2,775 results match your criteria Atla-alternatives To Laboratory Animals[Journal]


A comparative study about the immunomodulatory effects of tramadol and metamizole in a murine model of postoperative ileus.

Lab Anim 2019 Mar 24:23677219832919. Epub 2019 Mar 24.

Department of Surgery, University of Bonn, Bonn Germany.

Postoperative ileus (POI) is a common complication after abdominal surgery characterized by motility disturbances leading to increased morbidity and mortality in surgical patients. Intestinal manipulation of the murine small bowel is an established animal model resulting in an increased postsurgical inflammation within the intestinal muscular externa and a delayed gastrointestinal transit. Some analgesics have been shown to affect inflammation. Read More

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http://dx.doi.org/10.1177/0023677219832919DOI Listing

Diet-regulated behavior: FVB/N mice fed a lean diet exhibit increased nocturnal bouts of aggression between littermates.

Lab Anim 2019 Mar 16:23677219834582. Epub 2019 Mar 16.

5 College of Public Health Epidemiology and Biostatistics, The University of Georgia, Athens, GA, USA.

The hyperactive FVB/N inbred mouse strain is widely used for transgenic research applications, although rarely for behavioral studies. These mice have visual impairments via retinal degeneration, but are considered highly intelligent and rely largely on olfaction. While investigating diet-induced obesity in autotaxin transgenic FVB/N mice, we observed an increase in the necessity for male, but not female, cage separations. Read More

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http://dx.doi.org/10.1177/0023677219834582DOI Listing
March 2019
1 Read

Success of embryo transfer in mice with freshly collected and cryopreserved two-cell embryos with different genetic backgrounds correlated with the number of transferred embryos: A 5-year retrospective analysis.

Lab Anim 2019 Mar 13:23677219832922. Epub 2019 Mar 13.

Institute for Laboratory Animal Science, Hannover Medical School, Germany.

Embryo transfer of pre-implantation embryos to surrogate dams is a key technique for the hygienic sanitation of strains, cryopreservation, in vitro fertilization, genetic modification and engineering. However, the effects of several parameters, such as the number of transferred embryos, on the success of embryo transfer are not well studied. In this retrospective study, we reanalysed 1320 embryo transfers of two-cell embryos originating from genetically altered donors, which were performed under routine conditions in our facility over a period of 5 years. Read More

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http://dx.doi.org/10.1177/0023677219832922DOI Listing

Occurrence of diseases in fish used for experimental research.

Lab Anim 2019 Mar 5:23677219830441. Epub 2019 Mar 5.

2 Department of Veterinary Sciences, Experimental Ichthyopathology Center of Sicily, University of Messina, Italy.

The objective of the present study was to evaluate the occurrence of pathogens and diseases in laboratory fish over a 10-year period at the Centre for Experimental Fish Pathology of Sicily, University of Messina. This report also emphasizes the adverse effects of subclinical infections on research endpoints, as well as the importance of animal health with respect to welfare. Infections in fish used for research can alter experimental outcomes, increase the variability of data, and impede experimental reproducibility. Read More

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http://dx.doi.org/10.1177/0023677219830441DOI Listing

ECLAM AGM News.

Authors:
Janet Rodgers

Lab Anim 2019 Feb;53(1):103

ECLAM Secretariat, UK.

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http://dx.doi.org/10.1177/0023677218821309DOI Listing
February 2019

The FELASA 40 Years' Anniversary Awards Winners announced.

Authors:
J-P Mocho

Lab Anim 2019 Feb;53(1):97

Chair of the FELASA 2019 Scientific Committee, FELASA, UK.

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http://dx.doi.org/10.1177/0023677218820275DOI Listing
February 2019

VIII Jornada Científica de la Sociedad Española para las Ciencias del Animal de laboratorio (SECAL)/VIII Scientific Session of the Spanish Society of Laboratory Animal Sciences (SECAL).

Authors:
Elena Hevia

Lab Anim 2019 Feb;53(1):104-105

Head of Laboratory Animal Facility, Centro de Biología Molecular Severo Ochoa c/ Nicolás, Cabrera, 1 Campus de la Universidad Autónoma, 28049-Cantoblanco, Madrid, Spain.

