1,841 results match your criteria Atomization And Sprays[Journal]


Direct Observation of Filling Process and Porosity Prediction in High Pressure Die Casting.

Materials (Basel) 2019 Apr 2;12(7). Epub 2019 Apr 2.

Chongqing Changan Automobile Co., Ltd., Chongqing 400023, China.

Although numerical simulation accuracy makes progress rapidly, it is in an insufficient phase because of complicated phenomena of the filling process and difficulty of experimental verification in high pressure die casting (HPDC), especially in thin-wall complex die-castings. Therefore, in this paper, a flow visualization experiment is conducted, and the porosity at different locations is predicted under three different fast shot velocities. The differences in flow pattern between the actual filling process and the numerical simulation are compared. Read More

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https://www.mdpi.com/1996-1944/12/7/1099
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http://dx.doi.org/10.3390/ma12071099DOI Listing
April 2019
1 Read

Supercritical Assisted Electrospray: An Improved Micronization Process.

Polymers (Basel) 2019 Feb 2;11(2). Epub 2019 Feb 2.

Department of Industrial Engineering, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano (SA), Italy.

A new process is proposed that can largely improve classical electrospray (ESPR) atomization, thanks to the addition of supercritical CO₂ (SC-CO₂) to the liquid mixture, in which a polymer is dissolved, forming an expanded liquid. The consequent reduction of surface tension and viscosity allows the production of micrometric or nanometric particles of controlled size and distribution at a production rate up to one hundred times that of the traditional process. The new process was applied to particle generation from a very high molecular weight polyvinylpyrrolidone (PVP) and tested at different polymer percentages by weight and at different pressures. Read More

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http://dx.doi.org/10.3390/polym11020244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419022PMC
February 2019

Performance of the Diffusion Quantum Monte Carlo Method with a Single-Slater-Jastrow Trial Wavefunction Using Natural Orbitals and Density Functional Theory Orbitals on Atomization Energies of the Gaussian-2 Set.

J Phys Chem A 2019 Apr 17. Epub 2019 Apr 17.

Institute of Atomic and Molecular Physics, Key Laboratory of High Energy Density Physics and Technology, Ministry of Education , Sichuan University , Chengdu 610065 , P. R. China.

Performance of the fixed-node diffusion quantum Monte Carlo method (FN-DMC) with a single Slater-Jastrow trial wavefunction using natural orbitals (NOs) from MP2, CCSD, CCSD(T), and CASSCF as well as density functional theory orbitals on atomization energies of the molecules in the Gaussian-2 set is investigated in this work. The effects of spin contamination and pseudopotentials (PPs) are also studied. Our results show that the DMC energy with NOs from MP2 or CCSD(T) is the lowest on average, whereas that from CASSCF is only lower than the DMC energy using Hartree-Fock orbitals. Read More

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http://dx.doi.org/10.1021/acs.jpca.9b01933DOI Listing

Scale-up of pharmaceutical spray drying using scale-up rules: A review.

Int J Pharm 2019 May 22;562:271-292. Epub 2019 Mar 22.

Chemical and Materials Engineering Department, New Jersey Institute of Technology, Newark, NJ 07102, United States.

Spray drying is one of the widely used manufacturing processes in pharmaceutical industry. While there are voluminous experimental studies pertaining to the impact of various process-formulation parameters on the quality attributes of spray dried powders such as particle size, morphology, density, and crystallinity, there is scant information available in the literature regarding process scale-up. Here, we first analyze salient features of scale-up attempts in literature. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.03.047DOI Listing

Fluorescent Biocompatible Platinum-Porphyrin-Doped Polymeric Hybrid Particles for Oxygen and Glucose Biosensing.

Sci Rep 2019 Mar 22;9(1):5029. Epub 2019 Mar 22.

Discipline of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Khandwa Road, Indore, 453552, India.

Near infrared (NIR) fluorophores like Pt-porphyrin along with analyte specific enzymes require co-encapsulation in biocompatible and biodegradable carriers in order to be transformed into implantable biosensors for efficient and continuous monitoring of analytes in patients. The main objective of this research is to develop natural, biodegradable, biocompatible and a novel co-encapsulated system of Pt-porphyrin encapsulated polymeric nanoparticle and nano-micro hybrid carriers. A sequential emulsification-solvent evaporation and an air driven atomization technique was used for developing above matrices and testing them for fluorescence based oxygen and glucose biosensing. Read More

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http://dx.doi.org/10.1038/s41598-019-41326-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430792PMC

Sustained release paclitaxel-loaded core-shell-structured solid lipid microparticles for intraperitoneal chemotherapy of ovarian cancer.

Artif Cells Nanomed Biotechnol 2019 Dec;47(1):957-967

a Department of Precision Machinery and Precision Instrumentation, School of Engineering Science , University of Science and Technology of China , Hefei , P.R.China.

