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    Steroid Withdrawal Effects Following Long-term Topical Corticosteroid Use.
    Dermatitis 2018 Jun 19. Epub 2018 Jun 19.
    From the Royal Randwick Medical Centre, New South Wales, Australia.
    Background: Concerns about topical steroid withdrawal (TSW) are leading some patients to cease long-term topical corticosteroid (TCS) therapy. Diagnostic criteria for this condition do not exist.

    Objective: The aim of this study was to examine the demographics and outcomes in adult patients who believe they are experiencing TSW following discontinuation of chronic TCS overuse. Read More
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    The self-assessed psychological comorbidities of prurigo in European patients: A multi-centre study in 13 countries.
    J Eur Acad Dermatol Venereol 2018 Jun 19. Epub 2018 Jun 19.
    Department of Dermatology, University Hospital, Brest, France.
    Background: Prurigo is defined by the presence of chronic pruritus and multiple localized or generalized pruriginous lesions.

    Objective: The aim of this study was to assess the psychological burden of prurigo in patients of European countries.

    Methods: In this multicentre European study, 3635 general dermatology outpatients and 1359 controls were included. Read More
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    The prevalence and risk factors of atopic dermatitis in 6-8 year-old first graders in Taipei.
    Pediatr Neonatol 2018 Jun 1. Epub 2018 Jun 1.
    Department of Pediatrics, Taipei City Hospital Ren-Ai Branch, Department of Allergy and Immunology, West Garden Hospital, Taipei, Taiwan. Electronic address:
    Background: Despite the advance in the understanding of etiology, pathophysiology and diagnosis of atopic dermatitis (AD), its prevalence has increased annually in Taiwan.

    Purposes: The purpose of this study is to explore the prevalence, and personal and environmental risk factors of AD.

    Methods: A cross-sectional survey was conducted via health centers of elementary schools in Taipei city. Read More
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    Allergic contact reaction to antiseptics in very young children.
    J Eur Acad Dermatol Venereol 2018 Jun 19. Epub 2018 Jun 19.
    Department of Adult and Pediatric Dermatology, Bordeaux University Hospitals, France.
    Background: Contact dermatitis from topical antiseptic use has been reported mostly in adults but rare cases of chlorhexidine contact dermatitis have also been described in young children.

    Objective: To evaluate contact allergic dermatitis to antiseptics in young children.

    Methods: The children mostly referred for a misdiagnose (cellulitis) were patch tested with a selection of the European baseline series, an antiseptics series and the personal topical products used. Read More
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    IL-22 promotes allergic airway inflammation in epicutaneously sensitized mice.
    J Allergy Clin Immunol 2018 Jun 16. Epub 2018 Jun 16.
    Division of Immunology, Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA. Electronic address:
    Background: Serum IL-22 levels are elevated in atopic dermatitis (AD), which commonly precedes asthma in the atopic march. Epicutaneous (EC) sensitization in mice results in Th2-dominated skin inflammation that mimics AD, and sensitizes the airways for antigen challenge-induced allergic inflammation characterized by the presence of both eosinophils and neutrophils. EC sensitization results in elevated serum levels of IL-22. Read More
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    Revisiting atopic dermatitis and cardiovascular disease.
    Br J Dermatol 2018 Jun 19. Epub 2018 Jun 19.
    Unit for Population-Based Dermatology Research, St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust and King's College London, UK.
    In the June 2018 issue of British Journal of Dermatology, we wrote a commentary on the potential association (or lack thereof) between atopic dermatitis (AD) and cardiovascular disease. Our commentary, which was in response to a meta-analysis of observational studies, noted that within the evidence to that point, there did not appear to be a consistent causal link. However, we did maintain some skepticism given the flaws in many of the studies included in that meta-analysis. Read More
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    An open study on the efficacy of a recombinant Der f 2 (Dermatophagoides farinae) immunotherapy in atopic dogs in Hungary and Switzerland.
    Vet Dermatol 2018 Jun 17. Epub 2018 Jun 17.
    Dermatology Unit, Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057, Zurich, Switzerland.
    Background: Previously published studies evaluating a recombinant Der f 2-based immunotherapy have demonstrated efficacy in the treatment of dogs experimentally and naturally sensitized to house dust mites (HDM). Der f 2 sensitization is thought to play a minor role in European atopic dogs sensitized to HDM.

