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Food Chem 2021 Apr 27;359:129965. Epub 2021 Apr 27.

Faculty of Food Science & Technology, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran. Electronic address:

Spray-drying is known as a common and economical technique for the encapsulation of various nutrients and bioactive compounds. However, shear and thermal tensions during atomization and dehydration, as well as physicochemical instability during storage, result in a loss of these compounds. As a solution, bioactives are stabilized into different carriers, among which proteins and peptides are of particular importance due to their functional properties, surface activity, and film/shell formability around particles. Read More

Minerva Pediatr (Torino) 2021 May 5. Epub 2021 May 5.

Medical Clinic, Air Force Health Care Center for Special Services Hangzhou, Hangzhou, China -

J Pharm Biomed Anal 2021 Apr 23;201:114087. Epub 2021 Apr 23.

School of Pharmacy, Chengdu University of Traditional Chinese Medicine, No. 1166 Liutai Avenue, Wenjiang District, Chengdu, Sichuan, 611137, China. Electronic address:

Background: The Bushen Huoxue prescription is a traditional Chinese medicine formula treating diabetic retinopathy, which was developed by our research group. Catalpol, puerarin, salvianolic acid B, ginsenoside Rg1, ginsenoside Rb1 and ginsenoside Rd are six of main effective components, which could be partly representative of this prescription. The corona charged aerosol detector (corona CAD) is one kind of universal detectors equipped with the high performance liquid chromatography (HPLC). Read More

Materials (Basel) 2021 Apr 27;14(9). Epub 2021 Apr 27.

State Key Laboratory of Advanced Processing and Recycling of Nonferrous Metals, Lanzhou University of Technology, Langongping 287 Road, Qilihe District, Lanzhou 730050, China.

The high tensile strength and irradiation resistance of oxide dispersion strengthened (ODS) ferritic steels is attributed to the ultrafine and dispersed oxides within the matrix. The high content of oxygen and yttrium is critical for the formation of dense Y-rich oxides. However, only few studies have reported the effect of oxygen content on the microstructure and mechanical properties of ODS steels. Read More

Materials (Basel) 2021 Apr 20;14(8). Epub 2021 Apr 20.

Department of Mechanical Engineering, École de Technologie Supérieure (ÉTS), Montreal, QC H3C 1K3, Canada.

Carbon fiber reinforced polymers (CFRPs) have found diverse applications in the automotive, space engineering, sporting goods, medical and military sectors. CFRP parts require limited machining such as detouring, milling and drilling to produce the shapes used, or for assembly purposes. Problems encountered while machining CFRP include poor tool performance, dust emission, poor part edge quality and delamination. Read More

Pharmaceutics 2021 Apr 24;13(5). Epub 2021 Apr 24.

Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China.

The prospect of inhaled biologics has garnered particular interest given the benefits of the pulmonary route of administration. Pertinent considerations in producing inhalable dry powders containing biological medicines relate to aerosol performance and protein stability. Spray-freeze-drying (SFD) has emerged as an established method to generate microparticles that can potentially be deposited in the lungs. Read More

Biomolecules 2021 Apr 8;11(4). Epub 2021 Apr 8.

Laboratory of Pharmaceutical and Cosmetic R&D, College of Pharmacy, Federal University of Pará, Belém 66075-110, Brazil.

The industrial processing amazon fruits, like tucuma, generates a large amount of coproducts with large nutritional potential. Thus, this work obtained the oily extract of the tucuma almonds coproducts by green extraction using palm oil by the ultrasound method and then microencapsulated by atomization and verification of its antioxidant activity. Thermogravimetric techniques, infrared spectroscopy, scanning electron microscopy, moisture content, water activity were applied to characterize the microparticles. Read More

ACS Appl Mater Interfaces 2021 May 27;13(17):20885-20896. Epub 2021 Apr 27.

National Engineering Research Center for High Efficiency Grinding, Hunan University, Changsha 410082, P. R. China.

A new method was reported for preparing a magnetically responsive superhydrophobic surface by electrostatic air spray deposition (EASD) and magnetic induction. The mixture was fully atomized under the combined action of the electrostatic field and the high-speed airflow field, and a dense array of micropillars was formed. The atomization mechanism of EASD was explored. Read More

Appl Microbiol Biotechnol 2021 May 22;105(9):3485-3494. Epub 2021 Apr 22.

