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    Inhibitory Effect of Carnosol on Phthalic Anhydride-Induced Atopic Dermatitis via Inhibition of STAT3.
    Biomol Ther (Seoul) 2017 Jun 27. Epub 2017 Jun 27.
    College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju 28160, Republic of Korea.
    Carnosol is a phenolic antioxidant present in rosemary (Rosmarinus officinalis). It is known for anti-inflammatory effects, analgesic activity and anti-cancer effects. However, no study has been dedicated yet to its effect on atopic dermatitis (AD). Read More

    Addressing the immunopathogenesis of atopic dermatitis: advances in topical and systemic treatment.
    Semin Cutan Med Surg 2017 Mar;36(2S):S45-S48
    Henry Ford Health System, Detroit, Michigan, USA.
    Several immunologic mediators-phosphodiesterase (PDE), interleukin (IL), small molecules, and Janus kinase-have been implicated in the pathogenesis of atopic dermatitis, and evidence has shown that blocking these mediators can help modify the disease process. Several new topical medications have been developed that target the enzyme PDE; crisaborole was recently approved by the US Food and Drug Administration (FDA) for the treatment of atopic dermatitis, and phase II studies have been completed on OPA-15406. The phase III clinical trial results of the systemic medication dupilumab, an inhibitor of the IL-4 receptor α subunit (which inhibits both IL-4 and IL-13 signaling), are currently being reviewed by the FDA. Read More

    Nonpharmacologic strategies and topical agents for treating atopic dermatitis: an update.
    Semin Cutan Med Surg 2017 Mar;36(2S):S42-S44
    Rady Children's Hospital, University of California, San Diego School of Medicine, San Diego, California, USA.
    The signs and symptoms of atopic dermatitis can be safely and effectively controlled in most patients; in many cases, the disease can be improved to the point that signs and symptoms are absent or minimal. In addition, flares can be effectively controlled and, in some cases, prevented. New topical medications, improved strategies for the use of topical corticosteroids and topical calcineurin inhibitors, and judicious use of nonpharmacologic regimens-including bathing, bleach baths, and early use of emollients-have led to better disease management and improved quality of life for patients and their families. Read More

    Atopic dermatitis progression: evaluating intervention strategies.
    Semin Cutan Med Surg 2017 Mar;36(2S):S39-S41
    Rady Children's Hospital, University of California, San Diego School of Medicine, San Diego, California, USA.
    Several risk factors have been identified that appear to be consistently and strongly associated with the development of atopic dermatitis (AD): a family history of atopy, an inherited genetic predisposition, and active and passive exposure to tobacco smoke. Recent studies also have demonstrated that a simple intervention from birth-the daily application of an emollient moisturizer-seems to protect susceptible infants from the development of AD. Read More

    Practical strategies for the diagnosis and assessment of atopic dermatitis.
    Semin Cutan Med Surg 2017 Mar;36(2S):S36-S38
    Henry Ford Health System, Detroit, Michigan, USA.
    Atopic dermatitis (AD) has a significant, lifelong clinical impact on affected individuals and has profound effects on quality of life both for patients and their families. The diagnosis usually can be reliably established on the basis of the history and physical examination. In patients with skin of color, blanching of the skin may be helpful to detect erythema, lichenification, follicular accentuation, and hypopigmentation (all of which are more common than in lighter-skinned patients). Read More

    PARP14 limits severity of allergic skin disease.
    Immunology 2017 Jun 27. Epub 2017 Jun 27.
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, 46202.
    Poly-ADP ribose polymerase-14 (PARP14 or ARTD8) was initially identified as a transcriptional co-activator for Stat6, where the presence of IL-4 and activated Stat6 induces the enzymatic activity of PARP14 that promotes Th2 differentiation and allergic airway disease. To further our understanding of PARP14 in allergic disease, we studied the function of PARP14 in allergic inflammation of skin using mice that express constitutively active Stat6 in T cells (Stat6VT) and develop spontaneous inflammation of the skin. We mated Stat6VT mice to Parp14-/- mice and observed that approximately 75% of the Stat6VTxParp14-/- mice develop severe atopic dermatitis (AD)-like lesions, compared to about ~50% of Stat6VT mice, and have increased morbidity compared to Stat6VT mice. Read More

