13,883 results match your criteria Atherosclerosis[Journal]


An aortic calcification in a seventeenth-century autopsy report: The case of Cardinal Camillo Melzi.

Atherosclerosis 2018 Nov 27. Epub 2018 Nov 27.

School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.

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November 2018

Atherosclerosis-associated differentially methylated regions can reflect the disease phenotype and are often at enhancers.

Atherosclerosis 2018 Nov 27;280:183-191. Epub 2018 Nov 27.

Tulane Cancer Center, Tulane University Health Sciences Center, LA, 70112, USA; Center for Bioinformatics and Genomics, Tulane University Health Sciences Center, USA; Hayward Genetics Center, Tulane University Health Sciences Center, New Orleans, LA, 70112, USA. Electronic address:

Background And Aims: Atherosclerosis is a widespread and complicated disease involving phenotypic modulation and transdifferentiation of vascular smooth muscle cells (SMCs), the predominant cells in aorta, as well as changes in endothelial cells and infiltrating monocytes. Alterations in DNA methylation are likely to play central roles in these phenotypic changes, just as they do in normal differentiation and cancer.

Methods: We examined genome-wide DNA methylation changes in atherosclerotic aorta using more stringent criteria for differentially methylated regions (DMRs) than in previous studies and compared these DMRs to tissue-specific epigenetic features. Read More

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November 2018

Trends in statin prescription prevalence, initiation, and dosing: Hong Kong, 2004-2015.

Atherosclerosis 2018 Nov 10;280:174-182. Epub 2018 Nov 10.

Division of Cardiology, Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region.

Background And Aims: Clinical practice guidelines recommend specific statin doses for the primary and secondary prevention of cardiovascular disease. Little is known about how statin utilization and dosing have evolved over time in Hong Kong. The aim of this study was to describe trends in statin prevalence, initiation, and dosing from 2004 to 2015. Read More

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November 2018

Impact of renin-angiotensin system inhibitors on long-term clinical outcomes in patients with acute myocardial infarction treated with successful percutaneous coronary intervention with drug-eluting stents: Comparison between STEMI and NSTEMI.

Atherosclerosis 2018 Nov 27;280:166-173. Epub 2018 Nov 27.

Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, South Korea.

Background And Aims: We compared the clinical impact of renin-angiotensin system inhibitors (RASI) on long-term clinical outcomes between ST-segment elevation (STEMI) and non-ST-segment elevation myocardial infarction (NSTEMI) after successful percutaneous coronary intervention (PCI) with drug eluting stents (DES) because of the paucity of published data.

Methods: A total of 24,960 acute myocardial infarction (AMI) patients who underwent PCI with DES and were prescribed the RASI were enrolled and divided into two groups, the STEMI group (n = 14,061) and the NSTEMI group (n = 10,899). The clinical endpoint was the occurrence of major adverse cardiac events (MACE) defined as all-cause death, cardiac death (CD), recurrent myocardial infarction (re-MI), total coronary revascularization (target lesion revascularization [TLR], target vessel revascularization [TVR], non-TVR) during 2 years. Read More

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November 2018
1 Read
3.994 Impact Factor

The relationship between endothelial function and aortic valve calcification: Multi-Ethnic Study of Atherosclerosis.

Atherosclerosis 2018 Nov 28;280:155-165. Epub 2018 Nov 28.

Harbor UCLA Cardiology, 1000 W. Carson St, Torrance, CA, 90509, USA.

Background And Aims: Aortic valve calcification (AVC) may be associated with atherogenic processes arising from endothelial dysfunction (ED). Limited data is available about the relationship between ED, defined by flow mediated dilation (FMD%) and biomarkers, and the prevalence and progression of AVC in a multiethnic population.

Methods: A sample of 3475 individuals from the Multi-Ethnic Study of Atherosclerosis (MESA), with both initial and repeat CT scans at a mean of 2. Read More

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November 2018

Increased burden of coronary artery calcium from elevated blood pressure in low-risk young adults.

Atherosclerosis 2018 Dec 1. Epub 2018 Dec 1.

Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Department of Clinical Research Design & Evaluation, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea. Electronic address:

Background And Aims: The relationship between blood pressure (BP) levels given in the new hypertension guidelines by the American College of Cardiology and the American Heart Association (ACC/AHA) and subclinical coronary atherosclerosis in low-risk young adults is unknown. We evaluated the association between the new BP categories and coronary artery calcium (CAC) in low-risk, young and middle-aged adults.

Methods: We performed a cross-sectional study of 96,166 Koreans who underwent a health examination including cardiac tomography estimation of CAC scores in 2012-2017. Read More

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December 2018

Stroke risk and outcomes in epilepsy patients: Two retrospective cohort studies based on National Health Insurance in Taiwan.

Atherosclerosis 2018 Nov 23;280:147-154. Epub 2018 Nov 23.

Department of Anesthesiology, Shuan Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Department of Anesthesiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Anesthesiology, Taipei Medical University Hospital, Taipei, Taiwan; Health Policy Research Center, Taipei Medical University Hospital, Taipei, Taiwan; School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan. Electronic address:

Background And Aims: The risk of stroke in epileptic patients and the impact of epilepsy history on stroke patients' outcome have not been studied completely. Our purpose is to evaluate whether patients with epilepsy have increased risk of stroke or post-stroke mortality.

Methods: In Study I, we conducted a retrospective cohort study of 6746 patients with newly diagnosed epilepsy and 26,984 persons without epilepsy between 2000 and 2008, in the database of National Health Insurance in Taiwan. Read More

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November 2018
1 Read

Serum gut microbe-dependent trimethylamine N-oxide improves the prediction of future cardiovascular disease in a community-based general population.

Atherosclerosis 2018 Nov 8;280:126-131. Epub 2018 Nov 8.

Department of Cardiology, Shengjing Hospital of China Medical University, Shenyang 110004, PR China. Electronic address:

Background And Aims: Recent studies have shown that trimethylamine N-oxide (TMAO) is a risk factor for cardiovascular disease (CVD) in different clinical settings, but few studies confirmed the association in a community-based general population.

Methods: This is a nested case-control study from a prospective cohort design. A total of 86 newly diagnosed CVD cases with a median follow-up period of 4. Read More

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November 2018

TPO-Ab plays a role in arterial remodeling in patients with intracranial stenosis.

Atherosclerosis 2018 Nov 27;280:140-146. Epub 2018 Nov 27.

Department of Neurology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China. Electronic address:

Background And Aims: Intracranial stenosis (ICS), the common cause of ischemic stroke worldwide, is associated with a high risk of recurrent stroke. We aimed to investigate the relationship between arterial remodeling and antithyroid peroxidase-antibody (TPO-Ab) level in ICS and the effect of TPO-Ab level on the migration of vascular smooth muscle cells (VSMCs).

Methods: We analyzed data of mild-to-severe ICS patients with normal thyroid function who underwent high-resolution magnetic resonance imaging in our center. Read More

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November 2018
2 Reads

Disruption of a CD1d-mediated interaction between mast cells and NKT cells aggravates atherosclerosis.

Atherosclerosis 2018 Nov 14;280:132-139. Epub 2018 Nov 14.

Division of BioTherapeutics, LACDR, Leiden University, NL, the Netherlands.

Background And Aims: The development of atherosclerosis is tightly regulated by the innate and adaptive immune system. Communication between these two compartments occurs, among others, upon presentation of lipid antigens to the NKT cell population by CD1d-expressing antigen-presenting cells. Recent evidence states that also mast cells express CD1d and can directly communicate with NKT cells. Read More

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November 2018
7 Reads

The important role of apolipoprotein A-II in ezetimibe driven reduction of high cholesterol diet-induced atherosclerosis.

Atherosclerosis 2018 Nov 16;280:99-108. Epub 2018 Nov 16.

Department of Pathophysiology, Key Lab for Shock and Microcirculation Research of Guangdong, Southern Medical University, Guangzhou, 510515, PR China. Electronic address:

Background And Aims: It has been well established that ezetimibe blocks cholesterol absorption to prevent the negative effects of a high-fat diet in atherosclerosis. However, the exact mechanism is unknown. Here we use a transgenic zebrafish, which expresses different fluorescent proteins on either endothelial cells or granulocytes and macrophages, to explore the specific mechanism of ezetimibe and its role in reducing atherosclerosis-related hypercholesteremia. Read More

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November 2018
1 Read

Bidirectional effects of IL-10 regulatory B cells in Ldlr mice.