STLO, INRAE, Institut Agro, 35042, Rennes, France.

Propionibacterium freudenreichii is a beneficial food-grade actinobacterium, widely implemented, and thus consumed, in various food products. As the main application, P. freudenreichii is used as a cheese-ripening starter, mostly in hard type cheeses. Read More

ACS Omega 2021 Apr 31;6(14):9813-9827. Epub 2021 Mar 31.

School of Chemical Engineering, Inner Mongolia Key Laboratory of Theoretical and Computational Chemistry Simulation, Inner Mongolia University of Technology, Hohhot 010051, People's Republic of China.

A systematic investigation of the silver-doped germanium clusters AgGe with = 1-13 in the neutral, anionic, and cationic states is performed using the unbiased global search technique combined with a double-density functional scheme. The lowest-energy minima of the clusters are identified based on calculated energies and measured photoelectron spectra (PES). Total atomization energies and thermochemical properties such as electron affinity (EA), ionization potential (IP), binding energy, hardness, and highest occupied molecular orbital-lowest unoccupied molecular orbital (HOMO-LUMO) gap are obtained and compared with those of pure germanium clusters. Read More

Sci Rep 2021 Apr 15;11(1):8234. Epub 2021 Apr 15.

Medical Ultrasonics Laboratory (MEDUSA), Department of Neuroscience and Biomedical Engineering, Aalto University, 02150, Espoo, Finland.

Despite the ubiquitous use over the past 150 years, the functions of the current medical needle are facilitated only by mechanical shear and cutting by the needle tip, i.e. the lancet. Read More

J Aerosol Med Pulm Drug Deliv 2021 Apr 13. Epub 2021 Apr 13.

Department of Otorhinolaryngology, Faculty of Medicine and Dentistry, Medical University of Warsaw, Warsaw, Poland.

Chronic rhinosinusitis (CRS) is a disease that can significantly reduce patients' quality of life (QoL). Intranasal steroid therapy is the most commonly used treatment for CRS. There are many evaluation tools dedicated to assessing CRS patients' QoL, but none of them evaluates QoL during local steroid therapy. Read More

Drug Des Devel Ther 2021 30;15:1425-1440. Epub 2021 Mar 30.

Department of Chinese Medicine Informatics, Beijing University of Chinese Medicine, Beijing, People's Republic of China.

Purpose: Understanding raw material variability and its impact on product quality are crucial for developing robust pharmaceutical processes. This work aimed to study the effects of spray drying conditions on properties of the spray dried saponin (PNS) powders as well as the subsequent intra-batch dissolution variability of PNS hydrophilic matrix tablets.

Methods: The Plackett-Burman design was applied to screen the critical process parameters (CPPs). Read More

Int J Pharm 2021 Apr 6;602:120547. Epub 2021 Apr 6.

Department of Chemical Engineering, Texas Tech University, Lubbock, TX 79409, United States. Electronic address:

Needle-free jet injections are actuated by a pressure impulse that can be delivered by different mechanisms to generate high-speed jets (V~O10 m/s). During filling and transportation of disposable cartridges and ampoules, bubbles can form, which can be problematic especially for viscous fluids. Here, we report on the effect of location and size of entrapped air pockets in cartridges used in spring-powered jet injections. Read More

J Mol Model 2021 Apr 6;27(5):124. Epub 2021 Apr 6.

Department of Chemistry, Payame Noor University, Tehran, Iran.

DFT calculations are utilized to compare and contrast the substituted aluminum-heterofullerenes, CAl (with n = 1-5) from thermodynamically view point, at density functional theory (DFT). Vibrational frequency analysis confirms that apart from CAl, all studied species are true minima. Considering the optimized geometries shows that all heterofullerenes are isolated-pentagon cage and none collapse to open deformed as segregated structure. Read More

Daru 2021 Apr 4. Epub 2021 Apr 4.

Laboratório de Tecnologia dos Medicamentos, Pharmacy Department, Federal University of Pernambuco, Cidade Universitária, Av. Prof. Arthur de Sá, S/N, CEP: 50740-525, Recife, Pernambuco, Brazil.