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http://dx.doi.org/10.1177/0023677218821287DOI Listing
February 2019

Forschungsförderung der GV-SOLAS 2018.

Authors:
Ulrike Teichmann

Lab Anim 2019 Feb;53(1):98-99

Max-Planck-Institut für biophysikalische Chemie, Göttingen, Deutschland.

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http://dx.doi.org/10.1177/0023677218822194DOI Listing
February 2019

Development of an orthotopic syngeneic murine model of colorectal cancer for use in translational research.

Lab Anim 2019 Feb 13:23677219826165. Epub 2019 Feb 13.

2 Department of Molecular and Clinical Pharmacology, University of Liverpool, UK.

Improving outcomes in colorectal cancer requires more accurate in vivo modelling of the disease in humans, allowing more reliable pre-clinical assessment of potential therapies. Novel imaging techniques are necessary to improve the longitudinal assessment of disease burden in these models, reducing the number of animals required for translational studies. This report describes the development of an immune-competent syngeneic orthotopic murine model of colorectal cancer, utilising caecal implantation of CT26 cells stably transfected with the luciferase gene into immune-competent BALB/c mice, allowing serial bioluminescent imaging of cancer progression. Read More

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http://dx.doi.org/10.1177/0023677219826165DOI Listing
February 2019

Fasting of male mice - Effects of time point of initiation and duration on clinical chemistry parameters and animal welfare.

Lab Anim 2019 Feb 10:23677218824373. Epub 2019 Feb 10.

3 Section of Experimental Animal Models, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Kbh N, Denmark.

Fasting of mice is a common procedure, which can affect the outcome of the study as well as animal welfare. In this study, we assess the effects of fasting, fasting duration and fasting initiation time in relation to light schedule and present suggestions for optimization of fasting. Male C57BL/6NCrl mice were fasted for 0, 3, 6, 12, 18 and 24 hours initiated either in the light period (photophase) or the dark period (scotophase). Read More

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http://dx.doi.org/10.1177/0023677218824373DOI Listing
February 2019

Retrobulbar Sinus Injection of Doxorubicin is More Efficient Than Lateral Tail Vein Injection at Inducing Experimental Nephrotic Syndrome in Mice: A Pilot Study.

Lab Anim 2019 Jan 24:23677218824382. Epub 2019 Jan 24.

1 Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University Hospital Tübingen, Germany.

Doxorubicin-induced nephropathy in mice is a model for studying experimental nephrotic syndrome. It corresponds to puromycin aminonucleoside nephrosis in rats. In this model, susceptible 129 S1/SvImJ mice are administered a rapid intravenous injection that can be accomplished via either the lateral tail vein or the retrobulbar sinus. Read More

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http://dx.doi.org/10.1177/0023677218824382DOI Listing
January 2019
3 Reads

The role of gut microbiota in intestinal and liver diseases.

Lab Anim 2018 Dec 22:23677218818605. Epub 2018 Dec 22.

1 Institute of Microbiology, The Czech Academy of Sciences, Czech Republic.

The world-wide incidence of many immune-mediated and metabolic diseases, including those of the intestines and liver, is steadily increasing. Gut microbiota plays a central role in the pathogenesis of these diseases as it mediates environmental changes to the intestinal immune system. Various environmental factors including diet, food additives and medication also trigger the compositional and functional alterations of microbiota, that is, dysbiosis, and this dysbiosis is closely associated with many chronic inflammatory diseases. Read More

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http://dx.doi.org/10.1177/0023677218818605DOI Listing
December 2018
10 Reads

Acinetobacter species in laboratory mice: species survey and antimicrobial resistance.

Lab Anim 2018 Dec 19:23677218818598. Epub 2018 Dec 19.

1 Central Unit for Animal Research and Animal Welfare Affairs, University Hospital, Heinrich - Heine - University, Düsseldorf, Germany.