    Objective: The study evaluated the short-term efficacy of a recombinant Der f 2 product in the treatment of naturally sensitized atopic dogs in Switzerland and Hungary. Read More
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    Bleomycin Aggravates Atopic Dermatitis via Lung Inflammation in 2,4-Dinitrochlorobenzene-Induced NC/Nga Mice.
    Front Pharmacol 2018 1;9:578. Epub 2018 Jun 1.
    Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon, South Korea.
    Atopic dermatitis (AD) is a chronic inflammatory skin disease. Bleomycin (BLM) contributes to the induction of pulmonary inflammation and fibrosis in animals. Although skin and lung tissue inflammation is closely related in the pathogenesis of allergic diseases, a proper animal model for investigating the relationship between skin and lung inflammation is lacking. Read More
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    Preparation, characterizations and anti-pollutant activity of 7,3',4'-trihydroxyisoflavone nanoparticles in particulate matter-induced HaCaT keratinocytes.
    Int J Nanomedicine 2018 1;13:3279-3293. Epub 2018 Jun 1.
    Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung.
    Background: 7,3',4'-Trihydroxyisoflavone (734THI), a secondary metabolite derived from daidzein in soybean, possesses several biological activities, including antioxidant, skin whitening and anti-atopic dermatitis properties, but the poor aqueous solubility of 734THI has limited its application in medicine and cosmetic industry.

    Methods: The aim of the present study was to improve the physicochemical properties of 734THI using planetary ball mill preparation under a solvent-free process to improve its solubility and anti-pollutant activity.

    Results: 734THI nanoparticle powder (734THIN) was successfully prepared by the planetary ball mill technique using polyvinylpyrrolidone K30 as the excipient. Read More
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    Approaches to target IgE antibodies in allergic diseases.
    Pharmacol Ther 2018 Jun 15. Epub 2018 Jun 15.
    Institut Pasteur, Department of Immunology, Unit of Antibodies in Therapy and Pathology, Paris, France; INSERM, U1222, Paris, France. Electronic address:
    IgE is the antibody isotype found at the lowest concentration in the circulation. However IgE can undeniably play an important role in mediating allergic reactions; best exemplified by the clinical benefits of anti-IgE monoclonal antibody (omalizumab) therapy for some allergic diseases. This review will describe our current understanding of the interactions between IgE and its main receptors FcεRI and CD23 (FcεRII). Read More
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    Traffic-related air pollution and eczema in the elderly: Findings from the SALIA cohort.
    Int J Hyg Environ Health 2018 Jun 13. Epub 2018 Jun 13.
    IUF-Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany. Electronic address:
    Childhood eczema results from an interplay of genetic and environmental factors including Traffic-Related Air Pollution (TRAP). In contrast, little is known about eczema in the elderly in general and its association with TRAP in particular. Animal experiments indicate that the arylhydrocarbon receptor (AHR) might link TRAP and eczema. Read More
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    The use of balneotherapy in dermatology.
    Clin Dermatol 2018 May - Jun;36(3):363-368. Epub 2018 Mar 13.
    Department of Dermatology, State University of New York Downstate Medical Center, Brooklyn, NY.
    Balneotherapy is the treatment of disease by bathing in thermal spring water. This therapy has been used for centuries and remains a popular form of treatment for dermatologic and rheumatologic diseases today. Although the favorable climates of balneotherapy thermal centers have known beneficial effects on psoriasis and atopic dermatitis, the thermal spring waters themselves can also potentially decrease skin inflammation. Read More
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    Treatment of Atopic Dermatitis with Tralokinumab, an Anti-IL-13 Monoclonal Antibody.
    J Allergy Clin Immunol 2018 Jun 12. Epub 2018 Jun 12.
    MedImmune, Cambridge, UK.
    Background: Interleukin (IL)-13 has an important role in atopic dermatitis (AD) pathogenesis. Tralokinumab is a fully human monoclonal antibody that potently and specifically neutralizes IL-13.

