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    Allergic profiles of mothers and fathers in the Japan Environment and Children's Study (JECS): a nationwide birth cohort study.
    World Allergy Organ J 2017 7;10(1):24. Epub 2017 Aug 7.
    Medical Support Center for the Japan Environment and Children's Study, National Center for Child Health and Development, Tokyo, Japan.
    Background: The Japan Environment and Children's Study (JECS) is a nationwide, multicenter, prospective birth cohort investigation launched by the Ministry of Environment in Japan. The purpose of the JECS is to evaluate the influence of prenatal and postnatal exposures to environmental factors on the postnatal health of the children. In this study, we evaluated the allergic characteristics of parents within the JECS cohort. Read More

    Isolation of Group 2 Innate Lymphoid Cells from Mouse Lungs.
    Methods Mol Biol 2017 ;1656:253-261
    Department of Microbiology and Immunology, McGill University Research Centre on Complex Traits (MRCCT), McGill University, 3649 Promenade-Sir-William Osler, Bellini Pavilion Room 371, Montreal, QC, Canada, H3G 0B1.
    The recently described group 2 innate lymphoid cells (ILC2) exert critical roles in type 2 immune responses, epithelial repair at mucosal tissues and metabolic homeostasis. ILC2 release large amounts of type 2 cytokines such as interleukin 4 (IL-4), IL-5, and IL-13, driving type 2 immunity such as the defense against helminths. However, if not tightly regulated ILC2 can trigger unwanted type 2 immunopathologies including allergic airway inflammation, airway hyper-responsiveness, and atopic dermatitis. Read More

    The Role of Intereukin-31 in Pathogenesis of Itch and Its Intensity in a Course of Bullous Pemphigoid and Dermatitis Herpetiformis.
    Biomed Res Int 2017 20;2017:5965492. Epub 2017 Jul 20.
    Department of Dermatology and Venereology, Medical University of Lodz, Poland Hallera Square No. 1, 90-647 Lodz, Poland.
    Itch which is one of the major, subjective symptoms in a course of bullous pemphigoid and dermatitis herpetiformis makes those two diseases totally different than other autoimmune blistering diseases. Its pathogenesis is still not fully known. The aim of this research was to assess the role of IL-31 in development of itch as well as to measure its intensity. Read More

    The role of toll-like receptor 3 in chronic contact hypersensitivity induced by repeated elicitation.
    J Dermatol Sci 2017 Aug 4. Epub 2017 Aug 4.
    Departments of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.
    Background: Accumulating evidence suggests that Toll-like receptor (TLR)-3 signaling is involved in non-infectious immune and inflammatory reactions as well as in viral infections. The skin of patients with atopic dermatitis (AD) is often infected with virus and bacteria, leading to the aggravation of atopic symptoms. These findings suggest TLR3 signaling may be involved in the pathogenesis of AD, but the exact role of TLR3 in AD remains to be defined. Read More

    Molecular and cellular discoveries in inflammatory dermatoses.
    J Eur Acad Dermatol Venereol 2017 Sep;31 Suppl 5:3-7
    Department of Immunology, INSERM U932, Institut Curie, Paris, France.
    It was no earlier than 1986 that T helper (Th)1 and Th2 cells were described for the first time, opening the field of lymphocyte diversity and the investigation of the physiopathology of inflammatory diseases such as atopic dermatitis and psoriasis. Since that time, much research has been carried out showing a very complex communication network leading to inflammatory responses. Nowadays, understanding the cellular and molecular components of the inflammatory network and of the different crosstalks not only for groups of diseases but also for the individual patient is mandatory for developing and personalizing treatments. Read More

    Innate lymphoid cells: major players in inflammatory diseases.
    Nat Rev Immunol 2017 Aug 14. Epub 2017 Aug 14.
    Aix Marseille Université, CNRS, INSERM, Centre d'Immunologie de Marseille-Luminy, Marseille, France.
    Recent years have seen a marked increase in our understanding of innate lymphoid cells (ILCs). ILCs can be classified into different groups based on their similarity to T cell subsets in terms of their expression of key transcription factors and cytokine production. Various immunological functions of ILCs have been described, and increasing numbers of studies have implicated these cells in inflammatory disorders. Read More

