurrent, inflammatory skin disease which predominantly affects children. However, AD may persist until adulthood (persistent AD), or directly start in adults (adult-onset AD). AD often shows a non-flexural rash distribution, and atypical morphologic variants in adults and specific diagnostic criteria are lacking. Read More

    High probability of comorbidities in bronchial asthma in Germany.
    NPJ Prim Care Respir Med 2017 Apr 21;27(1):28. Epub 2017 Apr 21.
    Department of Experimental Pneumology and Allergology, Saarland University Faculty of Medicine, Homburg/Saar, Germany.
    Clinical experience has shown that allergic and non-allergic respiratory, metabolic, mental, and cardiovascular disorders sometimes coexist with bronchial asthma. However, no study has been carried out that calculates the chance of manifestation of these disorders with bronchial asthma in Saarland and Rhineland-Palatinate, Germany. Using ICD10 diagnoses from health care institutions, the present study systematically analyzed the co-prevalence and odds ratios of comorbidities in the asthma population in Germany. Read More

    Expansion of circulating follicular T helper cells associates with disease severity in childhood atopic dermatitis.
    Immunol Lett 2017 Apr 18. Epub 2017 Apr 18.
    Division of Clinical Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. Electronic address:
    Follicular helper T (TFH) cells play crucial role in B-cell differentiation and antibody production. Although, atopic dermatitis (AD) is often associated with increased serum IgE levels, B-cell mediated responses have not been studied thoroughly. The aim of our study was to investigate the proportion of TFH-like cells in the disease. Read More

    Serum peptides as putative modulators of inflammation in psoriasis.
    J Dermatol Sci 2017 Mar 27. Epub 2017 Mar 27.
    Disease Biomarker Analysis and Molecular Regulation, St. Marianna University Graduate School of Medicine, Japan. Electronic address:
    Background: Psoriasis is a refractory inflammatory disease, however, its pathophysiology is still not fully understood.

    Objective: We tried to identify novel serum peptides associated with the pathophysiology of psoriasis.

    Methods: Serum peptides from 24 patients with psoriasis vulgaris (PV), 10 patients with psoriatic arthritis (PsA), 14 patients with atopic dermatitis (AD), and 23 healthy control (HC) subjects were analyzed by mass spectrometry. Read More

    Phospholipase Cδ1 regulates p38 MAPK activity and skin barrier integrity.
    Cell Death Differ 2017 Apr 21. Epub 2017 Apr 21.
    Laboratory of Genome and Biosignals, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.
    Keratinocytes undergo a unique type of programmed cell death known as cornification, which leads to the formation of the stratum corneum (SC), the main physical barrier of the epidermis. A defective epidermal barrier is a hallmark of the two most common inflammatory skin disorders, psoriasis, and atopic dermatitis. However, the detailed molecular mechanisms of skin barrier formation are not yet fully understood. Read More

    Advances in pharmacotherapeutic management of common skin diseases in neonates and infants.
    Expert Opin Pharmacother 2017 May 21;18(7):717-725. Epub 2017 Apr 21.
    a Dermatology, Department of Experimental, Diagnostic and Specialty Medicine , Sant'Orsola-Malpighi Hospital, University of Bologna , Bologna , Italy.
    Introduction: neonatal and infantile skin diseases are frequently encountered in the clinical practice and represent worldwide a socioeconomic issue. They encompass a wide range of acquired or congenital conditions, including infections, vascular lesions and inflammatory diseases and can present with different degrees of severity, leading in some cases to dramatic complications. Areas covered: In this paper we report the most recent evidences on the management of some common skin diseases in neonates and infants. Read More

    Regulation of Th2 responses by different cell types expressing the interleukin-31 receptor.
    Allergy Asthma Clin Immunol 2017 17;13:23. Epub 2017 Apr 17.
    Animal Resource Development Unit and Genetic Engineering Team, RIKEN Center for Life Science Technologies, 2-2-3 Minatojima-minamimachi, Chuou-ku, Kobe, Hyogo 650-0047 Japan.
    Background: Interleukin-31 (IL-31) is a recently identified cytokine produced by Th2 cells that is involved in the development of atopic dermatitis-induced skin inflammation and pruritus. Its receptor, IL-31RA, is expressed by a number of cell types, including epithelial cells, eosinophils, and activated monocytes and macrophages. To date, however, the regulation of Th2 responses by distinct cell types and tissues expressing IL-31RA has not been well studied. Read More