    Objective: To evaluate the efficacy and safety of tralokinumab in adults with moderate to severe AD. Read More
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    Pediatric Inpatient and Emergency Dermatology Consultations: A 5-Year Retrospective Analysis.
    P R Health Sci J 2018 Jun;37(2):105-109
    Department of Dermatology, University of Puerto Rico Medical Sciences Campus, San Juan, PR.
    Objective: To characterize and analyze the inpatient and emergency pediatric dermatology consults in our academic hospital center.

    Methods: We reviewed 485 consultations that were done by the University of Puerto Rico Department of Dermatology from July 2007 to June 2012. The date, patient age and gender, consulting service, presumptive diagnosis, final diagnosis, and diagnostic procedures performed were documented for each consult. Read More
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    The rs2167270 polymorphism of leptin gene is associated with atopic dermatitis.
    Dermatoendocrinol 2018 26;10(1):e1454191. Epub 2018 Mar 26.
    Department of Clinical Pharmacology, Jordan University of Science and Technology, Irbid, Jordan.
    Atopic dermatitis is a chronic inflammatory skin disease that arises because of complex environmental, immunological, and genetic interactions. Adipokines are bioactive mediators secreted from adipocytes of white adipose tissue and are known to have a role in body metabolism and regulation of immune responses. Leptin is a proinflammatory adipokine that functions mainly to regulate food intake and energy expenditure. Read More
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    Serum 25-hydroxyvitamin D levels in patients with skin diseases including psoriasis, infections, and atopic dermatitis.
    Dermatoendocrinol 2018 22;10(1):e1442159. Epub 2018 Feb 22.
    International Centre for Skin Diseases DermAllegra, Am Markgrafenpark 6, Pommelsbrunn-Hohenstadt, Germany.
    The pathogenetic role of vitamin D as well as its clinical correlation in inflammatory skin diseases is still uncertain. This study aimed to compare serum levels of 25(OH) vitamin D (calcidiol) in outpatients suffering from different skin diseases using the same laboratory method in one study. In routine serum samples of 1,532 patients from the previous 12 months we identified retrospectively 180 (mean age 49. Read More
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    Children with allergic diseases have an increased subsequent risk of migraine upon reaching school age.
    J Investig Med 2018 Jun 14. Epub 2018 Jun 14.
    School of Medicine, China Medical University, Taichung, Taiwan.
    The association between migraine and allergy has remained a subject of debate for more than a century. To systemically investigate the interaction between children with antecedent allergic diseases and their future risks of migraine on reaching school age, we recruited 16,130 children aged 7-18 with migraine diagnosed between 2000 and 2008, and 64,520 matched controls without a history of migraine. The ORs of migraine were calculated for the association with allergic diseases diagnosed before migraine diagnosis. Read More
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    [Meta-analysis of traditional Chinese medicine Jianpi therapy in treatment of atopic dermatitis].
    Zhongguo Zhong Yao Za Zhi 2018 May;43(9):1922-1933
    Shaanxi Provincial Hospital of Traditional Chinese Medicine, Xi'an 710004, China.
    To evaluate the clinical efficacy of traditional Chinese medicine Jianpi therapy in the treatment of atopic dermatitis. CNKI, Wanfang knowledge service platform, VIP journal database, Chinese biomedical literature database (CBM), PubMed, the Cochrane Library and EMbase database from inception to December 2017 were searched for the randomized controlled trials (RCTs) on traditional Chinese medicine Jianpi therapy in the treatment of atopic dermatitis. Literature selection and information extraction was completed and screened by two independent reviewers, and then the Cochrane recommended bias risk assessment method was used to evaluate the bias risk, and Review Manager 5. Read More
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    Omalizumab an effective and safe alternative therapy in severe refractory atopic dermatitis: A case report.
    Medicine (Baltimore) 2018 Jun;97(24):e10897
