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    Japanese guidelines for allergic rhinitis 2017.
    Allergol Int 2017 Feb 14. Epub 2017 Feb 14.
    Department of Otorhinolaryngology, Head & Neck Surgery, University of Yamanashi, Yamanashi, Japan.
    Like asthma and atopic dermatitis, allergic rhinitis is an allergic disease, but of the three, it is the only type I allergic disease. Allergic rhinitis includes pollinosis, which is intractable and reduces quality of life (QOL) when it becomes severe. A guideline is needed to understand allergic rhinitis and to use this knowledge to develop a treatment plan. Read More

    Filaggrin loss-of-function mutations, atopic dermatitis and risk of actinic keratosis: results from two cross-sectional studies.
    J Eur Acad Dermatol Venereol 2017 Feb 18. Epub 2017 Feb 18.
    Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, 2900, Hellerup, Denmark.
    Background: Common loss-of-function mutations in filaggrin gene (FLG) represent a strong genetic risk factor for atopic dermatitis (AD). Homozygous mutation carriers typically display ichthyosis vulgaris (IV) and many have concomitant AD. Previously, homozygous, but not heterozygous, filaggrin gene mutations have been associated with squamous cell carcinomas. Read More

    A Spectrophotometric Study of Eryrhrocyte Porphyrins in Patients of Atopic Dermatitis.
    Indian J Dermatol Venereol Leprol 1981 Sep-Oct;47(5):259-261
    A quantitative assay of porphyrins in blood'of thirty patients with atopic dermatitis was done. Rimington's technique for the estimation of porphyrins was employed. Porphyrin levels in thirty cases of atopic dermatitis were compared with levels in ten controls. Read More

    A Spectrophtometic Study of Faecal in Patients of Atopic Dermatitis.
    Indian J Dermatol Venereol Leprol 1981 Jul-Aug;47(4):215-217
    A quantitative assay of porphyrins in stool of thirty-patients with atopic dermatitis was done. Rimingtlon's technique -for the estimation of Porophyrins was employed. Porphyrin levels in the thirty cases were compared with ten normals which constituted the control group. Read More

    The Skin as a Route of Allergen Exposure: Part II. Allergens and Role of the Microbiome and Environmental Exposures.
    Curr Allergy Asthma Rep 2017 Jan;17(1)
    Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.
    Purpose Of Review: This second part of the article aims to highlight recent contributions in the literature that enhance our understanding of the cutaneous immune response to allergen.

    Recent Findings: Several properties of allergens facilitate barrier disruption and cutaneous sensitization. There is a strong epidemiologic relationship between the microbiome, both the gut and skin, and atopic dermatitis (AD). Read More

    Identification of an epidermal keratinocyte AMPA glutamate receptor involved in dermatopathies associated with sensory abnormalities.
    Pain Rep 2016 Sep;1(3)
    Department of Anesthesiology, Washington University School of Medicine, Washington University Pain Center, St Louis, MO, USA; Department of Neuroscience, Washington University School of Medicine, MO, USA.
    Introduction: Epidermal keratinocytes are increasingly recognized as active participants in the sensory transduction of itch and pain, processes known to involve primary afferent glutamatergic neurons. However the role of keratinocyte glutamate signaling in sensory functioning is not fully understood. Here, we present the observation of α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid type glutamate receptors (AMPAR) in epidermal keratinocytes. Read More

    Usefulness of Sweat Management for Patients with Adult Atopic Dermatitis, regardless of Sweat Allergy: A Pilot Study.
    Biomed Res Int 2017 22;2017:8746745. Epub 2017 Jan 22.
    Department of Dermatology, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan.
    Background. Sweat is an aggravating factor in atopic dermatitis (AD), regardless of age. Sweat allergy may be involved in AD aggravated by sweating. Read More

    Hyperforin/HP-β-Cyclodextrin Enhances Mechanosensitive Ca(2+) Signaling in HaCaT Keratinocytes and in Atopic Skin Ex Vivo Which Accelerates Wound Healing.
    Biomed Res Int 2017 22;2017:8701801. Epub 2017 Jan 22.
    Mechanobiology Laboratory, Nagoya University Graduate School of Medicine, 65 Tsurumai, Nagoya 466-8550, Japan.
    Cutaneous wound healing is accelerated by mechanical stretching, and treatment with hyperforin, a major component of a traditional herbal medicine and a known TRPC6 activator, further enhances the acceleration. We recently revealed that this was due to the enhancement of ATP-Ca(2+) signaling in keratinocytes by hyperforin treatment. However, the low aqueous solubility and easy photodegradation impede the topical application of hyperforin for therapeutic purposes. Read More

