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    1 OF 477

    Oral tolerance modulates the skin transcriptome in mice with induced atopic dermatitis.
    Allergy 2017 Nov 23. Epub 2017 Nov 23.
    Department of Microbiology, School of Medicine, Gachon University, Incheon, Korea.
    Defective gut immune reactions have been implicated in the development of atopic dermatitis (AD), whereas oral tolerance (OT), i.e., the immune unresponsiveness induced by oral antigen administration, protects mice against AD. Read More

    Association of prenatal folate status with early childhood wheeze and atopic dermatitis.
    Pediatr Allergy Immunol 2017 Nov 23. Epub 2017 Nov 23.
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
    Background: Prenatal folic acid supplementation is recommended to prevent birth defects. Some foods are fortified in the U.S. Read More

    Risk Factors for Asthma Occurrence in Children With Early-Onset Atopic Dermatitis: An 8-Year Follow-Up Study.
    Pediatr Allergy Immunol 2017 Nov 23. Epub 2017 Nov 23.
    Environmental and Occupational Medicine, National Taiwan University and National Taiwan University Hospital, Taipei, Taiwan.
    Background: Children with early-onset atopic dermatitis (AD) are at substantial risk of developing asthma later in life, and identifying the critical window of detrimental exposure is advantageous for implementing preventive actions. The aim of this study was to evaluate the role of exposure to environmental modifiers during pregnancy and early childhood in asthma occurrence in an infantile AD cohort.

    Methods: Eligible study participants were selected from the Taiwan Birth Cohort Study, which enrolled 24200 newborns in 2005. Read More

    Non-corticosteroid adherence and itch severity influence perception of itch in atopic dermatitis.
    J Dermatol 2017 Nov 23. Epub 2017 Nov 23.
    Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
    Topical corticosteroid phobia is an important problem in the treatment of atopic dermatitis as it can affect the ability to control disease severity and itch by reducing treatment adherence. Topical corticosteroid phobia often ends up even non-corticosteroid adherence. As such, non-corticosteroid adherence, disease severity and itch are likely to be associated with each other, but their relationship has yet to be thoroughly investigated. Read More

    Economic assessment of actual prescription of drugs for treatment of atopic dermatitis: Differences between dermatology and pediatrics in large-scale receipt data.
    J Dermatol 2017 Nov 23. Epub 2017 Nov 23.
    Department of Bio-Environmental Response, Dermatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
    Using large-scale receipt data, we analyzed the differences in the prescription of drugs and their costs between dermatology and pediatrics in the treatment of atopic dermatitis (AD) in children. Between August 2010 and July 2011, 50 706 patients were diagnosed as having AD, and the data of 21 075 (15 257 dermatology, 5818 pediatric) patients aged 0-14 years were included in this study. The use of classes I (strongest), II (very strong), and III (strong) topical corticosteroids and tacrolimus was significantly higher in dermatology than in pediatrics (class I, 2. Read More

    A randomized, open-label study to evaluate an intermittent dosing regimen of fluticasone propionate 0.05% cream in combination with regular emollient skin care in reducing the risk of relapse in pediatric patients with stabilized atopic dermatitis.
    J Dermatolog Treat 2017 Nov 22:1-9. Epub 2017 Nov 22.
    b GlaxoSmithKline , Rochester Park , Singapore.
    Background: Atopic dermatitis (AD) is a chronic, relapsing disease that requires maintenance treatment. This study examined the efficacy and safety of extended intermittent fluticasone propionate (FP) 0.05% cream, with emollient, vs emollient alone in children with AD. Read More

    A systematic review of ustekinumab in the treatment of atopic dermatitis.
    J Dermatolog Treat 2017 Nov 22:1-11. Epub 2017 Nov 22.
    a Department of Dermatology , The First Affiliated Hospital of Zhejiang University , Hangzhou , Zhejiang , 310000 , China.
    Ustekinumab is a human monoclonal IgG1 antibody targeting the p40 subunit shared by IL-12 and IL-23. We reviewed the published literature by searching from PubMed, EMBASE, Web of Science and to evaluate the efficacy and safety of ustekinumab in the treatment of AD. Read More

    Association of oxidative stress and dynamic thiol-disulphide homeostasis with atopic dermatitis severity and chronicity in children: a prospective study.
    Clin Exp Dermatol 2017 Nov 22. Epub 2017 Nov 22.
    Department of Pediatric Allergy and Immunology, Faculty of Medicine, Inonu University, Malatya, Turkey.
    Background: Oxidative stress (OS) has an important effect on the pathogenesis of atopic dermatitis (AD). Thiols are antioxidants that regulate intracellular redox metabolism and protect keratinocytes against OS damage in the stratum corneum.