Atherosclerosis 2018 Nov 9;280:118-125. Epub 2018 Nov 9.

Division of BioTherapeutics, LACDR, Leiden University, Leiden, the Netherlands.

Background And Aims: Limiting the pro-inflammatory immune response is critical for the treatment of atherosclerosis. Regulatory B cells (Bregs) can modulate the immune response through interleukin-10 (IL-10). Current data regarding Bregs and atherosclerosis is scarce and conflicting. Read More

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November 2018
3 Reads

Safety and efficacy of mipomersen in patients with heterozygous familial hypercholesterolemia.

Atherosclerosis 2018 Nov 10;280:109-117. Epub 2018 Nov 10.

Sections of Cardiology and Cardiovascular Research, Baylor College of Medicine, Houston, TX, USA.

Background And Aims: Heterozygous familial hypercholesterolemia (HeFH) is a common genetic disorder characterized by elevated low-density lipoprotein cholesterol (LDL-C) and increased cardiovascular disease risk. Despite multiple LDL-C-lowering therapies, many HeFH patients do not reach LDL-C targets. Mipomersen, an antisense oligonucleotide against apolipoprotein B (apoB), might further lower LDL-C in HeFH patients. Read More

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November 2018
1 Read

Coronary heart disease risk factor levels in eastern and western Finland from 1980 to 2011 in the cardiovascular risk in Young Finns study.

Atherosclerosis 2018 Nov 15;280:92-98. Epub 2018 Nov 15.

Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.

Background And Aims: In the 1960s and 1970s, Finland, mortality due to coronary heart disease (CHD) was over 30% higher among Finns residing in the east of the country compared with those residing in the west. Today, CHD mortality remains 20% higher among eastern Finns. The higher incidence of CHD mortality among eastern Finns has largely been explained by higher risk factor levels. Read More

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November 2018
1 Read

New approach for detection of LDL-hypercholesterolemia in the pediatric population: The Fr1dolin-Trial in Lower Saxony, Germany.

Atherosclerosis 2018 Nov 17;280:85-91. Epub 2018 Nov 17.

Diabetes Center for Children and Adolescents, Children's Hospital AUF DER BULT, Hannover, Germany.

Background And Aims: Lipid disorders are often detected very late, particularly in affected young children. We evaluated the feasibility of a screening for LDL-hypercholesterolemia (highLDL) among toddlers and preschoolers.

Methods: Population-based screening has been offered to all children (2-6 years) living in the State of Lower Saxony, Germany, with capillary blood sampling for detection of elevated LDL-cholesterol (LDL-C ≥ 135 mg/dL). Read More

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November 2018
2 Reads

Comments on "Optimising treatment of hyperlipidaemia: Quantitative evaluation of UK, USA and European guidelines taking account of both LDL cholesterol levels and cardiovascular disease risk".

Authors:
Syed Raza Shah

Atherosclerosis 2018 Nov 13. Epub 2018 Nov 13.

North Florida Regional Medical Center, University of Central Florida (Gainesville), 6500 West Newberry Road, Gainesville, FL, 32605, USA. Electronic address:

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November 2018

Total body proteoglycan 4 (Prg4) deficiency increases atherosclerosis susceptibility in apolipoprotein E knockout and low-density lipoprotein receptor knockout mice.

Atherosclerosis 2018 Nov 30;278:315-316. Epub 2018 Jun 30.

Leiden Academic Centre for Drug Research, Leiden, The Netherlands.

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November 2018
1 Read

Reference values for cardiometabolic risk scores in children and adolescents: Suggesting a common standard.

Atherosclerosis 2018 Nov 6;278:299-306. Epub 2018 Oct 6.

Western Norway University of Applied Sciences, Department of Sport, Food and Natural Sciences, PO BOX 133, N-6856, Sogndal, Norway.