    When does atopic dermatitis warrant systemic therapy? Recommendations from an expert panel of the International Eczema Council.
    J Am Acad Dermatol 2017 Aug 10. Epub 2017 Aug 10.
    Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois. Electronic address:
    Background: Although most patients with atopic dermatitis (AD) are effectively managed with topical medication, a significant minority require systemic therapy. Guidelines for decision making about advancement to systemic therapy are lacking.

    Objective: To guide those considering use of systemic therapy in AD and provide a framework for evaluation before making this therapeutic decision with the patient. Read More

    Kimchi intake and atopic dermatitis in Korean aged 19-49 years: The Korea National Health and Nutrition Examination Survey 2010-2012.
    Asia Pac J Clin Nutr 2017 ;26(5):914-922
    Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin, Republic of Korea. Email:
    Background And Objectives: Many studies have reported that fermented foods have favorable effects in preventing and managing atopic dermatitis (AD). Although kimchi, a major fermented food, is an important part of the traditional diet in Korea, only a few studies have investigated the relationship between AD and kimchi. This study aimed to examine the association between the risk of AD and kimchi intake among Korean adults aged 19 to 49 years. Read More

    Pseudolaric acid B attenuates atopic dermatitis-like skin lesions by inhibiting interleukin-17-induced inflammation.
    Sci Rep 2017 Aug 11;7(1):7918. Epub 2017 Aug 11.
    Department of Pathogen Biology and Immunology, Logistics University of Chinese People's Armed Police Force, Tianjin, 300309, P.R. China.
    Pseudolaric acid B (PB), isolated from the extract of the root bark of Pseudolarix kaempferi Gordon, has been used as a traditional remedy for the treatment of skin diseases. However, the information of PB on atopic dermatitis (AD) remains largely unknown. In the present study, oral administration with PB improved the severity scores of AD-like skin lesions dose-dependently in NC/Nga mice through reducing serum IgE, pro-inflammatory cytokines, and the infiltration of inflammatory cells. Read More

    Vaccinations in the first year of life and risk of atopic disease - Results from the KiGGS study.
    Vaccine 2017 Aug 8. Epub 2017 Aug 8.
    Robert Koch Institute, Dept. of Epidemiology and Health Monitoring, Berlin, Germany.
    Background: The study focused on the question of whether and - if so - to what direction and extent immunisations in the 1st year may be associated with the risk of being diagnosed with atopic diseases after the 1st year of life.

    Methods: Data from the German Health Interview and Examination Survey for Children and Adolescents (KiGGS, 2003-2006) were analysed. For analyses of potential associations between vaccination status and risk of hay fever, atopic dermatitis or asthma, sample sizes of 15254, 14297, and 15262, respectively, were available. Read More

    Retinal detachment repair and cataract surgery in patients with atopic dermatitis.
    Eye (Lond) 2017 Aug 11. Epub 2017 Aug 11.
    Department of Ophthalmolgy, Royal Victoria Hospital, Belfast, UK.
    PurposeThe aim of this study is to report a case series of ocular complications including retinal detachment (RD) and cataract in atopic dermatitis (AD) and surgical management involving a majority of Caucasian patients.Patients and methodsThis study is an observational case series, originally designed as an audit. It involves detailed discussion of history, clinical features, and surgical management of patients presenting with retinal detachment and cataracts secondary to severe AD. Read More

    Environmental pollution and allergies.
    J Toxicol Pathol 2017 Jul 26;30(3):193-199. Epub 2017 May 26.
    School of Nursing, University of Shizuoka, 52-1 Yada, Suruga, Shizuoka 422-8526, Japan.
    Environmental changes are thought to be the main factor in the rapid increase and worsening of allergic diseases. While there have been significant changes in many environmental factors, including in environments such as residential, health and sanitation, food, and water/soil/atmospheric environments, the root of each of these changes is likely an increase in chemical substances. In fact, various environmental pollutants, such as air pollutants and chemical substances, have been shown to worsen various allergies in experimental studies. Read More

