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    13439 results match your criteria Atherosclerosis[Journal]

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    Reliability of oscillometric central blood pressure and central systolic loading in individuals over 50 years: Effects of posture and fasting.
    Atherosclerosis 2017 Dec 27;269:79-85. Epub 2017 Dec 27.
    Department of Sport & Exercise, University of Winchester, UK.
    Background And Aims: The between-day reliability of oscillometric pulse wave analysis has been demonstrated in a young, healthy population but not in an older sample. This study examined the between-day reliability of the SphygmoCor XCEL in individuals over 50 years. As blood pressure is measured in a range of postures and fasting states (supine/seated, fasted/non-fasted), this study also investigated the effect of these variables on central blood pressure and central systolic loading. Read More

    Reduced calcification and osteogenic features in advanced atherosclerotic plaques of mice with macrophage-specific loss of TRPC3.
    Atherosclerosis 2017 Dec 22. Epub 2017 Dec 22.
    Department of Physiology and Pharmacology, Center for Hypertension and Personalized Medicine, University of Toledo College of Medicine and Life Sciences, Health Science Campus, 3000 Transverse Dr., Toledo, OH 43614, USA. Electronic address:
    Background And Aims: Recent in vitro studies have showed that in macrophages, deletion of the non-selective Ca2+-permeable channel TRPC3 impairs expression of the osteogenic protein BMP-2. The pathophysiological relevance of this effect in atherosclerotic plaque calcification remains to be determined.

    Methods: We used Ldlr-/- mice with macrophage-specific loss of TRPC3 (MacTrpc3-/-/Ldlr-/-) to examine the effect of macrophage Trpc3 on plaque calcification and osteogenic features in advanced atherosclerosis. Read More

    Mild hyperbilirubinaemia as an endogenous mitigator of overweight and obesity: Implications for improved metabolic health.
    Atherosclerosis 2017 Dec 14. Epub 2017 Dec 14.
    University of Vienna, Faculty of Life Sciences, Department of Nutritional Sciences, Althanstraße 14 (UZA2), 1090, Vienna, Austria; Research Platform Active Ageing, University of Vienna, Faculty of Life Sciences, Althanstraße 14 (UZA2), 1090, Vienna, Austria. Electronic address:
    Background And Aims: Mild endogenous elevation of unconjugated bilirubin (UCB) as seen in Gilbert's syndrome (GS), might mitigate cardiovascular disease (CVD) risk factors including overweight/obesity. This study aimed to determine whether hyperbilirubinaemia is linked to improved anthropometric data and lipid profile.

    Methods: Our study considered GS and age-/gender-matched healthy controls (n = 248). Read More

    Plasma levels of n-3 fatty acids and risk of coronary heart disease among Japanese: The Japan Public Health Center-based (JPHC) study.
    Atherosclerosis 2017 Dec 8. Epub 2017 Dec 8.
    Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
    Background And Aims: Higher intake of fish or n-3 polyunsaturated fatty acids (PUFAs) has been associated with reduced risk of coronary heart disease (CHD). However, it is unclear whether increased blood levels of n-3 PUFAs are associated with reduced risk of CHD in the Japanese population.

    Methods: The relationship between circulating levels of n-3 PUFAs (eicosapentaenoic acid + docosapentaenoic acid + docosahexaenoic acid) and risk of CHD was examined in a nested case-control study among participants in the Japan Public Health Center (JPHC)-based Study Cohort. Read More

    IgA antibodies to phosphocholine associate with long-term cardiovascular disease risk.
    Atherosclerosis 2017 Dec 8. Epub 2017 Dec 8.
    Medical Microbiology and Immunology, Research Unit of Biomedicine, University of Oulu, POB 5000, FI-90014, Finland; Medical Research Center and Nordlab Oulu, University Hospital, University of Oulu, POB 5000, Oulu FI-90014, Finland. Electronic address:
    Background And Aims: Antibodies to phosphocholine and oxidized LDL (oxLDL) are proposed to modify progression of atherosclerosis. We investigated the prognostic value of antibodies to phosphocholine (PCho), Streptococcus pneumoniae cell wall polysaccharide (CWPS) and oxLDL in defining long-term CVD survival.