The extra-hospital epidemiology of Acinetobacter infections is a subject of debate. In recent years, the prevalence of animal multidrug-resistant Acinetobacter infections has increased considerably. The goal of the present study was to specify Acinetobacter species isolated from laboratory mice and to test them for their antimicrobial susceptibility. Read More

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http://dx.doi.org/10.1177/0023677218818598DOI Listing
December 2018

Corrigendum to Coagulation phenotype of wild-type mice on different genetic backgrounds.

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Lab Anim 2019 Feb 18;53(1):NP1-NP2. Epub 2018 Dec 18.

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http://dx.doi.org/10.1177/0023677218816944DOI Listing
February 2019

Characterization of inflammatory infiltrate of ulcerative dermatitis in C57BL/6NCrl-Tg(HMGA1P6)1Pg mice.

Lab Anim 2018 Dec 6:23677218815718. Epub 2018 Dec 6.

1 Department of Veterinary Medicine and Animal Production, University of Naples Federico II, Italy.

Ulcerative dermatitis (UD) is an idiopathic, spontaneous and progressive disease typically affecting C57BL/6 aged mice with an unknown aetiopathogenesis. For this study, we evaluated 25 cases of UD in C57BL/6NCrl-Tg(HMGA1P6)1Pg mice. Formalin-fixed, paraffin-embedded skin samples were submitted to morphological investigations. Read More

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http://dx.doi.org/10.1177/0023677218815718DOI Listing
December 2018
1 Read

A REDCap application that links researchers, animal facility staff and members of the IACUC in animal health monitoring.

Lab Anim 2018 Dec 8:23677218815723. Epub 2018 Dec 8.

6 Centro de Medicina Regenerativa Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Chile.

Research studies involving animal experimentation are regulated by the Institutional Animal Care and Use Committee (IACUC). To this end, the IACUC must integrate the information provided by the investigators of each preclinical study and the veterinarians from the animal facility in order to monitor and approve the process. Using a paper-based system to collect animal health and welfare data is a common, albeit time-consuming practice, prone to transcription and reading errors, not to mention inconvenient for veterinarians and investigators wishing to make timely and collaborative decisions when animal welfare is at risk. Read More

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http://dx.doi.org/10.1177/0023677218815723DOI Listing
December 2018

Comparison of pre-emptive butorphanol or metamizole with ketamine +medetomidine and s-ketamine + medetomidine anaesthesia in improving intraoperative analgesia in mice.

Lab Anim 2018 Dec 8:23677218815208. Epub 2018 Dec 8.

1 Centre of Preclinical Research, Technical University of Munich, Germany.

In accordance with the 'refinement' component of the 3Rs, the primary aim of this study was to investigate and compare ketamine + medetomidine (KM) and s-ketamine + medetomidine (SKM) anaesthetic protocols in C57BL/6J mice (both sexes). We sought to determine whether s-ketamine could provide adequate surgical tolerance at a 50% dose relative to that of ketamine racemate and whether antagonism of medetomidine could be initiated 15 min earlier. The second aim was to investigate the potential improvement in analgesia for both anaesthetic protocols by adding butorphanol or metamizole. Read More

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http://dx.doi.org/10.1177/0023677218815208DOI Listing
December 2018
1 Read

Anaesthetics and analgesics used in adult fish for research: A review.

Lab Anim 2018 Dec 4:23677218815199. Epub 2018 Dec 4.

1 Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro (UTAD), Portugal.

The number of fish used in research has increased in the last decades. Anaesthesia is required when fish must be held immobile and it is crucial to promote fish welfare, because these vertebrates can show signs of stress and/or pain during handling, transport, tagging, sampling and invasive procedures. The use of an inadequate anaesthetic protocol can compromise not only the welfare of the fish, but also the reliability of the research results. Read More

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http://dx.doi.org/10.1177/0023677218815199DOI Listing
December 2018

Reliability of behavioral tests in the middle cerebral artery occlusion model of rat.

Lab Anim 2018 Nov 27:23677218815210. Epub 2018 Nov 27.

