Search Our Scientific Publications & Authors

Dermatol Ther 2021 May 13:e14970. Epub 2021 May 13.

St George Dermatology and Skin Cancer Centre, New South Wales, Australia.

The dysfunctional skin barrier in eczema patients may be attributed to decreased levels of ceramides in the stratum corneum. The aim of this study was to determine whether a two-part system consisting of a ceramide-dominant physiological lipid-based moisturizing cream and cleanser could ameliorate the signs and symptoms of moderate eczema in adults over 28 days compared to placebo. Assessments were conducted at baseline and every 7 days thereafter. Read More

Mol Med Rep 2021 Jul 13;24(1). Epub 2021 May 13.

Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Chungcheongbuk‑do 28116, Republic of Korea.

3,4,5‑Trihydroxycinnamic acid (THCA) exhibits anti‑inflammatory activity in acute or chronic inflammatory disorders, such as acute lung injury and asthma. The present study investigated the anti‑inflammatory activity of THCA in a tumor necrosis factor‑α/interferon‑γ (TI) mixture‑stimulated human keratinocyte cell line. The results of ELISA and reverse transcription‑quantitative PCR revealed that THCA reduced the secretion and mRNA expression levels of interleukin (IL)‑6; IL‑8; thymus and activation‑regulated chemokine; macrophage‑derived chemokine; regulated upon activation, normal T cell expressed and secreted; and monocyte chemoattractant protein‑1 in TI mixture‑stimulated HaCaT cells. Read More

Am J Clin Dermatol 2021 May 12. Epub 2021 May 12.

Incyte Corporation, Wilmington, DE, USA.

Background: Pathogenesis of atopic dermatitis (AD) involves the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway. A cream formulation of ruxolitinib, a potent selective JAK1/JAK2 inhibitor, was developed for topical delivery.

Method: Pharmacokinetic data were obtained from three double-blind, vehicle-controlled studies in patients with AD: a phase II study with ruxolitinib cream 0. Read More

Am J Ophthalmol Case Rep 2021 Jun 28;22:101036. Epub 2021 Feb 28.

Advanced Eye Centre, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012, India.

Purpose: A case of anterior lenticular opacities in a patient of Costello Syndrome is reported.

Observations: Bilateral anterior capsular plaque along with anterior lens opacities (Anterior Segment Optical Coherence Tomography) has been demonstrated in a patient of Costello Syndrome presenting with atopic dermatitis.

Conclusions: All patients with Costello Syndrome require a detailed anterior segment examination and a close follow up, as even minute lenticular opacities cause visual impairment leading to amblyopia and may require an early surgical intervention. Read More

Vet Rec Open 2021 Dec 2;8(1):e6. Epub 2021 May 2.

ILC Therapeutics Ltd. Biocity Scotland Lanarkshire UK.

Background: Allergic pruritic diseases are increasingly common in dogs. This group of conditions hampers life quality as pruritus progressively interferes with normal behaviours. Therefore, new treatment modalities for canine allergic pruritic diseases are necessary. Read More

Int Med Case Rep J 2021 5;14:275-278. Epub 2021 May 5.

Gavin Herbert Eye Institute, Department of Ophthalmology, University of California, Irvine, CA, 92697, USA.

Dupilumab is a monoclonal antibody that is used for the treatment of atopic dermatitis (AD) in adults. However, increasing reports of ocular complications including conjunctivitis and dry eye disease have been documented. In this report, we describe a case of a patient who developed limbal stem cell deficiency (LSCD) after prolonged Dupilumab use. Read More

Mol Cells 2021 May 12. Epub 2021 May 12.

Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Korea.

Cluster of differentiation 1 (CD1) is a family of cell-surface glycoproteins that present lipid antigens to T cells. Humans have five CD1 isoforms. CD1a is distinguished by the small volume of its antigen-binding groove and its stunted A' pocket, its high and exclusive expression on Langerhans cells, and its localization in the early endosomal and recycling intracellular trafficking compartments. Read More

J Cosmet Dermatol 2021 May 12. Epub 2021 May 12.

Department of Dermatology, Zealand University Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.

Dry skin or xerosis is a common ailment occurring both as a separate disease entity and as a symptom of other diseases, e.g. it is a cardinal symptom of atopic dermatitis . Read More

JAMA Dermatol 2021 May 12. Epub 2021 May 12.