The current clinical paradigm for ovarian cancer treatment has a poor prognosis, partially due to the efficacy and toxicity concerns associated with the available chemotherapeutic formulations. To overcome these limitations, we have designed core-shell-structured paclitaxel (PTX) laden solid lipid microparticles (PTX-SLMPs) for intraperitoneal treatment of ovarian cancer. A single-step coaxial electro hydrodynamic atomization (CEHDA) process has been explored to synthesize core-shell structure of PTX-SLMPs with the particle size of 1. Read More

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http://dx.doi.org/10.1080/21691401.2019.1576705DOI Listing
December 2019
1 Read

Tailoring surface acoustic wave atomisation for cryo-electron microscopy sample preparation.

Lab Chip 2019 Apr;19(8):1378-1385

Department of Mechanical and Aerospace Engineering, Monash University, Clayton, Victoria, Australia.

Surface acoustic wave (SAW) atomisation has been widely explored for use in pharmacological delivery, hence performance is characterised predominately in terms of droplet size and maximum delivery of fluid, to ensure sufficient dosage is delivered to the right location. For the application of cryo electron microscopy grid preparation, however, what is required is the transfer of very little fluid onto the grid in a well-defined manner. To meet this requirement, the analysis of SAW atomisation needs to focus on very different characteristics. Read More

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http://dx.doi.org/10.1039/c8lc01347kDOI Listing

Clinical effects of lentinan combined with budesonide inhalation in treating acute exacerbation of chronic obstructive pulmonary disease under mechanical ventilation.

Authors:
Jian Sun Gang Zhao

Exp Ther Med 2019 Mar 3;17(3):1503-1508. Epub 2019 Jan 3.

Department of Emergency, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, P.R. China.

In the present study, the clinical efficacy of the immune modulator lentinan combined with inhalation of the corticosteroid budesonide in treating acute exacerbation of chronic obstructive pulmonary disease (AECOPD) under mechanical ventilation was assessed. A total of 72 cases of AECOPD treated at Shanghai Jiao Tong University Affiliated Sixth People's Hospital (Shanghai, China) between June 2016 and September 2017 were enrolled. The AECOPD patients were randomly divided into an experimental group (n=36) and a control group (n=36). Read More

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http://dx.doi.org/10.3892/etm.2019.7149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395996PMC
March 2019
2 Reads

Comparison of the Pharmacokinetic Properties of Naloxone Following the Use of FDA-Approved Intranasal and Intramuscular Devices Versus a Common Improvised Nasal Naloxone Device.

J Clin Pharmacol 2019 Mar 12. Epub 2019 Mar 12.

National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD, USA.

For more than a decade, first responders and the general public have been able to treat suspected opioid overdoses using an improvised nasal naloxone device (INND) constructed from a prefilled syringe containing 2 mg of naloxone (1 mg/mL) attached to a mucosal atomization device. In recent years, the U.S. Read More

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http://dx.doi.org/10.1002/jcph.1401DOI Listing

Effect of molecular weight on the properties of chitosan films prepared using electrostatic spraying technique.

Carbohydr Polym 2019 May 16;212:197-205. Epub 2019 Feb 16.

SJTU-OSU Innovation Center for Environmental Sustainability and Food Control, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China; Department of Food Science and Technology, 100 Wiegand Hall, Oregon State University, Corvallis, OR 97331-6702, USA. Electronic address:

Chitosan (CH) films were prepared with different number-average molecular weight (MW, ca. 6.55, 12. Read More

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http://dx.doi.org/10.1016/j.carbpol.2019.02.048DOI Listing

The correlation factor model for the exchange-correlation energy and its application to transition metal compounds.

J Chem Phys 2019 Feb;150(8):084107

Département de Chimie, Université de Montréal, C.P. 6128 Succursale A, Montréal, Québec H3C 3J7, Canada.

In the recently developed correlation factor (CF) model [Precechtelova et al., J. Chem. Read More

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http://dx.doi.org/10.1063/1.5083840DOI Listing
February 2019

Sizing silver nanoparticles in chicken meat using direct slurry sampling graphite furnace atomic absorption spectrometry.

Anal Bioanal Chem 2019 Feb 27. Epub 2019 Feb 27.

Institute of Analytical and Bioanalytical Chemistry, Ulm University, Albert-Einstein-Allee 11, 89081, Ulm, Germany.

Recently, graphite furnace atomic absorption spectrometry (GFAAS) has been suggested as a tool for detection and sizing of metal nanoparticles (NPs) providing several advantages, such as direct analysis of solid samples, high sample throughput, and robust and cost-efficient instrumentation. For this purpose, evaluation of newly introduced criteria of the absorbance signal, namely, atomization delay (t) and atomization rate (k), is performed. However, in real samples, NPs are typically stabilized by either engineered coating reagents or natural materials and occur in unknown concentration. Read More

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http://dx.doi.org/10.1007/s00216-019-01606-7DOI Listing
February 2019

Mono- and Bi-Phasic Cellulose Acetate Micro-Vectors for Anti-Inflammatory Drug Delivery.

Pharmaceutics 2019 Feb 18;11(2). Epub 2019 Feb 18.

Department of Engineering for Innovation, University of Salento, Lecce 73100, Italy.

