22,332 results match your criteria Atlas of the oral and maxillofacial surgery clinics of North America[Journal]


lncRNA SNHG8 Promotes the Tumorigenesis and Metastasis by Sponging miR-149-5p and Predicts Tumor Recurrence in Hepatocellular Carcinoma.

Cell Physiol Biochem 2018 7;51(5):2262-2274. Epub 2018 Dec 7.

Background/aims: Long noncoding RNAs (lncRNAs) are aberrantly expressed in multiple malignant tumors involved in tumor growth and metastasis. Accumulating data show that small nucleolar RNA host gene (SNHG) 1/12/20 plays a key role in the progression of hepatocellular carcinoma (HCC). However, the molecular mechanisms by which SNHG8 contributes to HCC remain elusive and merit exploration. Read More

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December 2018

Bioinformatic analysis of the prognostic value of the lncRNAs encoding snoRNAs in hepatocellular carcinoma.

Biofactors 2018 Dec 8. Epub 2018 Dec 8.

Department of Oncology Radiotherapy, Henan Provincial People's Hospital, Zhengzhou, Henan, China.

Some lncRNAs can encode small nucleolar RNAs (snoRNAs), called small nucleolar RNA host genes (SNHGs), which exert diverse regulatory effects on cellular processes. In this study, using RNA-seq and survival data in the Cancer Genome Atlas (TCGA)-Liver Hepatocellular Carcinoma (LIHC), we examined the expression profile of some SNHG genes and explored their prognostic value in hepatocellular carcinoma (HCC). Level-3 RNA-sequencing data, the clinicopathological and survival data of patients with primary HCC were downloaded from the UCSC Xena browser (https://xenabrowser. Read More

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December 2018
2 Reads

An Updated Gene Atlas for Maize Reveals Organ-Specific and Stress-Induced Genes.

Plant J 2018 Dec 7. Epub 2018 Dec 7.

Department of Plant Biology, Michigan State University, East Lansing, MI, 48824, USA.

Maize(Zea mays L.), a model species for genetic studies, is one of the two most important crop species worldwide.The genome sequence of the reference genotype, B73, representative of the stiff stalk heterotic group was recently updated (AGPv4) using long-read sequencing and optical mapping technology. Read More

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December 2018
2 Reads

Tamoxifen therapy benefit predictive signature combining with prognostic signature in surgical-only ER-positive breast cancer.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of General Surgery, Huai'an Second People's Hospital, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China.

Tamoxifen treatment is important assistant for estrogen-receptor-positive breast cancer (BRCA) after resection. This study aimed to identify signatures for predicting the prognosis of patients with BRCA after tamoxifen treatment. Data of gene-specific DNA methylation (DM), as well as the corresponding clinical data for the patients with BRCA, were obtained from The Cancer Genome Atlas and followed by systematic bioinformatics analyses. Read More

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December 2018

Long noncoding RNA HOXC13-AS positively affects cell proliferation and invasion in nasopharyngeal carcinoma via modulating miR-383-3p/HMGA2 axis.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Zhengzhou University No. 1, Zhengzhou, Henan, China.

Long noncoding RNAs have been reported to be important regulators in numerous cancers. In this study, we found that HOXC13 antisense RNA (HOXC13-AS) was highly expressed in head and neck squamous carcinoma (HNSC) tissues in The Cancer Genome Atlas database. Nasopharyngeal carcinoma (NPC) belongs to HNSC. Read More

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December 2018
2 Reads

Identification of prognostic miRNA biomarkers for predicting overall survival of colon adenocarcinoma and bioinformatics analysis: A study based on The Cancer Genome Atlas database.

J Cell Biochem 2018 Dec 9. Epub 2018 Dec 9.

Department of Pharmacy, First Affiliated Hospatial of Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Object: This study was conducted to identify the prognostic microRNA (miRNA) for the prediction of survival in colon adenocarcinoma (CA).