Background And Aims: International reference values for cardiometabolic risk variables, to allow for standardization of continuous risk scores in children, are not currently available. The aim of this study was to provide international age- and gender-specific reference values for cardiometabolic risk factors in children and adolescents.

Methods: Cohorts of children sampled from different parts of Europe (North, South, Mid and Eastern) and from the United States were pooled. Read More

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November 2018
6 Reads

Apabetalone downregulates factors and pathways associated with vascular calcification.

Atherosclerosis 2018 Nov 14;280:75-84. Epub 2018 Nov 14.

Resverlogix Corp., Calgary, Canada. Electronic address:

Background And Aims: Apabetalone is an inhibitor of bromodomain and extraterminal (BET) proteins. In clinical trials, apabetalone reduced the incidence of major adverse cardiac events (MACE) in patients with cardiovascular disease and reduced circulating factors that promote vascular calcification (VC). Because VC contributes to MACE, effects of apabetalone on pro-calcific processes were examined. Read More

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November 2018
5 Reads
3.994 Impact Factor

Severe atherosclerosis in the natural mummy of Girolamo Macchi (1648-1734), "major writer" of Santa Maria della Scala Hospital in Siena (Italy).

Atherosclerosis 2018 Nov 14;280:66-74. Epub 2018 Nov 14.

Division of Paleopathology, Department of Translational Research and of New Technologies in Medicine and Surgery, University of Pisa, Italy.

Background And Aims: A small crypt in the Santissima Annunziata Church of Santa Maria della Scala Hospital in Siena (Italy) contained three well-preserved mummies, two of which, dated back to the 15th-16th century, were identified as Salimbene Capacci (1433-1497), Rector of the Hospital, and his wife, Margherita Sozzini (?-1511). The third mummy, dressed in clothes of the 17th century, was not initially identified.

Methods: Accurate bibliographical, taphonomic and anthropological studies allowed the identification of the mummy of Girolamo Macchi, who lived between 1648 and 1734 and worked as "major writer", an accountant, for the Hospital. Read More

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November 2018
1 Read

Bridging the treatment gap in patients at 'extreme' cardiovascular risk: Evidence from a lipid clinic.

Atherosclerosis 2018 Nov 14. Epub 2018 Nov 14.

Department of Internal Medicine, Faculty of Medicine, University of Ioannina, Ioannina, Greece. Electronic address:

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November 2018
1 Read

Reply to: "Comment on "Mean platelet volume and long-term cardiovascular outcomes in patients with stable coronary artery disease" ".

Atherosclerosis 2018 Nov 14. Epub 2018 Nov 14.

Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.

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November 2018

Greater progression of coronary artery calcification is associated with clinically relevant cognitive impairment in type 1 diabetes.

Atherosclerosis 2018 Nov 8;280:58-65. Epub 2018 Nov 8.

Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

Background And Aims: We assessed the predictive role of coronary artery calcification (CAC) in clinically relevant cognitive impairment in 148 middle-aged individuals with childhood-onset type 1 diabetes (T1D) from the Pittsburgh Epidemiology of Diabetes Complications (EDC) Study.

Methods: Baseline CAC was measured in 1996-98 and repeated 4-8 years later. Per extensive neuropsychological testing in 2010-15, 28% (41/148) of participants met the study definition of clinically relevant cognitive impairment (two or more of 7 select test scores ≥1. Read More

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November 2018
3 Reads

NUtraceutical TReatment for hYpercholesterolemia in HIV-infected patients: The NU-TRY(HIV) randomized cross-over trial.

Atherosclerosis 2018 Nov 14;280:51-57. Epub 2018 Nov 14.

Unit of Infectious Diseases, Department of Medicine, University of Perugia, Perugia, 06129, Italy.

Background And Aims: Despite hypercholesterolemia has been recognized to increase cardiovascular risk in human immunodeficiency virus (HIV)-infected patients, cholesterol-lowering therapy is underused in this population, due to fear of drug-drug interactions with antiretroviral therapy (ART). We investigated the effects of a nutraceutical combination (NC) on lipid profile, proprotein convertase subtilisin/kexin type 9 (PCSK9), subclinical inflammation and arterial stiffness in ART-treated HIV-infected patients.