    Methods: CVD incidence was followed for 18 years and analyzed with baseline plasma IgM, IgG and IgA antibody levels to PCho, CWPS and oxLDL in 1044 subjects of Oulu Project Elucidating Risk of Atherosclerosis study (OPERA). Read More

    Upregulation of miR-221 and -222 in response to increased extracellular signal-regulated kinases 1/2 activity exacerbates neointimal hyperplasia in diabetes mellitus.
    Atherosclerosis 2017 Dec 9;269:71-78. Epub 2017 Dec 9.
    Department of Physiology and the Section of Cardiology, Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA; Laboratory of Molecular Cardiology, Ochsner Clinic Foundation, New Orleans, LA, USA. Electronic address:
    Background And Aims: Diabetes is associated with accelerated arterial intimal thickening that contributes to the increased cardiovascular disease seen in this population. In healthy arteries, intimal thickening is inhibited by elevated levels of the cyclin-dependent kinase inhibitor, p27Kip1, and intimal thickening is promoted by activation of the mammalian Target of Rapamycin to promote degradation of p27Kip1 protein. Recently, we reported that two microRNAs, miR-221 and -222, which promote intimal thickening via down-regulation of mRNA encoding p27Kip1, are elevated in the arteries of diabetic patients. Read More

    Genetic polymorphisms offer insight into the causal role of microRNA in coronary artery disease.
    Atherosclerosis 2017 Dec 15;269:63-70. Epub 2017 Dec 15.
    CNR Institute of Clinical Physiology, Pisa, Italy.
    There is growing interest in the potential of circulating microRNAs (miRNAs), a class of small and noncoding RNA molecules, as diagnostic and/or prognostic biomarkers in coronary artery disease (CAD). Despite this promising role, there are still widespread inconsistencies among studies, and important obstacles must be overcome before miRNAs can enter clinical practice. The study of single nucleotide polymorphisms (SNPs) in the miRNA regulatory network could help shed light on the causality of associations as well as validate the value of cardiovascular miRNAs. Read More

    Predictors of carotid plaque progression over a 4-year follow-up in the Reykjavik REFINE-study.
    Atherosclerosis 2017 Dec 6;269:57-62. Epub 2017 Dec 6.
    Icelandic Heart Association, Kopavogur, Iceland; University of Iceland, Reykjavik, Iceland. Electronic address:
    Background And Aims: Carotid plaque is an arterial marker suggested as a surrogate end point for cardiovascular disease. The aim of this study was to examine the association of risk factors at visit 1 with plaque formation and progression of total plaque area (TPA) during follow-up.

    Methods: We examined 1894 participants (50-69 years of age) in the population-based REFINE (Risk Evaluation For INfarct Estimates)-Reykjavik study. Read More

    Mediterranean diet improves endothelial function in patients with diabetes and prediabetes: A report from the CORDIOPREV study.
    Atherosclerosis 2017 Dec 8;269:50-56. Epub 2017 Dec 8.
    Lipid and Atherosclerosis Unit, Department of Internal Medicine / IMIBIC/Reina Sofia University Hospital/University of Cordoba, Spain; CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Spain.
    Background And Aims: Endothelial dysfunction (ED) plays a key role in the development of atherosclerotic cardiovascular disease (ASCVD). Likewise, type 2 diabetes (T2D) is a major CVD risk factor. Therefore, our objective was to explore whether long-term consumption of a Mediterranean diet (MedDiet) rich in olive oil or a low-fat diet (LF diet) was associated with an improvement in ED and whether the potential benefits were similar in patients with or without T2D in the CORDIOPREV clinical trial (NCT00924937). Read More

    Genetic variants in PPARGC1B and CNTN4 are associated with thromboxane A2 formation and with cardiovascular event free survival in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT).
    Atherosclerosis 2017 Dec 8;269:42-49. Epub 2017 Dec 8.
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, RCSI, Dublin, Ireland.
    Background And Aims: Elevated urinary 11-dehydro thromboxane B2 (TxB2), a measure of thromboxane A2 formation in vivo, predicts future atherothrombotic events. To further understand this relationship, the genetic determinants of 11-dehydro TxB2 and their associations with cardiovascular morbidity were investigated in this study.

