25,987 results match your criteria Atopic Dermatitis


The development of inflammatory arthritis and enthesitis in patients on dupilumab: a case series.

Br J Dermatol 2019 Apr 24. Epub 2019 Apr 24.

St. John's Institute of Dermatology, Guy's and St, Thomas' Hospital NHS Trust, Great Maze Pond, London, SE1 9RT.

Dupilumab (Dupixent , Sanofi), a fully human monoclonal antibody that blocks interleukin (IL)-4 and IL-13 signaling, is the first biologic approved in the UK for adult patients with moderate-to-severe atopic dermatitis (AD). In phase III studies, dupilumab was an effective treatment with 44-51% of patients achieving at least 75% improvement in Eczema Area and Severity Index (EASI). To date, dupilumab has been well tolerated; common adverse reactions reported from phase III data include injection-site reactions (8-19%), allergic conjunctivitis (3-19%) and oral herpes (2-5%). Read More

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http://dx.doi.org/10.1111/bjd.18031DOI Listing

Should we treat every infant with a probiotic?

Authors:
Mark A Underwood

Minerva Pediatr 2019 Jun;71(3):253-262

Division of Neonatology, University of California Davis, Sacramento, CA, USA -

Intestinal dysbiosis is associated with a long list of both acute and chronic inflammatory diseases and appears to be increasing in developed countries over the last century with the introduction of antibiotics, changes in sanitation, formula feeding and cesarean sections. The evidence supporting prophylactic administration of probiotic microbes to very preterm infants for the prevention of necrotizing enterocolitis, late onset sepsis and death is strong. The evidence for benefit of probiotics in infantile colic is strong but limited to the L. Read More

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http://dx.doi.org/10.23736/S0026-4946.19.05526-9DOI Listing

Asthma phenotypes and associated comorbidities in a large cohort of adolescents in Israel.

J Asthma 2019 Apr 24:1-14. Epub 2019 Apr 24.

a Medical Corps, IDF , Israel.

Objectives: Asthma is a multifactorial, heterogeneous, complex and common chronic respiratory disease driven by diverse mechanisms. Although asthma presents various clinical forms with different levels of severity, it is unclear whether asthma severities are a consequence of disease management or varied etiologies. We sought to investigate this question. Read More

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http://dx.doi.org/10.1080/02770903.2019.1604743DOI Listing

Clinical Efficacy of Allergen-Specific Immunotherapy from Patient and Physician Perspectives.

Yonsei Med J 2019 May;60(5):446-453

Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea.

Purpose: Allergen-specific immunotherapy (AIT) is the only curative treatment for allergic diseases, but a few allergic patients receive AIT. In this multicenter cross-sectional study, we aimed to explore patient and physician perspectives on AIT through a questionnaire survey.

Materials And Methods: Allergic patients who received subcutaneous immunotherapy for at least 1 year were asked to answer a questionnaire developed by an expert panel of allergen and immunotherapy workgroup in Korea. Read More

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http://dx.doi.org/10.3349/ymj.2019.60.5.446DOI Listing

Long-term effect of methotrexate for childhood atopic dermatitis.

J Paediatr Child Health 2019 Apr 23. Epub 2019 Apr 23.

Department of Paediatric Dermatology, Starship Children's Health, Auckland City Hospital, Auckland, New Zealand.

Aim: To evaluate methotrexate (MTX) for paediatric atopic dermatitis (AD) while on and post-treatment.

Methods: Medical records of children prescribed MTX for AD between 2011 and 2016 at Starship Children's Hospital, Auckland, New Zealand, were reviewed for demographics, dose and duration of MTX and hospitalisations for AD. In the follow-up by telephone in 2017, parents of the patients reported response on MTX, AD relapses and use of additional systemic treatment and completed a patient-oriented eczema measure (POEM). Read More

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http://dx.doi.org/10.1111/jpc.14478DOI Listing

[Risk factors for uncontrolled asthma in adults].

Rev Alerg Mex 2019 Jan-Mar;66(1):65-75

Secretaría de Salud, Hospital General de México, Servicio de Alergia e Inmunología Clínica, Ciudad de México, México.

Background: Many studies in children had identified risk factors associated with partly or uncontrolled asthma. In adults, factors related to asthma control were not well defined.

Objective: To find the factors related to partly or uncontrolled asthma in adults. Read More

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http://dx.doi.org/10.29262/ram.v66i1.557DOI Listing

Elevated levels of periostin and TGF-β1 in the bronchoalveolar lavage fluid of patients with idiopathic eosinophilic pneumonia.

Asian Pac J Allergy Immunol 2019 Apr 23. Epub 2019 Apr 23.

Department of Respiratory Medicine, Kawasaki Medical School, Okayama.