    Aim: To investigate dynamic thiol-disulphide homeostasis (dTDH) as a novel OS parameter in children with AD, and its relationship with disease severity and chronicity. Read More

    Parasite-Derived Proteins for the Treatment of Allergies and Autoimmune Diseases.
    Front Microbiol 2017 7;8:2164. Epub 2017 Nov 7.
    Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
    The morbidity associated with atopic diseases and immune dysregulation disorders such as asthma, food allergies, multiple sclerosis, atopic dermatitis, type 1 diabetes mellitus, and inflammatory bowel disease has been increasing all around the world over the past few decades. Although the roles of non-biological environmental factors and genetic factors in the etiopathology have been particularly emphasized, they do not fully explain the increase; for example, genetic factors in a population change very gradually. Epidemiological investigation has revealed that the increase also parallels a decrease in infectious diseases, especially parasitic infections. Read More

    Molecular mechanisms of anti-inflammatory effect of chrysophanol, an active component of AST2017-01 on atopic dermatitis in vitro models.
    Int Immunopharmacol 2017 Nov 18;54:238-244. Epub 2017 Nov 18.
    Department of Pharmacology, College of Korean Medicine, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea. Electronic address:
    AST2017-01 mainly consists of Rumex crispus and -Cordyceps militaris and has been widely consumed as an herbal medicine or functional food in Korea. Here we investigated the influences of AST2017-01 and its active component, chrysophanol on human mast cell (HMC-1 cell) and human keratinocyte (HaCaT cell)-mediated inflammatory reactions. Pretreatment with AST2017-01 or chrysophanol suppressed intracellular calcium levels and histamine release in phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-treated HMC-1 cells. Read More

    Potential treatment of atopic dermatitis: tolerability and safety of cream containing nanoparticles loaded with hydrocortisone and hydroxytyrosol in human subjects.
    Drug Deliv Transl Res 2017 Nov 20. Epub 2017 Nov 20.
    Department of Pathology, University of Veterinary and Animal Sciences, Lahore, Pakistan.
    Hydrocortisone (HC), topical glucocorticoid along with hydroxytyrosol (HT), and anti-microbial- and anti-oxidant-loaded chitosan nanoparticles (CSNPs) were prepared in large scale and analyzed for their adverse effects on healthy human skin followed by repeated applications. Ten subjects were randomized to receive test (HC-HT CSNPs) and vehicle samples (aqueous (AQ) cream). They were applied on the arms for 28 days, and transepidermal water loss (TEWL), erythema intensity, and irritation score were measured. Read More

    Prevalence of papular urticaria caused by flea bites and associated factors in children 1-6 years of age in Bogotá, D.C.
    World Allergy Organ J 2017 7;10(1):36. Epub 2017 Nov 7.
    Allergy Section, Hospital Universitario Fundación Santa Fe de Bogotá, Faculty of Medicine, Universidad de los Andes, Bogotá, Colombia.
    Background: Papular urticaria is a chronic inflammatory disease caused by exposure to arthropod bites. The disease has been reported in children attending medical centers, but the causes as the risk factors associated with the disease have not been established. The objective of this study was to determine the prevalence of papular urticaria caused by flea bite and identify the risk factors in children between 1 to 6 years of age in Bogotá D. Read More

    Anti-allergic effects of sesquiterpene lactones from Saussurea costus (Falc.) Lipsch. determined using in vivo and in vitro experiments.
    J Ethnopharmacol 2017 Nov 17. Epub 2017 Nov 17.
    Molecular Inflammation Research Center for Aging Intervention (MRCA) and College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea. Electronic address:
    Ethnopharmacological Relevance: Saussurea costus (Falc.) Lipsch. root has been used in Asian traditional medicine for the treatment of asthma, rheumatism, and other conditions. Read More