    Development and validation of an algorithm to accurately identify atopic eczema patients in primary care electronic health records from the UK.
    J Invest Dermatol 2017 Apr 18. Epub 2017 Apr 18.
    Faculty of Epidemiology & Population Health, London School of Hygiene and Tropical Medicine.
    Electronic health records hold great promise for clinical and epidemiologic research. Undertaking atopic eczema (AE) research using such data is challenging due to its episodic and heterogeneous nature. We sought to develop and validate a diagnostic algorithm that identifies AE cases based on codes used for electronic records used in the UK Health Improvement Network (THIN). Read More

    Measuring the impact of dermatological conditions on family and caregivers: a review of dermatology-specific instruments.
    J Eur Acad Dermatol Venereol 2017 Apr 20. Epub 2017 Apr 20.
    Clinical Epidemiology Unit, Istituto Dermopatico dell'Immacolata (IDI)-IRCCS FLMM, Rome, Italy.
    The patient is the centre of a web of relationships and the impact of his/her disease on family members and caregivers must be taken into account. The aim of this study was to identify the specific instruments that measure the impact of a dermatological disease on the quality of life (QoL) of family members, by performing a systematic search of the literature. Fifteen papers were identified, describing the creation and validation of nine instruments. Read More

    Hand eczema, atopic dermatitis and filaggrin mutations in adult Danes: a registry-based study assessing risk of disability pension.
    Contact Dermatitis 2017 Apr 20. Epub 2017 Apr 20.
    Department of Dermatology and Allergy, The National Allergy Research Centre, Copenhagen University Hospital Herlev-Gentofte, 2900, Hellerup, Denmark.
    Background: Atopic dermatitis and hand eczema often impair the ability of people to work. Only a few studies have investigated whether individuals with loss-of-function filaggrin gene (FLG) mutations, who often have severe and early onset of dermatitis, experience occupational consequences.

    Objective: To investigate the personal consequences of having atopic dermatitis and/or hand eczema and FLG mutations. Read More

    Prediction of atopy via total immunoglobulin E levels andskin prick tests in patients with psoriasis.
    Turk J Med Sci 2017 Apr 18;47(2):577-582. Epub 2017 Apr 18.
    Department of Immunology and Allergology, Ankara Atatürk Chest Diseases and Chest Surgery Training and Research Hospital, Ankara, Turkey.
    Background/aim: Although the etiopathogeneses of psoriasis and atopy appear to be different, psoriasis has been found to be associated with atopy and atopic dermatitis. In this study, we aimed to determine the role of atopy by examining the medical history and clinical and laboratory findings of patients with psoriasis.

    Materials And Methods: Patients with psoriasis, asthma patients, and healthy volunteers were included in the study. Read More

    The efficacy of narrowband UVB treatment in pediatricvitiligo: a retrospective analysis of 26 cases.
    Turk J Med Sci 2017 Apr 18;47(2):381-384. Epub 2017 Apr 18.
    Department of Dermatology and Venereology, Faculty of Medicine, Uludağ University, Bursa, Turkey.
    Background/aim: Narrowband UVB (Nb UVB) treatment is commonly used for the management of psoriasis and atopic dermatitis, and is less often used for vitiligo in children. The aim of this study was to evaluate the efficacy and short-term safety of Nb UVB phototherapy in children diagnosed with vitiligo retrospectively.