Background: Periostin is induced in bronchial epithelial cells and fibroblasts by various stimuli including interleukin (IL)13 and transforming growth factor (TGF)-β1, and is involved in allergic diseases such as asthma and atopic dermatitis, playing an important role in tissue remodeling and fibrosis. The role of periostin in the pathogenesis of eosinophilic lung diseases, however, is unclear.

Objective: To examine the contribution of periostin to eosinophilic inflammation of the lung in humans, we evaluated periostin, IL-13, and TGF-β1 levels in the bronchoalveolar lavage fluid (BALF) of patients with eosinophilic pneumonia (EP). Read More

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http://dx.doi.org/10.12932/AP-111018-0414DOI Listing

Patients with atopy exhibit reduced cortisol awakening response but not cortisol concentrations during the rest of the day.

Immunol Res 2019 Apr 22. Epub 2019 Apr 22.

Laboratory of Pharmacological Neuroendocrinology, Institute of Experimental Endocrinology, Biomedical Research Center of the Slovak Academy of Sciences, Bratislava, Slovakia.

It has been documented that cortisol release in response to acute stressors is reduced in patients with atopic dermatitis, allergic rhinitis, and other atopic diseases compared to that in healthy subjects. We aimed to test the hypothesis that atopic patients exert reduced salivary cortisol awakening response (CAR) in comparison with healthy subjects. The hypothesis was tested on a stressful and a relax day selected subjectively. Read More

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http://dx.doi.org/10.1007/s12026-019-09076-wDOI Listing

Infective dermatitis: A purely cutaneous manifestation of HTLV-1 infection.

Semin Diagn Pathol 2019 Apr 17. Epub 2019 Apr 17.

Dermatology and Pathology, Universidad Peruana Cayetano Heredia, Attending physican, Pathology service, Hospital Cayetano Heredia, Angamos 896 Miraflores, Lima 18, Peru. Electronic address:

Infectious dermatitis is a cutaneous manifestation of HTLV-1 infection. Although initially described in children in Jamaica, it is well documented that the disease can also present in adults. The clinical picture is of an oozing dermatitis affecting the scalp, face, retroauricular areas, the neck, and intertrigious areas, such as the axilla and groin. Read More

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http://dx.doi.org/10.1053/j.semdp.2019.04.002DOI Listing

Research Techniques Made Simple: Mouse Models of Atopic Dermatitis.

J Invest Dermatol 2019 May 19;139(5):984-990.e1. Epub 2019 Apr 19.

Cutaneous Leukocyte Biology Section, Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Disease, National Institutes of Health, Bethesda, Maryland, USA. Electronic address:

Atopic dermatitis (AD) is a common, chronic inflammatory skin disease characterized by impaired barrier function, eczematous dermatitis, and chronic pruritus. Mouse models have been heavily used to deepen our understanding of complicated disease mechanisms in AD and to provide a preclinical platform before performing clinical interventional research on novel therapeutic agents in humans. However, what aspects of human AD these mouse AD models faithfully recapitulate is insufficiently understood. Read More

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http://dx.doi.org/10.1016/j.jid.2019.02.014DOI Listing

SCIT Versus SLIT: Which One Do You Recommend, Doc?

Am J Med Sci 2019 May 10;357(5):442-447. Epub 2019 Feb 10.

Department of Otolaryngology, Emory University, Atlanta, Georgia.

Allergic rhinitis is a prevalent condition that has a significant impact on the quality of life of many patients. When initial therapy fails to control the symptoms, allergen immunotherapy (AIT) has been suggested as an option by the Joint Task Force on Practice Parameters. The 2 main forms of AIT are via subcutaneous and sublingual routes, called subcutaneous immunotherapy and sublingual immunotherapy, respectively. Read More

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http://dx.doi.org/10.1016/j.amjms.2019.02.004DOI Listing

The blood proteomic signature of early-onset pediatric atopic dermatitis shows systemic inflammation and is distinct from adult, longstanding disease.

J Am Acad Dermatol 2019 Apr 19. Epub 2019 Apr 19.

Department of Dermatology, Northwestern University Feinberg School of Medicine, 676 North St. Clair Street, Chicago, IL 60611, USA. Electronic address:

Background: Despite increasing evidence that adults with longstanding atopic dermatitis (AD) have systemic inflammation, little is known about systemic inflammation in recent-onset early pediatric AD.

Objective: To analyze blood inflammatory proteins of early pediatric AD.

Methods: Using high-throughput proteomics (proximity extension assay), we assessed 257 inflammatory and cardiovascular risk proteins in blood of 30 children with moderate-to-severe AD <5 years of age (within 6 months of onset), compared to age-matched pediatric controls and adult AD. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.04.036DOI Listing

Validation and interpretation of short form 12 and comparison with dermatology life quality index in atopic dermatitis in adults.