    Methods: Genome-wide and targeted genetic association studies of urinary 11-dehydro TxB2 were conducted in 806 Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) participants. Read More

    Combined blockade of renin-angiotensin-aldosterone system reduced all-cause but not cardiovascular mortality in dialysis patients: A mediation analysis and systematic review.
    Atherosclerosis 2017 Dec 6;269:35-41. Epub 2017 Dec 6.
    Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Cardiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120 China; Laboratory of RNA and Major Diseases of Brain and Heart, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120 China. Electronic address:
    Background And Aims: Full blockade of renin-angiotensin-aldosterone system (RAAS) is believed to decrease morbidity and mortality of patients with chronic kidney disease. In non-dialysis patients, combined RAAS blockade with two different RAAS blockers causes more adverse events without improving survival, but its role in maintenance dialysis patients is still unclear. We conducted a systematic review and mediation analysis to investigate the efficacy and safety of combined RAAS blockade in dialysis patients. Read More

    High levels of lipoprotein (a) and premature acute coronary syndrome.
    Atherosclerosis 2017 Dec 7;269:29-34. Epub 2017 Dec 7.
    Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece; Faculty of Health, University of Canberra, Australia; School of Allied Health, College of Science, Health and Engineering, LA TROBE University, Australia.
    Background And Aims: High levels of lipoprotein(a) [Lp(a)] are associated with increased risk of acute coronary syndrome (ACS). We explored whether Lp(a) exhibits a stronger association with premature ACS.

    Methods: A case-control study was conducted; 1457 patients with a history of ACS (54. Read More

    Persistent socioeconomic disparities in cardiovascular risk factors and health in the United States: Medical Expenditure Panel Survey 2002-2013.
    Atherosclerosis 2017 Dec 8. Epub 2017 Dec 8.
    Center for Healthcare Advancement and Outcomes, Baptist Health South Florida, Miami, FL, USA; The Johns Hopkins Ciccarone Center for Prevention of Cardiovascular Disease, Baltimore, MD, USA; Department of Epidemiology, Robert Stempel College of Public Health, Florida International University, Miami, FL, USA; Department of Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA; Miami Cardiac and Vascular Institute, Baptist Health South Florida, Miami, FL, USA. Electronic address:
    Background And Aims: Socioeconomic status (SES) has been linked to worse cardiovascular risk factor (CRF) profiles and higher rates of cardiovascular disease (CVD), with an especially high burden of disease for low-income groups. We aimed to describe the trends in prevalence of CRFs among US adults by SES from 2002 to 2013.

    Methods: Data from the Medical Expenditure Panel Survey was analyzed. Read More

    Morphometric measurements of extracranial and intracranial atherosclerotic disease: A population-based autopsy study.
    Atherosclerosis 2017 Dec 9. Epub 2017 Dec 9.
    Department of Pathology, University of São Paulo Medical School, Brazil.
    Background And Aims: Intracranial (IAD) and extracranial atherosclerotic diseases (EAD) have been mostly investigated using imaging methods. Autopsy studies allow for a direct and complete evaluation of the atherosclerotic disease. We aimed to investigate the frequency of IAD and EAD, their association, and related risk profiles in a large cross-sectional autopsy study. Read More

    Renal function is associated with 1-month and 1-year mortality in patients with ischemic stroke.
    Atherosclerosis 2017 Dec 11. Epub 2017 Dec 11.
    Department of Neurology, China Medical University Hospital, Taichung, Taiwan.
    Background And Aims: Renal dysfunction is a potent risk factor for cardiovascular diseases, including stroke. This study aimed to evaluate the impact of admission estimated glomerular filtration rate (eGFR) levels on short-term (1-month) and long-term (1-year) mortality in patients with acute ischemic stroke.