    Materials And Methods: A total of 26 patients younger than 18 years with the diagnosis of vitiligo and managed with Nb UVB phototherapy as documented in archive records were evaluated. Read More

    A novel JAK inhibitor JTE-052 reduces skin inflammation and ameliorates chronic dermatitis in rodent models: comparison with conventional therapeutic agents.
    Exp Dermatol 2017 Apr 19. Epub 2017 Apr 19.
    Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., Osaka, Japan.
    Janus kinases (JAKs) are required for several inflammatory cytokine signaling pathways and are implicated in the pathogenesis of chronic dermatitis, including atopic dermatitis and psoriasis. JAK inhibitors are therefore promising therapeutic candidates for chronic dermatitis. In this study, we evaluated the effects of the novel JAK inhibitor JTE-052 on inflammatory responses associated with chronic dermatitis, and compared its profile with those of conventional therapeutic agents in rodent models of chronic dermatitis. Read More

    Facies: the value of an old diagnostic tip in pediatric dermatology.
    G Ital Dermatol Venereol 2017 Apr 19. Epub 2017 Apr 19.
    Unit of Pediatics and Medical Genetics, Oasi Institute (IRCCS), Troina, Enna, Italy.
    The authors examine what's meant as facies in medicine. After an introduction to the word's understanding, they move on listing some dermatological conditions associated to peculiar facies in the child. Starting from atopic dermatitis, the authors develop an algorithm including Genodermatoses, Neurocutaneous Disorders, and Multiple Congenital Anomalies Syndromes. Read More

    An Unanticipated Complication of Atopic Dermatitis.
    Pediatr Emerg Care 2017 Apr 18. Epub 2017 Apr 18.
    From the *Queen's University, School of Medicine, Kingston, Ontario; and †Pediatric Dermatology, University of Alberta, Edmonton, Alberta, Canada. Dr MacGillivray is now at the Department of Medicine, Division of Dermatology, University of Alberta, Canada.
    An infant with a history of atopic dermatitis presented to the emergency department on 5 occasions with flulike symptoms. Eventually, this child presented with signs of infection and increased intracranial pressure: fever, bulging anterior fontanel, and leukocytosis. A computed tomography scan identified a large frontal lobe brain abscess. Read More

    External application of NF-κB inhibitor DHMEQ suppresses development of atopic dermatitis-like lesions induced with DNCB/OX in BALB/c mice.
    Immunopharmacol Immunotoxicol 2017 Jun;39(3):157-164
    a Department of Pharmacology, School of Life Science and Biopharmaceutics , Shenyang Pharmaceutical University , Shenyang , China.
    Context: Dehydroxymethylepoxyquinomicin (DHMEQ) which is originally developed as an analog of antibiotic epoxyquinomicin C is a specific and potent inhibitor of NF-κB and has been shown to possess promising potential as an anti-inflammatory and anti-tumor agent.

    Objective: This study examines DHMEQ's effect on therapeutic potential for atopic dermatitis (AD)-like lesions.

    Materials And Methods: AD lesions were chronically induced by the repetitive and alternative application of 2,4-dinitrochlorobenzene (DNCB) and oxazolone (OX) on ears in BALB/c mice. Read More

    2-Year animal carcinogenicity results for crisaborole, a novel phosphodiesterase 4 inhibitor for atopic dermatitis.
    J Dermatol Sci 2017 Mar 30. Epub 2017 Mar 30.
    Anacor Pharmaceuticals, Inc., 1020 E Meadow Circle, Palo Alto 94303, CA, USA.
    Background: Crisaborole is a novel, topical nonsteroidal, anti-inflammatory, phosphodiesterase 4 (PDE4) inhibitor for the treatment of mild to moderate atopic dermatitis.

    Objective: As part of a nonclinical safety testing program, these 2-year studies tested the carcinogenic potential of crisaborole.

    Methods: Crisaborole ointment, 2%, 5%, or 7%, was applied once daily topically to mice, and crisaborole was administered orally to rats at doses of 30, 100, or 300mg/kg/day for up to 104 weeks. Read More

    Sweat allergy: Extrinsic or intrinsic?
    J Dermatol Sci 2017 Mar 9. Epub 2017 Mar 9.
    Department of Dermatology, Integrated Health Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan.
    Sweat is an exacerbation factor in atopic dermatitis (AD) in all age groups. A body core temperature elevation with sweating triggers cholinergic urticaria (CholU). We recently reported that AD symptoms are improved by tannic acid-containing spray, which suppresses the basophil histamine release induced by semi-purified sweat antigen in vitro, and by showering, which removes antigens in sweat from the skin surface. Read More