J Invest Dermatol 2019 Apr 19. Epub 2019 Apr 19.

Oregon Health & Science University, Portland, OR.

Quality of life (QOL) assessments are not standardized in atopic dermatitis (AD). We sought to determine the validity of Short-Form 12 (SF-12), a generic QOL assessment, in AD and compare its measurement properties with Dermatology Life Quality Index (DLQI). A cross-sectional, population-based study of 3495 adults was performed, including 602 that met a modified UK Working Party Criteria for AD. Read More

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http://dx.doi.org/10.1016/j.jid.2019.03.1152DOI Listing

Janus kinase inhibition in Down syndrome: 2 cases of therapeutic benefit for alopecia areata.

JAAD Case Rep 2019 Apr 5;5(4):365-367. Epub 2019 Apr 5.

Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

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http://dx.doi.org/10.1016/j.jdcr.2019.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453941PMC

Skin microdialysis: methods, applications and future opportunities-an EAACI position paper.

Clin Transl Allergy 2019 10;9:24. Epub 2019 Apr 10.

3Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.

Skin microdialysis (SMD) is a versatile sampling technique that can be used to recover soluble endogenous and exogenous molecules from the extracellular compartment of human skin. Due to its minimally invasive character, SMD can be applied in both clinical and preclinical settings. Despite being available since the 1990s, the technique has still not reached its full potential use as a tool to explore pathophysiological mechanisms of allergic and inflammatory reactions in the skin. Read More

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http://dx.doi.org/10.1186/s13601-019-0262-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456961PMC

Anti-Atopic Dermatitis Effect of Extract via Inhibiting the STAT1 Pathway.

Mediators Inflamm 2019 17;2019:3760934. Epub 2019 Mar 17.

Department of Pharmacology, College of Korean Medicine, Sangji University, Wonju-si, Gangwon-do 26339, Republic of Korea.

(SF) is a green alga rich in chlorophyll with unique flavor and taste. It is also called Maesaengi which has antioxidant and other physiological activities. In the present study, we evaluated the therapeutic effects of SF in a mouse model of body-induced atopic dermatitis (AD) and in tumor necrosis factor- and interferon--stimulated HaCaT keratinocytes. Read More

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http://dx.doi.org/10.1155/2019/3760934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441517PMC

Effectiveness of an antenatal maternal supplementation with prebiotics for preventing atopic dermatitis in high-risk children (the PREGRALL study): protocol for a randomised controlled trial.

BMJ Open 2019 Apr 20;9(4):e024974. Epub 2019 Apr 20.

Department of Dermatology, Centre Hospitalier Universitaire de Nantes, Nantes, Pays de la Loire, France.

Introduction: Atopic dermatitis (AD) is a chronic inflammatory disease affecting 10%-15% of children in Europe. There is a need for new primary preventive therapeutic strategies in at-risk populations. Recent research has indicated that atopic diseases are associated with a disrupted gut microbial 'balance' in early life raising the possibility that interventions which yield optimal patterns of microflora could improve host's health. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02497
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http://dx.doi.org/10.1136/bmjopen-2018-024974DOI Listing
April 2019
1 Read

Nanoemulsion strategy of pioglitazone for the treatment of skin inflammatory diseases.

Nanomedicine 2019 Apr 17. Epub 2019 Apr 17.

Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, 08028 Barcelona, Spain; Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, Granada, Spain. Electronic address:

Pioglitazone (PGZ) is a peroxisome proliferator-activated receptor agonist. Its role in the inflammatory response modulation opens the door for additional therapeutic applications. The purpose of this study was to develop a pioglitazone nanoemulsion (PGZ-NE) to investigate its anti-inflammatory efficacy on the skin. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15499634193007
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http://dx.doi.org/10.1016/j.nano.2019.03.017DOI Listing
April 2019
1 Read

The impact of recent advances in lipidomics and redox lipidomics on dermatological research.

Free Radic Biol Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Dermatology, Medical University of Vienna, Austria; Christian Doppler Laboratory for the Biotechnology of Skin Aging, Vienna, Austria.

Dermatological research is a major beneficiary of the rapidly developing advances in lipid analytic technology and of bioinformatic tools which help to decipher and interpret the accumulating big lipid data. At its interface with the environment, the epidermis develops a blend of lipids that constitutes the epidermal lipid barrier, essential for the protection from water loss and entry of dangerous noxae. Apart from their structural role in the barrier, novel intra- and inter-cellular signaling functions of lipids and their oxidation products have been uncovered in most cutaneous cell types over the last decades, and the discovery rate has been boosted by the advent of high resolution and -throughput mass spectrometric techniques. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08915849193015
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http://dx.doi.org/10.1016/j.freeradbiomed.2019.04.019DOI Listing
April 2019
1 Read

Evaluating crisaborole as a treatment option for atopic dermatitis.