Methods: miRNA profiling of patients with CA was downloaded from The Cancer Genome Atlas (TCGA) database. After data processing, univariate Cox regression was performed to select potential prognostic miRNAs. Read More

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December 2018
1 Read

Integrative analysis of DNA methylation and gene expression identify a six epigenetic driver signature for predicting prognosis in hepatocellular carcinoma.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Surgery, Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

DNA methylation is a crucial regulator of gene transcription in the etiology and pathogenesis of hepatocellular carcinoma (HCC). Thus, it is reasonable to identify DNA methylation-related prognostic markers. Currently, we aimed to make an integrative epigenetic analysis of HCC to identify the effectiveness of epigenetic drivers in predicting prognosis for HCC patients. Read More

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December 2018

TMEM196 hypermethylation as a novel diagnostic and prognostic biomarker for lung cancer.

Mol Carcinog 2018 Dec 11. Epub 2018 Dec 11.

Institute of Toxicology, College of Preventive Medicine, Third Military Medical University (Army Medical University), Chongqing, PR China.

Emerging evidences have revealed tumor-specific gene methylation is considered to be a promising non-invasive biomarker for many different types of cancers. This study was determined whether TMEM196 gene hypermethylation and downregulation are considered to be promising biomarkers for early diagnosis and prognosis in lung cancer. Methylation status was detected with methylation-specific PCR. Read More

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December 2018

Centromere protein U promotes cell proliferation, migration and invasion involving Wnt/β-catenin signaling pathway in non-small cell lung cancer.

Eur Rev Med Pharmacol Sci 2018 Nov;22(22):7768-7777

Department of Oncology, Affiliated Jining No. 1 People's Hospital of Jining Medical University, Jining Medical University, Jingning, Shandong, China.

Objective: The purpose of this study was to examine centromere protein U (CENPU) expression in non-small cell lung cancer (NSCLC) and identify the clinical values of CENPU, as well as investigate the potential molecular mechanisms in NSCLC.

Patients And Methods: The expression levels and clinical significance of CENPU were systematically evaluated in human protein atlas datasets and TCGA datasets. CENPU protein expression was studied by Western blotting. Read More

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November 2018

A SENtence Supramodal Areas AtlaS (SENSAAS) based on multiple task-induced activation mapping and graph analysis of intrinsic connectivity in 144 healthy right-handers.

Brain Struct Funct 2018 Dec 7. Epub 2018 Dec 7.

Univ. Bordeaux, IMN, UMR 5293, 33000, Bordeaux, France.

We herein propose an atlas of 32 sentence-related areas based on a 3-step method combining the analysis of activation and asymmetry during multiple language tasks with hierarchical clustering of resting-state connectivity and graph analyses. 144 healthy right-handers performed fMRI runs based on language production, reading and listening, both with sentences and lists of over-learned words. Sentence minus word-list BOLD contrast and left-minus-right BOLD asymmetry for each task were computed in pairs of homotopic regions of interest (hROIs) from the AICHA atlas. Read More

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December 2018

Bioinformatics analysis of the interactions among lncRNA, miRNA and mRNA expression, genetic mutations and epigenetic modifications in hepatocellular carcinoma.

Mol Med Rep 2018 Dec 5. Epub 2018 Dec 5.

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China.

The present study aimed to investigate the regulatory networks involving long noncoding RNA (lncRNA), microRNA (miRNA), mRNA, genetic mutations and epigenetic modifications in hepatocellular carcinoma (HCC) by analyzing datasets from The Cancer Genome Atlas (TCGA) database. TCGA was mined, and miRNAs, lncRNAs and mRNAs that were differentially expressed in HCC were identified using R software. A gene regulatory network was constructed using Cytoscape software. Read More

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December 2018
1 Read

High expression of ACTL8 is poor prognosis and accelerates cell progression in head and neck squamous cell carcinoma.

Mol Med Rep 2018 Dec 3. Epub 2018 Dec 3.

Department of Neurosurgery, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, P.R. China.

Actin‑like protein 8 (ACTL8) is a member of the cancer‑testis antigens (CTA) family, which is mainly localized in the cytoplasm and generally expressed in the testis. The association between ACTL8 and various types of cancer, including glioblastoma and breast cancer, has previously been demonstrated. However, whether ACTL8 is involved in the development of head and neck squamous cell carcinoma (HNSCC) remains unknown. Read More

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December 2018

MAPT (Tau) expression is a biomarker for an increased rate of survival for low‑grade glioma.

Oncol Rep 2018 Nov 28. Epub 2018 Nov 28.