    RNase 7 strongly promotes TLR9-mediated DNA sensing by human plasmacytoid dendritic cells.
    J Invest Dermatol 2017 Nov 17. Epub 2017 Nov 17.
    Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Germany.
    Plasmacytoid dendritic cells (pDCs) were described to accumulate in the skin of patients with psoriasis and to be recruited into the dermis upon allergen challenge in atopic dermatitis. Importantly, activation of pDCs in the skin has been identified as important initiator of psoriasis development. RNase 7 is one of the major antimicrobial peptides (AMP) secreted by keratinocytes and is expressed in significantly higher amounts in lesional skin of patients with atopic dermatitis or psoriasis than in healthy individuals. Read More

    The prevention of TNF-α/IFN-γ mixture-induced inflammation in human keratinocyte and atopic dermatitis-like skin lesions in Nc/Nga mice by mineral-balanced deep sea water.
    Biomed Pharmacother 2017 Nov 14;97:1331-1340. Epub 2017 Nov 14.
    Department of Pharmacology and Intractable Disease Research Center, School of Medicine, Dongguk University, Gyeongju, 38066, Republic of Korea. Electronic address:
    Atopic dermatitis (AD) is a chronic inflammatory skin disease caused by environmental and chemical allergens. Despite the complexity of its pathogenesis, many investigations have shown that substances having anti-inflammatory activities alleviated the pathology of AD. Here, we evaluated the effects of mineral-balanced deep sea water (DSW) on AD-like skin damage in both in vitro and in vivo. Read More

    Patients with atopic dermatitis and history of eczema herpeticum elicit HSV-specific type 2 immune responses.
    J Allergy Clin Immunol 2017 Nov 15. Epub 2017 Nov 15.
    Department of Dermatology and Allergy, Division of Immunodermatology and Allergy Research, Hannover Medical School, Hannover, Germany.
    An increased type 2 and in parallel decreased type 1 T cell immune response to herpes simplex virus 1 may lead to the clinical phenotype of eczema herpeticum. Read More

    A new topical treatment of atopic dermatitis in pediatric patients based on Ficus carica L. (Fig): A randomized, placebo-controlled clinical trial.
    Complement Ther Med 2017 Dec 13;35:85-91. Epub 2017 Oct 13.
    Pharmacological Research Center of Medicinal Plants, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:
    Background: Atopic dermatitis (AD) is a common, chronic, relapsing and inflammatory skin disease characterized by pruritus and xerosis (dry skin). Its prevalence is on the increase worldwide, particularly in children. As the pathogenesis of AD involves a complex interaction of genetic, environmental and immunological factors, its definitive treatment is difficult. Read More

    Predicting the atopic march: Results from the Canadian Healthy Infant Longitudinal Development Study.
    J Allergy Clin Immunol 2017 Nov 1. Epub 2017 Nov 1.
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada. Electronic address:
    Background: The atopic march describes the progression from atopic dermatitis during infancy to asthma and allergic rhinitis in later childhood. In a Canadian birth cohort we investigated whether concomitant allergic sensitization enhances subsequent development of these allergic diseases at age 3 years.

    Methods: Children completed skin prick testing at age 1 year. Read More

    Barrier dysfunction in the skin allergy.
    Allergol Int 2017 Nov 16. Epub 2017 Nov 16.
    Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Singapore Immunology Network (SIgN) and Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore; PRESTO, Japan Science and Technology Agency, Saitama, Japan. Electronic address:
    The skin is continuously exposed to external pathogens, and its barrier function is critical for skin homeostasis. Previous studies have shown that the barrier dysfunction is one of the most predisposing factors for the development of skin allergic diseases such as atopic dermatitis. In this article, we summarize how the physical barrier of the skin is organized and review its link to the pathomechanism of skin allergic diseases. Read More

    Pathophysiology of IL-33 and IL-17 in allergic disorders.
    Cytokine Growth Factor Rev 2017 Nov 11. Epub 2017 Nov 11.
    Food Toxicology Laboratory; Food, Drug and Chemical Toxicology Group; CSIR-Indian Institute of Toxicology Research (CSIR-IITR); Vishvigyan Bhawan; 31; Mahatma Gandhi Marg; Lucknow 226 001; Uttar Pradesh; India. Electronic address:
    Allergic diseases are among common clinical conditions, affecting millions of children and adults throughout the world. Food allergies, skin allergies (atopic dermatitis), and respiratory allergies (allergic rhinitis and asthma) are the common types of allergies. Recently discovered cytokines IL-17 and IL-33 have been found to play an important role in the pathogenicity of various hypersensitive disorders. Read More

    Risk Factors in Preschool Children for Predicting Asthma During the Preschool Age and the Early School Age: a Systematic Review and Meta-Analysis.
    Curr Allergy Asthma Rep 2017 Nov 18;17(12):85. Epub 2017 Nov 18.
    Department of Pediatrics, Shanghai General Hospital, Shanghai Jiaotong University, No. 100, Haining Road, Hongkou District, Shanghai, 200080, China.
    Purpose Of Review: The aim of this study was to identify risk factors of asthma among children < 6 years old (preschool age) for predicting asthma during the preschool age and early school age (≤ 10 years of age).