    Methods: From the Taiwan Stroke Registry data, we classified ischemic stroke patients, identified from April 2006 to December 2015, into 5 groups by eGFR at admission: ≥ 90, 60-89, 30-59, 15-29, and <15 mL/min/1. Read More

    PCSK9 inhibitors in clinical practice: Delivering on the promise?
    Atherosclerosis 2017 Dec 1. Epub 2017 Dec 1.
    Department of Vascular Medicine, Academic Medical Center, 1100DD Amsterdam, The Netherlands. Electronic address:
    Background And Aims: In clinical trials, protein convertase subtilisin/kexin type 9 (PCSK9) inhibitors robustly lowered LDL-cholesterol (LDL-c) and had a favorable tolerability and safety profile. Based on these findings, PCSK9 inhibitors are incorporated in updates of clinical treatment guidelines. However, trial results do not necessarily predict the effectiveness under real-world conditions. Read More

    Metabolic phenotyping of human atherosclerotic plaques: Metabolic alterations and their biological relevance in plaque-containing aorta.
    Atherosclerosis 2017 Dec 6;269:21-28. Epub 2017 Dec 6.
    Integrated Metabolomics Research Group, Western Seoul Center, Korea Basic Science Institute, Seoul 120-140, Republic of Korea; Department of Life Science, Ewha Womans University, Seoul, Republic of Korea. Electronic address:
    Background And Aims: Atherosclerosis is a chronic inflammatory disease characterized by thickening of the arterial wall. However, a limited number of studies have been conducted on metabolic profiling of human aortic tissue.

    Methods: We applied liquid chromatography/mass spectrometry to perform global and targeted profiling of plaque-containing aortic tissue. Read More

    Higher low-density lipoprotein cholesterol levels are associated with decreased mortality in patients with intracerebral hemorrhage.
    Atherosclerosis 2017 Dec 6;269:14-20. Epub 2017 Dec 6.
    Second Department of Neurology, School of Medicine, National & Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece; Department of Neurology, University of Tennessee Health Science Center, Memphis, TN, USA.
    Background And Aims: The relationship between lipoprotein levels, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and clinical outcome after intracerebral hemorrhage (ICH) remains controversial. We sought to evaluate the association of lipoprotein cholesterol levels and statin dosage with clinical and neuroimaging outcomes in patients with ICH.

    Methods: Data on consecutive patients hospitalized with spontaneous acute ICH was prospectively collected over a 5-year period and retrospectively analyzed. Read More

    Coronary calcification as a mechanism of plaque/media shrinkage in vessels treated with bioresorbable vascular scaffold: A multimodality intracoronary imaging study.
    Atherosclerosis 2017 Dec 2;269:6-13. Epub 2017 Dec 2.
    International Centre for Circulatory Health, Imperial College, London, United Kingdom. Electronic address:
    Background And Aims: Whether coronary calcification is correlated with plaque/media shrinkage (PS) remains unclear. The aim of this study was to assess the relationship between the calcification process and PS, combining serial optical coherence tomography (OCT) and intravascular ultrasound (IVUS) in vessels treated with bioresorbable vascular scaffolds (BVS).

    Methods: In 15 patients (16 vessels), OCT and IVUS images were matched using anatomic landmarks at post-procedure and five years. Read More

    Autosomal recessive hypercholesterolemia in Spain.
    Atherosclerosis 2017 Dec 6;269:1-5. Epub 2017 Dec 6.
    Unidad de Medicina Vascular y Metabolica, Unidad de Investigación en Lipidos y Arterioesclerosis, Hospital Universitario "Sant Joan", Universitat Rovira i Virgili, IISPV, CIBERDEM, Reus, Madrid, Spain.
    Background And Aims: Autosomal recessive hypercholesterolemia (ARH) is a very rare disease, caused by mutations in LDL protein receptor adaptor 1 (LDLRAP1). It is characterized by high levels of low-density lipoprotein cholesterol (LDL-C) and increased risk of premature cardiovascular disease. We aimed to characterize ARH in Spain. Read More

    Total cholesterol and stroke mortality in middle-aged and elderly adults: A prospective cohort study.
    Atherosclerosis 2017 Dec 6. Epub 2017 Dec 6.
    Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
    Background And Aims: The association between cholesterol and stroke has been inconsistent. This study aimed to examine the association between total cholesterol (TC) and mortality from total stroke and stroke subtypes.