Expert Opin Pharmacother 2019 Apr 19:1-7. Epub 2019 Apr 19.

d Department of Dermatology , Wake Forest School of Medicine , Winston-Salem , NC , USA.

Introduction: Atopic dermatitis (AD) is a chronic and recurrent disease presenting with eczematous lesions and pruritus. It impacts patient and family quality of life, increases morbidity, and accounts for large health-care expenditures. Although nonpharmacologic, topical, and systemic treatments exist, management of AD remains challenging due to limited treatment options. Read More

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https://www.tandfonline.com/doi/full/10.1080/14656566.2019.1
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http://dx.doi.org/10.1080/14656566.2019.1604688DOI Listing
April 2019
3 Reads

Atopic Eczema: Burden of disease and individual suffering - Results from a large EU-Study in adults.

J Eur Acad Dermatol Venereol 2019 Apr 19. Epub 2019 Apr 19.

European Federation of Allergy and Airway Diseases Patient's Associations, Brussels, Belgium.

Background: Atopic eczema (AE, atopic dermatitis) is one the most common non-communicable inflammatory skin diseases affecting 1-5% of the adult population in Europe with marked impairment in quality of life. In spite of great progress in understanding the pathophysiology of disturbed skin barrier and immune deviation, AE still represents a problem in daily clinical practice. Furthermore, the true impact of AE on individual suffering is often not recognized. Read More

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http://dx.doi.org/10.1111/jdv.15634DOI Listing

Respiratory morbidity, atopy and asthma at school age in preterm infants aged 32-35 weeks.

Eur J Pediatr 2019 Apr 18. Epub 2019 Apr 18.

Paediatric Pneumology Unit, University Clinic Hospital, University of Valencia, Av Blasco Ibáñez, 17, 46010, Valencia, Spain.

Little is known about respiratory morbidity and asthma risk in preterm infants (PTIs) with a gestational age (GA) over 32 weeks. This was a prospective study carried out from birth to 7-8 years, comparing two groups: (a) PTIs (GAs 32 weeks + 1 day to 35 weeks + 0 days, without comorbidities) and (b) full-term infants (FTIs; GA ≥ 37 weeks). Risk and protective factors for bronchiolitis and asthma were identified. Read More

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http://link.springer.com/10.1007/s00431-019-03372-1
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http://dx.doi.org/10.1007/s00431-019-03372-1DOI Listing
April 2019
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Dead Sea Climatotherapy versus topical steroid treatment for Atopic Dermatitis children: long-term follow-up study.

J Dermatolog Treat 2019 Apr 17:1-19. Epub 2019 Apr 17.

c Dead Sea & Arava Science Center , Israel.

The aim of this study was to compare long-term results of 4 weeks Dead Sea Climatotherapy at the Deutsches Medizinisches Zentrum, Israel to those obtained by classical topical treatment for moderate-to-severe Atopic Dermatitis. Seventy-two children from the Czech Republic were divided into three groups of twenty-four and treated during 3 periods (March 2014, October 2014 and March 2015) with gradually increasing sun exposure during 28 consecutive days. Forty-four children were treated with steroid creams at the Department of Dermatovenereology, Third Faculty of Medicine, Charles University and University Hospital of Kralovske Vinohrady, Prague, Czech Republic. Read More

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http://dx.doi.org/10.1080/09546634.2019.1605138DOI Listing

Anaphylaxis after wheat ingestion in a patient with coeliac disease: two kinds of reactions and the same culprit food.

Eur J Gastroenterol Hepatol 2019 Apr 15. Epub 2019 Apr 15.

Pediatric Gastroenterology and Liver Unit, Department of Pediatrics, Sapienza University of Rome, Rome, Italy.

In recent years, the role of atopic dermatitis epidermal skin barrier defects in inducing a transcutaneous allergic sensitization is highly debated, possibly explaining why some children with eczema are sensitized to foods they have never eaten. In our specific situation, the association between coeliac disease and wheat allergy might be particularly harmful owing to unavoidable strict food avoidance. We describe the case of a young boy affected by coeliac disease who, after an occasional unexpected ingestion of gluten, experienced a complete anaphylactic reaction characterized by urticarial, labial angioedema, wheezing, and hypotension. Read More

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http://dx.doi.org/10.1097/MEG.0000000000001421DOI Listing
April 2019
2 Reads

A therapeutic effect of cbd-enriched ointment in inflammatory skin diseases and cutaneous scars.

Clin Ter 2019 Mar-Apr;170(2):e93-e99

Department of General Surgery and Surgical Specialties, University of Modena and Reggio Emilia Medical School, Surgical Clinic, Modena - Second Opinion Medical Network, Modena (MO), Italy.