    Symptoms of allergic rhinitis in Parakou, Benin: Prevalence, severity and associated factors.
    Eur Ann Otorhinolaryngol Head Neck Dis 2017 Aug 7. Epub 2017 Aug 7.
    Faculté des sciences de la santé, Université d'Abomey Calavi, Benin.
    Aims: Allergic rhinitis (AR) is an extremely common disease. This study aimed to determine the prevalence and severity of AR symptoms and potential associated factors, in Parakou, a city in Benin.

    Materials And Methods: A cross-sectional study was conducted between April and July 2016, involving inhabitants of the city aged between 6 and 65 years. Read More

    Cortisol Homeostasis in the Epidermis is Influenced by Topical Corticosteroids in Patients with Atopic Dermatitis.
    Indian J Dermatol 2017 Jul-Aug;62(4):440
    Tsurumai Kouen Clinic, Nakaku, Nagoya 460-0012, Japan.
    Background: The skin produces cortisol by itself and regulates its own proliferation and differentiation. There is a possibility that topical corticosteroids (TCSs) influence the cortisol homeostasis in the skin.

    Aims And Objectives: The author described the density and distribution of cortisol and its parties in the epidermis after application of topical steroids immunohistologically. Read More

    Mania Induced by Narrowband Ultraviolet B Phototherapy Treatment: A Case Report and Review of the Literature.
    Photodermatol Photoimmunol Photomed 2017 Aug 9. Epub 2017 Aug 9.
    Department of Dermatology, Wayne State University School of Medicine, Detroit, MI.
    Phototherapy has been used for decades in the treatment of many common dermatologic conditions, such as psoriasis, atopic dermatitis, cutaneous T cell lymphoma, vitiligo, and scleroderma, among others. Prior to the commencement of phototherapy, many factors must be considered. For dermatologists, the most important factors include the determination of a patient's skin phototype, concurrent use of photosensitizing agents, and calculation of minimal erythema dose (MED). Read More

    The Relationship Between Serum TARC, TSLP and POSTN Levels and Childhood Atopic Dermatitis.
    Clin Lab 2017 Jul;63(7):1071-1077
    Background: The aim of the study is to evaluate the relationship between serum periostin (POSTN), thymus and activation-regulated chemokine (TARC), and thymic stromal lymphopoietin (TSLP) levels and disease severity and atopy in children with atopic dermatitis.

    Methods: Sixty children with atopic dermatitis and 31 healthy controls were included in the study. The disease severity was measured by SCORAD scores. Read More

    Role of Microbial Modulation in Management of Atopic Dermatitis in Children.
    Nutrients 2017 Aug 9;9(8). Epub 2017 Aug 9.
    Nutricia Research, 3584 CT Utrecht, The Netherlands.
    The pathophysiology of atopic dermatitis (AD) is multifactorial and is a complex interrelationship between skin barrier, genetic predisposition, immunologic development, skin microbiome, environmental, nutritional, pharmacological, and psychological factors. Several microbial modulations of the intestinal microbiome with pre- and/or probiotics have been used in AD management, with different clinical out-come (both positive, as well as null findings). This review provides an overview of the clinical evidence from trials in children from 2008 to 2017, aiming to evaluate the effect of dietary interventions with pre- and/or pro-biotics for the treatment of AD. Read More

    Physical Activity, Sedentary Habits, Sleep, and Obesity are Associated with Asthma, Allergic Rhinitis, and Atopic Dermatitis in Korean Adolescents.
    Yonsei Med J 2017 Sep;58(5):1040-1046
    Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
    Purpose: Since pathophysiologic evidence has been raised to suggest that obesity could facilitate an allergic reaction, obesity has been known as an independent risk factor for allergic disease such as asthma. However, the relationship between sedentary behavior and lifestyle which could lead to obesity, and those allergic diseases remains unclear.