    Methods: 503,340 Korean adults aged 40-80 years without a history of heart disease or stroke participated in routine health examinations in 2002 and 2003, and were followed up until 2013. Read More

    Immunologic burden links periodontitis to acute coronary syndrome.
    Atherosclerosis 2018 Jan 6;268:177-184. Epub 2017 Dec 6.
    Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Haartmaninkatu 8, 00290, Helsinki, Finland.
    Background And Aims: Periodontitis, a common polymicrobial inflammatory disease in the tooth supporting tissues, is a risk factor for coronary artery disease. One of the proposed underlying mechanisms is the systemic immune response to periodontal infection. We studied how serum antibodies against seven periodontal pathogens and their subgingival levels associate with each other, periodontitis, and coronary artery disease. Read More

    TM6SF2: A novel target for plasma lipid regulation.
    Atherosclerosis 2018 Jan 1;268:170-176. Epub 2017 Dec 1.
    Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan 421001, China; Department of Biochemistry and Molecular Biology, The Libin Cardiovascular Institute of Alberta, The University of Calgary, Health Sciences Center, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada. Electronic address:
    Transmembrane 6 superfamily 2 (TM6SF2), a gene identified at the locus 19p12, has been recognized to regulate plasma lipids. Here, we provide an overview of the roles of TM6SF2 as a novel target for plasma lipid regulation. We first review the association of TM6SF2 variant with plasma lipid traits, cardiovascular disease (CVD) and non-alcoholic fatty liver disease (NAFLD). Read More

    Impact of alcohol drinking on acetylcholine-induced coronary artery spasm in Korean populations.
    Atherosclerosis 2018 Jan 8;268:163-169. Epub 2017 Dec 8.
    Cardiovascular Center, Korea University Guro Hospital, Seoul, South Korea. Electronic address:
    Background And Aims: Generally, immoderate alcohol consumption is associated with variant angina and accepted as one of the risk factors for coronary artery spasm (CAS), but evidence is lacking in this regard. The aim of this study is to evaluate the impact of alcohol consumption and drinking pattern on CAS by acetylcholine (ACH) provocation test and long-term clinical outcomes.

    Methods: A total of 5491 patients with typical or atypical chest pain, without significant coronary artery disease, who underwent intracoronary ACH provocation test, were enrolled prospectively, and retrospectively analyzed in this study. Read More

    Reliability of oscillometric central blood pressure responses to lower limb resistance exercise.
    Atherosclerosis 2018 Jan 5;268:157-162. Epub 2017 Dec 5.
    Department of Sport and Exercise, University of North Carolina, Chapel Hill, USA.
    Background And Aims: Although it is well known that resistance training (RT) is beneficial for patients suffering from a variety of cardiovascular diseases, it remains underutilized as a rehabilitation tool as there is no reliable way to monitor the additional stress placed on the central organs. The current study aimed to determine between-day reliability of central haemodynamic indices using oscillometric pulse wave analysis (PWA) during progressive sub-maximal RT.

    Methods: Nineteen healthy young males were tested on 3 different mornings in a fasted state. Read More

    Systemic mastocytosis associates with cardiovascular events despite lower plasma lipid levels.
    Atherosclerosis 2018 Jan 22;268:152-156. Epub 2017 Dec 22.
    Department of Internal Medicine, Division Vascular Medicine, Erasmus MC, Rotterdam, The Netherlands. Electronic address:
    Background And Aims: Mast cells have been implicated in the development and progression of atherosclerosis in animal models and human autopsy studies. However, it is unknown whether long-term exposure to excess of mast cells is associated with cardiovascular disease (CVD) in humans. Our objective was to compare the prevalence of CVD and cardiovascular risk factors in patients with systemic mastocytosis (SM) and controls. Read More

    Associations between vitamin D status and atherosclerosis among Inuit in Greenland.
    Atherosclerosis 2018 Jan 1;268:145-151. Epub 2017 Dec 1.
    National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.
    Background And Aims: Low levels of vitamin D are suspected to be a risk factor for cardiovascular disease and atherosclerosis. The aim of this study was to assess the prevalence of subclinical atherosclerosis among Inuit in Greenland, and to evaluate the association with vitamin D status. We hypothesized that low vitamin D status could be associated with higher carotid intima-media thickness (IMT) as a marker of atherosclerosis. Read More

    Relationship between thrombus age in aspirated coronary material and mid-term major adverse cardiac and cerebrovascular events in patients with acute myocardial infarction.
    Atherosclerosis 2018 Jan 5;268:138-144. Epub 2017 Dec 5.
    Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
    Background And Aims: Recent studies have shown that coronary thrombus histopathology is associated with impaired myocardial reperfusion and poor clinical outcome in patients with acute myocardial infarction (AMI). We sought to investigate the age of thrombi aspirated during percutaneous coronary intervention (PCI) in patients with AMI and evaluate the relationship between histopathologic findings and major adverse cardiac and cerebrovascular events (MACCEs) defined as all-cause death, stroke, or myocardial infarction within 6 months of PCI.