Objective: To investigate the therapeutic effect of CBD-ointment administered on severe skin chronic diseases and/or on their outcome scars.

Methods: A spontaneous, anecdotal, retrospective study of 20 patients with two most frequent skin disorders: psoriasis (n: 5 patients), atopic dermatitis (n: 5) and resulting outcome scars (n: 10). The subjects were instructed to administer topical CBD-enriched ointment to lesioned skin areas twice daily for three months treatment. Read More

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http://dx.doi.org/10.7417/CT.2019.2116DOI Listing
April 2019
9 Reads

Use of Physcion to Improve Atopic Dermatitis-Like Skin Lesions through Blocking of Thymic Stromal Lymphopoietin.

Molecules 2019 Apr 15;24(8). Epub 2019 Apr 15.

Department of Food Science & Technology and Research Institute for Basic Science, Hoseo University, Chungnam 31499, Korea.

Physcion is well known for the treatment of carcinoma. However, the therapeutic effect of physcion on atopic dermatitis (AD) through the inhibition of thymic stromal lymphopoietin (TSLP) level remains largely unknown. In this study, we investigated the anti-AD effect of physcion using HMC-1 cells, splenocytes, and a murine model. Read More

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http://dx.doi.org/10.3390/molecules24081484DOI Listing

Translational drug discovery and development with the use of tissue-relevant biomarkers: towards more physiological relevance and better prediction of clinical efficacy.

Exp Dermatol 2019 Apr 16. Epub 2019 Apr 16.

Sanofi, Global Head of Immunology Therapeutic Research Area, 640 Memorial Drive, Cambridge, MA, 02139, USA.

Due to the clinical development of drugs such as secukinumab, ustekinumab and dupilumab, major changes have been achieved in the treatment of patients diagnosed with psoriasis and atopic dermatitis. In academia and the pharmaceutical industry, research is increasingly moving towards the development of bi-specific antibodies and multi-specific nanobodies, as there is a compelling need for new treatment modalities for patients suffering from auto-immune or malignant disease. The purpose of this review is to discuss aspects of translational drug development with a particular emphasis on indications such as psoriasis and atopic dermatitis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/exd.13942
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http://dx.doi.org/10.1111/exd.13942DOI Listing
April 2019
3 Reads

Phenotypic analysis of atopic dermatitis in children aged 1-12 months: elaboration of novel diagnostic criteria for infants in China and estimation of prevalence.

J Eur Acad Dermatol Venereol 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, Institute of Dermatology, Shanghai Jiaotong University School of Medicine.

Background: Atopic dermatitis (AD) is the most common skin disorder in infancy. However, the diagnosis and definite significance of infantile AD remains a debated issue.

Objective: To analyze the phenotypes of AD in infancy, to establish diagnostic criteria, and to estimate the prevalence of this condition in China. Read More

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http://dx.doi.org/10.1111/jdv.15618DOI Listing
April 2019
2 Reads

The role of Langerhans cells in pathologies of the skin.

Immunol Cell Biol 2019 Apr 15. Epub 2019 Apr 15.

Department of Pathology, Dunedin School of Medicine, University of Otago, P O Box 56, Dunedin, New Zealand.

Langerhans cells (LCs) are epidermal immune cells of myeloid origin. Although these cells were primarily thought to play a defensive role in the skin, evidence now indicates a diverse range of LC-mediated effects including relay of viral antigens in herpes simplex infection, recruitment of eosinophils in atopic dermatitis, and promotion of a Th17 response in Candida infection. LCs may have a protective or suppressive function in pathologies of the skin, with differing functions being driven by the skin milieu. Read More

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http://dx.doi.org/10.1111/imcb.12253DOI Listing
April 2019
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Direct assessment of skin epithelial barrier by electrical impedance spectroscopy.

Allergy 2019 Apr 16. Epub 2019 Apr 16.

Swiss Institute of Allergy and Asthma Research (SIAF), Davos, Switzerland.

Background: Many skin and mucosal inflammatory disorders, such as atopic dermatitis, have been associated with an impaired epithelial barrier function, which allows allergens, pollutants or microbes to enter the tissue and activate the immune response. The aim of this study was to establish a method to directly assess in vivo the epidermal barrier function by electrical impedance (EI) spectroscopy.

Methods: Mice epidermal barrier was damaged by epicutaneous application of proteases and cholera toxin and by tape stripping. Read More

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http://dx.doi.org/10.1111/all.13824DOI Listing
April 2019
2 Reads

Repeat patch testing in a patient with allergic contact dermatitis improved on dupilumab.

JAAD Case Rep 2019 Apr 3;5(4):336-338. Epub 2019 Apr 3.

Department of Dermatology, Stanford University School of Medicine, Redwood City, California.