In recent years, different processing technologies have been engineered to fabricate capsules or particles with peculiar properties (e.g., swelling, pH-sensitive response) at the micro and sub-micrometric size scale, to be used as carriers for controlled drug and molecular release. Read More

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http://dx.doi.org/10.3390/pharmaceutics11020087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409530PMC
February 2019
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Surface-Degradable Drug-Eluting Stent with Anticoagulation, Antiproliferation, and Endothelialization Functions.

Biomolecules 2019 02 18;9(2). Epub 2019 Feb 18.

Key Laboratory of Advanced Technology of Materials of Education Ministry, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.

Drug-eluting stents (DES) have been widely applied for saving the life of patients with coronary artery diseases (CADs). However, conventional polymers such as polylactic acid (PLA) and poly (lactic-co-glycolic acid) (PLGA), which are widely applied for drug-eluting stents studies, have serious bulk erosion problems, like high local acidity and poor mechanical properties. Instead, we chose surface erosion polymer poly (1, 3-trimethylene carbonate) (PTMC) as a drug carrier in this study. Read More

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http://www.mdpi.com/2218-273X/9/2/69
Publisher Site
http://dx.doi.org/10.3390/biom9020069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406385PMC
February 2019
6 Reads

High-resolution continuum source graphite furnace atomic absorption spectrometry for screening elemental impurities in drugs to adhere to the new international guidelines.

Talanta 2019 May 23;197:20-27. Epub 2018 Dec 23.

Department of Chemistry, Federal University of Santa Maria, Av. Roraima, 1000, 97105-900 Santa Maria, Brazil.

New guidelines for the limits of elemental impurities in drug products were introduced by the International Council for Harmonization in 2014. While the guidelines define a limit for each element, the complete quantification of the 24 elements included is, in fact, unnecessary. An accurate "pass/fail" test to determine whether the threshold was exceeded or not could be valuable in this context. Read More

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http://dx.doi.org/10.1016/j.talanta.2018.12.068DOI Listing

Coaxial Electrohydrodynamic Atomization for the Production of Drug-Loaded Micro/Nanoparticles.

Micromachines (Basel) 2019 Feb 14;10(2). Epub 2019 Feb 14.

School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410013, China.

Coaxial electrohydrodynamic atomization (CEHDA) presents a promising technology for preparing drug-loaded micro/nanoparticles with core-shell structures. Recently, CEHDA has attracted tremendous attention based on its specific advantages, including precise control over particle size and size distribution, reduced initial burst release and mild preparation conditions. Moreover, with different needles, CEHDA can produce a variety of drug-loaded micro/nanoparticles for drug delivery systems. Read More

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http://dx.doi.org/10.3390/mi10020125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412865PMC
February 2019
1 Read

Partial combination of composite strategy and the B3LYP functional for the calculation of enthalpies of formation.

J Mol Model 2019 Feb 12;25(3):62. Epub 2019 Feb 12.

Instituto de Química, Universidade Estadual de Campinas, Barão Geraldo, 13083-970 Campinas, PO Box 6154, São Paulo, Brazil.

The B3LYP functional was re-optimized using partially composite methods for the calculation of standard enthalpies of formation. Two initial methods (B3LYP-MCM1 and B3LYP-MCM2) differing in the type and number of optimized parameters were analyzed using B3LYP/6-31 + G(2df,p) as the reference energy. For the first method (B3LYP-MCM1), the exchange-correlation and higher-level correction parameters (HLC) were optimized and for the second method (B3LYP-MCM2), in addition to the previous parameters, scaling of the basis functions responsible for large errors in the enthalpy of formation were also optimized. Read More

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http://link.springer.com/10.1007/s00894-019-3952-4
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http://dx.doi.org/10.1007/s00894-019-3952-4DOI Listing
February 2019
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Experimental characterization of multi-nozzle atomization interference for dust reduction between hydraulic supports at a fully mechanized coal mining face.

Environ Sci Pollut Res Int 2019 Apr 11;26(10):10023-10036. Epub 2019 Feb 11.

College of Mining and Safety Engineering, Shandong University of Science and Technology, Qingdao, 266590, China.

To analyze the distribution pattern concerning multi-nozzle interference spray particle granularity between hydraulic supports, the present study conducts atomization interference experimental characterization for three types of nozzles used in coal mines based on a Doppler laser interference spray dust suppression simulation experimental system. The results indicate that for single-nozzle atomization, the impact of spray pressure on spray droplet size is gradually subdued, and a spray pressure of 8 MPa yields the best result; compared with single-nozzle spray, the multi-nozzle atomization interference effect can downsize the spray field overlapping zone, leading to an improved uniformity of overall spray particle distribution. As the spray field overlapping coefficient k increases, the particle size of the interference spray field decreases first and then increases. Read More

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http://dx.doi.org/10.1007/s11356-019-04413-wDOI Listing
April 2019
6 Reads

Toxicological analysis of Pb and Cd by ET AAS in local anaesthetics for teething (teething gels) based on herbs available in Polish pharmacies.