    Allergy and Sexual Behaviours: an Update.
    Clin Rev Allergy Immunol 2017 Jun 26. Epub 2017 Jun 26.
    Department of Internal Medicine, Section of Immunoallergology and Respiratory Diseases, University of Florence, Florence, Italy.
    The exact prevalence of hypersensitivity reactions related to sexual behaviours is not known; however, they heavily impact on the quality of life and of sex life of affected patients. In fact, not only common respiratory and skin allergies, such as asthma, rhinitis, urticaria and atopic dermatitis, but also food and drug allergy have been found to negatively affect the quality of sex life. Allergic diseases impact on the sexual function in both physical and psychological ways, representing one of the main complaints of a considerable proportion of patients. Read More

    Advances in atopic dermatitis and urticaria, 2016.
    J Allergy Clin Immunol 2017 Jun 23. Epub 2017 Jun 23.
    Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Singapore Immunology Network (SIgN) and Institute of Medical Biology (IMB), Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore. Electronic address:
    This review highlights recent key advances in the pathology and therapies of inflammatory skin diseases, focusing on atopic dermatitis (AD) and chronic spontaneous urticaria (CSU). Regarding AD, transcriptomic analysis using human samples revealed different immune profiles between childhood AD and adult AD. Phase III clinical trials of dupilumab, an anti-IL4 receptor alpha antibody, on AD have successfully finished, and dupilumab will appear in clinical practice as the first biologics for AD in 2017. Read More

    Time- and dose-dependent claudin contribution to biological functions: Lessons from claudin-1 in skin.
    Tissue Barriers 2017 Jun 19:e1336194. Epub 2017 Jun 19.
    a Laboratory of Biological Science , Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University , Suita , Osaka , Japan.
    There are many types of biologic compartments in the body. Tight junctions (TJs) function to create a dynamic paracellular barrier to separate these compartments and maintain homeostasis. The TJ component claudin-1 is the major transmembrane protein responsible for forming the paracellular barrier in the epidermis; other claudins in the epidermis include claudin-3, -4, -12, -23 and -25. Read More

    Atopic dermatitis is inversely associated with hepatitis B antigen positivity: a population-based cohort study.
    J Eur Acad Dermatol Venereol 2017 Jun 24. Epub 2017 Jun 24.
    Department of Dermatology, College of Medicine, The Catholic University of Korea.
    Background: No clear association between hepatitis B virus (HBV) infection and atopic dermatitis (AD) has been established. Some studies have reported that subjects with HBV had an increased risk of atopy; other studies reported an inverse association between HBV seropositivity and allergic diseases.

    Objective: We evaluated the association between AD and hepatitis B antigen (HBsAg) positivity using Korean National Health and Nutrition Examination Survey data. Read More

    The Changing Landscape of Alopecia Areata: The Therapeutic Paradigm.
    Adv Ther 2017 Jun 23. Epub 2017 Jun 23.
    Department of Dermatology and the Laboratory for Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
    Alopecia areata (AA), a prevalent inflammatory cause of hair loss, lacks FDA-approved therapeutics for extensive cases, which are associated with very poor rates of spontaneous hair regrowth and major psychological distress. Current treatments for severe cases include broad immune-suppressants, which are associated with significant adverse effects, precluding long-term use, with rapid hair loss following treatment termination. As a result of the extent of the disease in severe cases, topical contact sensitizers and intralesional treatments are of limited use. Read More

    The impact of vitamin D supplementation on serum cathelicidin levels and the clinical course of atopic dermatitis in children.
    Minerva Pediatr 2017 Jun 22. Epub 2017 Jun 22.
    Department of Dermatology, Andreas Sygros Hospital, Athens, Greece.
    Background: Cathelicidin has been correlated with the pathophysiology of atopic dermatitis (AD). An indirect correlation of vitamin D with the course of the disease has already been reported as it directly affects the levels of cathelicidin. The purpose of the present article is to investigate the impact of vitamin D supplementation on the course of AD. Read More

    Relevance of cat and dog sensitization by skin prick testing in childhood eczema and asthma.
    Curr Pediatr Rev 2017 Jun 14. Epub 2017 Jun 14.
    The Chinese University of Hong Kong, 6/F, Clinical Sciences Building, Prince of Wales Hospital, Shatin, Hong Kong SAR. China.
    Background: Household animal dander has been implicated as aeroallergen in childhood atopic diseases. Many parents seek healthcare advice if household pet keeping may be detrimental in atopic eczema (AE) and atopies.