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https://linkinghub.elsevier.com/retrieve/pii/S23525126193003
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http://dx.doi.org/10.1016/j.jdcr.2019.01.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447730PMC
April 2019
7 Reads

Immune and Inflammatory Reponses to Skin Infections.

Curr Dermatol Rep 2018 Dec 22;7(4):338-349. Epub 2018 Sep 22.

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

Purpose Of Review: There have been recent advances in our understanding of cutaneous immune responses to the important human skin pathogen, (). This review will highlight these insights into innate and adaptive immune mechanisms in host defense and cutaneous inflammation in response to skin infections.

Recent Findings: Antimicrobial peptides, pattern recognition receptors and inflammasome activation function in innate immunity as well as T cells and their effector cytokines play a key role in adaptive immunity against skin infections. Read More

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http://dx.doi.org/10.1007/s13671-018-0235-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461387PMC
December 2018
1 Read

A Pharmacological Review on L.: Focusing on Anti-Inflammatory, Anti- Oxidant, Immuno-Modulatory and Antitumor Activities.

J Pharmacopuncture 2019 Mar 31;22(1):7-15. Epub 2019 Mar 31.

Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran.

. (PO) or Purslane is an annual grassy plant that is distributed in many parts of the world, especially the tropical and subtropical areas. PO has some pharmacological properties such as analgesic, antibacterial, skeletal muscle-relaxant, wound-healing, anti- inflammatory and a radical scavenger. Read More

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http://dx.doi.org/10.3831/KPI.2019.22.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461301PMC
March 2019
1 Read

Food Allergen Sensitisation Patterns in Omani Patients with Allergic Manifestations.

Sultan Qaboos Univ Med J 2018 Nov 28;18(4):e483-e488. Epub 2019 Mar 28.

Department of Microbiology, Sultan Qaboos University Hospital, Muscat, Oman.

Objectives: This study aimed to evaluate the relationship between food allergen sensitisation patterns and allergic manifestations in Omani patients and highlight the importance of specific immunoglobulin E (IgE) testing.

Methods: This retrospective study included all patients referred due to allergic manifestations to the Sultan Qaboos University Hospital (SQUH), Muscat, Oman, from November 2012 to November 2016. Specific IgE blood testing was performed to determine sensitisation to common foods known to cause allergic reactions. Read More

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https://journals.squ.edu.om/index.php/squmj/article/view/299
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http://dx.doi.org/10.18295/squmj.2018.18.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443266PMC
November 2018
2 Reads

Testing an ectoin containing emollient for atopic dermatitis.

Curr Pediatr Rev 2019 Apr 15. Epub 2019 Apr 15.

Department of Paediatrics, The Chinese University of Hong Kong, Shatin. Hong Kong.

Aim: To describe the methodology in studying patient's acceptability and efficacy of an ectoin containing emollient for atopic dermatitis (AD) Methods: We described the methodology that we used in studying emollients and moisturizers, and patient acceptability of a group of AD patients before and following usage of an ectoin-containing proprietary emollient. These data were also compared with other emollients that we previously reported.

Results: 30 subjects (50% Male, Mean (SD) age: 9. Read More

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http://dx.doi.org/10.2174/1573396315666190415144244DOI Listing
April 2019
1 Read

Apigenin Inhibits IL-31 Cytokine in Human Mast Cell and Mouse Skin Tissues.

Molecules 2019 Apr 2;24(7). Epub 2019 Apr 2.

Department of Health Management, Jeonju University, Jeonju-si, Jeollabuk-do 55069, Korea.

IL-31 is a recently discovered cytokine that is produced not only in T-cells but also in mast cells. It is strongly implicated to play a key role in inflammatory diseases and in the pathogenesis of itch in atopic dermatitis. Apigenin, a flavonoid of plant origin has numerous biological applications. Read More

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https://www.mdpi.com/1420-3049/24/7/1290
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http://dx.doi.org/10.3390/molecules24071290DOI Listing
April 2019
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Microbiome of the Skin and Gut in Atopic Dermatitis (AD): Understanding the Pathophysiology and Finding Novel Management Strategies.

J Clin Med 2019 Apr 2;8(4). Epub 2019 Apr 2.

Department of Dermatology, Incheon St. Mary's Hospital, The Catholic University of Korea, Seoul 06591, Korea.

Atopic dermatitis (AD) is a long-standing inflammatory skin disease that is highly prevalent worldwide. Multiple factors contribute to AD, with genetics as well as the environment affecting disease development. Although AD shows signs of skin barrier defect and immunological deviation, the mechanism underlying AD is not well understood, and AD treatment is often very difficult. Read More

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http://dx.doi.org/10.3390/jcm8040444DOI Listing
April 2019
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Incidence, Risk Factors and Outcomes Among Children With Acute Flaccid Myelitis: A Population-based Cohort Study in a California Health Network Between 2011 and 2016.