    Materials And Methods: We analyzed the relations between physical activity, including sitting time for study, sitting time for leisure and sleep time, and obesity, asthma, allergic rhinitis, and atopic dermatitis using the Korea Youth Risk Behavior Web-based Survey, which was conducted in 2013. Read More

    Atopic Dermatitis Studies through In Vitro Models.
    Front Med (Lausanne) 2017 24;4:119. Epub 2017 Jul 24.
    Cell and Tissue Laboratory, URPhyM-NARILIS, University of Namur, Namur, Belgium.
    Atopic dermatitis (AD) is a complex inflammatory skin condition that is not fully understood. Epidermal barrier defects and Th2 immune response dysregulations are thought to play crucial roles in the pathogenesis of the disease. A vicious circle takes place between these alterations, and it can further be complicated by additional genetic and environmental factors. Read More

    Brain Processing of Contagious Itch in Patients with Atopic Dermatitis.
    Front Psychol 2017 25;8:1267. Epub 2017 Jul 25.
    Department of Dermatology and Cutaneous Surgery and Miami Itch Center, Miller School of Medicine, University of Miami, MiamiFL, United States.
    Several studies show that itch and scratching cannot only be induced by pruritogens like histamine or cowhage, but also by the presentation of certain (audio-) visual stimuli like pictures on crawling insects or videos showing other people scratching. This phenomenon is coined "Contagious itch" (CI). Due to the fact that CI is more profound in patients with the chronic itchy skin disease atopic dermatitis (AD), we believe that it is highly relevant to study brain processing of CI in this group. Read More

    An observational study on the effects of aviation turbine fuel and lubricants on the skin of Indian Air Force ground crew in flying stations.
    Med J Armed Forces India 2017 Jul 11;73(3):294-298. Epub 2016 Aug 11.
    Assistant Surgeon, O/o Deputy Director Medical Services (Leprosy), Collectorate, Salem District, Tamil Nadu 636001, India.
    Background: Ground crew of the Air Force routinely handle aviation turbine fuel (ATF) and lubricants and a need was felt to study the adverse effects of these substances on their skin so that remedial measures could be taken to prevent these adverse effects.

    Methods: A multi-centric, cross-sectional, observational study was performed at three Air Force flying stations. 109 ground crew members of the Indian Air Force (IAF) who were in direct contact with ATF and lubricants were screened for dermatological manifestations on exposed areas. Read More

    Utility of Boron in Dermatology.
    J Dermatolog Treat 2017 Aug 9:1-20. Epub 2017 Aug 9.
    a Department of Dermatology , Center for Dermatology Research, Wake Forest School of Medicine , Winston-Salem , North Carolina.
    Introduction: Boron compounds are being investigated as therapies for dermatologic conditions. Several features of boron chemistry make this element an ideal component in dermatologic treatments. We review the published dermatologically-relevant clinical trials and case studies pertaining to boron compounds. Read More

    Prescriptions for atopic dermatitis: oral corticosteroids remain commonplace.
    J Dermatolog Treat 2017 Aug 9:1-10. Epub 2017 Aug 9.
    a Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine , Winston-Salem , North Carolina.
    Introduction: Atopic dermatitis (AD) is a common, chronic inflammatory skin disease characterized by pruritic, often lichenified, patches and plaques.

    Methods: Data were obtained from the Humana database, a large claims-based database encompassing more than 20 million patients under a commercial healthcare insurance plan. Our cohort included 39,526 subjects who saw a dermatologist for a primary ICD-9 diagnosis of atopic dermatitis (691. Read More

    The Trend of Change of Allergic Diseases over the Years: Three Repeated Surveys from 1994 to 2014.
    Int Arch Allergy Immunol 2017 Aug 9;173(3):178-182. Epub 2017 Aug 9.
    Department of Pediatric Allergy and Immunology, Çukurova University Faculty of Medicine, Adana, Turkey.
    Background: Although it is known that there has been an increase in asthma and allergic diseases among school-aged children, results vary between countries. The aim of this study was to examine trends in the prevalence of these diseases in the city of Adana (south Turkey) over the last 20 years based on the results of 3 cross-sectional studies.