Methods: This was a prospective randomized open-label trial with a cross-over design including 30 stable HIV-infected patients on ART with low-density lipoprotein cholesterol (LDL-C) >115 mg/dL, not taking lipid-lowering treatment. Read More

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November 2018
4 Reads

Serum gamma-glutamyl transferase is associated with silent brain infarcts in a healthy population.

Atherosclerosis 2018 Nov 13;280:45-50. Epub 2018 Nov 13.

Department of Family medicine, Seoul National University College of Medicine and Seoul National University Hospital, Seoul, South Korea.

Background And Aims: Although there is substantial evidence that serum gamma-glutamyl transferase (GGT) is associated with cerebrovascular diseases, its role in silent brain infarcts (SBIs) has not been addressed. In this study, we evaluated the relationship between serum GGT and the presence of SBI in a neurologically healthy population.

Methods: We evaluated a consecutive series of healthy volunteers recruited between January 2006 and December 2013. Read More

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November 2018

Mechanisms involved in proton pump inhibitors-induced increases in ischemic events.

Atherosclerosis 2018 Nov 14. Epub 2018 Nov 14.

Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av. Bandeirantes, 3900, 14049-900, Ribeirao Preto, SP, Brazil.

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November 2018
3 Reads

ApoB in clinical care: Pro and Con.

Atherosclerosis 2018 Nov 10. Epub 2018 Nov 10.

Departments of Epidemiology and Internal Medicine, Division of Cardiology, University of Iowa, 145 N Riverside Dr S455 CPHB, Iowa City, IA, 52242, United States.

Whether apoB adds significantly to the assessment of the risk and therapy of the atherogenic dyslipoproteinemias has been vigorously contested over many years. That trapping of apoB lipoprotein particles within the arterial wall is fundamental to the initiation and maturation of atherosclerotic lesions within the arterial wall is now widely accepted. At the same time, the concept that primary prevention should be based on the risk of a cardiovascular event, a measure that integrates the effects of age, sex, blood pressure, lipids and other factors, has also become widely accepted. Read More

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November 2018
3 Reads
3.994 Impact Factor

Cholesterol and inflammatory risk: Insights from secondary and primary prevention.

Authors:
Jane K Stock

Atherosclerosis 2018 Oct 17. Epub 2018 Oct 17.

European Atherosclerosis Society, World Trade Center Göteborg, Mässans Gata 18, SE-412 51, Göteborg, Sweden. Electronic address:

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October 2018

Coronary heart disease mortality in severe vs. non-severe familial hypercholesterolaemia in the Simon Broome Register.

Atherosclerosis 2018 Nov 12. Epub 2018 Nov 12.

Wolfson College, University of Oxford, Oxford, UK.

Background And Aims: The International Atherosclerosis Society (IAS) has proposed that patients with "severe" FH (SFH) would warrant early and more aggressive cholesterol-lowering treatment such as with PCSK9 inhibitors. SFH is diagnosed if LDL-cholesterol (LDLC) > 10 mmol/L, or LDLC >8.0 mmol/L plus one high-risk feature, or LDLC >5 mmol/L plus two high-risk features. Read More

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November 2018
5 Reads

Performance of gender- and age-specific cut-points versus NCEP pediatric cutpoints in dyslipidemia screening among Chinese children.

Atherosclerosis 2018 Nov 10;280:37-44. Epub 2018 Nov 10.

Department of Epidemiology, Capital Institute of Pediatrics, Beijing, 100020, China; Graduate School of Peking Union Medical College, Peking Union Medical College, Beijing, 100730, China. Electronic address:

Background And Aims: Considerable attention is given nowadays to the presence of cardiovascular diseases risk factors in children. The current blood lipid classification system for Chinese children was based on the United States National Cholesterol Education Program (NCEP) cutpoints, which did not take the age, gender and race differences into consideration. This study aimed to develop gender- and age-specific lipid cutpoints for dyslipidemia screening in Chinese children and compare the ability of new cutpoints and NCEP pediatric cutpoints to predict obesity and unfavorable blood pressure (BP) levels. Read More

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November 2018
4 Reads

MicroRNA-142-3p improves vascular relaxation in uremia.