    Non-topical management of recalcitrant paediatric atopic dermatitis.
    Arch Dis Child 2017 Feb 16. Epub 2017 Feb 16.
    Dermatology service, KK Women's and Children's Hospital, Singapore.
    Atopic dermatitis (AD) is a common chronic, pruritic skin disease in children. As the incidence of AD increases, especially in high-income countries, paediatricians may see an increasing number of recalcitrant AD cases in their practice. Although these cases are principally managed by paediatric dermatologists, it is important for paediatricians to be aware of the use and side effects of non-topical treatment like phototherapy and systemic agents as well as the evidence for alternative treatment, which caregivers may ask about. Read More

    A clinical trial of intradermal and intramuscular seasonal influenza vaccination in patients with atopic dermatitis.
    J Allergy Clin Immunol 2017 Jan 31. Epub 2017 Jan 31.
    University of Colorado Denver, Aurora, Colo.
    Background: Antibody responses to the inactivated seasonal influenza vaccine in patients with atopic dermatitis (AD) have not been carefully characterized.

    Objective: The primary objective of this study was to compare antibody responses to intradermal vaccination in participants with moderate/severe AD with those in nonatopic participants. Secondary objectives were to evaluate the effect of route of administration, Staphylococcus aureus skin colonization, and disease severity on vaccine response. Read More

    Japanese guidelines for atopic dermatitis 2017.
    Allergol Int 2017 Feb 10. Epub 2017 Feb 10.
    Department of Dermatology, Nara Hospital, Kinki University Faculty of Medicine, Nara, Japan.
    Given the importance of appropriate diagnosis and appropriate assessment of cutaneous symptoms in treatment of atopic dermatitis, the basics of treatment in this guideline are composed of (1) investigation and countermeasures of causes and exacerbating factors, (2) correction of skin dysfunctions (skin care), and (3) pharmacotherapy, as three mainstays. These are based on the disease concept that atopic dermatitis is an inflammatory cutaneous disease with eczema by atopic diathesis, multi-factorial in onset and aggravation, and accompanied by skin dysfunctions. These three points are equally important and should be appropriately combined in accordance with the symptoms of each patient. Read More

    Knowledge, attitudes and practices of the medical personnel regarding atopic dermatitis in Yaoundé, Cameroon.
    BMC Dermatol 2017 Feb 16;17(1). Epub 2017 Feb 16.
    Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, P.O. Box: 8314, Yaoundé, Cameroon.
    Background: Atopic dermatitis (AD) is a chronic, relapsing and pruritic inflammatory skin disease whose management remains unclear to most non-dermatologists. This study aimed to assess the knowledge, attitudes and practices (KAP) of the medical staff regarding AD in Yaoundé, Cameroon.

    Methods: This was a cross-sectional study conducted from January to April 2014 in 20 health facilities located in Yaoundé, the capital city of Cameroon. Read More

    Glucosylsphingosine Activates Serotonin Receptor 2a and 2b: Implication of a Novel Itch Signaling Pathway.
    Biomol Ther (Seoul) 2017 Feb 17. Epub 2017 Feb 17.
    College of Pharmacy, Gachon University, Incheon 21936, Republic of Korea.
    Recent reports claimed that glucosylsphingosine (GS) is highly accumulated and specifically evoking itch-scratch responses in the skins of atopic dermatitis (AD) patients. However, it was unclear how GS can trigger itch-scratch responses, since there were no known molecular singling pathways revealed yet. In the present study, it was verified for the first time that GS can activate mouse serotonin receptor 2a (mHtr2a) and 2b (mHtr2b), but not 2c (mHtr2c) that are expressed in HEK293T cells. Read More

    The Role of the Skin Microbiome in Atopic Dermatitis: A Systematic Review.
    Br J Dermatol 2017 Feb 16. Epub 2017 Feb 16.
    National Allergy Research Centre, Herlev & Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
    Background: Dysbiosis is a hallmark of atopic dermatitis. The composition of skin microbiome communities and the causality of dysbiosis in eczema have not been well established.