    Method Of The Study: MEDLINE, Cochrane, EMBASE, and Google Scholar databases were searched until June 30, 2017. Prospective or retrospective cohort and case-control studies were included. Read More

    Poor agreement in questionnaire-based diagnostic criteria for adult atopic dermatitis is a challenge when examining cardiovascular comorbidity.
    Allergy 2017 Nov 18. Epub 2017 Nov 18.
    Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
    Background: The association between atopic dermatitis (AD) and cardio-metabolic risk factors is not yet established. Furthermore, no validated questionnaire-based method of identifying adults with AD is currently available.

    Objectives: To assess the cardio-metabolic risk in adults with a history of AD by using three different questionnaire-based diagnostic criteria. Read More

    Barrier dysfunction in the nasal allergy.
    Allergol Int 2017 Nov 14. Epub 2017 Nov 14.
    Department of Immunology, Hyogo College of Medicine, Hyogo, Japan; Laboratory of Allergic Diseases, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Hyogo, Japan. Electronic address:
    Epithelial cells form the first physiological barrier against invasion by pathogens and the infiltration of allergens. Tight junctions (TJ), a cell-cell junctional complex located on the apical side of epithelial cells, have a critical role in the maintenance of epithelial barrier function. Impaired TJ structures are observed in patients with asthma, atopic dermatitis and nasal allergy; therefore, the dysfunction of epithelial barriers might be involved in the initiation or progression of allergic diseases. Read More

    Efficacy of bleach baths in reducing severity of atopic dermatitis: A systematic review and meta-analysis.
    Ann Allergy Asthma Immunol 2017 Nov;119(5):435-440
    Department of Dermatology, Preventive Medicine and Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Northwestern Medicine Multidisciplinary Eczema Center, Chicago, Illinois. Electronic address:
    Background: Bleach baths have been proposed as a treatment for decreasing the severity of atopic dermatitis (AD). However, conflicting results have been found regarding their efficacy.

    Objective: To determine the efficacy of bleach vs water baths at decreasing AD severity. Read More

    Testing Actions of a Multi-action Emollient: Patient Acceptability, Efficacy, Skin Biophysiology and Staphylococcal Isolation.
    Curr Pediatr Rev 2017 Nov 16. Epub 2017 Nov 16.
    Department of Pediatrics, The Chinese University of Hong Kong, 6/F, Clinical Science Building, Prince of Wales Hospital, Shatin. Hong Kong.
    Aim: Eczema or atopic dermatitis (AD) is associated with itch, sleep disturbance, impaired life quality, reduced skin hydration, impaired epidermal barrier function and colonization by Staphylococcus aureus (SA). We investigated an emollient with claimed multi-actions on barrier repair, antihistaminergic and antimicrobial effects.

    Methods: Consecutive AD patients were recruited. Read More

    Characterization of children with recurrent eczema herpeticum and response to treatment with interferon-gamma.
    Pediatr Dermatol 2017 Nov;34(6):686-689
    Saint Louis University Hospital, St. Louis, MO, USA.
    Background/objectives: Interferon gamma (IFN-γ) has been used treat severe atopic dermatitis, with equivocal results. Recurrent eczema herpeticum is an underappreciated, therapeutically challenging complication of severe atopic dermatitis. Defects in IFN-γ and other cytokine pathways have been identified in individuals with confirmed eczema herpeticum. Read More

    Analysis of anti-TNF-induced skin lesions reveals strong Th1 activation with some distinct immunological characteristics.
    Br J Dermatol 2017 Nov 16. Epub 2017 Nov 16.
    Department of Dermatology, Division of Immunology, Allergy and Infectious Diseases, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
    Background: Psoriasiform and eczematous eruptions are the most common dermatological adverse reaction linked to anti-TNF-α therapy. Yet, a detailed characterization of their immune phenotype is lacking.