1 Department of Rehabilitation Medicine, CHA University School of Medicine, Seongnam, Republic of Korea.

Stroke is one of the leading causes of death and disability worldwide, and its incidence is increasing. To overcome impairment from stroke, translational research for developing new therapeutic technologies has been conducted and middle cerebral artery occlusion (MCAo) in rat is the representative model. Since recovery from neurological impairment in contralateral limbs caused by brain damage is the major goal of treatment, behavioral tests that assess the relevant function are used. Read More

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http://dx.doi.org/10.1177/0023677218815210DOI Listing
November 2018
16 Reads

Effect of three opioid-based analgesic protocols on the perioperative autonomic-mediated cardiovascular response in sheep.

Lab Anim 2018 Nov 27:23677218815203. Epub 2018 Nov 27.

2 Department of Animal Medicine, Production and Health, University of Padua, Italy.

Few reports evaluate the clinical effects of opioids in sheep during experimental surgical procedures. Catecholamine-mediated haemodynamic changes resulting from surgical noxious stimulation are blunted by opioids. The aim of this study was to evaluate the efficacy of three opioid-based analgesic protocols in avoiding a 20% increase in heart rate (HR) and/or mean arterial blood pressure (MAP) during experimental intervertebral disk nucleotomy in sheep. Read More

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http://journals.sagepub.com/doi/10.1177/0023677218815203
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http://dx.doi.org/10.1177/0023677218815203DOI Listing
November 2018
1 Read

What does the GV-SOLAS actually do?

Lab Anim 2018 Dec;52(6):645

Die Gesellschaft für Versuchstierkunde/Society of Laboratory Animal Science (GV-SOLAS).

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http://dx.doi.org/10.1177/0023677218810969DOI Listing
December 2018
1 Read

Registration is opened for the 14th FELASA Congress!

Authors:
J-P Mocho

Lab Anim 2018 Dec;52(6):643-644

Chair of the FELASA 2019 Scientific Committee United Kingdom of Great Britain and Northern Ireland.

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http://dx.doi.org/10.1177/0023677218810968DOI Listing
December 2018

Meeting report GV-SOLAS annual conference 2018.

Authors:
Caroline Johner

Lab Anim 2018 Dec;52(6):646-647

Animal Welfare Consultant/Officer, Freiburg im Breisgau, Germany.

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http://dx.doi.org/10.1177/0023677218810970DOI Listing
December 2018

Coagulation phenotype of wild-type mice on different genetic backgrounds.

Lab Anim 2019 Feb 12;53(1):43-52. Epub 2018 Nov 12.

Shire, Vienna, Austria.

Genetically engineered mouse models are used to investigate beneficial treatment in haemophilia by comparison with wild-type mice. It has been recognized that wild-type and haemophilic mice of different genetic backgrounds show different bleeding phenotypes. We assessed ex-vivo coagulation parameters in nine wild-type substrains of 129S1/Sv, BALB/c and C57BL/6 mice applying thromboelastography (TEG), activated partial thromboplastin time (aPTT), prothrombin time (PT) and fibrinogen levels. Read More

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http://dx.doi.org/10.1177/0023677218811059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416704PMC
February 2019
11 Reads

Multiple refinements to the anaesthetic protocol for laparoscopic orthotopic kidney auto-transplantation in a pig model.

Lab Anim 2019 Feb 22;53(1):72-78. Epub 2018 Oct 22.

2 School of Medicine, The University of Western Australia, Australia.

Fifty-four pigs ( Sus scrofa, Large White cross) from a commercial pig farm were anaesthetised over a six-year period from October 2011. The procedural stages included initial instrumentation for intra-operative monitoring, laparoscopic nephrectomy, preparation of the kidney graft, orthotopic auto-transplantation by either a laparoscopic approach or an open surgical approach, and ligation of the contralateral ureter. During the evolution and establishment of this pig model multiple refinements were introduced: (1) a heat pad was changed to a circulating warm air blanket; (2) routine administration of anticholinesterase and antimuscarinic drugs for reversal of neuromuscular blockade; (3) a technique for urethral catheterisation was developed; (4) ultrasound guidance for placement of a central venous line was learned; (5) intravenous infusions of morphine and ketamine were instituted for a more stable and balanced anaesthetic protocol; and (6) post-operative monitoring was performed by two technical staff for at least the first six hours after extubation of the trachea. Read More

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http://dx.doi.org/10.1177/0023677218806444DOI Listing
February 2019

Informing efficient pilot development of animal trauma models through quality improvement strategies.