    Objective: To describe the skin microbiome profile in atopic dermatitis and address if there is a causal relationship between dysbiosis and atopic dermatitis. Read More

    Allergic rhinitis, atopic dermatitis, and asthma are associated with differences in school performance among Korean adolescents.
    PLoS One 2017 16;12(2):e0171394. Epub 2017 Feb 16.
    Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University College of Medicine, Anyang, Korea.
    Several studies have reported negative relations between allergic diseases and school performance but have not simultaneously considered various allergic diseases, including allergic rhinitis, asthma, and atopic dermatitis, and only examined a limited number of participants. The present study investigated the associations of allergic rhinitis, asthma, and atopic dermatitis with school performance in a large, representative Korean adolescent population. A total of 299,695 7th through 12th grade students participated in the Korea Youth Risk Behaviour Web-based Survey (KYRBWS) from 2009 to 2013. Read More

    Osteoporosis in adult patients with atopic dermatitis: A nationwide population-based study.
    PLoS One 2017 16;12(2):e0171667. Epub 2017 Feb 16.
    Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
    The aim of this study was to investigate osteoporosis risk in atopic dermatitis (AD) patients. This study included patients in the Taiwan National Health Insurance Research dataset. The population-based study included all patients aged 20-49 years who had been diagnosed with AD during 1996-2010. Read More

    Quality of Life of Parents of Children with Atopic Dermatitis.
    Acta Derm Venereol 2017 Feb 16. Epub 2017 Feb 16.
    Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland.
    Atopic dermatitis (AD) is the most common chronic dermatitis in children. The influence of AD on quality of life of parents of children with AD was studied using the Family Dermatology Life Quality Index (FDLQI). Fifty children with AD were included in the study (age range 2-24 months) together with their parents. Read More

    Low maternal prenatal 25-hydroxy vitamin D blood levels are associated with childhood atopic dermatitis.
    J Invest Dermatol 2017 Feb 12. Epub 2017 Feb 12.
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, 401 Park Drive, Suite 401, Boston MA 02215.

    Critically appraised topic on adverse food reactions of companion animals (3): prevalence of cutaneous adverse food reactions in dogs and cats.
    BMC Vet Res 2017 Feb 15;13(1):51. Epub 2017 Feb 15.
    Medizinische Kleintierklinik, Centre for Clinical Veterinary Medicine, Ludwig Maximilian University, Veterinärstrasse 13, 80539, Munich, Germany.
    Background: The prevalence of cutaneous adverse food reactions (CAFRs) in dogs and cats is not precisely known. This imprecision is likely due to the various populations that had been studied. Our objectives were to systematically review the literature to determine the prevalence of CAFRs among dogs and cats with pruritus and skin diseases. Read More

    Therapeutic Effects of Fermented Flax Seed Oil on NC/Nga Mice with Atopic Dermatitis-Like Skin Lesions.
    Evid Based Complement Alternat Med 2017 19;2017:5469125. Epub 2017 Jan 19.
    Department of Ophthalmology & Otolaryngology & Dermatology, College of Korean Medicine, Dongguk University, Dongguk-ro 27, Ilsandong-gu, Goyang-si, Gyeonggi-do 10326, Republic of Korea.
    Background. Atopic Dermatitis (AD) is one of the most common chronic inflammatory skin diseases. Objective. Read More

    Nutritional Status of Infants and Children with Eczematous Dermatitis.
    Indian J Dermatol Venereol Leprol 1982 Jan-Feb;48(1):17-22
    This study was undertaken in a series of 70 infants (48 males, 22 females) and children aged 1 month to 5 years: with eczematous dermatitis (scabetic 36, pediculous 7, microbic 9, seborrhoeic 10, atopic 6 and due to irritant applications 2) as the primary disease for which medical advice was sought.. Nutritional failure was detected anthropothetrically in 58 (83%) of them, including 16(23%) with acute malnutrition and 42(60%) with chronic malnutrition. Read More

    Common Skin Conditions in Children: Noninfectious Rashes.
    FP Essent 2017 Feb;453:18-25
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Cutaneous adverse drug reactions are among the most common noninfectious rashes of childhood. Cutaneous adverse drug reactions are classified as morbilliform, urticarial, bullous, pustular, or psoriasiform. Atopic dermatitis is one of the most common inflammatory cutaneous eruptions, and is characterized by pruritus and flexural distribution. Read More

    Common Skin Conditions in Children: Neonatal Skin Lesions.
    FP Essent 2017 Feb;453:11-17
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Skin findings during the initial month of life are ubiquitous. One study estimated that more than 95% of newborns have cutaneous findings, which often are distressing to parents but frequently are benign and self-limited. Among them are milia, cutis marmorata, congenital dermal melanocytosis, and the benign neonatal pustular eruptions (eg, benign cephalic pustulosis, erythema toxicum neonatorum, transient neonatal pustular melanosis). Read More