J Trace Elem Med Biol 2019 Mar 10;52:18-21. Epub 2018 Nov 10.

Department of Analytical Chemistry, Faculty of Chemistry, Jagiellonian University in Kraków, Gronostajowa 2, 30-387 Kraków, Poland; School of Biomedicine, Far Eastern Federal University, Sukhanova 8, Vladivostok, 690950, Russia.

Studies related to the toxicological analyses of metallic impurities in pharmaceuticals (drugs) is an important issue but there is a lack of refereed literature around the safety of teething remedies from herbal origin related to toxic metals impurities. In this article, the levels of Pb and Cd were measured in samples of local anaesthetics for teething (gels) based on herbs. This article was motivated by the fact that Pb and Cd are relevant toxic metals that may cause an adverse effect in babies even at low levels. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.11.005DOI Listing
March 2019
2 Reads

[Entrustable professional activities: a new proposal for the evaluation of the medical competencies].

Rev Med Chil 2018 Sep;146(9):1064-1069

Escuela de Medicina, Facultad de Medicina, Universidad Diego Portales, Santiago, Chile.

Medical education migrated from a practice-based to a knowledge-based discipline after the publication of the Flexner Report. The emergence of competence-based medical education led to a greater standardization of teaching, allowing students to integrate knowledge, skills and attitudes for the execution of a given task. A challenge is the evaluation of learning. Read More

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http://dx.doi.org/10.4067/s0034-98872018000901064DOI Listing
September 2018

Prediction of atomization energy using graph kernel and active learning.

J Chem Phys 2019 Jan;150(4):044107

Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.

Data-driven prediction of molecular properties presents unique challenges to the design of machine learning methods concerning data structure/dimensionality, symmetry adaption, and confidence management. In this paper, we present a kernel-based pipeline that can learn and predict the atomization energy of molecules with high accuracy. The framework employs Gaussian process regression to perform predictions based on the similarity between molecules, which is computed using the marginalized graph kernel. Read More

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http://dx.doi.org/10.1063/1.5078640DOI Listing
January 2019
1 Read

Approaching the Volcano Top: Iridium/Silicon Nanocomposites as Efficient Electrocatalysts for the Hydrogen Evolution Reaction.

ACS Nano 2019 Mar 4;13(3):2786-2794. Epub 2019 Feb 4.

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Joint International Research Laboratory of Carbon-Based Functional Materials and Devices , Soochow University , 199 Ren'ai Road , Suzhou 215123 , Jiangsu , P.R. China.

Electrolysis of water to generate hydrogen is an important issue for the industrial production of green and sustainable energy. The best electrocatalyst currently available for the hydrogen evolution reaction (HER) is platinum. We herein show that iridium can be manipulated to achieve a record high HER activity surpassing platinum in every aspect: a lower overpotential at any given current density, a higher current density, and mass activity for all bias potentials applied and a catalyst cost reduction of 50% for the same hydrogen generation rate. Read More

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http://dx.doi.org/10.1021/acsnano.8b07572DOI Listing
March 2019
3 Reads

Separation characteristics of hydrophilic ionic liquids from ionic liquids-water solution by ultrasonic atomization.

Ultrason Sonochem 2019 Jan 6. Epub 2019 Jan 6.

Department of Advanced Materials & Chemical Engineering, Hannam University, Daejeon 34054, Republic of Korea. Electronic address:

Ionic liquids (ILs) have attracted much attention as promising alternatives for volatile organic solvents. Although the applications of ILs have been found in a diverse range of fields, there are a limited number of methods for the recovery of ILs so far. As an efficient separation method, therefore, ultrasonic atomization has been attempted to recover hydrophilic ILs, [Bmim][BF], from ILs-water solution. Read More

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http://dx.doi.org/10.1016/j.ultsonch.2019.01.004DOI Listing
January 2019

An Improved Empirical Model for Flood Discharge Atomization and Its Application to Optimize the Flip Bucket of the Nazixia Project.

Int J Environ Res Public Health 2019 01 24;16(3). Epub 2019 Jan 24.

State Key Laboratory of Hydraulic Engineering Simulation and Safety, Tianjin University, 92 Weijin Road, Nankai District, Tianjin 300072, China.

Flood discharge atomization is a serious challenge that threatens the daily lives of the residents around the dam area as well as the safety of the water conservancy project. This research aims to improve the prediction accuracy of the stochastic splash model. A physical model test with four types of flip bucket is conducted to obtain the hydraulic parameters of the impinging outer edge of the water jet, the relationship of the splashing droplet diameter with its corresponding velocity, and the spatial distribution of the downstream nappe wind. Read More

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http://dx.doi.org/10.3390/ijerph16030316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388201PMC
January 2019
2.063 Impact Factor

Atomization and Changes in Chemical Composition by Laser Ablation in Liquid prior to Determination of Trace Elements in Gallium Nitride.

Anal Sci 2019 Jan 18. Epub 2019 Jan 18.

Faculty of Science and Engineering, Department of Applied Chemistry, Chuo University.