    Methods: Three cross-sectional surveys were performed 10 years apart in south Turkey. Read More

    Image-based haptic roughness estimation and rendering for haptic palpation from in vivo skin image.
    Med Biol Eng Comput 2017 Aug 8. Epub 2017 Aug 8.
    Department of Information and Telecommunication Engineering, Incheon National University, 119 Academy-ro, Yeonsu-gu, Incheon, 22012, South Korea.
    Despite the advancement of measuring technologies, there was a need for palpation by hands to be able to better diagnose skin diseases and to learn about the tactile properties of in vivo skin surface. However, directly touching in vivo skin surface can cause secondary infections or damages. Therefore, a technology providing infection- and damage-free skin palpations and precise haptic skin roughness rendering is needed. Read More

    Impetiginized Dyshidrotic Eczema.
    Open Access Maced J Med Sci 2017 Jul 19;5(4):539-540. Epub 2017 Jul 19.
    Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Friedrichstrasse 41, 01067, Dresden, Germany.
    A 16 years old female patient, affected by atopic dermatitis and rhinoconjunctivitis allergica since childhood, requested a dermatologic consultation for lesions which had appeared after 3 months of local treatment with clobethasole propionate. The histological analysis confirmed the diagnosis of dyshidrotic eczema and the microbiological smears demonstrated a significant infection with Staphylococcus aureus. The risk of developing corticosteroids' side-effects depends on the potency of the product, extended period of use and the volume of product applied. Read More

    Use of moisturizers among Danish atopic dermatitis patients- which perceived product characteristics associate with long-term adherence?
    J Dermatolog Treat 2017 Aug 7:1-18. Epub 2017 Aug 7.
    b Department of Dermatology Zealand University Hospital , Sygehusvej 5 , 4000 Roskilde , Denmark.
    Purpose: To identify factors perceived as most important regarding choice and continued use of moisturizers for adult patients with AD.

    Method And Materials: Online survey among members of the Atopic dermatitis society Denmark.

    Results: Among 75 participants, the most commonly tried (89,3%) and preferred (16%) product was Locobase® (Leo Pharma, Denmark). Read More

    Skin diseases of the vulva: eczematous diseases and contact urticaria.
    J Obstet Gynaecol 2017 Aug 7:1-6. Epub 2017 Aug 7.
    a Department of Dermatology , Bispebjerg Hospital , Copenhagen , Denmark.
    Skin diseases in the vulvar area include a variety of disorders many of which have a chronic course with significant morbidity. It is important to be aware of the symptoms, signs and diagnostic tools in order to optimise treatment. Herein, the most common eczematous diseases of the vulvar area, i. Read More

    Conditional knock out of N-WASP in keratinocytes causes skin barrier defects and atopic dermatitis-like inflammation.
    Sci Rep 2017 Aug 4;7(1):7311. Epub 2017 Aug 4.
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551, Republic of Singapore.
    Neural-Wiskott Aldrich Syndrome Protein (N-WASP) is expressed ubiquitously and regulates actin cytoskeleton remodeling. In order to characterize the role of N-WASP in epidermal homeostasis and cutaneous biology, we generated conditional N-WASP knockout mouse using CK14-cre (cytokeratin 14) to ablate expression of N-WASP in keratinocytes. N-WASP(K14KO) (N-WASP (fl/fl) ; CK14-Cre) mice were born following Mendelian genetics suggesting that N-WASP expression in keratinocytes is not essential during embryogenesis. Read More