    Effects of air pollution on the skin: A review.
    Indian J Dermatol Venereol Leprol 2017 Feb 7. Epub 2017 Feb 7.
    Department of Skin and STD, Vardhman Mahavir Medical College, Safdarjung Hospital, New Delhi, India.
    The increase in air pollution over the years has had major effects on the human skin. Various air pollutants such as ultraviolet radiation, polycyclic aromatic hydrocarbons, volatile organic compounds, oxides, particulate matter, ozone and cigarette smoke affect the skin as it is the outermost barrier. Air pollutants damage the skin by inducing oxidative stress. Read More

    IL-1beta induces thymic stromal lymphopoietin and an atopic dermatitis-like phenotype in reconstructed healthy human epidermis.
    J Pathol 2017 Feb 13. Epub 2017 Feb 13.
    In vitro Pharmacology, Department R&D, Pierre Fabre Dermo-Cosmétique, Toulouse, France.
    Atopic dermatitis (AD) is a common skin inflammatory disease characterized by the production of thymic stromal lymphopoietin (TSLP) and a marked TH 2 polarization. Recent studies suggest that IL-1β contributes to the development of AD skin inflammation. Here, we have investigated the impact of IL-1β signalling on the epidermal homeostasis of both healthy subjects and AD patient [with functional filaggrin (FLG) alleles] with particular attention to TSLP production and keratinocyte differentiation. Read More

    Immediate-type allergic and protease-mediated reactions are involved in scratching behavior induced by topical application of Dermatophagoides farinae extract in NC/Nga mice.
    Exp Dermatol 2017 Feb 13. Epub 2017 Feb 13.
    Strategic Research Planning & Management department, Kyoto R&D Center, Maruho Co., Ltd., Kyoto, Japan.
    Atopic dermatitis (AD)-like dermatitis can be induced by repeated topical application of an ointment containing Dermatophagoides farinae body (Dfb) extract in NC/Nga mice. This AD-like murine model also exhibits a biphasic increase in the number of scratching behavior after topical application of Dfb ointment. In this study, we investigated the possible mechanisms underlying the scratching behavior in each phase. Read More

    Friends or Foes? Host defense (antimicrobial) peptides and proteins in human skin diseases.
    Exp Dermatol 2017 Feb 13. Epub 2017 Feb 13.
    Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.
    Host defense peptides/proteins (HDPs), also known as antimicrobial peptides/proteins (AMPs), are key molecules in the cutaneous innate immune system. AMPs/HDPs historically exhibit broad-spectrum killing activity against bacteria, enveloped viruses, fungi and several parasites. Recently, AMPs/HDPs were shown to have important biological functions, including inducing cell proliferation, migration and differentiation; regulating inflammatory responses; controlling the production of various cytokines/chemokines; promoting wound healing; and improving skin barrier function. Read More

    The histopathological differentiation between palmar psoriasis and hand eczema: A retrospective review of 96 cases.
    J Am Acad Dermatol 2017 Feb 9. Epub 2017 Feb 9.
    Department of Dermatology, Hallym University Sacred Heart Hospital, Anyang, Korea.
    Background: The histopathologic differences among palmar psoriasis (PP), hand eczema (HE), and hyperkeratotic hand dermatitis (HHD) have been poorly described.

    Objectives: We sought to distinguish among PP, HE, and HHD on a histopathologic basis.

    Methods: We retrospectively analyzed the histology of hematoxylin-eosin-stained sections obtained from 96 patients diagnosed with PP, HE, or HHD. Read More

    [Safety of subcutaneous immunotherapy with tyrosine-adsorbed house dust mite extracts in patients with allergic disease].
    Rev Alerg Mex 2017 Jan-Mar;64(1):52-65
    Universidad de Antioquia, IPS Universitaria, Servicio Alergología Clínica. Grupo de Alergología Clínica y Experimental. Medellín, Colombia.
    Background: In spite of allergen-specific immunotherapy (SIT) multiple benefits, its use is restricted in some countries owing to concerns about severe adverse reactions.

    Objective: To evaluate systemic adverse reactions in patients with atopic dermatitis, allergic asthma, allergic rhinitis and allergic conjunctivitis who received subcutaneous immunotherapy with tyrosine-adsorbed Dermatophagoides and Glycyphagoides dust mites extracts.