Atherosclerosis 2018 Nov 10;280:28-36. Epub 2018 Nov 10.

Department of Internal Medicine, Clinical Division of Nephrology, Medical University of Graz, Graz, Austria.

Background And Aims: Chronic kidney disease (CKD) is strongly associated with a high burden of cardiovascular morbidity and mortality. Therefore, we aimed to characterize the putative role of microRNAs (miR)s in uremic vascular remodelling and endothelial dysfunction.

Methods: We investigated the expression pattern of miRs in two independent end-stage renal disease (ESRD) cohorts and in the animal model of uremic DBA/2 mice via quantitative RT-PCR. Read More

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November 2018
4 Reads

Life course trajectories of cardiovascular risk: Impact on atherosclerotic and metabolic indicators.

Atherosclerosis 2018 Nov 8;280:21-27. Epub 2018 Nov 8.

Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.

Background And Aims: In this analysis, we estimated population-level trajectory groups of life course cardiovascular risk to explore their impact on mid-life atherosclerotic and metabolic outcomes.

Methods: This prospective study followed n = 1269 Bogalusa Heart participants, each with at least 4 study visits from childhood in 1973 through adulthood in 2016. We used discrete mixture modeling to determine trajectories of cardiovascular risk percentiles from childhood to adulthood. Read More

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November 2018
5 Reads

Association between proprotein convertase subtilisin/kexin 9 (PCSK9) and lipoprotein subclasses in children with type 1 diabetes mellitus: Effects of glycemic control.

Atherosclerosis 2018 Nov 9;280:14-20. Epub 2018 Nov 9.

Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.

Background And Aims: Dyslipidemia in type 1 diabetes mellitus (T1DM) is characterised by altered distributions of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses. Recent studies suggested that proprotein convertase subtilisin/kexin 9 (PCSK9) may contribute to the development of dyslipidemia in T1DM. In this cross-sectional study, we investigated the association between PCSK9 and lipoprotein subclasses in young T1DM patients, with respect to glycemic control. Read More

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November 2018
3 Reads

The combined utility of myeloperoxidase (MPO) and paraoxonase 1 (PON1) as two important HDL-associated enzymes in coronary artery disease: Which has a stronger predictive role?

Atherosclerosis 2018 Nov 8;280:7-13. Epub 2018 Nov 8.

Molecular and Cell Biology Research Center, Mazandaran University of Medical Sciences, Sari, Iran; Immunogenetics Research Center, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address:

Background And Aims: Serum paraoxonase 1 (PON1) and myeloperoxidase (MPO) are HDL-associated enzymes that contribute significantly to the formation of dysfunctional HDL. The present study thus seeks to comparatively analyze the predictive role of PON1, MPO and the MPO/PON1 ratio and to also evaluate which one has a stronger predictive role in their combined utility as an MPO/PON1 ratio in coronary artery disease (CAD).

Methods: PON1 activity and MPO concentrations were determined in patients with established CAD and those without significant CAD. Read More

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November 2018

Incidence of cardiovascular disease in familial combined hyperlipidemia: A 15-year follow-up study.

Atherosclerosis 2018 Nov 8;280:1-6. Epub 2018 Nov 8.

Department of Internal Medicine, Division of Endocrinology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, P. Debyelaan 25, 6229 HX, Maastricht, the Netherlands. Electronic address:

Background And Aims: Familial combined hyperlipidemia (FCHL) is a complex dyslipidemia associated with premature cardiovascular disease (CVD). The present study was conducted to 1) determine the incidence of CVD in FCHL in this era of protocolled, primary prevention; and 2) examine whether cardiovascular risk estimation based on the Systemic Coronary Risk Estimation (SCORE) chart, as proposed in the 2016 ESC/EAS guidelines for the management of dyslipidemia, is justified in FCHL.

Methods: FCHL patients, their normolipidemic (NL) relatives and spouses originally included in our baseline cohort in 1998-2005 (n = 596) were invited for a follow-up visit to determine the incidence of CVD, defined as (non-)fatal coronary artery disease, ischemic stroke and peripheral artery disease requiring invasive treatment. Read More

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November 2018
1 Read

Association of elevated circulating fibroblast growth factor 21 levels with prevalent and incident metabolic syndrome: The Multi-Ethnic Study of Atherosclerosis.