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http://dx.doi.org/10.2116/analsci.18P542DOI Listing
January 2019
1 Read

Rebounding suppression of droplet impact on hot surfaces: effect of surface temperature and concaveness.

Authors:
S Jowkar M R Morad

Soft Matter 2019 Jan;15(5):1017-1026

Aerospace Engineering Department, Sharif University of Technology, 14588-89694, Iran.

When a droplet impinges on a hot surface it is crucial to increase the contact time or decrease the rebounding distance if the heat transfer between the droplet and the surface is important. This will be more sensitive when the temperature regime is above the Leidenfrost values. The focus of the present experimental study is on the maximum height of drop bouncing after impinging on flat and semi-cylindrical concave surfaces, in particular in terms of surface temperature. Read More

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http://dx.doi.org/10.1039/c8sm02271bDOI Listing
January 2019

Machine learning model for non-equilibrium structures and energies of simple molecules.

Authors:
E Iype S Urolagin

J Chem Phys 2019 Jan;150(2):024307

Department of Computer Science, BITS Pilani Dubai Campus, Dubai, United Arab Emirates.

Predicting molecular properties using a Machine Learning (ML) method is gaining interest among research as it offers quantum chemical accuracy at molecular mechanics speed. This prediction is performed by training an ML model using a set of reference data [mostly Density Functional Theory (DFT)] and then using it to predict properties. In this work, kernel based ML models are trained (using Bag of Bonds as well as many body tensor representation) against datasets containing non-equilibrium structures of six molecules (water, methane, ethane, propane, butane, and pentane) to predict their atomization energies and to perform a Metropolis Monte Carlo (MMC) run with simulated annealing to optimize molecular structures. Read More

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http://dx.doi.org/10.1063/1.5054968DOI Listing
January 2019
1 Read

Transferable density functional tight binding for carbon, hydrogen, nitrogen, and oxygen: Application to shock compression.

J Chem Phys 2019 Jan;150(2):024107

Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA.

A new parameterization for density functional tight binding (DFTB) theory, 31, has been developed for molecules containing carbon, hydrogen, nitrogen, and oxygen. Optimal values for the Hubbard s, on-site energies, and the radial dependences of the bond integrals and repulsive potentials were determined by numerical optimization using simulated annealing to a modest database of -calculated atomization energies and interatomic forces. The transferability of the optimized DFTB parameterization has been assessed using the CHNO subset of the QM-9 database [R. Read More

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http://dx.doi.org/10.1063/1.5063385DOI Listing
January 2019
1 Read

Size-Dependent Phase Transformation during Gas Atomization Process of Cu⁻Sn Alloy Powders.

Materials (Basel) 2019 Jan 12;12(2). Epub 2019 Jan 12.

State Key Laboratory of Advanced Welding and Joining, School of Materials Science and Engineering, Harbin Institute of Technology at Shenzhen, Shenzhen 518055, China.

For binary element atomization, it is essential to investigate the phase transformation from liquid to solid as a functions of the droplet sizes, as well as the reaction competitiveness, during gas atomizing solidification of their nuclei. In the present work, a series of phase transformations of undercooled Cu (60.9 wt. Read More

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http://dx.doi.org/10.3390/ma12020245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356303PMC
January 2019
1 Read

Preparation of pH-responsive DOX-loaded chitosan nanoparticles using supercritical assisted atomization with an enhanced mixer.

Int J Pharm 2019 Mar 9;558:82-90. Epub 2019 Jan 9.

College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.

Chemotherapeutics are used extensively in cancer and encapsulating the drug in nanoparticles is an effective method to enhance therapeutic efficacy and reduce side effect. In this work, DOX-loaded chitosan nanoparticles were prepared using supercritical fluid assisted atomization introduced by a hydrodynamic cavitation mixer (SAA-HCM) from aqueous solution. The influences of solution concentration, CO/solution ratio, mixer pressure, chitosan/DOX ratio and chitosan molecular weight on particle morphologies and sizes were investigated in detail. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2018.12.077DOI Listing
March 2019
1 Read

Process Optimization and Upscaling of Spray-Dried Drug-Amino acid Co-Amorphous Formulations.

Pharmaceutics 2019 Jan 9;11(1). Epub 2019 Jan 9.

Department of Pharmacy, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.

The feasibility of upscaling the formulation of co-amorphous indomethacin-lysine from lab-scale to pilot-scale spray drying was investigated. A 2² full factorial design of experiments (DoE) was employed at lab scale. The atomization gas flow rate (F, from 0. Read More

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http://dx.doi.org/10.3390/pharmaceutics11010024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358949PMC
January 2019
2 Reads

Simultaneous determination of iron and nickel as contaminants in multimineral and multivitamin supplements by solid sampling HR-CS GF AAS.

Talanta 2019 Apr 6;195:745-751. Epub 2018 Dec 6.