Translational Research in Inflammatory Skin Diseases, Institute for Health Services Research in Dermatology and Nursing, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Importance: Baricitinib, an oral selective Janus kinase inhibitor, improved the clinical signs and symptoms of moderate to severe atopic dermatitis in the 16-week, phase 3 monotherapy studies, BREEZE-AD1 and BREEZE-AD2. Long-term efficacy has not yet been examined.

Objective: To evaluate the long-term (68-week) efficacy of baricitinib in adults with moderate to severe atopic dermatitis who were treatment responders or partial responders in BREEZE-AD1 and BREEZE-AD2. Read More

Einstein (Sao Paulo) 2021 10;19:eRC6064. Epub 2021 May 10.

Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.

We report the cases of two adolescent siblings with severe atopic dermatitis, who, despite weighing approximately 40kg, presented a good response to dupilumab with the off-label dose for individuals aged 12 years and weighing 60kg. Both had already used cyclosporine, azathioprine, methotrexate and oral corticosteroids for long periods, plus topical treatments with no adequate disease control. Skin lesions were constant and widespread, with frequent skin infections and very poor quality of life, with numerous physical and psychosocial consequences, such as dropping out of school activities due to severe itching, appearance and bullying. Read More

J Cosmet Dermatol 2021 May 12. Epub 2021 May 12.

Northwestern University Feinberg School of Medicine, Medical Dermatology Associates of Chicago, 363 W. Erie Street, Suite 150, Chicago, IL, 60654, USA.

Background: Moisturizers traditionally function to replenish both the intercellular lipid lamella and natural moisturizing factors, and form a hydrolipid film on the skin surface to decrease transepidermal water loss and improve hydration. As we continue to identify epidermal lipid imbalance in patients with atopic dermatitis, we turn to the use of bioactive ingredients in moisturizers for improving barrier repair and function.

Methods: This review aims to explore the modern use of moisturizers in targeting various components of the skin barrier, dampening immune response, and restoring microbial balance. Read More

J Eur Acad Dermatol Venereol 2021 May 11. Epub 2021 May 11.

Centre of Evidence Based Dermatology, School of Medicine, University of Nottingham, Nottingham, NG7 2NR, UK.

Atopic eczema (herein referred to as "eczema") is a skin disease characterised by remitting and relapsing symptoms. The Harmonising Outcome Measures for Eczema (HOME) initiative was developed to establish a core outcome set (COS) for eczema to be measured for all future eczema trials. The core outcome set for atopic eczema clinical trials includes the domain for patient-reported eczema control, but a review of the validation of available eczema control instruments was lacking. Read More

Ann Allergy Asthma Immunol 2021 May 8. Epub 2021 May 8.

Laboratory of Inflammatory Skin Diseases, Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA. Electronic address:

Background: Atopic dermatitis/AD is a common disease, with particularly high prevalence seen in Africa. It is increasingly recognized that AD patients of different ethnic backgrounds have unique molecular signatures in skin, potentially accounting for treatment response variations. However, the skin profile of AD patients from Africa is unknown, hindering development of new treatments targeted to this patient population. Read More

Arch Dermatol Res 2021 May 10. Epub 2021 May 10.

Department of Dermatology, Wake Forest School of Medicine, Center for Dermatology Research, Medical Center Boulevard, Winston-Salem, NC, 27157-1071, USA.

Atopic dermatitis' (AD) systemic involvement is wide-reaching. The cardiovascular and hematological comorbidities of AD have potential for considerable economic and physical burden; however, data surrounding the association between these comorbidities and AD is controversial. This review discusses the cardiovascular and hematological comorbidities of AD, detailing the conflicting evidence, pathophysiology, and connection to medications. Read More

Clin Dermatol 2021 Jan-Feb;39(1):52-55. Epub 2020 Dec 15.

2nd Department of Dermatology, Aristotle University School of Medicine, Papageorgiou General Hospital, Thessaloniki, Greece.

Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, medical professionals have been overwhelmed by questions beyond the infection itself. In dermatology practice, clinicians have been facing difficulties about the management of chronic immune-mediated skin diseases. Issues arose, such as the grade of immunosuppression or immunomodulation, discontinuation or modification of treatment, and initiation of new treatments. Read More

Allergy Asthma Clin Immunol 2021 May 10;17(1):46. Epub 2021 May 10.

1st Department of Pediatrics, Allergology and Cardiology, Wroclaw Medical University, ul. Chalubinskiego 2a, 50-368, Wroclaw, Poland.