    Aim: We investigated if skin sensitization by cat/dog dander was associated with disease severity and quality of life in children with AE. Read More

    A randomised trial of a barrier lipid replacement strategy for the prevention of atopic dermatitis and allergic sensitisation: The PEBBLES Pilot Study.
    Br J Dermatol 2017 Jun 22. Epub 2017 Jun 22.
    Allergy and Lung Health Unit, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, 3010.
    It is hypothesised that the impaired skin barrier in atopic dermatitis (AD) allows the immune system to be exposed to environmental allergens, resulting in sensitisation and allergic disease[1]. Two small trials recently found that routine use of emollients reduced the incidence of AD during the active treatment period by approximately half [2, 3]. It remains unknown if prophylactic use of emollients can prevent the development of AD beyond the treatment period (as opposed to simply delay its onset) or if this reduction in AD leads to a reduced risk of allergic sensitisation. Read More

    Anti-inflammatory potential of a heat-killed Lactobacillus strain isolated from Kimchi on house dust mite-induced atopic dermatitis in NC/Nga mice.
    J Appl Microbiol 2017 Jun 20. Epub 2017 Jun 20.
    Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Republic of Korea.
    Aims: Atopic dermatitis (AD) is an allergic skin disease driven by the Th2-prone immune response. Therefore, a fundamental approach to restoring the Th1/Th2 balance is needed to treat AD.

    Methods And Results: Eighteen different Lactobacillus strains isolated from Kimchi were screened to identify those that stimulated immune cells to secret Th1-type or Th2-type cytokines. Read More

    The validity of register-data to identify children with atopic dermatitis, asthma or allergic rhinoconjunctivitis.
    Pediatr Allergy Immunol 2017 Jun 20. Epub 2017 Jun 20.
    Department of Epidemiology Research, Statens Serum Institut, Denmark.
    Background: The incidence of atopic dermatitis, wheezing, asthma and allergic rhinoconjunctivitis have been increasing. Register-based studies are essential for research in subpopulations with specific diseases, and facilitate epidemiological studies to identify causes and evaluate interventions. Algorithms have been developed to identify children with atopic dermatitis, asthma or allergic rhinoconjunctivitis using register information on disease-specific dispensed prescribed medication and hospital contacts, but the validity of the algorithms has not been evaluated. Read More

    An association between periostin levels with the severity and chronicity of atopic dermatitis in children.
    Pediatr Allergy Immunol 2017 Jun 20. Epub 2017 Jun 20.
    Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea.
    Background: Serum periostin might be a biomarker of the pathogenesis of T helper 2-type allergic diseases. The aim of this study is to investigate the relationship between serum periostin levels and the severity and chronicity of atopic dermatitis (AD) in children.

    Methods: This population-based study examined 4,076 children from aged 4 to 13 years between June 2015 and July 2015. Read More

    Impact of solar ultraviolet radiation on atopic dermatitis symptoms in young children: A longitudinal study.
    Pediatr Allergy Immunol 2017 Jun 20. Epub 2017 Jun 20.
    the Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
    Background: There are controversial data about the effects of sun exposure on atopic dermatitis (AD). We evaluated the association between solar ultraviolet radiation (UVR) exposure and AD symptoms in children.

    Methods: Eighty two children under 6 years (48 boys and 34 girls) with AD living in Seoul, Korea were enrolled and followed for 12 months between September 2013 and August 2014. Read More

    Identification of allergens by IgE-specific testing improves outcomes in atopic dermatitis.
    Int J Dermatol 2017 Jun 20. Epub 2017 Jun 20.
    University of Hawaii School of Medicine, Department of Medicine, Honolulu, HI, USA.
    Introduction: IgE quantitative assaying of allergens (IgEQAA) has long been implemented by allergists in determining patients' reactivities for allergic rhinitis and asthma, two of the three diagnoses in atopic syndrome. This test operates by measuring the patient's IgE response to different allergens and can identify potential triggers for a patient's symptoms. Despite this, IgEQAA has yet to see the same widespread use in the field of dermatology, specifically in the treatment of patients with atopic dermatitis (AD). Read More