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.

The association of MAPT (Tau) with various tauopathies and other neurological disorders has long been established. However, the role of microtubule‑associated protein Tau (MAPT) expression in brain cancer is largely unknown. To determine whether MAPT expression is related to low‑grade glioma (LGG) survival rates, RNASeq data representing samples from the Cancer Genome Atlas (TCGA) were assessed. Read More

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November 2018

Long non‑coding RNA MLK7‑AS1 promotes proliferation in human colorectal cancer via downregulation of p21 expression.

Mol Med Rep 2018 Nov 28. Epub 2018 Nov 28.

Department of Thoracic Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning 110042, P.R. China.

Current studies have highlighted long non‑coding RNAs (lncRNAs) as critical regulators in various cancers, including colorectal cancer (CRC). By utilizing publicly available data from The Cancer Genome Atlas dataset, MLK7 antisense RNA 1 (MLK7‑AS1) was identified as a novel lncRNA that correlated with CRC progression. The results of reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) revealed a significant upregulation of MLK7‑AS1 in both CRC tissue samples and cell lines. Read More

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November 2018

Ten genes associated with MGMT promoter methylation predict the prognosis of patients with glioma.

Oncol Rep 2018 Dec 4. Epub 2018 Dec 4.

Department of Neurosurgery, The Fourth Affiliated Hospital of Zhejiang University Medical College, Yiwu, Zhejiang 322000, P.R. China.

Glioma originates from the glial cells of the spine or brain, and promoter methylation of O6‑methylguanine‑DNA methyltransferase (MGMT) can promote the chemosensitivity of glioma. The present study aimed to reveal the key genes implicated in MGMT promoter methylation in patients with glioma. RNA‑sequencing data and methylation data for glioma were extracted from The Cancer Genome Atlas database. Read More

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December 2018
1 Read

Metabolic pathways associated with right ventricular adaptation to pulmonary hypertension: 3D analysis of cardiac magnetic resonance imaging.

Eur Heart J Cardiovasc Imaging 2018 Dec 7. Epub 2018 Dec 7.

MRC London Institute of Medical Sciences, Du Cane Road, London, UK.

Aims: We sought to identify metabolic pathways associated with right ventricular (RV) adaptation to pulmonary hypertension (PH). We evaluated candidate metabolites, previously associated with survival in pulmonary arterial hypertension, and used automated image segmentation and parametric mapping to model their relationship to adverse patterns of remodelling and wall stress.

Methods And Results: In 312 PH subjects (47. Read More

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December 2018

Natriuretic Peptides in Post-mortem Brain Tissue and Cerebrospinal Fluid of Non-demented Humans and Alzheimer's Disease Patients.

Front Neurosci 2018 26;12:864. Epub 2018 Nov 26.

Department of Radiology, Leiden University Medical Center, Leiden, Netherlands.

Animal studies suggest the involvement of natriuretic peptides (NP) in several brain functions that are known to be disturbed during Alzheimer's disease (AD). However, it remains unclear whether such findings extend to humans. In this study, we aimed to: (1) map the gene expression and localization of NP and their receptors (NPR) in human post-mortem brain tissue; (2) compare the relative amounts of NP and NPR between the brain tissue of AD patients and non-demented controls, and (3) compare the relative amounts of NP between the cerebrospinal fluid (CSF) of AD patients and non-demented controls. Read More

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November 2018

Post-traumatic os odontoideum - case presentation and literature review.

Trauma Case Rep 2018 Dec 27;18:46-51. Epub 2018 Nov 27.

Soroka University Medical Center, Department of Spine Surgery, Beer-Sheva, Israel.

Os odontoideum is a rare condition. Nevertheless this condition was described by Giacomini in 1886. It is defined radiologicaly as an oval or round-shaped ossicle of variable size with smooth circumferential cortical margins representing the odontoid process that has no continuity with the body of C2. Read More

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December 2018

Deep Brain Stimulation Surgery for Parkinson Disease Coexisting With Communicating Hydrocephalus: A Case Report.

Front Neurol 2018 23;9:1011. Epub 2018 Nov 23.

Hospital Clínico, Universidad de Chile, Santiago, Chile.