    Methods: Retrospective study of the 2010-2015-period that included 773 patients diagnosed with IgE-mediated diseases, where the safety of allergen-specific immunotherapy was described according to the World Organization of Allergy subcutaneous immunotherapy-induced systemic reactions classification system. Read More

    Donkey's milk allergy.
    Br J Dermatol 2017 Feb 11. Epub 2017 Feb 11.
    Department of Dermatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
    A 25 years-old woman, with a history of personal atopic dermatitis, allergic asthma and hay fever, experienced a facial angioedema 5 minutes after consuming fresh donkey's milk for the first time (Fig. 1). She developed dyspnea and collapsed after a few minutes. Read More

    Treatment Adherence Intervention Studies in Dermatology and Guidance on How to Support Adherence.
    Am J Clin Dermatol 2017 Feb 10. Epub 2017 Feb 10.
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
    Adequate adherence to prescribed treatment regimens can help to break the cycle of treatment failure, disease progression and subsequent treatment escalation. Unfortunately, adherence in the treatment of skin disorders such as acne, atopic dermatitis/eczema and psoriasis is often inadequate. A review of the literature identified a number of studies that tested an intervention to improve adherence in dermatology, including the following: electronic messages and/or reminders; more frequent or 'extra' clinic visits; audio-visual and internet-based interventions; and patient support programmes and/or self-management, educational training programmes. Read More

    Palivizumab Exposure and the Risk of Atopic Dermatitis, Asthma and Allergic Rhinoconjunctivitis: A Cross-National, Population-Based Cohort Study.
    Paediatr Drugs 2017 Feb 10. Epub 2017 Feb 10.
    The Child and Adolescent Clinic 4072, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
    Background: Palivizumab is a humanized monoclonal antibody designed to provide passive immunity against respiratory syncytial virus. It is prescribed to children at high risk for severe infection with respiratory syncytial virus. However, little is known about the risk of the immune-mediated diseases atopic dermatitis, asthma, and allergic rhinoconjunctivitis after palivizumab exposure. Read More

    A novel DLX3-PKC integrated signaling network drives keratinocyte differentiation.
    Cell Death Differ 2017 Feb 10. Epub 2017 Feb 10.
    Laboratory of Skin Biology, NIAMS, NIH, Bethesda, MD 20892, USA.
    Epidermal homeostasis relies on a well-defined transcriptional control of keratinocyte proliferation and differentiation, which is critical to prevent skin diseases such as atopic dermatitis, psoriasis or cancer. We have recently shown that the homeobox transcription factor DLX3 and the tumor suppressor p53 co-regulate cell cycle-related signaling and that this mechanism is functionally involved in cutaneous squamous cell carcinoma development. Here we show that DLX3 expression and its downstream signaling depend on protein kinase C α (PKCα) activity in skin. Read More

    The Skin as a Route of Allergen Exposure: Part I. Immune Components and Mechanisms.
    Curr Allergy Asthma Rep 2017 Jan;17(1)
    Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.
    Purpose Of Review: To highlight recent contributions in the literature that enhance our understanding of the cutaneous immune response to allergen.

    Recent Findings: Defects in skin barrier function in infancy set the stage for the development of atopic dermatitis (AD) and allergy. Both genetic and environmental factors can contribute to damage of the stratum corneum (SC), with activation of specific protease enzymes under high pH conditions playing a key role. Read More

    Mechanisms of the Development of Allergy (MeDALL): Introducing novel concepts in allergy phenotypes.
    J Allergy Clin Immunol 2017 Feb;139(2):388-399
    Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
    Asthma, rhinitis, and eczema are complex diseases with multiple genetic and environmental factors interlinked through IgE-associated and non-IgE-associated mechanisms. Mechanisms of the Development of ALLergy (MeDALL; EU FP7-CP-IP; project no: 261357; 2010-2015) studied the complex links of allergic diseases at the clinical and mechanistic levels by linking epidemiologic, clinical, and mechanistic research, including in vivo and in vitro models. MeDALL integrated 14 European birth cohorts, including 44,010 participants and 160 cohort follow-ups between pregnancy and age 20 years. Read More

    Determining Effects of Superfine Sheep wool in INfantile Eczema (DESSINE): a randomized paediatric cross over study.
    Br J Dermatol 2017 Feb 9. Epub 2017 Feb 9.
    Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, 3052.
    Introduction: Despite limited evidence, woollen clothing has traditionally been considered to be an irritant that should be avoided by individuals with atopic dermatitis (AD). Wool fibres come in a range of diameters, and have beneficial thermodynamic and moisture transport properties. This study examines the effects of superfine merino wool on symptoms in participants with mild-moderate AD. Read More

    Allergies in urban versus countryside settings in Poland as part of the Epidemiology of the Allergic Diseases in Poland (ECAP) study - challenge the early differential diagnosis.
    Postepy Dermatol Alergol 2016 Oct 21;33(5):359-368. Epub 2016 Oct 21.
    Unit of Environmental Hazard Prevention and Allergology, Faculty of Health Science, Medical University of Warsaw, Warsaw, Poland.
    Introduction: The incidence of allergies depends on a number of factors, including adopting an urban "western" lifestyle, genetic predispositions, and different regions of residence.