    Patterns and predictors of atopic dermatitis disease control past childhood: An observational cohort study.
    J Allergy Clin Immunol 2017 Jun 16. Epub 2017 Jun 16.
    Department of Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia PA; Department of Dermatology, University of Pennsylvania, Philadelphia PA.
    Individuals experience distinct patterns of atopic dermatitis disease control over time; female sex, lower income, non-white race, atopic history and earlier age of onset were highly predictive of persistently active disease into early adulthood. Read More

    Association study of childhood food allergy with GWAS-discovered loci of atopic dermatitis and eosinophilic esophagitis.
    J Allergy Clin Immunol 2017 Jun 16. Epub 2017 Jun 16.
    Laboratory for Respiratory and Allergic Diseases, Center for Integrative Medical Sciences, Institute of Physical and Chemical Research (RIKEN), Kanagawa, Japan; Research Center for Medical Science, The Jikei University School of Medicine, Tokyo, Japan. Electronic address:
    We found associations between FA and 14 GWAS-identified loci of AD and EoE: C11orf30/LRRC32, TMEM232/SLC25A46, TNFRSF6B/ZGPAT, OVOL1, KIF3A/IL13, GLB1, CCDC80, ZNF365, OR10A3/NLRP10, IL2/IL21, CLEC16A/DEXI, ZNF652, TSLP/WDR36 and STAT6. These findings improve our understanding of the complex heterogeneity of FA. Read More

    Germline hypomorphic CARD11 mutations in severe atopic disease.
    Nat Genet 2017 Jun 19. Epub 2017 Jun 19.
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
    Few monogenic causes for severe manifestations of common allergic diseases have been identified. Through next-generation sequencing on a cohort of patients with severe atopic dermatitis with and without comorbid infections, we found eight individuals, from four families, with novel heterozygous mutations in CARD11, which encodes a scaffolding protein involved in lymphocyte receptor signaling. Disease improved over time in most patients. Read More

    Suppressive effect of an aqueous extract of Diospyros kaki calyx on dust mite extract/2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions.
    Int J Mol Med 2017 Jun 12. Epub 2017 Jun 12.
    CMRI, Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu 700-422, Republic of Korea.
    Atopic dermatitis (AD) is a common chronic inflammatory skin disease, affecting 10-20% of individuals worldwide. Therefore, the discovery of drugs for treating AD is an attractive subject and important to human health. Diospyros kaki and Diospyros kaki (D. Read More

    Relationship between EASI and SCORAD severity assessments for atopic dermatitis.
    J Allergy Clin Immunol 2017 Jun 15. Epub 2017 Jun 15.
    Departments of Dermatology, Preventive Medicine and Medical Social Sciences, Feinberg School of Medicine at Northwestern University, Chicago, IL USA; Northwestern Medicine Multidisciplinary Eczema Center, Chicago, IL USA. Electronic address:
    The present study shows a complex relationship between EASI and SCORAD. The results provide support for inclusion of objective-SCORAD and/or SCORAD in addition to EASI in clinical trials. Read More

    Induction, treatment and prevention of eczema vaccinatum in atopic dermatitis mouse models.
    Vaccine 2017 Jun 20. Epub 2017 Jun 20.
    Department of Infectious Diseases, Israel Institute for Biological Research (IIBR), Ness-Ziona, Israel. Electronic address:
    Eczema vaccinatum is a severe and occasionally lethal complication of smallpox vaccine, characterized by systemic viral dissemination, distant from the initial inoculation site of the vaccine. A major risk factor for eczema vaccinatum is a background of atopic dermatitis, a chronic, common allergic, relapsing disorder, manifested by dry and inflamed skin, itchy rash, Th2 biased immune response and hypersensitivity to various antigens. Unlike the severe manifestations of eczema vaccinatum in humans, current models present only mild symptoms that limits examination of potential therapeutics for eczema vaccinatum. Read More

    Systematic Review of Diagnostic Criteria Used in Atopic Dermatitis Randomized Controlled Trials.
    Am J Clin Dermatol 2017 Jun 17. Epub 2017 Jun 17.
    Department of Dermatology, Preventive Medicine and Medical Social Sciences, Northwestern University Feinberg School of Medicine, 676 N. Saint Clair St, Suite 1600, Chicago, IL, 60611, USA.
    Background: Numerous diagnostic criteria for atopic dermatitis are used in clinical trials, which may limit comparison of results.