We report a successful bilateral globus pallidus internus-deep brain stimulation (GPi-DBS) for a Parkinson disease (PD) patient with idiopathic normal pressure hydrocephalus (INPH) and an unusually long anterior commissure-posterior commissure (AC-PC) line. A 54-year-old man presented with a history of 3 months of severe shuffling gait, rigidity, slow movements of the left side limbs, and difficulty managing finances. A brain MRI revealed marked ventriculomegaly (Evans index = 0. Read More

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November 2018

Effect of poplar-type propolis on oxidative stability and rheological properties of O/W emulsions.

Saudi Pharm J 2018 Dec 29;26(8):1073-1082. Epub 2018 May 29.

Department of Chemistry and Pharmacy, MeditBio, Faculty of Science and Technology, University of Algarve, Campus de Gambelas, 8005-139 Faro, Portugal.

Propolis is known to possess antioxidant activity. However, there is no information on this activity in emulsions O/W. The protective effect of propolis on the oxidation and rheological properties of emulsions O/W containing wheat germ and almond oils was evaluated. Read More

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December 2018

Identification and validation of a four-miRNA (miRNA-21-5p, miRNA-9-5p, miR-149-5p, and miRNA-30b-5p) prognosis signature in clear cell renal cell carcinoma.

Cancer Manag Res 2018 15;10:5759-5766. Epub 2018 Nov 15.

First Department of Chemotherapy, Medical Oncology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, P.R. China,

Purpose: Clear cell renal cell carcinoma (ccRCC) is one of the most common cancers with high mortality worldwide. However, biomarkers for predicting prognosis in ccRCC are limited. In this study, we attempted to identify potential prognostic biomarkers of ccRCC. Read More

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November 2018

Enolase-1 serves as a biomarker of diagnosis and prognosis in hepatocellular carcinoma patients.

Cancer Manag Res 2018 15;10:5735-5745. Epub 2018 Nov 15.

Precision Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China,

Background: Hepatocellular carcinoma (HCC) is an aggressive malignancy with high incidence rate and poor prognosis. Enolase-1 (ENO1), a key glycolytic enzyme, has been implicated in the tumorigenesis of various cancers. However, its diagnostic value and clinical significance in HCC are unclear. Read More

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November 2018
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Evaluation of antioxidant, diuretic, and wound healing effect of Tulkarm honey and its effect on kidney function in rats.

Vet World 2018 Nov 25;11(10):1491-1499. Epub 2018 Oct 25.

Laboratory of Physiology, Pharmacology and Environmental Health, Faculty of Sciences, Dhar El Mehraz, BP 1796 Atlas, University Sidi Mohamed Ben Abdallah, Fez 30 000, Morocco.

Aim: The composition and activity of honey depend on its floral origin. Honey collected from Tulkarm was evaluated for physicochemical property and antioxidant content as well as a diuretic and wound healing activity. Its effect on kidney function was evaluated and compared with furosemide. Read More

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November 2018

FAM46B inhibits cell proliferation and cell cycle progression in prostate cancer through ubiquitination of β-catenin.

Exp Mol Med 2018 Dec 10;50(12):163. Epub 2018 Dec 10.

Department of Urology, Shanghai Sixth People's Hospital East Affiliated to Shanghai University of Medicine & Health Sciences, Shanghai, 201306, China.

FAM46B is a member of the family with sequence similarity 46. Little is known about the expression and functional role(s) of FAM46B in prostate cancer (PC). In this study, the expression of FAM46B expression in The Cancer Genome Atlas, GSE55945, and an independent hospital database was measured by bioinformatics and real-time PCR analysis. Read More

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December 2018

Pan-cancer characterisation of microRNA across cancer hallmarks reveals microRNA-mediated downregulation of tumour suppressors.

Nat Commun 2018 12 7;9(1):5228. Epub 2018 Dec 7.