    Atopic and Contact Dermatitis of the Vulva.
    Obstet Gynecol Clin North Am 2017 Sep;44(3):371-378
    Department of Dermatology, Wake Forest University School of Medicine, 4618 Country Club Road, Winston-Salem, NC 27104, USA. Electronic address:
    Pruritus, or itch, is a common vulvar complaint that is often treated empirically as a yeast infection; however, yeast infections are just one of the many conditions that can cause vulvar itch. Ignoring other conditions can prolong pruritus unnecessarily. Atopic dermatitis, irritant contact dermatitis, and allergic contact dermatitis are extremely common noninfectious causes of vulvar itch that are often underdiagnosed by nondermatologists. Read More

    A pilot study of the effect of pullulan-conjugated Der f 2 allergen-specific immunotherapy on canine atopic dermatitis.
    Vet Dermatol 2017 Aug 4. Epub 2017 Aug 4.
    Laboratory of Molecular Diagnostics and Therapeutics, The United Graduate School of Veterinary Science, Yamaguchi University, 1677-1 Yoshida, Yamaguchi, Yamaguchi, 753-8515, Japan.
    Background: Dermatophagoides farinae is a major and common environmental house dust mite involved in canine atopic dermatitis (CAD). A formulation of recombinant protein Der f 2 is available in Japan for immunotherapy in dogs.

    Hypothesis/objectives: To evaluate the efficacy of a recombinant allergen based on Der f 2-pullulan for the treatment of cAD. Read More

    Assessment of dietary food and nutrient intake and bone density in children with eczema.
    Hong Kong Med J 2017 Aug 4. Epub 2017 Aug 4.
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
    Introduction: Dietary restrictions are common among patients with eczema, and such practice may lead to diminished bone mineral density. This study investigated dietary intake and bone mineral density in Hong Kong Chinese children with eczema.

    Methods: This cross-sectional and observational study was conducted in a university-affiliated teaching hospital in Hong Kong. Read More

    Topical ROR inverse agonists suppress inflammation in mouse models of atopic dermatitis and acute irritant dermatitis.
    J Invest Dermatol 2017 Jul 31. Epub 2017 Jul 31.
    Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, MA, USA. Electronic address:
    The retinoic acid receptor-related orphan receptors RORα and RORγ are critical for the functions of specific subsets of T cells and innate lymphoid cells, which are key drivers of inflammatory disease in barrier tissues. Here, we investigate the anti-inflammatory potential of SR1001, a synthetic RORα/γ inverse agonist, in mouse models of atopic dermatitis and acute irritant dermatitis. Topical treatment with SR1001 reduces epidermal and dermal features of MC903-induced atopic dermatitis-like disease, and suppresses the production of type 2 cytokines and other inflammatory mediators in lesional skin. Read More

    House Dust Mite Sensitization Is Inversely Associated with Plasma 25-Hydroxyvitamin D3 Levels in Patients with Severe Atopic Dermatitis.
    Ann Dermatol 2017 Aug 21;29(4):400-406. Epub 2017 Jun 21.
    Department of Dermatology, Kyungpook National University School of Medicine, Daegu, Korea.
    Background: The relationship between atopic dermatitis (AD) and low vitamin D levels has been studied. Emerging evidence has implicated vitamin D as a critical regulator of immunity, playing a role in both the innate and cell-mediated immune systems. However, the effect of vitamin D on house dust mite (HDM) sensitization in patients with AD has not been established. Read More

    Atopic dermatitis is associated with autoimmune but not with cardiovascular comorbidities in a random sample of the general population in Leipzig, Germany.
    J Eur Acad Dermatol Venereol 2017 Jul 31. Epub 2017 Jul 31.
    Department of Dermatology, Venerology and Allergology, Universität Leipzig.
    Atopic dermatitis (AD) was recently reported to be associated with multiple non-atopic comorbidities [1-4], especially of autoimmune or cardiovascular type. This co-occurrence was related to several immune mechanism of AD being shared with other immune-mediated diseases [2], as well as to chronic inflammation and life style factors [5]. This article is protected by copyright. Read More

    Predictors of Inappropriate Use of Diagnostic Tests and Management of Bronchiolitis.
    Biomed Res Int 2017 3;2017:9730696. Epub 2017 Jul 3.
    Department of Pediatrics, School of Medicine, Universidad Nacional de Colombia, Bogota, Colombia.
    Background: The aim of the present study was to determine predictors of inappropriate use of diagnostic tests and management of bronchiolitis in a population of hospitalized infants.