Spray-dried extracts are prepared as powders or granules after solvent removal, which can be obtained in the presence or absence of pharmaceutical adjuvants. This work aimed to optimize the process of obtaining dried extracts of Peperomia pellucida L. (HBK) by spray drying. Read More

Biol Trace Elem Res 2021 Apr 1. Epub 2021 Apr 1.

Department of Food Chemistry and Nutrition, Medical College, Jagiellonian University, Medyczna 9, 30-688, Kraków, Poland.

Studies related to the toxicological risk assessment (TRA) of heavy metal impurities (HMIs) in pharmaceuticals are an important issue but there is a lack of refereed literature around the safety of Valeriana officinalis L., radix (Valerian root) as herbal medicinal product (HMP) for the relief of mild nervous tension and sleep disorders according to lead and cadmium impurities. The aim of the study was to estimate the TRA of lead and cadmium in Valeriana officinalis L. Read More

Biomed Pharmacother 2021 Jun 26;138:111475. Epub 2021 Mar 26.

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing City 100700, China. Electronic address:

The purpose of this study was to investigate the antifibrotic effect and anticoagulant ability of salvianolic acid B (SAB) inhalation solution on bleomycin (BLM)-induced idiopathic pulmonary fibrosis (IPF) in rats. We investigated how the osmotic pressure and concentration of SAB in an aerosol exerted effects. We also determined the aerodynamic particle size distribution and the uniformity of the delivery dose; these parameters were found to be suitable for inhalation. Read More

Adv Healthc Mater 2021 Mar 24:e2100266. Epub 2021 Mar 24.

CICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Aveiro, 3810-193, Portugal.

The therapeutic effectiveness and biological relevance of technologies based on adherent cells depend on platforms that enable long-term culture in controlled environments. Liquid-core capsules have been suggested as semipermeable moieties with spatial homogeneity due to the high mobility of all components in their core. The lack of cell-adhesive sites in liquid-core structures often hampers their use as platforms for stem cell-based technologies for long-term survival and cell-directed self-organization. Read More

Inflammopharmacology 2021 Mar 19. Epub 2021 Mar 19.

Immunology Research Center, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran.

Background: Bevacizumab with anti-angiogenesis properties reduces the vascular endothelial growth factor (VEGF) level and has widely been used to treat various diseases such as lung diseases and chronic obstructive pulmonary disease (COPD). This study, therefore, aimed to consider the effects of bevacizumab on VEGF receptor 2 (VEGFR2) and lung inflammation of the ovalbumin-induced rat model of airway hypersensitivity.

Materials And Methods: Twenty-one male Wistar rats were randomly divided into 3 groups (n = 7 in each group): (1) control, (2) ovalbumin (OVA)-sensitized, and (3) OVA-sensitized with bevacizumab (OVA + Bmab). Read More

Vopr Pitan 2021;90(1):102-107. Epub 2021 Jan 20.

Scientific Research Institute of Food-concentrate Industry and Special Food Technology - Branch Federal Research Centre of Nutrition and Biotechnology and Food Safety, 142718, Moscow Region, Leninsky District, village Izmailovo, Russian Federation.

Special diets are used for the treatment and prevention of diseases of the digestive system, taking into account individual food intolerance and possible allergic reactions. The monotony of the diet due to the limited range of recommended foods and dishes negatively affects both the effectiveness of the treatment of gluten intolerance, and the provision of the body with essential and replaceable nutrients. of this study was to determine the selenium content in the flour of gluten-free crops (rice, corn, buckwheat and amaranth), their mixtures, as well as in dishes (pancakes) from a mixture of amaranth and buckwheat flours. Read More

Lab Chip 2021 May;21(9):1779-1787

School of Engineering and Built Environment, Griffith University, Australia. and Queensland Micro and Nanotechnology Centre, Griffith University, Australia.

Electrohydrodynamic atomization has been emerging as a powerful approach for respiratory treatment, including the generation and delivery of micro/nanoparticles as carriers for drugs and antigens. In this work, we present a new conceptual design in which two nozzles facilitate dual electrospray coexisting with ionic wind at chamfered tips by a direct current power source. Experimental results by a prototype have demonstrated the capability of simultaneously generating-and-delivering a stream of charged reduced particles. Read More

Medicine (Baltimore) 2021 Mar;100(11):e24946

The Affiliated Hospital of Shandong University of Traditional Chinese Medicine.