Department of Oncology, Medical Sciences Division, University of Oxford, Oxford, OX3 7DQ, UK.

microRNAs are key regulators of the human transcriptome across a number of diverse biological processes, such as development, aging and cancer, where particular miRNAs have been identified as tumour suppressive and oncogenic. In this work, we elucidate, in a comprehensive manner, across 15 epithelial cancer types comprising 7316 clinical samples from the Cancer Genome Atlas, the association of miRNA expression and target regulation with the phenotypic hallmarks of cancer. Utilising penalised regression techniques to integrate transcriptomic, methylation and mutation data, we find evidence for a complex map of interactions underlying the relationship of miRNA regulation and the hallmarks of cancer. Read More

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December 2018

CNOT3 targets negative cell cycle regulators in non-small cell lung cancer development.

Oncogene 2018 Dec 10. Epub 2018 Dec 10.

Cell Signal Unit, Okinawa Institute of Science and Technology Graduate University, Onna-son, Okinawa, Japan.

Lung cancer is one of the major causes of cancer death and clarification of its molecular pathology is highly prioritized. The physiological importance of mRNA degradation through the CCR4-NOT deadenylase has recently been highlighted. For example, mutation in CNOT3, a gene coding for CNOT3 subunit of the CCR4-NOT complex, is found to be associated with T-cell acute lymphoblastic leukemia, T-ALL, though its contribution to other cancers has not been reported. Read More

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December 2018

Integrin Subunit beta 8 (ITGB8) Upregulation Is an Independent Predictor of Unfavorable Survival of High-Grade Serous Ovarian Carcinoma Patients.

Med Sci Monit 2018 Dec 10;24:8933-8940. Epub 2018 Dec 10.

Anesthesia Center, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China (mainland).

BACKGROUND ITGB8 encodes a β subunit of integrin (integrin β8), which is upregulated in some types of cancer. In the current study, we examined the expression profile of ITGB8 in serous ovarian cancer (SOVC) and investigated its potential as an independent prognostic indicator for overall survival (OS) and recurrence-free survival (RFS) in high-grade SOVC. MATERIAL AND METHODS A secondary study was conducted based on genomic and survival data in large online databases, including the Gene Expression Omnibus (GEO), the Human Protein Atlas (HPA), and the Cancer Genome Atlas-Ovarian cancer (TCGA-OV). Read More

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December 2018

Atlas of Ultrasound-Guided Regional Anesthesia, 3rd Edition.

Authors:
Harald Breivik

Scand J Pain 2018 Dec 7. Epub 2018 Dec 7.

Faculty of Medicine, University of Oslo, Oslo, Norway; and Oslo University Hospital, Department of Anaesthesiology and Department of Pain Management and Research, Oslo University Hospital, Oslo, Norway.

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December 2018

Atlas of Common Pain Syndromes, 4th Edition.

Authors:
Harald Breivik

Scand J Pain 2018 Dec 7. Epub 2018 Dec 7.

Faculty of Medicine, University of Oslo, Oslo, Norway.

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December 2018

Comprehensive Transcriptional Profiling of the Gastrointestinal Tract of Ruminants from Birth to Adulthood Reveals Strong Developmental Stage Specific Gene Expression.

G3 (Bethesda) 2018 Dec 10. Epub 2018 Dec 10.

University of Edinburgh

One of the most significant physiological challenges to neonatal and juvenile ruminants is the development and establishment of the rumen. Using a subset of RNA-Seq data from our high-resolution atlas of gene expression in sheep () we have provided the first comprehensive characterisation of transcription of the entire gastrointestinal (GI) tract during the transition from pre-ruminant to ruminant. The dataset comprises 164 tissue samples from sheep at four different time points (birth, one week, 8 weeks and adult). Read More

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December 2018

AACR White Paper: Shaping the Future of Cancer Prevention - A Roadmap for Advancing Science and Public Health.

Cancer Prev Res (Phila) 2018 Dec;11(12):735-778

Division of Cancer Prevention & Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX.

The recent pace, extent, and impact of paradigm-changing cancer prevention science has been remarkable. The American Association for Cancer Research (AACR) convened a 3-day summit, aligned with five research priorities: (i) Precancer Atlas (PCA). (ii) Cancer interception. Read More

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December 2018

Cloud deployment of high-resolution medical image analysis with TOMAAT.

IEEE J Biomed Health Inform 2018 Dec 5. Epub 2018 Dec 5.