Lab Anim 2018 Oct 9:23677218802999. Epub 2018 Oct 9.

3 Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, USA.

Poor quality data in preclinical trials can result from inconsistent and unstandardized experimental processes. Unpredictable pre-intervention variability generates unreliable data, biases outcomes and results in needless waste of animals and resources. We applied Define-Measure-Analyse-Improve-Control (DMAIC) quality improvement processes to pilot development of a swine model of trauma, haemorrhagic shock and coagulopathy. Read More

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http://dx.doi.org/10.1177/0023677218802999DOI Listing
October 2018
1.120 Impact Factor

Fatal gastric distension in a gold thioglucose mouse model of obesity.

Lab Anim 2019 Feb 5;53(1):89-94. Epub 2018 Oct 5.

3 German Institute of Human Nutrition, Germany.

This case report addresses the problem of underreporting negative results and adverse side effects in animal testing. We present our findings regarding a hyperphagic mouse model associated with unforeseen high mortality. The results outline the necessity of reporting detailed information in the literature to avoid duplication. Read More

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http://journals.sagepub.com/doi/10.1177/0023677218803384
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http://dx.doi.org/10.1177/0023677218803384DOI Listing
February 2019
2 Reads

Automated monitoring of mouse feeding and body weight for continuous health assessment.

Lab Anim 2018 Oct 4:23677218797974. Epub 2018 Oct 4.

1 Department of Comparative Medicine, Stanford University, United States.

Routine health assessment of laboratory rodents can be improved using automated home cage monitoring. Continuous, non-stressful, objective assessment of rodents unaware that they are being watched, including during their active dark period, reveals behavioural and physiological changes otherwise invisible to human caretakers. We developed an automated feeder that tracks feed intake, body weight, and physical appearance of individual radio frequency identification-tagged mice in social home cages. Read More

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http://journals.sagepub.com/doi/10.1177/0023677218797974
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http://dx.doi.org/10.1177/0023677218797974DOI Listing
October 2018
2 Reads

Using preferred fluids and different reward schedules to motivate rhesus macaques ( Macaca mulatta) in cognitive tasks.

Lab Anim 2018 Oct 3:23677218801390. Epub 2018 Oct 3.

2 Institute of Neuroscience, Newcastle University, UK.

Rhesus macaques ( Macaca mulatta) used in behavioural neuroscience are often required to complete cognitively complex tasks, for which a high level of motivation is essential. To induce motivation, researchers may implement fluid-restriction protocols, whereby freely available water is limited, such that fluid can be used as a reward in the laboratory. A variety of different rewards and schedules are used, but there exists a lack of data assessing their effectiveness. Read More

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http://dx.doi.org/10.1177/0023677218801390DOI Listing
October 2018

Submit your abstract for the 14th FELASA Congress.

Lab Anim 2018 Oct;52(5):545

Chair of the FELASA 2019 Scientific Committee, FELASA, UK.

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http://dx.doi.org/10.1177/0023677218797059DOI Listing
October 2018

Update from the Editors.

Lab Anim 2018 Oct;52(5):538-539

3 Department Animal Welfare, University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1177/0023677218793845DOI Listing
October 2018

News from the European College of Laboratory Animal Medicine.

Authors:
Janet Rodgers

Lab Anim 2018 Oct;52(5):547

ECLAM Secretariat.

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http://dx.doi.org/10.1177/0023677218797582DOI Listing
October 2018

Establishing a successful rat model of duodenal- jejunal bypass: A detailed guide.

Lab Anim 2018 Sep 18:23677218797370. Epub 2018 Sep 18.