Departamento de Química, Universidade Federal de Santa Maria, 97111-900 Santa Maria, RS, Brazil. Electronic address:

A methodology to assay simultaneously iron and nickel present as contaminants in multimineral and multivitamin supplements was investigated. High-resolution continuum source graphite furnace atomic absorption spectrometry and direct solid sample analysis were used. Measurements were done with the secondary lines of Fe (352. Read More

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http://dx.doi.org/10.1016/j.talanta.2018.12.010DOI Listing

Machine vision analysis on abnormal respiratory conditions of mice inhaling particles containing cadmium.

Ecotoxicol Environ Saf 2019 Apr 18;170:600-610. Epub 2018 Dec 18.

Gansu Key Laboratory of Biomonitoring and Bioremediation for Environmental Pollution, School of Life Sciences, Lanzhou University, Lanzhou 730000, China.

Inhalable environmental toxicants can induce pulmonary malfunction resulting abnormal respiratory conditions. The traditional methods currently available to detect the respiratory condition of animals rely on differential pressure transducers and signal amplifiers. In comparison, current machine vision application requires little hardware. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2018.12.022DOI Listing

Evaluation of the effects of spray drying parameters for producing cubosome powder precursors.

Eur J Pharm Biopharm 2019 Feb 18;135:44-48. Epub 2018 Dec 18.

Department of Micro- and Nanotechnology, Technical University of Denmark, Oersteds Plads 345C, 2800 Kgs. Lyngby, Denmark.

Vaccines provide great benefit for global health, but are insufficiently distributed in developing countries due to high costs of manufacturing and limited storage stability. Spray drying formulations of peptide-based vaccines offer a promising strategy to reduce production costs and improve unrefrigerated storage stability. This design of experiments investigated how adjusting spray drying parameters (inlet temperature, atomization pressure, feed rate and aspiration rate) affects residual moisture and reconstitution properties of the powder product, and morphology and size of the rehydrated particles. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09396411183107
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http://dx.doi.org/10.1016/j.ejpb.2018.12.008DOI Listing
February 2019
7 Reads

Fatty acids characterization and oxidative stability of spray dried designer egg powder.

Lipids Health Dis 2018 Dec 13;17(1):282. Epub 2018 Dec 13.

Department of Chemistry, Faculty of Physical Sciences, Government College University, Faisalabad, Pakistan.

Background: Designer eggs (DEs) have gained positive importance in maintaining cholesterol level, triglyceride profile and protection towards cardiovascular diseases due to the presence of essential fatty acids (EFAs) such as omega-3 (or) n-3 fatty acids. However, extreme heat conditions effect the quality as well as quantity of EFAs during the production of designer egg dried powder (DEDP). Therefore, the main mandate of research was the development of DEDP and determination of spray drying conditions impact on fatty acids composition of DEDP samples. Read More

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http://dx.doi.org/10.1186/s12944-018-0931-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293535PMC
December 2018
1 Read
2.219 Impact Factor

[Effects of aerosol inhalation on respiratory mechanical parameters under different ventilation patterns and ventilator parameters].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Nov;30(11):1036-1040

Department of Critical Care Medicine, Affiliated Qingdao Municipal Hospital of Qingdao University, Qingdao 266071, Shandong, China. Corresponding author: Qu Yan, Email:

Objective: To investigate the effects of aerosol inhalation on respiratory mechanical parameters under different ventilation patterns and ventilator parameters in patients on mechanical ventilation and simulated model of aqualung in vitro.

Methods: (1) Clinical research: the patients needed sedative undergoing mechanical ventilation admitted to intensive care unit (ICU) of Qingdao Municipal Hospital from January 2016 to January 2018 were enrolled. They were randomly divided into volume controlled ventilation (VCV) group and pressure controlled ventilation (PCV) group according to random number table. Read More

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http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2018.011.005DOI Listing
November 2018
9 Reads

Identifying critical process steps to protein stability during spray drying using a vibrating mesh or a two-fluid nozzle.

Eur J Pharm Sci 2019 Feb 3;128:152-157. Epub 2018 Dec 3.

Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, the Netherlands. Electronic address:

The aim of this study was to identify critical steps to protein stability during spray drying using two different nozzle types: a vibrating mesh nozzle and a standard two-fluid nozzle in a Büchi B-90 spray dryer. l-Lactic dehydrogenase was used as a model protein as it is a heat and shear stress sensitive protein. Trehalose was used as excipient because of its excellent stabilizing capacities. Read More

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http://dx.doi.org/10.1016/j.ejps.2018.11.027DOI Listing
February 2019
5 Reads

Enhancement Method of Surface Acoustic Wave-Atomizer Efficiency for Olfactory Display.

J Vis Exp 2018 11 14(141). Epub 2018 Nov 14.

Tokyo Institute of Technology.

Since olfaction is an important sense in human interfaces, we have developed an olfactory display using a surface acoustic wave (SAW) atomizer and micro-dispensers. In this olfactory display, the efficiency of atomization is important in order to avoid smell persistence problems often encountered in human olfactory interfaces. Thus, the SAW device is coated with amorphous Teflon film to change the substrate nature from hydrophilic to hydrophobic. Read More

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http://dx.doi.org/10.3791/58409DOI Listing
November 2018

An improved molecular partitioning scheme for numerical quadratures in density functional theory.