Background: Deep learning has been recently applied to a multitude of computer vision and medical image analysis problems. Although recent research efforts have improved the state of the art, most of the methods cannot be easily accessed, compared or used by other researchers or clinicians. Even if developers publish their code and pre-trained models on the internet, integration in stand-alone applications and existing workflows is often not straightforward, especially for clinical research partners. Read More

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December 2018

Occipital to Vertebral Artery Bypass to Stop Transient Ischemic Attacks Caused by Traumatic Vertebral Artery Dissection: A Case Report.

World Neurosurg 2018 Dec 6. Epub 2018 Dec 6.

Department of Neurosurgery, 687-4 Nadogaya, Kashiwa, Chiba 277-0032 Japan.

Background: Ischemic symptoms caused by traumatic vertebral artery dissection after cervical maneuvers are treated medically and surgically. This is a report of the infrequently documented occipital to vertebral artery bypass to stop the transient ischemic attacks following traumatic vertebral artery dissection.

Case Description: A 33-year-old man presented with a sudden right posterior neck pain following a sudden neck movement, accompanied by left lower quadrant anopsia and rotational vertigo. Read More

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December 2018

A deep learning based method for large-scale classification, registration, and clustering of in-situ hybridization experiments in the mouse olfactory bulb.

J Neurosci Methods 2018 Dec 6. Epub 2018 Dec 6.

Bates College, Program in Neuroscience, Lewiston, ME 04240, United States. Electronic address:

Background: The Allen Mouse Brain Atlas allows study of the brain's molecular anatomy at cellular scale, for thousands of. To fully leverage this resource, one must register histological images of brain tissue -- a task made challenging by the brain's structural complexity and heterogeneity, as well as inter-experiment variability.

New Method: We have developed a deep-learning based methodology for classification and registration of thousands of sections of brain tissue, using the mouse olfactory bulb (OB) as a case study. Read More

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December 2018

Fatal atlantoaxial dislocation due to an odontoid synchondrosis fracture in a child with chromosome 9 abnormality: A case report.

J Forensic Leg Med 2018 Nov 29;61:92-96. Epub 2018 Nov 29.

Department of Legal Medicine, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba city, Chiba Prefecture, 260-8670, Japan; Department of Forensic Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

A 5-year-old boy with a chromosome-9 abnormality and multiple external and visceral malformations was found in cardiopulmonary arrest during a regular visit to the hospital; he did not respond to cardiopulmonary resuscitation and died. An odontoid process fracture and calcification and fibrosis of the muscles around the superior cervical vertebra were observed during the autopsy. Postmortem computed tomography revealed an anterior dislocation of the atlas; odontoid synchondrosis fracture; and delayed, incomplete bony fusion of the odontoid process relative to his age. Read More

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November 2018

Low DMT1 Expression Associates With Increased Oxidative Phosphorylation and Early Recurrence in Hepatocellular Carcinoma.

J Surg Res 2019 Feb;234:343-352

Center for Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, New York; Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, New York; Department of Surgery, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, The State University of New York, Buffalo, New York. Electronic address:

Background: Despite a high rate of recurrences, long-term survival can be achieved after the resection of hepatocellular carcinoma (HCC) with effective local treatment. Discovery of adverse prognostic variables to identify patients with high risk of recurrence could improve the management of HCC. Accumulating evidence showing a link between carcinogenesis and increased expression of iron import proteins and intracellular iron prompted us to investigate a role of divalent metal-ion transporter-1 (DMT1) that binds and regulates a variety of divalent metals in HCC. Read More

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February 2019

Correlation between EZH2 and CEP55 and lung adenocarcinoma prognosis.

Pathol Res Pract 2018 Nov 24. Epub 2018 Nov 24.

Department of Cardiothoracic Surgery, Sun Yet-Sen Memoral Hospital Sun Yet-Sen University, Guangzhou, 510000, Guangdong Province, PR China. Electronic address:

Objective: Recently, accumulated evidence indicates that the enhancer of zeste homologue 2 (EZH2) is highly expressed in a wide range of cancer types, including NSCLC. The downstream genes regulated by EZH2 were screened using bioinformatics analysis. This study aimed to analyse the correlation between the downstream genes of EZH2 and the prognosis of lung adenocarcinoma. Read More

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November 2018

Potential Role of microRNA-183 as a Tumor Suppressor in Hepatocellular Carcinoma.