    Department of Life, Health and Environmental Sciences, University of L'Aquila.
    Rationale: Atopic dermatitis is a frequent, relapsing, chronic inflammatory skin condition with a deep negative impact on quality of life. Three are the major pathological factors driving its complex pathogenesis: the skin barrier disruption, the altered Th2 cell response and itching. Current management of the disease is often unsatisfactory, unable to induce a complete resolution of signs and symptoms or at least a significant clinical improvement with adequate patient satisfaction. Read More
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    CXCL8 and CXCL11 chemokine secretion in dermal fibroblasts is differentially modulated by vanadium pentoxide.
    Mol Med Rep 2018 Jun 1. Epub 2018 Jun 1.
    Department of Clinical and Experimental Medicine, School of Medicine, University of Pisa, I‑56126 Pisa, Italy.
    An increase in skin rashes or atopic dermatitis has been observed in individuals working with vanadium. However, to the best of our knowledge no in vivo or in vitro studies have evaluated the effect of exposure to vanadium in dermal fibroblasts. Cells viability and proliferation were assessed by WST‑1 assay, cells were treated with increasing concentrations of V2O5 (1, 10 and 100 nM). Read More
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    A Perspective on the Interplay of Ultraviolet-Radiation, Skin Microbiome and Skin Resident Memory TCRαβ+ Cells.
    Front Med (Lausanne) 2018 30;5:166. Epub 2018 May 30.
    Research Unit for Photodermatology, Department of Dermatology, Medical University of Graz, Graz, Austria.
    The human skin is known to be inhabited by diverse microbes, including bacteria, fungi, viruses, archaea, and mites. This microbiome exerts a protective role against infections by promoting immune development and inhibiting pathogenic microbes to colonize skin. One of the factors having an intense effect on the skin and its resident microbes is ultraviolet-radiation (UV-R). Read More
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    Atopic dermatitis-like skin lesions are suppressed in fat-1 transgenic mice through the inhibition of inflammasomes.
    Exp Mol Med 2018 Jun 13;50(6):73. Epub 2018 Jun 13.
    Department of Biochemistry, Chonbuk National University Medical School, Jeonju, Jeonbuk, 54896, Republic of Korea.
    Previous clinical trials have addressed the beneficial effects of fish oil supplementation on atopic dermatitis. Recently, we reported that fat-1 mice, which can convert n-6 to n-3 polyunsaturated fatty acids (PUFAs), are protected against allergic airway inflammation because their Th2 immune responses are suppressed. Here, we examined the effects of endogenously synthesized n-3 PUFAs on atopic dermatitis, a representative Th2-dominant allergic inflammatory disease. Read More
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    Hydrogels for Atopic Dermatitis and Wound Management: A Superior Drug Delivery Vehicle.
    Pharmaceutics 2018 Jun 14;10(2). Epub 2018 Jun 14.
    Department of Research and Development, Ego Pharmaceuticals Pty Ltd., 21-31 Malcolm Road, Braeside, VIC 3195, Australia.
    Wound management, in addition to presenting a significant burden to patients and their families, also contributes significantly to a country’s healthcare costs. Treatment strategies are numerous, but in most cases not ideal. Hydrogels, three-dimensional polymeric materials that can withstand a great degree of swelling without losing structural integrity, are drawing great attention for their use as topical wound management solutions in the form of films and as vehicles for drug delivery, due to their unique properties of high water content, biocompatibility, and flexibility. Read More
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    Evaluation of Hypothalamic-Pituitary-Adrenal Axis Suppression following Cutaneous Use of Topical Corticosteroids in Children: A Meta-Analysis.
    Horm Res Paediatr 2018 Jun 13:1-8. Epub 2018 Jun 13.
    Department of Pediatrics, Division of Endocrinology, University of Virginia, Charlottesville, Virginia, USA.
    Background/aims: A meta-analysis was performed to determine the likelihood of hypothalamic-pituitary-adrenal (HPA) axis suppression following short-term cutaneous treatment of atopic dermatitis with topical corticosteroids (TCS) in pediatric patients.