J Chem Phys 2018 Nov;149(20):204111

Department of Chemistry and Center for Integrated Protein Science (CIPSM), University of Munich (LMU), D-81377 München, Germany.

We present a modification to Becke's molecular partitioning scheme [A. D. Becke, J. Read More

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http://dx.doi.org/10.1063/1.5049435DOI Listing
November 2018

Dissociations of water ions after valence and inner-valence ionization.

J Chem Phys 2018 Nov;149(20):204307

Department of Physics, University of Gothenburg, Origovägen 6B, 412 96 Gothenburg, Sweden.

Energy selected and mass-resolved electron-ion coincidence spectra of heavy water have been recorded for ionization energies from 18 to 35 eV. Dissociation from the BB state produces both O and D at energies near their thermodynamic thresholds in addition to the known products D and OD. The relative yields of O, OD, and D in the BB state breakdown diagram are modulated by the vibrational structure of the B-state population, implying incomplete energy equilibration before fragmentation. Read More

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http://aip.scitation.org/doi/10.1063/1.5055593
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http://dx.doi.org/10.1063/1.5055593DOI Listing
November 2018
1 Read

Boosting Quantum Machine Learning Models with a Multilevel Combination Technique: Pople Diagrams Revisited.

J Chem Theory Comput 2019 Mar 12;15(3):1546-1559. Epub 2019 Feb 12.

Institute of Physical Chemistry and National Center for Computational Design and Discovery of Novel Materials (MARVEL), Department of Chemistry , University of Basel , Klingelbergstrasse 80 , 4056 Basel , Switzerland.

Inspired by Pople diagrams popular in quantum chemistry, we introduce a hierarchical scheme, based on the multilevel combination (C) technique, to combine various levels of approximations made when molecular energies are calculated. When combined with quantum machine learning (QML) models, the resulting CQML model is a generalized unified recursive kernel ridge regression that exploits correlations implicitly encoded in training data composed of multiple levels in multiple dimensions. Here, we have investigated up to three dimensions: chemical space, basis set, and electron correlation treatment. Read More

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http://dx.doi.org/10.1021/acs.jctc.8b00832DOI Listing
March 2019
3 Reads

Engineering and Development of Chitosan-Based Nanocoatings for Ocular Contact Lenses.

J Pharm Sci 2019 Apr 1;108(4):1540-1551. Epub 2018 Dec 1.

The Leicester School of Pharmacy, De Montfort University, Leicester LE1 1BH, UK. Electronic address:

This article reports on electrohydrodynamic atomization to engineer on-demand novel coatings for ocular contact lenses. A formulation approach was adopted to modulate the release of timolol maleate (TM) using chitosan and borneol. Polymers polyvinylpyrrolidone and poly (N-isopropylacrylamide) were utilized to encapsulate TM and were electrically atomized to produce optimized, stationary contact lens coatings. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223549183078
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http://dx.doi.org/10.1016/j.xphs.2018.11.036DOI Listing
April 2019
25 Reads
2.590 Impact Factor

Fabrication of sliver/graphitic carbon nitride photocatalyst with enhanced visible-light photocatalytic efficiency through ultrasonic spray atomization.

J Colloid Interface Sci 2019 Mar 22;538:15-24. Epub 2018 Nov 22.

Faculty of Materials Science and Engineering, Kunming University of Science and Technology, Kunming 650093, China.

A composite photocatalyst, sliver/graphitic carbon nitride/pre-treated carbon fiber paper (Ag/g-CN/t-CFP), has been innovatively designed and successfully fabricated by loading Ag and g-CN species on t-CFP using the combined methods of thermal polymerization and improved electroless plating (IEP) through ultrasonic spray atomization (USA). A micro-droplet system, USA is able to eliminate the adverse influence of concentration gradient effectively. The samples obtained were carefully characterized in terms of morphology, phase, chemical structure, and optical performance. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00219797183139
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http://dx.doi.org/10.1016/j.jcis.2018.11.078DOI Listing
March 2019
15 Reads

Microstructure and Texture of -Type Bi-Sb-Te Alloy by Using Gas-Atomization and Extrusion Processes.

J Nanosci Nanotechnol 2019 Apr;19(4):2236-2239

Advanced Materials Engineering, Kongju National University, Chungchengnam-do 330-717, Korea.

Microstructure and texture of -type 75%Sb₂Te₃-25%Bi₂Te₃ alloy fabricated by using gas-atomization and extrusion processes was investigated. The microstructure of the gas-atomized powders exhibited fine grains with needle shape. After hot extrusion, grain size was characterized by fine and equiaxed grains due to dynamic recrystallization by severe deformation. Read More

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https://www.ingentaconnect.com/content/10.1166/jnn.2019.1600
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http://dx.doi.org/10.1166/jnn.2019.16000DOI Listing
April 2019
1 Read

Effect of terbutaline combined with budesonide in treatment of bronchial asthma and rehabilitation nursing.