Cell Physiol Biochem 2018 6;51(5):2065-2072. Epub 2018 Dec 6.

Department of General Surgery of East District, The Second Hospital of Hebei Medical University, Shijiazhuang,

Background/aims: Disseminated tumors, known as metastases, are responsible for ninety-percent of mortality due to cancer. Epithelial to mesenchymal transition, a phenomenon required for morphological conversion of non-motile discoid shaped epithelial cells to highly motile spindle-shaped mesenchymal cells, is thought to be a pre-requisite for metastatic progression. Metastasis-associated 1 (MTA1) protein is a prime inducer of EMT and metastatic progression in all solid tumors including hepatocellular carcinoma (HCC). Read More

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December 2018
9 Reads

Dynamic functional connectivity during task performance and rest predicts individual differences in attention across studies.

Neuroimage 2018 Dec 3;188:14-25. Epub 2018 Dec 3.

Department of Psychology, Yale University, USA; Department of Neuroscience, Yale School of Medicine, USA; Interdepartmental Neuroscience Program, Yale University, USA.

Dynamic functional connectivity (DFC) aims to maximize resolvable information from functional brain scans by considering temporal changes in network structure. Recent work has demonstrated that static, i.e. Read More

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December 2018
1 Read

The C2 Pedicle Width, Pars Length, and Laminar Thickness in Concurrent Ipsilateral Ponticulus Posticus and High-Riding Vertebral Artery: A Radiological Computed Tomography Scan-Based Study.

Asian Spine J 2018 Dec 7. Epub 2018 Dec 7.

Department of Orthopaedics, P D Hinduja National Hospital & MRC, Mumbai, India.

Study Design: Retrospective radiological study.

Purpose: We aimed to determine the prevalence of ponticulus posticus (PP) and high-riding vertebral artery (HRVA) occurring simultaneously on the same side (PP+HRVA) and in cases of PP+HRVA, to assess C2 radio-anatomical measurements for C2 pars length, pedicle width, and laminar thickness.

Overview Of Literature: PP and HRVA predispose individuals to vertebral artery injuries during atlantoaxial fixation. Read More

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December 2018

Gene landscape and correlation between B-cell infiltration and programmed death ligand 1 expression in lung adenocarcinoma patients from The Cancer Genome Atlas data set.

PLoS One 2018 6;13(12):e0208459. Epub 2018 Dec 6.

Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.

Tumor-infiltrating lymphocytes are related to positive clinical prognoses in numerous cancer types. Programmed death ligand 1 (PD-L1), a mediator of the PD-1 receptor, plays an inhibitory role in cancer immune responses. PD-L1 upregulation can impede infiltrating T-cell functions in lung adenocarcinoma (LUAD), a lung cancer subtype. Read More

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December 2018
1 Read

Monitoring the elimination of human African trypanosomiasis: Update to 2016.

PLoS Negl Trop Dis 2018 Dec 6;12(12):e0006890. Epub 2018 Dec 6.

World Health Organization, Control of Neglected Tropical Diseases, Innovative and Intensified Disease Management, Geneva, Switzerland.

Background: Human African trypanosomiasis (HAT) is a neglected tropical disease targeted for elimination 'as a public health problem' by 2020. The indicators to monitor progress towards the target are based on the number of reported cases, the related areas and populations exposed at various levels of risk, and the coverage of surveillance activities. Based on data provided by the National Sleeping Sickness Control Programmes (NSSCP), Non-Governmental Organizations (NGOs) and research institutions-and assembled in the Atlas of HAT-the World Health Organization (WHO) provides here an update to 2016 for these indicators, as well as an analysis of the epidemiological situation. Read More

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December 2018
1 Read

Bayesian analysis of retinotopic maps.

Elife 2018 Dec 6;7. Epub 2018 Dec 6.

Department of Psychology, New York University, New York, United States.

Human visual cortex is organized into multiple retinotopic maps. Characterizing the arrangement of these maps on the cortical surface is essential to many visual neuroscience studies. Typically, maps are obtained by voxel-wise analysis of fMRI data. Read More

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December 2018
3 Reads

Downregulation of fibroblast growth factor 5 inhibits cell growth and invasion of human nonsmall-cell lung cancer cells.