    Objectives: We sought to characterize anti-TNF-α induced inflammatory skin lesions on a histopathologic, cellular and molecular level, compared to psoriasis, eczema (atopic dermatitis), and healthy control skin. Read More

    Prolonging Time to Flare in Pediatric Atopic Dermatitis: A Randomized, Investigator-Blinded, Controlled, Multicenter Clinical Study of a Ceramide-Containing Moisturizer.
    Adv Ther 2017 Nov 16. Epub 2017 Nov 16.
    Galderma R&D, Sophia Antipolis, France.
    Introduction: Delaying or preventing flares is important in atopic dermatitis (AD) management. The objective of the study was to evaluate whether using a ceramide-containing moisturizer in addition to a body wash during latent AD can delay flares.

    Methods: This was a randomized, investigator-blinded, parallel-group, controlled study among Chinese children with a history of mild to moderate AD, within 1 week of successful treatment with a topical corticosteroid. Read More

    Patterns of allergic sensitization and atopic dermatitis from 1 to 3 years: effects on allergic diseases.
    Clin Exp Allergy 2017 Nov 16. Epub 2017 Nov 16.
    Department of Medicine, McMaster University, Hamilton, Canada.
    Background: While allergic sensitization and atopic dermatitis (AD) are known to increase the risk for allergic diseases, the impact of different temporal and clinical patterns of sensitization and AD is less well defined.

    Objective: We investigated patterns of sensitization and AD from early infancy to age 3, and the differential risk for developing allergic diseases within each pattern in a general cohort.

    Methods: Children (n=2629) from the Canadian Healthy Infant Longitudinal Development (CHILD) Study underwent skin prick tests and were assessed clinically for AD at ages 1 and 3 years. Read More

    Patch testing in Israeli children with suspected allergic contact dermatitis: A retrospective study and literature review.
    Pediatr Dermatol 2017 Nov 16. Epub 2017 Nov 16.
    Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
    Background/objectives: Childhood allergic contact dermatitis is recognized as a significant clinical problem. The objective was to evaluate the rate of positive patch tests in Israeli children with clinically suspected allergic contact dermatitis, identify possible sex and age differences, compare results with those in Israeli adults, and review pediatric studies in the literature.

    Methods: The study sample included 343 children and adolescents (197 female, 146 male; 1-18 years of age, mean age 11. Read More

    Use of Isoquercetin in the Treatment of Prurigo Nodularis.
    J Drugs Dermatol 2017 Nov;16(11):1156-1158

    Atopic dermatitis and prurigo nodularis result from complex interactions between the skin, the immune system, and the external environment. The pruritus associated with these conditions greatly impacts patients' quality of life and lacks uniformly effective treatment. A 57-year-old patient presented with severe atopic dermatitis and subsequent prurigo nodularis refractory to numerous standard therapies. Read More

    A Guide to Topical Vehicle Formulations.
    J Cutan Med Surg 2017 Nov 1:1203475417743234. Epub 2017 Nov 1.
    2 Queen's University, Kingston, ON, Canada.
    Adherence to topical treatment for a variety of chronic skin conditions, such as psoriasis, acne, and atopic dermatitis, is known to be very poor. A number of factors contribute to this phenomenon, including lack of treatment efficacy and patient concerns regarding side effects, among others. At the forefront of barriers facing optimal patient adherence to topical treatment is choosing the ideal topical vehicle formulation. Read More

    Author's response to the comment to 'Compound heterozygotes for filaggrin gene mutations do not always show severe atopic dermatitis'.
    J Eur Acad Dermatol Venereol 2017 Nov 14. Epub 2017 Nov 14.
    Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan.
    FLG mutations play a causal role in the development of ichthyosis vulgaris (IV) and are known to be a predisposing factor for atopic dermatitis (AD) in European and Asian populations. However, it remains a matter of debate how loss of function of filaggrin leads to AD. Skin barrier dysfunction due to the loss of structural proteins in the epidermis makes it easy for allergens to invade, and sensitization to the allergens, increases in serum IgE, and dermatitis follow. Read More

    Comments to: Compound heterozygotes for filaggrin gene mutations do not always show severe atopic dermatitis.
    J Eur Acad Dermatol Venereol 2017 Nov 14. Epub 2017 Nov 14.
    Dermatology Unit / Department of Clinical Medicine, A.O.U.P./ Università degli Studi di Napoli Federico II via S.Pansini, 5 80121, Napoli, Italy.
    recent paper by Akiyama and coworkers questions one more time about role of FLG in A.D.Since first reports of heterozygous mutations of FLG in A. Read More