    Methods: In an analytical cross-sectional study, we determined independent predictors of the inappropriate use of diagnostic tests and management of bronchiolitis in a population of hospitalized infants. We defined a composite outcome score as the main outcome variable. Read More

    Personalized treatment of severe atopic dermatitis in a child: a ten-year follow-up.
    Pediatr Allergy Immunol 2017 Jul 29. Epub 2017 Jul 29.
    Allergy Unit, Department of Pediatrics, Anna Meyer Children's University Hospital, Viale Pieraccini 24, 50139, Florence, Italy.
    A 4-year-old-boy with a history of persistent rhinitis and milk and/or egg induced anaphylaxis was first referred to our Allergy Unit in 2008 because of severe atopic dermatitis (AD) since the age of one month. The physical examination was remarkable due to lichenified plaques, scaly and excoriated patchy papules (Figure 1). Moreover he complained of persistent generalized itchiness, with sleeping difficulties which greatly affected his quality of life. Read More

    sQuantification of free fatty acids in human stratum corneum using tandem mass spectrometry and surrogate analyte approach.
    Biomed Chromatogr 2017 Jul 29. Epub 2017 Jul 29.
    Laboratory for Analytical Chemistry, Department for Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb.
    The free fatty acids (FFAs) are one of the major components of the lipids in the stratum corneum (SC), the uppermost layer of the skin. Relative composition of FFAs has been proposed as a biomarker of the skin barrier status in patients with atopic dermatitis (AD). Here, we developed LC-ESI-MS/MS method for simultaneous quantification of a range of FFAs with long and very-long chain length in the SC collected by an adhesive tape (D-Squame). Read More

    Biphasic influence of Staphylococcus aureus on human epidermal tight junctions.
    Ann N Y Acad Sci 2017 Jul 28. Epub 2017 Jul 28.
    Department of Dermatology and Venerology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
    Bacterial infections (e.g., with Staphylococcus aureus) are serious problems in skin with a compromised barrier, such as in patients with atopic dermatitis. Read More

    The association of isoconazole - diflucortolone in the treatment of paediatric tinea corporis.
    J Dermatolog Treat 2017 Jul 28:1-10. Epub 2017 Jul 28.
    a Department of Pathophysiology and Transplantation , Università degli Studi di Milano, I.R.C.C.S. Foundation, Cà Granda Ospedale Maggiore Policlinico , Milan , Italy.
    Background: Tinea corporis is a common mycotic infection in children. Staphylococcus aureus superinfections may be observed in atopic children with tinea corporis suffering from severe pruritus and consequent scratching.

    Objective: From 2006 to 2011, we observed 288 children with mycologically proven tinea corporis. Read More

    Evaluation of Anti-Inflammatory Activities of Qingre-Qushi Recipe (QRQS) against Atopic Dermatitis: Potential Mechanism of Inhibition of IL-33/ST2 Signal Transduction.
    Evid Based Complement Alternat Med 2017 2;2017:2489842. Epub 2017 Jul 2.
    Department of Dermatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200000, China.
    To evaluate the anti-inflammatory activities of QRQS against AD and the inhibitory molecular mechanisms of IL-33/ST2 signal transduction, BALB/c mice were divided into six groups (normal control, OVA control, low-dose of QRQS, middle-dose of QRQS, high-dose of QRQS, and cetirizine) and epicutaneously exposed to ovalbumin or PBS for 3 weeks and treated with QRQS for 2 weeks. Skin biopsies and blood samples were obtained for histological study, antibody analysis, and RNA isolation. HaCaT cells, stimulated by TNF-α and IFN-γ, were treated with QRQS to evaluate mRNA and protein expression by RT-PCR and ELISA. Read More