J Cell Biochem 2018 Dec 5. Epub 2018 Dec 5.

Department of Cardio-Thoracic, Wujin People's Hospital of Changzhou, Changzhou, China.

The morbidity and mortality rates of nonsmall-cell lung cancer (NSCLC) have increased in recent years. We aimed to explore the biological role of fibroblast growth factor 5 (FGF5) in NSCLC. We first established that the expression of FGF5 was increased in NSCLC tissues compared with the normal adjacent tissues. Read More

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December 2018

Identification of Five Genes as a Potential Biomarker for Predicting Progress and Prognosis in Adrenocortical Carcinoma.

J Cancer 2018 31;9(23):4484-4495. Epub 2018 Oct 31.

Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan 430071, P.R. China.

Background: Adrenocortical carcinoma (ACC) is a limited endocrine fatality with a minor diagnosis and rare remedial options. The progressive and predictive meaning of message RNA (mRNA) expression oddity in ACC has been studied extensively in recent years. However, differences in measurement platforms and lab protocols as well as small sample sizes can render gene expression levels incomparable. Read More

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October 2018
2 Reads

Comprehensive Analysis of Somatic Mutation in Clear Cell Renal Cell Carcinoma to Explore Potential Mechanisms .

J Cancer 2018 18;9(22):4108-4116. Epub 2018 Oct 18.

Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.

Aim of this study was to comprehensively analyze BRCA1-associated protein-1 () somatic mutation in clear cell renal cell carcinoma (ccRCC) and explore potential therapeutic pathways and molecules. In this study, we analyzed 445 ccRCC cases from The Cancer Genome Atlas (TCGA). Comprehensive analysis including survival, transcriptome and methylation between mutated and wild-type cases was performed using bioinformatics tools . Read More

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October 2018

Living with obsessive-compulsive disorder (OCD): a South African narrative.

Int J Ment Health Syst 2018 1;12:73. Epub 2018 Dec 1.

2SU/UCT MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa.

Background: Obsessive-compulsive disorder (OCD) is a highly prevalent and debilitating psychiatric disorder known to interfere with several life domains. Yet little is known about the subjective experiences of living with OCD amongst South Africans and more so, the ways in which it impacts daily functioning and quality of life (QOL).

Methods: The aim of this study was to explore daily functioning and QOL among South African adults living with OCD. Read More

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December 2018
1 Read

Overexpression of RALY promotes migration and predicts poor prognosis in hepatocellular carcinoma.

Cancer Manag Res 2018 9;10:5559-5572. Epub 2018 Nov 9.

Organ Transplant Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, Guangdong, China,

Introduction: RALY plays a critical role in promoting invasiveness and is associated with poor prognosis in different types of cancers. However, the prognostic value of RALY and its precise role in hepatocellular carcinoma (HCC) remain unknown.

Materials And Methods: We detected the expression of RALY in 127 clinical HCC tissue samples and seven HCC cell lines by immunohistochemical staining and Western blotting. Read More

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November 2018

Chromatin interactions and expression quantitative trait loci reveal genetic drivers of multimorbidities.

Nat Commun 2018 12 5;9(1):5198. Epub 2018 Dec 5.

The Liggins Institute, The University of Auckland, Auckland, 1023, New Zealand.

Clinical studies of non-communicable diseases identify multimorbidities that suggest a common set of predisposing factors. Despite the fact that humans have ~24,000 genes, we do not understand the genetic pathways that contribute to the development of multimorbid non-communicable disease. Here we create a multimorbidity atlas of traits based on pleiotropy of spatially regulated genes. Read More

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December 2018

Long non-coding RNA C5orf66-AS1 promotes cell proliferation in cervical cancer by targeting miR-637/RING1 axis.

Cell Death Dis 2018 Dec 5;9(12):1175. Epub 2018 Dec 5.

Jiangsu Engineering Research Center for Tumor Immunotherapy, Changzhou, 213003, People's Republic of China.

Long non-coding RNA (lncRNA) plays an important role in the development of human malignant tumours. Recently, an increasing number of lncRNAs have been identified and investigated in a variety of tumours. However, the expression pattern and biological function of lncRNAs in cervical cancer still remain largely unexplored. Read More

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December 2018