    Methods: All published pediatric clinical trials evaluating TCS use with pre- and post-treatment HPA axis assessment by cosyntropin stimulation testing were included.

    Results: Of 128 eligible trials, 12 were selected for meta-analysis with a total of 522 participants. Read More
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    Impact of chronic urticaria on quality of life and work in Japan: Results of a real-world study.
    J Dermatol 2018 Jun 13. Epub 2018 Jun 13.
    Hiroshima University, Hiroshima, Japan.
    Little attention has been given to the burden of chronic urticaria (CU) in Japan compared with other skin diseases, such as atopic dermatitis (AD) and psoriasis. The primary objective of the RELEASE study was to evaluate the real-life quality-of-life impairment in CU patients in Japan. Data were collected from 1443 urticaria, 1668 AD and 435 psoriatic patients; 552 urticaria patients who presented urticaria symptoms for over 6 weeks were defined as CU. Read More
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    Vitamins A and E during Pregnancy and Allergy Symptoms in an Early Childhood-Lack of Association with Tobacco Smoke Exposure.
    Int J Environ Res Public Health 2018 Jun 12;15(6). Epub 2018 Jun 12.
    Department of Biological and Environmental Monitoring, Nofer Institute of Occupational Medicine, 91-348 Lodz, Poland.
    Epidemiological studies have suggested an association between maternal antioxidant levels during pregnancy and development of allergic diseases in their offspring. The aim of the study was to determine plasma vitamins A and E concentration in the 1st trimester of pregnancy, at delivery and in cord blood and to search for a relationship with allergy in up to 2-year-old children who were prenatally exposed or not exposed to tobacco smoke. The study participants included 252 mother-child pairs from Polish Mother and Child Cohort. Read More
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    The Atopic Dermatitis and Food Allergy: A Paediatric Approach.
    Curr Pediatr Rev 2018 Jun 12. Epub 2018 Jun 12.
    King's College London and Guy's and St. Thomas' Hospitals NHS Foundation Trust. United Kingdom.
    Atopic dermatitis and food allergy are common conditions of childhood that are closely linked. 30% of children with moderate to severe eczema suffer from food allergy and can present with different types of reactions: immediate or IgE-mediated reactions, delayed or non-IgE-mediated eczematous flares, or a combination of the two. A detailed history is very important when approaching such patients. Read More
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    Long-term topical corticosteroid use and risk of skin cancer: a systematic review.
    JBI Database System Rev Implement Rep 2018 Jun;16(6):1387-1397
    The Nottingham Centre for Evidence-Based Healthcare: a Joanna Briggs Institute Centre of Excellence.
    Objective: The objective of this systematic review was to synthesize available research evidence to determine the risk of skin cancer in patients with long-term use of topical corticosteroids (TCS).

    Introduction: Topical corticosteroids are one of the most commonly prescribed medicines in dermatology and the mainstay of the treatment of atopic dermatitis and other skin conditions such as psoriasis. They are often required for months or years to control the disease and ultimately restore patients' quality of life. Read More
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    Evaluation of Antimicrobial Textiles for Atopic Dermatitis.
    J Eur Acad Dermatol Venereol 2018 Jun 12. Epub 2018 Jun 12.
    Dept. of Dermatology and Allergy, Ludwig-Maximilian University, Munich, Germany.
    Background: Functional textiles have been proposed as safe adjunct treatment for atopic dermatitis (AD). Some data has been published regarding their antimicrobial properties and their clinical efficacy.