Atherosclerosis 2018 Oct 17. Epub 2018 Oct 17.

Lipid Research Group, School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia.

Background And Aims: Fibroblast growth factor 21 (FGF21) plays an important role in glucose and lipid metabolism. We have investigated the relationship of plasma FGF21 levels with both prevalent and incident metabolic syndrome (MetS) in participants from the Multi-Ethnic Study of Atherosclerosis (MESA).

Methods: 5783 participants from four major ethnic groups (non-Hispanic white, African American, Hispanic American, and Chinese American) were included in the cross-sectional analysis. Read More

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October 2018
3 Reads

Apoliporotein L3 interferes with endothelial tube formation via regulation of ERK1/2, FAK and Akt signaling pathway.

Atherosclerosis 2018 Dec 19;279:73-87. Epub 2018 Oct 19.

Laboratory of Molecular Biology of Inflammation, IBMM, Faculty of Sciences, Université Libre de Bruxelles, Gosselies, Belgium. Electronic address:

Background And Aims: Endothelial cells are main actors in vascular homeostasis as they regulate vascular pressure and permeability as well as hemostasis and inflammation. Disturbed stimuli delivered to and by endothelial cells correlate with the so-called endothelial dysfunction and disrupt this homeostasis. As constituents of the inner layer of blood vessels, endothelial cells are also involved in angiogenesis. Read More

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December 2018
1 Read

Spectrum of mutations of familial hypercholesterolemia in the 22 Arab countries.

Atherosclerosis 2018 Dec 19;279:62-72. Epub 2018 Oct 19.

College of Health Sciences, Biomedical Program, Qatar University, Doha, Qatar. Electronic address:

Background And Aims: Familial hypercholesterolemia (FH) is an inherited genetic disorder of lipid metabolism characterized by a high serum LDL-cholesterol profile and xanthoma formation, and FH increases the risk of premature atherosclerosis and cardiovascular disease (CVD). Mutations in the low-density lipoprotein (LDLR), apolipoprotein B (APOB), proprotein convertase subtilisin/kexin 9 (PCSK9), and LDLRAP1 genes have been associated with FH. Although FH is a major risk for CVD, the disease prevalence and its underlying molecular basis in the 22 Arab countries are still understudied. Read More

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December 2018
9 Reads

Effect of low carbohydrate high fat diet on LDL cholesterol and gene expression in normal-weight, young adults: A randomized controlled study.

Atherosclerosis 2018 Dec 17;279:52-61. Epub 2018 Oct 17.

Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, PB 1046, Blindern, 0317, Oslo, Norway; Norwegian National Advisory Unit on Familial Hypercholesterolemia, Oslo University Hospital, Rikshospitalet, Norway.

Background And Aims: The effects of a low carbohydrate/high fat (LCHF) diet on health are debated. This study aims to explore the effects of a diet with less than 20 g carbohydrates per day (LCHF) on plasma low density lipoprotein cholesterol (LDL-C) in young and healthy adults. The secondary aim is the assessment of lipid profile and peripheral blood mononuclear cells (PBMC) gene expression. Read More

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December 2018
10 Reads

Early onset ACS: An age based clinico-epidemiologic and angiographic comparison.

Atherosclerosis 2018 Dec 19;279:45-51. Epub 2018 Oct 19.

Department of Cardiology, Hero DMC Heart Institute, Ludhiana, India.

Background And Aims: Acute coronary syndrome (ACS) in the very young is a rare entity, with limited data. We aimed to study patterns and profile of ACS in patients aged 20-30 years in comparison with those above 30 years.

Methods: In this retrospective record-based study, the demographic and clinical profile of all patients with ACS in the last 12 years (n = 35259) was analysed: group I (20-30 years) and group II (above 30 years). Read More

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December 2018
9 Reads

Development and validation of modified risk prediction models for cardiovascular disease and its subtypes: The Hisayama Study.

Atherosclerosis 2018 Dec 17;279:38-44. Epub 2018 Oct 17.

Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka City, Fukuoka, 812-8582, Japan; Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka City, Fukuoka, 812-8582, Japan. Electronic address:

Background And Aims: Predicting cardiovascular events is of practical benefit for disease prevention. The aim of this study was to develop and evaluate an updated risk prediction model for cardiovascular diseases and its subtypes.

Methods: A total of 2462 community residents aged 40-84 years were followed up for 24 years. Read More

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December 2018
2 Reads

Time for risk assessment without borders.

Atherosclerosis 2018 Dec 21;279:93-94. Epub 2018 Oct 21.

Department of Medicine, Walter Reed National Military Medical Center, Bethesda, MD, USA.

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December 2018
2 Reads

A dose-response association between serum ferritin and metabolic syndrome?

Atherosclerosis 2018 Dec 21;279:130-131. Epub 2018 Oct 21.

School of Public Health, The First Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China. Electronic address:

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December 2018
4 Reads

Comment on "Mean platelet volume and long-term cardiovascular outcomes in patients with stable coronary artery disease".

Authors:
Erkan Coban

Atherosclerosis 2018 Oct 19. Epub 2018 Oct 19.

Akdeniz University Faculty of Medicine, Department of Internal Medicine, Antalya, Turkey. Electronic address:

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October 2018

T2 magnetic resonance mapping: The key to find the 'Brahmastra' against atherosclerosis?

Atherosclerosis 2018 Dec 19;279:95-96. Epub 2018 Oct 19.

Cardiovascular Biology and Biomechanics Laboratory, Cardiovascular Division, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address:

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December 2018
1 Read

Single and combined effects of peripheral artery disease and of type 2 diabetes mellitus on the risk of cardiovascular events: A prospective cohort study.

Atherosclerosis 2018 Dec 6;279:32-37. Epub 2018 Oct 6.

Division of Angiology, Swiss Cardiovascular Center, University Hospital Berne, Berne, Switzerland.

Background And Aims: The individual and combined effects of type 2 diabetes (T2DM) and peripheral artery disease (PAD) on future cardiovascular events are unknown and are addressed in the present investigation.

Methods: Cardiovascular events were prospectively recorded in 1049 subjects, encompassing 4 groups: 558 with neither PAD nor diabetes, 153 with T2DM but without PAD, 192 with PAD but without T2DM and 146 with the combination of PAD and T2DM.

Results: Over a mean follow-up period of 7. Read More

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December 2018
5 Reads

Toll-like receptor 4 contributes to a myofibroblast phenotype in cardiac fibroblasts and is associated with autophagy after myocardial infarction in a mouse model.

Atherosclerosis 2018 Dec 19;279:23-31. Epub 2018 Oct 19.

The Department of Pharmacology of Materia Medica (the State Key Laboratory of Functions and Applications of Medicinal Plants, The High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province, The Key Laboratory of Optimal Utilizaiton of Natural Medicine Resources), School of Pharmaceutical Sciences, Guizhou Medical University, University Town, Guian New District, Guizhou, 550025, China. Electronic address:

Background And Aims: Cardiac fibrosis after myocardial infarction (MI) is involved in fibroblast transforming and differentiating into myofibroblast phenoconversion, however, the underlying mechanisms are poorly understood. Toll-like receptor 4 (TLR4)-mediated pathogen-associated molecular patterns are key factors that deteriorate cardiac remodelling after MI. Moreover, autophagy has dual roles in cell survival in myocardial tissues after MI. Read More

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December 2018
6 Reads

Plasma levels of the oxyphytosterol 7α-hydroxycampesterol are associated with cardiovascular events.

Atherosclerosis 2018 Dec 17;279:17-22. Epub 2018 Oct 17.

Institut für Klinische Chemie und Klinische Pharmakologie, Universitätsklinikum Bonn, Germany. Electronic address:

Background And Aims: There are safety issues regarding plant sterol ester-enriched functional food. Oxidized plant sterols, also called oxyphytosterols, are supposed to contribute to plant sterol atherogenicity. This study aimed to analyze associations of plasma oxyphytosterol levels with cardiovascular events. Read More

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December 2018
4 Reads