    Methods: In this prospective 2-center observational study, coronary material was obtained during PCI from 305 patients with AMI within 24 h of symptom onset. Read More

    Additional prognostic value of brachial-ankle pulse wave velocity to coronary computed tomography angiography in patients with suspected coronary artery disease.
    Atherosclerosis 2018 Jan 1;268:127-137. Epub 2017 Dec 1.
    Division of Cardiology, Department of Internal Medicine, Boramae Medical Center, Seoul National University College of Medicine, Seoul, Republic of Korea.
    Background And Aims: Increased arterial stiffness is associated with a higher risk of future cardiovascular events. We aimed to investigate whether information about arterial stiffness provides additional prognostic value to coronary computed tomography angiography (CCTA) findings.

    Methods: A total of 523 consecutive patients (mean age, 58. Read More

    Berberine treatment increases Akkermansia in the gut and improves high-fat diet-induced atherosclerosis in Apoe-/- mice.
    Atherosclerosis 2018 Jan 24;268:117-126. Epub 2017 Nov 24.
    Department of Gastroenterology, Zhongshan Hospital of Fudan University, Shanghai, PR China; Shanghai Institute of Liver Diseases, Key Laboratory of Medical Molecule Virology, Ministry of Education and Health, Shanghai, PR China. Electronic address:
    Background And Aims: Gut microbiota plays a major role in metabolic disorders. Berberine is used to treat obesity, diabetes and atherosclerosis. The mechanism underlying the role of berberine in modulating metabolic disorders is not fully clear because berberine has poor oral bioavailability. Read More

    Aortic atherosclerosis is a key modulator of the prognostic value of postural blood pressure changes.
    Atherosclerosis 2018 Jan 26;268:108-116. Epub 2017 Nov 26.
    Cardiology Department, European Society of Hypertension Excellence Center, Hôpital de la Croix-Rousse et Hôpital Lyon Sud, Hospices Civils de Lyon, F-69004, Lyon, France; Université de Lyon, CREATIS, CNRS UMR5220, INSERM U1044, INSA-Lyon, Université Claude Bernard Lyon 1, Hospices Civils de Lyon, France.
    Background And Aims: Orthostatic blood pressure decrease or increase has been related to cardiovascular events in hypertensive patients. Large blood pressure changes after orthostatic stress are associated with autonomic and neurohormonal abnormalities; aortic atherosclerosis (ATS) may also play a role.

    Methods: We investigated the interaction of ATS on the prognostic value of postural blood pressure changes. Read More

    Utilization of lipid-modifying therapy and low-density lipoprotein cholesterol goal attainment in patients at high and very-high cardiovascular risk: Real-world evidence from Germany.
    Atherosclerosis 2018 Jan 20;268:99-107. Epub 2017 Nov 20.
    IMS Health, London, UK.
    Background And Aims: Elevated low-density lipoprotein cholesterol (LDL-C) is a causal risk factor for cardiovascular (CV) events. European guidelines recommend reducing LDL-C as the primary lipid target to reduce CV risk, using lifestyle modifications and lipid-lowering therapy (LLT). Many European patients do not achieve guideline-recommended LDL-C levels. Read More

    Brachial artery diameter as a marker for cardiovascular risk assessment: FMD-J study.
    Atherosclerosis 2018 Jan 22;268:92-98. Epub 2017 Nov 22.
    Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan; Division of Regeneration and Medicine, Hiroshima University Hospital, Hiroshima, Japan. Electronic address:
    Background And Aims: Baseline brachial artery (BBA) diameter has been reported to be a potential confounding factor of flow-mediated vasodilation (FMD). The purpose of this study was to evaluate the relationships between BBA diameter and cardiovascular risk factors and compare the diagnostic accuracy of BBA diameter in subjects without cardiovascular risk factors and patients with cardiovascular disease (CVD) with that of FMD.