    Objective: We sought to determine the most commonly used atopic dermatitis diagnostic criteria in randomized controlled trials internationally.

    Methods: We performed a systematic review of randomized controlled trials with a pharmacological intervention from 2007 to 2016. Read More

    Second generation H1 - antihistamines interaction with food and alcohol-A systematic review.
    Biomed Pharmacother 2017 Jun 13;93:27-39. Epub 2017 Jun 13.
    Department of Rescue Medicine, Faculty of Health and Medical Science, Andrzej Frycz Modrzewski Krakow University, 30-705 Kraków, Poland.
    Histamine is a mediator of many physiological processes. It plays an important role in modulating allergy reactions and immune system responses. H1 receptor is a therapeutic target for drugs applied in allergic diseases such as allergic rhinoconjunctivitis, urticarial, or atopic dermatitis. Read More

    Molecular aspects of allergens in atopic dermatitis.
    Curr Opin Allergy Clin Immunol 2017 Jun 15. Epub 2017 Jun 15.
    aDivision of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria bNRC Institute of Immunology FMBA cDepartment of Clinical Immunology and Allergy, Sechenov First Moscow State Medical University, Moscow, Russia.
    Purpose Of Review: Molecular allergology uses pure, mainly recombinant and structurally defined allergen molecules and allergen-derived epitopes to study mechanisms of IgE-associated allergy, to diagnose, and even predict the development of allergic manifestations and to treat and prevent IgE-associated allergies. Atopic dermatitis, a chronic inflammatory skin disease is almost always associated with IgE sensitization to allergens. However, also non-IgE-mediated pathomechanisms seem to be operative in atopic dermatitis and it is often difficult to identify the disease-causing allergens. Read More

    "Inflammatory skin march" in atopic dermatitis and psoriasis.
    Inflamm Res 2017 Jun 15. Epub 2017 Jun 15.
    Department of Dermatology, St. Marianna University School of Medicine, Kawasaki, Japan.
    Background: Comorbidities of cardiovascular diseases (CVDs), metabolic syndrome and autoimmune diseases with systemic inflammation are recent topics in medicine. Inflammatory skin diseases such as atopic dermatitis and psoriasis are an active source of diverse proinflammatory cytokines and chemokines, which are readily detectable in the circulation and are likely to be involved in developing comorbidities.

    Evidence: Both atopic dermatitis and psoriasis are frequently comorbid with CVD, metabolic syndrome and autoimmune diseases, the consequence of which is called "inflammatory skin march", "psoriatic march" or "march of psoriasis". Read More

    Infant formula containing galacto-and fructo-oligosaccharides and Bifidobacterium breve M-16V supports adequate growth and tolerance in healthy infants in a randomised, controlled, double-blind, prospective, multicentre study.
    J Nutr Sci 2016 28;5:e42. Epub 2016 Oct 28.
    NETSTAP e.V., Bochum, Germany.
    The objective of the present study was to evaluate the growth and tolerance in healthy, term infants consuming a synbiotic formula with daily weight gain as the primary outcome. In a randomised, controlled, double-blind, multicentre, intervention study infants were assigned to an extensively hydrolysed formula containing a specific combination of Bifidobacterium breve M-16V and a prebiotic mixture (short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides in a 9:1 ratio; scGOS/lcFOS; synbiotic group), or the same formula without this synbiotic concept for 13 weeks (control group). Anthropometry, formula intake, tolerance, stool characteristics, blood parameters, faecal microbiota and metabolic faecal profile were assessed. Read More

    Apremilast treatment of atopic dermatitis and other chronic eczematous dermatoses.
    J Am Acad Dermatol 2017 Jul;77(1):177-180
    University of New Mexico, Albuquerque, New Mexico; University of Colorado Anschutz Medical Center, Aurora, Colorado. Electronic address:

    Atopic dermatitis and risk of hypertension, type-2 diabetes, myocardial infarction and stroke in a cross-sectional analysis from the Canadian Partnership for Tomorrow Project.
    Br J Dermatol 2017 Jun 15. Epub 2017 Jun 15.
    Department of Dermatology, Alpert Medical School of Brown University.
    Background: Atopic dermatitis (AD) has been associated with cardiovascular risk factors and diseases, but epidemiologic studies to date have found conflicting results.