1 Division of Diabetes and Nutritional Sciences, King's College London, UK.

Gastric bypass surgery, an operation that restricts the stomach and bypasses the duodenum and part of the jejunum, results in major improvement or remission of type 2 diabetes. Duodenual-jejunal bypass was developed by one of the authors (FR) as an experimental, stomach-sparing variant of gastric bypass surgery to investigate weight-independent mechanisms of surgical control of diabetes. Duodenual-jejunal bypass has been shown to improve various aspects of glucose homeostasis in rodents and in humans, thus providing an experimental model for investigating mechanisms of action of surgery and elusive aspects of gastrointestinal physiology. Read More

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http://journals.sagepub.com/doi/10.1177/0023677218797370
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http://dx.doi.org/10.1177/0023677218797370DOI Listing
September 2018
2 Reads

Non-aversive photographic measurement method for subcutaneous tumours in nude mice.

Lab Anim 2018 Aug 21:23677218793450. Epub 2018 Aug 21.

1 Laboratorio de Animales de Experimentación, Facultad de Cs Veterinarias, UNLP, Argentina.

We have developed a new method for the measurement of subcutaneous tumour volume which consists in taking photographs of mice in their home cages, to refine the standard method of measurement with calipers. We consider this new method to be non-aversive, as it may be more compatible with mice behavioural preferences and, therefore, improve their welfare. Photographs are captured when mice voluntarily go into an acrylic tube containing graph paper that is later used as a scale. Read More

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http://dx.doi.org/10.1177/0023677218793450DOI Listing
August 2018
1 Read

Rapid acclimation of the cortisol stress response in adult turquoise killifish Nothobranchius furzeri.

Lab Anim 2018 Aug 20:23677218793441. Epub 2018 Aug 20.

2 Hagerman Fish Culture Experiment Station, Aquaculture Research Institute, University of Idaho, USA.

The turquoise killifish Nothobranchius furzeri is an increasingly popular model species for comparative vertebrate research, and the basic physiology including responses to stressful stimuli are of primary interest. We exposed adult killifish to a single or repeated periods of acute confinement followed by analysis of tissue cortisol and plasma cortisol concentrations. Individuals were also sampled for messenger RNA (mRNA) expression of corticotropin-releasing hormone ( CRH), mineralocorticoid receptor ( MR), and glucocorticoid receptor ( GR) in the brain to examine the effects of repeated stress events on constitutive expression of these important stress axis components. Read More

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http://dx.doi.org/10.1177/0023677218793441DOI Listing
August 2018
6 Reads

SPCAL 2018 abstract book.

Authors:

Lab Anim 2018 Aug;52(2_suppl):6-33

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http://dx.doi.org/10.1177/0023677218789822DOI Listing

Committees.

Authors:

Lab Anim 2018 Aug;52(2_suppl):4-5

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http://dx.doi.org/10.1177/0023677218789825DOI Listing

Humanizing the gut microbiota of mice: Opportunities and challenges.

Authors:
Randi Lundberg

Lab Anim 2018 Aug 8:23677218787554. Epub 2018 Aug 8.

Internal Research and Development, Taconic Biosciences, Lille Skensved, Denmark.

Mouse colonized with human fecal microbiota is an interesting model concept with pros and cons like any other model system. The concept provides an ecologically relevant context to study food component and drug metabolism, and is an invaluable tool for phenotype transfer studies to prove the role of the gut microbiota in health and disease. The major drawbacks are the difficulties with transferring certain components of the human microbiota to the recipient mice, and immunological abnormalities observed in these mice. Read More

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http://dx.doi.org/10.1177/0023677218787554DOI Listing

Impact assessment of tail-vein injection in mice using a modified anaesthesia induction chamber versus a common restrainer without anaesthesia.

Lab Anim 2018 Aug 8:23677218786982. Epub 2018 Aug 8.

1 Institute of Laboratory Animal Science, University of Veterinary Medicine Vienna, Austria.

Intravenous (IV) administration in mice is predominantly performed via the lateral tail veins. The technique requires adequate training before it can be used safely and routinely. A novel anaesthesia induction chamber has been developed to simplify the treatment and to facilitate IV injection in mice, particularly for untrained personnel. Read More

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http://dx.doi.org/10.1177/0023677218786982DOI Listing

Guidelines for porcine models of human bacterial infections.