    Objective: This study examined the physical and functional properties of 11 commercially available functional textiles, including their antimicrobial activity in vitro, as a function of multiple laundering cycles. Read More
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    Possible Roles of Basophils in Chronic Itch.
    Exp Dermatol 2018 Jun 12. Epub 2018 Jun 12.
    Department of Dermatology and Cutaneous Surgery, Miami Itch Center, University of Miami Miller School of Medicine, Miami, FL, USA.
    Basophils are blood granulocytes and normally constitute less than 1% of blood peripheral leukocytes. Basophils share some morphological and functional similarities with mast cells, and basophils were once regarded as redundant and negligible circulating mast cells. However, recent studies reveal the indispensable roles of basophils in various diseases, including allergic and pruritic diseases. Read More
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    Skin Problems Associated with Insulin Pumps and Sensors in Adults with Type 1 Diabetes: A Cross-Sectional Study.
    Diabetes Technol Ther 2018 Jun 12. Epub 2018 Jun 12.
    1 Department of Pediatrics, Copenhagen Diabetes Research Center (CPH-DIRECT), Copenhagen University Hospital , Herlev and Gentofte, Herlev, Denmark .
    Background: In the future, widespread use of closed-loop infusion (artificial pancreas) systems to treat type 1 diabetes (T1D) may significantly improve glycemic control and enhance treatment flexibility. However, the infusion sets and plasters necessary for these treatments can cause dermatological complications that may hamper the spread of the new technology; few studies have investigated these complications in adults. The aim of this study was to describe the dermatological complications associated with continuous subcutaneous insulin infusion (CSII) and continuous glucose monitoring (CGM) in adults. Read More
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    Pharmacokinetics of low-dose methotrexate in healthy beagle dogs.
    J Vet Pharmacol Ther 2018 Jun 12. Epub 2018 Jun 12.
    Interaction Cellule Environnement, Unité Pharmacologie et Toxicologie, VetAgro Sup-Campus Vétérinaire de Lyon, Marcy l'Etoile, France.
    Methotrexate may be an alternative to ciclosporin in the treatment of canine atopic dermatitis (cAD) as suggested by recent data. The aim of the study was to investigate both the tolerance and the pharmacokinetic behavior of methotrexate (MTX) in plasma, following intravenous (i.v. Read More
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    Dupilumab: Short-term effectiveness and security in real clinical practice. A retrospective multicentric study.
    J Eur Acad Dermatol Venereol 2018 Jun 10. Epub 2018 Jun 10.
    Dermatology Unit. Hospital, Universitario Virgen del Rocio, Sevilla.
    Atopic dermatitis (AD) is a chronic, systemic disease that has a multifactorial etiology, where immune system disorders and epidermal barrier dysfunction are added to the influence of genetic and environmental factors. In AD, Th2 lymphocytes secrete several cytokines, where IL-4 / IL-13 play a key role in the proinflammatory loop, decreasing the expression of structural proteins of the epidermis, and leading to the formation of inflammatory and very pruritic lesions. Dupilumab is a fully human monoclonal antibody (mAb) targeted against the α-subunit of interleukins 4 and 13 receptors (IL-4Rα) that blocks the signaling of both IL-4 and IL-13. Read More
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    Cytokine Gene Polymorphisms in Saudi Patients With Atopic Dermatitis: A Case-Control Study.
    Biomark Insights 2018 4;13:1177271918777760. Epub 2018 Jun 4.
    Scientific Research Center, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
    The cause of atopic dermatitis (AD) is multifactorial and a number of genes including cytokines have been involved. We genotyped 315 subjects for polymorphisms in and and genes. Patients had significantly higher frequency of GA genotype of TNF-α (-308 G/A) than healthy controls. Read More
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    Effects of atopic dermatitis and gender on sebum lipid mediator and fatty acid profiles.
    Prostaglandins Leukot Essent Fatty Acids 2018 Jul 17;134:7-16. Epub 2018 May 17.
    Department of Nutrition, University of California-Davis, Davis, CA 95616, USA; West Coast Metabolomics Center, University of California-Davis Genome Center, Davis, CA 95616, USA; Obesity and Metabolism Research Unit, Western Human Nutrition Research Center, Agricultural Research Service, United States Department of Agriculture, Davis, CA 95616, USA. Electronic address:
    Skin disease alters cutaneous lipid mediator metabolism, and if skin secretions contain evidence of these changes, they may constitute useful clinical matrices with low associated subject burden. The influences of skin diseases on sebum lipid mediators are understudied. Here, sebum oxylipins, endocannabinoids, sphingolipids, and fatty acids were quantified from the non-lesional bilateral cheeks of subjects with and without quiescent atopic dermatitis (AD) using LC-MS/MS and GC-MS. Read More
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    Is a specific eyelid patch test series useful? Results of a French prospective study.
    Contact Dermatitis 2018 Jun 8. Epub 2018 Jun 8.
    Department of Dermatology, CHU Montpellier, Montpellier, France.
    Background: Eyelids are frequent sites of contact dermatitis. No prospective study focused on eyelid allergic contact dermatitis (EACD) has yet been published, and this topic has never been studied in French patients.