    Objectives: We aimed to determine the associations of AD with hypertension, type-2 diabetes (T2D), myocardial infarction (MI) and stroke.

    Methods: We conducted a cross-sectional analysis of baseline data from the Canadian Partnership for Tomorrow Project which includes Canadian residents aged 30-74 living in British Columbia, Alberta, Ontario, Quebec and the Atlantic Provinces. Read More

    Comparison of the Simple Patient-Centric Atopic Dermatitis Scoring System PEST with SCORAD in Young Children Using a Ceramide Dominant Therapeutic Moisturizer.
    Dermatol Ther (Heidelb) 2017 Jun 14. Epub 2017 Jun 14.
    Dermatology Research Group, Department of Infection, Immunity and Cardiovascular Disease, Faculty of Medicine, Dentistry and Health, University of Sheffield Medical School, Beech Hill Road, Sheffield, UK.
    Introduction: Patient eczema severity time (PEST) is a new atopic dermatitis (AD) scoring system based on patients' own perception of their disease. Conventional scales such as SCORing of atopic dermatitis (SCORAD) reflect the clinician's observations during the clinic visit. Instead, the PEST score captures eczema severity, relapse and recovery as experienced by the patient or caregiver on a daily basis, promoting patient engagement, compliance with treatment and improved outcomes. Read More

    IL-17 Receptor A Maintains and Protects the Skin Barrier To Prevent Allergic Skin Inflammation.
    J Immunol 2017 Jun 14. Epub 2017 Jun 14.
    School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland;
    Atopic dermatitis (AD) is a common inflammatory skin disease affecting up to 20% of children and 3% of adults worldwide and is associated with dysregulation of the skin barrier. Although type 2 responses are implicated in AD, emerging evidence indicates a potential role for the IL-17A signaling axis in AD pathogenesis. In this study we show that in the filaggrin mutant mouse model of spontaneous AD, IL-17RA deficiency (Il17ra(-/-) ) resulted in severe exacerbation of skin inflammation. Read More

    Prevalence of atopic disease in patients with eosinophilic esophagitis.
    Int Forum Allergy Rhinol 2017 Jun 14. Epub 2017 Jun 14.
    The Cleveland Clinic, Cleveland, OH.
    Background: The objective of this work was to evaluate prevalence of eosinophilic esophagitis (EoE) in the United States, and analyze prevalence of atopic disease in patients with EoE. The study design was a retrospective administrative database analysis in U.S. Read More

    Non-histaminergic and mechanical itch sensitization in atopic dermatitis.
    Pain 2017 Jun 9. Epub 2017 Jun 9.
    1 Laboratory of Experimental Cutaneous Pain Research, SMI, Faculty of Medicine, Aalborg University, Denmark; 2 Department of Dermato-Allergology, Copenhagen University Hospital, Gentofte, Copenhagen, Denmark; 3 Dermatology Center North, Aalborg, Denmark; 4 Department of Clinical Medicine, Faculty of Medicine, Aalborg University, Denmark; 5 Department of Dermatology and Itch Center, University of Miami Miller School of Medicine, Miami, Florida, USA.
    Chronic or episodic severe itch is recurrent in atopic dermatitis (AD). Non-histaminergic neuronal itch pathways are suggested to dominate in AD itch, contributing to an "itch-scratch-itch cycle" that prolongs and worsens itch, pain, and skin lesions. We hypothesized that non-histaminergic neuronal sensitization contributes to itch in AD. Read More