    Methods: We measured BBA diameter and FMD in 5695 male subjects. Read More

    Association of alcohol consumption and aortic calcification in healthy men aged 40-49 years for the ERA JUMP Study.
    Atherosclerosis 2018 Jan 21;268:84-91. Epub 2017 Nov 21.
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA, USA.
    Background And Aims: Several studies have reported a significant inverse association of light to moderate alcohol consumption with coronary heart disease (CHD). However, studies assessing the relationship between alcohol consumption and atherosclerosis have reported inconsistent results. The current study was conducted to determine the relationship between alcohol consumption and aortic calcification. Read More

    Novel combined index of cardiometabolic risk related to periarterial fat improves the clinical prediction for coronary artery disease complexity.
    Atherosclerosis 2018 Jan 15;268:76-83. Epub 2017 Sep 15.
    Department of Cardiology, School of Health Sciences, Medical University of Silesia, Katowice, Poland.
    Background And Aims: Cardiovascular (CV) risk assessment based on conventional risk factors has a limited performance in the prediction of obstructive coronary artery disease (CAD). Therefore, our aim was to provide a complete assessment on the associations between single or combined cardiovascular ultrasound indexes and the complexity of CAD in high and very-high risk patients.

    Methods: Two hundred fifteen patients scheduled for elective coronary angiography were enrolled in the study (F/M: 80/135 pts; age: 61. Read More

    Role of angiopoietin-like 3 (ANGPTL3) in regulating plasma level of low-density lipoprotein cholesterol.
    Atherosclerosis 2018 Jan 21;268:196-206. Epub 2017 Sep 21.
    Center for Genomic Medicine and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:
    Background And Aims: Angiopoietin-like 3 (ANGPTL3) has emerged as a key regulator of lipoprotein metabolism in humans. Homozygous loss of ANGPTL3 function causes familial combined hypolipidemia characterized by low plasma levels of triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C). While known effects of ANGPTL3 in inhibiting lipoprotein lipase and endothelial lipase contribute to the low TG and HDL-C, respectively, the basis of low LDL-C remains unclear. Read More

    Elevated circulating TGF-β is not the cause of increased atherosclerosis development in biglycan deficient mice.
    Atherosclerosis 2018 Jan 10;268:68-75. Epub 2017 Nov 10.
    Department of Veterans Affairs, Lexington, KY, USA; Division of Endocrinology and Molecular Medicine, Lexington, KY, USA; Barnstable Brown Diabetes Center, University of Kentucky, Lexington, KY, USA. Electronic address:
    Background And Aims: Vascular biglycan contributes to atherosclerosis development and increased biglycan expression correlates with increased atherosclerosis. However, mice deficient in biglycan have either no reduction in atherosclerosis or an unexpected increase in atherosclerosis. Biglycan deficient mice have systemically elevated TGF-β, likely due to lack of sequestration of TGF-β in the extracellular matrix. Read More

    Lipoprotein(a) and abdominal aortic aneurysm risk: The Atherosclerosis Risk in Communities study.
    Atherosclerosis 2018 Jan 26;268:63-67. Epub 2017 Nov 26.
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
    Background And Aims: No prospective study has investigated whether elevated lipoprotein(a) concentrations are associated with an increased risk of abdominal aortic aneurysm (AAA). We aimed to prospectively investigate this association.

    Methods: In 1987-1989, the Atherosclerosis Risk in Communities study measured plasma lipoprotein(a) in 13,683 participants aged 45-64 years, without a history of AAA surgery. Read More

    Leisure-time physical activity across adulthood and biomarkers of cardiovascular disease at age 60-64: A prospective cohort study.
    Atherosclerosis 2017 Nov 20. Epub 2017 Nov 20.
    MRC Unit for Lifelong Health and Ageing at UCL, London, UK.
    Background And Aims: This study examined associations between leisure-time physical activity (LTPA) across adulthood (from age 36) and cardiovascular disease (CVD) biomarkers at age 60-64.