Background: Worldwide, allergy affects more than one billion people, with particularly rising prevalence in industrialised areas. Specifically, young adults appear to be predominantly targeted for an allergy diagnosis. Allergic diseases in pregnancy are mainly pre-existing but could also occur de novo. Read More

Dermatology 2021 May 10:1-6. Epub 2021 May 10.

Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.

Skin biomarkers for disease severity and treatment response in atopic dermatitis (AD) are needed. Biopsies cause scarring and tape stripping represents an alternative minimally invasive method for stratum corneum sampling. In this study, we examined the gene expression of cytokines in skin biopsies and cytokines in stratum corneum tape strips collected from adults with AD. Read More

Ann Allergy Asthma Immunol 2021 May 7. Epub 2021 May 7.

Division of Allergy and Immunology and Center for Pediatric Eosinophilic Disorders, Children's Hospital of Philadelphia; Institute for Immunology and Department of Pediatrics, Perelman School of Medicine, Philadelphia, PA, 19104, USA. Electronic address:

Objective: The classical allergic march model posits that atopy begins in infancy with atopic dermatitis and progresses to asthma and allergic rhinitis in a subset of individuals. The growing prevalence and severity of allergic diseases has prompted renewed interest in refining this model. This review outlines epidemiologic evidence for the existence of allergic march trajectories (distinct paths of atopy development in individuals), reviews the roles that genetics, environment, and disease endotypes play in determining trajectory outcomes, and discusses the clinical utility of the trajectory model. Read More

Ann Allergy Asthma Immunol 2021 May 7. Epub 2021 May 7.

Department of Public Health Sciences, Henry Ford Health System, Detroit, MI, USA.

Background: Childhood sensitization patterns have been previously found to be related to variable risk of early life allergic disease in several birth cohorts.

Objective: To determine whether these risks persist into later childhood.

Methods: In the WHEALS birth cohort, previous latent class analysis based on sensitization to ten allergens, found four early life sensitization patterns (ELSP): "Highly sensitized", "Milk/egg dominated", "Peanut and inhalant(s)", and "Low to no sensitization" at age two years. Read More

Clin Exp Dermatol 2021 May 10. Epub 2021 May 10.

Amsterdam University Medical Centers, location AMC, University of Amsterdam, Department of Dermatology, Amsterdam Public Health, Immunity and Infections, Amsterdam, The Netherlands.

Dupilumab is a relatively new treatment option for patients with moderate-to-severe atopic dermatitis. There is a lack of knowledge about treatment with dupilumab during conception in both males and females, as well as during pregnancy and lactation. We report four patients who expressed a wish to conceive during treatment with dupilumab in daily practice. Read More

Clin Exp Allergy 2021 May 9. Epub 2021 May 9.

Johns Hopkins University School of Medicine, Baltimore, MD, U.S.A.

Background: Food allergy continues to pose problems due to its increased frequency and its increasingly high severity. In this context, alongside the traditional avoidance strategies of allergenic foods and desensitization through the cautious progression of exposure to foods in the context of oral immunotherapy (OIT), alternative strategies have made their way in the last decades. We review the possibilities of intervention in food allergy with the use of biological drugs capable of interfering with the synthesis of IgE, with their mechanisms of action, or with the complex of biological mechanisms that lead to the establishment of a food allergy. Read More

J Allergy Clin Immunol Pract 2021 May 6. Epub 2021 May 6.

Department of Internal Medicine, Seoul National University Hospital, Republic of Korea.

Background: Despite a sharp increase in the global prevalence of allergy over the past decade, the relationship between multiple atopic conditions and atrial fibrillation (AF) has not been fully elucidated.

Objective: To determine whether there is an association between atopic diseases and AF and to examine the effect of multiple atopic diseases on the incidence of AF.

Methods: This retrospective population-based study used the database from the 2009 National Health Insurance Services-Health Screening Cohort in Korea. Read More

J Allergy Clin Immunol 2021 May;147(5):1531-1547

Department of Immunology, Mayo Clinic, Rochester, Minn; Division of Allergy, Asthma, and Immunology and Department of Medicine, Mayo Clinic, Scottsdale, Ariz. Electronic address:

In the 12 years since the discovery of innate lymphoid cells (ILCs), our knowledge of their immunobiology has expanded rapidly. Group 2 ILCs (ILC2s) respond rapidly to allergen exposure and environmental insults in mucosal organs, producing type 2 cytokines. Early studies showed that epithelium-derived cytokines activate ILC2s, resulting in eosinophilia, mucus hypersecretion, and remodeling of mucosal tissues. Read More

BMC Gastroenterol 2021 May 8;21(1):207. Epub 2021 May 8.