    Comparing Paternal and Maternal Factors in Childhood Atopic Dermatitis.
    Dermatitis 2017 Jun 13. Epub 2017 Jun 13.
    From the *Drexel University College of Medicine, Philadelphia, PA; †Department of Dermatology, University of California, Davis; ‡Department of Dermatology and Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL; and §Department of Medicine, Dermatology Division, University of Arizona, Tucson.
    Atopic dermatitis (AD) is a common inflammatory skin disease that chronically affects children and adults worldwide. Environmental exposures, heritable factors, immune dysregulation, and skin barrier malfunction all contribute to the multifactorial nature of AD. It is known that maternal and paternal influences are important predictors for the risk of AD in offspring. Read More

    Retinal Detachment Associated With Atopic Dermatitis.
    Ophthalmic Surg Lasers Imaging Retina 2017 Jun;48(6):513-517
    Ocular manifestations related to atopic dermatitis include keratoconus, keratoconjunctivitis, cataract, and retinal detachment. The authors report three cases of retinal detachment associated with atopic dermatitis. Although the pathogenesis is poorly understood, chronic blunt trauma may play a role in the development of retinal detachment. Read More

    Detection of Nocturnal Scratching Movements in Patients with Atopic Dermatitis Using Accelerometers and Recurrent Neural Networks.
    IEEE J Biomed Health Inform 2017 Jun 8. Epub 2017 Jun 8.
    Atopic dermatitis is a chronic inflammatory skin condition affecting both children and adults and is associated with pruritus. A method for objectively quantifying nocturnal scratching events could aid in the development of therapies for atopic dermatitis and other pruritic disorders. High-resolution wrist actigraphy (3-D accelerometer sensors sampled at 20 Hz) is a non-invasive method to record movement. Read More

    Successful Treatment of Chronic Staphylococcus aureus-Related Dermatoses with the Topical Endolysin Staphefekt SA.100: A Report of 3 Cases.
    Case Rep Dermatol 2017 May-Aug;9(2):19-25. Epub 2017 May 22.
    Department of Dermatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands.
    Staphylococcus aureus plays an important role in skin and soft tissue infections and contributes to the pathophysiology of complex skin disorders such as atopic dermatitis. Bacterial resistance against commonly used antibiotics has increased considerably in the last decades demanding alternative treatment approaches. We present 3 cases where patients with chronic and recurrent S. Read More

    Cysteinyl Leukotrienes as Potential Pharmacological Targets for Cerebral Diseases.
    Mediators Inflamm 2017 10;2017:3454212. Epub 2017 May 10.
    Department of Pharmacological and Biomolecular Sciences, University of Milan, Via Giuseppe Balzaretti 9, 20133 Milan, Italy.
    Cysteinyl leukotrienes (CysLTs) are potent lipid mediators widely known for their actions in asthma and in allergic rhinitis. Accumulating data highlights their involvement in a broader range of inflammation-associated diseases such as cancer, atopic dermatitis, rheumatoid arthritis, and cardiovascular diseases. The reported elevated levels of CysLTs in acute and chronic brain lesions, the association between the genetic polymorphisms in the LTs biosynthesis pathways and the risk of cerebral pathological events, and the evidence from animal models link also CysLTs and brain diseases. Read More

    Impact of atopic dermatitis on health-related quality of life and productivity in adults in the United States: An analysis using the National Health and Wellness Survey.
    J Am Acad Dermatol 2017 Jun 9. Epub 2017 Jun 9.
    University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
    Background: Given its public health impact, there is need for broad and representative data on the humanistic burden of atopic dermatitis (AD).

    Objective: To establish the humanistic burden of AD in US adults.

    Methods: Data were from the 2013 US National Health and Wellness Survey; AD self-reports were propensity-matched with non-AD controls and with psoriasis controls. Read More

    [Evaluation of quality of life of children with atopic dermatitis before and after treatment].
    Zhongguo Dang Dai Er Ke Za Zhi 2017 Jun;19(6):682-687
    Department of Dermatology, Shanghai Children's Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.
    Objective: To investigate the quality of life of children with atopic dermatitis (AD) and their families, and to assess the changes in quality of life after treatment.

    Methods: The Infants' Dermatitis Quality of Life Index (IDQOL), Children's Dermatology Life Quality Index (CDLQI), and Dermatitis Family Impact (DFI) questionnaires were used to evaluate quality of life in 109 children with AD and 55 normal children. The Severity Scoring of Atopic Dermatitis (SCORAD) was used to evaluate disease severity. Read More

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