    Aim: To compare the prevalence of allergic conditions (seasonal allergic rhinitis (SAR) and perennial allergic rhinitis (PAR), bronchial asthma (BA), atopic dermatitis (AD)) in a group of countryside versus urban residents in Poland.

    Material And Methods: The prevalence of allergic conditions in urban versus countryside settings was assessed using the translated and approved questionnaire developed for international ECRHS II and ISAAC studies. Read More

    Development and Clinical Validation of a Novel Photography-based Skin Erythema Evaluation System: A Comparison with the Calculated Consensus of Dermatologists.
    Int J Cosmet Sci 2017 Feb 8. Epub 2017 Feb 8.
    Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul, 110-799, Korea.
    Erythema is the most common presenting sign of skin conditions [1,2]. Erythema reflects the degree of inflammation associated with various diseases, such as atopic dermatitis, psoriasis, and lupus erythematosus; it is also cosmetically troublesome in subjects with flushing, rosacea, and photoaging [3,4]. In addition, there are vascular disorders that present with erythema, such as nevus flammeus, telangiectasia, and post-acne erythema [5]. Read More

    Lysophosphatidic acid-induced itch is mediated by signaling of LPA5 receptor, phospholipase D and TRPA1/TRPV1.
    J Physiol 2017 Feb 8. Epub 2017 Feb 8.
    Division of Cell Signaling, Okazaki Institute for Integrative Bioscience (National Institute for Physiological Sciences), National Institutes of Natural Sciences, Okazaki, 444-8787, Japan.
    Intractable and continuous itch sensations often accompany diseases such as atopic dermatitis, neurogenic lesions, uremia and cholestasis. Lysophosphatidic acid (LPA) is an itch mediator found in cholestatic itch patients and it induces acute itch and pain in the experimental rodent models. However, the molecular mechanism by which LPA activates peripheral sensory neurons remains unknown. Read More

    Effects of Angelicae dahuricae Radix on 2, 4-Dinitrochlorobenzene-Induced Atopic Dermatitis-Like Skin Lesions in mice model.
    BMC Complement Altern Med 2017 Feb 7;17(1):98. Epub 2017 Feb 7.
    Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University, 1 Hoegi, Seoul, 130-701, Korea.
    Background: Atopic dermatitis (AD) is an inflammatory, chronically relapsing, and intensively pruritic skin disease that affect 10-30% of the global population. Angelicae dahuricae Radix (ADR) has been reported to be anti-inflammatory in Korean Medicine. In the present study, we investigated whether ADR suppresses the progression of AD in animal model. Read More

    Interleukin 4 -590C/T (rs2243250) Polymorphism Is Associated With Increased Risk of Atopic Dermatitis: A Meta-analysis of Case-Control Studies.
    Dermatitis 2017 Feb 6. Epub 2017 Feb 6.
    From the *Institute of Dermatology, Guangzhou Medical University; and †Department of Dermatology, Guangzhou Institute of Dermatology, People's Republic of China.
    Background: Interleukin 4 (IL-4) -590C/T polymorphism has been reported to influence atopic dermatitis (AD) susceptibility, but the results are controversial.

    Objective: This study was conducted to investigate the association between IL-4 -590C/T polymorphism and AD susceptibility.

    Methods: The PubMed, Embase, and China National Knowledge Infrastructure databases were searched. Read More

    Janus kinase inhibitors in dermatology: A systematic review.
    J Am Acad Dermatol 2017 Feb 3. Epub 2017 Feb 3.
    Department of Dermatology, Hadassah - Hebrew University Medical Center, Jerusalem, Israel. Electronic address:
    Background: Janus kinase (JAK) inhibitors are emerging as a promising new treatment modality for many inflammatory conditions.

    Objective: Our aim was to systematically review the available data on the use of JAK inhibitors in cutaneous diseases.

    Methods: This is a systematic review of PubMed and ClinicalTrials. Read More

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