    Objectives: To prospectively evaluate the usefulness of an eyelid series in French patients patch tested because of EACD, and to describe these patients. Read More
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    Food-Related Contact Dermatitis, Contact Urticaria, and Atopy Patch Test with Food.
    Clin Rev Allergy Immunol 2018 Jun 7. Epub 2018 Jun 7.
    Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Frauenlobstr. 9-11, 80337, Munich, Germany.
    A wide variety of foods may cause or aggravate skin diseases such as contact dermatitis, contact urticaria, or atopic dermatitis (AD), both in occupational and private settings. The mechanism of action underlying allergic disease to food, food additives, and spices may be immunologic and non-immunologic. The classification and understanding of these reactions is a complex field, and knowledge of the possible reaction patterns and appropriate diagnostic test methods is essential. Read More
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    The AAA Risk Factors Scale: A New Model to Screen for the Risk of Asthma, Allergic Rhinitis and Atopic Dermatitis in Children.
    Med Princ Pract 2018 Jun 7. Epub 2018 Jun 7.
    Objective: To create an allergic disease risk factors scale score that would screen for the risk assessment of asthma, allergic rhinitis and atopic dermatitis in children from 3-17 years.

    Methods: This case-control study, conducted between December 2015 and April 2016, enrolled 1274 children. The allergic disease risk factors scale was created by combining environmental, exposure to toxics during pregnancy and breastfeeding and parental history of allergic diseases. Read More
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    Association of Pediatric Atopic Dermatitis and Cataract Development and Surgery.
    JAMA Ophthalmol 2018 Jun 7. Epub 2018 Jun 7.
    Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
    Importance: There is a paucity of data addressing the risk of cataract development in pediatric patients with atopic dermatitis (AD).

    Objective: To investigate the association of AD with subsequent cataract development and cataract surgery in a Korean pediatric population.

    Design, Setting, And Participants: This population-based retrospective longitudinal cohort study used nationally representative data from the Korean National Health Insurance Service database from 2002 to 2013. Read More
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    From Probiotic to Prebiotic Using Thermal Spring Water.
    J Drugs Dermatol 2018 Jun;17(6):657-662
    Background: La Roche-Posay Thermal Spring Water (LRP-TSW) exhibits both probiotic and prebiotic properties enhancing the diversity of the skin microbiota.

    Methods: A review was undertaken to explore the role of LRP-TSW as a topical probiotic and prebiotic therapy in improving the diversity of the skin microbiota and reducing dryness and pruritus in inflammatory skin diseases.

    Results: The concentration of minerals and non-pathogenic microbes in LRP-TSW may explain its therapeutic benefit when used for inflammatory skin diseases. Read More
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    Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part II.
    J Eur Acad Dermatol Venereol 2018 Jun;32(6):850-878
    Christine Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland.
    This guideline was developed as a joint interdisciplinary European project, including physicians from all relevant disciplines as well as patients. It is a consensus-based guideline, taking available evidence from other guidelines, systematic reviews and published studies into account. This second part of the guideline covers antimicrobial therapy, systemic treatment, allergen-specific immunotherapy, complementary medicine, psychosomatic counselling and educational interventions, whereas the first part covers methods, patient perspective, general measures and avoidance strategies, basic emollient treatment and bathing, dietary intervention, topical anti-inflammatory therapy, phototherapy and antipruritic therapy. Read More
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    A systematic literature review of the human skin microbiome as biomarker for dermatological drug development.
    Br J Clin Pharmacol 2018 Jun 7. Epub 2018 Jun 7.
    Centre for Human Drug Research, Leiden, the Netherlands.
    Aims: To explore the potential of the skin microbiome as biomarker in six dermatological conditions i.e. atopic dermatitis (AD), acne vulgaris (AV), psoriasis vulgaris (PV), hidradenitis suppurativa (HS), seborrheic dermatitis/pityriasis capitis (SD/PC) and ulcus cruris (UC). Read More
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    A Case of Left Ventricular Thrombus with Superior Mesenteric Vein Thrombosis Due to Atopic Dermatitis.
    Int Heart J 2018 Jun 6. Epub 2018 Jun 6.
    Division of Cardiology, Shimane University Faculty of Medicine.
    A 55-year-old man was presented to the emergency room because of abdominal pain for 4 days. He had a history of atopic dermatitis. Left ventricular (LV) asynergy and thrombus was detected on echocardiography, and superior mesenteric vein thrombosis was detected by computed tomography. Read More
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