Pediatr Infect Dis J 2019 Apr 10. Epub 2019 Apr 10.

Department of Pediatric Infectious Diseases, Kaiser Permanente Oakland Medical Center, Oakland, California.

Background: Acute flaccid myelitis (AFM) is defined as an acute onset of limb weakness with longitudinal spinal gray matter lesions. Reporting bias and misdiagnosis confound epidemiologic studies of AFM. We mitigated these confounders by using a large data set to assess AFM incidence, risk factors and outcomes in a fixed population. Read More

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http://dx.doi.org/10.1097/INF.0000000000002276DOI Listing
April 2019
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Hyponatremia secondary to severe atopic dermatitis in early infancy.

Pediatr Int 2019 Apr 15. Epub 2019 Apr 15.

Department of Allergy, Kanagawa Children's Medical Center, Yokohama, Japan.

Background: Infants with atopic dermatitis who developed hyponatremia and hyperkalemia with raised aldosterone level have been repeatedly described in Japanese domestic literatures. However, similar reports from other countries are scarce.

Methods: Including our experiences, we collected reports of atopic dermatitis complicated with hyponatremia (≤130 mEq/L), written either in English or in Japanese, to delineate the characteristics and to elucidate the pathophysiology of this condition. Read More

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http://dx.doi.org/10.1111/ped.13865DOI Listing
April 2019
3 Reads

Dietary habits in adult Japanese patients with atopic dermatitis.

J Dermatol 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Nippon Medical School Chiba Hokusoh Hospital, Inzai, Japan.

Dietary habits can modulate the pathogenesis of atopic dermatitis. We evaluated these habits in adult Japanese patients with atopic dermatitis using a validated, brief-type self-administered diet history questionnaire and compared the results to those of age- and sex-matched healthy controls. Patients with atopic dermatitis showed higher intakes of carbohydrate and potatoes and lower intakes of alcohol, niacin, meat and oils/fats compared with those of the healthy controls. Read More

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http://dx.doi.org/10.1111/1346-8138.14881DOI Listing
April 2019
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Biophysical Measurements and Ultrasonographic Findings in Chronic Dermatitis in Comparison with Uninvolved Skin.

Indian J Dermatol 2019 Mar-Apr;64(2):90-96

Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran.

Background: Nowadays noninvasive techniques are performed to evaluate the biophysical properties of skin .

Aims: The aim of this study was to evaluate the biophysical and ultrasonographic properties of skin in chronic contact or atopic dermatitis to provide better insight into pathogenesis, diagnosis, and treatment response.

Materials And Methods: The stratum corneum hydration, transepidermal water loss (TEWL), pH, erythema, melanin, sebum, friction, temperature, elasticity parameters (R0, R2, and R5), the thickness and echo-density of epidermis, dermis, and subepidermal low-echogenic band (SLEB) were measured on lesional, perilesional, and symmetrical skin of 22 chronic dermatitis patients. Read More

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http://dx.doi.org/10.4103/ijd.IJD_464_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440184PMC
April 2019
4 Reads

Sodium hypochlorite body wash in the management of Staphylococcus aureus-colonized moderate-to-severe atopic dermatitis in infants, children, and adolescents.

Pediatr Dermatol 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Objectives: A cleansing body wash containing diluted sodium hypochlorite (0.006% NaOCl) was evaluated for management of moderate-to-severe Staphylococcus aureus-colonized, atopic dermatitis in children.

Methods: A 6-week, prospective, open-label study was conducted with 50 evaluable participants (ages 6 months to 17 years) who had moderate-to-severe atopic dermatitis with S aureus skin colonization documented by culture. Read More

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http://dx.doi.org/10.1111/pde.13842DOI Listing
April 2019
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Identification of blood microRNA alterations in patients with severe active alopecia areata.

J Cell Biochem 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.

Background: Alopecia areata (AA) is a common inflammatory disease characterized by cellular infiltration of T cells targeting the anagen-stage hair follicle. Lack of efficacious treatment for AA may be due to little knowledge about its exact cellular mechanism. Studies have demonstrated that microRNAs (miRNAs) play an important role in the regulation of inflammatory skin diseases such as atopic dermatitis and psoriasis. Read More

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http://dx.doi.org/10.1002/jcb.28700DOI Listing
April 2019
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Efficacy and patient opinion of wet-wrap dressings using 0.1% triamcinolone acetonide ointment vs cream in the treatment of pediatric atopic dermatitis: A randomized split-body control study.

Pediatr Dermatol 2019 Apr 14. Epub 2019 Apr 14.

Dell Children's Medical Center, Austin, Texas.