Lab Anim 2018 Aug 8:23677218789444. Epub 2018 Aug 8.

Department of Veterinary and Animal Science, University of Copenhagen, Copenhagen, Denmark.

During the last 10 years the number of porcine models for human bacterial infectious diseases has increased. In the future, this tendency is expected to continue and, therefore, the aim of the present review is to describe guidelines for the development and reporting of these models. The guidelines are based on a review of 122 publications of porcine models for different bacterial infectious diseases in humans. Read More

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http://dx.doi.org/10.1177/0023677218789444DOI Listing
August 2018
1 Read

4D cardiac magnetic resonance imaging, 4D and 2D transthoracic echocardiography: a comparison of in-vivo assessment of ventricular function in rats.

Lab Anim 2018 Aug 6:23677218789971. Epub 2018 Aug 6.

1 Department of Paediatric Cardiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.

Preclinical cardiovascular research is the foundation of our understanding and broad knowledge of heart function and cardiovascular disease. Reliable cardiac imaging modalities are the basis for applicable results. Four-dimensional cardiac magnetic resonance (4D CMR) has been set as the gold standard for in-vivo assessment of ventricular function in rodents. Read More

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http://dx.doi.org/10.1177/0023677218789971DOI Listing
August 2018
11 Reads

Dr Harry Blom.

Lab Anim 2018 Oct 2;52(5):541. Epub 2018 Aug 2.

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http://dx.doi.org/10.1177/0023677218791947DOI Listing
October 2018

Workshop sobre Clasificación de Severidad en Madrid.

Authors:
Elena Hevia

Lab Anim 2018 Aug;52(4):429

SECAL (Sociedad Española para las Ciencias del Animal de Laboratorio), Spain.

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http://dx.doi.org/10.1177/0023677218788799DOI Listing

Achievements of FELASA over the past 40 years.

Authors:

Lab Anim 2018 Aug;52(4):427

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http://dx.doi.org/10.1177/0023677218788957DOI Listing

A rat model of nerve stimulator-guided brachial plexus blockade.

Lab Anim 2018 Jul 26:23677218779608. Epub 2018 Jul 26.

1 Department of Anesthesiology, West China Hospital, Sichuan University, China.

It is important to develop a feasible animal model of regional anesthesia other than sciatic nerve blockade for pharmacokinetic investigations of new local anesthetics or analgesia in upper extremity surgery. Herein, we explored a nerve stimulator (NS)-guided brachial plexus block (BPB) in a rat model. The anatomy of the brachial plexus in rats was delineated in cadavers, and various BPBs were examined. Read More

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http://dx.doi.org/10.1177/0023677218779608DOI Listing
July 2018
18 Reads

The effects of sucrose on urine collection in metabolic cages.

Lab Anim 2018 Jul 25:23677218781674. Epub 2018 Jul 25.

1 Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia.

Representative urine collection that respects the standards of animal welfare is still an issue in experimental nephrology. The commonly used metabolic cages induce stress in rodents. In mice, the volume of collected urine is sometimes insufficient for further analysis. Read More

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http://dx.doi.org/10.1177/0023677218781674DOI Listing
July 2018
10 Reads

FELASA accreditation of education and training courses in laboratory animal science according to the Directive 2010/63/EU.

Lab Anim 2018 Jul 24:23677218788105. Epub 2018 Jul 24.

6 Swedish Centre for Animal Welfare, Swedish University of Agricultural Sciences, Uppsala, Sweden.

This document describes how the Federation of European Laboratory Animal Science Associations (FELASA) accreditation addresses both the Directive 2010/63/EU and the related European Commission guidance document. The four EU Functions and beyond: FELASA accredits courses that fulfil the requirements of Functions A, B, C and D as defined by EU Directive, Article 23, as well as for designated veterinarians and specialists in laboratory animal science. Modularity and mobility: Cohesive courses for Functions and for very specific topics are accredited, but flexibility and mobility are possible: a researcher can start his/her training with one FELASA accredited course and complete other modules with another. Read More

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http://dx.doi.org/10.1177/0023677218788105DOI Listing
July 2018
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