Department of Gastroenterology and Neurology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita City, Akita, 0108543, Japan.

Background: Various molecular-targeted therapeutic agents that inhibit cytokines and immune checkpoints are used in clinical practice. Some of these biologics that control immunity, such as anti-interleukin-17, anti-programmed cell death protein-1, and anti-cytotoxic T-lymphocyte-associated protein antibodies, affect intestinal immune homeostasis and cause intestinal inflammation. Development of enteritis due to dupilumab (an anti-IL-4Ralpha monoclonal antibody) therapy is not yet reported in the literature. Read More

Georgian Med News 2021 Mar(312):78-82

1V. Karazin Kharkiv National University, School of Medicine; 2SI "Institute of Health of Children and Adolescents of the National Academy of Medical Sciences of Ukraine", Kharkiv, Ukraine.

In this study was to investigate the сoexistence of diabetes mellitus type 1 with other chronic pathology in children and adolescents and their impact on the course of diabetes mellitus type 1 (DM1). The 88 children from 3 to 17 years who had DM1 were observed. The study was conducted by survey with the aim of finding risk factors and associated comorbidties with a questionnaire-based, objective-subjective study. Read More

J Allergy Clin Immunol Pract 2021 May 5. Epub 2021 May 5.

Department of Dermatology, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine University of Oslo, Oslo, Norway.

Biochem Genet 2021 May 8. Epub 2021 May 8.

Institute of Biochemistry and Genetics, Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia.

The GSDMB gene encodes gasdermin B from the family of gasdermin domain-containing proteins involved in various cellular processes related to tumor development and progression, such as differentiation, cell cycle control and apoptosis. Previously, we conducted GWAS on asthma in the Volga-Ural region of Russia and found SNPs associated with asthma with genome-wide significance (rs9303277, rs8067378, rs2290400, rs7216389, rs4795405) and located in the chromosomal region 17q12-q21, which contains IKZF3 (IKAROS family zinc finger 3), ZPBP2 (zona pellucida binding protein-like), GSDMB (gasdermin B), ORMDL3 (orosomucoid 1-like 3) and LRRC3C (leucine-rich repeat-containing 3C) genes. In the present study, we investigated the association of SNPs of the GSDMB gene with the development of various allergic diseases and their combined manifestations in individuals of Russian, Tatar and Bashkir ethnic origin. Read More

Exp Dermatol 2021 May 8. Epub 2021 May 8.

Department of Dermatology, The Third Xiangya Hospital, Central South University, No. 138, Tongzipo Road, Yuelu District, Changsha, Hunan, China, 410013.

Atopic dermatitis (AD) is a chronic inflammatory skin disease involving skin barrier dysfunction and immune imbalance. However, the mechanism of AD is not clear completely, may be related to heredity and environment. Neuropeptides are a class of peptides secreted by nerve endings, they may play roles in promoting vasodilation, plasma extravasation, chemotaxis of inflammatory cells, and mediating pruritus. Read More

J Dermatol 2021 May 7. Epub 2021 May 7.

Department of Dermatology and Venereology, Peking University First Hospital, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, National Clinical Research Center for Skin and Immune Diseases, Beijing, China.

Atopic dermatitis is a chronic relapsing, inflammatory skin disorder associated with skin barrier dysfunction, the prevalence of which has increased dramatically in developing countries. In this article, we propose a treatment algorithm for patients with mild-to-moderate and severe atopic dermatitis flares in daily clinical practice. An international panel of 15 dermatology and allergy experts from eight countries was formed to develop a practical algorithm for the treatment of patients with atopic dermatitis, with a particular focus on topical therapies. Read More

Syst Rev 2021 May 7;10(1):141. Epub 2021 May 7.

Institute for Health Research and Education, Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrueck, Am Finkenhuegel 7a, 49076, Osnabrueck, Germany.

Background: Eczematous skin diseases, e.g., atopic dermatitis or contact dermatitis, are associated with a high disease burden, a significant impact on quality of life and a higher risk for anxiety and depression. Read More