Pak J Pharm Sci 2018 Sep;31(5(Special)):2249-2255

Respiratory of Zuanshiwan hospital district, The Second Hospital of Dalian Medical University, Dalian, China.

Terbutaline aerosol and budesonide suspension are commonly used in the treatment of bronchial asthma, and budesonide suspension has local high efficiency and anti-inflammatory effects. In this paper, we selected 240 patients with bronchial asthma and randomly divided them into two groups. The experimental group was treated with atomization inhalation of terbutaline, after 5 minutes interval, nebulized inhalation of budesonide was performed. Read More

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September 2018
32 Reads

Conversion of PLGA nanoparticle suspensions into solid dosage forms via fluid bed granulation and tableting.

Eur J Pharm Biopharm 2019 Jan 14;134:77-87. Epub 2018 Nov 14.

Institute of Pharmaceutical Technology and Biopharmacy, University of Muenster, Corrensstraße 48, 48149 Münster, Germany. Electronic address:

Incorporating poorly soluble drugs into polymeric nanoparticles is a widely investigated approach to improve their biopharmaceutical performance. Poly(DL-lactide-co-glycolide) (PLGA) nanoparticle formulations have previously been tested and recommended as drug carriers for peroral administration of poorly soluble porphyrin derivatives intended for photodynamical therapy. Based on those PLGA formulations the present study investigates conventional techniques like fluid bed granulation and tableting for conversion of such polymeric nanoparticle suspensions into solid dosage forms. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09396411183086
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http://dx.doi.org/10.1016/j.ejpb.2018.11.011DOI Listing
January 2019
14 Reads

The Effect of Pretreatment (Spray Drying) on the Yield and Selected Nutritional Components of Whole Camel Milk Powder.

J Food Sci 2018 Dec 15;83(12):2983-2991. Epub 2018 Nov 15.

Dept. of Food Science and Technology, Faculty of Agriculture, Jomo Kenyatta Univ. of Agriculture and Technology, P.O. Box 62000, Nairobi 00200, Kenya.

The effect of spray drying on the composition of camel milk powder was evaluated. A full factorial experimental design was used to see the effects of inlet temperature (160 °C, 140 °C, and 120 °C), atomization pressure (800, 600, and 400 bar) and feed flow rate (5, 4, and 3 rev/s) on cyclone and vitamin C recoveries. Principal components analysis (PCA) was used to check classification of spray dried whole camel milk powders based on their processing conditions and multiple correspondence analysis (MCA) on the fatty acid profiles. Read More

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http://doi.wiley.com/10.1111/1750-3841.14361
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http://dx.doi.org/10.1111/1750-3841.14361DOI Listing
December 2018
11 Reads

Micropipette-Based Microfluidic Device for Monodisperse Microbubbles Generation.

Micromachines (Basel) 2018 Aug 4;9(8). Epub 2018 Aug 4.

Department of Exact and Earth Sciences (DCET), University of the State of Bahia (UNEB), Salvador, BA 41150-000, Brazil.

Microbubbles have various applications including their use as carrier agents for localized delivery of genes and drugs and in medical diagnostic imagery. Various techniques are used for the production of monodisperse microbubbles including the Gyratory, the coaxial electro-hydrodynamic atomization (CEHDA), the sonication methods, and the use of microfluidic devices. Some of these techniques require safety procedures during the application of intense electric fields (e. Read More

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http://dx.doi.org/10.3390/mi9080387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187383PMC
August 2018
12 Reads

[Establishment of arsenic speciation analysis method and application in rice].

Zhonghua Yu Fang Yi Xue Za Zhi 2018 Oct;52(10):994-1002

Department of inspection, Centre for Disease Control and Prevention of Guangdong, Guangzhou 510300, China.

A new ion exchange column technology was used to establish an efficient and sensitive method for the detection of inorganic arsenic. Based on the new As Specia Fast Column, the pretreatment methods, liquid phase separation and mass spectrometry determination conditions of inorganic arsenic in rice were optimized. Finally, arsenic compounds were separated by As Specia Fast Column and detected by liquid chromatography inductively coupled plasma mass spectrometry. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-9624.2018.10.006DOI Listing
October 2018

Essential and toxic elements in honeys consumed in Italy.

J Toxicol Environ Health A 2018 2;81(21):1123-1134. Epub 2018 Nov 2.

a Department of Biomolecular Sciences , Urbino University , Urbino , Italy.

The aim of this study was to determine the levels of iron (Fe), manganese (Mn), chromium (Cr), copper (Cu), zinc (Zn), mercury (Hg), cadmium (Cd) and lead (Pb) in several types of honey purchased from the local consumer markets in Central Italy by Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Lead and Cd were also determined by Atomic Absorption Spectrometry with graphite tube atomization (AAS-GTA). The degree of humidity, sugar content, pH, free acidity, combined acidity (lactones) and total acidity were also measured. Read More

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http://dx.doi.org/10.1080/15287394.2018.1520160DOI Listing
November 2018