    Novel topical agent containing superoxide dismutase 100 000 IU and 4% of plant extracts as a mono-therapy for atopic dermatitis.
    J Cosmet Dermatol 2017 Nov 13. Epub 2017 Nov 13.
    2nd Department of Dermatology-Venereology, National Kapodistrian University of Athens Medical School, ATTIKON University Hospital, Athens, Greece.
    Introduction: Corticosteroids are the mainstay of treatment for the acute phase of atopic dermatitis (AD), whereas topical emollients are mainly used for maintenance of remission. A topical agent that combines emollient and anti-inflammatory properties would achieve control of all phases of AD, without the need for chronic corticosteroid use.

    Aim: To assess the efficacy of a novel topical agent containing superoxide dismutase (SOD) 100 000 IU and 4% of a combination of plant extracts (blackcurrant seed oil, sunflower oil concentrate, balloon vine extract). Read More

    Examining the association between maternal atopy and birth outcomes using a retrospective cohort in the southeastern region of the USA.
    BMJ Open 2017 Nov 12;7(11):e017161. Epub 2017 Nov 12.
    Department of Family and Community Medicine, Baylor College of Medicine, Houston, Texas, USA.
    Objective: To assess birth outcomes in primiparous women with diagnosis of non-asthmatic atopy (NAA). Researchers hypothesised that women with NAA would have reduced the risk of adverse birth outcomes compared with women without NAA. NAA is defined as having allergic rhinitis and/or atopic dermatitis. Read More

    Phenotypical Differences of Childhood- and Adult-Onset Atopic Dermatitis.
    J Allergy Clin Immunol Pract 2017 Nov 10. Epub 2017 Nov 10.
    Department of Dermatology, Feinberg School of Medicine at Northwestern University, Chicago, Ill.
    Background: Little is known about adult-onset atopic dermatitis (AD).

    Objective: To determine the associations and clinical characteristics of adult-onset AD.

    Methods: A prospective study of 356 adults with AD (age ≥18 years) was performed using standardized questionnaires and examination. Read More

    Effect of an Intervention to Promote Breastfeeding on Asthma, Lung Function, and Atopic Eczema at Age 16 Years: Follow-up of the PROBIT Randomized Trial.
    JAMA Pediatr 2017 Nov 13:e174064. Epub 2017 Nov 13.
    Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts.
    Importance: Atopic diseases, including asthma and atopic eczema, are the most common chronic conditions of childhood.

    Objective: To investigate whether an intervention to promote prolonged and exclusive breastfeeding protects against asthma, atopic eczema, and low lung function in adolescence.

    Design, Setting, And Participants: Follow-up of the Promotion of Breastfeeding Intervention Trial (PROBIT), a cluster randomized trial in 30 Belarusian maternity hospitals and affiliated polyclinics; recruitment of 17 046 healthy term infants took place from June 15, 1996, to December 31, 1997. Read More

    Extent and consequences of inadequate disease control among adults with a history of moderate to severe atopic dermatitis.
    J Dermatol 2017 Nov 13. Epub 2017 Nov 13.
    Sanofi, New Jersey, USA.
    Since control of atopic dermatitis (AD) remains challenging but has not been adequately characterized, the objective of this study was to characterize disease control among patients with a history of moderate to severe AD. Data were from the 2014 Adelphi US AD Disease Specific Programme, a cross-sectional survey of physicians (n = 202) and their patients with history of moderate to severe AD (n = 1064, 54% female, 75% white, mean age 40 years). Inadequately controlled AD as rated by the physician was defined as currently flaring; deteriorating/changeable AD; or physician dissatisfaction with current control. Read More

    Identification of atopic dermatitis subgroups in children from two longitudinal birth cohorts.
    J Allergy Clin Immunol 2017 Nov 9. Epub 2017 Nov 9.
    Skin Research Group, School of Medicine, University of Dundee, Dundee, DD1 9SY Scotland, UK; Department of Dermatology, Ninewells Hospital, Dundee, DD1 9SY Scotland, UK.
    Background: Atopic dermatitis (AD) is a prevalent disease with variable natural history. Longitudinal birth cohort studies provide an opportunity to define subgroups based on disease trajectories, which may represent different genetic and environmental pathomechanisms.

    Objective: To investigate the existence of distinct longitudinal phenotypes of AD and test whether these findings are reproducible in two independent cohorts. Read More

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