    Methods: LTPA was reported by study participants from the MRC National Survey of Health and Development at ages 36, 43, 53 and 60-64 (n = 1754) and categorised as inactive, moderately active (1-4/month) or most active (5+/month) at each age. Linear regression was used to examine associations between a cumulative adulthood LTPA score (range = 0-8), and change in LTPA between ages 36 and 60-64 (i. Read More

    Thrombogenicity and central pulse pressure to enhance prediction of ischemic event occurrence in patients with established coronary artery disease: The MAGMA-ischemia score.
    Atherosclerosis 2018 Jan 20;268:55-62. Epub 2017 Nov 20.
    Inova Center for Thrombosis Research and Drug Development, Inova Heart and Vascular Institute, Fairfax, VA, USA. Electronic address:
    Background And Aims: Conventional cardiovascular risk estimators based on clinical demographics have limited prediction of coronary events. Markers for thrombogenicity and vascular function have not been explored in risk estimation of high-risk patients with coronary artery disease. We aimed to develop a clinical and biomarker score to predict 3-year adverse cardiovascular events. Read More

    Arterial inflammation measured by 18F-FDG-PET-CT to predict coronary events in older subjects.
    Atherosclerosis 2018 Jan 21;268:49-54. Epub 2017 Nov 21.
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
    Background And Aims: Although 18F-fluorodeoxyglucose (FDG) uptake has emerged as a sensitive and reliable marker of atherosclerotic inflammation, its additive predictive value for future coronary disease in older subjects is unknown. The aim of this study was to test the prognostic value of aortic inflammation detected via FDG-positron emission tomography (PET)-computed tomography (CT) in older subjects.

    Methods: We retrospectively utilized the records of 309 subjects aged over 65 years, without a history of coronary artery disease, who underwent 18F-FDG-PET-CT mostly due to the clinical suspicion of cancer, but eventually turned out to be cancer-free. Read More

    IgM antibodies against phosphorylcholine promote polarization of T regulatory cells from patients with atherosclerotic plaques, systemic lupus erythematosus and healthy donors.
    Atherosclerosis 2018 Jan 16;268:36-48. Epub 2017 Nov 16.
    Unit of Immunology and Chronic Disease, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Division of Emergency Medicine, Karolinska University Hospital, Sweden. Electronic address:
    Background And Aims: IgM antibodies against phosphorylcholine (anti-PC) are negatively associated with atherosclerosis, cardiovascular disease (CVD) and systemic lupus erythematosus (SLE), where the risk of CVD and atherosclerosis is high. We here study the effects of IgM anti-PC immune regulation.

    Methods: Mononuclear leukocytes were isolated from peripheral blood (PBMC) obtained from healthy blood donors, six SLE patients with age- and sex-matched controls, and symptom-giving human atherosclerotic plaques. Read More

    Serum amyloid A3 is pro-atherogenic.
    Atherosclerosis 2018 Jan 17;268:32-35. Epub 2017 Nov 17.
    Department of Veterans Affairs, Lexington, KY 40502, USA; Department of Internal Medicine, University of Kentucky, Lexington, KY, 40536, USA; Barnstable Brown Diabetes Center, University of Kentucky, Lexington, KY, 40536, USA; Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY, 40536, USA. Electronic address:
    Background And Aims: Serum amyloid A (SAA) predicts cardiovascular events. Overexpression of SAA increases atherosclerosis development; however, deficiency of two of the murine acute phase isoforms, SAA1.1 and SAA2. Read More

    Subclinical cerebrovascular disease in NAFLD without overt risk factors for atherosclerosis.
    Atherosclerosis 2018 Jan 16;268:27-31. Epub 2017 Nov 16.
    Department of Internal Medicine, IRCCS Ca' Granda Ospedale Maggiore Policlinico Foundation, University of Milan, Milan, Italy.
    Background And Aims: Non-alcoholic fatty liver disease is recognized not only as part of the metabolic syndrome but also as an independent predictor of cardiovascular disease.

    Methods: In this study, NMR spectroscopy method, together with perfusion techniques, was used to detect subclinical brain vascular damage in subjects with NAFLD without overt atherosclerosis risk factors (i.e. Read More

    Reply to: "Prognostic value of lipoprotein-associated phospholipase A2 mass for all-cause mortality and vascular events within one year after acute ischemic stroke: Methodological issues".
    Atherosclerosis 2018 Jan 21;268:233-234. Epub 2017 Nov 21.
    Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, Jiangsu, China; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA. Electronic address:

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