    Prevalence and Descriptive Epidemiology of Atopic Dermatitis and Its Impact on Quality of Life in Singapore.
    Br J Dermatol 2017 Apr 17. Epub 2017 Apr 17.
    KK Women's & Children's Hospital, Dermatology Service.
    Atopic dermatitis (AD) is a common, chronic, pruritic skin condition that is known to negatively impact the quality of life (QOL) of patients(1,2) . Due to its increasing prevalence, AD can impose a substantial economic burden on a country's healthcare system.(3) A study in 2002 found a prevalence of 20. Read More

    The soft computing-based approach to investigate allergic diseases: a systematic review.
    Clin Mol Allergy 2017 13;15:10. Epub 2017 Apr 13.
    School and Division of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University Hospital "G. Martino", Messina, Italy.
    Background: Early recognition of inflammatory markers and their relation to asthma, adverse drug reactions, allergic rhinitis, atopic dermatitis and other allergic diseases is an important goal in allergy. The vast majority of studies in the literature are based on classic statistical methods; however, developments in computational techniques such as soft computing-based approaches hold new promise in this field.

    Objective: The aim of this manuscript is to systematically review the main soft computing-based techniques such as artificial neural networks, support vector machines, bayesian networks and fuzzy logic to investigate their performances in the field of allergic diseases. Read More

    Korean Red Ginseng improves atopic dermatitis-like skin lesions by suppressing expression of proinflammatory cytokines and chemokines in vivo and in vitro.
    J Ginseng Res 2017 Apr 19;41(2):134-143. Epub 2016 Feb 19.
    Department of Oriental Pharmacy, College of Pharmacy, Wonkwang-Oriental Medicines Research Institute, Wonkwang University, Iksan, Korea.
    Background: The prevalence of allergic inflammatory diseases such as atopic dermatitis (AD), asthma, and allergic rhinitis worldwide has increased and complete recovery is difficult. Korean Red Ginseng, which is the heat-processed root of Panax ginseng Meyer, is widely and frequently used as a traditional medicine in East Asia. In this study, we investigated whether Korean Red Ginseng water extract (RGE) regulates the expression of proinflammatory cytokines and chemokines via the mitogen-activated protein kinases (MAPKs)/nuclear factor kappa B (NF-κB) pathway in allergic inflammation. Read More

    Moving towards endotypes in atopic dermatitis: identification of patient clusters based on serum biomarker analysis.
    J Allergy Clin Immunol 2017 Apr 12. Epub 2017 Apr 12.
    Department of Dermatology and Allergology, University Medical Center Utrecht, Utrecht, the Netherlands; Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address:
    Background: Atopic dermatitis (AD) is a complex, chronic, inflammatory skin disease with a diverse clinical presentation. It is however unclear whether this diversity exists at a biological level.

    Objective: To test the hypothesis that AD is heterogeneous at the biological level of individual inflammatory mediators. Read More

    The Molecular Revolution in Cutaneous Biology: The Era of Genome-Wide Association Studies and Statistical, Big Data, and Computational Topics.
    J Invest Dermatol 2017 May;137(5):e113-e118
    National Heart and Lung Institute, Imperial College, London, UK. Electronic address:
    The investigation of biological systems involving all organs of the body including the skin is in era of big data. This requires heavy-duty computational tools, and novel statistical methods. Microarrays have allowed the interrogation of thousands of common genetic markers in thousands of individuals from the same population (termed genome wide association studies or GWAS) to reveal common variation associated with disease or phenotype. Read More

    Atopic Dermatitis and Comorbidities: Added Value of Comprehensive Dermatoepidemiology.
    J Invest Dermatol 2017 May;137(5):1009-1011
    Department of Dermatology, Erasmus University Medical Center, Rotterdam, The Netherlands. Electronic address:
    Atopic dermatitis is common and in its severe form is devastating. This chronic inflammatory dermatosis is part of the atopic syndrome, which includes asthma, food allergies, and hay fever and is known to be associated with mental health disorders. In line with psoriasis, several recent observational studies using national survey and linkage data have suggested a link between atopic dermatitis and cardiovascular disease. Read More

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