Background: Wet wraps can be an effective means of improving atopic dermatitis (AD). Little research has been done regarding the comparative efficacy of topical steroid vehicles and patient preference.

Objective: This study aimed to compare the efficacy of 0. Read More

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http://dx.doi.org/10.1111/pde.13830DOI Listing

Infant milk-feeding practices and food allergies, allergic rhinitis, atopic dermatitis, and asthma throughout the life span: a systematic review.

Am J Clin Nutr 2019 Mar;109(Supplement_7):772S-799S

USDA, Food and Nutrition Service, Alexandria, VA.

Background: During the Pregnancy and Birth to 24 Months Project, the USDA and Department of Health and Human Services initiated a review of evidence on diet and health in these populations.

Objectives: The aim of these systematic reviews was to examine the relation of 1) never versus ever feeding human milk, 2) shorter versus longer durations of any human milk feeding, 3) shorter versus longer durations of exclusive human milk feeding prior to infant formula introduction, 4) feeding a lower versus higher intensity of human milk to mixed-fed infants, and 5) feeding a higher intensity of human milk by bottle versus breast with food allergies, allergic rhinitis, atopic dermatitis, and asthma.

Methods: The Nutrition Evidence Systematic Review team conducted systematic reviews with external experts. Read More

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http://dx.doi.org/10.1093/ajcn/nqy283DOI Listing
March 2019
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6.770 Impact Factor

Complementary feeding and food allergy, atopic dermatitis/eczema, asthma, and allergic rhinitis: a systematic review.

Am J Clin Nutr 2019 Mar;109(Supplement_7):890S-934S

USDA, Food and Nutrition Service, Alexandria, VA.

Background: Nutrition during infancy and toddlerhood may influence health and disease prevention across the life span. Complementary feeding (CF) starts when human milk or infant formula is complemented by other foods and beverages, beginning during infancy and continuing to age 24 mo.

Objectives: The aim of this study was to describe systematic reviews conducted for the USDA and the Department of Health and Human Services Pregnancy and Birth to 24 Months Project to answer the following question: What is the relationship between the timing of the introduction of complementary foods and beverages (CFBs), or types and amounts of CFBs consumed, and the development of food allergy, atopic dermatitis/eczema, asthma, and allergic rhinitis?

Methods: The literature was searched using 4 databases (CINAHL, Cochrane, Embase, PubMed) to identify articles published from January 1980 to February 2017 that met predetermined inclusion criteria. Read More

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http://dx.doi.org/10.1093/ajcn/nqy220DOI Listing
March 2019
3 Reads
6.770 Impact Factor

Soybean fermented with (Cheonggukjang) ameliorate atopic dermatitis-like skin lesion in mice by suppressing infiltration of mast cells and production of IL-31 cytokine in skin lesions.

J Microbiol Biotechnol 2019 Apr 12. Epub 2019 Apr 12.

Department of Health Management, Jeonju University, Jeonju, Jeonbuk 55069, Republic of Korea.

The present study was conducted with the aim to investigate the ameliorative effects of new soybean product (cheonggukjang) fermented with SCGB1 (SFBA) in atopic dermatitis (AD) mouse model. Visual evaluation of AD induction in the mice indicated a remarkable control of SFBA in reducing pathological severity of AD-like skin lesions reported as the SCORAD score of AD clinical symptoms. The results revealed that SFBA reduced dorsal skin and epidermal thickness to a similar extent with prednisolone. Read More

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http://dx.doi.org/10.4014/jmb.1812.12046DOI Listing
April 2019
3 Reads

Adherence to a novel home phototherapy system with integrated features.

Dermatol Online J 2019 Mar 15;25(3). Epub 2019 Mar 15.

Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, North Carolina.

Objective: To measure adherence using a novel home UVB phototherapy system designed to promote adherence.

Study Design: A retrospective, observational study conducted to evaluate patients' adherence to a prescribed three-times-per-week treatment protocol using a novel home phototherapy system with integrated features designed to improve adherence.

Methods: Data was collected from 18 psoriasis patients, 27 vitiligo patients, and three atopic dermatitis patients using a novel home phototherapy system under normal use conditions. Read More

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March 2019
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Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling.

Bioorg Med Chem Lett 2019 Apr 4. Epub 2019 Apr 4.

Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

Disruption of interleukin-13 (IL-13) signaling with large molecule antibody therapies has shown promise in diseases of allergic inflammation. Given that IL-13 recruits several members of the Janus Kinase family (JAK1, JAK2, and TYK2) to its receptor complex, JAK inhibition may offer an alternate small molecule approach to disrupting IL-13 signaling. Herein we demonstrate that JAK1 is likely the isoform most important to IL-13 signaling. Read More

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http://dx.doi.org/10.1016/j.bmcl.2019.04.008DOI Listing