    Didox (3,4-dihydroxybenzohydroxamic acid) suppresses IL-33-induced cytokine production in primary mouse mast cells.
    Cell Immunol 2017 Jul 11. Epub 2017 Jul 11.
    Department of Biology, Virginia Commonwealth University, Richmond, VA, 23284, United States. Electronic address:
    While IgE is considered the primary mediator of mast cell activation, IL-33 contributes substantially in asthma, allergic rhinitis, and atopic dermatitis. To develop effective treatments for allergic disease, it is important to understand the role of therapeutic agents on IL-33 activation. We examined the effect of Didox (3,4-dihydroxybenzohydroxamic acid), an antioxidant and ribonucleotide reductase (RNR) inhibitor, on IL-33-mediated mast cell activation. Read More

    Severity assessments used for inclusion criteria and baseline severity evaluation in atopic dermatitis clinical trials: a systematic review.
    J Eur Acad Dermatol Venereol 2017 Jul 27. Epub 2017 Jul 27.
    Department of Dermatology, Preventive Medicine and Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL.
    Background: Numerous inclusion criteria and baseline severity assessments are used in clinical trials of atopic dermatitis (AD), which may limit comparison of results.

    Objective: We sought to characterize the inclusion criteria and baseline severity assessments used in randomized controlled trials (RCT) of AD internationally.

    Methods: We performed a systematic review of RCT with a pharmacological intervention from 2007-2016. Read More

    Results of allergen-specific immunotherapy in atopic dogs with Malassezia hypersensitivity: a retrospective study of 16 cases.
    Vet Dermatol 2017 Jul 26. Epub 2017 Jul 26.
    Djurakuten i Stor-Stockholm AB, Kungstensgatan 58, 113 29, Stockholm, Sweden.
    Background: Hypersensitivity reactions to Malassezia spp have been shown to occur in dogs with atopic dermatitis (AD) and to cause exacerbation of clinical signs. Improvement of clinical signs following use of antifungal medication is seen with both Malassezia overgrowth or Malassezia hypersensitivity (MHS). Subcutaneous immunotherapy (SCIT) is considered a safe and effective treatment for management of canine AD. Read More

    Validation of an Egyptian Arabic Version of Skindex-16 and Quality of Life Measurement in Egyptian Patients with Skin Disease.
    Int J Behav Med 2017 Jul 26. Epub 2017 Jul 26.
    Department of Dermatology and Venereology, Assiut University Hospital, Assiut, 71526, Egypt.
    Purpose: To translate and cross-culturally adapt the Skindex-16, a brief skin-disease-specific QoL questionnaire, into Arabic for Egyptians and to evaluate its measurement properties in Egyptian patients with skin disease.

    Method: Translation and cultural adaption were performed following guidelines for cross-cultural adaption of health-related quality of life measures. Subsequently, Skindex-16 was administered to 500 consecutive dermatological patients and 500 healthy persons for verification of its reliability and validity. Read More

    Monogenic immune disorders and severe atopic disease.
    Nat Genet 2017 Jul;49(8):1162-1163
    Department of Pediatrics, British Columbia Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
    Severe allergic disease is common, and few monogenic causes of atopy have been described. A new study that convincingly links severe atopic dermatitis to heterozygous CARD11 mutations with dominant-interfering activity serves as a timely reminder that clinicians should consider the possibility of an underlying monogenic immune disorder when caring for patients suffering from severe allergic disease. Read More

    Association of UBASH3A gene polymorphism and atopic dermatitis in the Chinese Han population.
    Genes Immun 2017 Jul 27. Epub 2017 Jul 27.
    Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, Hefei, Anhui, China.
    Genome-wide association studies have revealed a large number of genetic-risk loci for many autoimmune diseases. One clear finding emerging from the published genetic studies of autoimmunity is that different autoimmune diseases share susceptibility loci. Recent evidence has demonstrated that UBASH3A gene was associated with multiple autoimmune diseases. Read More

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