Background: Bronchial Asthma is a chronic, hyperreactive inflammation of the airway that involves a variety of inflammatory cells. Due to the persistence of airway hyperresponsiveness, lung function is progressively damaged, making asthma more stubborn and difficult to heal. In recent years, the prevalence of childhood asthma is still on an increasing trend. Read More

Talanta 2021 May 11;227:122205. Epub 2021 Feb 11.

WARTER Fuels JSC, Chemików 5, 09-411, Płock, Poland.

High-resolution continuum source molecular absorption spectrometry (HR-CS MAS) has been developing fast for fluorine determination, but neither flame nor graphite furnace technique have ever been applied for the analysis of petroleum or its products. Hydrogen fluoride can be applied in technologies of gasoline components production, unfortunately, arising organic fluorides can contaminate final product. The aim of this work was development of fast and simple HR-CS MAS method, with an ordinary air-acetylene flame, for determination of organic F in gasoline and its components. Read More

Adv Colloid Interface Sci 2021 Apr 23;290:102384. Epub 2021 Feb 23.

Faculty of Food Science and Technology, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran. Electronic address:

Hydrophobicity and low aqueous-solubility of different drugs/nutraceuticals remain a persistent challenge for their development and clinical/food applications. A range of nanotechnology strategies have been implemented to address this issue, and amongst which a particular emphasis has been made on those that afford an improved biological performance and tunable release kinetic of bioactives through a one-step process. More recently, the technique of electrospraying (or electrohydrodynamic atomization) has attained notable impulse in virtue of its potential to tune attributes of nano/micro-structured particles (e. Read More

Appl Opt 2021 Feb;60(4):A131-A139

Atomization of low temperature fuel is of great importance in a jet engine combustor, and its visualization and diagnostics are challenging, especially in the presence of shreds and ligaments. A 25 kHz picosecond pulsed digital inline holography system is applied to measure the spray produced by an airblast atomizer with low temperature kerosene. The breakup process of shreds and ligaments of -37 kerosene are visualized and analyzed, revealing the transition of liquid jet disintegrating into droplets under the atomizing air film. Read More

J Chem Theory Comput 2021 Apr 10;17(4):2107-2115. Epub 2021 Mar 10.

Department of Physics, Temple University, Philadelphia, Pennsylvania 19122, United States.

The short-range correlation energy of the random phase approximation (RPA) is too negative and is often corrected by local or nonlocal methods. These beyond-RPA corrections usually lead to a mixed performance for thermodynamics and dissociation properties. RPA+ is an additive correction based on density functional approximations that often gives realistic total energies for atoms or solids. Read More

Sci Adv 2021 03 5;7(10). Epub 2021 Mar 5.

Department of Mechanical Engineering, Indian Institute of Science, Bengaluru, KA 560012, India.

Face masks prevent transmission of infectious respiratory diseases by blocking large droplets and aerosols during exhalation or inhalation. While three-layer masks are generally advised, many commonly available or makeshift masks contain single or double layers. Using carefully designed experiments involving high-speed imaging along with physics-based analysis, we show that high-momentum, large-sized (>250 micrometer) surrogate cough droplets can penetrate single- or double-layer mask material to a significant extent. Read More

Sci Rep 2021 Mar 2;11(1):4998. Epub 2021 Mar 2.

State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang, 550025, China.

Spraying of defoliant can promote centralized defoliation of cotton and advance maturity to facilitate harvesting. Modern pesticide application equipment includes plant protection unmanned aerial vehicles (UAVs), which are used widely for spraying defoliants. However, commonly used defoliant formulations are mainly suspension concentrates and water-dispersible granules, which need to be diluted with water when used. Read More

J Chem Phys 2021 Feb;154(8):084112

Department of Physics, University of Texas at El Paso, El Paso, Texas 79968, USA.

Most widely used density functional approximations suffer from self-interaction error, which can be corrected using the Perdew-Zunger (PZ) self-interaction correction (SIC). We implement the recently proposed size-extensive formulation of PZ-SIC using Fermi-Löwdin Orbitals (FLOs) in real space, which is amenable to systematic convergence and large-scale parallelization. We verify the new formulation within the generalized Slater scheme by computing atomization energies and ionization potentials of selected molecules and comparing to those obtained by existing FLOSIC implementations in Gaussian based codes. Read More